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| Product | Description | |
|---|---|---|
| Difelikefalin | Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: CR-845; FE-202845. CAS No. 1024828-77-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-17609. |  |
| Difelikefalin | Difelikefalin is a Kappa Opioid Receptor Agonist. The mechanism of action of difelikefalin is as an Opioid kappa Receptor Agonist. Alternative Names: CR845. CR-845. MR13A9. CAS No. 1024828-77-0. Product ID: API1024828770. Molecular formula: C36H53N7O6. Mole weight: 679.8. SMILES: CC(C)C[C@H](C(=O)N[C@H](CCCCN)C(=O)N1CCC(CC1)(C(=O)O)N)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@@H](CC3=CC=CC=C3)N. Appearance: Solid Powder. Category: Peptide APIs. |  |
| Difelikefalin | Difelikefalin is an analgesic opioid peptide acting as a peripherally specific, highly selective agonist of the κ-opioid receptor (KOR). It acts as an analgesic by activating KORs on peripheral nerve terminals and KORs expressed by certain immune system cells. It may be useful in the prophylaxis and treatment of pain and inflammation associated with a variety of diseases and conditions. It is under development by Cara Therapeutics as an intravenous agent for the treatment of postoperative pain. It lacks the central side effects due to its peripheral selectivity. It is also being investigated for the treatment of pruritus (itching). It has completed phase II clinical trials for postoperative pain and has demonstrated significant and "robust" clinical efficacy, along with being safe and well-tolerated. It is also in phase II clinical trials for uremic pruritus in hemodialysis patients. Uses: Difelikefalin may be useful in the prophylaxis and treatment of pain and inflammation associated with a variety of diseases and conditions. it is used as an intravenous agent for the treatment of postoperative pain. it is also being investigated for the treatment of pruritus (itching). Synonyms: N1-(D-Phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-amino-4-piperidinecarboxylic acid; CR 845; D-Phe-D-Phe-D-Leu-D-Lys-[gamma-(4-N-piperidinyl)amino carboxylic acid]; 1-(D-Phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-aminopiperidine-4-c |  |
| Difelikefalin | Difelikefalin. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1024828-77-0. Molecular formula: C36H53N7O6. Mole weight: 679.86. Catalog: APB1024828770. |  |
| Difelikefalin acetate | Difelikefalin is an analgesic opioid peptide acting as a peripherally specific, highly selective agonist of the κ-opioid receptor (KOR). Synonyms: CR845 acetate; CR-845 acetate. CAS No. 1024829-44-4. Molecular formula: C38H57N7O8. Mole weight: 739.90. | |
| Difelikefalin Acid Impurity | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: DPhe-DPhe-DLeu-DLys; fflk; Difelikefalin impurity 24; D-Phenylalanyl-D-phenylalanyl-D-leucyl-D-lysine; H-D-Phe-D-Phe-D-Leu-D-Lys-OH; D-Phe-D-Phe-D-Leu-D-Lys. Grade: ≥95%. CAS No. 3029769-41-0. Molecular formula: C30H43N5O5. Mole weight: 553.69. | |
| Difelikefalin dimer | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: DPhe-DPhe-DLeu-DLys-Pip-DPhe-DPhe-DLeu-DLys-Pip; fflk-Pip-fflk-Pip; 1-((1-(D-Phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-aminopiperidine-4-carbonyl)-D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-aminopiperidine-4-carboxylic acid; D-Phe-D-Phe-D-Leu-D-Lys-4-amino-4-piperidinecarbonyl-D-Phe-D-Phe-D-Leu-D-Lys-4-amino-4-piperidinecarboxylic acid; Dimer Difelikefalin. Grade: ≥95%. Molecular formula: C72H104N14O11. Mole weight: 1341.68. | |
| Difelikefalin Enantiomer | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: Phe-Phe-Leu-Lys-4-Piperidinecarboxylic acid; Difelikefalin impurity; N1-(L-Phenylalanyl-L-phenylalanyl-L-leucyl-L-lysyl)-4-amino-4-piperidinecarboxylic acid; L-Phe-L-Phe-L-Leu-L-Lys-[gamma-(4-N-piperidinyl)amino carboxylic acid]; 1-(L-phenylalanyl-L-phenylalanyl-L-leucyl-L-lysyl)-4-aminopiperidine-4-carboxylic acid; Difelikefalin Impurity 14; Phe-Phe-Leu-Lys-4-amino-4-piperidinecarboxylic acid. Grade: ≥95%. CAS No. 2742623-84-1. Molecular formula: C36H53N7O6. Mole weight: 679.85. | |
| difelikefalin Impurity 5 | difelikefalin Impurity 5. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-amino-1-((R)-2-((R)-2-((R)-2-((R)-2-amino-3-phenylpropanamido)-3-phenylpropanamido)-4-methylpentanamido)-6-(methylamino)hexanoyl)piperidine-4-carboxylic acid. CAS No. 1024828-78-1. Molecular formula: C37H55N7O6. Mole weight: 693.88. Catalog: APB1024828781. | |
| difelikefalin Impurity 8 | difelikefalin Impurity 8. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-amino-1-((R)-2-((R)-2-((R)-2-((R)-2-amino-3-phenylpropanamido)-3-phenylpropanamido)-4-methylpentanamido)-6-(isopropylamino)hexanoyl)piperidine-4-carboxylic acid. CAS No. 1024828-90-7. Molecular formula: C39H59N7O6. Mole weight: 721.93. Catalog: APB1024828907. | |
| [D-Ile]3-Difelikefalin | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: DPhe-DPhe-DIle-DLys-Pip; D-Phe-D-Phe-D-Ile-D-Lys-Pip; ffik-Pip; 1-(D-Phenylalanyl-D-phenylalanyl-D-isoleucyl-D-lysyl)-4-aminopiperidine-4-carboxylic acid; D-Ile3-Difelikefalin; [D-Ile]3-Difelikefalin; [D-Ile3]-Difelikefalin; D-Ile-Difelikefalin; N1-(D-Phenylalanyl-D-phenylalanyl-D-isoleucyl-D-lysyl)-4-amino-4-piperidinecarboxylic acid; D-Phe-D-Phe-D-Ile-D-Lys-4-amino-4-piperidinecarboxylic acid. Grade: ≥95%. Molecular formula: C36H53N7O6. Mole weight: 679.85. | |
| [D-Lys(Ac)]4-Difelikefalin | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: DPhe-DPhe-DLeu-DLys(Ac)-Pip; 1-(N2-D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-acetyl-D-lysyl)-4-aminopiperidine-4-carboxylic acid; N1-(D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-acetyl-D-lysyl)-4-amino-4-piperidinecarboxylic acid; D-Phe-D-Phe-D-Leu-D-Lys(Ac)-4-amino-4-piperidinecarboxylic acid; ffl-DLys(Ac)-Pip; Difelikefalin acetate impurity 15; Lys4(Ac)-Difelikefalin; D-Lys4(Ac)-Difelikefalin; Lys(Ac)-Difelikefalin; Lys(Ac)4-Difelikefalin; [Lys(Ac)]4-Difelikefalin. Grade: ≥95%. Molecular formula: C38H55N7O7. Mole weight: 721.89. | |
| [D-Lys(EA)]4-Difelikefalin | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: DPhe-DPhe-DLeu-DLys(EA)-4-Piperidinecarboxylic acid; 4-Amino-1-((R)-2-((R)-2-((R)-2-((R)-2-amino-3-phenylpropanamido)-3-phenylpropanamido)-4-methylpentanamido)-6-((2-aminoethyl)amino)hexanoyl)piperidine-4-carboxylic acid; Difelikefalin impurity 10; 1-(N2-D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-(2-aminoethyl)-D-lysyl)-4-aminopiperidine-4-carboxylic acid; D-Phe-D-Phe-D-Leu-D-Lys(EA)-4-amino-4-piperidinecarboxylic acid; ffl-DLys(EA)-Pip; D-Lys4(EA)-Difelikefalin; D-Lys(EA)4-Difelikefalin. Grade: ≥95%. CAS No. 2219351-44-5. Molecular formula: C38H58N8O6. Mole weight: 722.92. | |
| [D-Lys(Ipr)]4-Difelikefalin | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: DPhe-DPhe-DLeu-DLys(Ipr)-4-Piperidinecarboxylic acid; Difelikefalin impurity 8; 1-[D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-(1-methylethyl)-D-lysyl]-4-amino-4-piperidinecarboxylic acid; 1-(N2-D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-isopropyl-D-lysyl)-4-aminopiperidine-4-carboxylic acid; D-Phe-D-Phe-D-Leu-D-Lys(Ipr)-4-amino-4-piperidinecarboxylic acid; ffl-DLys(Ipr)-Pip; D-Lys4(Ipr)-Difelikefalin; D-Lys(Ipr)4-Difelikefalin; 4-Amino-1-((R)-2-((R)-2-((R)-2-((R)-2-amino-3-phenylpropanamido)-3-phenylpropanamido)-4-methylpentanamido)-6-(isopropylamino)hexanoyl)piperidine-4-carboxylic acid. Grade: ≥95%. CAS No. 1024828-90-7. Molecular formula: C39H59N7O6. Mole weight: 721.93. | |
| [D-Lys(Me)]4-Difelikefalin | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: DPhe-DPhe-DLeu-DLys(Me)-4-Piperidinecarboxylic acid; Difelikefalin impurity 5; 1-(N2-D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-methyl-D-lysyl)-4-aminopiperidine-4-carboxylic acid; N1-(D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-methyl-D-lysyl)-4-amino-4-piperidinecarboxylic acid; D-Phe-D-Phe-D-Leu-D-Lys(Me)-4-amino-4-piperidinecarboxylic acid; ffl-DLys(Me)-Pip; D-Lys4(Me)-Difelikefalin; D-Lys(Me)4-Difelikefalin. Grade: ≥95%. CAS No. 1024828-78-1. Molecular formula: C37H55N7O6. Mole weight: 693.88. | |
| [D-Lys(Propylamine)]4-Difelikefalin | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: DPhe-DPhe-DLeu-DLys(Propylamine)-4-Piperidinecarboxylic acid; 4-Amino-1-((R)-2-((R)-2-((R)-2-((R)-2-amino-3-phenylpropanamido)-3-phenylpropanamido)-4-methylpentanamido)-6-((3-aminopropyl)amino)hexanoyl)piperidine-4-carboxylic acid; Difelikefalin impurity 11; D-Phe-D-Phe-D-Leu-D-Lys(Propylamine)-4-amino-4-piperidinecarboxylic acid; ffl-DLys(Propylamine)-Pip; D-Lys4(Propylamine)-Difelikefalin; D-Lys(Propylamine)4-Difelikefalin; 1-(N2-D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-(3-aminopropyl)-D-lysyl)-4-aminopiperidine-4-carboxylic acid. Grade: ≥95%. CAS No. 2219351-45-6. Molecular formula: C39H60N8O6. Mole weight: 736.94. | |
| [D-Lys(tBu)]4-Difelikefalin | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: DPhe-DPhe-DLeu-DLys(tBu)-4-Piperidinecarboxylic acid; Difelikefalin impurity 16; 1-(N2-D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-(tert-butyl)-D-lysyl)-4-aminopiperidine-4-carboxylic acid; N1-(D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-(tert-butyl)-D-lysyl)-4-amino-4-piperidinecarboxylic acid; D-Phe-D-Phe-D-Leu-D-Lys(tBu)-4-amino-4-piperidinecarboxylic acid; ffl-DLys(tBu)-Pip; D-Lys4(tBu)-Difelikefalin; D-Lys(tBu)4-Difelikefalin. Grade: ≥95%. Molecular formula: C40H61N7O6. Mole weight: 735.96. | |
| [D-Phe((βR)-Me)]1-Difelikefalin | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: beta-RMe-DPhe-DPhe-DLeu-DLys-4-Piperidinecarboxylic acid; 4-Amino-1-((R)-6-amino-2-((R)-N-((2R,3R)-2-amino-3-phenylbutanoyl)-2-((R)-2-amino-3-phenylpropanamido)-4-methylpentanamido)hexanoyl)piperidine-4-carboxylic acid; 4-Amino-1-(((2R,3R)-2-amino-3-phenylbutanoyl)-D-phenylalanyl-D-leucyl-D-lysyl)piperidine-4-carboxylic acid; Difelikefalin impurity 9; [beta-RMe-D-Phe]1-Difelikefalin; [β-(R)-Me-D-Phe]1-Difelikefalin; [D-Phe(βR-Me)]1-Difelikefalin. Grade: ≥95%. CAS No. 2756592-19-3. Molecular formula: C37H55N7O6. Mole weight: 693.88. | |
| [D-Phe(EA)]1-Difelikefalin | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: Ethylamine-DPhe-DPhe-DLeu-DLys-4-Piperidinecarboxylic acid; 4-Amino-1-((2R,5R,8R,11R)-14-amino-2-(4-aminobutyl)-8,11-dibenzyl-5-isobutyl-4,7,10-trioxo-3,6,9,12-tetraazatetradecan-1-oyl)piperidine-4-carboxylic acid; 4-Amino-1-((2-aminoethyl)-D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)piperidine-4-carboxylic acid; Difelikefalin impurity 12; D-Phe(EA)-D-Phe-D-Leu-D-Lys-4-amino-4-piperidinecarboxylic acid; f(EA)flk-Pip; D-Phe1(EA)-Difelikefalin; D-Phe(EA)1-Difelikefalin. Grade: ≥95%. CAS No. 2219351-61-6. Molecular formula: C38H58N8O6. Mole weight: 722.92. | |
| (1-(L-Isoleucyl)piperidine-4-carbonyl)-L-phenylalanine | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: Ile-Inp-Phe; Difelikefalin impurity 3; N-[[1-[(2S,3S)-2-Amino-3-methyl-1-oxopentyl]-4-piperidinyl]carbonyl]-D-phenylalanine; (S)-2-(1-((2S,3S)-2-Amino-3-methylpentanoyl)piperidine-4-carboxamido)-3-phenylpropanoic acid. Grade: ≥95%. Molecular formula: C21H31N3O4. Mole weight: 389.49. | |
| 1-(L-Leucyl-L-lysyl)-4-aminopiperidine-4-carboxylic acid | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: Leu-Lys-Pip; Difelikefalin impurity 19; LK-Pip; Leu-Lys-4-amino-4-piperidinecarboxylic acid; N1-(L-Leucyl-L-lysyl)-4-amino-4-piperidinecarboxylic acid. Grade: ≥95%. Molecular formula: C18H35N5O4. Mole weight: 385.51. | |
| (1-(L-Leucyl)piperidine-4-carbonyl)-D-phenylalanine | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: Leu-Inp-DPhe; Difelikefalin impurity 2; (R)-2-(1-((S)-2-Amino-4-methylpentanoyl)piperidine-4-carboxamido)-3-phenylpropanoic acid; N-[[1-[(2S)-2-Amino-4-methyl-1-oxopentyl]-4-piperidinyl]carbonyl]-D-phenylalanine. Grade: ≥95%. CAS No. 1173674-34-4. Molecular formula: C21H31N3O4. Mole weight: 389.49. | |
| 1-(L-Phenylalanyl-D-leucyl-D-lysyl)-4-aminopiperidine-4-carboxylic acid | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: Phe-DLeu-DLys-Pip; Difelikefalin impurity 20; Flk-Pip; N1-(L-Phenylalanyl-D-leucyl-D-lysyl)-4-amino-4-piperidinecarboxylic acid; L-Phe-D-Leu-D-Lys-4-amino-4-piperidinecarboxylic acid. Grade: ≥95%. Molecular formula: C27H44N6O5. Mole weight: 532.68. | |
| 1-(L-Phenylalanyl-L-phenylalanyl-L-leucyl-D-lysyl)-4-aminopiperidine-4-carboxylic acid | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: Phe-Phe-Leu-DLys-Pip; FFLk-Pip; Difelikefalin impurity 26; N1-(L-Phenylalanyl-L-phenylalanyl-L-leucyl-D-lysyl)-4-amino-4-piperidinecarboxylic acid; L-Phe-L-Phe-L-Leu-D-Lys-4-amino-4-piperidinecarboxylic acid. Grade: ≥95%. Molecular formula: C36H53N7O6. Mole weight: 679.85. | |
| (1-(L-Phenylalanyl)piperidine-4-carbonyl)-L-proline | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: Phe-Inp-Pro; (S)-1-(1-((S)-2-Amino-3-phenylpropanoyl)piperidine-4-carbonyl)pyrrolidine-2-carboxylic acid; Difelikefalin impurity 7; 1-[[1-[(2S)-2-Amino-1-oxo-3-phenylpropyl]-4-piperidinyl]carbonyl]-L-proline. Grade: ≥95%. CAS No. 956233-15-1. Molecular formula: C20H27N3O4. Mole weight: 373.45. | |
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