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| Product | Description | |
|---|---|---|
| dihydroorotate dehydrogenase (fumarate) | Binds FMN. The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. Molecular oxygen can replace fumarate in vitro. Other class 1 dihydroorotate dehydrogenases use either NAD+ (EC 1.3.1.14) or NADP+ (EC 1.3.1.15) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor. Group: Enzymes. Synonyms: DHOdehase (ambiguous); dihydroorotate dehydrogenase (ambiguous); dihydoorotic acid dehydrogenase (ambiguous); DHOD (ambiguous); DHODase (ambiguous); dihydroorotate oxidase, pyr4 (gene name). Enzyme Commission Number: EC 1.3.98.1. CAS No. 9029-3-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1417; dihydroorotate dehydrogenase (fumarate); EC 1.3.98.1; 9029-03-2; DHOdehase (ambiguous); dihydroorotate dehydrogenase (ambiguous); dihydoorotic acid dehydrogenase (ambiguous); DHOD (ambiguous); DHODase (ambiguous); dihydroorotate oxidase, pyr4 (gene name). Cat No: EXWM-1417. |  |
| Dihydroorotate Dehydrogenase Inhibitor, Brequinar (6-fluoro-2-(2-fluoro-1,1-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic Acid Sodium Salt, NSC 368390, DuP 785) | A quinolinecarboxylic acid derivative with immunosuppressive and anti-neoplastic properties. Inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50 = 12nM). Does not affect DHODH in non-mammalian species. Also reported to inhibit glycosylation of adhesion molecules. Potentiates the sensitivity of U1690 small cell lung cancer cells to TRAIL-induced apoptosis and synergistically enhances the anti-tumor effects of doxorubicin ( ~100uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 96201-88-6. Pack Sizes: 10mg. Molecular Formula: C??H??F?NNaO?, Primary Target: DHODH. US Biological Life Sciences. |  Worldwide |
| dihydroorotate dehydrogenase (NAD+) | Binds FMN, FAD and a [2Fe-2S] cluster. The enzyme consists of two subunits, an FMN binding catalytic subunit and a FAD and iron-sulfur binding electron transfer subunit. The reaction, which takes place in the cytosol, is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides. Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NADP+ (EC 1.3.1.15) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor. Group: Enzymes. Synonyms: orotate reductase (NADH); orotate reductase (NADH2); DHOdehase (ambiguous); DHOD (ambiguous); DHODase (ambiguous); dihydroorotate oxidase, pyrD (gene name). Enzyme Commission Number: EC 1.3.1.14. CAS No. 37255-26-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1288; dihydroorotate dehydrogenase (NAD+); EC 1.3.1.14; 37255-26-8; orotate reductase (NADH); orotate reductase (NADH2); DHOdehase (ambiguous); DHOD (ambiguous); DHODase (ambiguous); dihydroorotate oxidase, pyrD (gene name). Cat No: EXWM-1288. | |
| dihydroorotate dehydrogenase (NADP+) | Binds FMN and FAD. Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NAD+ (EC 1.3.1.14) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor. Group: Enzymes. Synonyms: orotate reductase; dihydro-orotic dehydrogenase; L-5,6-dihydro-orotate:NAD+ oxidoreductase; orotate reductase (NADPH). Enzyme Commission Number: EC 1.3.1.15. CAS No. 37255-27-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1289; dihydroorotate dehydrogenase (NADP+); EC 1.3.1.15; 37255-27-9; orotate reductase; dihydro-orotic dehydrogenase; L-5,6-dihydro-orotate:NAD+ oxidoreductase; orotate reductase (NADPH). Cat No: EXWM-1289. | |
| dihydroorotate dehydrogenase (quinone) | This Class 2 dihydroorotate dehydrogenase enzyme contains FMN. The enzyme is found in eukaryotes in the mitochondrial membrane, in cyanobacteria, and in some Gram-negative and Gram-positive bacteria associated with the cytoplasmic membrane. The reaction is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides. The best quinone electron acceptors for the enzyme from bovine liver are ubiquinone-6 and ubiquinone-7, although simple quinones, such as benzoquinone, can also act as acceptor at lower rates. Methyl-, ethyl-, tert-butyl and benzyl (S)-dihydroorotates are also substrates, but methyl esters of (S)-1-methyl and (S)-3-methyl and (S)-1,3-dimethyldihydroorotates are not. Class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1), NAD+ (EC 1.3.1.14) or NADP+ (EC 1.3.1.15) as electron acceptor. Group: Enzymes. Synonyms: dihydroorot. Enzyme Commission Number: EC 1.3.5.2. CAS No. 59088-23-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1386; dihydroorotate dehydrogenase (quinone); EC 1.3.5.2; 59088-23-2; dihydroorotate:ubiquinone oxidoreductase; (S)-dihydroorotate:(acceptor) oxidoreductase; (S)-dihydroorotate:acceptor oxidoreductase; DHOdehase (ambiguous); DHOD (ambiguous); DHODase (ambiguous); DHODH. Cat No: EXWM-1386. | |
| 2-Fluoro-4-picoline | 2-Fluoro-4-picoline has been used as a reactant for the preparation of 2-(3-alkoxy-1H-pyrazol-1-yl)azines as inhibitors of human dihydroorotate dehydrogenase (DHODH). Group: Biochemicals. Grades: Highly Purified. CAS No. 461-87-0. Pack Sizes: 1g, 5g. Molecular Formula: C6H6FN, Molecular Weight: 111.12. US Biological Life Sciences. | Worldwide |
| 3-Aminopyrazole-4-carboxamide Sulfate | 3-Aminopyrazole-4-carboxamide Sulfate is used in the synthesis of triazolopyrimidines as inhibitors of plasmodium falciparum dihydroorotate dehydrogenase. Group: Biochemicals. Grades: Highly Purified. CAS No. 329351-43-1. Pack Sizes: 100mg, 500mg. Molecular Formula: C4H6N4O (H2O4S). US Biological Life Sciences. | Worldwide |
| BAY-2402234 | BAY-2402234 is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies. BAY 2402234 is a selective low-nanomolar inhibitor of human DHODH enzymatic activity. In vitro, it potently inhibits proliferation of AML cell lines in the sub-nanomolar to low-nanomolar range. BAY 2402234 induces differentiation of AML cell lines also in a sub-nanomolar to low-nanomolar range, demonstrating the anticipated mode of action in cellular mechanistic assays. In vivo, BAY 2402234 exhibits strong in vivo anti-tumor efficacy in monotherapy in several subcutaneous and disseminated AML xenografts as well as AML patient-derived xenograft (PDX) models. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BAY-2402234; BAY 2402234; BAY2402234; Orludodstat; Orludodstatum. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2225819-06-5. Molecular formula: C21H18ClF5N4O4. Mole weight: 520.84. Purity: >98%. IUPACName: (S)-N-(2-chloro-6-fluorophenyl)-4-(4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-5-fluoro-2-((1,1,1-trifluoropropan-2-yl)oxy)benzamide. Canonical SMILES: FC1=C(NC(C2=CC(F)=C(N3N=C(CO)N(CC)C3=O)C=C2O[C@@H](C)C(F)(F)F)=O)C(Cl)=CC=C1. Product ID: ACM2225819065. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Brequinar | Brequinar is a synthetic quinolinecarboxylic acid analogue with antineoplastic properties. Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby blocking de novo pyrimidine biosynthesis. This agent may also enhance the in vivo antitumor effect of antineoplastic agents such as 5-FU. Check for active clinical trials or closed clinical trials using this agent. Synonyms: DUP785; NSC 368390; 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid; 6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid; 4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-; Biphenquinate. Grades: ≥98%. CAS No. 96187-53-0. Molecular formula: C23H15F2NO2. Mole weight: 375.37. |  |
| Brequinar sodium | Brequinar sodium is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = ~20 nM), which causes the blockade of de novo pyrimidine nucleotide biosynthesis. Uses: Antineoplastic agents. Synonyms: Dup785; Dup 785; Dup-785; Brequinar Sodium. 6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium; Dup 785. Grades: ≥99% by HPLC. CAS No. 96201-88-6. Molecular formula: C23H14F2NO2Na. Mole weight: 397.35. | |
| DSM265 | DSM265 is a long-duration inhibitor of P. falciparum dihydroorotate dehydrogenase ( Pf DHODH ) with an IC 50 of 8.9 nM. DSM265 can also inhibit the growth of Pf 3D7 parasites with an EC 50 of 4.3 nM [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1282041-94-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-100184. |  |
| DSM265 | DSM265 is a selective DHODH (dihydroorotate dehydrogenase) inhibitor used for prevention and treatment of malaria. DSM265 is highly selective toward DHODH of the malaria parasite Plasmodium. It is efficacious against both blood and liver stages of P. falciparum and active against drug-resistant parasite isolates. Treatment for malaria was in phase II clinical trials. Uses: Malaria. Synonyms: DSM265; DSM-265; DSM 265; UNII-0Q42P4YI6B; 0Q42P4YI6B; CHEMBL1956285; SCHEMBL14053411;2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-$l^{6}-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine. Grades: 98%. CAS No. 1282041-94-4. Molecular formula: C14H12F7N5S. Mole weight: 415.34. | |
| Farudodstat | Farudodstat is an orally active and potent inhibitor of DHODH (human dihydroorotate dehydrogenase). It inhibits the proliferation of MOLM-14 and KG-1 acute myeloid leukemia (AML) cells (IC50s = 0.582 and 0.382 μM, respectively), as well as induces apoptosis in the same cells when used at concentrations of 0.5 and 1 μM. Synonyms: 2-[(3,5-difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino]pyridine-3-carboxylic acid; ASLAN003; 2-[(3,5-Difluoro-3'-methoxy-4-biphenylyl)amino]nicotinic Acid; 3-Pyridinecarboxylic acid, 2-[(3,5-difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino]-; 2-((3,5-Difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)nicotinic acid; 2-[(3,5-difluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]-3-pyridinecarboxylic acid. Grades: ≥98%. CAS No. 1035688-66-4. Molecular formula: C19H14F2N2O3. Mole weight: 356.32. | |
| hDHODH-IN-1 | hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory effect [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1173715-42-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135658. | |
| hDHODH-IN-13 | hDHODH-IN-13 (compound w2) is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC 50 value of 173.4 nM. hDHODH-IN-13 can be used in the research of IBD [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3032611-13-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149642. | |
| hDHODH-IN-3 | hDHODH-IN-3 (compound 21d) is a human dihydroorotate dehydrogenase (HsDHODH) inhibitor, inhibits measles virus replication with a pMIC 50 value of 8.6 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1644156-80-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-135570. | |
| L-Dihydroorotic acid | L-Dihydroorotic acid is an important intermediate in the metabolism of orotic acid and a substrate of dihydroorotate dehydrogenase ( DHODH ). L-Dihydroorotic acid can reversibly hydrolyze to yield the acyclic L-ureidosuccinic acid by dihydrowhey enzyme [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 5988-19-2. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-W015495. | |
| Leflunomide | Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase (DHODH), and acts as a disease-modifying antirheumatic agent. Uses: Scientific research. Group: Natural products. Alternative Names: HWA486; RS-34821; SU101. CAS No. 75706-12-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0083. | |
| Leflunomide-d4 (5- methyl isoxazole-4- [4-trifluoro methyl carboxanilide] -d4) | An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Group: Biochemicals. Alternative Names: 5- methyl isoxazole-4- [4-trifluoro methyl carboxanilide] -d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Olorofim | Olorofim (F901318) selectively inhibits fungal dihydroorotate dehydrogenase (DHODH) , a key enzyme in the pyrimidine biosynthesis pathway. Olorofim (F901318). Olorofim exhibits excellent activity against A. fumigatus and other Aspergillus spp. [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: F901318. CAS No. 1928707-56-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104029. | |
| Orotic acid | Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 6-Carboxyuracil; Vitamin B13. CAS No. 65-86-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-N0157. | |
| Orotic acid | Orotic acid is a heterocyclic compound and an acid. It is manufactured in the body via a mitochondrial enzyme, dihydroorotate dehydrogenase, or a cytoplasmic enzyme of pyrimidine synthesis pathway. Synonyms: UK-20349; UK 20349; UK20349. Grades: >98%. CAS No. 65-86-1. Molecular formula: C5H4N2O4. Mole weight: 156.1. | |
| Orotic acid zinc | Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 6-Carboxyuracil zinc; Vitamin B13 zinc. CAS No. 68399-76-8. Pack Sizes: 100 mg; 500 mg. Product ID: HY-N0157A. | |
| PfDHODH-IN-1 | PfDHODH-IN-1 is an analogue of the active metabolite of Leflunomide. PfDHODH-IN-1 is a Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor. PfDHODH-IN-1 has antimalarial activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 183945-55-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135648. | |
| Polyporic acid | Polyporic acid is an intermediate in the biosynthesis of allantofuranone first isolated from a mycelial culture of the fungus species Hapalopilus nidulans. It inhibits the enzyme dihydroorotate dehydrogenase and has some antifungal and antibacterial activity. Synonyms: 3',6'-dihydroxy-[1,1':4',1''-terphenyl]-2',5'-dione; Orygameic acid; 2,5-Dihydroxy-3,6-diphenyl-p-benzoquinone; NSC 44175; 2,5-Cyclohexadiene-1,4-dione, 2,5-dihydroxy-3,6-diphenyl-. Grades: ≥95%. CAS No. 548-59-4. Molecular formula: C18H12O4. Mole weight: 292.29. | |
| PTC299 | PTC299 is an orally active inhibitor of VEGFA mRNA translation that selectively inhibits VEGF protein synthesis at the post-transcriptional level. PTC299 is also a potent inhibitor of dihydroorotate dehydrogenase (DHODH). PTC299 shows good oral bioavailability and lack of off-target kinase inhibition and myelosuppression. PTC299 can be useful for the research of hematologic malignancies [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1256565-36-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-124593. | |
| Tenovin-1 | Tenovin-1, a p53 activator, protects p53 from MDM2-mediated degradation. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also a dihydroorotate dehydrogenase (DHODH) inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 380315-80-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13423. | |
| Tenovin-6 | Tenovin-6, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC 50 s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 also inhibits dihydroorotate dehydrogenase (DHODH) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1011557-82-6. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15510. | |
| Tenovin-6 Hydrochloride | Tenovin-6 Hydrochloride, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 Hydrochloride inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC 50 s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 Hydrochloride also inhibits dihydroorotate dehydrogenase (DHODH) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1011301-29-3. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15510B. | |
| Vidofludimus | Vidofludimus is an orally active and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH. Phase 2. Synonyms: SC12267, SC 12267; SC-12267; 4SC-101; 4SC 101; 4SC101. Grades: 98%. CAS No. 717824-30-1. Molecular formula: C20H18FNO4. Mole weight: 355.36. | |
| Vidofludimus | Vidofludimus is an orally active inhibitor for dihydroorotate dehydrogenase (DHODH) and also is a novel modulator for farnesoid X receptor (FXR). Vidofludimus, as an immunomodulatory agent, can be used for the research of autoimmune disorders such as inflammatory bowel disease (IBD). Vidofludimus also can be used for the research of fatty liver by targeting FXR [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4sc-101; SC12267. CAS No. 717824-30-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14908. | |
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