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Dimethyl fumarate Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 624-49-7. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g. Product ID: HY-17363. MedChemExpress MCE
Dimethyl fumarate Dimethyl fumarate. Group: Biochemicals. Alternative Names: Fumaric acid dimethyl ester. Grades: Highly Purified. CAS No. 624-49-7. Pack Sizes: 50g, 100g, 250g, 500g, 1Kg. Molecular Formula: C6H8O4. US Biological Life Sciences. USBiological 7
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Dimethyl fumarate Dimethyl fumarate is a Nrf2 activator used to treat adults with relapsing forms of multiple sclerosis. Uses: Dermatologic agents; immunosuppressive agents; radiation-sensitizing agents. Synonyms: Tecfidera; Dimethylfumarate; Methyl fumarate. Grade: 99.88%. CAS No. 624-49-7. Molecular formula: C6H8O4. Mole weight: 144.12. BOC Sciences 7
Dimethyl Fumarate White crystals, 98%. CAS No. 624-49-7. Pack Sizes: 100g, 500g. Product ID: FR-1080. M.P. 103-104. Mole weight: 144.13. Frinton Laboratories Inc
Frinton Laboratories
Dimethyl Fumarate-[d2] Dimethyl Fumarate-[d2] is the labelled analogue of Dimethyl Fumarate. Dimethyl Fumarate is the methyl ester form of Fumaric Acid, and is a compound used in the treatment of the relapsing forms of multiple sclerosis and psoriasis. Synonyms: Dimethyl Fumarate D2; Fumaric-d2 Acid Dimethyl Ester; Dimethyl Fumarate-d2; (2E)-2-Butenedioic-2,3-d2 Acid Dimethyl Ester; (E)-2-Butenedioic-2,3-d2 Acid Dimethyl Ester; Dimethyl fumarate-2,3-d2. Grade: 97% by CP; 98% atom D. CAS No. 23057-98-9. Molecular formula: C6H6D2O4. Mole weight: 146.14. BOC Sciences 2
Dimethyl Fumarate-[d6] Dimethyl Fumarate-[d6] is the labelled analogue of Dimethyl fumarate. Dimethyl fumarate is a prescription medicine sold under the trade name Tecfidera for the treatment of relapsing forms of multiple sclerosis. Synonyms: Dimethyl Fumarate D6; Bis[(2H3)methyl] (2E)-2-butenedioate. Grade: 98% by HPLC; 98% atom D. CAS No. 66487-95-4. Molecular formula: C6H2D6O4. Mole weight: 150.16. BOC Sciences 2
2- ( ( (5- ( (Dimethylamino) methyl) furan-2-yl) methyl) thio) ethanamine Fumarate (2:1) 2- ( ( (5- ( (Dimethylamino) methyl) furan-2-yl) methyl) thio) ethanamine (E)-2-Butenedioate is an impurity of Ranitidine (R120000), a histamine H2-receptor antagonist which inhibits gastric acid secretion. Antiulcerative. Group: Biochemicals. Grades: Highly Purified. CAS No. 256948-32-0. Pack Sizes: 10mg, 50mg. Molecular Formula: C20H36N4O2S2 C4H4O4. US Biological Life Sciences. USBiological 9
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3-(4-Chlorobenzyl)-1-(dimethylamino)pentan-3-ol Fumarate Salt 3-(4-Chlorobenzyl)-1-(dimethylamino)pentan-3-ol Fumarate Salt is a useful synthetic intermediate. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C14H22ClNO; (C4H4O4), Molecular Weight: 255.781160699999. US Biological Life Sciences. USBiological 10
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Dimethylaminocarboxymethyl POC Tenofovir Fumarate One impurity of Tenofovir, which is an acyclic phosphonate nucleotide derivative, could be used in antiviral treatment as an everse transcriptase inhibitor. Grade: > 95%. Molecular formula: C18H29N6O9P. C4H4O4. Mole weight: 620.51. BOC Sciences 7
Dimethyl dihydroxyfumarate Dimethyl dihydroxyfumarate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: methyl (Z)-3,4-dihydroxy-4-methoxy-2-oxo-but-3-enoate;(E)-2,3-Dihydroxy-2-butenedioic acid dimethyl ester;Dimethyl dihydroxyfumarate;Methyl 3,4-dihydroxy-4-methoxy-2-oxobut-3-enoate;Dihydroxyfumaric acid dimethyl ester;Fumaric acid, dihydroxy-, dimethyl. Product Category: Heterocyclic Organic Compound. CAS No. 133-47-1. Molecular formula: C6H8O6. Mole weight: 176.12. Density: 1.434. Product ID: ACM133471. Alfa Chemistry — ISO 9001:2015 Certified. Alfa Chemistry. 5
Oxytocin Receptor Antagonist, MSC1630296 (OT-R Antagonist, 3- (4- (N- (4-chlorophenyl) -N- (2-oxo-2- (2- (2-oxoindolin-3-ylidene) hydrazinyl) ethyl) sulfamoyl) phenyl) -N- (3- (dimethylamino) propyl) propanamide, Fumarate Salt) A tertiary sulfonamide-based compound that acts as a high-affinity oxytocin (OT) receptor-selective antagonist (Ki = 650 and 670pM in 125I-OVTA-competitive binding assays using human and rat OT-R, respectively), while displaying 65-, 245-, and 23,000-fold reduced affinity, respectively, toward human vassopressin receptors V1a, V2, and V1b. Shown to effectively inhibit OT- (10nM) induced Ca2+ mobilization in hOT-R-expressing HEK293-EBNA cells (IC50 = 14nM) in vitro and OT-stimulated uterine contractions in rats (1.4 -10mg/kg p.o. or 30mg/kg p.o.) in vivo. Product is supplied as a fumarate salt for enhanced aqueous solubility (20 and 10mg/ml, respectively, in water and HBSS). Group: Biochemicals. Grades: Purified. Pack Sizes: 2mg. Molecular Formula: C??H??ClN?O?S.C?H?O?. US Biological Life Sciences. USBiological 4
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4-Chloro bupropion fumarate 4-Chloro bupropion fumarate. Group: Biochemicals. Alternative Names: 1-(3,4-Dichlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone (2E)-2-butenedioate. Grades: Highly Purified. CAS No. 1193779-36-0. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C17H21Cl2NO5. US Biological Life Sciences. USBiological 6
Worldwide
5-Chloro bupropion fumarate 5-Chloro bupropion fumarate. Group: Biochemicals. Alternative Names: 1-(3,5-Dichlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone (2E)-2-butenedioate. Grades: Highly Purified. CAS No. 1193779-50-8. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C17H21Cl2NO5. US Biological Life Sciences. USBiological 6
Worldwide
Atpenin A5 Antibiotic. Antifungal. Potent and specific mitochondrial complex II (succinate-ubiquinone oxidoreductase) inhibitor. Mitochondrial ATP-sensitive potassium (mK(ATP)) channel activator. Cardioprotective. Modulates mitochondrial ROS generation during cardioprotection.The IC50 value against bovine heart complex II is 3.6nM (which is ~300-fold lower than the IC50 value of carboxin (1.1uM)). It also inhibits fumarate reductase of Ascaris suum (IC50 = 12nM). Inhibition of E. coli succinate dehydrogenase is less potent (IC50 = 5uM). By co-crystallization studies of atpenin A5 and complex II, the binding site of atpenin A5 was found to be the quinone-binding site of complex II. Additionally, atpenin A5 has been shown to have a protective action against ischemia-reperfusion via the activation of mitochondrial KATP channels. Group: Biochemicals. Alternative Names: 3-[(2S,4S,5R)-5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone. Grades: Highly Purified. CAS No. 119509-24-9. Pack Sizes: 250ug, 1mg. Molecular Formula: C15H21Cl2NO5. US Biological Life Sciences. USBiological 3
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Bedaquiline fumarate Bedaquiline fumarate is an anti-tuberculosis drug which selectively inhibits the mycobacterial energy metabolism and found to be effective against all states of Mycobacterium tuberculosis. It possesses a unique mechanism of action that disrupts the activity of the mycobacterial adenosine triphosphate synthase. It has an excellent in vitro activity against Mycobacterium tuberculosis, including multidrug resistant M tuberculosis, however, its side effect profile limits its use against MDR-TB when no other effective regimen can be provided. Uses: Antitubercular agents. Synonyms: (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-ol fumarate. Grade: >98%. CAS No. 845533-86-0. Molecular formula: C36H35BrN2O6. Mole weight: 671.58. BOC Sciences 6
Desvenlafaxine fumarate An impurity of Venlafaxine. Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that is used as an antidepressant. According to different doses, it effects on serotonergic transmission, noradrenergic systems and dopaminergic neurotransmission. Venlafaxine is commonly used to treat depression, general anxiety disorder, social phobia, panic disorder, and vasomotor symptoms. Synonyms: O-Desmethylvenlafaxine fumarate; 4-(2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol fumarate. Grade: 95%. CAS No. 93414-04-1. Molecular formula: C20H29NO6. Mole weight: 379.45. BOC Sciences 7
dihydroorotate dehydrogenase (quinone) This Class 2 dihydroorotate dehydrogenase enzyme contains FMN. The enzyme is found in eukaryotes in the mitochondrial membrane, in cyanobacteria, and in some Gram-negative and Gram-positive bacteria associated with the cytoplasmic membrane. The reaction is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides. The best quinone electron acceptors for the enzyme from bovine liver are ubiquinone-6 and ubiquinone-7, although simple quinones, such as benzoquinone, can also act as acceptor at lower rates. Methyl-, ethyl-, tert-butyl and benzyl (S)-dihydroorotates are also substrates, but methyl esters of (S)-1-methyl and (S)-3-methyl and (S)-1,3-dimethyldihydroorotates are not. Class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1), NAD+ (EC 1.3.1.14) or NADP+ (EC 1.3.1.15) as electron acceptor. Group: Enzymes. Synonyms: dihydroorot. Enzyme Commission Number: EC 1.3.5.2. CAS No. 59088-23-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1386; dihydroorotate dehydrogenase (quinone); EC 1.3.5.2; 59088-23-2; dihydroorotate:ubiquinone oxidoreductase; (S)-dihydroorotate:(acceptor) oxidoreductase; (S)-dihydroorotate:acceptor oxidoreductase; DHOdehase (ambiguous); DHOD (ambiguous); DHODase (ambiguous); DHODH. Cat No: EXWM-1386. Creative Enzymes
Dimethyaminocarboxymethyl POC Tenofovir Dimethyaminocarboxymethyl POC Tenofovir is an impurity of Tenofovir Disoproxil Fumarate, which is a potent reverse transcriptase inhibitor used to treat chronic hepatitis B and to prevent and treat HIV/AIDS. Synonyms: (1-Methylethyl) (5RS)-5-{[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl}-10-methyl-5,9-dioxo-2,4,6,8-tetraoxa-10-aza-5-λ5-phosphaundecanoate; ((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)oxy)methyl dimethylcarbamate; [(Dimethylcarbamoyl)oxy]methyl[(isopropoxycarbonyl)oxy]methyl ({[(2R)-1-(6-amino-9H-purin-9-yl)-2-propanyl]oxy}methyl)phosphonate; Carbonic acid, [[[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl][[[(dimethylamino)carbonyl]oxy]methoxy]phosphinyl]oxy]methyl 1-methylethyl ester; Tenofovir Disoproxil Fumarate IP Impurity L. Grade: ≥95%. Molecular formula: C18H29N6O9P. Mole weight: 504.44. BOC Sciences 7
Diroximel fumarate Diroximel fumarate (ALKS 8700) is an orally-active and well-tolerated monomethyl fumarate (MMF) proagent in a controlled-release formulation. Diroximel fumarate is considered as active equivalent to its active metabolite dimethyl fumarate (DMF). Diroximel fumarate has a favorable safety and efficacy profile, has the potential for the study of multiple sclerosis (MS). Diroximel fumarate is a Nrf2 activator that alleviate MGO-induced pain hypersensitivity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ALKS 8700; BIIB098. CAS No. 1577222-14-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100375. MedChemExpress MCE
(E)-Olopatadine fumarate salt An impurity of Olopatadine, which is a histamine blocker and mast cell stabilizer. Synonyms: Dibenz[b,e]oxepin-2-acetic acid, 11-[3-(dimethylamino)propylidene]-6,11-dihydro-, (11E)-, (2E)-2-butenedioate (1:1); Dibenz[b,e]oxepin-2-acetic acid, 11-[3-(dimethylamino)propylidene]-6,11-dihydro-, (E)-, (E)-2-butenedioate (1:1); (11E)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid fumarate salt. Grade: ≥95%. CAS No. 113836-21-8. Molecular formula: C21H23NO3.C4H4O4. Mole weight: 453.49. BOC Sciences 3
Fumarprotocetraric acid Fumarprotocetraric acid is originally isolated from Cetraria islandica. Synonyms: Fumarylprotocetraric acid; NSC-249984; NCGC00095467-02; [(7-carboxy-4-formyl-3,8-dihydroxy-1,6-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepin-9-yl)methyl] hydrogen fumarate. Grade: >95%. CAS No. 489-50-9. Molecular formula: C22H16O12. Mole weight: 472.35. BOC Sciences 12
Methapyrilene-[d6] fumarate Methapyrilene-[d6] fumarate is the labelled salt of Methapyrilene, which is used as an antihistamine and anticholinergic. Synonyms: Methapyrilene-D6 fumarate; N,N-Dimethyl-D6-N'-(2-pyridyl)-N'-(2-thienylmethyl)-1,2-ethandiamine fumarate; Methapyrilene-(dimethyl-d6) fumarate salt; Thenylpyramine-d6 fumarate; Paradormalene-d6 fumarate; Lullamin-d6 fumarate; Pyrathyn-d6 fumarate; Pyrinistab-d6 fumarate; Pyrinistol-d6 fumarate. Grade: 95% by HPLC; 98% atom D. CAS No. 1613439-61-4. Molecular formula: C14D6H13N3S.C4H4O4. Mole weight: 383.49. BOC Sciences 2
Monomethyl fumarate Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2756-87-8. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-103252. MedChemExpress MCE
O-Acetyl Psilocin-d4 Fumarate O-Acetyl Psilocin-d4 Fumarate. Group: Biochemicals. Alternative Names: 3-[2-(Dimethylamino)ethyl-d4]-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. USBiological 3
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tert-Butyl ethylfumarate tert-Butyl ethylfumarate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 100922-16-5, 2-Butenedioic acid(2E)-, 1-(1,1-dimethylethyl) 4-ethyl ester, ACMC-20m3yv, TERT-BUTYLETHYLFUMARATE, CTK3J9359, AG-D-06843, 2-Butenedioicacid (2E)-, 1,1-dimethylethyl ethyl ester (9CI); 2-Butenedioic acid (E)-,1,1-dimethylethyl ethyl ester; (E)-tert-Butyl ethyl butenedioate; Fumaric acidtert-butyl ethyl ester; tert-Butyl ethyl fumarate. Product Category: Heterocyclic Organic Compound. CAS No. 100922-16-5. Molecular formula: C10H14O4-2. Mole weight: 198.215760 [g/mol]. Purity: 0.96. IUPACName: 2-tert-butyl-3-ethylbut-2-enedioate. Canonical SMILES: CCC(=C(C(=O)[O-])C(C)(C)C)C(=O)[O-]. Product ID: ACM100922165. Alfa Chemistry — ISO 9001:2015 Certified. Alfa Chemistry. 5
trans-1,2-Ethylenedicarboxylic Acid trans-1,2-Ethylenedicarboxylic Acid. Group: Biochemicals. Alternative Names: (2E)-2-Butenedioic Acid 1,4-Dimethyl Ester; (E)-2-Butenedioic Acid 1,4-Dimethyl Ester; Fumaric Acid Dimethyl Ester; (2E)-2-Butenedioic Acid Dimethyl Ester; (E)-But-2-enedioic Acid Dimethyl Ester; AZL-O 211089; Allomaleic Acid Dimethyl Ester; BG 00012; Boletic Acid Dimethyl Ester; Dimethyl (E)-2-Butenedioate; Dimethyl (E)-Butenedioate; Dimethyl Fumarate; Dimethyl trans-Ethylenedicarboxylate; Methyl Fumarate; NSC 167432; NSC 25942; trans-1,2-Ethylenedicarboxylic Acid Dimethyl Ester; trans-Butenedioic Acid Dimethyl Ester. Grades: Highly Purified. CAS No. 624-49-7. Pack Sizes: 10g. Molecular Formula: C6H8O4, Molecular Weight: 144.13. US Biological Life Sciences. USBiological 4
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Fumaraldehyde bis(dimethyl acetal) Fumaraldehyde bis(dimethyl acetal). Uses: Designed for use in research and industrial production. Product Category: Ortho Esters. CAS No. 6068-62-8. Molecular formula: C8H16O4. Mole weight: 176.21. Product ID: ACM6068628. Alfa Chemistry — ISO 9001:2015 Certified. Categories: (2E)-1,1,4,4-tetramethoxybut-2-ene. Alfa Chemistry. 2
Fumaric Acid tert-Butyl Ester Fumaric Acid tert-Butyl Ester is a tert-Butyl ester derivative of Fumaric Acid (F500380). Fumaric Acid tert-Butyl Ester is a reactant used in the preparation of cysteine protease inhibitors based on fumaric acid-derived oligopeptides. It is also used in the preparation of Nε-fumaroylated diketopiperazine of L-Lys used for pulmonary drug delivery. Group: Biochemicals. Alternative Names: (2E)-2-Butenedioic Acid Mono(1,1-dimethylethyl) Ester; (E)-4-tert-Butoxy-4-oxobut-2-enoic Acid. Grades: Highly Purified. CAS No. 135355-96-3. Pack Sizes: 500mg. US Biological Life Sciences. USBiological 3
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Fumaric Acid tert-Butyl Ester Fumaric Acid tert-Butyl Ester is a tert-butyl ester derivative of Fumaric acid, which is a drug used to treat the autoimmune condition psoriasis. It is also used as a food additive. Synonyms: (2E)-2-Butenedioic Acid Mono(1,1-dimethylethyl) Ester; (E)-4-tert-Butoxy-4-oxobut-2-enoic Acid; Fumaric acid mono-tert-butyl ester; (E)-4-(Tert-butoxy)-4-oxobut-2-enoic acid; 2-Butenedioic acid, mono(1,1-dimethylethyl)ester, (2E)-. Grade: 95%. CAS No. 135355-96-3. Molecular formula: C8H12O4. Mole weight: 172.18. BOC Sciences 8
N- (2-N’, N’-Dimethylaminoethyl) fumaramic Acid N- (2-N’, N’-Dimethylaminoethyl) fumaramic Acid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250mg. US Biological Life Sciences. USBiological 1
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