Dipeptidase Suppliers USA
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Product | Description | |
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2-PMPA Quick inquiry Where to buy Suppliers range | 2-PMPA is a highly potent and selective inhibitor of glutamate carboxypeptidase 2 (Ki= 275 pM) and the neuropeptidase N-acetylated α-linked acidic dipeptidase (NAALADase). Synonyms: 2-(phosphonomethyl)pentanedioic acid; 2-PMPA cpd; 2-PMPA; 2PMPA; 2PMPA. CAS No. 173039-10-6. Molecular formula: C6H11O7P. Mole weight: 226.12. | |
Cilastatin Quick inquiry Where to buy Suppliers range | Prevents renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. Antibacterial adjunct.Cilastatin is an inhibitor of dipeptidase (dehydropeptidase I), a renal dipeptidase.1 It inhibits human renal dipeptidase (Ki = 0.7uM), porcine dipeptidase (IC50 = 0.11uM), and bacterial metallo- β-lactamase CphA from A. hydrophila (IC50 = 178uM).1,2,3 Cilastatin (200ug/ml) protects primary porcine renal proximal tubular epithelial cells from nephrotoxicity and apoptosis induced by vancomycin.4 In a mouse model of systemic infection, cilastatin in combination with imipenem protects mice from S. aureus, E. coli, and P. aeruginosa infection.5 Cilastatin was designed to inhibit renal metabolism of imipenem and prolong its half-life.2 Formulations containing cilastatin in combination with imipenem have been used to treat susceptible bacterial infections. Group: Biochemicals. Alternative Names: (2Z) -7- [ [ (2R) -2-amino-2-carboxyethyl] thio] -2- [ [ [ (1S) -2, 2-dimethylcyclopropyl] carbonyl] amino] -2-heptenoic Acid; MK-791. Grades: Highly Purified. CAS No. 82009-34-5. Pack Sizes: 10mg, 25mg, 50mg, 100mg. Molecular Formula: C??H??N?O?S, Molecular Weight: 358.45. US Biological Life Sciences. | Worldwide |
Cilastatin Ammonium Salt Quick inquiry Where to buy Suppliers range | Cilastatin Ammonium Salt is the ammonium salt of Cilastatin, which is a dipeptidase inhibitor of renal enzyme dehydropeptidase-I and leukotriene D4 peptidase. It inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. It reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells. It can be combined intravenously with imipenem in order to protect it from dehydropeptidase. It suppresses both host and target metabolism of the broad-spectrum antibiotic imipenem, improving its efficacy. It usually confers antibiotic resistance to certain bacteria because itself does not have antibiotic activity. It has nephroprotective effects. Synonyms: (2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic Acid Ammonium Salt; MK-791 Ammonium Salt. Grades: > 95%. CAS No. 877674-82-3. Molecular formula: C16H29N3O5S. Mole weight: 375.48. | |
Cilastatin sodium Quick inquiry Where to buy Suppliers range | Cilastatin sodium is the sodium salt of cilastatin, which is a dipeptidase inhibitor of renal enzyme dehydropeptidase-I and leukotriene D4 peptidase. It inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. It reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells. It can be combined intravenously with imipenem in order to protect it from dehydropeptidase. It suppresses both host and target metabolism of the broad-spectrum antibiotic imipenem, improving its efficacy. It usually confers antibiotic resistance to certain bacteria because itself does not have antibiotic activity. It has nephroprotective effects. Synonyms: L 642957; MK 791; L642957; MK791; L-642957; MK-791; [R-[R*,S*-(Z)]]-7-[(2-Amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-2-heptenoic Acid Monosodium Salt; (2Z) ?-7- [ [ (2R) ?-2-Amino-2-carboxyethyl] ?thio] ?-2- [ [ [ (1S) ?-2, ?2-dimethylcyclopropyl] ?carbonyl] ?amino] ?-2-heptenoic Acid Sodium Salt; sodium S-((Z)-6-carboxy-6-((S)-2,2-dimethylcyclopropane-1-carboxamido)hex-5-en-1-yl)-L-cysteinate. Grades: ≥99% by HPLC. CAS No. 81129-83-1. Molecular formula: C16H25N2NaO5S. Mole weight: 380.43. | |
Cysteinyl-3M3SH Quick inquiry Where to buy Suppliers range | Cysteinyl-3M3SH is an intermediate in the bacterial biotransformation of the odourless physiological malodour precursor Cys-Gly-3M3SH. Cys-Gly-3M3SH is actively transported by the di-/tri-peptide transporter (DtpT) along with the movement of protons. Once inside the cell the terminal glycine is cleaved by a dipeptidase (PepA) to release Cys-3M3SH. Synonyms: Cys-3M3SH. Molecular formula: C10H21NO3S. Mole weight: 235.34. | |
Epostatin Quick inquiry Where to buy Suppliers range | Epostatin is a dipeptidase II inhibitor produced by Streptomyces sp. MJ 995-OF5. It can inhibit DPP-II with an IC50 of 9.6 μg/mL, and has a weak inhibitory effect on other dipeptidase peptidases. Synonyms: L-Glutamine, N(sup 2)- (4- (2-hexyl-2, 3, 4, 4a-tetrahydrocyclopent (b)oxireno (c)pyridin-7 (1aH)-ylidene)-1-oxo-2-butenyl)-. Grades: >98%. CAS No. 181372-99-6. Molecular formula: C23H33N3O5. Mole weight: 431.52. | |
Gly-Leu (Glycyl-L-leucine) Quick inquiry Where to buy Suppliers range | Substrate for the assay of glycyl-L-leucine dipeptidase. Group: Biochemicals. Alternative Names: Glycyl-L-leucine. Grades: Highly Purified. CAS No. 869-19-2. Pack Sizes: 10g. US Biological Life Sciences. | Worldwide |
L-Prolyl-L-alanine Quick inquiry Where to buy Suppliers range | Substrate for human kidney prolinase (prolyl dipeptidase). Synonyms: Pro-Ala-OH; Pro Ala OH. Grades: ≥ 99% (TLC). CAS No. 6422-36-2. Molecular formula: C8H14N2O3. Mole weight: 186.21. | |
L-Propyl-L-valine Quick inquiry Where to buy Suppliers range | A substrate for human kidney prolinase (prolyl dipeptidase). Synonyms: pro-val; PV dipeptide; Proline Valine dipeptide; (S)-3-Methyl-2-((S)-pyrrolidine-2-carboxamido)butanoic acid. CAS No. 52899-09-9. Molecular formula: C10H18N2O3. Mole weight: 214.26. | |
PMPA sodium salt Quick inquiry Where to buy Suppliers range | PMPA is an inhibitor of glutamate carboxypeptidase 2 (GCP II/N-acetylated a-linked dipeptidase/NAALADase). Synonyms: PMPA tetrasodium. CAS No. 373645-42-2. Molecular formula: C6H7Na4O7P. Mole weight: 314.05. | |
Pro-Gly-OH Quick inquiry Where to buy Suppliers range | Substrate for prolinase (prolyl dipeptidase). Synonyms: (S)-2-(pyrrolidine-2-carboxamido)acetic acid; [(Pyrrolidine-2-carbonyl)-amino]-acetic acid; Pro Gly OH. Grades: ≥ 95% (HPLC). CAS No. 2578-57-6. Molecular formula: C7H12N2O3. Mole weight: 172.18. | |
Ser-Leu Quick inquiry Where to buy Suppliers range | A substrate for human kidney dipeptidase. Synonyms: seryl-leucine; L-seryl-L-leucine; 4-fluoro-N-[[4-[[ (4-fluorophenyl) amino]methyl]phenyl]methyl]aniline; SL dipeptide; L-Ser-L-Leu; Serine Leucine dipeptide. CAS No. 6665-16-3. Molecular formula: C9H18N2O4. Mole weight: 218.25. | |
Ubenimex Quick inquiry Where to buy Suppliers range | Ubenimex (INN), also known more commonly as bestatin, is a competitive, reversible protease inhibitor. It is an inhibitor of arginyl aminopeptidase (aminopeptidase B), leukotriene A4 hydrolase (a zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities), alanyl aminopeptidase (aminopeptidase M/N), leucyl/cystinyl aminopeptidase (oxytocinase/vasopressinase), and membrane dipeptidase (leukotriene D4 hydrolase). It is being studied for use in the treatment of acute myelocytic leukemia. It is derived from Streptomyces olivoreticuli. Ubenimex has been found to inhibit the enzymatic degradation of oxytocin, vasopressin, enkephalins, and various other peptides and compounds. Group: Main Products. Alternative Names: 3-(r)-amino-2-(s)-hydroxy-4-phenylbutanoyl-(s)-leucine;n-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-,(s-(r*,s*))-l-leucin;nk421;UBENIMEX;N-[(2S,3R)-3-AMINO-2-HYDROXY-1-OXO-4-PHENYLBUTYL]-L-LEUCINE;N-((2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL)-L-LEUCINE;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL]-L-LEUCINE;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-LEU. Grades: 99%. CAS No. 58970-76-6. Product ID: ACM58970766. Molecular formula: C16H24N2O4. Mole weight: 308.37. IUPAC Name: (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoicacid. Appearance: White crystalline powder. EC Number: 261-529-2. Boiling Point: 604.7ºC at 760 mmHg. Melting Point: 245ºC. Flash Point: 319.5ºC. Density: 1.197 g/cm³. |