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| Product | Description | |
|---|---|---|
| DNA helicase | DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. Some of them unwind duplex DNA with a 3' to 5' polarity, others show 5' to 3' polarity or unwind DNA in both directions. Some helicases unwind DNA as well as RNA. May be identical with EC 3.6.4.13 (RNA helicase). Group: Enzymes. Synonyms: 3' to 5' DNA helicase; 3'-5' DNA helicase; 3'-5' PfDH; 5' to 3' DNA helicase; AvDH1; BACH1 helicase; BcMCM; BLM protein; BRCA1-associated C-terminal helicase; CeWRN-1; Dbp9p; DmRECQ5; DNA helicase 120; DNA helicase A; DNA helicase E; DNA helicase I. Enzyme Commission Number: EC 3.6.4.12. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4702; DNA helicase; EC 3.6.4.12; 3' to 5' DNA helicase; 3'-5' DNA helicase; 3'-5' PfDH; 5' to 3' DNA helicase; AvDH1; BACH1 helicase; BcMCM; BLM protein; BRCA1-associated C-terminal helicase; CeWRN-1; Dbp9p; DmRECQ5; DNA helicase 120; DNA helicase A; DNA helicase E; DNA helicase II; DNA helicase III; DNA helicase RECQL5β; DNA helicase VI; dnaB; DnaB helicase E1; helicase HDH IV; Hel E; helicase DnaB; helicase domain of bacteriophage T7 gene 4 protein helicase; PcrA helicase; UvrD; hHcsA; Hmi1p; hPif1; MCM helicase; MCM protein; MER3 helicase; MER3 protein; MPH1; PcrA; PcrA helicase; PDH120; PfDH A; Pfh1p; PIF1. Cat No: EXWM-4702. |  |
| 7-Propargylamino-7-deaza-ddGTP - ATTO-633 | 7-Propargylamino-7-deaza-ddGTP - ATTO-633, a fluorescent nucleotide analog, is a product of great importance in biomedical research, specializing in studying DNA replication and repair mechanisms. Its usage is specifically geared towards single-molecule fluorescence-based assays in analyzing the behaviors of DNA polymerases and helicases. Enabling the detection of DNA damage-related diseases like cancer, this product is ideal due to its unique fluorescence properties. Synonyms: 7-Deaza-7-propargylamino-2',3'-dideoxyguanosine-5'-triphosphate, labeled with ATTO 633, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C14H20N5O12P3- ATTO 633 (free acid). Mole weight: 1076.26 (free acid). |  |
| Amenamevir | Amenamevir is a DNA helicase-primase inhibitor. It has anti-HSV activity against herpes simplex keratitis. In Mar 2016, Mahuro completed a phase III trial in Herpes simplex virus infections in Japan. Uses: Herpes simplex virus infections; herpes zoster. Synonyms: UNII-94X46KW4AE; ASP2151; N-(2,6-dimethylphenyl)-N-[2-[4-(1,2,4-oxadiazol-3-yl)anilino]-2-oxoethyl]-1,1-dioxothiane-4-carboxamide. Grade: 98%. CAS No. 841301-32-4. Molecular formula: C24H26N4O5S. Mole weight: 482.55. | |
| BLM Helicase Inhibitor, ML216 (ML-216, 1- (4-Fluoro-3- (trifluoromethyl) phenyl) -3- (5- (pyridin-4-yl) -1, 3, 4-thiadiazol-2-yl) urea) | A cell-permeable pyridinyl-thiadiazolylurea compound that selectively blocks Bloom's syndrome protein (BLM) helicase activity of both full-length as well as truncated BLM636-1298 forms (IC50 = 2.98 and 0.97uM, respectively). Competes with and reversibly blocks DNA binding to BLM. However, the inhibition appears to be non-competitive with respect to ATP. Exhibits anti-proliferative activity in cells expressing BLM, but not in those lacking BLM. Induces sister chromatid exchanges (SCEs) and enhances the sensitivity of BLM containing PSNF5 cells to aphidicolin without affecting PSNG13 cells that are devoid of BLM. Displays favorable microsomal (T1/2 > 1.2h) and plasma stability (~100% at 5h). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H?F?N?OS. US Biological Life Sciences. |  Worldwide |
| CGI-55 protein (21-31) | CGI-55 protein (21-31) is a bioactive peptide of CGI-55 protein. The human protein CGI-55 has been described as a chromo-helicase-DNA-binding domain protein (CHD)-3 interacting protein and was also found to interact with the 3'-region of the plasminogen activator inhibitor (PAI)-1 mRNA. | |
| Cyclothialidine | It is produced by the strain of Streptomyces filipinensis NR 0484. It and its homologues inhibit escherichia coli DNA helicases with IC50 of 0.3 μmol/L, and the reference neomycin was 1.2 μmol/L. Synonyms: Cyclothialidine A; (2S)-2-[[(5S,8R)-5-[[(2S,3R)-1-(2-amino-3-hydroxypropanoyl)-3-hydroxypyrrolidine-2-carbonyl]amino]-13,15-dihydroxy-16-methyl-2,6-dioxo3-oxa-10-thia-7-azabicyclo[10.4.0]hexadeca-1(16),12,14-triene-8-carbonyl]amino]propanoic acid; N-[[(4R,7S)-1,3,4,5,6,7,8,10-octahydro-12,14-dihydroxy-7-[[(3R)-3-hydroxy-1-L-seryl-L-prolyl]amino]-11-methyl-6,10-dioxo-9,2,5-benzoxathiaazacyclododecin-4-yl]carbonyl]-L-alanine. CAS No. 147214-63-9. Molecular formula: C26H35N5O12S. Mole weight: 641.65. | |
| Cyclothialidine B | It is produced by the strain of Streptomyces sp. NR 0659. It and its homologues inhibit escherichia coli DNA helicases with IC50 of 0.7 μmol/L, and the reference neomycin was 1.2 μmol/L. CAS No. 194276-76-1. Molecular formula: C25H33N5O11S. Mole weight: 611.62. | |
| Cyclothialidine C | It is produced by the strain of Streptomyces sp. NR 0659. It and its homologues inhibit escherichia coli DNA helicases with IC50 of 0.7 μmol/L, and the reference neomycin was 1.2 μmol/L. CAS No. 161161-54-2. Molecular formula: C26H35N5O11S. Mole weight: 625.66. | |
| Cyclothialidine D | It is produced by the strain of Streptomyces sp. NR 0659. It and its homologues inhibit escherichia coli DNA helicases with IC50 of 0.7 μmol/L, and the reference neomycin was 1.2 μmol/L. CAS No. 194276-78-3. Molecular formula: C24H31N5O11S. Mole weight: 597.60. | |
| Cyclothialidine E | It is produced by the strain of Streptomyces sp. NR 0659. It and its homologues inhibit escherichia coli DNA helicases with IC50 of 0.7 μmol/L, and the reference neomycin was 1.2 μmol/L. CAS No. 194276-79-4. Molecular formula: C25H33N5O11S. Mole weight: 611.63. | |
| DNA2 inhibitor C5 | DNA2 inhibitor C5 is a potent, competitive, and specific DNA2 nuclease inhibitor with an IC50 of 20 ?M. DNA2 inhibitor C5 inhibits the nuclease, DNA-dependent ATPase, helicase, and DNA-binding activities of DNA2. DNA2 inhibitor C5 can be used in breast cancer and colorectal cancer research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 35973-25-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128729. |  |
| EDA-ATPγS - ATTO-495 | EDA-ATPγS - ATTO-495, a fluorescent substrate, finds utility in intermolecular crosslinking studies and biomedicine for detecting binding patterns of cytoskeletal motors, ATPases, and DNA helicases. Its versatile applications include neurological disorder investigation, notably Alzheimer's disease and Parkinson's disease. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-adenosine-5'-(γ-thio)-triphosphate, labeled with ATTO 495, Triethylammonium salt. Grade: ≥ 90 % by HPLC, contains approx. 5 % EDA-ADP-dye. Molecular formula: C34H45N10O14P3S (free acid). Mole weight: 942.77 (free acid). | |
| EDA-GTP - 5-FAM | EDA-GTP - 5-FAM is a fluorescently-labeled nucleotide analog widely used in biomedical field for studying DNA synthesis, repair and replication processes. It serves as a suitable substrate for DNA polymerases and helicases, enabling the visualization and analysis of nucleotide incorporation and DNA synthesis dynamics. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Guanosine-5'-triphosphate, labeled with 5 FAM, Triethylammonium salt. Grade: ≥ 95 % by HPLC. Molecular formula: C34H32N7O21P3(free acid). Mole weight: 967.28 (free acid). | |
| Fanconi anemia group M protein (201-214) | Fanconi anemia group M protein (201-214) is a bioactive peptide of Fanconi anemia group M protein. It is believed that FACM in conjunction with other Fanconi anemia- proteins repair DNA at stalled replication forks, and stalled transcription structures called R-loops. Synonyms: Protein FACM (201-214); ATP-dependent RNA helicase FANCM (201-214). | |
| GSK4418959 | GSK4418959 (IDE275) is a non-covalent, reversible, selective and orally active WRN helicase inhibitor. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IDE275. CAS No. 3064599-36-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-169422. | |
| Heliquinomycin | It is produced by the strain of Streptomyces sp. MJ929-SF2. It has anti-DNA helicase activity with Ki value of 6.8 X 10-6 mol/L. It has strong anti-gram-positive bacteria (including MR-SA) activity (MIC is 0.05-0.39 μg/mL), but has no effect on gram-negative bacteria and fungi. It has anti-tumor activity on HeLa S3, L1210, IMC, B16 and FS-3 cells with IC50 (μg/mL) of 1.6, 0.97, 1.56, 0.88 and 0.83, respectively. Its acute toxicity is low, LD50 is 100 mg/kg (mouse, enterocoelia). Synonyms: NSC 702208; Rubymycin. Grade: >95%. CAS No. 178182-49-5. Molecular formula: C33H30O17. Mole weight: 698.58. | |
| Heliquinomycin (Rubymycin, NSC 702208) | Antibiotic. DNA helicase inhibitor. Inhibits the DNA helicase activity of the human minichromosome maintenance (MCM) 4/6/7 complex. Topoisomerase I and II inhibitor (weaker than DNA helicase). DNA and RNA synthesis inhibitor in cell culture. Does not inhibit protein synthesis. Induces cell cycle arrest. Anticancer compound. Antibacterial against Gram-positive bacteria. Group: Biochemicals. Grades: Purified. CAS No. 178182-49-5. Pack Sizes: 250ug, 500ug. Molecular Formula: C33H30O17. US Biological Life Sciences. | Worldwide |
| HRO761 | HRO761 (Werner syndrome RecQ helicase-IN-1) (example 42) is a potent Werner syndrome RecQ DNA helicase enzyme ( WRN ) inhibitor and can be used in cancer research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Werner syndrome RecQ helicase-IN-1. CAS No. 2869954-34-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-148699. | |
| ML216 | ML216 (CID-49852229) is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC50s of 2.98 ?M and 0.97 ?M for BLMfull-length and BLM636-1298, respectively. ML216 inhibits ssDNA-dependent ATPase activity of BLM with a Ki of 1.76 ?M. Antitumor avtivity[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID-49852229. CAS No. 1430213-30-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12342. | |
| Norfloxacin | Norfloxacin and ofloxacin, levofloxacin, ciprofloxacin belong to the third generation fluoroquinolone antibacterial drugs, with a broad spectrum of antibacterial action, especially against aerobic gram-negative bacteria with high antibacterial activity, against the following bacteria in vitro has a good antibacterial effect: Most of the bacteria in the Enterobacteriaceae family, including E. coli, Enterobacter cloacae, Enterobacter aerogenes, E. coli, Klebsiella, Chemicalbook Proteus, Salmonella, Shigella, Vibrio, Yersinia, etc. Norfloxacin also has antibacterial activity against multi-drug resistant bacteria in vitro. The penicillin-resistant Neisseria gonorrhoeae, Haemophilus influenzae and Moraxella catarrh also have good antibacterial effects. Norfloxacin is A bactericide that causes bacterial death by inhibiting DNA synthesis and replication by acting on the A subunit of bacterial DNA helicase. CAS No. 70458-96-7. Product ID: PAP-0063. Molecular formula: C16H18FN3O3. Category: Antibiotic. Product Keywords: Antibacterial, Anti-inflammatory and Antiviral Series; Norfloxacin; PAP-0063; Antibiotic; C16H18FN3O3; 70458-96-7. Appearance: Crystalline Powder. Standard: USP. Grade: CEP/ISO. Color: White to yellow. Physical State: Crystalline Powder. Solubility: Very slightly soluble in water, slightly soluble in acetone and in ethanol (96 per cent). Storage: Keep in dark place,Sealed in dry,Room Temperature. Applications: C |  |
| PHA 767491 Dihydrochloride Salt | A potent and selective ATP-competitive dual inhibitor cdc7/cdk9. It blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites. Inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo. Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2). Group: Biochemicals. Alternative Names: 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one Dihydrochloride;PHA 767491 Dihydrochloride Salt; PF-02334471. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| PolQi2 | PolQi2 is a Pol? inhibitor that targets and inhibits alt-EJ (alternative end-joining) repair by inhibiting the helicase domain at the N-terminus of Pol?. PolQi2 enhances the precision and integration efficiency of gene editing at different loci and in various cell lines. Furthermore, the combined use of PolQi2 with DNA-PK inhibitors reduces the off-target effects of Cas9. PolQi2 can be used in gene editing research[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2565638-16-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150279. | |
| Polθ-IN-4 | Polθ-IN-4 (Example 1) is a DNA polymerase theta ( Polθ ) inhibitor that inhibits Polθ activity by targeting its ATP-dependent helicase domain. Polθ-IN-4 can be utilized in cancer research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3043810-73-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161916. | |
| ribonuclease E | RNase E is a bacterial ribonuclease that plays a role in the processing of ribosomal RNA (9S to 5S rRNA), the chemical degradation of bulk cellular RNA, the decay of specific regulatory, messenger and structural RNAs and the control of plasmid DNA replication. The enzyme binds to monophosphorylated 5' ends of substrates but exhibits sequential cleavages in the 3' to 5' direction. 2'-O-Methyl nucleotide substitutions at RNase E binding sites do not prevent binding but do prevent cleavage of non-modified target sequences 5' to that locus. In Escherichia coli, the enzyme is found in the RNA degradosome. The C-terminal half of the protein contains binding sites for the three other major degradosomal components, the DEAD-box RNA helicase Rh1B, enolase (EC 4.1.1.11) and polynucleotide phosphorylase (EC 2.7.7.8). Group: Enzymes. Synonyms: endoribonuclease E; RNase E; Rne protein. Enzyme Commission Number: EC 3.1.26.12. CAS No. 76106-82-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3588; ribonuclease E; EC 3.1.26.12; 76106-82-6; endoribonuclease E; RNase E; Rne protein. Cat No: EXWM-3588. | |
| RNA helicase | RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. Some helicases unwind DNA as well as RNA. May be identical with EC 3.6.4.12 (DNA helicase). Group: Enzymes. Synonyms: CSFV NS3 helicase; DBP2; DbpA; DDX17; DDX25; DDX3; DDX3X; DDX3Y; DDX4; DDX5; DEAD-box protein DED1; DEAD-box RNA helicase; DEAH-box protein 2; DEAH-box RNA helicase; DED1; Dex(H/D) RNA helicase; EhDEAD1; EhDEAD1 RNA helicase; eIF4A helicase; KOKV helicase; Mtr4p; nonstructural protein 3 helicase; NPH-II; RHA; RNA helicase A; RNA helicase DDX3; RNA helicase Hera; RNA-dependent ATPase; TGBp1 NTPase/helicase domain; VRH1; GRTH/DDX25. Enzyme Commission Number: EC 3.6.4.13. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4703; RNA helicase; EC 3.6.4.13; CSFV NS3 helicase; DBP2; DbpA; DDX17; DDX25; DDX3; DDX3X; DDX3Y; DDX4; DDX5; DEAD-box protein DED1; DEAD-box RNA helicase; DEAH-box protein 2; DEAH-box RNA helicase; DED1; Dex(H/D) RNA helicase; EhDEAD1; EhDEAD1 RNA helicase; eIF4A helicase; KOKV helicase; Mtr4p; nonstructural protein 3 helicase; NPH-II; RHA; RNA helicase A; RNA helicase DDX3; RNA helicase Hera; RNA-dependent ATPase; TGBp1 NTPase/helicase domain; VRH1; GRTH/DDX25. Cat No: EXWM-4703. | |
| VVD-214 | VVD-214 is a synthetic lethal allosteric inhibitor of WRN helicase with an IC50 of 0.1316 μM. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RO7589831; VVD-133214. CAS No. 3026500-20-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158116. | |
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