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| Product | Description | |
|---|---|---|
| Dolastatin 10 | Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization. Uses: Scientific research. Group: Peptides. Alternative Names: DLS 10; NSC 376128. CAS No. 110417-88-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15580. |  |
| Dolastatin 10 | Dolastatin 10 is a potent antimitotic peptide from a marine animal, strongly inhibiting microtubule assembly. Uses: Adcs cytotoxin. Synonyms: DLS 10; NSC 376128; Dolastatin-10; DLS-10; DLS10; NSC376128; NSC-376128; L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1-methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-,[2S-[1[1R*(R*),2S*],2R*[1S*,2S*,3(R*)]]]-. Grades: >98%. CAS No. 110417-88-4. Molecular formula: C42H68N6O6S. Mole weight: 785.09. |  |
| Dolastatin 10 trifluoroacetate | Dolastatin 10 trifluoroacetate inhibits tubulin polymerization and induces tubulin aggregation in vitro. Synonyms: Dolastatin 10 trifluoroacetate; 2342568-65-2; EX-A8176; AKOS027470141; AKOS040745145; PD080063; Dolastatin 10 trifluoroacetate (110417-88-4 free base); (2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-N-[(3R,4S,5S)-3-methoxy-1-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide; 2,2,2-trifluoroacetic acid; N,N-Dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazol)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl--valinamide trifluoroacetate. CAS No. 2342568-65-2. Molecular formula: C42H68N6O6S.CF3CO2H. Mole weight: 899.11. | |
| Auristatin E | Auristatin E is a synthetic analog of dolastatin 10. Auristatin E is a highly potent antimitotic agent.Auristatin E inhibits tubulin polymerization. Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity. Uses: Adcs cytotoxin. Synonyms: Auristatin E. Grades: ≥96.0% (HPLC). CAS No. 160800-57-7. Molecular formula: C40H69N5O7. Mole weight: 732.01. | |
| Auristatin F | Auristatin F, a synthetic analog of dolastatin 10, is a cytotoxic tubulin modifier with potent and selective antitumor activity. It is an MMAF analog and cytotoxin in Antibody-drug conjugates. Uses: Adcs cytotoxin. Synonyms: N,N-Dimethyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-L-phenylalanine; L-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-; N,N-Dimethyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl}-3-methoxy-5-methyl-1-oxo-4-heptanyl]-N-methyl-L-valinamide. Grades: ≥97% by HPLC. CAS No. 163768-50-1. Molecular formula: C40H67N5O8. Mole weight: 745.99. | |
| Cemadotin | Cemadotin is a synthetic analogue of Dolastatin 15 with potent antiproliferative and preclinical antitumor activity. It is also a promising cancer chemotherapeutic agent. Synonyms: LU 103793; LU-103793; LU103793; NSC D-669356; N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-L-prolinebenzylamide. CAS No. 159776-69-9. Molecular formula: C35H56N6O5. Mole weight: 640.87. | |
| Monomethyl auristatin E | Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MMAE; SGD-1010; Vedotin. CAS No. 474645-27-7. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-15162. | |
| Soblidotin | Soblidotin (TZT-1027) is a dolastatin-10 derivative. Soblidotin inhibits tubulin polymerization, resulting in cell cycle arrest and induction of apoptosis. TZT-1027 showed increased antitumor activity when combined with gemcitabine in animal models. Uses: Antineoplastic agents. Synonyms: Auristatin PE; NSC-654663; NSC 654663; NSC654663; TZT-1027; TZT 1027; TZT1027. Grades: 99%. CAS No. 149606-27-9. Molecular formula: C39H67N5O6. Mole weight: 701.99. | |
| Tasidotin hydrochloride | Tasidotin, also know as ILX-651, is an orally active synthetic microtubule-targeted derivative of the marine depsipeptide dolastatin-15, is currently undergoing clinical evaluation for cancer treatment. Tasidotin inhibited proliferation of MCF7/GFP breast cancer cells with an IC(50) of 63 nmol/L and inhibited mitosis with an IC(50) of 72 nmol/L in the absence of detectable effects on spindle microtubule polymer mass. Tasidotin inhibited the polymerization of purified tubulin into microtubules weakly (IC(50) approximately 30 micromol/L). However, it strongly suppressed the dynamic instability behavior of the microtubules at their plus ends at concentrations approximately 5 to 10 times below those required to inhibit polymerization. Synonyms: ILX 651; ILX651; ILX-651. CAS No. 623174-20-9. Molecular formula: C32H59ClN6O5. Mole weight: 643.31. | |
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