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| Product | Description | |
|---|---|---|
| Duocarmycin | Heterocyclic Organic Compound. CAS No. 118292-34-5. Molecular formula: C26H27N3O8. Mole weight: 509.51. Catalog: ACM118292345. |  |
| Duocarmycin A | It is produced by the strain of (Pyridamycin) Streptomyces sp. DO-88. It has strong antibacterial and antitumor activity. It can inhibit gram-positive bacteria such as Staphylococcus aureus and Streptococcus faecalis (MIC is less than 0.01 μg/mL), it can also inhibit klebsiella pneumoniae (MIC is 0.032 μg/mL), other bacteria and yeast (MIC is 1-10 μg/mL). Synonyms: Antibiotic DC 88A; methyl (6R,7bR,8aS)-6-methyl-4,7-dioxo-2-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-1,2,4,5,6,7,8,8a-octahydrocyclopropa[c]pyrrolo[3,2-e]indole-6-carboxylate; Methyl (2R,3bR,4aS)-2-methyl-3,8-dioxo-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-1,2,3,4,4a,5,6,8-octahydrocyclopropa[c]pyrrolo[3,2-e]indole-2-carboxylate; DUMA; (+)-Dunnione; (+)-duocarmycin A. Grades: ≥95%. CAS No. 118292-34-5. Molecular formula: C26H25N3O8. Mole weight: 507.49. |  |
| Duocarmycin Analog | Duocarmycin Analog is an analog of Duocarmycin, and used as an DNA alkylator and ADC cytotoxin [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 372954-15-9. Pack Sizes: 1 mg. Product ID: HY-129355. |  |
| Duocarmycin B1 | It is produced by the strain of (Pyridamycin) Streptomyces sp. DO-88. It has anti-gram-positive bacteria, gram-negative bacteria and tumor activity. Synonyms: Antibiotic DC 89B1; 1H-Pyrrolo3,2-fquinoline-2-carboxylic acid, 8-bromo-2,3,6,7,8,9-hexahydro-4-hydroxy-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl-, methyl ester, (2R,8S)-; Duocarmycin B(sub 1). Grades: ≥95%. CAS No. 124325-93-5. Molecular formula: C26H26BrN3O8. Mole weight: 588.40. | |
| Duocarmycin B2 | It is produced by the strain of (Pyridamycin) Streptomyces sp. DO-88. It has anti-tumor activity. Synonyms: DUMB2; Benzo1,2-b:4,3-bdipyrrole-2-carboxylic acid, 8-(bromomethyl)-1,2,3,6,7,8-hexahydro-4-hydroxy-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl-, methyl ester, (2R,8S)-. CAS No. 124325-94-6. Molecular formula: C26H26BrN3O8. Mole weight: 588.40. | |
| Duocarmycin SA | Duocarmycin SA is a potent antitumor antibiotic with an IC50 of 10 pM. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro. Synonyms: (+)-duocarmycin SA; Antibiotic DC113; methyl (1R, 12S)-7-oxo-10-(5, 6, 7-trimethoxy-1H-indole-2-carbonyl)-5, 10-diazatetracyclo[7.4.0.01, 12.02, 6]trideca-2(6), 3, 8-triene-4-carboxylate. Grades: 98.0%. CAS No. 130288-24-3. Molecular formula: C25H23N3O7. Mole weight: 477.47. | |
| 6-Chloro-2-hydroxy-quinoline-4-carboxylic acid | Heterocyclic Organic Compound. Alternative Names: Pyrindamycin B, duocarmycin C1, Antibiotic DC 89A1, C26H26ClN3O8, DC89-A1, DC 89-A1, BRN 5689373, CID133973, LS-21000, LS-139683, 1H-Pyrrolo(3,2-f)quinoline-2-carboxylic acid, 8-chloro-2,3,6,7,8,9-hexahydro-4-hydroxy-2-methyl-oxo-6-((5,6,7-trimethoxy-1H-indol-2-yl)carbonyl)-, methyl ester, 113189-05-2, 118292-35-6, 1H-Pyrrolo(3,2-f)quinoline-2-carboxylic acid, 8-chloro-2,3,6,7,8,9-hexahydro-4-hydroxy-2-methyl-1-oxo-6-((5,6,7-trimethoxy-1H-indol-2-yl)carbonyl)-, methyl ester. CAS No. 118292-35-6. Molecular formula: C10H6ClNO3. Mole weight: 223.61. Purity: 0.96. IUPACName: methyl (2R,8S)-8-chloro-4-hydroxy-7-methyl-1-oxo-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-3,7,8,9-tetrahydro-2H-pyrrolo[3,2-f]quinoline-2-carboxylate. Canonical SMILES: C1=CC2=C(C=C1Cl)C(=CC(=O)N2)C(=O)O. Catalog: ACM118292356. | |
| Adolezesin | Adozelesin is an experimental antitumor drug of the duocarmycin class. It is the first of a class of DNA-sequence-selective alkylating agents. It binds to and alkylates DNA, resulting in a reduction of both cellular and simian virus 40 (SV40) DNA replication which ultimately reduces the rate of cancer growth. It has marginal efficacy in the treatment of metastatic breast cancer at the dosage and schedule used in clinic phase 1 and 2 trials. It was developed by Pharmacia and was terminated in clinic phase 2 trials. Uses: Adozelesin has marginal efficacy in the treatment of metastatic breast cancer. Synonyms: U73975; U-73975; U 73975; N-(2-((7bR,8aS)-7-methyl-4-oxo-1,2,4,5,8,8a-hexahydrocyclopropa[c]pyrrolo[3,2-e]indole-2-carbonyl)-1H-indol-5-yl)benzofuran-2-carboxamide. Grades: >98%. CAS No. 110314-48-2. Molecular formula: C30H22N4O4. Mole weight: 502.52. | |
| Pyrindamycin A | Pyrindamycin A is an antibiotic produced by the strain of Streptomyces spp. It inhibits DNA synthesis and has the activity against gram-positive and gram-negative bacteria. It has antitumor activity against murine leukemia, shows stronger cytotoxic activities towards murine and human tumor cell lines and especially towards doxorubicin-resistant cells, inhibits P388 and P388/ADR cells with the same IC50 of 3.9 μg/ml. Synonyms: Duocarmycin C2; Antibiotic DC 89A2; Benzo(1,2-b:4,3-b')dipyrrole-2-carboxylic acid, 8-(chloromethyl)-1,2,3,6,7,8-hexahydro-4-hydroxy-2-methyl-1-oxo-6-((5,6,7-trimethoxy-1H-indol-2-yl)carbonyl)-, methyl ester, (2R-trans)-; Methyl (2R,8S)-8-(chloromethyl)-4-hydroxy-2-methyl-1-oxo-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-1,2,3,6,7,8-hexahydropyrrolo[3,2-e]indole-2-carboxylate; Antibiotic SF 2582A. Grades: ≥95%. CAS No. 118292-36-7. Molecular formula: C26H26ClN3O8. Mole weight: 543.95. | |
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