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| Product | Description | |
|---|---|---|
| Duocarmycin A | It is produced by the strain of (Pyridamycin) Streptomyces sp. DO-88. It has strong antibacterial and antitumor activity. It can inhibit gram-positive bacteria such as Staphylococcus aureus and Streptococcus faecalis (MIC is less than 0.01 μg/mL), it can also inhibit klebsiella pneumoniae (MIC is 0.032 μg/mL), other bacteria and yeast (MIC is 1-10 μg/mL). Synonyms: Antibiotic DC 88A; methyl (6R,7bR,8aS)-6-methyl-4,7-dioxo-2-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-1,2,4,5,6,7,8,8a-octahydrocyclopropa[c]pyrrolo[3,2-e]indole-6-carboxylate; Methyl (2R,3bR,4aS)-2-methyl-3,8-dioxo-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-1,2,3,4,4a,5,6,8-octahydrocyclopropa[c]pyrrolo[3,2-e]indole-2-carboxylate; DUMA; (+)-Dunnione; (+)-duocarmycin A. Grade: ≥95%. CAS No. 118292-34-5. Molecular formula: C26H25N3O8. Mole weight: 507.49. |  |
| Duocarmycin analog | Duocarmycin analog has cytotoxicity for solid tumor cells that can be used for antibody-drug conjugates (ADCs). Duocarmycins and the analogs acts via binding to the minor groove of DNA and alkylating the nucleobase adenine at the N3 position, which leads to DNA damage and cancer cell death. | |
| Duocarmycin Analog | Duocarmycin Analog is an analog of Duocarmycin, and used as an DNA alkylator and ADC cytotoxin [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 372954-15-9. Pack Sizes: 1 mg. Product ID: HY-129355. |  |
| Duocarmycin B1 | It is produced by the strain of (Pyridamycin) Streptomyces sp. DO-88. It has anti-gram-positive bacteria, gram-negative bacteria and tumor activity. Synonyms: Antibiotic DC 89B1; 1H-Pyrrolo3,2-fquinoline-2-carboxylic acid, 8-bromo-2,3,6,7,8,9-hexahydro-4-hydroxy-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl-, methyl ester, (2R,8S)-; Duocarmycin B(sub 1). Grade: ≥95%. CAS No. 124325-93-5. Molecular formula: C26H26BrN3O8. Mole weight: 588.40. | |
| Duocarmycin B2 | It is produced by the strain of (Pyridamycin) Streptomyces sp. DO-88. It has anti-tumor activity. Synonyms: DUMB2; Benzo1,2-b:4,3-bdipyrrole-2-carboxylic acid, 8-(bromomethyl)-1,2,3,6,7,8-hexahydro-4-hydroxy-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl-, methyl ester, (2R,8S)-. CAS No. 124325-94-6. Molecular formula: C26H26BrN3O8. Mole weight: 588.40. | |
| Duocarmycin DM | Duocarmycin DM is a DNA minor-groove alkylating agent, which can be used as an antibody drug conjugate (ADC) toxin. Duocarmycin DM is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity. Synonyms: (S)-(1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzo[e]indol-3-yl)(5-(2-(dimethylamino)ethoxy)-1H-indol-2-yl)methanone TFA. Grade: 95%. Molecular formula: C28H27ClF3N3O5. Mole weight: 577.98. | |
| Duocarmycin DM free base | Duocarmycin DM free base, a DNA minor-groove alkylator, is an antibody agent conjugates (ADCs) toxin. Duocarmycin DM free base is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1116745-06-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128915. | |
| Duocarmycin DM free base | Duocarmycin DM free base is a DNA minor-groove alkylating agent, which can be used as an antibody drug conjugate (ADC) toxin. Duocarmycin DM free base is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity. Synonyms: [(1S)-1-(Chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzo[e]indol-3-yl]{5-[2-(dimethylamino)ethoxy]-1H-indol-2-yl}methanone; Methanone, [(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl][5-[2-(dimethylamino)ethoxy]-1H-indol-2-yl]-. Grade: ≥97%. CAS No. 1116745-06-2. Molecular formula: C26H26ClN3O3. Mole weight: 463.96. | |
| Duocarmycin MB | Duocarmycin MB is an antibody drug conjugate (ADC) toxin that can be used against multidrug resistant cell lines. Duocarmycin is a DNA alkylating agent that binds in minor groove. Synonyms: Carbamic acid, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-6-yl]-, 1,1-dimethylethyl ester; 1,1-Dimethylethyl N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-6-yl]carbamate; 2-Methyl-2-propanyl (2-{[(1S)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzo[e]indol-3-yl]carbonyl}-1H-indol-6-yl)carbamate. Grade: ≥95%. CAS No. 1613286-58-0. Molecular formula: C27H26ClN3O4. Mole weight: 491.97. | |
| Duocarmycin SA | Duocarmycin SA is an orally active antitumor antibiotic with an IC50 of 10 pM[1]. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 130288-24-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-12456. | |
| MA-PEG4-vc-PAB-DMEA-duocarmycin DM | MA-PEG4-vc-PAB-DMEA-duocarmycin DM is a drug-linker conjugate for ADC by using Duocarmycin DM (a potent antitumor antibiotic), linked via MA-PEG4-vc-PAB-DMEA. Synonyms: Mal-PEG4-vc-PAB-DMEA-duocarmycin DM. Grade: 95%. Molecular formula: C68H89ClN12O17. Mole weight: 1381.98. | |
| MA-PEG4-vc-PAB-DMEA-duocarmycin SA | MA-PEG4-vc-PAB-DMEA-duocarmycin SA is a drug-linker conjugate for ADC by using Duocarmycin SA (a potent antitumor antibiotic), linked via MA-PEG4-vc-PAB-DMEA. Synonyms: Mal-PEG4-vc-PAB-DMEA-duocarmycin SA. Grade: 95%. Molecular formula: C67H87ClN12O21. Mole weight: 1431.94. | |
| Seco-Duocarmycin MB | Seco-Duocarmycin MB is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates. Synonyms: (S)-tert-butyl (2-(1-(chloromethyl)-5-hydroxy-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)-1H-indol-5-yl)carbamate. Grade: ≥95%. Molecular formula: C27H26ClN3O4. Mole weight: 491.97. | |
| Seco-Duocarmycin SA | Seco-Duocarmycin SA is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates. Synonyms: (S)-Methyl 8-(chloromethyl)-4-hydroxy-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-3,6,7,8-tetrahydropyrrolo[3,2-e]indole-2-carboxylate. Grade: ≥95%. CAS No. 152785-82-5. Molecular formula: C25H24ClN3O7. Mole weight: 513.93. | |
| Seco-Duocarmycin TM | Seco-Duocarmycin TM is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates. Synonyms: (S)-(1-(chloromethyl)-5-hydroxy-1H-benzo[e]indol-3(2H)-yl)(5,6,7-trimethoxy-1H-indol-2-yl)methanone. Grade: ≥95%. CAS No. 1142188-60-0. Molecular formula: C25H23ClN2O5. Mole weight: 466.91. | |
| Adolezesin | Adozelesin is an experimental antitumor drug of the duocarmycin class. It is the first of a class of DNA-sequence-selective alkylating agents. It binds to and alkylates DNA, resulting in a reduction of both cellular and simian virus 40 (SV40) DNA replication which ultimately reduces the rate of cancer growth. It has marginal efficacy in the treatment of metastatic breast cancer at the dosage and schedule used in clinic phase 1 and 2 trials. It was developed by Pharmacia and was terminated in clinic phase 2 trials. Uses: Adozelesin has marginal efficacy in the treatment of metastatic breast cancer. Synonyms: U73975; U-73975; U 73975; N-(2-((7bR,8aS)-7-methyl-4-oxo-1,2,4,5,8,8a-hexahydrocyclopropa[c]pyrrolo[3,2-e]indole-2-carbonyl)-1H-indol-5-yl)benzofuran-2-carboxamide. Grade: >98%. CAS No. 110314-48-2. Molecular formula: C30H22N4O4. Mole weight: 502.52. | |
| Pyrindamycin A | Pyrindamycin A is an antibiotic produced by the strain of Streptomyces spp. It inhibits DNA synthesis and has the activity against gram-positive and gram-negative bacteria. It has antitumor activity against murine leukemia, shows stronger cytotoxic activities towards murine and human tumor cell lines and especially towards doxorubicin-resistant cells, inhibits P388 and P388/ADR cells with the same IC50 of 3.9 μg/ml. Synonyms: Duocarmycin C2; Antibiotic DC 89A2; Benzo(1,2-b:4,3-b')dipyrrole-2-carboxylic acid, 8-(chloromethyl)-1,2,3,6,7,8-hexahydro-4-hydroxy-2-methyl-1-oxo-6-((5,6,7-trimethoxy-1H-indol-2-yl)carbonyl)-, methyl ester, (2R-trans)-; Methyl (2R,8S)-8-(chloromethyl)-4-hydroxy-2-methyl-1-oxo-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-1,2,3,6,7,8-hexahydropyrrolo[3,2-e]indole-2-carboxylate; Antibiotic SF 2582A. Grade: ≥95%. CAS No. 118292-36-7. Molecular formula: C26H26ClN3O8. Mole weight: 543.95. | |
| Seco-DUBA | seco-DUBA hydrochloride is a cell-permeable pro-drug that is cleaved into the active toxin (DUBA) in intracellular lysosomes by proteases, after internalization. The payload then alkylates the DNA, causing DNA damage and cell death. Synonyms: Seco-duocarmycin; (S)-N-(2-(9-chloro-1-ethyl-5-hydroxy-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)imidazo[1,2-a]pyridin-6-yl)-4-hydroxybenzamide; Benzamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-9-methyl-3H-benz[e]indol-3-yl]carbonyl]imidazo[1,2-a]pyridin-6-yl]-4-hydroxy-; N-[2-[[(1S)-1-(Chloromethyl)-1,2-dihydro-5-hydroxy-9-methyl-3H-benz[e]indol-3-yl]carbonyl]imidazo[1,2-a]pyridin-6-yl]-4-hydroxybenzamide. Grade: ≥95%. CAS No. 1227961-59-2. Molecular formula: C29H23ClN4O4. Mole weight: 526.97. | |
| Seco-DUBA | Seco-DUBA is a duocarmycin (DUBA) prodrug containing two hydroxyl groups, which can each be used for coupling to an antibody via a linker. Seco-DUBA can be used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1227961-59-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-132180A. | |
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