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| Product | Description | |
|---|---|---|
| EB 47 | EB 47. Group: Biochemicals. Grades: Purified. CAS No. 1190332-25-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| EB 47 | EB 47 is a potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). Poly(ADP-ribose) polymerases (PARPs) play a major role in cellular survival and maintenance of energy stores after genotoxic insult. Synonyms: 5'-Deoxy-5'-[4-[2-[(2,3-dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine; 4-[1-(6-Amino-9H-purin-9-yl)-1-deoxy-β-D-ribofuranuronoyl]-N-(2,3-dihydro-1-oxo-1H-isoindol-4-yl)-1-piperazineacetamide. CAS No. 366454-36-6. Molecular formula: C24H27N9O6. Mole weight: 537.53. |  |
| EB 47-d8 | Isotope labelled EB 47 is a potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). Poly(ADP-ribose) polymerases (PARPs) play a major role in cellular survival and maintenance of energy stores after genotoxic insult. Synonyms: 5'-Deoxy-5'-[4-[2-[(2,3-dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine-d8; 4-[1-(6-Amino-9H-purin-9-yl)-1-deoxy-β-D-ribofuranuronoyl]-N-(2,3-dihydro-1-oxo-1H-isoindol-4-yl)-1-piperazineacetamide-d8. Molecular formula: C24H19D8N9O6. Mole weight: 545.58. | |
| EB 47 dihydrochloride | EB 47 dihydrochloride is a PARP-1 inhibitor (IC50 = 45 nM) that reduces infarct volume in both a rat transient middle cerebral arterial occlusion model and a cardiac reperfusion model. Synonyms: EB 47 dihydrochloride; EB47 dihydrochloride; EB-47 dihydrochloride; 5'-Deoxy-5'-[4-[2-[(2,3-Dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 1190332-25-2. Molecular formula: C24H27N9O6.2HCl. Mole weight: 610.45. | |
| 7α,27-Dihydroxycholesterol | 7α,27-Dihydroxycholesterol is an oxysterol characterized by its oxidized side chains and is produced through the hydroxylation of 27-Hydroxycholesterol (27-OHC); it serves as a metabolite of interest in lipidomic analyses of various pathological conditions, including neurological diseases, Smith-Lemli-Opitz syndrome, obesity metabolic syndrome, and diabetes. Notably, levels of 7α,27-di-OHC decrease following lipopolysaccharide activation, and it also functions as a ligand for Epstein-Barr virus-induced gene 2 (EBI2). Additionally, 7α,27-di-OHC exists as a structural isomer of 7α,25-dihydroxycholesterol (7α25-OHC). Uses: Scientific research. Group: Signaling pathways. CAS No. 4725-24-0. Pack Sizes: 1 mg. Product ID: HY-W414548. |  |
| BGC 20-1531 hydrochloride | BGC 20-1531 hydrochloride is a potent and selective EP4 antagonist, which exhibits <50% inhibition at 47 ion channels, cell-surface transporters, enzymes, and nuclear receptors. It has high affinity and selective with Ki of 3 nM for EP4 antagonist. BGC 20-1531 antagonizes PGE2-induced cAMP accumulation in a dose-dependent manner in HEK293 EBNA. It also reverses PGE2-induced vasorelaxation with Kb of 15.85 nM in human middle cerebral and middle meningeal arterial rings. Synonyms: BGC20-1531 HCl; BGC20-1531 hydrochloride; BGC20-1531; BGC 20-1531; BGC-20-1531; BGC201531; BGC 201531; BGC-201531; PGN 1531; PGN-1531; PGN1531. Grades: ≥98%. CAS No. 1962928-26-2. Molecular formula: C26H24N2O6S·HCl. Mole weight: 529. | |
| Ebanol ® | Ebanol ®. CAS No. 67801-20-1. FEMA No. 4775. Kosher: Y. VIGON Item # 500884. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers. Synonyms: ebanol : 3- methyl-5-(2,2,3-trimethyl-3-cyclopentenyl) pent-4-en-2-ol : (Z)-3- methyl-5-(2,2,3-trimethyl-1-cyclopent-3-enyl)pent-4-en-2-ol : 3- methyl-5(2,2,3-trimethyl-3-cyclopenten-1-yl)-4-penten-2-ol : sandal pentenol : DRT : MATSUNOL 87pc : Givaudan : Ebanol |  America & Internationally |
| Ebrotidine | Ebrotidine(FI 3542), a competitive H2-receptor antagonist, has gastroprotective activity under the condition of gastric mucosal damage caused by some stress responses. IC50: 127.5 nM (Ki)[1]; 0.21mg/kg (ED50, histamine- stimulated acid secretion). It also. Uses: Ebrotidine(fi 3542) is a competitive h2-receptor antagonist and has gastroprotective activity under the condition of gastric mucosal damage caused by some stress responses. Synonyms: FI-3542; FI 3542; FI3542; Ebrotidine. Grades: 95%. CAS No. 100981-43-9. Molecular formula: C14H17BrN6O2S3. Mole weight: 477.43. | |
| Ebrotidine. | Ebrotidine. Group: Biochemicals. Alternative Names: [N (E) ] -N- [ [ [2- [ [ [2- [ (Aminoiminomethyl) amino] -4-thiazolyl] methyl] thio] ethyl] amino] methylene] -4-bromo Benzene sulfonamide; Ebrodin; FI 3542; Ulsanic. Grades: Highly Purified. CAS No. 100981-43-9. Pack Sizes: 50mg. Molecular Formula: C14H17BrN6O2S3, Molecular Weight: 477.42. US Biological Life Sciences. | Worldwide |
| PF-06873600 | Ebvaciclib, also known as PF-06873600, is an orally bioavailable, cyclin-dependent kinase (CDK) inhibitor, with potential antineoplastic activity. Upon administration, PF-06873600 selectively targets, binds to and inhibits the activity of CDKs. Inhibition of these kinases leads to cell cycle arrest, induction of apoptosis and inhibition of tumor cell proliferation. CDKs, ATP-dependent serine/threonine kinases that are important regulators of cell cycle progression and cellular proliferation, are frequently overexpressed in tumor cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Ebvaciclib; PF-06873600; PF 06873600; PF06873600. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2185857-97-8. Molecular formula: C20H27F2N5O4S. Mole weight: 471.52. Purity: >98%. IUPACName: Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-. Canonical SMILES: O=C1C(C(F)F)=CC2=CN=C(NC3CCN(S(=O)(C)=O)CC3)N=C2N1[C@H]4[C@](C)(O)CCC4. Product ID: ACM2185857978. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Primycin | Primycin is a macrolide antibiotic produced by Str. primycini. It is active against gram-positive bacteria, mycobacteria and protozoa. Synonyms: Ebrimycin; Primycin A1. CAS No. 47917-41-9. Molecular formula: C55H103N3O17. Mole weight: 1078.4. | |
| Tamoxifen | Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator ( SERM ) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells [1] [2] [3]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC 50 of 0.1 μM and 1.8 μM, respectively [5]. Tamoxifen activates autophagy and induces apoptosis [4]. Tamoxifen also can induce gene knockout of CreER transgenic mouse [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ICI 47699; (Z)-Tamoxifen; trans-Tamoxifen. CAS No. 10540-29-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-13757A. | |
| Tamoxifen (Standard) | Tamoxifen (Standard) is the analytical standard of Tamoxifen (HY-13757A). This product is intended for research and analytical applications. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator ( SERM ) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells [1] [2] [3]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC 50 of 0.1 μM and 1.8 μM, respectively [5]. Tamoxifen activates autophagy and induces apoptosis [4]. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ICI 47699(Standard); (Z)-Tamoxifen(Standard); trans-Tamoxifen (Standard). CAS No. 10540-29-1. Pack Sizes: 10 mg; 25 mg; 50 mg. Product ID: HY-13757AR. | |
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