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Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis. Uses: Scientific research. Group: Natural products. CAS No. 2424-92-2. Pack Sizes: 5 g; 10 g; 25 g; 100 g. Product ID: HY-W034595.
100g Pack Size. Group: Building Blocks, Organics. Formula: C20H42. CAS No. 112-95-8. Prepack ID 45515231-100g. Molecular Weight 282.54. See USA prepack pricing.
N-Eicosane
Environmental Standards. Alternative Names: Icosane. CAS No. 112-95-8. Molecular formula: C20H42. Mole weight: 282.5. Catalog: ACM112958-1.
20-(tert-Butoxy)-20-oxoicosanoic acid
20-(tert-Butoxy)-20-oxoicosanoic acid (CAS# 683239-16-9 ) is a useful research chemical. Synonyms: MolPort-027-853-795; ZX-RL000706; Eicosanedioic acid 1-tert-butyl ester; Eicosanedioic acid, 1-(1,1-dimethylethyl) ester; Eicosanedioic Acid Mono-Tert-Butyl Ester. Grades: ≥ 98 %. CAS No. 683239-16-9. Molecular formula: C24H46O4. Mole weight: 398.60.
Hydrolyzed Fumonisin B2
Hydrolyzed Fumonisin B2 is a metabolite of Fumonisin B2, a mycotoxin produced by mold associated with corn. Synonyms: Fumonisin AP2; Fumonisin HB2; Hydrolyzed Fumonisin B2; 3,?5,?14,?15-Eicosanetetrol, 2-amino-12,?16-dimethyl-, (2S,?3S,?5R,?12S,?14S,?15R,?16R)?-; (2S,3S,5R,12S,14S,15R,16R)-2-Amino-12,16-dimethyl-3,5,14,15-eicosanetetrol. Grades: ≥97%. CAS No. 147985-10-2. Molecular formula: C22H47NO4. Mole weight: 389.61.
12-Oxoleukotriene B4 in acetonitrile
12-oxo Leukotriene B4 in acetonitrile is a potent eicosanoid lipid mediators. Group: Biochemicals. Grades: Highly Purified. CAS No. 136696-10-1. Pack Sizes: 25ug, 50ug. Molecular Formula: C20H30O4, Molecular Weight: 334.45. US Biological Life Sciences.
Worldwide
15-epi-Prostacyclin Sodium Salt
15-epi-Prostacyclin Sodium Salt is a derivative of Prostacyclin Sodium Salt (P839060) which is an eicosanoid that prevents the formation of platelet plugs and is an effective vasodilator. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C20H31NaO5, Molecular Weight: 374.45. US Biological Life Sciences.
Worldwide
(±)17(18)-EpETE
The epoxygenase pathway is one of the three major branches of eicosanoid biosynthesis. Synonyms: (±)17,18-EEQ; (±)17,18-epoxy Eicosatetraenoic Acid; (5Z,8Z,11Z,14Z)-16-(3-ethyloxiran-2-yl)hexadeca-5,8,11,14-tetraenoic acid. Grades: ≥90%. Molecular formula: C20H30O3. Mole weight: 318.5.
1-Eicosanol is a natural compound with antioxidant activity isolated from Hypericum carinatum [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Arachidyl alcohol. CAS No. 629-96-9. Pack Sizes: 500 mg; 1 g. Product ID: HY-W004263.
1-Eicosanol
1-Eicosanol works as a non-ionic surfactant in cosmetics. Group: Biochemicals. Grades: Highly Purified. CAS No. 629-96-9. Pack Sizes: 250mg, 2.5g. Molecular Formula: C20H42O, Molecular Weight: 298.55. US Biological Life Sciences.
Worldwide
1-Eicosanol, 2-tetradecyl-
Use as dispersing agent, emulsifying agent. Use as lubricant. Use as intermediate in organic synthesis. Group: Non-ionic surfactants. Alternative Names: Tetradecyleicosanol;2-Tetradecyleicosanol. CAS No. 119691-49-5. Molecular formula: C34H70O. Mole weight: 494.92. Catalog: ACM119691495.
20-trifluoro Leukotriene B4
20-trifluoro Leukotriene B4 is an eicosanoid lipid mediator. Group: Biochemicals. Grades: Highly Purified. CAS No. 115178-97-7. Pack Sizes: 25ug, 50ug. Molecular Formula: C20H29F3O4, Molecular Weight: 390.44. US Biological Life Sciences.
Worldwide
2-Hexadecyl-1-eicosanol
2-Hexadecyl-1-eicosanol is used as a reagent to synthesize palmitan which is a new type of cosmetic raw material. 2-Hexadecyl-1-eicosanol works as a surfactant in cosmetics. Group: Biochemicals. Grades: Highly Purified. CAS No. 17658-63-8. Pack Sizes: 100mg, 1g. Molecular Formula: C36H74O, Molecular Weight: 522.97. US Biological Life Sciences.
Worldwide
Arachidic acid
Arachidonic acid (Icosanoic acid), an orally active long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant saturated fatty acids present in human tissue. Moreover, Arachidonic acid is an important mediator of inflammation [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Eicosanoic acid. CAS No. 506-30-9. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W004260.
Arachidic acid (Standard)
Arachidic acid (Standard) is the analytical standard of Arachidic acid. This product is intended for research and analytical applications. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Eicosanoic acid (Standard). CAS No. 506-30-9. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-W004260R.
Arachidonic acid
Arachidonic acid is an essential fatty acid and a precursor in the biosynthesis of thromboxanes, prostaglandins and leukotrienes. It is a transient, critical substrate for the biosynthesis of eicosanoid second messengers. It is an important cellular signaling mediator in a variety of biological processes, including smooth chemotaxis, muscle contraction, apoptosis, cell proliferation and differentiation. It exits in liver, brain, glandular organs, and depot fats of animals and a constituent of animal phosphatides. It could bind to the subunit of G protein and inhibit the activity of Ras GTPase-activating proteins (GAPs). It stimulates adhesion of MDA-MB-435 human metastatic cancer cells to extracellular matrix molecules. Synonyms: Arachidonate. Grades: 98 %. CAS No. 506-32-1. Molecular formula: C20H32O2. Mole weight: 304.47.
Arachidonic acid-[13C20]
Labelled Arachidonic acid. Arachidonic acid is an essential fatty acid and a precursor in the biosynthesis of thromboxanes, prostaglandins and leukotrienes. It is a transient, critical substrate for the biosynthesis of eicosanoid second messengers. It is an important cellular signaling mediator in a variety of biological processes, including smooth chemotaxis, muscle contraction, apoptosis, cell proliferation and differentiation. It exits in liver, brain, glandular organs, and depot fats of animals and a constituent of animal phosphatides. It could bind to the subunit of G protein and inhibit the activity of Ras GTPase-activating proteins (GAPs). It stimulates adhesion of MDA-MB-435 human metastatic cancer cells to extracellular matrix molecules. Grades: > 98%. Molecular formula: [13C]20H32O2. Mole weight: 324.32.
BM 567
Thromboxane A2 (TXA2) is a potent thrombogenic and vasoconstrictor eicosanoid. It has been reported as a causal factor in the onset of stroke and myocardial infarction. BM 567 is a dual acting antithrombogenic agent, which is acting as an inhibitor of thromboxane A2 (TXA2) synthase and an antagonist of the TP receptor. It also antagonizes the vascular smooth muscle TP receptor with an IC50 value of 1.1 nM. Synonyms: BM567; BM-567. Grades: ≥98%. CAS No. 284464-77-3. Molecular formula: C18H28N4O5S. Mole weight: 412.5.
Canniprene, an isoprenylated bibenzyl unique to Cannabis sativa , is a potent inhibitor of 5-lipoxygenase ( 5-LO ) activity ( IC 50 =0.4 μM) and cyclooxygenase/microsomal prostaglandin E2 synthase ( PGE 2 ; IC 50 =10 μM). Canniprene inhibits the production of inflammatory eicosanoids and affects the generation of prostaglandins [1]. Uses: Scientific research. Group: Natural products. CAS No. 70677-47-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N3535.
Capsorubin
Capsorubin. Group: Biochemicals. Alternative Names: (3S,3'S,5R,5'R)-3,3'-Dihydroxy-κ,κ-carotene-6,6'-dione; (1R,1R,4S,4S)-(all-E)-1,20-Bis(4-hydroxy-1,2,2-trimethylcyclopentyl)-4,8,13,17-tetramethyl-2,4,6,8,10,12,14,16,18-eicosanonaene-1,20-dione; Capsorubin; all-trans-Capsorubin. Grades: Highly Purified. CAS No. 470-38-2. Pack Sizes: 5mg. Molecular Formula: C40H56O4, Molecular Weight: 600.87. US Biological Life Sciences.
Worldwide
CAY10590
Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, liberating arachidonic acid for subsequent eicosanoid synthesis. There are three primary types of PLA2 exist: secretory (sPLA2), calcium-dependent cytosolic (cPLA2), and calcium-independent cytosolic (iPLA2). CAY10590 is a selective and potent inhibitor of sPLA2. It exhibits 95% inhibition (XI(50) = 0.003) of sPLA2 at 0.091 mole fraction without affecting the activities of cPLA2 or iPLA2. Synonyms: CAY 10590; CAY-10590. Grades: ≥98%. CAS No. 1101136-50-8. Molecular formula: C21H33NO3. Mole weight: 347.5.
Cyclooxygenase 1 from Human, Recombinant
COX-1 catalyzes the conversion of arachidonic acid to prostaglandin H2 (the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins). It is involved in the homeostatic role of eicosanoids and constitutively almost all animal tissues. Has an apparent KM of 8.3 μM for arachidonic acid. Group: Enzymes. Synonyms: COX-1; Constitutive cyclooxygenase; Prostaglandin H synthase 1; Prostaglandin endoperoxide synthase; EC 1.14.99.1; prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase. COX-1. Mole weight: ~70 kDa. Activity: >20,000 units/mg. Stability: > 6 months. Storage: -80°C (as supplied); avoid freeze/thaw cycles by aliquoting protein. Form: 80 mM Tris, pH 8.0, containing 0.1% polysorbate 20, 300 uM DDC, and 10% glycerol. Source: Sf21 cells. Species: Human. COX-1; Constitutive cyclooxygenase; Prostaglandin H synthase 1; Prostaglandin endoperoxide synthase; EC 1.14.99.1; prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase. Cat No: NATE-1237.
Dihomo-γ-Linolenic acid methyl ester
Dihomo-γ-Linolenic acid is an n-6 polyunsaturated fatty acid that is mainly metabolized to an anti-inflammatory eicosanoid, prostaglandin (PG) E1, via the cyclooxygenase (COX) pathway. Anti-inflammatory and anti-proliferative effects [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 21061-10-9. Pack Sizes: 5 mg (312 mM * 50 μL in Ethanol); 10 mg (312 mM * 100 μL in Ethanol). Product ID: HY-116015.
Eicosanoic-17,17,18,18-d4acid
Heterocyclic Organic Compound. CAS No. 1219803-69-6. Molecular formula: 316.56. Purity: 98 atom % D. Catalog: ACM1219803696.
Icosanamide, a derivative of fatty acid, displays promise as a therapeutic agent for diverse inflammatory ailments. With its impressive anti-inflammatory attributes, the compound has garnered attention for handling autoimmune diseases and treating conditions such as rheumatoid arthritis. Its efficacy is well-documented in several clinical studies. Synonyms: Eicosanamide; Arachamide. CAS No. 51360-63-5. Molecular formula: C20H41NO. Mole weight: 311.554.
Kahweol eicosanate
Heterocyclic Organic Compound. Alternative Names: KAHWEOL EICOSANATE. CAS No. 108214-32-0. Molecular formula: C40H64O4. Mole weight: 608.93. Catalog: ACM108214320.
Ketorolac
Ketorolac, a non-selective COX inhibitor, is a non-steroidal anti-inflammatory drug. It shows inhibition of eicosanoid formation in HEL cells (COX-1) and LPS-stimulated Mono Mac 6 cells (COX-2), but does not significantly inhibit NO accumulation in supernatants of LPS-stimulated RAW 264.7 cells. It significantly inhibits thymidine incorporation of human osteoblasts (hOBs) upon 24 hours treatment in a dose-dependent manner, and inhibits proliferation and arrests cell cycle at G0/G1 phase in hOBs. Uses: Cyclooxygenase inhibitors. Synonyms: Acular LS; RS37619; RS 37619; RS-37619; Sprix; Toradol. Grades: >98%. CAS No. 74103-06-3. Molecular formula: C15H13NO3. Mole weight: 255.27.
KT109
KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC 50 of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGL&alpha. KT109 shows inhibitory activity against PLA2G7 (IC 50 =1 μM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-arachidonoylglycerol (2-AG), arachidonic acid and eicosanoids in mouse peritoneal macrophages [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1402612-55-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18540.
Leukotriene C4
Leukotriene C4 is a eicosanoid lipid mediator and produced by immune cells during type 2 inflammation. Leukotriene C4 can mediate inflammation,allergy, bronchoconstriction, and vascular leakage [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 72025-60-6. Pack Sizes: 25 μg (159.8 μM * 250 μL in Ethanol). Product ID: HY-113446.
Lipoxin A4
Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties [1]. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways [2]. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC 50 value of 25.74 nM [3]. Uses: Scientific research. Group: Natural products. Alternative Names: LXA4. CAS No. 89663-86-5. Pack Sizes: 25 μg (283.71 μM * 250 μL in Ethanol). Product ID: HY-113509.
Methyl arachidate
Methyl arachidate is a natural compound which can be isolated from Lepidium meyenii, Begonia heracleifolia, etc. Synonyms: Methyl eicosanoate; Arachidic acid methyl ester; Eicosanoic acid, methyl ester. Grades: 98%. CAS No. 1120-28-1. Molecular formula: C21H42O2. Mole weight: 326.56.
Methyl arachidate
Methyl arachidate (Methyl eicosanoate), a natural compound, is a leukotriene A4 hydrolase (LTA4H) inhibitor [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Methyl icosanoate. CAS No. 1120-28-1. Pack Sizes: 500 mg. Product ID: HY-W004291.
Methyl eicosanoate
Heterocyclic Organic CompoundFatty Acids and Ester Homologs. Alternative Names: Eicosanoic acid methyl ester. CAS No. 1120-28-1. Molecular formula: C21H42O2. Mole weight: 326.57. Appearance: Solid. Purity: 99%+. Catalog: ACM1120281.
Native Crotalus Phospholipase A2
Phospholipases A2 (PLA2s) EC 3.1.1.4 are enzymes that release fatty acids from the second carbon group of glycerol. This particular phospholipase specifically recognizes the sn-2 acyl bond of phospholipids and catalytically hydrolyzes the bond releasing arachidonic acid and lysophospholipids. Upon downstream modification by cyclooxygenases, arachidonic acid is modified into active compounds called eicosanoids. Eicosanoids include prostaglandins and leukotrienes, which are categorized as anti-inflammatory and inflammatory mediators. Phospholipase a2 is a member of the class of heat-stable, calcium-dependent enzymes catalyzing the hydrolysis of the 2-acyl bond of 3-n-phosphoglycerides. a chromatographically purified, dialyzed, lyophilized powder. Group: Enzymes. Synonyms: EC 3.1.1.4; Phospholipases A2; PLA2s. Enzyme Commission Number: EC 3.1.1.4. CAS No. 9001-86-9. Purity: chromatographically purified, dialyzed. PLA2. Mole weight: 30 kDa (Wells 1969). Activity: > 200 units per mg dry weight. Stability: The enzyme is stable at 90°C and pH 3.0 for at least five minutes. (Uthe 1971; Saito 1962). Storage: Store at 2-8°C. Form: lyophilized powder. Source: Crotalus adamanteus Venom. Species: Crotalus. EC 3.1.1.4; Phospholipases A2; PLA2s. Cat No: NATE-0591.
Native Sheep Cyclooxygenase 1
COX-1 catalyzes the conversion of arachidonic acid to prostaglandin H2 (the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins). It is involved in the homeostatic role of eicosanoids and constitutively almost all animal tissues. Has an apparent KM of 8.3 μM for arachidonic acid. Group: Enzymes. Synonyms: COX-1; Constitutive cyclooxygenase; Prostaglandin H synthase 1; Prostaglandin endoperoxide synthase; EC 1.14.99.1; prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase. Enzyme Commission Number: EC 1.14.99.1. CAS No. 9055-65-6. Purity: > 95% (SDS-PAGE). COX-1. Mole weight: dimer subunit mol wt 70 kDa. Activity: > 40,000 units/mg protein. Storage: -70°C. Form: aqueous solution. Solution in 80 mM Tris-HCl, pH 8, with 0.1% TWEEN 20 and 300 μM diethyldithiocarbamate. Source: Sheep. COX-1; Constitutive cyclooxygenase; Prostaglandin H synthase 1; Prostaglandin endoperoxide synthase; EC 1.14.99.1; prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase. Cat No: NATE-0149.
Pranoprofen
Pranoprofen is a non-steroidal anti-inflammatory agent ( NSAID ) for the research of keratitis or other ophthalmology diseases. Pranoprofen inhibit COX-1 and COX-2 enzymes, thus blocking arachidonic acid converted to eicosanoids and reducing prostaglandins synthesis [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 52549-17-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-B0336.
Prostaglandin D2
Prostaglandin D2 (PGD2) is the major eicosanoid product found in mast cells and brain. It has been shown to induce inflammation such as allergic asthma. Synonyms: PGD2; 11-Dehydroprostaglandin F2-alpha; (Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid. Grades: ≥95%. CAS No. 41598-07-6. Molecular formula: C20H32O5. Mole weight: 352.5.
Resveratrol
Potent phenolic antioxidant found in grapes and red wine. Eicosanoid synthesis and platelet aggregation inhibitor. Estrogen receptor agonist. Chemopreventive. Specific inhibitor of cyclooxygenase-1 (COX-1). Anti-inflammatory. Ribonucleotide reductase and DNA synthesis. Arrests cell cycle at S/G2 phase. Anticancer and antiproliferative compound. Apoptosis inducer. Protein kinase D inhibitor. Does not inhibit PKC. Autophagy inducer. Potent SIRT1 (sirtuin 1) activator. Neuroprotective. Adipogenesis inhibitor. PGC-1alpha activator. Sonic hedgehog (Shh) signaling pathway modulator. Gli1 mRNA expression inhibitor. Downregulates Gli transcriptional activity. Cardioprotective. Anti-diabetic. Senescence modulator. Extends lifespan. Group: Biochemicals. Alternative Names: 3,4,5-Trihydroxy-trans-stilbene; 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol. Grades: Highly Purified. CAS No. 501-36-0. Pack Sizes: 25g, 50g, 100g, 250g, 500g. Molecular Formula: C14H12O3, Molecular Weight: 228.24. US Biological Life Sciences.
Worldwide
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