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Product | Description | |
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4-Bromo-3-hydroxybenzoic Acid Quick inquiry Where to buy Suppliers range | 4-Bromo-3-hydroxybenzoic acid is a potent inhibitor of the enzyme histidine decarboxylase with resultant inhibition of histamine formation in mammals. Synonyms: 4-bromo-3-hydroxybenzoic acid; 4-bromo-3-hydroxybenzoic acid. Grades: > 98 %. CAS No. 14348-38-0. Molecular formula: C7H5BrO3. Mole weight: 217.02. | |
5-Bromo-4-chloro-3-indolyl b-D-mannopyranoside Quick inquiry Where to buy Suppliers range | 5-Bromo-4-chloro-3-indolyl b-D-mannopyranoside is a compound widely used in the biomedical industry as an artificial chromogenic substrate. It is primarily employed in the detection and visualization of β-D-glucosidase enzyme activity. This compound finds applications in various biochemical assays, including determination of bacterial and mammalian β-D-glucosidase levels, providing valuable insights into drug discovery and disease research. Synonyms: X-Mannose. CAS No. 129787-67-3. Molecular formula: C14H15BrClNO6. Mole weight: 408.63. | |
5-Hydroxymethylcytidine Quick inquiry Where to buy Suppliers range | 5-Hydroxymethylcytosine is a DNA pyrimidine nitrogen base. It is formed from the DNA base cytosine by adding a methyl group and then a hydroxy group. It is important in epigenetics, because the hydroxymethyl group on the cytosine can possibly switch a gene on and off. It was first seen in bacteriophages in 1952.[1][2] However, in 2009 it was found to be abundant in human and mouse brains,[3] as well as in embryonic stem cells.[4] In mammals, it can be generated by oxidation of 5-methylcytosine, a reaction mediated by the Tet family of enzymes. 5-Hydroxymethylcytidine is a product in DNA hydroxymethylation. The concentrations of 5-Hydroxymethylcytidine in the brain were used to study Alzheimers disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 19235-17-7. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
6-Chloro-5-(2,3-dichlorophenoxy)-2-methylthio-benzimidazole (Triclabendazole) Quick inquiry Where to buy Suppliers range | Triclabendazole is a member of the benzimidazole family of anthelmintics. It is effective against F. hepatica helminths that cause fascioliasis, reducing secreted protease enzyme activities that are critical for the invasion, migration, nutrition, and survival of the parasite.1 In yeast and mammalian cells, triclabendazole was shown to inhibit adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway and to prevent apoptosis induced by the Parkinsons disease-related protein α-synuclein, demonstrating a protective role during various cellular stresses.2,3. Group: Biochemicals. Alternative Names: 5-Chloro-6- (2, 3-dichlorophenoxy) -2- methyl thiobenzimidazole; CGA-89317, egaten; Fasinex; Triclabendazole. Grades: Highly Purified. CAS No. 68786-66-3. Pack Sizes: 25g, 50g, 100g. Molecular Formula: C14H9Cl3N2OS, Molecular Weight: 359.66. US Biological Life Sciences. | Worldwide |
7, 12-Dimethylbenz [a]anthracene Quick inquiry Where to buy Suppliers range | A highly potent carcinogen that is activated by microsomal enzymes to a diol epoxide metabolite that binds covalently to DNA in mammalian cells, leading ultimately to tumor induction. Group: Biochemicals. Grades: Highly Purified. CAS No. 57-97-6. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
8R-Brassicasterol Quick inquiry Where to buy Suppliers range | 8R-Brassicasterol is a by-product in the synthesis of Brassicasterol (B676850). Brassicasterol is a phytosterol found in canola oil, rapeseed oil, marine algae and shellfish. This compound has been shown to inhibit sterol Δ24-reductase, an enzyme involved in the mammalian cholesterol biosynthesis pathway. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C28H46O. US Biological Life Sciences. | Worldwide |
ABTS Chromophore Diammonium Salt Quick inquiry Where to buy Suppliers range | ABTS Chromophore Diammonium Salt can inhibit catalase, a mammalian antioxidant enzyme which degrades hydrogen peroxide into water and oxygen species. Synonyms: 2,2'-(1,2-Hydrazinediylidene)bis[3-ethyl-2,3-dihydro-6-benzothiazolesulfonic Acid Ammonium Salt (1:2); 2,2'-Azinobis[3-ethyl-2,3-dihydro-6-benzothiazolesulfonic Acid Diammonium Salt; 3-Ethyl-2-oxo-6-Benzothiazolinesulfonic Acid Azine Diammonium Salt; 2,2'-Azino-bis-(3-ethyl-benzthiazoline-6-sulfonate) Diammonium Salt; 2,2'-Azinobis(3-ethylbenzothiazoline-6-sulfonic acid) Diammonium Salt; ABTS Diammonium Salt; Diammonium 2,2'-Azinobis(3-ethyl-6-benzothiazolinesulfonate); Diammonium 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonate). Grades: ≥98%. CAS No. 30931-67-0. Molecular formula: C18H24N6O6S4. Mole weight: 548.68. | |
Acidic Mammalian Chitinase Inhibitor, Bisdionin F Quick inquiry Where to buy Suppliers range | A cell-permeable, competitive Acidic Mammalian Chitinase (AMCase) Inhibitor (IC50=0.92uM and Ki=0.42uM for hAMCase, and IC50=2.2uM for mAMCase, in vitro) that demonstrates 20-fold selectivity for hAMCase over hCHIT1. It is shown to decrease chitinase enzymatic activity (5mg/kg, i.p.) in the lungs of control PBS- and OVA-challenged mice. Furthermore, it attenuates lung chitinase activity, reduces eosinophil influx, and improves ventilatory function, in vivo, in a murine model of allergic inflammation. It also causes neutrophilia in the lungs of OVA-challenged mice. Group: Biochemicals. Alternative Names: AMCase Inhibitor, 3,7-dimethyl-1-(3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)propyl)-1H-purine-2,6(3H,7H)-dione. Grades: Highly Purified. CAS No. 917877-86-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
AMPK Signaling Agonist, F17 (4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide) Quick inquiry Where to buy Suppliers range | A cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~0.1uM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-a1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25uM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C. Group: Biochemicals. Grades: Highly Purified. CAS No. 280112-24-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Brassicasterol-(2,2',3,4,4',6-D6) Quick inquiry Where to buy Suppliers range | Brassicasterol-(2,2',3,4,4',6-D6) is derived from Brassicasterol (B676850), which is a phytosterol found in canola oil, rapeseed oil, marine algae and shellfish. This compound has been shown to inhibit sterol Δ24-reductase, an enzyme involved in the mammalian cholesterol biosynthesis pathway. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C28H40D6O, Molecular Weight: 404.7. US Biological Life Sciences. | Worldwide |
CAY10594 Quick inquiry Where to buy Suppliers range | Phospholipase D (PLD) is an enzyme which cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. There are two mammalian isoforms of PLD, which are PLD1 and PLD2. CAY10594 is a potent phospholipase D2 inhibitor (PLD2), which also prevents the invasive migration of breast cancer cells. It ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis. Synonyms: CAY 10594; CAY-10594. Grades: ≥98%. CAS No. 1130067-34-3. Molecular formula: C26H28N4O2. Mole weight: 428.5. | |
CB30865 Quick inquiry Where to buy Suppliers range | CB30865 is a highly potent cytotoxic agent. The compound inhibits isolated mammalian thymidylate synthase (TS), but this inhibition is insufficient to account for its cellular toxicity. Thymidylate synthase (TS) is a critical enzyme in the de novo synthesis of thymidylate (dTTP) and has long been recognized as a target for chemotherapeutic intervention. Synonyms: CB-30865; CB 30865; CB30865; ZM 242421; ZM242421; ZM-242421. Grades: >98%. CAS No. 206275-15-2. Molecular formula: C26H22BrN5O2. Mole weight: 516.39. | |
Conoidin A Quick inquiry Where to buy Suppliers range | Peroxiredoxins are a ubiquitous family of antioxidant enzymes that also control cytokine-induced peroxide levels and thereby mediate signal transduction in mammalian cells. Conoidin A inactivates peroxiredoxins by covalently binding to the catalytic cysteine on the enzyme. It has been shown to inhibit peroxiredoxin II (IC50 = 23 μM) in the parasite T. gondii and peroxiredoxin I in the hookworm A. ceylanicum. Synonyms: 2,3-Bis(bromomethyl)quinoxaline 1,4-dioxide. Grades: ≥98%. CAS No. 18080-67-6. Molecular formula: C10H8Br2N2O2. Mole weight: 348. | |
DDMS Quick inquiry Where to buy Suppliers range | DDMS is a mechanism-based irreversible inhibitor with a 10-fold selectivity for CYP4A2 enzymes, which are mainly synthesized into 20-hete in mammalian kidneys. Synonyms: Dibromo-dodecenyl-methylsulfimide; 12,12-Dibromo-N-(methylsulfonyl)-11-dodecenamide. Grades: ≥98%. CAS No. 206052-03-1. Molecular formula: C13H23Br2NO3S. Mole weight: 433.2. | |
D-Glutamine tert-Butyl Ester Hydrochloride Quick inquiry Where to buy Suppliers range | D-Glutamine tert-Butyl Ester Hydrochloride is a protected form of D-Glutamine. D-Glutamine is an unnatural isomer of L-Glutamine that is present in human plasma an is a source of liberated ammonia. D-Glutamine can be synthesized by enzymatic means or can be found in cheeses, wine and vinegars as well. It is often used to determine the activity of Glutamine synthetase, an enzyme that is commonly found in the mammalian liver and brain that controls the use of nitrogen in cells. Group: Biochemicals. Alternative Names: D-Glutamine 1,1-Dimethylethyl Ester Hydrochloride; (R)-2-Amino-4-carbamoylbutyric Acid tert-Butyl Ester Hydrochloride. Grades: Highly Purified. CAS No. 422324-35-4. Pack Sizes: 250mg, 500mg, 1g. Molecular Formula: C?H??ClN?O?, Molecular Weight: 238.71. US Biological Life Sciences. | Worldwide |
Genistein Quick inquiry Where to buy Suppliers range | Cell-permeable, reversible, substrate competitive tyrosine kinase inhibitor (including EGFR phosphorylation), implicated in almost all cell growth and proliferation signal cascades. Inhibitor of mammalian DNA topoisomerase II. Anticancer agent, inducing cell cycle arrest and apoptosis. Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis. Binds estrogen receptor beta. Can increase the rate of growth of some ER expressing breast cancers. Potent alpha-glucosidase inhibitor. Anthelmintic. Anti-diabetic. Activates nuclear receptors, oestrogen receptors and peroxisome proliferator-activated receptors (all PPAR isoforms) and it inhibits various enzyme activities. Inhibitor of GLUT4-mediated glucose uptake in 3T3-L1 adipocytes. Stimulator of autophagy vacuolization. Antioxidant. TRAIL sensitizer. Acts as an agonist at the GPR30 receptor. DNA methyltransferase inhibitor. Genistein exhibits synergistic antibacterial effects on MRSA. Group: Biochemicals. Alternative Names: NSC 36586; Baichanin A; Differenol A; 4',5,7-Trihydroxyisoflavone; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. Grades: Highly Purified. CAS No. 446-72-0. Pack Sizes: 10mg, 50mg, 250mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
Glucosylceramide (Soy) Quick inquiry Where to buy Suppliers range | Glucosylceramide is synthesised enzymatically, by the glucosylceramide synthase-catalysed with the addition of a glucose residue to ceramide. They are present in neuronal and non-neuronal mammalian tissues and are found at low quantities in a large number of plant species, where they comprise 5-30% of total lipids in the plant plasma membrane, and in fungi. Synonyms: Cerebroside (Soy); GlcCer(d18:2/16:0). Grades: >99%. CAS No. 497155-61-0. Molecular formula: C40H75NO9. Mole weight: 714.03. | |
L-Aspartic Acid, non-animal Quick inquiry Where to buy Suppliers range | Aspartic acid (abbreviated as Asp or D; encoded by the codons [GAU and GAC]), also known as aspartate, is an α-amino acid that is used in the biosynthesis of proteins.[3] Similar to all other amino acids it contains an amino group and a carboxylic acid. Its α-amino group is in the protonated -NH+3 form under physiological conditions, while its α-carboxylic acid group is deprotonated ?COO? under physiological conditions. Aspartic acid has an acidic side chain (CH2COOH) which reacts with other amino acids, enzymes and proteins in the body. Under physiological conditions (pH 7.4) in proteins the side chain usually occurs as the negatively charged aspartate form, ?COO?. It is a non-essential amino acid in humans, meaning the body can synthesize it as needed.D-Aspartate is one of two D-amino acids commonly found in mammals. In proteins aspartate sidechains are often hydrogen bonded, often as asx turns or asx motifs, which often occur at the N-termini of alpha helices. Asp's L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. Asp (and glutamic acid) is classified as acidic, with a pKa of 3.9, however in a peptide this is highly dependent on the local environment (as with all amino acids), and could be as high as 14. Asp is pervasive in biosynthesis. Group: Biochemicals. Alternative Names: (S)-(+)-Aminosuccinic acid; (S)-Aminobutanedioic acid. Grades: Cell Culture Grade. CAS No. 56-84-8. Pack Sizes: 100g, 500g, 1Kg, 2.5Kg, 10Kg. Molecular Formula: C4H7NO4, Molecular Weight: 133.1. US Biological Life Sciences. | Worldwide |
L-Fucose-1-phosphate disodium salt Quick inquiry Where to buy Suppliers range | L-Fucose-1-phosphate disodium salt, a pivotal constituent in biomedical investigation, stands as a fundamental substrate for diverse enzymatic activities implicated in myriad biological phenomena. Its indispensability arises from its pivotal involvement in comprehending and scrutinizing the intricate metabolic pathways of L-fucose, an omnipresent saccharide within mammalian cellular matrices. Synonyms: 6-Deoxy-L-galactose-1-phosphate disodium salt. CAS No. 374726-44-0. Molecular formula: C6H11Na2O8P. Mole weight: 288.1. | |
Nitisinone Quick inquiry Where to buy Suppliers range | Nitisinone is a herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is used in treatment of inherited tyrosinemia type I. Group: Biochemicals. Alternative Names: 2-[2-Nitro-4- (trifluoromethyl) benzoyl]-. Grades: Highly Purified. CAS No. 104206-65-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Nitisinone-13C6 Quick inquiry Where to buy Suppliers range | Labeled Nitisinone. Nitisinone is a herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is used in treatment of inherited tyrosinemia type I. Group: Biochemicals. Alternative Names: 2-[2-Nitro-4- (trifluoromethyl) benzoyl]-. Grades: Highly Purified. CAS No. 1246815-63-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Penicillin G, Sodium Salt USP Quick inquiry Where to buy Suppliers range | Penicillin G is a broad based antibiotic used in mammalian cell culture. Penicillin G blocks the formation of bacterial cell walls, rendering bacteria unable to multiply and spread. The spectrum of activity of Penicillin G includes many aerobic and anaerobic gram-positive organisms. Aerobes susceptible to Penicillin G include most beta-hemolytic streptococci, beta-lactamase-negative staphylococci, Actinomyces species, some Bacillus anthracis, Corynebacterium species, and Erysipelothrix rhusiopathiae. Most species of anaerobes, including Clostridium species, but excluding beta-lactamase-producing Bacteroides species, are also susceptible to Penicillin G. Penicillin G is easily inactivated by beta-lactamases and has little efficacy against organisms that can produce these enzymes. In addition, Penicillin G is ineffective against those bacteria that are resistant by other mechanisms, such as having a relatively impermeable cell wall. Therefore, Penicillin G has little activity against man Group: Biochemicals. Alternative Names: (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(2-phenylacetyl)amino]- 4-Thia-1-azabicyclo[3. 2. 0]heptane-2-carboxylic Acid Sodium; 3, 3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3. 2. 0]heptane-2-carboxylic Acid Monosodium Salt; (2S, 5R, 6R)-3, 3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3. 2. 0]heptane-2-carboxylic Acid Monosodium Salt; American Penicillin; Benzylpenicillin Sodium; Benzylpenicillin Sodium Salt; Benzylpenicillinic Acid Sodium Salt; Crystapen; Ethacillin; Monocillin; Monosodium Benzylpenicillin; Mycofarm; Nalpen G; Nobak; Novocillin; Pen-A-Brasive; Penicillin G Sodium; Penilaryn; Sodium 6- (Phenylacetamido) penicillanate; Sodium Benzylpenicillin; Sodium Benzylpenicillin G; Sodium Benzylpenicillinate. Grades: USP. CAS No. 69-57-8. Pack Sizes: 50g, 100g, 500g, 1Kg. Molecular Formula: C16H17N2O4NaS, Molecular Weight: 356.37. US Biological Life Sciences. | Worldwide |
Pyrroloquinoline quinone disodium salt Quick inquiry Where to buy Suppliers range | The disodium salt form of Pyrroloquinoline quinone which is a cofactor related to the enzyme-catalyzed redox reactions glucose and methanol dehydrogenase. Pyrroloquinoline quinone disodium salt is isolated from cultures of methylotropic bacteria and tissues of mammals. Nutritional supplement in health care products. Uses: Ingredient of health care products. Synonyms: Methoxatin disodium salt; Methoxatin Disodium; PQQ; Disodium 4,5-dihydro-4,5-dioxo-1H-pyrrolo(2,3-f)quinoline-2,7,9-tricarboxylate. Grades: 95%. CAS No. 122628-50-6. Molecular formula: C14H4N2Na2O8. Mole weight: 374.17. | |
SB 706375 Quick inquiry Where to buy Suppliers range | SB 706375 is a high affinity and non-peptide antagonist of the mammalian urotensin-II (UT) receptor displaying ≥100-fold selectivity for the human UT receptor over 86 different receptors, ion channels, enzymes, transporters and nuclear hormones. SB 706375 also inhibits binding of radiolabeled urotensin to endogenous human UT receptors (Ki = 5.4 nM in a whole-cell binding assay). Synonyms: SB-706375; SB 706375; SB706375. 2-Bromo-4, 5-dimethoxy-N-[3-[[ (3R) -1-methyl-3-pyrrolidinyl]oxy]-4- (trifluoromethyl) phenyl]benzenesulfonamide. Grades: ≥98% by HPLC. CAS No. 733734-61-7. Molecular formula: C20H22BrF3N2O5S. Mole weight: 539.36. | |
Trigonelline Hydrochloride Quick inquiry Where to buy Suppliers range | Trigonelline is a pyridine alkaloid found in various edible seeds and legumes, including coffee. It is a zwitterion formed by the methylation of the nitrogen atom of niacin (vitamin B3; nicotinic acid) and, as a product of niacin metabolism, is excreted in urine of mammals.1 Trigonelline has been used to reduce blood glucose levels and to inhibit PPARγ expression in rat models of diabetes.2,3 It is also reported to inhibit the migration of hepatocarcinoma cells and render them more susceptible to apoptosis by reducing Raf/ERK/Nrf2 protein levels and activities of anti-oxidative enzymes further downstream, such as SOD, catalase, and glutathione peroxidase.4,5. Group: Biochemicals. Alternative Names: 1-Methylpyridinium-3-carboxylate hydrochloride; N-Methylnicotinic acid betaine hydrochloride. Grades: Plant Grade. CAS No. 6138-41-6. Pack Sizes: 1g, 5g, 10g. Molecular Formula: C7H8ClNO2, Molecular Weight: 173.6. US Biological Life Sciences. | Worldwide |