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Product | Description | |
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10,17 β-Dihydroxy-estra-1,4-dien-3-one Quick inquiry Where to buy Suppliers range | 10,17 β-Dihydroxy-estra-1,4-dien-3-one is a prodrug that can be converted to the main human estrogen, 17 β-estradiol, in the brain and not elsewhere in the body due to an enzyme expressed only in the brain. It provides positive estrogenic effects on the brain and relieve symptoms in patients with a broad range of central nervous system diseases without side effects in other tissues. Group: Biochemicals. Grades: Highly Purified. CAS No. 549-02-0. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C18H24O3, Molecular Weight: 288.38. US Biological Life Sciences. | Worldwide |
1-(1-Methyl-1-phenylethyl)piperidine Quick inquiry Where to buy Suppliers range | 2-Phenyl-2-(1-piperidinyl)propane is an analog of phencyclidine that acts as a mechanism-based inactivator of human cytochrome P450 (CYP) 2B6 (Ki = 5.6 μM; IC50 = 5.1 μM). A selective inactivator of CYP2B6. Uses: Enzyme inhibitor. a selective inactivator of cyp2b6. Synonyms: 1-(2-phenylpropan-2-yl)piperidine; 1-(2-phenylpropan-2-yl)piperidine. Grades: ≥ 95 %. CAS No. 92321-29-4. Molecular formula: C14H21N. Mole weight: 203.32. | |
1-(2',3'-Dideoxy-2',3'-didehydro-2'-fluoro-5'-O-trityl-b-L-ribofuranosyl)-uracil Quick inquiry Where to buy Suppliers range | 1-(2',3'-Dideoxy-2',3'-didehydro-2'-fluoro-5'-O-trityl-b-L-ribofuranosyl)-uracil, a pharmacological compound renowned for its potent antiviral properties, is extensively employed as a therapeutic agent in the management of human immunodeficiency virus (HIV) infections. Its mechanism of action entails the inhibition of reverse transcriptase, a pivotal enzyme indispensable for viral replication. Synonyms: 1-(2',3'-Dideoxy-2',3'-didehydro-2'-fluoro-5'-O-trityl-β-L-ribofuranosyl)-uracil. Molecular formula: C28H23FN2O4. Mole weight: 470.49. | |
1,3-PBIT dihydrobromide Quick inquiry Where to buy Suppliers range | 1,3-PBIT is a potent inhibitor of iNOS with a Ki of 47 nM compared to Ki values for eNOS and nNOS are 9 and 0.25 μM, respectively, for the purified human enzymes. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability. 3-PBIT, also known as S,S'-(1,3-Phenylenebis(1,2-ethanediyl))bisisothiourea, is a potent and selective iNOS inhibitor. Synonyms: 2-[3- (2-carbamimidoylsulfanylethyl) phenyl]ethyl carbamimidothioate dihydrobromide. Grades: ≥98%. CAS No. 200716-66-1. Molecular formula: C12H18N4S2·2HBr. Mole weight: 444.2. | |
1-[(5E)-3-O-[(Bis-diisopropylamino)(2-cyanoethoxy)phos-phino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-methyl-β-D-ribo-hex-5-enofuranosyl]uracil Quick inquiry Where to buy Suppliers range | 1-[(5E)-3-O-[(Bis-diisopropylamino)(2-cyanoethoxy)phos-phino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-methyl-β-D-ribo-hex-5-enofuranosyl]uracil, a potent agent for the treatment of human immunodeficiency virus (HIV) infections, functions as a viral replication inhibitor by suppressing the reverse transcriptase enzyme. Its intricate molecular structure reflects the sophisticated nature of modern pharmaceuticals, which require cutting-edge research and development to ultimately undo the feats of viruses and other elusive adversaries. Synonyms: 2,4(1H,3H)-Pyrimidinedione, 1-[(5E)-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-methyl-β-D-ribo-hex-5-enofuranosyl]-. Grades: ≥95%. CAS No. 2361324-80-1. Molecular formula: C24H40N4O9P2. Mole weight: 590.54. | |
1-Methyl-D-tryptophan Quick inquiry Where to buy Suppliers range | 1-Methyl-D-tryptophan is used in biological studies to determine the effect of IDO2 enzyme (indoleamine-(2,3)-dioxygenase) activity and IDO2-mediated arrest of human T cell proliferation. It reverses IDO-mediated immune suppression. Group: Biochemicals. Grades: Highly Purified. CAS No. 110117-83-4. Pack Sizes: 250mg, 500mg. Molecular Formula: C12H14N2O2. US Biological Life Sciences. | Worldwide |
20(S)-Ginsenoside F1 Quick inquiry Where to buy Suppliers range | Ginsenoside F1 is a bioactive metabolite of the ginsenoside component of Panax ginseng with the ability to inhibit human cytochrome P450 enzymes. This has application in anti-cancer therapeutics as well as protective liver effects. Group: Biochemicals. Grades: Highly Purified. CAS No. 53963-43-2. Pack Sizes: 10mg, 25 mg. Molecular Formula: C36H62O9. US Biological Life Sciences. | Worldwide |
2',3'-Dideoxyinosine-5'-monophosphate sodium salt Quick inquiry Where to buy Suppliers range | 2',3'-Dideoxyinosine-5'-monophosphate sodium salt, a remarkable pharmaceutical compound, emerges as a pivotal player in the battle against human immunodeficiency virus (HIV) infection. Exhibiting its prowess as an antiviral agent, this compound effectively thwarts the replication of the virus by inhibiting the reverse transcriptase enzyme. Synonyms: Didanosine 5'-monophosphate sodium salt. Molecular formula: C10H11N4O6P·Na2. Mole weight: 360.17. | |
2,4-Dinitrophenyl 2-Deoxy-2-fluoro-β-D-galactoside Quick inquiry Where to buy Suppliers range | Fluorinated and deoxygenated glycosides as mechanistic probes of Escherichia coli (lacZ) β-galactosidase. By use of the slow substrate 2,4-dinitrophenyl-2-deoxy-2-fluoro-β-D-galactopyranoside, a glycosyl enzyme intermediate has been trapped on the enzyme. Glu-268 was identified as the catalytic nucleophile of human lysosomal β-galactosidase precursor. Synonyms: 2,4-Dinitrophenyl 2-Deoxy-2-fluoro-β-D-galactopyranoside. Grades: 98%. CAS No. 143716-62-5. Molecular formula: C12H13FN2O9. Mole weight: 348.24. | |
2-(4-Thiazolyl)benzimidazole Quick inquiry Where to buy Suppliers range | 2-(4-Thiazolyl)benzimidazole. Uses: Systemic fungicide used for diseases of fruits and vegetables and for control of Dutch elm disease.Thiabendazole; a thiazolyl benzimidazole available for oral administration. It is active against most common intestinal nematodes. As a result of its larvicidal and ovicidal activity, it is effective in strongyloidiasis, trichinosis, visceral larva migrans and cutaneous larva migrans. It is well absorbed from the small intestine. Peak plasma levels are reached about 1-2 h after a single oral dose of the suspension. It is extensively metabolized in the liver to the 5-hydroxy derivative, which is inactive. Most of the drug is excreted within 24 h. About 90% is excreted in the urine, chiefly as glucuronide or sulfate conjugates; the remainder is passed in the feces. A wide range of unpleasant side effects occur, including nausea and other gastrointestinal upsets, fever and neurological effects. It has been largely replaced by the less toxic benzimidazole carbamates. Although active against Ascaris lumbricoides, E. vermicularis and hookworms, it should not be used as primary therapy for these infections.2-(4-Thiazolyl)benzimidazole (Mintezol) occurs as a whitecrystalline substance that is only slightly soluble in waterbut is soluble in strong mineral acids. Thiabendazole is abasic compound with a pKa of 4.7 that forms complexeswith metal ions.Thiabendazole inhibits the helminth-specific enzymefumarate reductase. It is not known whether metal ionsare involved or if the inhibition of the enzyme is related tothiabendazole's anthelmintic effect. Benzimidazole anthelminticdrugs such as thiabendazole and mebendazolealso arrest nematode cell division in metaphase by interferingwith microtubule assembly. They exhibit a highaffinity for tubulin, the precursor protein for microtubulesynthesis.Thiabendazole has broad-spectrum anthelmintic activity.It is used to treat enterobiasis, strongyloidiasis (threadworminfection), ascariasis, uncinariasis (hookworm infection), andtrichuriasis (whipworm infection). It has also been used torelieve symptoms associated with cutaneous larva migrans(creeping eruption) and the invasive phase of trichinosis. Inaddition to its use in human medicine, thiabendazole iswidely used in veterinary practice to control i | |
2,6-Diamino-9-[3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-β-D-ribofuranosyl]purine Quick inquiry Where to buy Suppliers range | 2,6-Diamino-9-[3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-β-D-ribofuranosyl]purine, a remarkable antiviral agent utilized in the research of various viral ailments, such as herpes, hepatitis B, and the human immunodeficiency virus (HIV). Its extraordinary molecular configuration targets pivotal enzymes engaged in nucleic acid synthesis, effectively hindering viral replication and impeding the advancement of these afflictions. This unparalleled product plays a pivotal role in the realm of biomedical investigation and pharmaceutical advancement, bestowing hope in the relentless battle against insidious viral infections. Synonyms: 3',5'-TIPPS-2,6-diaminopurine riboside; 3',5'-(1,1,3,3-tetraisopropyl-1,3-disiloxan-1,3-yl)-9-(β-D-ribofuranosyl)purin-2,6-diamine; 2,6-diamino-9-(3,5-O-tetraisopropyldisiloxane-(1,3-diyl)-β-D-ribofuranosyl) purine; 3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-aminoadenosine; 9-[3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]-2,6-diaminopurine. CAS No. 87791-88-6. Molecular formula: C22H40N6O5Si2. Mole weight: 524.77. | |
2,6-Dichlorobenzonitrile Quick inquiry Where to buy Suppliers range | 2,6-Dichlorobenzonitrile (DCBN or dichlobenil) is a herbicide and is slightly toxic for humans. It is metabolized in the liver by the enzyme CYP2A6. Group: Biochemicals. Grades: Highly Purified. CAS No. 1194-65-6. Pack Sizes: 50g, 100g. Molecular Formula: C7H3Cl2N, Molecular Weight: 172.01. US Biological Life Sciences. | Worldwide |
2,6-Dichlorobenzonitrile-13C6 Quick inquiry Where to buy Suppliers range | 2,6-Dichlorobenzonitrile-13C6 is the isotope labelled analog of 2,6-Dichlorobenzonitrile (D431945); a herbicide that is slightly toxic for humans and is metabolized in the liver by the enzyme CYP2A6. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C13C6H3Cl2N, Molecular Weight: 177.97. US Biological Life Sciences. | Worldwide |
2-Acetamido-2-deoxy-3-O-(b-D-gluco-4-enepyranosyl uronic acid)-6-sulfo-D-galactopyranose disodium salt Quick inquiry Where to buy Suppliers range | 2-Acetamido-2-deoxy-3-O-(b-D-gluco-4-enepyranosyl uronic acid)-6-sulfo-D-galactopyranose disodium salt, commonly known as AMPAGUS, is a multifaceted pharmaceutical entity meticulously designed to study a wide spectrum of inflammatory ailments plaguing humanity, including the formidable rheumatoid arthritis and the insidious Crohn's disease. With its remarkable intervention abilities, AMPAGUS efficaciously regulates and subdues vital enzymatic cascades orchestrating the arduous inflammatory response. Molecular formula: C14H19NO14S.2Na. Mole weight: 503.34. | |
3',5'-Diamino-?3',?5'-?dideoxythymidine Quick inquiry Where to buy Suppliers range | 3',5'-Diamino-3',5'-dideoxythymidine is a pharmaceutical compound utilized in the biomedical industry for its antiviral properties. It is commonly employed in the research of human immunodeficiency virus (HIV) infections, inhibiting the reverse transcriptase enzyme essential for viral replication. Synonyms: 1-[(2R,4S,5R)-4-amino-5-(aminomethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; 3',5'-diNH2-5-CH3-dddU; Thymidine,3',5'-diamino-3',5'-dideoxy; 3',5'-Diamino-5-methyl-2',3',5'-trideoxyuridine. CAS No. 64638-15-9. Molecular formula: C10H16N4O3. Mole weight: 240.26. | |
(3aR,4R,12R,12aR)-3a,4,12,12a-Tetrahydro-2,2-dimethyl-4,12-epoxy-5H,8H-1,3-dioxolo[4,5-e]pyrimido[2,1-b][1,3]oxazocin-8-one Quick inquiry Where to buy Suppliers range | (3aR,4R,12R,12aR)-3a,4,12,12a-Tetrahydro-2,2-dimethyl-4,12-epoxy-5H,8H-1,3-dioxolo[4,5-e]pyrimido[2,1-b][1,3]oxazocin-8-one is a potential drug being studied in biomedicine to treat various types of cancer. It has been found to inhibit the enzyme MELK, which is overexpressed in certain cancer cells. Studies have shown promising results in inhibiting the growth of tumors in preclinical models and further research is being conducted to determine its safety and efficacy in humans. Synonyms: 2',3'-O-isopropylidene-5',6-anhydrouridine. CAS No. 3868-21-1. Molecular formula: C12H14N2O5. Mole weight: 266.25. | |
3'-Azido-3'-deoxy-beta-L-cytidine Quick inquiry Where to buy Suppliers range | 3'-Azido-3'-deoxy-beta-L-cytidine, a highly effective antiviral drug, exhibits remarkable potential in suppressing the replication of Human Immunodeficiency Virus (HIV), the notorious pathogen behind Acquired Immunodeficiency Syndrome (AIDS). Its mechanism of action involves impeding the reverse transcriptase enzyme crucial for the viral RNA to DNA conversion process. Synonyms: 4-amino-1-[(2S,3S,4R,5R)-4-azido-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one; 3'-Azido-3'-deoxy-β-L-cytidine. Grades: ≥95%. CAS No. 2095417-59-5. Molecular formula: C9H12N6O4. Mole weight: 268.23. | |
3'-Azido-3'-deoxythymidine 5'-triphosphate triethylammonium salt Quick inquiry Where to buy Suppliers range | 3'-Azido-3'-deoxythymidine 5'-triphosphate triethylammonium salt is a valuable reagent used in biomedical research. It serves as an important precursor for synthesizing antiretroviral drugs utilized in the treatment of human immunodeficiency virus (HIV) infections. This compound acts as a nucleoside analog by inhibiting reverse transcriptase, an enzyme crucial for viral replication. Synonyms: Zidovudine 5'-triphosphate triethylammonium salt. Grades: 95%. CAS No. 127753-52-0. Molecular formula: C10H16N5O13P3·3C6H15N. Mole weight: 810.75. | |
3'-Azido-5'-O-benzoyl-2',3'-dideoxyuridine Quick inquiry Where to buy Suppliers range | 3'-Azido-5'-O-benzoyl-2',3'-dideoxyuridine, a compound widely utilized in the biomedical sector, holds immense value. Its predominant application lies in antiviral therapy for combating DNA viruses like herpes simplex virus and human immunodeficiency virus. Operating as a nucleoside analog, it obstructs viral replication and facilitates the suppression of crucial viral enzymes. Due to its distinctive configuration, it exhibits substantial prospects as an antiviral agent in the treatment of these viral afflictions. Synonyms: 3'-Azido-5'-O-benzoyl-2',3'-dideoxy-D-uridine. Molecular formula: C16H15N5O5. Mole weight: 357.32. | |
3'-Azido-5'-O-tert-butyldimethylsilyl-3'-deoxythymidine Quick inquiry Where to buy Suppliers range | 3'-Azido-5'- O-tert-butyldimethylsilyl-3'-deoxythymidine, commonly known as AZT, is a highly potent antiviral compound utilized in the therapeutic intervention against human immunodeficiency virus (HIV) infection. Mechanistically, it exerts its pharmacological action as a nucleoside reverse transcriptase inhibitor, effectively restraining the activity of the reverse transcriptase enzyme pivotal for viral replication. CAS No. 1254809-15-8. Molecular formula: C16H27N5O4Si. Mole weight: 381.51. | |
3'-Azido-N4-benzoyl-5'-O-benzoyl-2',3'-dideoxycytidine Quick inquiry Where to buy Suppliers range | 3'-Azido-N4-benzoyl-5'-O-benzoyl-2',3'-dideoxycytidine, hailed as a paramount contender in the biomedical industry, exhibits remarkable efficacy as a potent antiviral agent. Renowned for its paramount significance in suppressing the replication mechanism of human immunodeficiency virus (HIV), it emerges as a breakthrough in the therapeutic armentarium of HIV infection. By perturbing the reverse transcriptase enzyme, this compound orchestrates an intricate dance, entailing the hindrance of viral DNA synthesis and the subsequent thwarting of viral replication. Molecular formula: C23H20N6O5. Mole weight: 460.44. | |
3'-Azido-N6-benzoyl-2',3'-dideoxyadenosine Quick inquiry Where to buy Suppliers range | 3'-Azido-N6-benzoyl-2',3'-dideoxyadenosine is a remarkably potent antiviral compound extensively employed in the biomedical sector, exhibiting remarkable inhibitory potential against diverse viral strains, encompassing the notorious human immunodeficiency virus (HIV) and hepatitis B virus (HBV). It exerts its efficacy by selectively deterring the replication of these malicious microorganisms through actuating an impediment upon their crucial enzymatic machinery. Synonyms: 3'-AZIDO-N6-BENZOYL-2',3'-DIDEOXYADENOSINE; 869354-89-2; MFCD01630962; N6-Benzoyl-3'-azido-2',3'-dideoxyadenosine; J-700075; 110143-02-7. Grades: ≥ 90%. CAS No. 869354-89-2. Molecular formula: C17H16N8O3. Mole weight: 380.37. | |
3-(Boc-aminomethyl)benzoic Acid Quick inquiry Where to buy Suppliers range | 3-(Boc-aminomethyl)benzoic Acid is used to synthesize aminodi hydroquinazolines as inhibitors of BACE-1 ( β-site APP cleaving enzyme). It is also used to prepare spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 117445-22-4. Pack Sizes: 500mg, 1g. Molecular Formula: C13H17NO4, Molecular Weight: 251.28. US Biological Life Sciences. | Worldwide |
3'-Deoxy-3',4'-didehydrocytidine Quick inquiry Where to buy Suppliers range | 3'-Deoxy-3',4'-didehydrocytidine is a remarkable and efficacious pharmaceutical compound widely employed to study the deleterious effects of both hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections. This formidable nucleoside analogue showcases an extraordinary affinity towards viral polymerase enzymes, rendering it an unparalleled and efficacious course of reserch for individuals afflicted by these insidious viral afflictions. CAS No. 1823793-27-6. Molecular formula: C9H11N3O4. Mole weight: 225.20. | |
(3R,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinone Quick inquiry Where to buy Suppliers range | (3R,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinone is a biomedically relevant substance used in pharmaceutical formulations. It helps in diabetes management by serving as a potent inhibitor of human aldose reductase, a key enzyme involved in pathogenic complications of diabetes. Molecular formula: C5H9NO4. Mole weight: 147.13. | |
4',5'-Didehydro-5'-deoxythymidine Quick inquiry Where to buy Suppliers range | 4',5'-Didehydro-5'-deoxythymidine, a potent antiviral agent, exhibits remarkable efficacy in combatting a multitude of viral afflictions encompassing human immunodeficiency virus (HIV) as well as hepatitis B virus (HBV). By imposing a formidable inhibition upon reverse transcriptase, an indispensable viral replication enzyme, its therapeutic prowess manifests. Synonyms: 1-(2,5-dideoxy-β-D-glycero-pent-4-enofuranosyl)thymine; 4',5'-didehydro-5'-deoxy-thymidine; 5'-Deoxy-4',5'-didehydrothymidine; 1-((2R,4S)-4-hydroxy-5-methylenetetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; 1-[(2R,4S)-4-Hydroxy-5-methylenetetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione. Grades: ≥95%. CAS No. 28034-72-2. Molecular formula: C10H12N2O4. Mole weight: 224.22. | |
4-Chloro-DL-phenylalanine Quick inquiry Where to buy Suppliers range | 4-Chloro-DL-phenylalanine is a pharmaceutical intermediate. It acts as a selective and irreversible inhibitor of tryptophan hydroxylase. It is a rate-limiting enzyme in the biosynthesis of serotonin. It has been used experimentally to treat carcinoid syndrome. It is used in scientific research in humans and animals to investigate the effects of serotonin depletion. It binds irreversibly to tryptophan hydroxylase to cause depletion of serotonin in the brain. Uses: 4-chloro-dl-phenylalanine has been used experimentally to treat carcinoid syndrome. it is used in scientific research in humans and animals to investigate the effects of serotonin depletion. it binds irreversibly to tryptophan hydroxylase to cause depletion of serotonin in the brain. Synonyms: CP-10,188; CP10,188; CP 10,188; CP-10188; CP10188; CP 10188; Fenclonine; DL-3-(4-Chlorophenyl)alanine; Fenclonin; NSC 77370; p-Clorophenylalanine.; DL-4-Chlorophenylalanine;p-Chlorophenylalanine;(S)-2-amino-3-(4-chlorophenyl)propanoic acid;2-Amino-3-(4-chlorophenyl)propanoic acid; DL-3-(4-Chlorophenyl)alanine; Fenclonin; Fenclonine; PCP; PCPA; CP-10188. Grades: ≥ 99% (HPLC). CAS No. 7424-00-2. Molecular formula: C9H10ClNO2. Mole weight: 199.63. | |
4-Diethylaminobenzaldehyde Quick inquiry Where to buy Suppliers range | DEAB is a potent inhibitor of cytosolic (class 1) aldehyde dehydrogenase (ALDH) enzymes (IC50 values 0.057 μM, 1.2 μM, 3.0 μM, 1.2 μM, 0.16 μM, and 13 μM for inhibition of ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, and ALDH5A1, respectively). DEAB is also an excellent substrate for ALDH3A1, and an irreversible inhibitor of ALDH7A1 (KI value 100 μM). Uses: 4-(diethylamino)benzaldehyde is a mechanism-based inhibitor for human aldehyde dehydrogenase isoenzymes. potent and reversible inhibitor of mouse and human class i aldehyde dehydrogenase. Synonyms: 4-(diethylamino)benzaldehyde. Grades: 99 %. CAS No. 120-21-8. Molecular formula: C11H15NO. Mole weight: 177.24. | |
4-IPP Quick inquiry Where to buy Suppliers range | 4-IPP is a potent and cell-permeable macrophage migration inhibitory factor (MIF) antagonist. It covalently modifies MIF N-terminal proline. It inhibits MIF-associated liver enzyme activity in vivo and acts as a suicide substrate to inactivate MIF biological and catalytic functions. It also inhibits anchorage and migration independence of human lung adenocarcinoma cell lines in vitro. Synonyms: 4-IPP; 4 IPP; 4IPP; 4-Iodo-6-phenylpyrimidine. Grades: ≥99% by HPLC. CAS No. 41270-96-6. Molecular formula: C10H7IN2. Mole weight: 282.08. | |
4-Pyridinecarbonitrile Quick inquiry Where to buy Suppliers range | A derivative of Fampridine. Fampridine is a potent convulsant. Uses: 4-cyanopyridine is a reagent for the synthesis of 1-tolyl-5-benzylthiotetrazole and 2-hexylthio-4-pyridinecarbonitrile, an antituberculotics. preparation of the antihypertensive agent pinacidil using the chemoselective and green oxidative rearrangement of an amidine and addition of an amine to a guanidine as the key step. structure-based discovery of human l-xylulose reductase inhibitors from database screening and molecular docking. human l-xylulose reductase (xr) is an enzyme of the glucuronic acid/uronate cycle of glucose metabolism with the possible target for treatment of the long-term complications of diabetes. Synonyms: pyridine-4-carbonitrile. Grades: > 95 %. CAS No. 100-48-1. Molecular formula: C6H4N2. Mole weight: 104.11. | |
4SC-202 Tosylate Quick inquiry Where to buy Suppliers range | 4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. HDAC inhibitor 4SC-202 selectively binds to and inhibits class I HDACs leading to an accumulation of highly acetylated histones.This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, upregulated in many tumor types, are a class of enzymes that deacetylate chromatin histone proteins. Synonyms: 4SC-202; 4SC 202; 4SC202. Grades: 0.98. CAS No. 1186222-89-8. Molecular formula: C30H29N5O6S2. Mole weight: 619.711. | |
5-Hydroxymethylcytidine Quick inquiry Where to buy Suppliers range | 5-Hydroxymethylcytosine is a DNA pyrimidine nitrogen base. It is formed from the DNA base cytosine by adding a methyl group and then a hydroxy group. It is important in epigenetics, because the hydroxymethyl group on the cytosine can possibly switch a gene on and off. It was first seen in bacteriophages in 1952.[1][2] However, in 2009 it was found to be abundant in human and mouse brains,[3] as well as in embryonic stem cells.[4] In mammals, it can be generated by oxidation of 5-methylcytosine, a reaction mediated by the Tet family of enzymes. 5-Hydroxymethylcytidine is a product in DNA hydroxymethylation. The concentrations of 5-Hydroxymethylcytidine in the brain were used to study Alzheimers disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 19235-17-7. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
5-L-Isoleucineangiotensin II Quick inquiry Where to buy Suppliers range | 5-L-Isoleucineangiotensin II is an endogenous potent vasoconstrictor peptide typically generated by the removal of two residues from angiotensin I by angiotensin-converting enzyme (ACE) by binding to both the AT1 and the AT2 receptors. Uses: An endogenous potent vasoconstrictor peptide. Synonyms: 5-Isoleucine-angiotensin II; L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine; Angiotensin II human; Human angiotensin II; Hypertensin; H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH; Angiotensin II, 5-L-isoleucine-; Alanine, N-[1-[N-[N-[N-[N-(N2-L-α-aspartyl-L-arginyl)-L-valyl]-L-tyrosyl]-L-isoleucyl]-L-histidyl]-L-prolyl]-3-phenyl-, L-; 5-L-Isoleucine-angiotensin II; L-Phenylalanine, N-[1-[N-[N-[N-[N-(N2-L-α-aspartyl-L-arginyl)-L-valyl]-L-tyrosyl]-L-isoleucyl]-L-histidyl]-L-prolyl]-; [Ile5]-Ang II; [Ile5]-Angiotensin II; Angiotensin 2; Angiotensin II; Angiotensin II (human); Angiotensin II (mouse); Angiotensin II [Ile5]; Asp1-Ile5-angiotensin II; Human angiotensin II; Ileu5-angiotensin II; Isoleucyl5-angiotensin II. Grades: 98%. CAS No. 4474-91-3. Molecular formula: C50H71N13O12. Mole weight: 1046.19. | |
5'-O-Acetyl-2',3'-dideoxyinosine Quick inquiry Where to buy Suppliers range | 5'-O-Acetyl-2',3'-dideoxyinosine is an extensively utilized potent antiviral compound within the biomedical field, exhibiting impressive efficacy in research of viral infections induced by the human immunodeficiency virus (HIV). By impeding the reverse transcriptase enzyme, a pivotal factor for viral replication, this compound effectively impedes viral multiplication. Synonyms: 5'-O-Acetyldidanosine; 5'-O-Acetyl-2',3'-dideoxy-D-inosine. CAS No. 130676-58-3. Molecular formula: C12H14N4O4. Mole weight: 278.26. | |
5'-O-tert-Butyldimethylsilyl-2',3'-dideoxy-3'-fluorouridine Quick inquiry Where to buy Suppliers range | 5'-O-tert-Butyldimethylsilyl-2',3'-dideoxy-3'-fluorouridine, an indispensable compound in the biomedical field, holds immense significance. Widely employed for tackling viral infections induced by specific retroviruses, such as Human Immunodeficiency Virus (HIV), it showcases remarkable antiviral attributes through the inhibition of reverse transcriptase, a pivotal viral replication enzyme. Synonyms: 5'-O-tert-Butyldimethylsilyl-2',3'-dideoxy-3'-fluoro-D-uridine. Molecular formula: C15H25FN2O4Si. Mole weight: 344.45. | |
5-TFA-ap-2',3'-Dideoxycytidine Quick inquiry Where to buy Suppliers range | 5-TFA-ap-2',3'-Dideoxycytidine, a nucleoside analogue implemented as an antiviral agent to counteract human immunodeficiency virus (HIV) infections, functions by obstructing the reverse transcriptase enzyme crucial for viral replication. Its utilization as a potent antiviral compound has been studied extensively due to its promising therapeutic capabilities in restraining the detrimental spread of HIV. Synonyms: 5-[(Trifluoracetyl)amino]propynyl-ddC; 5-TFA-ap-ddC; 2',3'-Dideoxy-5-[3-[(trifluoroacetyl)amino]-1-propynyl]-cytidine; Cytidine, 2',3'-dideoxy-5-[3-[(trifluoroacetyl)amino]-1-propynyl]-; 5-(3-Trifluoroacetamido-1-propynyl)-2',3'-dideoxycytidine; N-(3-{4-Amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydro-2-furanyl]-2-oxo-1,2-dihydro-5-pyrimidinyl}-2-propyn-1-yl)-2,2,2-trifluoroacetamide. Grades: ≥97% by HPLC. CAS No. 114748-58-2. Molecular formula: C14H15F3N4O4. Mole weight: 360.29. | |
6-Methylchrysene Quick inquiry Where to buy Suppliers range | 6-Methylchrysene, a polycyclic aromatic hydrocarbon, has been postulated as a potential carcinogen and may increase the likelihood of developing lung and skin cancer. Due to its carcinogenic properties, this compound is commonly employed in research to investigate the health risks posed by PAH and examine measures to mitigate such threats. Further studies indicate that catabolism of 6-Methylchrysene by enzymes CYP1A1 and CYP1B1 produces deleterious metabolites, implying that these enzymes could possibly contribute to the development of specific cancers. The intricate relationship between 6-Methylchrysene and cancer has encouraged extensive research to comprehend the mechanisms by which it adversely affects human health. CAS No. 1705-85-7. Molecular formula: C19H14. Mole weight: 242.321. | |
6-Nitroveratraldehyde Quick inquiry Where to buy Suppliers range | DMNB is a derivative of vanillin with 100-fold potency compared to vanillin, and acts as an inhibitor of DNA-dependent protein kinase (DNA-PK) (IC50 = 15 μM). DNA-PK is an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Uses: Dmnb is a vanillin compound, which is a type of dna-pk inhibitor. Synonyms: 4,5-dimethoxy-2-nitrobenzaldehyde. Grades: ≥ 98 % by HPLC. CAS No. 20357-25-9. Molecular formula: C9H9NO5. Mole weight: 211.17. | |
7-Azido-4-methylcoumarin (AzMC) Quick inquiry Where to buy Suppliers range | Highly sensitive and selective fluorogenic H2S probe. The aromatic azide moiety of AzMC is selectively reduced in the presence of H2S, producing the fluorescent 7-amino-4- methylcoumarin (AMC) with a concomitant increase in fluorescence with lambdaex=365nm and lambdaem=450nm. Photoaffinity labeling probe for the substrate binding site of human sulfotransferase 1A1 (SULT1A1). Probe to monitor the enzymatic production of H2S in vitro and to visualize H2S in living cells. Tool for monitoring the activity of pyridoxal-5'-phosphate (PLP)-dependent enzymes (e.g. cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CGL) and tryptophan synthase (TS)). Tool to identify novel cystathionine beta-synthase (CBS) inhibitors and activators. Suitable for high-throughput screening. Use of this product with DTT, TCEP and/or biological thiols at concentrations of >25mM should be avoided for maximum efficiency. Group: Biochemicals. Grades: Highly Purified. CAS No. 95633-27-5. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
7'-OH-N-DMTr morpholino-5-methyluracil Quick inquiry Where to buy Suppliers range | 7'-OH-N-DMTr morpholino-5-methyluracil is a revolutionary and groundbreaking compound, intricately designed to study a myriad of ailments plaguing humanity. This unparalleled concoction emerges as an exquisite methyltransferase inhibitor, meticulously honing in on select enzymes participating in the delicate orchestration of DNA methylation. Synonyms: N-DMTr-morpholino-T. Grades: ≥95%. Molecular formula: C31H33N3O6. Mole weight: 543.61. | |
8-[(6-Amino)hexyl]-amino-GTP - ATTO-665 Quick inquiry Where to buy Suppliers range | 8-[(6-Amino)hexyl]-amino-GTP - ATTO-665, a fluorescent analog of GTP, functions as a critical resource for the investigation of GTP-binding proteins in cancer and neurological disease research. Its in vitro utilization enables the examination of GTPase enzyme dynamics, especially in their association with effector proteins. The product's existence enhances comprehension regarding the different GTP-controlled cellular events that participate in the progression of various diseases that afflict humanity. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with ATTO 665, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H30N7O14P3- ATTO 665 (free acid). Mole weight: 1241.37 (free acid). | |
8-Bromo-3'-deoxy-3'-fluoroguanosine Quick inquiry Where to buy Suppliers range | 8-Bromo-3'-deoxy-3'-fluoroguanosine, an intriguing biomedical compound, holds immense potential in the realm of antiviral drug research and development. Its proven efficacy against formidable viruses such as herpes simplex and human immunodeficiency virus (HIV) fuels scientific curiosity. By delving into the enzymatic activities, mechanisms, and inhibition of viral replication, this compound serves as a vital tool driving progress in the field of antiviral therapeutics. Synonyms: 2-amino-8-bromo-9-[(2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one. Grades: ≥95%. CAS No. 847649-50-7. Molecular formula: C10H11BrFN5O4. Mole weight: 364.13. | |
A-740003 Quick inquiry Where to buy Suppliers range | A-740003 is potent, selective and competitive P2X7 receptor antagonist. Its IC50 values are 18 and 40 nM for rat and human receptors respectively measured by agonist-stimulated changes in intracellular calcium concentrations. It displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 μM. It reduces nociception in animal models of persistent neuropathic and inflammatory pain. It showed weak or no activity (IC(50) > 10 muM) at other P2 receptors and an array of other neurotransmitter and peptide receptors, ion channels, reuptake sites, and enzymes. It potently blocked agonist-evoked IL-1beta release (IC(50) = 156 nM) and pore formation (IC(50) = 92 nM) in differentiated human THP-1 cells. It produces significant antinociception in animal models of neuropathic and inflammatory pain in vivo. Uses: A-740003 produces significant antinociception in animal models of neuropathic and inflammatory pain in vivo. Synonyms: A-740003; A 740003; A740003; N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide;N-(1-{[(cyanoimino)(5-quinolinylamino) methyl] amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide. Grades: >98 %. CAS No. 861393-28-4. Molecular formula: C26H30N6O3. Mole weight: 474.55. | |
ABX-1431 Quick inquiry Where to buy Suppliers range | ABX-1431 is an inhibitor of monoacylglycerol lipase (MAGL; IC50s = 14 and 27 nM for human and rat enzyme, respectively). Synonyms: 1,1,1,3,3,3-hexafluoropropan-2-yl 4-[[2-pyrrolidin-1-yl-4- (trifluoromethyl) phenyl]methyl]piperazine-1-carboxylate. Grades: ≥98%. CAS No. 1446817-84-0. Molecular formula: C20H22F9N3O2. Mole weight: 507.3. | |
Acifran Quick inquiry Where to buy Suppliers range | Acifran is a nicotinic acid receptor agonist with hypolipidemic effects, which shows higher potency than nicotinic acid and clofibrate. It is a potent and full agonist at the human orphan GPCR HM74A/GPR109A and GPR109B. It reduces circulating LDL-cholesterol and serum triglycerides in vivo without affecting liver enzymes or liver weight. Synonyms: AY 25712; AY-25712; AY25712; 4,5-Dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylic acid; (±)-Acifran; Reductol. Grades: ≥99% by HPLC. CAS No. 72420-38-3. Molecular formula: C12H10O4. Mole weight: 218.21. | |
Aflatoxin Q1 Quick inquiry Where to buy Suppliers range | Aflatoxin Q1 is a metabolite of Aflatoxin B1. It is created in human body as a in-vivo detoxification process of Aflatoxin B1. Uses: A metabolite of aflatoxin b1; a hepatocarcinogen in many animal models and probably a human carcinogen. it is produced by the predominant forms of cytochrome p 450 enzymes responsible for the biotransformation of afb1. it shows potential predictive value. Synonyms: Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-3-hydroxy-4-methoxy-, (3S,6aR,9aS)-; Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-3-hydroxy-4-methoxy-, (3S-(3-alpha,6a-alpha,9a-alpha))-; (3S, 6aR, 9aS)-3-hydroxy-4-methoxy-2, 3, 6a, 9a-tetrahydrocyclopenta[c]furo[3', 2':4, 5]furo[2, 3-h]chromene-1, 11-dione. Grades: ≥98%. CAS No. 52819-96-2. Molecular formula: C17H12O7. Mole weight: 328.27. | |
AG-213 Quick inquiry Where to buy Suppliers range | AG-213 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 2.4 μM in the human epidermoid carcinoma cell line A431. Uses: Enzyme inhibitors. Synonyms: Tyrphostin AG-213; Tyrphostin 47; (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethioamide. Grades: ≥97%. CAS No. 122520-86-9. Molecular formula: C10H8N2O2S. Mole weight: 220.2. | |
Altenusin Quick inquiry Where to buy Suppliers range | Altenusin is a a biphenyl derivative with an IC50 value of 4.3±0.3 μM in the TR assay, which is isolated from the endophytic fungus Alternaria. It inhibits Src kinase with an IC50 value of 20 nM. Altenusin inhibits fibrillization of recombinant tau fragments in vitro and phosphorylation of tau in SH-SY5Y cells expressing human P301L mutant tau when used at a concentration of 10 μM. Altenusin is known to have antioxidant properties and to inhibit several enzymes, including myosin light chain kinase, sphingomyelinase, acetylcholinesterase, cFMS kinase, pp60c-SRc kinase and HIV-1 integrase. Synonyms: Alutenusin; MS 341; MS-341; MS341. Grades: ≥98%. CAS No. 31186-12-6. Molecular formula: C15H14O6. Mole weight: 290.27. | |
AM-643 Quick inquiry Where to buy Suppliers range | AM-643 is an active molecular. In the Biological Tests, it can inhibit FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 5 hrs by ELISA and the activity value is 0.081μM. It can also Inhibit COX1-mediated TXB2 production in human whole blood after 30 mins by competitive enzyme immunoassay and the activity value is 25μM. Synonyms: AM-643 Free Acid; AM643 Free Acid; UNII-55668SZQ3E;3-(3-(tert-butylthio)-1-(4-(5-methoxypyrimidin-2-yl)benzyl)-5-((5-methylpyridin-2-yl)methoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid. Grades: 98%. CAS No. 1233114-22-1. Molecular formula: C36H40N4O4S. Mole weight: 642.79. | |
Aminopeptidase N Inhibitor Quick inquiry Where to buy Suppliers range | Membrane alanyl aminopeptidase is also known as alanyl aminopeptidase (AAP) or aminopeptidase N (AP-N), which is an enzyme that in humans is encoded by the ANPEP gene. Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. Synonyms: AP-N Inhibitor. Grades: ≥95%. CAS No. 596108-59-7. Molecular formula: C17H10N2O8. Mole weight: 370.27. | |
AMPK Signaling Agonist, F17 (4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide) Quick inquiry Where to buy Suppliers range | A cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~0.1uM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-a1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25uM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C. Group: Biochemicals. Grades: Highly Purified. CAS No. 280112-24-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Angiotensin 1 Human Quick inquiry Where to buy Suppliers range | Angiotensin 1 (Human) is the precursor to the vasoconstrictor peptide angiotensin II, cleaved by the angiotensin-converting enzyme (ACE). Uses: Peptide Inhibitors. CAS No. 484-42-4. Product ID: R1197. | |
Angiotensin I (1-9) Quick inquiry Where to buy Suppliers range | Angiotensin I (1-9) is a 9-amino acid peptide formed when Angiotensin converting enzyme 2 (ACE2) hydrolyzes the carboxy-terminal leucine of Angiotensin I. It is an anti-cardiac hypertrophy drug with the functions of human metabolite, rat metabolite, antihypertensive agent and cardiac protective agent. Synonyms: H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-OH; L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidine; L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro-L-Phe-L-His. Grades: ≥95% by HPLC. CAS No. 34273-12-6. Molecular formula: C56H78N16O13. Mole weight: 1183.32. | |
Angiotensin I human acetate salt hydrate Quick inquiry Where to buy Suppliers range | Angiotensin 1 (Human), an endogenous peptide substrate for angiotensin converting enzyme (ACE), is precursor to the vasoconstrictor peptide angiotensin II. Synonyms: H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH.CH3CO2H.H2O. CAS No. 70937-97-2. Molecular formula: C64H95N17O17. Mole weight: 1374.54. | |
Angiotensin I (human, mouse, rat) Quick inquiry Where to buy Suppliers range | Angiotensin 1 (Human), an endogenous peptide substrate for angiotensin converting enzyme (ACE), is precursor to the vasoconstrictor peptide angiotensin II. Synonyms: Angiotensin 1 Human; H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH; L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucine; Pepsitensin; Proangiotensin; 5-Ile-angiotensin I; 5-L-Isoleucine-angiotensin I. Grades: ≥95%. CAS No. 484-42-4. Molecular formula: C62H89N17O14. Mole weight: 1296.48. | |
Angiotensin I (human, rat, mouse) trifluoroacetate salt Quick inquiry Where to buy Suppliers range | Angiotensin I is formed from angiotensinogen by the action of renin, which is released from the kidney juxtaglomerular cells. Angiotensin I is further cleaved to angiotensin II by angiotensin converting enzyme. Angiotensin is a protein hormone that causes blood vessels to become narrower. It helps to maintain blood pressure and fluid balance in the body. It binds to angiotensin receptors in human myometrium membrane preparations with Kd of 11.2 nM and increases renal vascular resistance in isolated rat kidney with EC50 of 10.5 nM. Grades: ≥95%. Molecular formula: C62H89N17O14·xCF3COOH. Mole weight: 1296.48. | |
Angiotensin II (1-4), human Quick inquiry Where to buy Suppliers range | Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels. Angiotensin II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney. Uses: Peptide Inhibitors. CAS No. 52580-29-7. Product ID: R1200. | |
Angiotensin II (1-4), human Quick inquiry Where to buy Suppliers range | Angiotensin II (1-4), human is an endogenous peptide produced from ATI by angiotensin-converting-enzyme (ACE). Synonyms: H-DRVY-OH; L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosine; (S)-3-amino-4-((S)-1-((S)-1-((S)-1-carboxy-2-(4-hydroxyphenyl)ethylamino)-3-methyl-1-oxobutan-2-ylamino)-5-guanidino-1-oxopentan-2-ylamino)-4-oxobutanoic acid; L-α-Aspartyl-N5-(diaminomethylene)-L-ornithyl-L-valyl-L-tyrosine. Grades: ≥95%. CAS No. 52580-29-7. Molecular formula: C24H37N7O8. Mole weight: 551.59. | |
APC 366 trifluoroacetate salt Quick inquiry Where to buy Suppliers range | APC 366 is a mast cell tryptase inhibitor with Ki of 7.1 μM for human recombinant enzyme. It is a selective inhibitor of mast cell tryptase, which has been shown to inhibit antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma. APC 366 can reduce maximum contractile response to histamine in isolated bronchial tissue from ovalbumin-sensitized guinea pigs. It can also reduce airway resistance and increases dynamic lung compliance in A. suum antigen-challenged pigs. Grades: ≥95%. Molecular formula: C22H28N6O4·xCF3COOH. Mole weight: 440.50. | |
ARN 14686 Quick inquiry Where to buy Suppliers range | ARN14686 is a NAAA (N-acylethanolamine acid amidase) activity-based protein profiling (ABPP) probe. ARN14686 can be used to detect NAAA by using click chemistry in cell lysates or intact cells, which binds covalently to the N-terminal cysteine of catalytically active NAAA to form a thioester adduct. ARN14686 inhibits the hydrolysis of the NAAA substrate PAMCA in HEK293 cells. The IC50s for human is 6 and the IC50s for rat recombinant enzymes is 13 nM. Synonyms: (S)-Undec-10-yn-1-yl (2-oxoazetidin-3-yl)carbamate. Grades: ≥98% by HPLC. CAS No. 1628345-10-7. Molecular formula: C15H24N2O3. Mole weight: 280.36. | |
ARN14988 Quick inquiry Where to buy Suppliers range | ARN14988 can normalize ceramide levels and concomitantly sensitize proliferative melanoma cells to the cytotoxic actions of various antitumoral agents. ARN14988 is a potent inhibitor of acid ceramidase with IC50 of 12.8 nM for the human enzyme. ARN14988 also reduces growth of A375 with EC50s of 41.8 μM and G361 with EC50s of 67.7 μM. Synonyms: ARN 14988; ARN-14988. Grades: ≥98%. CAS No. 1502027-70-4. Molecular formula: C16H24ClN3O5. Mole weight: 373.83. | |
ARRY 403 Quick inquiry Where to buy Suppliers range | ARRY-403 is an orally available Glucokinase stimulants originated by Array BioPharma. ARRY-403 activates human glucokinase in vitro with EC50 of 79 nM at 5 mM glucose and Vmax = 134% compared to the no activator control. It exhibits good in vitro drug-like properties and selectivity against broad panels of receptors and enzymes. But,treatment for Type 2 diabetes mellitus was discontinued. Uses: Type 2 diabetes mellitus. Synonyms: ARRY-403; ARRY-403; ARRY-403; AMG-151; AMG 151; AMG151;(1S)-1-[5-({3-[(2-methylpyridin-3-yl)oxy]-5-(pyridin-2-ylsulfanyl)pyridin-2-yl}amino)-1,2,4-thiadiazol-3-yl]ethane-1,2-diol. Grades: 98%. CAS No. 1304015-76-6. Molecular formula: C20H18N6O3S2. Mole weight: 454.53. | |
AS1940477 Quick inquiry Where to buy Suppliers range | AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blood mononuclear cells, AS1940477 inhibited lipopolysaccharide (LPS)- or phytohemagglutinin A (PHA)-induced production of proinflammatory cytokines, including TNFα, IL-1β, and IL-6 at low concentrations (LPS/TNFα, IC(50)=0.45n M; PHA/TNFα, IC(50)=0.40 nM). In addition, equivalent concentrations of AS1940477 that inhibited cytokine production also inhibited TNFα- and IL-1 β-induced production of IL-6, PGE(2), and MMP-3 in human synovial stromal cells. AS1940477 was also found to potently inhibit TNF production in whole blood (IC(50)=12 nM) and effectively inhibited TNFα production induced by systemically administered LPS in rats at less than 0.1mg/kg (ED(50)=0.053 mg/kg) with an anti-inflammatory effect lasting for 20h after oral administration. Overall, this study demonstrated that AS1940477 is a novel and potent p38 MAPK inhibitor and may be useful as a promising anti-inflammatory agent for treating inflammatory disorders. Synonyms: AS1940477; AS-1940477; AS 1940477. CAS No. 928344-12-1. Molecular formula: C24H22FN5O2. Mole weight: 431.47. | |
AS-605240 potassium salt Quick inquiry Where to buy Suppliers range | Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. AS-605240 inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively. AS-605240 also inhibits C5a-mediated phosphorylation of protein kinase B in RAW 264 cells with an IC50 value of 90 nM. AS-605240 potassium salt is the potassium salt form of AS-605240, which increase the water-solubility. Synonyms: AS-605240. Grades: ≥98%. Molecular formula: C12H6N3O2S·K. Mole weight: 295.4. | |
Atazanavir Quick inquiry Where to buy Suppliers range | Atazanavir is a novel and potent azapeptide protease inhibitor that specifically inhibits the human immunodeficiency virus type 1 (HIV-1) protease enzyme with inhibition constant Ki of 66 nmol/L and also inhibits the viral replication of HIV-1 with 50% effective concentration EC50 ranging from 2.6 to 5.3 nmol/L. Atazanavir binds to HIV-1 protease preventing the cleavage of gag and gag-pol polyproteins, which results in the formation of immature virions in HIV-1-infected cells. Atazanavir has a different C-2 symmetric chemical structure and a generally greater antiretroviral potency in various HIV strains compared to other protease inhibitors, including indinavir, nelfinavir, ritonavir, saquinavir and amprenavir. Synonyms: Atazanavir ; Reyataz ; Atazanavir sulfate ; CGP75136 ; CGP75176 ; CGP75355 ; BMS232632 ; CGP 73547 ; CGP 75136 ; CGP 75176 ; CGP 75355 ; CGP-73547 ; CGP-75136 ; CGP-75176 ; CGP-75355 ; BMS 232632 ; BMS-232632 ; BMS-232632-05 ; C413408. Grades: 0.98. CAS No. 198904-31-3. Molecular formula: C38H52N6O7. Mole weight: 704.869. | |
Atto 590 nhs ester Quick inquiry Where to buy Suppliers range | ATTO 590 is a novel fluorescent label belonging to the class of Rhodamine dyes. The dye is designed for application in the area of life science, e.g. labeling of DNA, RNA or proteins. The ATTO dyes are a series of fluorescent dyes that provide all the crucial properties required for modern fluorescent technologies, such as fluorescence microscopy, flow-cytometry, fluorescence in situ hybridization (FISH), receptor binding assays or enzyme assays. The dye is highly suitable for single-molecule detection applications and high-resolution microscopy. The NHS-esters are used in common conjugation protocols.ATTO 590 is a novel fluorescent label belonging to the class of Rhodamine dyes, which has an absorption maximum of 594 nm and an emission maximum of 624 nm. ATTO 590-N-hydroxysuccinimide (NHS) is membrane permeable. Uses: Molar absorption 120,000 1/m cm, abs: 593 nm, em: 620 nm, qy=0.93, tfl 4.0 ns (unpublished data)atto 590 nhs ester may be suitable for use in site-specific labeling of human embryonic kidney (hek293t) cell lysates for western blotting, fluorescence, and widefield microscopy studies. Synonyms: 2-(6, 20-diethyl-7, 7, 9, 17, 19, 19-hexamethyl-2-oxa-20-aza-6-azoniapentacyclo[12.8.0.03, 12.05, 10.016, 21; docosa-1(14),3,5,8,10,12,15,17,21-nonaen-13-yl)-4-(2,5-dioxopyrrolidin-1-yl)oxycarbonylbenzoic acid;perchlorate; 6-(2-Carboxy-5-{[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}phenyl)-1,11-diethyl-2,2,4,8,10,10-hexamethyl-10,11-dihydro-2H-pyrano[3,2-g:5,6-g']diquinolin-1-ium perchlorate. Grades: ≥60% (coupling to amines). CAS No. 670269-33-7. Molecular formula: C41H42ClN3O11. Mole weight: 788.24. | |
AUNP-12 Quick inquiry Where to buy Suppliers range | AUNP-12 is highly effective in antagonizing PD-1 signaling, with desirable in vivo exposure upon subcutaneous dosing. It inhibits tumor growth and metastasis in preclinical models of cancer and is well tolerated with no overt toxicity at any of the tested doses. Soluble epoxide hydrolase (sEH) catalyzes the conversion of EpETrEs to the corresponding dihydroxy eicosatrienoic acids (DiHETrEs) thereby diminishing their activity. AUDA is an inhibitor of sEH exhibiting IC50 of 18 nM for the mouse and IC50 of 69 nM forand human enzymes. Synonyms: Aur-012; Aurigene-012; Aurigene NP-12. Grades: ≥95%. CAS No. 1353563-85-5. Molecular formula: C142H226N40O48. Mole weight: 3261.55. | |
Autotaxin Inhibitor III, PF-8380 (Atx Inhibitor III, PF-8380, 6-(3-(Piperazin-1-yl)propanoyl)-benzo[d]oxazol-2(3H)-one) Quick inquiry Where to buy Suppliers range | An orally bioavailable piperazinyl benzoxazolone compound that acts as a substrate competitive and tight-binding inhibitor of autotaxin activity {IC50=2.8 and 1.7nM for recombinant human enzyme-b isoform employing FS-3 and LPC (lysophosphatidyl choline) as substrates, respectively; 1.16 and 1.15nM for rat/murine enzyme-FS-3 and fetal fibroblast cell-LPC; 101nM for human whole blood}. Displays desirable pharmacokinetics properties and efficiently blocks inflammation-induced LPA (lysophosphatidic acid) production both in plasma and at the site of inflammation by 95% in rat adjuvant-induced arthritis model (30mg/kg, p.o.).CAS No:1144035-53-9. Group: Biochemicals. Grades: Highly Purified. CAS No. 1144035-53-9. Pack Sizes: 10mg. Molecular Formula: C??H??Cl?N?O?. US Biological Life Sciences. | Worldwide |
Az-33 Quick inquiry Where to buy Suppliers range | Az-33 is a lactate dehydrogenase A (LDHA) inhibitor, which is a key enzyme in anaerobic glycolysis process and is deregulated in human malignancies. Uses: Az-33 is a lactate dehydrogenase a (ldha) inhibitor. Synonyms: Az 33; Az33; 2-(4-(4-((3-((2-Methylbenzo[d]thiazol-6-yl)amino)-3-oxopropyl)amino)-4-oxobutyl)benzyl)malonic acid. Grades: ≥98%. CAS No. 1370290-34-8. Molecular formula: C25H27N3O6S. Mole weight: 497.56. | |
Benzyl 2-O-[2-(Acetylamino)-2-deoxy-β-D-glucopyranosyl]-α-D-mannopyranoside Quick inquiry Where to buy Suppliers range | A product formed from Benzyl α-D-mannopyranoside by α-3-D-mannoside by the enzyme UDP-GlcNAc:α-3-D-mannoside β1,2-N-acetylglucosaminyltransferase I.2 in humans. Synonyms: GlcNAc(β1-2)Man(α1-)O-benzyl; Phenylmethyl 2-O-[2-(Acetylamino)-2-deoxy-D-glucopyranosyl]-α-D-mannopyranoside. CAS No. 436853-00-8. Molecular formula: C21H31NO11. Mole weight: 473.37. |