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| Product | Description | |
|---|---|---|
| Epidermal Growth Factor | Epidermal Growth Factor (EGF) is a protein that stimulates the proliferation of different types of cells via binding to its receptor EGFR. EGF has been found in many human tissues such as submandibular gland and parotid gland. Synonyms: EGF. Molecular formula: C257H381N73O83S7. Mole weight: 6046. |  |
| Epidermal Growth Factor, human (hEGF) | recombinant (E. coli). Group: Fluorescence/luminescence spectroscopy. |  |
| Epidermal Growth Factor Receptor human | lyophilized powder, ?15,000 units/mg protein (Bradford). Group: Fluorescence/luminescence spectroscopy. | |
| Epidermal Growth Factor Receptor, non-phosphorylated (erbB, EGFR) | Epidermal Growth Factor Receptor, non-phosphorylated (erbB, EGFR). Group: Molecular Biology. Grades: Purified. Pack Sizes: 100ug. US Biological Life Sciences. |  Worldwide |
| Epidermal Growth Factor Receptor Peptide acetate | Epidermal Growth Factor Receptor Peptide exists on the cell surface and is activated by the binding of its specific ligands. EGFR belongs to the tyrosine kinase receptor (RTK) ErbB family. Synonyms: H-Asp-Val-Val-Asp-Ala-Asp-Glu-Tyr-Leu-Ile-Pro-Gln-OH.CH3CO2H; L-alpha-aspartyl-L-valyl-L-valyl-L-alpha-aspartyl-L-alanyl-L-alpha-aspartyl-L-alpha-glutamyl-L-tyrosyl-L-leucyl-L-isoleucyl-L-prolyl-L-glutamine acetic acid; EGF Receptor (985-996) (human) acetate. Grades: ≥95%. Molecular formula: C63H97N13O25. Mole weight: 1436.52. | |
| Epidermal Growth Factor Receptor, phosphorylated (Tyr1045), Positive Control (erbB, EGFR) | Positive control for E3375-53G Epidermal Growth Factor Receptor, phosphorylated (Tyr1045). Group: Molecular Biology. Pack Sizes: 200ul. US Biological Life Sciences. | Worldwide |
| Epidermal Growth Factor Receptor, phosphorylated (Y1068) (erbB, EGFR) | Epidermal Growth Factor Receptor, phosphorylated (Y1068) (erbB, EGFR). Group: Molecular Biology. Grades: Purified. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| α-epidermal growth factor, human | Recombinant human epidermal growth factor has the same structure as the human epidermal growth factor. EGF binds to epidermal growth factor receptor (EGFR) and stimulates cell growth and proliferation. Recombinant human epidermal growth factor is approved for the treatment of diabetic foot ulcers. Uses: The treatment of diabetic foot ulcers. Synonyms: Human EGF; Nepidermin. CAS No. 62253-63-8. Molecular formula: C270H401N73O83S7. Mole weight: 6222. | |
| Anti-Epidermal Growth Factor Receptor antibody produced in goat | affinity isolated antibody, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Epidermal Growth Factor Receptor/Erb B1 antibody produced in goat | affinity isolated antibody, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-phospho-Epidermal Growth Factor Receptor (pTyr845) antibody produced in rabbit | affinity isolated antibody, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-Epidermal Growth Factor antibody produced in mouse | clone EGF-10, purified immunoglobulin, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-phospho-Epidermal Growth Factor Receptor (pTyr1068) antibody produced in mouse | clone 338324, purified immunoglobulin, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Recombinant human epidermal growth factor | rhEGF, human Oligopeptide-1. antirheumatic. CAS No. 62253-63-8. Product ID: 8-01731. Purity: 98% activity 6*105IU/mg. Source : |  |
| 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarbonyl Chloride | 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarbonyl Chloride is used in the synthesis of 6-substituted-4- (3-bromophenylamino) quinazoline derivatives which functions as irreversible inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases. Group: Biochemicals. Grades: Highly Purified. CAS No. 59826-28-7. Pack Sizes: 25mg, 50mg. Molecular Formula: C7H10ClNO, Molecular Weight: 159.61. US Biological Life Sciences. | Worldwide |
| 1-(4-((3-Chloro-4-fluorocyclohexyl)amino)-7-methoxyquinazolin-6-yl)-5-hydroxypyrrolidin-2-one | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Synonyms: 2-Pyrrolidinone, 1-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-5-hydroxy-; Dacomitinib Impurity WYQJ. Grades: ≥95%. CAS No. 2190490-31-2. Molecular formula: C19H16ClFN4O3. Mole weight: 402.81. | |
| 2,3,4-Tri-O-acetyl-6-methyl- β-D-glucopyranuronosyl Genistein Glucuronide Methyl Ester Triacetate | 2,3,4-Tri-O-acetyl-6-methyl- β-D-glucopyranuronosyl Genistein Glucuronide Methyl Ester Triacetate is the protected metabolite of Genistein (G350000) which exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C41H42O23. US Biological Life Sciences. | Worldwide |
| 2-Amino-4,5-bis(2-methoxyethoxy)benzoic Acid Ethyl Ester | 2-Amino-4,5-bis(2-methoxyethoxy)benzoic Acid Ethyl Ester is an intermediate in the synthesis of Erlotinib (E625000, HCl); a selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor and antineoplastic agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 179688-27-8. Pack Sizes: 250mg, 500mg. Molecular Formula: C15H23NO6, Molecular Weight: 313.35. US Biological Life Sciences. | Worldwide |
| 2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Uses: 2-amino-4,5-bis(2-methoxyethoxy)benzonitrile is an impurity of erlotinib (e625008), a egfr-targeted drug in the treatment of non-small cell lung cancer. egfr small tyrosine kinase inhibitor that shows most substantial effect on tumor growth inhibition and animal survival. Synonyms: 2-amino-4,5-bis(2-methoxyethoxy)benzonitrile; 2-amino-4,5-bis(2-methoxyethoxy)benzonitrile. Grades: > 95 %. CAS No. 950596-58-4. Molecular formula: C13H18N2O4. Mole weight: 266.29. | |
| (2E)-N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-butenamide | (2E)-N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-butenamide was used in the study for preparation of disubstituted (arylamino) quinolinecarbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity and antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 848133-88-0. Pack Sizes: 25mg, 100mg. Molecular Formula: C18H19ClN4O2, Molecular Weight: 358.82. US Biological Life Sciences. | Worldwide |
| 2'-Thioadenosine | 2'-Thioadenosine is used as a synthetic intermediate for making a potent and selective erbB-1 (a.k.a. epidermal growth factor receptor) and erbB-2 (a.k.a. neu/her2 growth factor receptor) tyrosine kinase inhibitor. Synonyms: 2'-Thioadenosine; 136904-69-3; CHEMBL14326; (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-sulfanyloxolan-3-ol; thioadenosine; SCHEMBL2699533; DTXSID20435431; 60239-18-1 (non-salt); BDBM50057300; PD138045; J-006937; (2R,3R,4R,5R)-5-(6-Amino-purin-9-yl)-2-hydroxymethyl-4-mercapto-tetrahydro-furan-3-ol; (2R,3R,4R,5R)-5-(6-Amino-9H-purin-9-yl)-2-(hydroxymethyl)-4-mercaptotetrahydrofuran-3-ol. CAS No. 136904-69-3. Molecular formula: C10H13N5O3S. Mole weight: 283.31. | |
| 3-(4-Chloropyrimidin-2-yl)-1-methyl-1H-indole | 3-(4-Chloropyrimidin-2-yl)-1-methyl-1H-indole is an impurity from the synthesis of Osimertinib (A808075), a selective EGFR inhibitor (epidermal growth factor receptor) used in the treatments of nonsmall-cell lung cancer. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg, 250mg. Molecular Formula: C13H10ClN3, Molecular Weight: 243.69. US Biological Life Sciences. | Worldwide |
| 3-Chloro-4-(2-pyridylmethoxy)aniline | 3-Chloro-4-(2-pyridylmethoxy)aniline was used for preparation of disubstituted (arylamino) quinolinecarbonitriles as orally active irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity and antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 524955-09-7. Pack Sizes: 1g, 5g. Molecular Formula: C12H11ClN2O, Molecular Weight: 234.68. US Biological Life Sciences. | Worldwide |
| 3-Ethynylaniline | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Uses: Reagent in the preparation of a metabolite of erlotinib (e625000), which is a selective epidermal growth factor receptor (egfr)-tyrosine kinase inhibitor and an antineoplastic. Synonyms: 3-ethynylaniline. Grades: > 95 %. CAS No. 54060-30-9. Molecular formula: C8H7N. Mole weight: 117.15. | |
| 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline; 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline. Grades: > 95 %. CAS No. 183322-18-1. Molecular formula: C14H17ClN2O4. Mole weight: 312.75. | |
| 4-Methyl Erlotinib Hydrochloride | 4-Methyl Erlotinib Hydrochloride is an impurity of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: N-[(3-Ethynyl-4-methyl)phenyl]-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Hydrochloride. CAS No. 1346601-52-2. Molecular formula: C23H25N3O4. Mole weight: 407.46. | |
| 6,7-Bis(2-methoxyethoxy)quinazolin-4(3H)-one | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 4(3H)-Quinazolinone, 6,7-bis(2-methoxyethoxy)-; 4(1H)-Quinazolinone, 6,7-bis(2-methoxyethoxy)-; 6,7-Bis(2-methoxyethoxy)-4(3H)-quinazolinone; 6,7-Bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one; 6,7-Bis(2-methoxyethoxy)-quinazoline-4(3H)-one; 6,7-Di(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one; CP380736; CP 380736; CP-380736; PF-00520893; PF00520893; PF 00520893. Grades: ≥95%. CAS No. 179688-29-0. Molecular formula: C14H18N2O5. Mole weight: 294.30. | |
| 7-Fluoro-6-nitroquinazolin-4(3H)-one | 7-Fluoro-6-nitroquinazolin-4(3H)-one, is an intermediate in the preparation of kinase inhibitors, such as ATP Site inhibitors of the Tyrosine Kinase activity of the epidermal growth factor receptor. Group: Biochemicals. Alternative Names: 7-Fluoro-4-hydroxy-6-nitroquinazoline; 7-Fluoro-6-nitro-3H-quinazolin-4-one. Grades: Highly Purified. CAS No. 162012-69-3. Pack Sizes: 1g, 5g, 10g, 25g. Molecular Formula: C8H4FN3O3, Molecular Weight: 209.13. US Biological Life Sciences. | Worldwide |
| 8-Gingerol | 8-Gingerol can be found in the rhizome of ginger ( Z. officinale ) and has oral bioactivity. It activates TRPV1 , with an EC 50 value of 5.0 μM. 8-Gingerol inhibits COX-2 and also suppresses the growth of H. pylori in vitro. Additionally, 8-Gingerol exhibits anticancer, antioxidant, and anti-inflammatory properties by inhibiting the epidermal growth factor receptor ( EGFR ) and modulating its downstream STAT3/ERK pathway to suppress the proliferation, migration, and invasion of colorectal cancer cells. 8-Gingerol also exerts immunosuppressive effects by inhibiting oxidative stress, inducing cell cycle arrest, promoting apoptosis , and regulating autophagy. Furthermore, 8-Gingerol has cardioprotective effects. 8-Gingerol is promising for research in the fields of cancer, infection, immunosuppression, and cardiovascular diseases. Uses: Scientific research. Group: Natural products. CAS No. 23513-08-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N0447. |  |
| A431+ EGF (5min) Lysate | A431 cells express approximately 10e6 epidermal growth factor (EGF) receptors at the cell surface. Upon stimulation with EGF, A431 cells exhibit a dramatic increase in phosphorylation of EGF receptors followed by activation of major cell signaling pathways, such as PKB/Akt and MAP kinase pathways. Downstream of these cell signaling pathways, a variety of cytoskeletal, cytoplasmic, and nuclear proteins become phosphorylated at different time points after EGF stimulation. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| A431 EGF Control Lysate | A431 cells express approximately 10e6 epidermal growth factor (EGF) receptors at the cell surface. Upon stimulation with EGF, A431 cells exhibit a dramatic increase in phosphorylation of EGF receptors followed by activation of major cell signaling pathways, such as PKB/Akt and MAP. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| AC480 | AC480, also known as BMS-599626, is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50 =22, 32 and 190 nM, respectively) with potential antineoplastic activity. BMS-599626 inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. Synonyms: BMS-599626; BMS 599626; BMS599626; AC 480; AC-480; Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester; (3S)-3-Morpholinylmethyl N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate; Carbamic acid, [4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester; N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid, (3S)-3-morpholinylmethyl ester. Grades: ≥95%. CAS No. 714971-09-2. Molecular formula: C27H27FN8O3. Mole weight: 530.55. | |
| Actiketal | Actiketal is a glutarimide antibiotic isolated from Streptomyces pulveraceus subsp. epiderstagenes. Actiketal can inhibit the incorporation of [3H] thymidine into Balb/MB cells activated by epidermal growth factor, with IC50 of 14.5 μmol/L, which is stronger than its analog Actiphenol (109.6 μmol/L), but better than epidermal statin (Epiderstatin) 3000 times weaker. CAS No. 133658-47-6. Molecular formula: C15H15NO5. Mole weight: 289.28. | |
| AEE-788 | AEE-788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis. Synonyms: AEE 788; AEE788; 6-[4-[(4-ethylpiperazin-1-yl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine. Grades: >98%. CAS No. 497839-62-0. Molecular formula: C27H32N6. Mole weight: 440.595. | |
| AG 126 | Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK (growth factor receptor kinases). AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α (tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG 126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM. AG 126 may represent a new approach for the therapy of inflammation. Uses: Anti- inflammation. Synonyms: AG126; AG-126; Tyrphostin AG 126; UNII-7YA4AMD1JC; Tyrphostin A 10; alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile. Grades: 95%. CAS No. 118409-62-4. Molecular formula: C10H5N3O3. Mole weight: 215.16. | |
| AG 1478 - CAS 175178-82-2 | A cell-permeable, reversible, ATP-competitive, highly potent and selective inhibitor of epidermal growth factor receptor kinase versus HER2-neu and platelet-derived growth factor receptor kinase. Group: Fluorescence/luminescence spectroscopy. | |
| AG 1478 hydrochloride | The hydrochloride salt form of AG 1478, which has been found to be an epidermal growth factor receptor tyrosine kinase inhibitor. Synonyms: AG 1478 hydrochloride; AG1478 hydrochloride; AG-1478 hydrochloride; N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinanine hydrochloride. Grades: ≥98% by HPLC. CAS No. 170449-18-0. Molecular formula: C16H14ClN3O2.HCl. Mole weight: 352.22. | |
| AG-1557 | AG-1557 is an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. Synonyms: AG-1557; AG 1557; AG1557; N-(3-Iodophenyl)-6,7-dimethoxyquinazolin-4-amine. CAS No. 189290-58-2. Molecular formula: C16H14IN3O2. Mole weight: 407.211. | |
| AG-1557 hydrochloride | AG-1557 hydrochloride is a specific and ATP competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. Synonyms: AG 1557 hydrochloride; AG1557 hydrochloride. Molecular formula: C16H15ClIN3O2. Mole weight: 443.66. | |
| AG-183 | AG-183 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 0.8 μM in the human epidermoid carcinoma cell line A431. Synonyms: Tyrphostin 51; Tyrphostin AG 183. Grades: ≥98%. CAS No. 122520-90-5. Molecular formula: C13H8N4O3. Mole weight: 268.2. | |
| AG-213 | AG-213 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 2.4 μM in the human epidermoid carcinoma cell line A431. Uses: Enzyme inhibitors. Synonyms: Tyrphostin AG-213; Tyrphostin 47; (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethioamide. Grades: ≥97%. CAS No. 122520-86-9. Molecular formula: C10H8N2O2S. Mole weight: 220.2. | |
| AG 490 - CAS 133550-30-8 | A cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC?? = 100 nM). Group: Fluorescence/luminescence spectroscopy. | |
| AG 494 | AG-494 is a EGFR (epidermal growth factor receptor) kinase inhibitor with IC50 value of 0.7 μM. It is selective over ErbB2, PDGFR and insulin receptor kinase (IC50 values are 42, 6 and > 100 μM respectively). AG-494 tyrphostin also can block Cdk2 activation. Synonyms: alpha-Cyano-(3,4-dihydroxy)-N-phenylcinnamide; Tyrphostin AG-494; Tyrphostin B48. Grades: 98%. CAS No. 139087-53-9. Molecular formula: C16H12N2O3. Mole weight: 280.28. | |
| AG 555 | AG 555 is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (IC50 = 0.7 μM) with 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Synonyms: AG 555; AG-555; AG555; (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)prop-2-enamide; AG 555; AG-555; alpha-cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamide; N-(3'-Phenylpropyl)-3,4-dihydroxybenzylidenecyanoacetamide; N-(3-phenylpropyl)-3,4-dihydroxybenzylidene cyanoacetamide; tyrphostin AG 555; tyrphostin AG-555; tyrphostin B46. Grades: ≥98% (HPLC). CAS No. 133550-34-2. Molecular formula: C19H18N2O3. Mole weight: 322.36. | |
| AG-82 | AG-82 is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 3 μM in the human epidermoid carcinoma cell line A431. Uses: Antineoplastic agents. Synonyms: NSC 676484; RG-50875; Tyrphostin 25; Tyrphostin AG-82. Grades: ≥95%. CAS No. 118409-58-8. Molecular formula: C10H6N2O3. Mole weight: 202.2. | |
| AP-26113 | AP26113 is an orally available inhibitor of receptor tyrosine kinases anaplastic lymphoma kinase (ALK) and the epidermal growth factor receptor (EGFR) with potential antineoplastic activity. AP26113 binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. AP26113 appears to overcome mutation-based resistance. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. Synonyms: AP-26113; AP 26113; AP26113; (2-((5-chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide; AP26113-analog; AP-26113-analog; AP 26113-analog, Brigatinib-analog. Grades: 0.98. CAS No. 1197958-12-5. Molecular formula: C26H34ClN6O2P. Mole weight: 529.01. | |
| AST-1306 | AST-1306 is a selective irreversible inhibitor of the epidermal growth factor receptor (EGFR) 1 and 2. Studies show that AST-1306 inhibited the enzymatic activities of wild-type EGF) and ErbB2 as well as EGFR resistant mutant in both cell-free and cell-based systems. AST-1306 was more effective in inhibiting tumors with ErbB2-overexpressing cells than EGFR-overexpressing tumor. Group: Biochemicals. Alternative Names: N- [4- [ [3-Chloro-4- [ (3-fluorobenzyl) oxy] phenyl] amino] quinazolin-6-yl] acrylamide; N-[4-[[3-Chloro-4-[ (3-fluorophenyl) methoxy]phenyl]amino]-6-quinazolinyl]-2-propenamide; ALS1306; AST 1306; AST 6. Grades: Highly Purified. CAS No. 897383-62-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Asterriquinone SU5228 | Asterriquinone SU5228 is a quinone compounds containing indole produced by Aspergillus candidus. It has the effect of inhibiting the binding of Grb-2 adaptor (Adapter) to phosphorylated epidermal growth factor (EGF) receptor tyrosine kinase. Molecular formula: C27H22N2O4. Mole weight: 438.47. | |
| Asterriquinone SU5500 | Asterriquinone SU5500 is a quinone compounds containing indole produced by Aspergillus candidus. It has the effect of inhibiting the binding of Grb-2 adaptor (Adapter) to phosphorylated epidermal growth factor (EGF) receptor tyrosine kinase. Synonyms: 2,5-Bis[2-(3-methyl-2-butenyl)-1H-indole-3-yl]-3-acetoxy-6-hydroxy-1,4-benzoquinone. Molecular formula: C34H32N2O5. Mole weight: 548.64. | |
| AV-412 | AV-412 is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may suppress tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization. Synonyms: AV 412; AV412; N-[4-(3-chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide. CAS No. 451492-95-8. Molecular formula: C27H28ClFN6O. Mole weight: 507.01. | |
| Avitinib | Avitinib (AC0010) is a third generation inhibitor of the EGFR (epidermal growth factor receptor) that was permitted parallel phase I clinical trials in the US. It is a pyrrolopyrimidine-based irreversible EGFR inhibitor that is mutation-selective with IC50 value of 0.18 nM against EGFR L858R/T790M double mutations. Upon oral administration, avitinib covalently binds to and inhibits the activity of mutant forms of EGFR. Uses: Tyrosine kinase inhibitors. Synonyms: AC0010. Grades: ≥98%. CAS No. 1557267-42-1. Molecular formula: C26H26FN7O2. Mole weight: 487.5. | |
| Avitinib maleate | Avitinib maleate, the maleate salt form of avitinib, is a pyrrolopyrimidine-based, irreversible epidermal growth factor receptor (EGFR) mutant-selective inhibitor (IC50 = 7.68 nM), with potential antineoplastic activity. Uses: Tyrosine kinase inhibitors. Synonyms: Avitinib maleate; AC0010MA; AC-0010MA; AC 0010MA; AC0010; AC-0010; AC 0010. CAS No. 1557268-88-8. Molecular formula: C30H30FN7O6. Mole weight: 603.6. | |
| AZD3759 | AZD3759 is a n orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, AZD3759 binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. Synonyms: AZD3759; AZD-3759; AZD 3759. Grades: 98%. CAS No. 1626387-80-1. Molecular formula: C22H23ClFN5O3. Mole weight: 459.91. | |
| AZD-9291 | AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. AZD 9291 is an irreversible inhibitor of epidermal growth factor receptor (EGFR) sensitizing and T790M resistance mutations (IC50s = 15-17 nM) while sparing the wild-type form of the receptor (IC50 = 480 nM). It binds the related IGF1R and hERG receptors with significantly reduced potency (IC50s = 2.9 and 16.2 μM, respectively). Uses: For research used only. Synonyms: Mereletinib; EGFR inhibitor; AZD9291; AZD 9291. Grades: 98%. CAS No. 1421373-65-0. Molecular formula: C28H33N7O2. Mole weight: 499.61. | |
| BE-23372M | BE-23372M is a protein tyrosine kinase inhibitor produced by Rhizoctonia solani. It has strong inhibition of epidermal growth factor (EGF) receptor kinase activity. Synonyms: (3E)-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl)furan-2(3H)-one. CAS No. 145588-13-2. Molecular formula: C17H12O6. Mole weight: 312.27. | |
| BGB-283 | BGB-283 is a selective Epidermal growth factor receptor and Proto oncogene protein b raf inhibitor under the development of BeiGene. BGB-283 shows antitumor activity in B-RAF Mutated Colorectal Cancers. In vitro, BGB-283 can inhibit B-RAFV600E-activated ERK phosphorylation and cell proliferation. In vivo, BGB-283 can lead to dose-dependent tumor growth inhibition accompanied by partial and complete tumor regressions in both cell-line derived and primary human colorectal tumor xenografts bearing B-RAFV600E mutation. Phase I clinical trials for the treatment of solid tumours are on-going. Uses: Solid tumours. Synonyms: UNII-8762XZS5ZF; 8762XZS5ZF; BGB-283; BGB 283; BGB283; Beigene-283; Beigene283; Beigene 283; Lifirafenib; Compound 2.2b; Beigene-283; GTPL8958;5-[[(1R,1aS,6bR)-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one. Grades: 98%. CAS No. 1446090-77-2. Molecular formula: C25H17F3N4O3. Mole weight: 478.31. | |
| BIBU 1361 dihydrochloride | BIBU 1361 dihydrochloride is an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM) with ~ 100-fold lower potency than ErbB2 (IC50 = 290 nM) and selectivity over a range of other related tyrosine kinases (IC50 > 10 μM). BIBU 1361 blocks downstream EGFR signaling events such as MAPKK/MAPK activation. Synonyms: BIBU 1361 dihydrochloride; BIBU1361 dihydrochloride; BIBU-1361 dihydrochloride; N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-pyrimido[5,4-d]pyrimidin-4-amine dihydrochloride. Grades: ≥97% by HPLC. CAS No. 793726-84-8. Molecular formula: C22H27ClFN7.2HCl. Mole weight: 516.87. | |
| BIBX 1382 dihydrochloride | BIBX 1382 dihydrochloride is a potent and selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM) with > 1000-fold lower potency than ErbB2 (IC50 = 3.4 μM) and a range of other related tyrosine kinases (IC50 > 10 μM). BIBX 1382 inhibits Lassa, Ebola and Marburg viruses. Synonyms: BIBX 1382 dihydrochloride; BIBX1382 dihydrochloride; BIBX-1382 dihydrochloride; Falnidamol Dihydrochloride; N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diamine dihydrochloride. Grades: ≥97% by HPLC. CAS No. 1216920-18-1. Molecular formula: C18H19ClFN7.2HCl. Mole weight: 460.77. | |
| BLU-945 | BLU-945 is a potent, highly selective, reversible and orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKIs). BLU-945 can effectively inhibit EGFR with L858R and/or exon 19 deletion mutation, T790M mutation and C797S mutation. BLU-945 can be used for the research of lung cancer including non-small cell lung cancer (NSCLC) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ZL-2313. CAS No. 2660250-10-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-144680. | |
| BMS-599626 Hydrochloride | BMS-599626 Hydrochloride is a selective and efficacious orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases with potential antineoplastic activity. It inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. Synonyms: AC480 hydrochloride; AC 480 hydrochloride; AC-480 hydrochloride; BMS-599626 HCl; BMS-599626 monohydrochloride; BMS 599626 Hydrochloride; BMS599626 hydrochloride; Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester, hydrochloride (1:1); Carbamic acid, [4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester, monohydrochloride; (S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)imino)-5-methyl-1,4-dihydropyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate hydrochloride. Grades: >98%. CAS No. 873837-23-1. Molecular formula: C27H28ClFN8O3. Mole weight: 567.01. | |
| BMS-6690514 | BMS-690514 is a potent inhibitor of human epidermal growth factor receptor (HER) 1 (EGFR), 2, and 4, and vascular endothelial growth factor receptors (VEGFR) 1-3. BMS-690514 is currently under investigation as an oral agent for the treatment of solid tumors. The preclinical ADME properties of BMS-690514 suggest good oral bioavailability in humans and metabolism by multiple pathways including oxidation and glucuronidation. Synonyms: BMS-6690514; BMS 6690514; BMS6690514. Grades: 0.98. CAS No. 859853-30-8. Molecular formula: C19H24N6O2. Mole weight: 368.441. | |
| Bovine factor IX | The zymogen factor IX is a single chain vitamin K-dependent glycoprotein which is synthesized in the liver. The domain structure of factor IX is similar to that of the other vitamin K dependent coagulation factors. The NH2-terminal region contains 12 γ-carboxyglutamic acid (gla) residues which facilitate the calcium dependent binding of factor IX to negatively charged phospholipid surfaces. Two domains which are homologous to epidermal growth factor (EGF) span the region between the NH2-terminal gla domain and the activation peptide (Ala-146 to Arg-180).Factor IX is activated by either factor XIa or the factor VIIa/tissue factor/phospholipid complex. Cleavage at site A (see fig... activates factor X to factor Xa.Human factor IX is prepared from fresh frozen plasma by a combination of conventional procedures and immunoaffinity chromatography. Bovine factor IX is prepared from fresh citrated bovine plasma by a modification of the method described by Fujikawa et al. The purified proteins are supplied in 50% (vol/vol) glycerol/H2O and should be stored at -20°C. Purity is determined by SDS-PAGE analysis and activity is measured using a factor IX clotting assay. Group: Zymogens. CAS No. 9001-28-9. Purity: >95% by SDS-PAGE. Factor IX. Mole weight: 55400. Stability: 12 months. Storage: -20°C. Source: Bovine. Bovine factor IX; Factor IX. Pack: 100 ug. Cat No: CZY-003. |  |
| Bovine Factor X | Factor X is a vitamin K-dependent protein zymogen which is synthesized in the liver and circulates in plasma as a two chain molecule linked by a disulfide bond. Prior to secretion into plasma, post-translational modifications produce 11 gamma-carboxyglutamic acid (gla) residues and a single b-hydroxyaspartic acid residue, which are located within the NH2-terminal light chain. The light chain also contains two epidermal growth factor (EGF) homology domains. The COOH-terminal heavy chain of factor X contains most of the carbohydrate moieties, as well as the latent serine protease domain. The activation of factor X is catalyzed by either the intrinsic factor Xase complex (factor IXa, fa...y of the prothrombinase complex. The first EGF homology domain contains a Ca2+ binding site which acts as a hinge to fold the EGF and GLA domains towards each other. This region of the molecule is involved in the recognition of cellular binding domains.Human factor X is isolated from fresh frozen human plasma by a combination of conventional techniques and immunoaffinity chromatography. In addition to the standard human factor X preparation, Gla-domainless human factor X is also available. Bovine factor X is isolated from fresh bovine plasma using a modification of the procedure reported by Bajaj et al. The purified zymogen is supplied in 50% (vol/vol) glycerol/H2O and should be store | |
| Bovine Protein C | The vitamin K-dependent zymogen, protein C, is synthesized in the liver as a single chain polypeptide and is subsequently converted to a disulfide linked heterodimer, by removal of a dipeptide (Lys-146 and Arg-147) from the precursor molecule. Trace quantities of the single chain form have been observed in plasma. The light chain, which is responsible for the calcium dependent binding of protein C to phospholipid vesicles, contains 11 γ-carboxyglutamic acid (gla) residues, 1 b-hydroxyaspartic acid residue, and 2 epidermal growth factor (EGF) homology domains. The serine protease catalytic triad is located in the heavy chain. Human protein C is susceptible to proteolytic cleavag...g the proteolytic inactivation of factors Va and VIIIa. APC also contributes to the fibrinolytic response by complex formation with plasminogen activator inhibitors.Bovine protein C is prepared from fresh citrated bovine plasma by a modification of the Walker procedure, as described by Haley et al. Human protein C is prepared from fresh frozen citrated human plasma using a combination of immunoaffinity chromatography, and conventional techniques. Protein C is provided in 50% (vol/vol) glycerol/H2O and should be stored at -20°C. Purity is determined by SDS-PAGE analysis and activity is measured using a chromogenic substrate based assay. Group: Zymogens. Purity: >95% by SDS-PAGE. Prote | |
| BPIQ-I | BPIQ-I is an extremely potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) with IC50 of 25 pM. It can inhibit the growth of SKOV3 and MDA-468 tumor cell lines with EC50 values of 6.5 and 30 μM, respectively. Uses: Protein kinase inhibitors. Synonyms: PD 159121. Grades: ≥95%. CAS No. 174709-30-9. Molecular formula: C16H12BrN5. Mole weight: 354.2. | |
| BPIQ-II hydrochloride | BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) with IC50 of 8 pM. It is selective for EGFR over an assortment of other tyrosine and serine/threonine kinases. Cellular studies indicate that BPIQ-II can enter cells and very selectively shut down EGF-stimulated signal transmission by binding competitively at the ATP site of EGFR. Synonyms: PD 158294. Grades: ≥98%. CAS No. 171179-37-6. Molecular formula: C15H10BrN5·HCl. Mole weight: 376.6. | |
| Canertinib dihydrochloride | Canertinib dihydrochloride is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities. Canertinib binds to the intracellular domains of epidermal growth factor receptor tyrosine kinases (ErbB family), irreversibly inhibiting their signal transduction functions and resulting in tumor cell apoptosis and suppression of tumor cell proliferation. This agent also acts as a radiosensitizing agent and displays synergistic activity with other chemotherapeutic agents. Uses: Antineoplastic agents. Synonyms: N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(3-(morpholin-4-yl)propoxy)quinazolin-6-yl)prop-2-enamide; CI1033PD183805. Grades: ≥98% (HPLC). CAS No. 289499-45-2. Molecular formula: C24H27Cl3FN5O3. Mole weight: 558.86. | |
| Cetuximab | Cetuximab (C225) is a human IgG1 monoclonal antibody that inhibits epidermal growth factor receptor ( EGFR ), with a K d of 0.201 nM for EGFR by SPR. Cetuximab has potent antitumor activity [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: C225. CAS No. 205923-56-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P9905. | |
| Cetuximab | Cetuximab is a remarkable monoclonal antibody widely employed in the research of epidermal growth factor receptor (EGFR). Synonyms: N-(2-phenylethoxy)-1-pyridin-4-ylmethanimine; MLS002608064; AC1L5VKQ; CHEMBL1736329; MolPort-001-793-950; HMS3092B19. Grades: 95%. CAS No. 205923-56-4. Molecular formula: C14H14N2O. Mole weight: 226.274. | |
| CGP52411 | CGP52411, also known as DAPH, is a selective inhibitor of the epidermal growth factor receptor (EGFR). It is also inhibits and reverses the formation of Aβ42 fibers associated with Alzheimer's disease. It may offer therapeutic agents for the treatment of hyperproliferative diseases. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CGP52411; CGP 52411; CGP-52411; DAPH. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 145915-58-8. Molecular formula: C20H15N3O2. Mole weight: 329.36. Purity: >98%. IUPACName: 5,6-bis(phenylamino)isoindoline-1,3-dione. Canonical SMILES: O=C1NC(C2=CC(NC3=CC=CC=C3)=C(C=C21)NC4=CC=CC=C4)=O. Product ID: ACM145915588-1. Alfa Chemistry ISO 9001:2015 Certified. Categories: 4,5-dianilinophthalimide. |  |
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