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1-(2-Fluoroethyl)-4-hydroxypiperidine. Group: Biochemicals. Grades: Highly Purified. CAS No. 492446-45-4. Pack Sizes: 25mg, 50mg. Molecular Formula: C7H14FNO, Molecular Weight: 147.19. US Biological Life Sciences.
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1-Bromo-5-fluoroethylbenzene
1-Bromo-5-fluoroethylbenzene. Group: Biochemicals. Alternative Names: 1-Bromo-2-ethyl-4-fluorobenzene. Grades: Highly Purified. Pack Sizes: 500mg. Molecular Formula: C8H8BrF, Molecular Weight: 203.05. US Biological Life Sciences.
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2,2,2-Trifluoroethyl perfluorobutane sulphonate
2,2,2-Trifluoroethyl perfluorobutane sulphonate is a useful organic reagent for fluorination, fluoroethylation and other reactions for organic synthesis. Also used as a reagent in the synthesis of heterocyclic amide derivatives as RXR agonist for the treatment of diseases like diabetes, dyslipidemia, hypercholesterolemia and others. Group: Biochemicals. Grades: Highly Purified. CAS No. 79963-95-4. Pack Sizes: 1g, 5g. Molecular Formula: C6H2F12O3S, Molecular Weight: 382.12. US Biological Life Sciences.
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2,3-trans-3-((4-Amino-6-(1-fluoroethyl)-1,3,5-triazin-2-yl)amino)-5-(hydroxymethyl)-2-methyl-2,3-dihydro-1H-inden-1-one (Mixture of Diastereomers)
2,3-trans-3-((4-Amino-6-(1-fluoroethyl)-1,3,5-triazin-2-yl)amino)-5-(hydroxymethyl)-2-methyl-2,3-dihydro-1H-inden-1-one (Mixture of Diastereomers) is a metabolite of the herbicide Indaziflam (950782-86-2). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C16H18FN5O2; x(HCl), Molecular Weight: 331.34. US Biological Life Sciences.
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2,3-trans-3-((4-Amino-6-(1-fluoroethyl-D4)-1,3,5-triazin-2-yl)amino)-5-(hydroxymethyl)-2-methyl-2,3-dihydro-1H-inden-1-one (Mixture of Diastereomers)
2,3-trans-3-((4-Amino-6-(1-fluoroethyl-D4)-1,3,5-triazin-2-yl)amino)-5-(hydroxymethyl)-2-methyl-2,3-dihydro-1H-inden-1-one (Mixture of Diastereomers) is a labeled metabolite of the herbicide Indaziflam (950782-86-2). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C16H14D4FN5O2; x(HCl), Molecular Weight: 335.37. US Biological Life Sciences.
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2-cis,3-trans-3-((4-Amino-6-(1-fluoroethyl)-1,3,5-triazin-2-yl)amino)-2,5-dimethyl-2,3-dihydro-1H-inden-1-ol (Mixture of Diastereomers)
2-cis,3-trans-3-((4-Amino-6-(1-fluoroethyl)-1,3,5-triazin-2-yl)amino)-2,5-dimethyl-2,3-dihydro-1H-inden-1-ol (Mixture of Diastereomers) is a metabolite of the herbicide Indaziflam (950782-86-2). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C16H20FN5O, Molecular Weight: 317.36. US Biological Life Sciences.
Worldwide
2-cis,3-trans-3-((4-Amino-6-(1-fluoroethyl-D4)-1,3,5-triazin-2-yl)amino)-2,5-dimethyl-2,3-dihydro-1H-inden-1-ol (Mixture of Diastereomers)
2-cis,3-trans-3-((4-Amino-6-(1-fluoroethyl-D4)-1,3,5-triazin-2-yl)amino)-2,5-dimethyl-2,3-dihydro-1H-inden-1-ol (Mixture of Diastereomers) is a labeled metabolite of the herbicide Indaziflam (950782-86-2). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C16H16D4FN5O, Molecular Weight: 321.39. US Biological Life Sciences.
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2-Fluoroethyl 4-methylbenzenesulfonate
2-Fluoroethyl 4-methylbenzenesulfonate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Fluoroethylp-tosylate;FLUOROETHYL 4-TOLUENESULFONATE;2-FLUOROETHYL TOSYLATE;2-Fluoro-(4-methylbenzenesulfonate)ethanol;L-TRYPTOPHAN/D-TRYPTOPHAN;2-fluoroethyl 4-methylbenzenesulfonate;Fluoroethyl p-toluenesulfonate. Product Category: Heterocyclic Organic Compound. CAS No. 383-50-6. Molecular formula: C9H11FO3S. Mole weight: 218.25. Density: 1.241 g/cm³. Product ID: ACM383506. Alfa Chemistry ISO 9001:2015 Certified. Categories: 2-fluoroethyl p-toluenesulfonate.
2-Fluoroethyl a-L-fucopyranoside
2-Fluoroethyl a-L-fucopyranoside is an esteemed compound, serving as a veritable foundation for enzymatic glycosylation reactions in carbohydrate-derived pharmaceutical synthesis. Molecular formula: C8H15FO5. Mole weight: 210.20.
2-Fluoroethylamine, HCl
2-Fluoroethylamine, HCl. Group: Biochemicals. Grades: Highly Purified. CAS No. 460-08-2. Pack Sizes: 100mg, 250mg. Molecular Formula: C2H7ClFN, Molecular Weight: 99.54. US Biological Life Sciences.
2-Fluoroethyl Carbonochloridate is an intermediate used to prepare selective MMP-12 inhibitors for use in COPD treatment. It is also used in the synthesis of potent and selective nonpeptide antagonist of melanocortin-4 receptor. Group: Biochemicals. Grades: Highly Purified. CAS No. 462-27-1. Pack Sizes: 1g, 5g. Molecular Formula: C3H4ClFO2, Molecular Weight: 126.51. US Biological Life Sciences.
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2-Fluoroethyl chloroformate
2-Fluoroethyl chloroformate. Uses: Designed for use in research and industrial production. Product Category: Alkyl Fluorinated Building Blocks. CAS No. 462-27-1. Molecular formula: C3BrF5O. Mole weight: 126.51. Product ID: ACM462271. Alfa Chemistry ISO 9001:2015 Certified.
2-Fluoroethyl tosylate
2-Fluoroethyl tosylate. Group: Biochemicals. Grades: Highly Purified. CAS No. 383-50-6. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. Molecular Formula: C9H11FO3S. US Biological Life Sciences.
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(±)-2-Methyl Arachidonoyl-2'-Fluoroethylamide
(±)-2-Methyl arachidonoyl-2'-fluoroethylamide (2-Methyl-2'-fluoro AEA) is an analog of anandamide (AEA) in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom. An analog of arachidonylethanolamide that is a strong, selective CB1 cannabinoid receptor agonist. Synonyms: 2-methyl-2'-fluoro AEA; 2-Methyl-2'-fluoro Anandamide; O-689; (A+/-)-2-Methylarachidonoyl-2'-fluoroethylamide N-(2-fluoroethyl)-2-methylicosa-5,8,11,14-tetraenamide. Grades: ≥95%. CAS No. 166100-39-6. Molecular formula: C23H38FNO. Mole weight: 363.6.
A deoxyuridine derivative as radiotracer for monitoring cancer gene therapy with PET. Synonyms: 2'-Deoxy-5-(2-fluoroethyl)uridine. CAS No. 108008-61-3. Molecular formula: C11H15FN2O5. Mole weight: 274.25.
Arachidonoyl-2'-fluoroethylamide
Arachidonoyl-2'-fluoroethylamide (2-fluoro AEA) is an analog of anandamide in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom. Arachidonoyl 2'-fluoroethylamide is a CB1 receptor agonist with Ki of 26.7 nM for CB1 and Ki of 908 nM for CB2. The in vivo activity of 2-fluoro AEA is enhanced much less than the binding affinity, because the analog remains a good substrate for FAAH. Synonyms: 2'-fluoro AEA; 2'-fluoro Anandamide. Grades: ≥98%. CAS No. 166100-37-4. Molecular formula: C22H36FNO. Mole weight: 349.5.
Benzenamine,N,N-bis(2-fluoroethyl)-3-methyl-
Benzenamine,N,N-bis(2-fluoroethyl)-3-methyl-. Uses: Designed for use in research and industrial production. Additional or Alternative Names: NCIOpen2_001081, NSC82275, CID256047, 13452-69-2. Product Category: Heterocyclic Organic Compound. CAS No. 13452-69-2. Molecular formula: C11H15F2N. Mole weight: 199.2403. Purity: 0.96. IUPACName: N,N-bis(2-fluoroethyl)-3-methylaniline. Density: 1.061g/cm³. Product ID: ACM13452692. Alfa Chemistry ISO 9001:2015 Certified.
Poly(difluoromethylene). alpha.-chloro-.omega.-(1-chloro-1-fluoroethyl)-. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Poly(difluoromethylene). alpha.-chloro-.omega.-(1-chloro-1-fluoroethyl)-;ALPHA-CHLORO-OMEGA-(1-CHLORO-1-FLUOROETHYL)-POLY-TFE;poly-TFE, alpha-chloro-omega-1-(1-chloro-1-fluoroethyl)-. Product Category: Heterocyclic Organic Compound. CAS No. 131324-06-6. Product ID: ACM131324066. Alfa Chemistry ISO 9001:2015 Certified.
1-Bromo-4-(1-fluoro-ethyl)-benzene
1-Bromo-4-(1-fluoro-ethyl)-benzene. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-Bromo-4-(1-fluoro-ethyl)-benzene. Product Category: Heterocyclic Organic Compound. CAS No. 159298-87-0. Product ID: ACM159298870. Alfa Chemistry ISO 9001:2015 Certified. Categories: 1-bromo-4-(1-fluoroethyl)benzene.
1-ETHYL-4-FLUOROBENZENE
1-ETHYL-4-FLUOROBENZENE. Uses: Designed for use in research and industrial production. Additional or Alternative Names: p-Ethylfluorobenzene, p-Fluoroethylbenzene, p-Ethyl fluorobenzene, CID136303, 459-47-2. Product Category: Heterocyclic Organic Compound. Appearance: liquid. CAS No. 459-47-2. Molecular formula: C8H9F. Mole weight: 124.16. Purity: 0.96. IUPACName: 1-ethyl-4-fluorobenzene. Canonical SMILES: CCC1=CC=C(C=C1)F. Product ID: ACM459472. Alfa Chemistry ISO 9001:2015 Certified.
1-Fluoro-2-iodoethane
1-Fluoro-2-iodoethane. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-fluor-2-jodethan;1-fluoro-2-iodo-ethan;2-fluoroethyliodide;2-FLUORO-1-IODOETHANE;1-IODO-2-FLUOROETHANE;1-FLUORO-2-IODOETHANE;1-Fluoro-2-iodoethane98%;2-Fluoro-1-iodoethane, 2-Iodoethyl fluoride, 2-Fluoroethyl iodide. Product Category: Heterocyclic Organic Compound. CAS No. 762-51-6. Molecular formula: C2H4FI. Mole weight: 173.96. Product ID: ACM762516. Alfa Chemistry ISO 9001:2015 Certified.
2,?2,?3,?3,?3-?Pentafluoropropanoic Acid
Pentafluoropropionic acid (Perfluoropropionic acid) was used in the analysis of gentamicin with Gemini column by liquid chromatographic (LC) methods. It was also used to prepare [ (R) - (amino) (oxo) (fluorophenyl) butyl]tetrahydro (fluoroethyl) -1, 2, 4-triazolo[4, 3-a]pyrazine using (fluoro)propanoic acid. Group: Biochemicals. Grades: Highly Purified. CAS No. 422-64-0. Pack Sizes: 1g, 10g. Molecular Formula: C3HF5O2. US Biological Life Sciences.
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2,?2,?3,?3,?3-?Pentafluoropropanoic Acid-13C
2,?2,?3,?3,?3-?Pentafluoropropanoic Acid-13C is the labeled analogue of 2,?2,?3,?3,?3-?Pentafluoropropanoic Acid (P227235), which is used in the analysis of gentamicin with Gemini column by liquid chromatographic (LC) methods. It was also used to prepare [ (R) - (amino) (oxo) (fluorophenyl) butyl]tetrahydro (fluoroethyl) -1, 2, 4-triazolo[4, 3-a]pyrazine using (fluoro)propanoic acid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 100mg. Molecular Formula: C213CHF5O2, Molecular Weight: 165.02. US Biological Life Sciences.
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2-(2-Fluoroethoxy)naphthalene
2-(2-Fluoroethoxy)naphthalene. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-(2-Fluoroethoxy)naphthalene, 2-Fluoroethyl 2-naphthyl ether, 2-Naphthyl 2-fluoroethyl ether, Ether, 2-fluoroethyl 2-naphthyl, 2-Fluoroethyl beta-naphthyl ether, BRN 3242270, NAPHTHALENE, 2-(2-FLUOROETHOXY)-, 325-24-6, AC1L1T3J, LS-94703, 4-06-00-04258 (Beilstein Handbook Reference). Product Category: Heterocyclic Organic Compound. CAS No. 325-24-6. Molecular formula: C12H11FO. Mole weight: 190.214 g/mol. Purity: 0.96. IUPACName: 2-(2-fluoroethoxy)naphthalene. Canonical SMILES: C1=CC=C2C=C(C=CC2=C1)OCCF. Product ID: ACM325246. Alfa Chemistry ISO 9001:2015 Certified.
2-Fe-beta-cit
2-Fe-beta-cit. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-(4-IODO-PHENYL)-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID 2-FLUORO-ETHYL ESTER;2-FE-BETA-CIT;2-FLUORETHYL;2-FLUORETHYL-BETA-CIT;8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, 3-(4-IODOPHENYL)-8-METHYL-, 2-FLUOROETHYL ESTER, (1R,2S,3S,5S)-;3be. Product Category: Heterocyclic Organic Compound. CAS No. 398497-81-9. Molecular formula: C17H21FINO2. Mole weight: 417.26. Product ID: ACM398497819. Alfa Chemistry ISO 9001:2015 Certified.
Acorafloxacin free base
Acorafloxacin, also known as Avarofloxacin, JNJ-Q2 and JNJ-32729463, is a broad-spectrum fluoroquinolone antibacterial drug being developed for the treatment of acute bacterial skin and skin-structure infections and community-acquired pneumonia. Specifically, JNJ-Q2 is being actively studied for treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. Uses: Designed for use in research and industrial production. Additional or Alternative Names: JNJ-32729463; JNJ 32729463; JNJ32729463; JNJ-32729463-AAA; JNJ32729463-AAA; JNJ 32729463-AAA; JNJ-Q2; Acorafloxacin; Avarofloxacin. Product Category: Others. Appearance: Solid powder. CAS No. 878592-87-1. Molecular formula: C21H23F2N3O4. Mole weight: 419.43. Purity: >98%. IUPACName: (E)-7-(3-(2-amino-1-fluoroethylidene)piperidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid. Canonical SMILES: O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4C/C(CCC4)=C(F)\CN)=C3OC)C1=O)O. Product ID: ACM878592871. Alfa Chemistry ISO 9001:2015 Certified.
Avarofloxacin hydrochloride
Avarofloxacin hydrochloride is an antibacterial drug agent. Uses: Avarofloxacin hydrochloride is an antibacterial drug agent. Synonyms: Avarofloxacin HCl;JNJ-Q2 hydrochloride;7-[(3E)-3-(2-amino-1-fluoroethylidene)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid hydrochloride;JNJ-32729463 hydrochloride;JNJ 32729463 hydrochloride. Grades: >98 %. CAS No. 1001162-01-1. Molecular formula: C21H24ClF2N3O4. Mole weight: 455.89.
Bis-(2-fluoro-2,2-dinitroethoxy)methane
Bis-(2-fluoro-2,2-dinitroethoxy)methane. Uses: Designed for use in research and industrial production. Additional or Alternative Names: FEFO, Bis(2,2-dinitro-2-fluoroethyl)formal, Bis(2-fluoro-2,2-dinitroethyl)formal, EINECS 241-081-4, Bis(2-fluoro-2,2-dinitroethoxy)methane, NSC 312448, CID86900, Methane, bis(2-fluoro-2,2-dinitroethoxy)-, NSC312448, LS-65578, Formaldehyde bis(2-fluoro-2,2-dinitroethyl) acetal, Ethane, 1,1-(methylenebis(oxy))bis(2-fluoro-2,2-dinitro-, Ethane, 1,1-[methylenebis(oxy)]bis[2-fluoro-2,2-dinitro-, 1,1-Dinitro-2-(2,2-dinitro-ethoxy)methoxy)-1-fluoro-ethane, 17003-79-1. Product Category: Heterocyclic Organic Compound. CAS No. 17003-79-1. Molecular formula: C5H6F2N4O10. Mole weight: 320.119 g/mol. Purity: 0.96. IUPACName: 1-fluoro-2-[(2-fluoro-2,2-dinitroethoxy)methoxy]-1,1-dinitroethane. Canonical SMILES: C(C([N+](=O)[O-])([N+](=O)[O-])F)OCOCC([N+](=O)[O-])([N+](=O)[O-])F. Density: 1.721g/cm³. ECNumber: 241-081-4. Product ID: ACM17003791. Alfa Chemistry ISO 9001:2015 Certified. Categories: bis(fluorodinitroethyl)dimethoxymethane.
CB 3731
CB 3731 can be used in fluorine-19 nuclear magnetic resonance studies of binary and ternary complexes of thymidylate synthase. Synonyms: CB 3731; CB-3731; CB3731. N-(4-((N-(2-Amino-4-hydroxy-6-quinazolinyl)methyl)-N-(fluoroethyl)amino)benzoyl)glutamic acid. Grades: 98%. CAS No. 80015-07-2. Molecular formula: C23H24FN5O6. Mole weight: 458.47.
CNX-2006
CNX-2006 is a potent and mutant-selective EGFR inhibitor with excellent in vitro activity in cells with activating EGFR mutations, as well as in cells harbouring the T790M mutation. CNX-2006 is the prototype for CO-1686, which is currently in a Phase I clinical trial for the treatment of EGFR-mutant lung cancer. Synonyms: CNX2006; CNX 2006; N-[3-[[2-[4-[[1-(2-fluoroethyl)azetidin-3-yl]amino]-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide. Grades: 98%. CAS No. 1375465-09-0. Molecular formula: C26H27F4N7O2. Mole weight: 545.543.
Danicamtiv
Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Danicamtiv; MYK-491; MYK 491; MYK491. Product Category: Activators. Appearance: Solid powder. CAS No. 1970972-74-7. Molecular formula: C16H20F3N5O4S. Mole weight: 435.42. Purity: >98%. IUPACName: 4-(1-((3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)sulfonyl)-1-fluoroethyl)-N-(isoxazol-3-yl)piperidine-1-carboxamide. Canonical SMILES: FC(C1CCN(C(NC2=NOC=C2)=O)CC1)(C)S(C3=CN(C)N=C3C(F)F)(=O)=O. Product ID: ACM1970972747. Alfa Chemistry ISO 9001:2015 Certified.
Fleroxacin
Fleroxacin. Group: Biochemicals. Alternative Names: AM-833, ro-23-6240, megalocin, megalone, quinodis, 6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid. Grades: Highly Purified. CAS No. 79660-72-3. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C17H18F3N3O3. US Biological Life Sciences.
Worldwide
Fleroxacin Impurity A
An impurity of Fleroxacin. Fleroxacin is a bactericidal drug that inhibits bacterial DNA gyrase and topoisomerase IV. Synonyms: 6,8-difluoro-1-(2-fluoroethyl)-3-hydroxy-7-(4-methylpiperazin-1-yl)quinolin-4(1H)-one. Grades: > 95%. Molecular formula: C16H18F3N3O2. Mole weight: 341.34.
IDH305 is a potent, selective and brain penetrant inhibitor of mutant isocitrate dehydrogenase 1 (IDH1; IC50s = 27, 28, and 6,140 nM for recombinant IDH1R132H, IDH1R132C, and wild-type IDH1, respectively). It suppresses mutant IDH1-dependent 2-HG production and cell proliferation, and exhibits antitumor activity in preclinical studies. Synonyms: (4R)-4-[(1S)-1-fluoroethyl]-3-[2-({(1S)-1-[4-methyl-2'-(trifluoromethyl)[3,4'-bipyridin]-6-yl]ethyl}amino)pyrimidin-4-yl]-1,3-oxazolidin-2-one. Grades: ≥98%. CAS No. 1628805-46-8. Molecular formula: C23H22F4N6O2. Mole weight: 490.45.
JNJ-42259152
This molecular is a phosphodiesterase 10A PET tracer. Related studies show that PDE10A activity can be reliably quantified and simplified using a reference tissue model with the frontal cortex as reference and a 60-min acquisition period. Uses: Phosphodiesterase 10a pet tracer. Synonyms: JNJ-42259152; JNJ 42259152; JNJ42259152. UNII-B1QHA9M0I6;2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)-3,5-dimethylpyridine. Grades: 98%. CAS No. 1301167-87-2. Molecular formula: C24H23FN4O. Mole weight: 402.46.
Lascufloxacin
Lascufloxacin is an antibacterial drug candidate. Phase-III clinical trials in Respiratory tract infections and in Community-acquired pneumonia in Japan were on-going. Uses: Community-acquired pneumonia; otorhinolaryngological infections; respiratory tract infections. Synonyms: KRP-AM1977; 7-{(3S,4S)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidin- 1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo- 1,4-dihydroquinoline-3-carboxylic acid. Grades: 98%. CAS No. 848416-07-9. Molecular formula: C21H24F3N3O4. Mole weight: 439.43.
TDFA
TDFA is a protein arginine deiminase 4 (PAD4) inhibitor (IC50 = 2.3, 8.5, 26 and 71 μM for PAD4, PAD1, PAD3 and PAD2, respectively) used for the treatment of autoimmune disorders. Synonyms: (3S)-3-[[(2S,3R)-2-acetamido-3-hydroxybutanoyl]amino]-4-[[(2S)-1-amino-5-[(1-amino-2-fluoroethylidene)amino]-1-oxopentan-2-yl]amino]-4-oxobutanoic acid. CAS No. 1345019-64-8. Molecular formula: C17H29FN6O7. Mole weight: 448.45.
YM-53601
YM-53601 is a squalene synthase inhibitor with IC50s of 79 and 90 nM in HepG2 cells and rat liver microsomes, respectively. It is a lipid lowering agent that can reduce plasma cholesterol and triglyceride levels in vivo and inhibit cholesterol biosynthesis in rats (ED50 = 32 mg/kg). It is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and can inhibit the proliferation of HCV. Synonyms: 9H-Carbazole, 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-, hydrochloride (1:1); (E)-3-[2-(Carbazol-2-yloxy)-1-fluoroethylidene]quinuclidine hydrochloride; 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-9H-carbazole, monohydrochloride. Grades: ≥98%. CAS No. 182959-33-7. Molecular formula: C21H21FN2O.HCl. Mole weight: 372.86.
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