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2,3-di-O-acetyl-6-O-tert-butyldimethylsilyl-gamma-cyclodextrin is a modified cyclodextrin used in enhancing the solubility and stability of drugs, improving their bioavailability. It is often employed in developing formulations for poorly soluble drugs. Synonyms: Octakis-(2,3-di-O-acetyl-6-O-tert-butyldimethylsilyl)-γ-cyclodextrin. Molecular formula: C12H224O56SI8. Mole weight: 2313.18.
2,3-di-O-benzyl-6-O-tert-butyldimethylsilyl-gamma-cyclodextrin is a modified cyclodextrin used in the formation of complex structures for the delivery of various drugs. Specifically, it assists in improving the solubility and bioavailability of poorly soluble pharmaceuticals. Synonyms: Octakis-(2,3-di-O-benzyl-6-O-tert-butyldimethylsilyl)-γ-cyclodextrin. Molecular formula: C208H288O40SI8. Mole weight: 4475.79.
2,3-di-O-methyl-6-O-tert-butyldimethylsilyl-gamma-cyclodextrin is primarily utilized as a chiral selective medium in pharmaceutical research. It aids in the separation of drug stereoisomers, thereby optimizing therapeutic effectiveness and minimizing side effects.". Synonyms: Octakis-(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-γ-cyclodextrin. Molecular formula: C112H224O40SI8. Mole weight: 3258.25.
2,6-di-tert-butyldimethylsilyl-gamma-cyclodextrin
2,6-di-tert-butyldimethylsilyl-gamma-cyclodextrin is a versatile biomaterial employed to enhance the solubility and stability of pharmaceutical drugs, especially hydrophobic compounds. This advanced cyclodextrin derivative shows immense potential in the drug development of various diseases by improving drug delivery, prolonging drug release, and increasing drug efficacy. Synonyms: Octakis-(2,6-di-O-tert-butyldimethylsilyl)-γ-cyclodextrin. Molecular formula: C144H304O40Si16. Mole weight: 3125.30.
3,6-di-tert-butylmethylsilyl-gamma-cyclodextrin
3,6-di-tert-butylmethylsilyl-gamma-cyclodextrin is a cutting-edge biomolecule employed in the targeted delivery of drugs, particularly in research on various diseases. With enhanced stability and solubility, it enables efficient encapsulation and controlled release of pharmaceuticals. Synonyms: Octakis-(3,6-di-O-tert-butyldimethylsilyl)-γ-cyclodextrin. Molecular formula: C144H304O40SI16. Mole weight: 4738.47.
6-Mono-tert-butyldimethylsilyl-gamma-cyclodextrin, an immensely versatile compound, finds its application in drug delivery systems and pharmaceutical research. Its profound impact on enhancing the solubility and stability of hydrophobic drugs renders it indispensable in the treatment of an array of diseases, encompassing cancer and microbial infections. Operating as a catalyst for improved drug efficacy, elevated bioavailability, and diminished toxicity, this compound emerges as an invaluable asset in the biomedical industry. Molecular formula: C54H94O40SI. Mole weight: 1542.27.
6-O-tert-butyldimethylsilyl-gamma-cyclodextrin
6-O-tert-butyldimethylsilyl-gamma-cyclodextrin is an exceptionally versatile constituent utilized within the biomedical field owing to its profound potential in mediating compound delivery mechanisms. This specific compound demonstrates remarkable adeptness in encapsulating hydrophobic drug entities, thereby amplifying their solubility and overall stability. Moreover, its intrinsic attributes facilitate a regulated and controlled discharge of therapeutic substances, rendering it exceedingly suitable in research of a broad spectrum of afflictions, encompassing afflictions such as cancer, infections as well as cardiovascular maladies. Synonyms: Octakis-(6-O-tert-butyldimethylsilyl)-γ-cyclodextrin. Molecular formula: C96H192O40Si8. Mole weight: 2211.21.
5-Azido-6-O-(tert-butyldimethylsilyl)-2,3-O-isopropylidene L-gulono-1,4-lactone is a multifaceted compound acting as a precursor in pharmaceutical drug research and development. Furthermore, it serves as a pivotal asset in the pursuit of groundbreaking drug discovery endeavors, targeting meticulously defined diseases or pathways. Synonyms: 5-Azido-5-deoxy-6-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-D-mannonic acid gamma-lactone. CAS No. 118464-49-6. Molecular formula: C15H27N3O5Si. Mole weight: 357.48.
5-O-tert-Butyldimethylsilyl-2,3-O-isopropylidene-D-ribono-1,4-lactone, a paramount intermediary chemical constituent, has been widely exploited in synthesizing ribonucleoside analogues that aim to curb viral maladies, inclusive of hepatitis C and HIV. Furthermore, its application extends to the production of sundry carbohydrates, nucleotides, and nucleosides that exhibit efficacious anti-carcinogenic and antiviral characteristics. Synonyms: 5-O-(tert-Butyldimethylsilyl)-2,3-O-isopropylidene-D-ribono-1,4-lactone; 5-O-(tert-Butyldimethylsilyl)-2,3-O-isopropylidene-D-ribonic acid gamma-lactone; 5-o-t-Butyldimethylsilyl-2,3-o-isopropylidine-D-ribonolactone; 2-O,3-O-Isopropylidene-5-O-(tert-butyldimethylsilyl)-D-ribonic acid gamma-lactone. Grades: ≥96%. CAS No. 75467-36-6. Molecular formula: C14H26O5Si. Mole weight: 302.44.
5-O-(tert-Butyldimethylsilyl)-2,3-O-isopropylidene-L-lyxono-1,4-lactone is a highly complex chemical compound employed in the fabrication of biologically active molecules. Employed extensively in the pharmaceutical domain, the compound serves as an instrumental ingredient for synthesizing medicaments to combat a plethora of maladies, ranging from common viral infections to life-threatening cancerous growths. It stands apart due to its unique molecular form and serves as a chiral foundational block, allowing drug discovery and development to progress forward in a more comprehensive manner. Synonyms: (3aR,6S,6aR)-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dimethyl-6,6a-dihydro-3aH-furo[3,4-d][1,3]dioxol-4-one; 5-O-[(tert-Butyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-L-lyxonic acid gamma-lactone; (3aR,6S,6aR)-6-({[Dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4(3aH)-one. Grades: 95%. CAS No. 1044813-00-4. Molecular formula: C14H26O5Si. Mole weight: 302.44.
Alfa Chemistry's amino acid 2-Cl-Trt resins are available in loadings ranging from 0.4 to 0.7 mmol/g. Since the linked amino acids are N-protected, these resins can be used without pretreatment. Group: Amino acid 2-cl-trt resins. Alternative Names: L-Glutamic acid gamma-t-butyl ester 2-chlorotrityl resin. Pack Sizes: 5g, 25g.
L-685,458
L-685,458 is a potent and selective inhibitor of γ-secretase (IC50 = 17 nM) that shows 50-fold selectivity over a variety of aspartyl proteases. It also inhibits Aβ40 and Aβ42 peptides (in human neuroblastoma cells: IC50 = 48 and 67 nM respectively). Uses: Gamma secretase inhibitors and modulators. Synonyms: L-685458; tert-butyl N-[(2S,3R,5R)-6-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl]carbamate. Grades: >98%. CAS No. 292632-98-5. Molecular formula: C39H52N4O6. Mole weight: 672.85.
Lanolin
Lanolin is a pale yellow-colored, unctuous, waxy substance with a faint, characteristic odor. Melted lanolin is a clear or almost clear, yellow liquid. Synonyms: Adeps lanae; cera lanae; E913; lanolina; lanolin anhydrous; Protalan anhydrous; purified lanolin; refined wool fat. CAS No. 8006-54-0. Product ID: PE-0533. Category: Emulsifying Agents; Ointment Base. Product Keywords: Excipients for Liquid Dosage Form; Emulsifier Excipients; PE-0533; Lanolin; Emulsifying Agents; Ointment Base; ; 8006-54-0. UNII: 7EV65EAW6H. Chemical Name: Anhydrous lanolin. Grade: Pharmceutical Excipients. Administration route: Ophthalmic, otic, topical, and vaginal. Dosage Form: Ophthalmic, otic, topical, and vaginal preparations. Stability and Storage Conditions: Lanolin may gradually undergo autoxidation during storage. To inhibit this process, the inclusion of butylated hydroxytoluene is permitted as an antioxidant. Exposure to excessive or prolonged heating may cause anhydrous lanolin to darken in color and develop a strong rancidlike odor. However, lanolin may be sterilized by dry heat at 150°C. Ophthalmic ointments containing lanolin may be sterilized by filtration or by exposure to gamma irradiation. Lanolin should be stored in a well-filled, well-closed container protected from light, in a cool, dry place. Normal storage life is 2 years. Source and Preparation: Lanolin is a naturally occurring wax-like material obtained from the wool of s
LY 2955303 hydrochloride
LY 2955303 hydrochloride is a potent and selective retinoic acid receptor gamma (RARγ) antagonist (Ki values >1700 nM, >2980 nM, and 1.1 nM for RARα, RARβ, and RARγ, respectively) commonly used for the treatment of osteoarthritis joint pain. Uses: The treatment of osteoarthritis joint pain. Synonyms: LY 2955303 hydrochloride; LY2955303 hydrochloride; LY-2955303 hydrochloride; 4-(5-(3,5-di-tert-butylphenyl)-1-(4-(4-methylpiperazine-1-carbonyl)phenyl)-1H-pyrazol-3-yl)benzoic acid hydrochloride. Grades: 98%. Molecular formula: C36H42N4O3.HCl. Mole weight: 615.2.
PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) (IC50= 0.28 μM) and also an inhibitor of 5-lipoxygenase (IC50= 1.05 μM). Synonyms: (3E)-3-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]oxolan-2-one; alpha-(3,5-di-tert-butyl-4-hydroxybenzylidene)gamma-butyrolactone; KME 4; KME-4. CAS No. 102271-49-8. Molecular formula: C19H26O3. Mole weight: 302.41.
Z-Ile-Leu-aldehyde ia a cell-permeable and reversible inhibitor that inhibits γ-secretase and Notch signaling. It induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity in vitro. It has potent anti-MM activity and reduces osteolytic lesions in vivo. Uses: Gamma secretase inhibitors and modulators. Synonyms: Z-IL-CHO; GSI-XII; Z-Ile-Leu-al; Z Ile Leu al; Z IL CHO; Gamma-secretase inhibitor XII; [(1S,2S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-2-methyl-butyl]-carbamic acid benzyl ester; Benzyl ((2S,3S)-3-methyl-1-(((S)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)carbamate; N-benzyloxycarbonyl-L-isoleucyl-L-leucinal. Grades: ≥95%. CAS No. 161710-10-7. Molecular formula: C20H30N2O4. Mole weight: 362.46.
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