Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| 3-Deoxy-3-fluoro-D-glucitol | 3-Deoxy-3-fluoro-D-glucitol, also known as FDG, is an immensely powerful antidiabetic drug that exhibits significant efficacy in managing type 2 diabetes mellitus. This remarkable medication operates through its ability to impede the glucokinase enzyme, culminating in a notable decline in blood glucose concentrations. Additionally, its intricate mechanism entails the augmentation of insulin sensitivity and facilitation of glucose utilization within the physiological framework. CAS No. 34339-82-7. Molecular formula: C6H13FO5. Mole weight: 184.16. |  |
| ADP-specific glucokinase | Requires Mg2+. The enzyme from Pyrococcus furiosus is highly specific for D-glucose; there is some activity with 2-deoxy-D-glucose, but no activity with D-fructose, D-mannose or D-galactose as the substrate. No activity is detected when ADP is replaced by ATP, GDP, phosphoenolpyruvate, diphosphate or polyphosphate. Group: Enzymes. Synonyms: ADP-dependent glucokinase. Enzyme Commission Number: EC 2.7.1.147. CAS No. 173585-07-4. Hexokinase (ADP-Dependent). Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2977; ADP-specific glucokinase; EC 2.7.1.147; 173585-07-4; ADP-dependent glucokinase. Cat No: EXWM-2977. |  |
| AM-2394 | AM-2394 is a selective Glucokinase agonist (GKA), It activates GK with an EC50 value of 60 nM. AM-2394 increases the affinity of GK for glucose by approximately 10-fold. It shows moderate clearance and good oral bioavailability in animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. Uses: Diabetes. Synonyms: AM-2394; AM 2394; AM2394; 1-(6'-(2-hydroxy-2-methylpropoxy)-4-((5-methylpyridin-3-yl)oxy)-[3,3'-bipyridin]-6-yl)-3-methylurea. Grades: 98%. CAS No. 1442684-77-6. Molecular formula: C22H25N5O4. Mole weight: 423.47. | |
| AM-9514 | AM-9514 is a glucokinase (GK) activator. It shows a favorable combination of in vitro potency, enzyme kinetic properties, acceptable pharmacokinetic profiles in preclinical species, and robust efficacy in a rodent PD model. Glucokinase is very important in regulating glucose homeostasis. AM-9514 may become a drug candidate for the treatment of type 2 diabetes. Uses: Type 2 diabetes. Synonyms: AM-9514; AM9514; AM 9514; 1-(3-((1-ethyl-1H-pyrazol-5-yl)oxy)-5-(((1r,3s)-3-hydroxy-3-methylcyclobutyl)methyl)pyridin-2-yl)-3-methylurea. Grades: 98%. CAS No. 1442677-18-0. Molecular formula: C18H25N5O3. Mole weight: 359.43. | |
| AMG-3969 | AMG-3969 is a potent and selective disruptor of glucokinase-glucokinase regulatory protein interaction (GK-GKRP). AMG-3969 can modulate the blood glucose levels in rodent models of diabetes. Synonyms: 2-[4-[(2S)-4-(6-aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol. Grades: 98% by HPLC. CAS No. 1361224-53-4. Molecular formula: C21H20F6N4O3S. Mole weight: 522.466. | |
| ARRY 403 | ARRY-403 is an orally available Glucokinase stimulants originated by Array BioPharma. ARRY-403 activates human glucokinase in vitro with EC50 of 79 nM at 5 mM glucose and Vmax = 134% compared to the no activator control. It exhibits good in vitro drug-like properties and selectivity against broad panels of receptors and enzymes. But,treatment for Type 2 diabetes mellitus was discontinued. Uses: Type 2 diabetes mellitus. Synonyms: ARRY-403; ARRY-403; ARRY-403; AMG-151; AMG 151; AMG151;(1S)-1-[5-({3-[(2-methylpyridin-3-yl)oxy]-5-(pyridin-2-ylsulfanyl)pyridin-2-yl}amino)-1,2,4-thiadiazol-3-yl]ethane-1,2-diol. Grades: 98%. CAS No. 1304015-76-6. Molecular formula: C20H18N6O3S2. Mole weight: 454.53. | |
| BMS-212 | BMS-212 is a potent and selective stimulator of glucokinase (GK) (EC50 = 35 nM) that is promisingly used as an antidiabetic. BMS-212 has a preference for GK in liver over GK in pancreas, of which the activation may lead to non-glucose-dependent insulin secretion. Half-life of BMS-212 is 4.2h, and oral bioavailability is 15%. Uses: Potential antidiabetic. Synonyms: BMS212; BMS 212. CAS No. 2173153-38-1. Molecular formula: C25H30N3O9PS2. Mole weight: 611.62. | |
| D-Allose-6-phosphate disodium salt hydrate | D-Allose-6-phosphate disodium salt hydrate, a dynamic biomedical substance, is renowned for its efficaciousness in combating specific ailments. Serving as a formidable hindrance to glucokinase, a multifaceted enzyme entangled in numerous metabolic maladies such as type 2 diabetes, this compound boasts an unrivaled chemical configuration that intricately modulates glucose metabolism. Synonyms: 6-O-[Hydroxy(oxo)phosphaniumyl]-D-allose; D-Allose,6-(dihydrogen phosphate); hydroxy-oxo-[(2R,3R,4R,5R)-2,3,4,5-tetrahydroxy-6-oxohexoxy]phosphanium; DTXSID90849400; [(1R,4S)-4-HYDROXY-2-CYCLOPENTEN-1-YL]CARBAMICACID,1,1-DIMETHYLETHYLESTER. CAS No. 82259-50-5. Molecular formula: C6H11O9PNa2. Mole weight: 304.10. | |
| GKA 50 | GKA 50 is a potent glucokinase activator (EC50 = 33 nM). It causes a decrease in plasma glucose levels in diabetic rats and an increase of insulin release from mouse islets of Langerhans. GKA 50 was shown to promote proliferation and prevent apoptosis in rat pancreatic insulinoma-1 beta cell. Synonyms: GKA 50; GKA50; GKA-50; 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino-3-pyridinecarboxylic acid. Grades: ≥98% by HPLC. CAS No. 851884-87-2. Molecular formula: C26H28N2O6. Mole weight: 464.51. | |
| glucokinase | A group of enzymes found in invertebrates and microorganisms that are highly specific for glucose. Group: Enzymes. Synonyms: glucokinase (phosphorylating). Enzyme Commission Number: EC 2.7.1.2. CAS No. 9001-36-9. GCK. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3033; glucokinase; EC 2.7.1.2; 9001-36-9; glucokinase (phosphorylating). Cat No: EXWM-3033. | |
| Glucokinase 2 from Recombinant E.coli | Glucose is phosphorylated to glucose-6-phosphate by glucokinases. This gene is alternatively spliced to generate three different forms of the enzyme; one found in the pancreas and two found in the liver. The main function of this gene is to regulate carbohydrate metabolism. Recombinant human pancreatic Glucokinase has a C-terminal FLAG tag and has 470 amino acid residues. It can be useful for studies including enzyme kinetics, activator screening and kinase selectivity. Group: Enzymes. Synonyms: EC 2.7.1.2; glucokinase; glucokinase (phosphorylating); 9001-36-9; GCK; FGQTL3; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2; Human pancreatic glucokinase; pancreatic glucokinase. Enzyme Commission Number: EC 2.7.1.2. GCK. Mole weight: ca. 32,000. Activity: >350 U/mg protein. Storage: Stable at -20°C for at least one year. Form: Lyophilized. Source: E. coli. EC 2.7.1.2; glucokinase; glucokinase (phosphorylating); 9001-36-9; GCK; FGQTL3; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2; Human pancreatic glucokinase; pancreatic glucokinase. Cat No: NATE-1939. | |
| Glucokinase from Escherichia coli, Recombinant | Glucokinase (EC 2.7.1.2) is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in the liver, pancreas, gut, and brain of humans and most other vertebrates. In each of these organs it plays an important role in the regulation of carbohydrate metabolism by acting as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia. Group: Enzymes. Synonyms: EC 2.7.1.2; glucokinase; glucokinase (phosphorylating); 9001-36-9; GCK; FGQTL3; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2. Enzyme Commission Number: EC 2.7.1.2. CAS No. 9001-36-9. Purity: >95% as judged by SDS-PAGE. GCK. Mole weight: 35 kDa. Activity: 5.8 U/mg protein, 98.6 U/ml. Storage: Glucokinase should be stored at 4 °C, remaining stable up to 3 years under these storage conditions. Form: 3.2 M ammonium sulphate. Source: E. coli. Species: Escherichia coli. EC 2.7.1.2; glucokinase; glucokinase (phosphorylating); 9001-36-9; GCK; FGQTL3; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2. Cat No: NATE-1571. | |
| Glucokinase from Human, recombinant | Glucose is phosphorylated to glucose-6-phosphate by glucokinases. This gene is alternatively spliced to generate three different forms of the enzyme; one found in the pancreas and two found in the liver. The main function of this gene is to regulate carbohydrate metabolism. Recombinant human pancreatic Glucokinase has a C-terminal FLAG tag and has 470 amino acid residues. It can be useful for studies including enzyme kinetics, activator screening and kinase selectivity. Group: Enzymes. Synonyms: EC 2.7.1.2; glucokinase; glucokinase (phosphorylating); 9001-36-9; GCK; FGQTL3; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2; Hexokinase type IV; HK IV; Hexokinase-4; Hexokinase-D. Enzyme Commission Number: EC 2.7.1.2. CAS No. 9001-36-9. Purity: > 80% by SDS-PAGE. GCK. Mole weight: 53.1 kDa. Activity: 303 pmol/min/ug. Storage: Store at -80°C. Avoid repeated freezing and thawing cycles. Form: Liquid. Source: E. coli. Species: Human pancreatic. Glutamine synthetase; GS; EC 6.3.1.2; Glutamate-ammonia ligase; GLNS; PIG43; PIG59; GLUL. Cat No: NATE-1686. | |
| hexokinase | D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Group: Enzymes. Synonyms: hexokinase type IV glucokinase; hexokinase D; hexokinase type IV; hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase. Enzyme Commission Number: EC 2.7.1.1. CAS No. 9001-51-8. Hexokinase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2945; hexokinase; EC 2.7.1.1; 9001-51-8; hexokinase type IV glucokinase; hexokinase D; hexokinase type IV; hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase. Cat No: EXWM-2945. | |
| Hexokinase-1 from Human, Recombinant | A hexokinase is an enzyme that phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate of hexokinases, and glucose-6-phosphate the most important product. Hexokinase can transfer an inorganic phosphate group from ATP to a substrate. Hexokinases should not be confused with glucokinase, which is a specific isoform of hexokinase. While other hexokinases are capable of phosphorylating several hexoses, glucokinase acts with a 50-fold lower substrate affinity and its only hexose substrate is glucose. Hk1 human recombinant produced in e. coli is a single, non-glycosylated, polypeptide chain fused to his tag a...ferase; EC 2.7.1.1; 9001-51-8. Enzyme Commission Number: EC 2.7.1.1. CAS No. 9001-51-8. Purity: Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. Hexokinase. Mole weight: 104.6 kDa. Activity: 7-8 units/ml. Stability: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles. Appearance: Sterile filtered colorless solution. Source: E. coli. Species: Human. Hexokinase-1; EC 2.7.1.1; Hexokinase type I; HK I; Brain form hexokinase; HK1-ta; HK1-tb; HXK1; HK1. Cat No: NATE-0844. | |
| Hexokinase-2 from Human, Recombinant | A hexokinase is an enzyme that phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate of hexokinases, and glucose-6-phosphate the most important product. Hexokinase can transfer an inorganic phosphate group from ATP to a substrate. Hexokinases should not be confused with glucokinase, which is a specific isoform of hexokinase. While other hexokinases are capable of phosphorylating several hexoses, glucokinase acts with a 50-fold lower substrate affinity and its only hexose substrate is glucose. Hk2 human recombinant produced in e. coli is a single, non-glycosylated, polypeptide chain fused to his tag a...rase; EC 2.7.1.1; 9001-51-8. Enzyme Commission Number: EC 2.7.1.1. CAS No. 9001-51-8. Purity: Greater than 90.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. Hexokinase. Mole weight: 104.1 kDa. Activity: 3-4 units/ml. Stability: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles. Appearance: Sterile filtered colorless solution. Source: E. coli. Species: Human. Hexokinase-2; EC 2.7.1.1; HK2; Hexokinase type II; HK II; Muscle form hexokinase; HXK2; DKFZp686M1669. Cat No: NATE-0845. | |
| Hexokinase-3 from Human, Recombinant | A hexokinase is an enzyme that phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate of hexokinases, and glucose-6-phosphate the most important product. Hexokinase can transfer an inorganic phosphate group from ATP to a substrate. Hexokinases should not be confused with glucokinase, which is a specific isoform of hexokinase. While other hexokinases are capable of phosphorylating several hexoses, glucokinase acts with a 50-fold lower substrate affinity and its only hexose substrate is glucose. Hk-3 human recombinant produced in e. coli is a single, non-glycosylated, polypeptide chain fused to his tag ...phosphotransferase; hexokinase; ATP:D-hexose 6-phosphotransferase; EC 2.7.1.1; 9001-51-8. Enzyme Commission Number: EC 2.7.1.1. CAS No. 9001-51-8. Purity: Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. Hexokinase. Mole weight: 101.1 kDa. Stability: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles. Appearance: Sterile filtered colorless solution. Source: E. coli. Species: Human. Hexokinase-3; EC 2.7.1.1; Hexokinase type III; HK III; HXK3; HK3. Cat No: NATE-0846. | |
| Hexokinase-4 from Human, Recombinant | A hexokinase is an enzyme that phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate of hexokinases, and glucose-6-phosphate the most important product. Hexokinase can transfer an inorganic phosphate group from ATP to a substrate. Hexokinases should not be confused with glucokinase, which is a specific isoform of hexokinase. While other hexokinases are capable of phosphorylating several hexoses, glucokinase acts with a 50-fold lower substrate affinity and its only hexose substrate is glucose. Glucokinase human recombinant produced in e. coli is a single, non-glycosylated, polypeptide chain fused to h...se; hexokinase; ATP:D-hexose 6-phosphotransferase; EC 2.7.1.1; 9001-51-8. Enzyme Commission Number: EC 2.7.1.2. CAS No. 9001-36-9. Purity: Greater than 95.0% as determined by SDS-PAGE. Hexokinase. Mole weight: 54.3 kDa. Stability: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles. Appearance: Sterile filtered colorless solution. Source: E. coli. Species: Human. Glucokinase; EC 2.7.1.2; Hexokinase-4; Hexokinase type IV; HK IV; HK4; Hexokinase-D; GCK; GK; GLK; HHF3; HKIV; HXKP; MODY2. Cat No: NATE-0847. | |
| Hexokinase from Kluyveromyces fragilis, Recombinant | A hexokinase is an enzyme that phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate of hexokinases, and glucose-6-phosphate the most important product. Hexokinase can transfer an inorganic phosphate group from ATP to a substrate. Hexokinases should not be confused with glucokinase, which is a specific isoform of hexokinase. While other hexokinases are capable of phosphorylating several hexoses, glucokinase acts with a 50-fold lower substrate affinity and its only hexose substrate is glucose. Group: Enzymes. Synonyms: hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase; hexokinase; ATP:D-hexose 6-phosphotransferase; EC 2.7.1.1. Enzyme Commission Number: EC 2.7.1.1. CAS No. 9001-51-8. Hexokinase. Mole weight: 54 Kd (SDS-PAGE). Activity: > 150 Units / mg. Storage: Below -20°C. Form: Lyophilized powder. Source: E. coli. Species: Kluyveromyces fragilis. hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase; hexokinase; ATP:D-hexose 6-phosphotransferase; EC 2.7.1.1. Cat No: NATE-1034. | |
| Hexokinase from Yeast, chemically modified | A hexokinase is an enzyme that phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate of hexokinases, and glucose-6-phosphate the most important product. Hexokinase can transfer an inorganic phosphate group from ATP to a substrate. Hexokinases should not be confused with glucokinase, which is a specific isoform of hexokinase. While other hexokinases are capable of phosphorylating several hexoses, glucokinase acts with a 50-fold lower substrate affinity and its only hexose substrate is glucose. Recombinant enzyme that converts hexose to hexose-6-phosphate. take advantage of the improved stability in liquid reagents. rely on the proven diagnostic quality of this product. Applications: Use hexokinase in diagnostic tests for blood glucose using the hexokinase method and for the determination of creatine kinase. Group: Enzymes. Synonyms: hexokinase type . Hexokinase. Mole weight: 57 kD (SDS-PAGE). Activity: > 40 U/mg lyophilizate. Stability: At +2 to +8°C within specification range for 18 months. Store dry. Appearance: White lyophilizate. Source: Yeast. hexokinase type IV glucokinase; hexokinase D; hexokinase type IV; hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase; hexokinase; ATP:D-hexose 6-phosphotransferase. Cat No: NATE-0989. | |
| LBX192 | LBX192 is a Liver Targeted Glucokinase Activator. It can activate the GK enzyme in vitro at low nM concentrations and reduce glucose levels during an oral glucose tolerance test in normal as well as diabetic mice. Synonyms: LBX192; LBX 192; LBX-192; NVP-LBX192; NVP-LBX-192; NVP-LBX 192; (R)-3-cyclopentyl-N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)-2-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)propanamide. Grades: 98%. CAS No. 866772-52-3. Molecular formula: C26H33N5O4S2. Mole weight: 543.70. | |
| LY2608204 | LY2608204 activates glucokinase (GK) with EC50 of 42 nM at 10 mM glucose with a concentration dependent manner at lower glucose concentrations. Uses: Enzyme activators. Synonyms: LY-2608204; LY 2608204; LY2608204. Grades: >98%. CAS No. 1234703-40-2. Molecular formula: C28H37N3O3S3. Mole weight: 559.81. | |
| Mannoheptulose | Mannoheptulose is a biochemical compound widely used in the biomedicine industry. Derived from mannose, it possesses potential therapeutic applications in treating diabetes and obesity. Mannoheptulose works by inhibiting the enzyme glucokinase, playing a crucial role in cellular glucose metabolism. Its efficacy and safety profiles make it a promising candidate for further research and development in managing metabolic disorders. CAS No. 654-29-5. Molecular formula: C7H14O7. Mole weight: 210.182. | |
| Native Bacillus sp. Hexokinase | A hexokinase is an enzyme that phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate of hexokinases, and glucose-6-phosphate the most important product. Hexokinase can transfer an inorganic phosphate group from ATP to a substrate. Hexokinases should not be confused with glucokinase, which is a specific isoform of hexokinase. While other hexokinases are capable of phosphorylating several hexoses, glucokinase acts with a 50-fold lower substrate affinity and its only hexose substrate is glucose. Applications: This enzyme is useful for enzymatic determination of glucose or creatinine kinase activity when coupled with glucose-6-phosphate dehydrogenase. Group: Enzymes. Synonyms: hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase; hexokinase; ATP:D-hexose 6-phosphotransferase. Enzyme Commission Number: EC 2.7.1.1. CAS No. 9001-51-8. Hexokinase. Mole weight: 68 kDa (gel filtration). Activity: More than 250 U/mg solid. Appearance: White amorphous powder, lyophilized. Storage: Storage at -20°C in the presence of a desiccant is recommended. Form: Freeze dried powder. Source: Bacillus sp. hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase; hexokinase; ATP:D-hexose 6-phosphotransferase; EC 2.7.1.1. Cat No: NATE-1157. | |
| Native Bacillus stearothermophilus Glucokinase | Glucokinase (EC 2.7.1.2) is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in the liver, pancreas, gut, and brain of humans and most other vertebrates. In each of these organs it plays an important role in the regulation of carbohydrate metabolism by acting as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia. Group: Enzymes. Synonyms: EC 2.7.1.2; glucokinase; glucokinase (phosphorylating); 9001-36-9; GCK; FGQTL3; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2. Enzyme Commission Number: EC 2.7.1.2. CAS No. 9001-36-9. GCK. Activity: > 300 units/mg protein. Storage: -20°C. Form: Lyophilized powder containing Tris buffer salts. Source: Bacillus stearothermophilus. EC 2.7.1.2; glucokinase; glucokinase (phosphorylating); 9001-36-9; GCK; FGQTL3; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2. Cat No: NATE-0282. | |
| Native Hexokinase (ADP-Dependent) from Pyrococcus furiosus | In enzymology, a ADP-Dependent Hexokinase (EC 2.7.1.147) is an enzyme that catalyzes the chemical reaction: D-Glucose + ADP ? D-Glucose-6-phosphate + AMP. Applications: Useful for the enzymatic determination of adp. Group: Enzymes. Synonyms: ADP-dependent glucokinase; ADP-specific glucokinase; ADP:D-glucose 6-phosphotransferase; EC 2.7.1.147. Enzyme Commission Number: EC 2.7.1.147. CAS No. 173585-07-4. Hexokinase (ADP-Dependent). Mole weight: 100 kDa (gel filtration) 51 kDa (SDS-PAGE). Activity: More than 30 U/mg solid. Appearance: White amorphous powder, lyophilized. Storage: Storage at ?20°C in the presence of a desiccant is recommended. Source: Pyrococcus furiosus. ADP-dependent glucokinase; ADP-specific glucokinase; ADP:D-glucose 6-phosphotransferase; EC 2.7.1.147. Cat No: NATE-1135. | |
| Native Hexokinase (ADP-Dependent) from Thermococcus litoralis | In enzymology, a ADP-Dependent Hexokinase (EC 2.7.1.147) is an enzyme that catalyzes the chemical reaction: D-Glucose + ADP ? D-Glucose-6-phosphate + AMP. Applications: Useful for the enzymatic determination of 1,5 anhydroglucitol. Group: Enzymes. Synonyms: ADP-dependent glucokinase; ADP-specific glucokinase; ADP:D-glucose 6-phosphotransferase; EC 2.7.1.147. Enzyme Commission Number: EC 2.7.1.147. CAS No. 173585-07-4. Hexokinase (ADP-Dependent). Mole weight: 50 kDa (gel filtration) 50 kDa (SDS-PAGE). Activity: More than 25 U/mg solid. Appearance: White amorphous powder, lyophilized. Storage: Storage at ?20°C in the presence of a desiccant is recommended. Source: Thermococcus litoralis. ADP-dependent glucokinase; ADP-specific glucokinase; ADP:D-glucose 6-phosphotransferase; EC 2.7.1.147. Cat No: NATE-1136. | |
| Native Microorganism Hexokinase | A hexokinase is an enzyme that phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate of hexokinases, and glucose-6-phosphate the most important product. Hexokinase can transfer an inorganic phosphate group from ATP to a substrate. Hexokinases should not be confused with glucokinase, which is a specific isoform of hexokinase. While other hexokinases are capable of phosphorylating several hexoses, glucokinase acts with a 50-fold lower substrate affinity and its only hexose substrate is glucose. Applications: The enzyme is useful for enzymatic determination of glucose, adenosine-5'-triphosphate (atp) and creatine phosphokinase when coupled with glucose-6-phosphate dehydrogenase. Group: Enzymes. Synonyms: Hexokinase; EC 2.7.1.1; hexokinase type IV glucokinase; hexokinase D; hexokinase type IV; hexokinase (phosphorylating); ATP-dependen. Enzyme Commission Number: EC 2.7.1.1. Mole weight: approx. 82 kDa (by gel filtration). Activity: 150U/mg-solid or more. Appearance: White amorphous powder, lyophilized. Form: Freeze dried powder. Source: Microorganism. Hexokinase; EC 2.7.1.1; hexokinase type IV glucokinase; hexokinase D; hexokinase type IV; hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase; ATP: D-hexose 6-phosphotransferase. Cat No: DIA-202. | |
| Native Rhodothermus obamensis Hexokinase | A hexokinase is an enzyme that phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate of hexokinases, and glucose-6-phosphate the most important product. Hexokinase can transfer an inorganic phosphate group from ATP to a substrate. Hexokinases should not be confused with glucokinase, which is a specific isoform of hexokinase. While other hexokinases are capable of phosphorylating several hexoses, glucokinase acts with a 50-fold lower substrate affinity and its only hexose substrate is glucose. Applications: This enzyme is useful for enzymatic determination of glucose or creatinine kinase activity when coupled with glucose-6-phosphate dehydrogenase. Group: Enzymes. Synonyms: hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase; hexokinase; ATP:D-hexose 6-. Enzyme Commission Number: EC 2.7.1.1. CAS No. 9001-51-8. Hexokinase. Mole weight: 140 kDa (gel filtration). Activity: 100 - 400 U/mg. Appearance: White to light grayish lyophilized powder. Storage: Storage at -20°C in the presence of a desiccant is recommended. Form: Freeze dried powder. Source: Rhodothermus obamensis. hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase; hexokinase; ATP:D-hexose 6-phosphotransferase; EC 2.7.1.1. Cat No: NATE-1156. | |
| Native Saccharomyces cerevisiae Hexokinase | A hexokinase is an enzyme that phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate of hexokinases, and glucose-6-phosphate the most important product. Hexokinase can transfer an inorganic phosphate group from ATP to a substrate. Hexokinases should not be confused with glucokinase, which is a specific isoform of hexokinase. While other hexokinases are capable of phosphorylating several hexoses, glucokinase acts with a 50-fold lower substrate affinity and its only hexose substrate is glucose. Group: Enzymes. Synonyms: hexokinase type IV glucokinase; hexokinase D; hexokinase type IV. Enzyme Commission Number: EC 2.7.1.1. CAS No. 9001-51-8. Hexokinase. Mole weight: ~ 54 kDa (monomer); ~110 kDa (dimer). Activity: Type I, > 350 units/mg protein; Type II, > 25 units/mg protein (biuret); Type III, > 130 units/mg protein (biuret). Storage: -20°C. Form: Type I, Lyophilized powder containing phosphate/Citrate pH approx. 7.0; Type II, Type III, Lyophilized powder containing approx. 15% sodium Citrate. Source: Saccharomyces cerevisiae. hexokinase type IV glucokinase; hexokinase D; hexokinase type IV; hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase; hexokinase; ATP:D-hexose 6-phosphotransferase; EC 2.7.1.1; 9001-51-8. Cat No: NATE-0342. | |
| Native Zymomonas mobilis Glucokinase | Glucokinase (EC 2.7.1.2) is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in the liver, pancreas, gut, and brain of humans and most other vertebrates. In each of these organs it plays an important role in the regulation of carbohydrate metabolism by acting as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia. Applications: The enzyme is useful for diagnostic reagent, for example, glucose determination or ck determination, and for the specificdetermination of glucose. tris-hci buffer is not suitable for the practical use of zm-gck. Group: Enzymes. Synonyms: EC 2.7.1.2; glucokinase; glucokinase (phosphorylating); 9001-36-9; GCK; FGQTL3; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2. Enzyme Commission Number: EC 2.7.1.2. CAS No. 9001-36-9. GCK. Mole weight: ca. 66,000; Subunit molecular weight : ca. 33,000. Appearance: Lyophilized. Storage: Stable at -20 °C for at least one year. Source: Zymomonas mobilis. EC 2.7.1.2; glucokinase; glucokinase (phosphorylating); 9001-36-9; GCK; FGQTL3; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2. Cat No: NATE-1903. | |
| Nerigliatin | Nerigliatin (PF-04937319) is a orally active glucokinase activator ( GKA ) with EC 50 value of 154.4 μM. Nerigliatin maintains glucose-lowering efficacy. Nerigliatin causes peripheral nerve degeneration. Nerigliatin can be used in type 2 diabetes research. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-04937319. CAS No. 1245603-92-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108328. |  |
| N-Glycinyl-1-deoxy-D-glucitol | N-Glycinyl-1-deoxy-D-glucitol is also known as N-GDN, specifically designed for studying diabetes. Its exceptional glucokinase activation properties not only magnify insulin secretion but also augment glucose utilization. Synonyms: N-Glucosylglycine. Molecular formula: C8H17NO7. Mole weight: 239.22. | |
| PF-04937319 | This active molecular is a glucokinase activator originated by Pfizer and EC50 value is 174 nM. PF-04937319 can improve glycemic control in adults with type 2 diabetes when applicated in conjunction with metformin and it can also maintain lower-glucose levels without it resulting in hypoglycemia. However,clinical trials were discontinued for Type 2 diabetes mellitus in 2016. Uses: Type 2 diabetes mellitus. Synonyms: PF-04937319; PF04937319; PF 04937319; PF-4937319; PF 4937319; PF4937319; N,N-dimethyl-5-((2-methyl-6-((5-methylpyrazin-2-yl)carbamoyl)benzofuran-4-yl)oxy)pyrimidine-2-carboxamide. Grades: 98%. CAS No. 1245603-92-2. Molecular formula: C22H20N6O4. Mole weight: 432.44. | |
| PF-04991532 | This active molecular is a hepatoselective glucokinase activator that reduces MDG (mean daily glucose), FPG (fasting plasma glucose) and glucose excursion in humans. PF-04991532 may offer glycemic control without inducing hepatic steatosis. PF-04991532 was developed by Pfizer but was discontinued in Phase-II for Type-2 diabetes mellitus in USA in 2012. Uses: Type 2 diabetes mellitus. Synonyms: PF-04991532; PF 04991532; PF04991532; PF-4991532; PF4991532; PF 4991532; UNII-AJ212MS2O2; CHEMBL2165620; AJ212MS2O2; SCHEMBL1711504; BDBM50394681; 6-[[(2S)-3-cyclopentyl-2-[4-(trifluoromethyl)imidazol-1-yl]propanoyl]amino]pyridine-3-carboxylic acid. Grades: 98%. CAS No. 1215197-37-7. Molecular formula: C18H19F3N4O3. Mole weight: 396.37. | |
| polyphosphate-glucose phosphotransferase | Requires a neutral salt, e.g. KCl, for maximum activity. Also acts on glucosamine. Group: Enzymes. Synonyms: polyphosphate glucokinase; polyphosphate-D-(+)-glucose-6-phosphotransferase; polyphosphate-glucose 6-phosphotransferase. Enzyme Commission Number: EC 2.7.1.63. CAS No. 9033-50-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3094; polyphosphate-glucose phosphotransferase; EC 2.7.1.63; 9033-50-5; polyphosphate glucokinase; polyphosphate-D-(+)-glucose-6-phosphotransferase; polyphosphate-glucose 6-phosphotransferase. Cat No: EXWM-3094. | |
| Ro 28-1675 | A cell-permeable thiazolyl-propanamide compound that acts as a glucokinase (GK) activator by increasing Vmax and decreasing [S]1/2 of GK-catalyzed reaction as well as freeing GK from the inhibitory action of GK regulatory protein (GKRP), resulting in increased. Induces GK nuclear-to-cytosol translocation in primary rat hepatocytes and reduces glucose concentration for insulin secretion stimulation from isolated rat pancreatic islets (threshold [glucose] = 3 mM vs 6 mM with or without 3 μM Ro-28-1675). Exhibits in vivo glucose-lowering and insulin-releasing activity in non-diabetic C57BL/6 mice and Wistar rats and is efficacious in several murine and rodent type II diabetes mellitus (T2DM) models (10 to 50 mg/kg via p.o.). Does not affect hexokinase I or II activity. Synonyms: RO28-1675; RO-28-1675; RO 28-1675; RO028-1675; RO-028-1675; RO 028-1675; RO281675; RO 281675; RO-281675; Ro 0281675; Ro-0281675; Ro0281675. Grades: >98%. CAS No. 300353-13-3. Molecular formula: C18H22N2O3S2. Mole weight: 378.51. | |
| RO4389620 | RO4389620 is a glucokinase activator. It greatly enhances glucose-induced pancreatic islet respiration and insulin release. It has an acute glucose-lowering action in patients with mild type 2 diabetes by a generalized enhancement of β-cell function and fasting restricted changes in glucose turnover. It was developed by Roche and was in clinic phase 2 trials, but now it is terminated. Uses: Ro4389620 has an acute glucose-lowering action in patients with mild type 2 diabetes. Synonyms: RO-4389620; RO 4389620; Piragliatin; (R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-((R)-3-oxocyclopentyl)-N-(pyrazin-2-yl)propanamide. Grades: 98%. CAS No. 625114-41-2. Molecular formula: C19H20ClN3O4S. Mole weight: 421.89. | |
| 4-Toluoyl 2,3-di-O-benzoyl-4,6-O-benzylidene-b-D-thioglucopyranoside | 4-Toluoyl 2,3-di-O-benzoyl-4,6-O-benzylidene-b-D-thioglucopyranoside, an indispensable compound with extensive applications in the field of biomedicine, holds immense scientific value. Its remarkable functionality as a glucokinase enzyme activator offers promising prospects for the treatment of diabetes. Moreover, the inhibitory effects demonstrated against pancreatic α-amylase and α-glucosidase make it a compelling contender for the advancement of anti-diabetic pharmaceuticals. Molecular formula: C35H30O8S. Mole weight: 610.68. | |
Our database is helping our users find suppliers everyday.
