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| Product | Description | |
|---|---|---|
| glucose-6-phosphatase | Wide distribution in animal tissues. Also catalyses potent transphosphorylations from carbamoyl phosphate, hexose phosphates, diphosphate, phosphoenolpyruvate and nucleoside di- and triphosphates, to D-glucose, D-mannose, 3-methyl-D-glucose or 2-deoxy-D-glucose [cf. EC 2.7.1.62 (phosphoramidate-hexose phosphotransferase), EC 2.7.1.79 (diphosphate-glycerol phosphotransferase) and EC 3.9.1.1 (phosphoamidase)]. Group: Enzymes. Synonyms: glucose 6-phosphate phosphatase. Enzyme Commission Number: EC 3.1.3.9. CAS No. 9001-39-2. G6Pase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3696; glucose-6-phosphatase; EC 3.1.3.9; 9001-39-2; glucose 6-phosphate phosphatase. Cat No: EXWM-3696. |  |
| Native Rabbit Glucose-6-Phosphatase | Glucose 6-phosphatase (EC 3.1.3.9, G6Pase) is an enzyme that hydrolyzes glucose-6-phosphate, resulting in the creation of a phosphate group and free glucose. Glucose is then exported from the cell via glucose transporter membrane proteins. This catalysis completes the final step in gluconeogenesis and glycogenolysis and therefore plays a key role in the homeostatic regulation of blood glucose levels. Applications: Glucose-6-phosphatase was used to study the effects of clausena anisata (wild hook leaf) extracts on selected diabetes-related metabolizing enzymes. Group: Enzymes. Synonyms: EC 3.1.3.9; glucose 6-phosphate phosphatase; G6Pase; 9001-39-2; glucose-6-phosphatase. Enzyme Commission Number: EC 3.1.3.9. CAS No. 9001-39-2. Purity: Protein ~30 % (balance mostly sucrose). G6Pase. Activity: > 0.05 units/mg protein. Storage: -20°C. Form: powder with sucrose. Source: Rabbit liver. Species: Rabbit. EC 3.1.3.9; glucose 6-phosphate phosphatase; G6Pase; 9001-39-2; glucose-6-phosphatase. Cat No: NATE-0269. | |
| 1,2,-O-Isopropylene-3,4-O-di-O-benzyl- β-D-fructofuranose-2-dibenzyl Phosphate | 1,2,-O-Isopropylene-3,4-O-di-O-benzyl- β-D-fructofuranose-2-dibenzyl Phosphate is an intermediate in the synthesis of D-Fructose 2,6-bisphosphate Disodium Salt (F792530) which is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg, 100mg. Molecular Formula: C37H41O9P. US Biological Life Sciences. |  Worldwide |
| 1,2,-O-Isopropylene-3,4-O-di-O-benzyl-β-D-fructofuranose-2-dibenzyl Phosphate | 1,2,-O-Isopropylene-3,4-O-di-O-benzyl-β-D-fructofuranose-2-dibenzyl Phosphate is an intermediate in the synthesis of D-Fructose 2,6-bisphosphate Disodium Salt which is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes. Molecular formula: C37H41O9P. Mole weight: 660.69. |  |
| a-D-Glucose-1-phosphate disodium salt hydrate | a-D-Glucose-1-phosphate disodium salt hydrate is a key compound used in biomedicine for the research of glycogen storage diseases, specifically those resulting from defects in the glucose-6-phosphatase enzyme. By providing exogenous glucose-1-phosphate, it aids in bypassing the enzyme deficiency and replenishing glucose levels, addressing the associated symptoms and complications of these diseases. Synonyms: a-D-Glucopyranose 1-phosphate Cori ester. CAS No. 56401-20-8. Molecular formula: C6H11O9P.2Na.xH2O. Mole weight: 304.10 (anydrous basis). | |
| D-Glucose 2-phosphate | D-Glucose 2-phosphate is a fundamental compound used in the research of glycogen storage diseases, particularly glucose-6-phosphatase deficiency. As a vital substrate within the carbohydrate metabolism pathway, it serves as an alternate energy source, manifesting its profound impact on energy production. Synonyms: 2-(Dihydrogen phosphate)D-glucose; D-gluco-3,4,5,6-Tetrahydroxy-2-phosphonooxy-hexanal; glucose phosphate; O2-Phosphono-D-glucose; [(2R,3S,4R,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl] dihydrogen phosphate. CAS No. 67101-62-6. Molecular formula: C6H13O9P. Mole weight: 260.10. | |
| diphosphate-glycerol phosphotransferase | May be identical with EC 3.1.3.9 glucose-6-phosphatase. Group: Enzymes. Synonyms: PPi-glycerol phosphotransferase; pyrophosphate-glycerol phosphotransferase. Enzyme Commission Number: EC 2.7.1.79. CAS No. 37278-13-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3108; diphosphate-glycerol phosphotransferase; EC 2.7.1.79; 37278-13-0; PPi-glycerol phosphotransferase; pyrophosphate-glycerol phosphotransferase. Cat No: EXWM-3108. | |
| inorganic diphosphatase | Specificity varies with the source and with the activating metal ion. The enzyme from some sources may be identical with EC 3.1.3.1 (alkaline phosphatase) or EC 3.1.3.9 (glucose-6-phosphatase). A form of this enzyme with a molecular mass of about 90 kDa is found in tonoplasts of plants and fungi, where it imports protons from the cytosol into the vacuolar lumen. Group: Enzymes. Enzyme Commission Number: EC 3.6.1.1. CAS No. 9024-82-2. Inorganic pyrophosphatase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4593; inorganic diphosphatase; EC 3.6.1.1; 9024-82-2. Cat No: EXWM-4593. | |
| phosphoamidase | Also acts on N-phospho-arginine and other phosphoamides. Possibly identical with EC 3.1.3.9 (glucose-6-phosphatase) or EC 3.1.3.16 (protein-serine/threonine phosphatase). Group: Enzymes. Synonyms: creatine phosphatase. Enzyme Commission Number: EC 3.9.1.1. CAS No. 9001-79-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4749; phosphoamidase; EC 3.9.1.1; 9001-79-0; creatine phosphatase. Cat No: EXWM-4749. | |
| phosphoramidate-hexose phosphotransferase | Activity is observed with several hexoses; of these glucose is the best substrate and the product from it is α-D-glucose 1-phosphate. The phosphoramidate donor can be replaced by N-phosphoglycine and by an N-phosphohistidine. May be identical with EC 3.1.3.9 glucose-6-phosphatase. Group: Enzymes. Synonyms: phosphoramidate-hexose transphosphorylase; phosphoramidic-hexose transphosphorylase; phosphoramidate:hexose 1-phosphotransferase. Enzyme Commission Number: EC 2.7.1.62. CAS No. 9031-45-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3093; phosphoramidate-hexose phosphotransferase; EC 2.7.1.62; 9031-45-2; phosphoramidate-hexose transphosphorylase; phosphoramidic-hexose transphosphorylase; phosphoramidate:hexose 1-phosphotransferase. Cat No: EXWM-3093. | |
| Pluraflavin A | Pluraflavin A is an antitumor antibiotic produced by Saccharothrix sp. DSM 12931. Pluraflavin A has the effect of inhibiting the transcription of glucose-6-phosphatase gene and has good anti-proliferation activity on tumor cells. Molecular formula: C43H54N2O14. Mole weight: 822.89. | |
| ROR-alpha/gamma Agonist | A cell-permeable diaryl amide derived from T1317 (a known LXR agonist and retinoic acid receptor (ROR) inverse agonist) that acts as a highly selective agonist of RORalpha/gamma and does not exhibit affinity for FXR, LXRa and LXRb. Shown to stabilize p53 in cancer cells and increase the expression of p21 and PUMA. Induces apoptosis in hepatocellular carcinoma (HepG2) cells in a RORa and p53-dependent process. Also reported to increase the expression of Sox4 and REV-ERBa in HepG2 cells. Exhibits suitable pharmacokinetic properties with sustained plasma levels even after 8 hours following a single i.p. injection. Exposure to SR1078 Induces expression of glucose-6-phosphatase and fibroblast growth factor 21 in murine models (10mg/kg/i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SHIP2 Inhibitor II, CPDA | A cell-permeable aminopyridine acetamide based compound that acts as an inhibitor of SH2 domain-containing inositol 5-phosphatase 2 (SHIP2) that can overcome insulin resistance in 3T3-L1 adipocytes. Enhances insulin-stimulated Akt phosphorylation (Thr308) in TNFa-treated 3T3-L1 adipocytes (~10uM) and in primary cultured neurons from rat cerebral cortex. Improves glucose tolerance in db/db mice (~300mg/kg b.i.d) without affecting their fasting glucose levels. Also reduces the expression levels of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??ClF?N?O?, Primary Target: SHIP2. US Biological Life Sciences. | Worldwide |
| Thielavin A | The fungal metabolite thielavin A and its relatives are glucose-6-phosphatase inhibitors. The three benzoic acid units are essential for inhibition. Thielavin A was originally isolated as a inhibitor of prostaglandin biosynthesis. The closely related thielavin B is a telomerase and cell wall transglycosylation inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 71950-66-8. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Thielavin A | Thielavin A is a glucose-6-phosphatase (G6Pase) inhibitor produced by Chaetomium carinthiacum. Grades: >95% by HPLC. CAS No. 71950-66-8. Molecular formula: C29H30O10. Mole weight: 538.54. | |
| Thielavin D | Thielavin D is a glucose-6-phosphatase (G6Pase) inhibitor produced by Chaetomium carinthiacum. Molecular formula: C30H32O10. Mole weight: 552.57. | |
| Thielavin P | Thielavin P is a glucose-6-phosphatase (G6Pase) inhibitor produced by Chaetomium carinthiacum. Molecular formula: C30H32O10. Mole weight: 552.57. | |
| AS 1842856 | AS 1842856 is a potent and selective inhibitor of Forkhead box protein O1 transcription factor (FoxO1; IC50 = 33 nM). AS 1842856 reduces glucose production in dose manner via the inhibition of glucose-6 phosphatase and phosphoenolpyruvate carboxykinase mRNA levels in a rat hepatic cell line. AS 1842856 is promisingly to be a therapy of type 2 diabetes mellitus and obesity. Uses: Potential treatment of type 2 diabetes mellitus and obesity. Synonyms: AS1842856; AS-1842856; AS 1842856. 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid. Grades: 99%. CAS No. 836620-48-5. Molecular formula: C18H22FN3O3. Mole weight: 347.38. | |
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