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| Product | Description | |
|---|---|---|
| Glycochenodeoxycholic acid | Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Chenodeoxycholylglycine. CAS No. 640-79-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-N2334. |  |
| Glycochenodeoxycholic acid-d4 | Glycochenodeoxycholic acid-d 4 is the deuterium labeled Glycochenodeoxycholic acid. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) induces hepatocyte apoptosis[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Chenodeoxycholylglycine-d4. CAS No. 1201918-16-2. Pack Sizes: 1 mg. Product ID: HY-N2334S. | |
| Glycochenodeoxycholic Acid-d5 3-Sulfate Disodium Salt | Labeled Glycochenodeoxycholic Acid 3-Sulfate. A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic. Group: Biochemicals. Alternative Names: N-[(3α,5 β,7α)-7-Hydroxy-24-oxo-3-(sulfooxy)cholan-24-yl]glycine-d5 Disodium Salt; Glycochenodeoxycholic Acid 3α-Sulfate-d5 Disodium Salt. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. US Biological Life Sciences. |  Worldwide |
| Glycochenodeoxycholic acid sodium salt | Glycochenodeoxycholic acid sodium salt (Sodium glycochenodeoxycholate) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid sodium salt inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid sodium salt induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid sodium salt is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Chenodeoxycholylglycine sodium salt; Sodium glycochenodeoxycholate. CAS No. 16564-43-5. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-N2334A. | |
| 7-Formyloxy Glycochenodeoxycholic Acid-d5 Ethyl Ester | Glycochenodeoxycholic Acid-d5 derivative. Group: Biochemicals. Alternative Names: N-[(3α,5 β,7α)-7-(Formyloxy)-3-hydroxy-24-oxocholan-24-yl]-glycine Ethyl Ester. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline | 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline is used in the synthesis of Glycochenodeoxycholic Acid 3-Sulfate Disodium Salt which is a bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic. Synonyms: 1-(Ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline; 2-Ethoxy-1(2H)-quinolinecarboxylic acid ethyl ester; 2-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline; 2-Ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline; EEDQ; Ethyl 2-ethoxy-1(2H)-quinolinecarboxylate; N-(Ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline; N-Carbethoxy-2-ethoxy-1,2-dihydroquinoline; NSC 147831; Ethyl N-(2-ethoxy-1,2-dihydroquinoline)carboxylate. Grades: 99 % (HPLC). CAS No. 16357-59-8. Molecular formula: C14H17NO3. Mole weight: 247.29. |  |
| Chenodeoxycholic Acid-d7 (Major) | Chenodeoxycholic Acid-d7 is a labelled analogue of Chenodeoxycholic Acid (C291900), which is a major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion. Fcilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol. In addition, Chenodeoxycholic Acid-d7 is an intermediate in synthesizing Glycochenodeoxycholic Acid-d7 Sodium Salt (G641257), which is a labelled Glycochenodeoxycholic Acid (G641255). A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C24H33D7O4. US Biological Life Sciences. | Worldwide |
| Sodium glycochenodeoxycholate | Sodium glycochenodeoxycholate is a bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic. Synonyms: Glycochenodeoxycholic acid sodium salt. CAS No. 16564-43-5. Molecular formula: C26H42NNaO5. Mole weight: 471.614. | |
| Sodium glycochenodeoxycholate | Sodium glycochenodeoxycholate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Glycochenodeoxycholic acid sodium salt. CAS No. 16564-43-5. Molecular formula: C26H42NNaO5. Mole weight: 471.6. Purity: 97%+. IUPACName: Sodium;2-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetate. Canonical SMILES: CC(CCC(=O)NCC(=O)[O-])C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C.[Na+]. Product ID: ACM16564435. Alfa Chemistry ISO 9001:2015 Certified. |  |
| bile-salt sulfotransferase | The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species. This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase. In addition to the 5β-bile acid glycolithocholate, deoxycholate, 3β-hydroxy-5-cholenoate and dehydroepiandrosterone (3β-hydroxyandrost-5-en-17-one) also act as substrates [see also EC 2.8.2.2 (alcohol sulfotransferase) and EC 2.8.2.34 (glycochenodeoxycholate sulfotransferase)]. May be identical to EC 2.8.2.2. Group: Enzymes. Synonyms: BAST I; bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase; bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase; bile acid sulfotransferase I; glycolithocholate sulfotransferase. Enzyme Commission Number: EC 2.8.2.14. CAS No. 65802-92-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3372; bile-salt sulfotransferase; EC 2.8.2.14; 65802-92-8; BAST I; bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase; bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase; bile acid sulfotransferase I; glycolithocholate sulfotransferase. Cat No: EXWM-3372. |  |
| glycochenodeoxycholate sulfotransferase | The enzyme specifically sulfates glycochenodeoxycholate at the 7α-position (see also EC 2.8.2.14 bile-salt sulfotransferase). The monohydroxy bile acids glycolithocholate, chenodeoxycholate and ursodeoxycholate act as inhibitors. Group: Enzymes. Synonyms: bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase; bile acid:PAPS:sulfotransferase; BAST. Enzyme Commission Number: EC 2.8.2.34. CAS No. 72668-90-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3394; glycochenodeoxycholate sulfotransferase; EC 2.8.2.34; 72668-90-7; bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase; bile acid:PAPS:sulfotransferase; BAST. Cat No: EXWM-3394. | |
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