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| Product | Description | |
|---|---|---|
| 2`,3`-Dideoxy-5`-guanylic Acid | 2`,3`-Dideoxy-5`-guanylic Acid is a component used in pyrophosphorolysis activated polymerization applied to allele-specific amplification and nucleic acid sequence detection. Group: Biochemicals. Grades: Highly Purified. CAS No. 85956-71-4. Pack Sizes: 25mg, 100mg. Molecular Formula: C10H14N5O6P, Molecular Weight: 331.22. US Biological Life Sciences. |  Worldwide |
| 2'-Deoxy-5'-guanylic Acid Disodium Salt Hydrate | 2'-Deoxy-5'-guanylic Acid Disodium Salt Hydrate is a substrate of guanylate kinase. Group: Biochemicals. Grades: Highly Purified. CAS No. 146877-98-7. Pack Sizes: 500mg, 1g. Molecular Formula: C10H14N5Na2O7P. (H2O)x, Molecular Weight: 393.201801999999. US Biological Life Sciences. | Worldwide |
| 3'-O-Methyl-5'-guanylic acid | 3-O-Methyl-5-guanylic acid is a pivotal molecule extensively employed in the realm of compound is assuming an eminent position in the research and development of sundry pharmaceutical agents and investigations concerning RNA and DNA architectures. Synonyms: 3'-Ome-GMP; [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-4-hydroxy-3-methoxyoxolan-2-yl]methyl dihydrogen phosphate. CAS No. 400806-41-9. Molecular formula: C11H16N5O8P. Mole weight: 377.25. |  |
| 5'-Guanylic acid | 5'-Guanylic acid. Group: Biochemicals. CAS No. 85-32-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 5'-Guanylic acid,8-bromo-,monosodium salt(9ci) | Heterocyclic Organic Compound. Alternative Names: B2131_SIGMA, 8-Bromoguanosine 5-monophosphate sodium salt, 8-Bromoguanosine 5 inverted exclamation marka-monophosphate sodium salt, 102213-02-5. CAS No. 102213-02-5. Molecular formula: C10H13BrN5O8P.Na. Mole weight: 464.1. Purity: 0.96. IUPACName: [5-(2-amino-8-bromo-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate;sodium. Canonical SMILES: C (C1C (C (C (O1)N2C3=C (C (=O)N=C (N3)N)N=C2Br)O)O)OP (=O) (O)[O-]. [Na+]. Catalog: ACM102213025. |  |
| 2'-Deoxy-2'-fluoroguanosine-5'-monophosphate | 2'-Deoxy-2'-fluoroguanosine-5'-monophosphate is a vital compound used in the biomedical industry. It exhibits therapeutic potential in the treatment of certain viral infections and cancer. This product could be employed as an antiviral agent, targeting viral replication pathways, or as an anticancer agent for inhibiting tumor growth. Synonyms: 2'-Deoxy-2'-fluoro-5'-guanylic acid. CAS No. 170784-58-4. Molecular formula: C10H13FN5O7P. Mole weight: 365.21. | |
| 2'-Deoxy-6-thioguanosine-5'-monophosphate | 2'-Deoxy-6-thioguanosine-5'-monophosphate is an innovative pharmaceutical entity, exquisitely designed for unveiling remarkable antiviral potency, assiduously directing its action towards impeding the pernicious propagation of RNA viruses. Deploying its inhibitory prowess upon viral enzyme activity, it efficaciously curtails the abhorrent virus's proclivity to proliferate, ensuing in a substantial amelioration of both the intensity and duration of the affliction. Synonyms: 2'-Deoxy-6-thio-5'-guanylic acid. CAS No. 15303-00-1. Molecular formula: C10H14N5O6PS. Mole weight: 363.29. | |
| 2'-Deoxyguanosine 3'-monophosphate sodium salt | 2'-Deoxyguanosine 3'-monophosphate sodium salt. Alternative Names: 2-Deoxyguanosine-3-Monophosphate; 2-DEOXYGUANOSINE 3-MONOPHOSPHATE SODIUM; 2-Deoxy-3-guanylic acid disodium salt. CAS No. 102814-03-9. Molecular formula: C10H12N5O7P·2Na. Mole weight: 391.19. Purity: 0.96. IUPACName: disodium;[(2R,3S,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-2-(hydroxymethyl)oxolan-3-yl]phosphate. Canonical SMILES: C1C (C (OC1N2C=NC3=C2NC (=NC3=O)N)CO)OP (=O) ([O-])[O-]. [Na+]. [Na+]. Catalog: ACM102814039. | |
| 2'-Deoxyguanosine-5'-monophosphate | 2'-Deoxyguanosine-5'-monophosphate, a nucleotide molecule and a key player in DNA synthesis, holds immense potential in the development of antiviral drugs as well as in treating various cancers. This biochemical marker is additionally crucial in detecting and measuring DNA damage, a necessary step in studying the complex mechanisms of DNA replication and repair. Synonyms: 2'-Deoxyguanylic acid; dGMP; Deoxyguanylic acid; Deoxy-GMP; 2'-Deoxyguanosine 5'-phosphate; Deoxyguanosine 5'-monophosphate; 2'-Deoxy-GMP; 2'-Deoxy-5'-guanylic acid; Guanosine, 2'-deoxy-, 5'-(dihydrogen phosphate); 2'-Desoxyguanosine 5'-(dihydrogen phosphate); 9-(2-Deoxy-5-O-phosphono-β-D-erythro-pentofuranosyl)-2-imino-3,9-dihydro-2H-purin-6-ol. Grades: ≥98% by HPLC. CAS No. 902-04-5. Molecular formula: C10H14N5O7P. Mole weight: 347.22. | |
| 2'-O-Methylguanosine 5'-monophosphate triethylammonium salt | 2'-O-Methylguanosine 5'-monophosphate triethylammonium salt is a critical compound extensively used in the biomedical industry. It plays a crucial role in the treatment and research of various diseases, including viral infections, cancer, and neurological disorders. This product contributes to the development of targeted therapies and is an essential component in nucleic acid-based drug formulations. Its high purity and quality make it a valuable tool for biomedical research and drug discovery. Synonyms: 2'-O-Methyl-5'-guanylic acid; 2'-O-Mgmp; 2'-O-Methylguanosine 5'-monophosphate; [(2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxy-4-methoxyoxolan-2-yl]methyl dihydrogen phosphate. Grades: ≥ 95%. CAS No. 24121-01-5. Molecular formula: C11H16N5O8P. Mole weight: 377.25. | |
| 5'-Phosphoryl-(3'-amino-3'-deoxyguanylyl)-(3'-5')-3'-amino-3'-deoxycytidine | 5'-Phosphoryl-(3'-amino-3'-deoxyguanylyl)-(3'-5')-3'-amino-3'-deoxycytidine is a highly significant compound extensively employed in the biomedical sector, holding immense therapeutic potential for research of viral infections. Moreover, this remarkable compound exhibits auspicious outcomes in impeding the proliferation of neoplastic cells. Synonyms: [(2R,3S,4R,5R)-4-Amino-2-[[(2R,3S,4R,5R)-4-amino-5-(4-amino-2-oxo-pyri midin-1-yl)-3-phosphonooxy-oxolan-2-yl]methoxymethyl]-5-(2-amino-6-oxo-3H-purin-9-yl)oxolan-3-yl]oxyphosphonic acid; 5'-Guanylic acid,3'-amino-3'-deoxycytidylyl-(5'-3')-3'-amino-3'-deoxy; Padgdc. CAS No. 109679-54-1. Molecular formula: C19H28N10O13P2. Mole weight: 666.43. | |
| (7R,8S,9S)-Trihydroxy-10S(N2-deoxyguanosyl-3'-phosphate)-7,8,9,10-tetrahydrobenzo[a]pyrene Triethylamine | A metabolite of the environmental carcinogen benzo(a)pyrene, which is a benzopyrene-DNA adduct formed during subchronic dietary exposure to carcinogen benzo(a)pyrene (BaP). Synonyms: [7R-(7α, 8β, 9α, 10α)]-2'-Deoxy-N-(7, 8, 9, 10-tetrahydro-7, 8, 9-trihydroxybenzo[a]pyren-10-yl)-3'-guanylic Acid. Molecular formula: C36H43N6O10P. Mole weight: 750.73. | |
| 8-Hydroxydeoxyguanosine 5'-monophosphate sodium salt | 8-Hydroxydeoxyguanosine 5'-monophosphate sodium salt is an indispensable resource, playing a pivotal role in probing intricate oxidative DNA impairment and mending mechanisms. It finds extensive utility in uncovering the ramifications inflicted by reactive oxygen species on afflictions like cancer and neurodegenerative ailments. Synonyms: 5'-Guanylic acid, 2'-deoxy-7,8-dihydro-8-oxo-, sodium salt (1:2). CAS No. 1679384-24-7. Molecular formula: C10H14N5O8P.2Na. Mole weight: 409.2. | |
| c-Di-GMP | c-diGMP is a bacterial second messenger and a STING ligand. Synonyms: 3'-Guanylic acid, guanylyl-(3'?5')-, cyclic nucleotide; 5GP-5GP; Cyclic di-3',5'-guanylate; Cyclic diguanylate; Cyclic diguanylate monophosphate; Cyclic-di-GMP. Grades: ≥95%. CAS No. 61093-23-0. Molecular formula: C20H24N10O14P2. Mole weight: 690.41. | |
| Disodium[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate | Heterocyclic Organic Compound. Alternative Names: Disodium guanylate, Sodium 5-guanylate, 5-GMP-Na2, AC1NB07Z, MolPort-001-560-962, 111036-20-5, AKOS000493527, AKOS003237988, AKOS003307678, 5-Guanylic acid disodium salt hexahydrate, I07-0020, dipotassium [5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate, disodium [5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate. CAS No. 111036-20-5. Molecular formula: C10H12N5Na2O8P. Mole weight: 407.184 g/mol. Purity: 0.96. IUPACName: disodium;[5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate. Catalog: ACM111036205. | |
| GMP | Guanosine 5'-monophosphate has been found to be useful in studies of modulation of glutamatergic neurotransmission. Synonyms: Guanosine-5'-monophosphate; 5'-Guanylic Acid. Grades: ≥ 95 % by HPLC. Molecular formula: C10H14N5O8P. Mole weight: 363.22. | |
| Guanosine-2'(3')-monophosphate disodium salt | Guanosine-2'(3')-monophosphate disodium salt, a remarkable biomedicine product, emerges as a potent weapon in combating a myriad of multifarious diseases. Its unrivaled prowess as a precursor to cyclic guanosine monophosphate, an integral second messenger orchestrating intricate cellular signaling pathways, renders it indispensable. Synonyms: Guanylic acid disodium salt; Guanosine 2'-3'-monophosphate disodium salt mixed Isomers; 2'-Guanylic acid, disodium salt; (2R,3R,4R,5R)-2-(2-amino-6-hydroxypurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxola n-3-yl dihydrogen phosphate, sodium salt, sodium salt. Grades: 98%. CAS No. 70347-42-1. Molecular formula: C10H12N5O8PNa2. Mole weight: 407.18. | |
| Guanosine-2'(&3')-monophosphate disodium salt (mixed isomers) | Guanosine-2'(&3')-monophosphate disodium salt (mixed isomers). Group: Biochemicals. Alternative Names: Guanylic acid disodium salt; Guanosine 2'-3'-monophosphate disodium salt mixed Isomers. Grades: Highly Purified. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| Guanosine 5'-monophosphate | Guanosine 5'-monophosphate is a purine ribonucleoside 5'-monophosphate having guanine as the nucleobase. It has a role as a metabolite, a biomarker, an Escherichia coli metabolite and a mouse metabolite. It is a guanosine 5'-phosphate and a purine ribonucleoside 5'-monophosphate. It is a conjugate acid of a guanosine 5'-monophosphate(2-). Guanosine 5'-monophosphate. A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature. Synonyms: 5-Guanylic Acid; 5'-GMP; GMP; Guanidine Monophosphate; Guanosine 5'-Phosphate; Guanosine 5'-Phosphoric Acid; Guanosine Monophosphate; Guanylic Acid. Grades: ≥95%. CAS No. 85-32-5. Molecular formula: C10H14N5O8P. Mole weight: 363.22. | |
| Guanosine 5'-monophosphate calcium salt | Calcium guanylate is a compound with formula Ca(C10H12O4N5PO4). It is the calcium salt of guanylic acid. As a food additive, it is used as a flavor enhancer and has the E number E629. Synonyms: Calcium 5'-guanylate; Guanylic acid calcium salt; calcium,[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate; 5'-Guanylic acid calcium salt; Calcium guanylate; Calcium 5'-O-phosphonatoguanosine. Grades: ≥ 95%. CAS No. 38966-30-2. Molecular formula: C10H12CaN5O8P. Mole weight: 401.28. | |
| Guanosine 5'-monophosphate disodium salt | Disodium guanylate, also known as sodium 5'-guanylate and disodium 5'-guanylate, is a natural sodium salt of the flavor enhancing nucleotide guanosine monophosphate (GMP). Disodium guanylate is a food additive with the E number E627. It is commonly used in conjunction with glutamic acid (monosodium glutamate, MSG). As it is a fairly expensive additive, it is not used independently of glutamic acid; if disodium guanylate is present in a list of ingredients but MSG does not appear to be, it is likely that glutamic acid is provided as part of another ingredient such as a processed soy protein complex. It is often added to foods in conjunction with disodium inosinate; the combination is known as disodium 5'-ribonucleotides. Disodium guanylate is produced from dried seaweed and is often added to instant noodles, potato chips and other snacks, savory rice, tinned vegetables, cured meats, and packaged soup. Synonyms: Disodium guanylate; Disodium GMP; Disodium 5'-gmp; GMP disodium salt; 5'-Gmp disodium salt; Disodium guanosine-5'-monophosphate; 5'-Guanylic acid disodium salt; Sodium 5'-guanylate; Guanosine 5'-phosphate disodium salt. Grades: 98%. CAS No. 5550-12-9. Molecular formula: C10H12N5O8P·2Na. Mole weight: 407.18. | |
| Guanosine 5'-Monophosphate Ester 6-Deoxytalose Sodium Salt | Guanosine 5'-Monophosphate Ester 6-Deoxytalose Sodium Salt is used in the synthetic preparation of nucleoside monophosphate sugars such as GMP-Fucose. Synonyms: 5'-Guanylic Acid Mono(6-deoxy-α-L-galactopyranosyl) Ester Sodium Salt. Molecular formula: C16H23N5NaO12P. Mole weight: 531.34. | |
| Guanosine 5'-O-(2-Thiodiphosphate) Trilithium Salt | Guanosine 5'-O-(2-Thiodiphosphate) Trilithium Salt is a GDP analog which could inhibits G-protein activation. Synonyms: 5'-Guanylic acid, monoanhydride with phosphorothioic acid, trilithium salt; EINECS 308-328-9; Guanosine 5'-O-(2-thiodiphosphate) trilithium salt; trilithium; [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dioxidophosphinothioyl phosphate; Guanosine 5'-[beta-thio]diphosphate trilithium salt; GDP-beta-S-Li3; GDPbetaS trilithium salt; Guanosine 5'-O-(2-Thiodiphosphate), Trilithium Salt; MFCD00057735; Guanosine 5-O-(2-thiodiphosphate)trilithium salt; Guanosine,5'-esterwith thiodiphosphoric acid([(ho)2p(o)]2s)(9ci); Guanosine 5'-[beta-thio]diphosphate trilithium salt, >=85% (HPLC), powder. CAS No. 97952-36-8. Molecular formula: C10H12Li3N5O10P2S. Mole weight: 477.07. | |
| hypoxanthine phosphoribosyltransferase | Guanine and 6-mercaptopurine can replace hypoxanthine. Group: Enzymes. Synonyms: IMP pyrophosphorylase; transphosphoribosidase; hypoxanthine-guanine phosphoribosyltransferase; guanine phosphoribosyltransferase; GPRT; HPRT; guanosine 5'-phosphate pyrophosphorylase; IMP-GMP pyrophosphorylase; HGPRTase; 6-hydroxypurine phosphoribosyltransferase; 6-mercaptopurine phosphoribosyltransferas. Enzyme Commission Number: EC 2.4.2.8. CAS No. 9016-12-0. HGPRT. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2691; hypoxanthine phosphoribosyltransferase; EC 2.4.2.8; 9016-12-0; IMP pyrophosphorylase; transphosphoribosidase; hypoxanthine-guanine phosphoribosyltransferase; guanine phosphoribosyltransferase; GPRT; HPRT; guanosine 5'-phosphate pyrophosphorylase; IMP-GMP pyrophosphorylase; HGPRTase; 6-hydroxypurine phosphoribosyltransferase; 6-mercaptopurine phosphoribosyltransferase; GMP pyrophosphorylase; guanine-hypoxanthine phosphoribosyltransferase; guanosine phosphoribosyltransferase; guanylate pyrophosphorylase; guanylic pyrophosphorylase; inosinate pyrophosphorylase; inosine 5'-phosphate pyrophosphorylase; inosinic acid pyrophosphorylase; inosinic pyrophosphorylase; 6-mercaptopurine phosphoribosyltransferase; purine-6-thiol phosphoribosyltransferase. Cat No: EXWM-2691. |  |
| Ribonuclease T2 from Aspergillus oryzae, Recombinant | Aspergillus oryzae Ribonuclease T2 is a member of the RNase T2 family of endonucleases that are present in a wide variety of microbial, plant and animal species. In contrast to Aspergillus oryzae Ribonuclease T1, which is an exclusively guanylic-acid specific endonuclease, all RNase T2-like enzymes are essentially base non-specific. However, RNase T2 endonucleases from different species can show slight base preferences. The fungal enzymes, including Aspargillus oryzae RNaseT2, show slight base preference in the following order: A>G>C, U. RNase T2 cleaves between the 3-phosphate residue of one base and the 5-OH residue of the adjacent nucleotide forming a 2, 3-cyclic phosphate intermediate followed by the generation of oligonucleotides with 3-phosphate residues. This enzyme is also used as a non-mammalian source of RNase in various applications. Group: Enzymes. Synonyms: Ribonuclease T2; RNase T2; Ribonuclease. Enzyme Commission Number: EC 3.1.27.1. Rnase. Mole weight: 36 kDa. Activity: ≥10,000 units per mg protein. Stability: Stable at 12-18 months at 2-8°C. Storage: Store at 2-8°C. Form: Lyophilized powder. Source: Pichia pastoris. Species: Aspergillus oryzae. Ribonuclease T2; RNase T2; Ribonuclease. Cat No: NATE-1930. | |
| 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic Acid Ethyl Ester | 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic Acid Ethyl Ester is used in various studies of stimulators of soluble guanylate cyclase. Group: Biochemicals. Grades: Highly Purified. CAS No. 256376-59-7. Pack Sizes: 5mg, 25mg. Molecular Formula: C16H14FN3O2. US Biological Life Sciences. | Worldwide |
| 2-Cl-ATP | 2-Cl-ATP is an agonist of P2Y purinoceptor that inhibits soluble guanylate cyclase. Synonyms: 2- Chloroadenosine- 5'- triphosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 49564-60-5. Molecular formula: C10H15ClN5O13P3 (free acid). Mole weight: 541.6 (free acid). | |
| 2-Cyclopropylcarbonyl-3-dimethylaminoacrylic Acid Methyl Ester | 2-Cyclopropylcarbonyl-3-dimethylaminoacrylic Acid Methyl Ester is an intermediate in the preparation of soluble guanylyl cyclase activators. Group: Biochemicals. Alternative Names: α -[ (Dimethylamino) methylene]- β-oxo-cyclopropanepropanoic Acid Methyl Ester;Methyl 2- (Cyclopropylcarbonyl) -3- (dimethylamino) acrylate; Methyl 2-(Cyclopropylcarbonyl)-3-(dimethylamino)prop-2-enoate. Grades: Highly Purified. CAS No. 340774-26-7. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| 2-MeS-ATP | 2-MeS-ATP is an agonist of P2Y purinoceptors that inhibits soluble guanylate cyclase. Uses: Purinergic agonists. Synonyms: 2- Methylthioadenosine- 5'- O- triphosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 43170-89-4. Molecular formula: C11H18N5O13P3S (free acid). Mole weight: 553.3 (free acid). | |
| 3-Cyano-2-oxo-propionic Acid Ethyl Ester Sodium Salt | 3-Cyano-2-oxo-propionic Acid Ethyl Ester Sodium Salt is used in the preparation of stimulators of soluble guanylate cyclase. Group: Biochemicals. Grades: Highly Purified. CAS No. 53544-13-1. Pack Sizes: 500mg, 1g. Molecular Formula: C6H6NNaO3, Molecular Weight: 163.11. US Biological Life Sciences. | Worldwide |
| 5-Hydroxy-2-adamantanone | 5-Hydroxy-2-adamantanone is used in the hydrosilylation of hydroxyketones. Also used in the preparation of adamantane substituted guanylhydrazones as inhibitors of butyrylcholinesterase, natural enzymes affecting succinic acid regulation. Group: Biochemicals. Alternative Names: 1-Hydroxy-4-adamantanone; 1-Hydroxy-4-ketoadamantane; 4-Oxo-1-adamantanol; 5-Hydroxy-2-adamantanone; 5-Hydroxyadamantanone; Idramantone; Kemantan; Kemantane; 5-Hydroxy-tricyclo[3.3.1.13, 7]decanone; 5-Hydroxytricyclo[3. 3. 1. 13, 7]decan-2-one. Grades: Highly Purified. CAS No. 20098-14-0. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-390 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-390, a luminescent marker, offers researchers a viable tool to evaluate cyclic nucleotide signaling pathways. It furnishes a mechanism to assay guanylyl cyclase action, as well as drug responsiveness. Moreover, its application has the potential for wider clinical utilization including drug delivery and cancer diagnosis. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 390, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C36H49N8O10P (free acid). Mole weight: 784.80 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-612Q | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-612Q, a fluorescent probe, designed to assist biomedical research in investigating guanylyl cyclase enzyme activity and cGMP-related signaling pathways, as well as studying the pathogenesis of cardiovascular diseases and cancer. The intricacies of this product are profound whilst remaining highly practical, offering a truly unique insight into its potential. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 612Q, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H24N7O7P - ATTO 612Q (free acid). Mole weight: 1131.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-647N | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-647N is a fluorescent probe used for imaging guanylyl cyclase and monitoring cGMP signaling pathways in biological systems. This product can also be utilized in the diagnosis and treatment of disorders related to the activation or inhibition of guanylyl cyclase and cGMP. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 647N, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O7P - ATTO 647N (free acid). Mole weight: 1086.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-740 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-740, a fluorescent probe, is a valuable tool in biomedical research for investigating the function of guanylyl cyclases and soluble guanylate cyclases. Notably, this versatile probe can be used to study the mechanisms underlying cardiovascular diseases and neuronal disorders, thereby offering the potential for significant scientific breakthroughs and medical advancements. Its reliability and efficacy make it a highly sought-after compound for researchers across diverse fields. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 740, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O7P - ATTO 740 (free acid). Mole weight: 908.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - DY-776 | DY-776, a potent and selective agonist of soluble guanylate cyclase (sGC), stands as a key target for treatment of pulmonary hypertension and other cardiovascular diseases. Operating through its heme-containing domain, the DY-776 compound effortlessly binds, exhibiting increases in cyclic guanosine monophosphate (cGMP) concentrations in smooth muscle cells facilitating the enhanced vasodilation and an improved blood flow. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with DY 776. Grades: ≥ 95% by HPLC. Molecular formula: C60H72N9O15PS2 (free acid). Mole weight: 1254.37 (free acid). | |
| Acylated Linaclotide | Linaclotide is a 14 amino acid peptide that is a guanylate cyclase C agonist.It is suitable for the treatment of adult CC and IBS-C. Molecular formula: C61H81N15O22S6. Mole weight: 1568.76. | |
| ADENYLYL-(3'-5')-GUANOSINE | ADENYLYL-(3'-5')-GUANOSINE, a fundamental molecule in cellular signaling pathways, is an indispensable regulator of intracellular communication. It assumes a pivotal position in the control of diverse biological phenomena encompassing DNA synthesis and repair, cell growth, as well as immune responses. In the realm of biomedicine, ADENYLYL-(3'-5')-GUANOSINE finds utility in the investigation of second messenger signaling, cyclic nucleotide regulation, and the therapeutic management of afflictions including cancer, cardiovascular disorders, and neurodegenerative conditions. Synonyms: Guanosine, adenylyl-(3'?5')-; 3'-Adenylic acid, 5'-ester with guanosine; Adenylyl-(3'?5')-guanosine; A-G; Adenosine, guanylyl-(5'?3')-; NSC 91554; ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl) hydrogen phosphate; 3'-O-(5'-Guanylyl)adenosine. Grades: ≥95%. CAS No. 3352-23-6. Molecular formula: C20H25N10O11P. Mole weight: 612.45. | |
| Aspartyl Linaclotide | Aspartyl Linaclotide is a 14 amino acid peptide that is a guanylate cyclase C agonist.It is suitable for the treatment of adult CC and IBS-C. Molecular formula: C59H78N14O22S6. Mole weight: 1527.71. | |
| Ataciguat | Ataciguat, formerly referred to as HMR-1766, a novel anthranilic acid derivative, is a potent guanylate cyclase activator. Ataciguat has potential to treat diseases associated with increased vascular tone combined with enhanced ROS production. Uses: Ataciguat, formerly referred to as hmr-1766, a novel anthranilic acid derivative, belongs to a new structural class of sgc activators capable of activating the oxidized form of sgc. ataciguat has been shown to improve endothelial function and to reduce p. Synonyms: HMR-1766; HMR 1766; HMR1766; Ataciguat; 5-Chloro-2-[[ (5-chloro-2-thienyl) sulfonyl]amino]-N-[4- (4-morpholinylsulfonyl) phenyl]benzamide; Ataciguat; HMR 1766. Grades: >98%. CAS No. 254877-67-3. Molecular formula: C21H19Cl2N3O6S3. Mole weight: 576.5. | |
| Atrial natriuretic factor (1-28) (human, porcine) | Atrial natriuretic factor (1-28) (human, porcine) is a 28 amino acid peptide corresponding to the rat protein sequence. It is an endogenous peptide synthesized in myoendocrine cells of the heart from which it is released into the circulation. It has effects on the renal and cardiovascular systems that decrease vasoconstriction, increase sodium excretion and inhibit renin secretion. It decreases plasma renin activity and cAMP levels in anesthetized rats and increases cGMP levels at 8 μg/kg. It also inhibits arginine vasopressin-induced increase in mean arterial blood pressure in spontaneously hypertensive and control rats when administered intracerebroventricularly at a dose of 150 ng. It produces diuretic, natriuretic and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure regulation. Synonyms: ANF 1-28; hANF; Atrial Natriuretic Peptide human. CAS No. 91917-63-4. Molecular formula: C127H205N45O39S3. Mole weight: 3080.46. | |
| BLP-1654 | BLP-1654 is a semi-synthetic penicillin made from 6-aminopenicillanic acid (6-APA). It has anti-Gram-positive and negative bacteria activity, especially for Pseudomonas bacteria. Synonyms: 6- (D-alpha- (3-Guanylureido) phenylacetamido) penicillanic acid. Grades: >98%. CAS No. 28889-87-4. Molecular formula: C18H22N6O5S. Mole weight: 434.47. | |
| Cinaciguat | An experimental drug as an an activator of sGC in an NO-independent manner (Kd = 3.2 nM). Uses: Soluble guanylate cyclase (sgc) activators. Synonyms: BAY 58-2667; BAY 582667; BAY-58-2667; BAY582667 4-((4-carboxybutyl)(2-((4-phenethylbenzol) oxy)phenethyl)amino)methyl(benzoic) acid. Grades: ≥98.0%. CAS No. 329773-35-5. Molecular formula: C36H39NO5. Mole weight: 565.70. | |
| Creatine, anhydrous | Creatine, anhydrous. Group: Biochemicals. Alternative Names: N-(Aminoiminomethyl)-N-methylglycine; 2-(1-Methylguanidino)acetic Acid; Cosmocair C 100; Kre-Alkalyn; Methylguanidoacetic Acid; N-Methyl-N-guanylglycine; NSC 8752; Neotine; Phosphagen; Tego Cosmo C 100; [N-(Amidino)-N-methylamino]acetic Acid. Grades: Reagent Grade. CAS No. 57-00-1. Pack Sizes: 100g, 250g, 1Kg. Molecular Formula:?C?H?N?O?. US Biological Life Sciences. | Worldwide |
| CTPαS | CTPαS, a molecule activator of soluble guanylate cyclase (sGC), is vying for a preeminent position in the study of nitric oxide signaling pathway. With its therapeutic potential locked and loaded, CTPαS is turning heads in the scientific community, demonstrating potential efficacy in addressing cardiovascular diseases such as hypertension and pulmonary arterial hypertension, as well as a wide range of central nervous system conditions, including neurodegenerative diseases and pain management alike. Synonyms: Cytidine-5'-(α-thio)-triphosphate, Sodium salt (1 : 1 Mixture of Rp and Sp isomers). Grades: ≥ 95% by HPLC. Molecular formula: C9H16N3O13P3S (free acid). Mole weight: 499.21 (free acid). | |
| Des-Tyr(14)-Linaclotide | Des-Tyr(14)-Linaclotide is an impurity of Linaclotide, which is a peptide agonist of guanylate cyclase 2C used for the treatment of abdominal pain in patients with irritable bowel syndrome (IBS) associated with constipation. Synonyms: L-cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparagyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonyl-glycyl-L-cysteine (1->6),(2->10),(5->13)-tris(disulfide); H-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-OH (Disulfide bridge: Cys1-Cys6, Cys2-Cys10, Cys5-Cys13); (3S, 6R, 9S, 15R, 20R, 23S, 26S, 29R, 32R, 37R, 40S, 45aS)-32-amino-40-(2-amino-2-oxoethyl)-26-(2-carboxyethyl)-23-(4-hydroxybenzyl)-9-((R)-1-hydroxyethyl)-3-methyl-1, 4, 7, 10, 13, 22, 25, 28, 31, 38, 41, 47-dodecaoxotetracontahydro-19H-37, 20-(epiminomethano)-6, 29-(methanodithiomethano)pyrrolo[2, 1-s][1, 2, 27, 28]tetrathia[5, 8, 11, 14, 17, 20, 23, 32, 35, 38, 41]undecaazacyclotritetracontine-15-carboxylic acid; Linaclotide metabolite MM 419447; MM 419447; SP 340; L-Cysteine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-, cyclic (1?6),(2?10),(5?13)-tris(disulfide). CAS No. 1092457-78-7. Molecular formula: C50H70N14O19S6. Mole weight: 1363.55. | |
| Guanosine 3',5'-cyclic monophosphate | Cyclic guanosine monophosphate (Cyclic GMP) is a guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'-and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. 3',5'-cyclic GMP is a 3',5'-cyclic purine nucleotide in which the purine nucleobase is specified as guanidine. It has a role as a plant metabolite, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a guanyl ribonucleotide and a 3',5'-cyclic purine nucleotide. It is a conjugate acid of a 3',5'-cyclic GMP(1-). Synonyms: D-Guanosine 3',5'-cyclic monophosphate; 3',5'-cyclic GMP; 2-Amino-6-oxo-6,9-dihydro-1H-purine 3-oxide; guanine-3-N-oxide; 2-Amino-1,7-dihydro-6H-purin-6-one 3-oxide; Cyclic guanosine monophosphate; 9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-1H-purin-6-one. Grades: ≥ 95%. CAS No. 7665-99-8. Molecular formula: C10H12N5O7P. Mole weight: 345.21. | |
| Guanosine-5'-carboxylic acid | Guanosine-5'-carboxylic acid, a pivotal component in the realm of biomedicine, holds immense importance. Its primary role revolves around the exploration and innovation of antiviral pharmaceuticals, with a specific focus on tackling herpes simplex and varicella-zoster viruses. By serving as a fundamental cornerstone for the synthesis of robust antiviral agents, this compound actively drives significant progress in the treatment landscape of viral ailments. Synonyms: 1-(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)-1-deoxy-b-D-ribofuranuronic acid; (2S,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydro-2-furancarboxylic acid; 5'-Guanylsaeure; guanosine-5'-carboxylic acid; 1-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-β-D-1-deoxy-ribofuranuronic acid. Grades: ≥ 95%. CAS No. 15596-14-2. Molecular formula: C10H11N5O6. Mole weight: 297.22. | |
| Guanylurea sulfate | Guanylurea sulfate. Group: other glass and ceramic materials. Alternative Names: diaminomethylideneurea,sulfuric acid. CAS No. 591-01-5. Product ID: diaminomethylideneurea; sulfuric acid. Molecular formula: 302.27. Mole weight: C4< / sub>H12< / sub>N8< / sub>O2< / sub>. H2< / sub>SO4< / sub>. IATXFPUBPMZBPH-UHFFFAOYSA-N. 98%. |  |
| Guanylyl-3'-5'-adenosine triethylammonium salt | Guanylyl-3'-5'-adenosine triethylammonium salt is a versatile biomedical compound employed extensively within the pharmaceutical sector, emerging as a pivotal substrate for the esteemed guanylyl cyclase enzymes. This quintessential compound finds widespread utilization in an array of fundamental biochemical and pharmacological investigations, encompassing the study of cyclic GMP signaling cascade, neuropeptide release and the inducement of smooth muscle relaxation. Synonyms: GpA. Molecular formula: C20H25N10O11P·xC6H15N. Mole weight: 612.45 (free acid). | |
| GUANYLYL 5-PHOSPHORAMIDATE AMMONIUM | Heterocyclic Organic Compound. Alternative Names: Guanosine 5 inverted exclamation marka-diphosphoramidate, Guanylyl 5 inverted exclamation marka-phosphoramidate ammonium salt, 113728-12-4. CAS No. 113728-12-4. Molecular formula: NULL. Mole weight: 442.22. Purity: 0.96. IUPACName: [[5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyphosphonamidic acid;azane. Canonical SMILES: C1=NC2=C (N1C3C (C (C (O3)COP (=O) (O)OP (=O) (N)O)O)O)NC (=NC2=O)N. N. Catalog: ACM113728124. | |
| MM-419447 (Linaclotide Metabolite) Trifluoroacetic acid | MM-419447 (Linaclotide Metabolite) Trifluoroacetic acid is a metabolite of Linaclotide, which is a peptide agonist of guanylate cyclase 2C used to treat abdominal pain associated with constipation in patients with irritable bowel syndrome (IBS). Synonyms: L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteine trifluoroacetic acid; L-Cysteine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-, trifluoroacetic acid (1:x); H-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-OH.TFA. Grades: 97%. Molecular formula: C50H76N14O19S6.xC2HF3O2. Mole weight: 1369.61 (free base). | |
| Nelociguat | Nelociguat is a soluble guanylate cyclase stimulator (sGC stimulator), which is a key enzyme in the nitric oxide (NO) signalling pathway. It is used for the treatment of pulmonary hypertension. It promotes vasodilation and inhibits smooth muscle proliferation, leukocyte recruitment, platelet aggregation and vascular remodelling through a number of downstream mechanisms. It was also used for erectile dysfunction and heart failure. It was developed by Bayer and was in clinic phase 2 trials with no progress. Uses: Nelociguat is used for the treatment of pulmonary hypertension. it was also used for erectile dysfunction and heart failure. Synonyms: BAY60-4552; Methyl [4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]carbamate; Carbamic acid, N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-, methyl ester; N-Desmethyl Riociguat. Grades: 98%. CAS No. 625115-52-8. Molecular formula: C19H17FN8O2. Mole weight: 408.39. | |
| N,N-Bis-boc-1-guanylpyrazole | N,N'-Bis-Boc-1-guanylpyrazole is used in the stereoselective synthesis of the bicyclic guanidine alkaloid (+)-monanchorin. Group: Biochemicals. Alternative Names: [[[ (1, 1-Dimethylethoxy) carbonyl]amino]-1H-pyrazol-1-ylmethylene]-carbamic Acid 1,1-Dimethylethyl Ester; [[[ (1, 1-Dimethylethoxy) carbonyl]amino]-1H-pyrazol-1-ylmethylene]carbamic Acid 1,1-Dimethylethyl Ester; 1-[N, N'-Di (tert-butoxycarbonyl) amidino]-1H-pyrazole; 1H-Pyrazole-1-N, N'-bis (tert-butoxycarbonyl) carboxamidine; N,N'-Bis(tert-butoxycarbonyl)-1-guanylpyrazole; N,N'-Bis(tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine; N,N'-Bis(tert-butoxycarbonyl)-1H-pyrazole-1-carboximidamide; N,N'-Bis-Boc-1-guanylpyrazole; N,N'-Di(tert-butyl)oxycarbonyl-1H-pyrazole-1-carboximidamide; N,N'-Di-Boc-1H-pyrazole-1-carboxamidine; N,N'-Di-boc-1H-pyrazole-1-carboximidamide; [[ (tert-Butoxycarbonyl)imino] (pyrazol-1-yl)methyl]carbamic Acid tert-Butyl Ester; tert-Butyl [ (tert-Butoxycarbonylimino) (pyrazol-1-yl)methyl]carbamate. Grades: Highly Purified. CAS No. 152120-54-2. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| Zinc protoporphyrin IX | Zinc protoporphyrin IX is an endogenous metabolite formed during heme biosynthesis and a heme oxygenase inhibitor. Heme oxygenase is the enzyme producing CO, which is an activator of guanylyl cyclase and shares some chemical and biological properties of NO. Zinc protoporphyrin IX has been shown to inactivates the NOS isoforms nNOS, iNOS, and eNOS(IC50 = 0.8, 4, and 5 μM, respectively). Synonyms: 7,12-Diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid, zinc complex; Zinc protoporphyrin-9; ZnPP; Zinc 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,23-diid-2-yl]propanoic acid; Zn-Protoporphyrin IX. CAS No. 15442-64-5. Molecular formula: C34H32N4O4Zn. Mole weight: 626.03. | |
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