Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Hemoglobin | Hemoglobin is a iron-containing protein in red blood cells with oxygen binding properties. Hemoglobin is an inducer of HO-1. Hemoglobin consits of heme, which binds to oxygen. Hemoglobin also transports other gases, such as carbon dioxide, nitric oxide, hydrogen sulfide and sulfide. Hemoglobin absorbs unneeded oxygen in tissues, as an antioxidant [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 9008-02-0. Pack Sizes: 250 mg; 500 mg; 1 g. Product ID: HY-P2995. |  |
| Hemoglobin S | Abnormality of Hemoglobin is the main cause of sickle cell disease (SCD). Hemoglobin can be used in the determination of fetal hemoglobin by time-resolved immunofluorescence assay [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 9035-22-7. Pack Sizes: 5 mg. Product ID: HY-P3180. | |
| Bovine Hemoglobin Powder | Bovine Hemoglobin Powder. |  CA, FL & NJ |
| Glycosylated Human Hemoglobin | Glycosylated hemoglobin is the name given to hemoglobin that has been modified by reaction with glucose or similar derivative of this sugar. As blood sugar levels are higher in diabetic patients than in normal individuals, the amount of glycosylated hemoglobin in diabetics can reach four times the value found under normal circumstances and thus the measurement of glycosylated hemoglobin can be used to assess how well the condition is being kept under control. The glycosylated hemoglobin that is found in blood consists of a varity of products, the major one being HbAlc. Studies on this derivative indicate that the sugar may exist as a stable ketimine or as an unstable aldimine, the conversion of one form to the other being achieved by an Amadori rearrangement. In HbAlc the glucose is attached to the N-terminal valine of the beta-chain. Group: Others. Synonyms: Glycosylated Hemoglobin; Human Hemoglobin; Hemoglobin. Purity: Free of unreacted hemoglobin. Storage: Store at -20° C. Form: Freeze-dried powder. Source: Human. Glycosylated Hemoglobin; Human Hemoglobin; Hemoglobin. Cat No: NATE-1877. |  |
| Native Bovine Hemoglobin | Hemoglobin is found in the erythrocytes of all vertebrates. It is a conjugated protein with the prosthetic group heme which contains iron. The heme group is involved with the transport of oxygen from the lungs to tissues, while the globin portion of hemoglobin plays a major role in transporting carbon dioxide from the tissues to the lungs. The iron in heme is in the ferrous state. In oxyhemoglobin, it is apparently still in the ferrous state, but the oxygen is loosely bound to it. The structure of the hemoglobin molecule has been extensively studied. Most of the mammalian hemoglobins are composed of four subunits, consisting of four peptide chains to each of which is attached a heme group. But, among the mammalian hemoglobins, there are structural differences in terms of the amino acid residues and their sequences in the polypeptide chains. The molecular weight of hemoglobin is about 66,000 and the iron content is about 0.34%. The principal applications for hemoglobin are as a substrate for proteases, in anemia diagnosis and as a marker during molecular weight determination. Group: Others. Synonyms: Hemoglobin; Bovine Hemoglobin. Purity: Approx. 100%. Storage: Store at -20° C. Form: Freeze-dried powder. Source: Bovine Erythrocytes. Species: Bovine. Hemoglobin; Bovine Hemoglobin. Cat No: NATE-1878. | |
| Native Human Oxyhemoglobin | Hemoglobin is found in the erythrocytes of all vertebrates. It is a conjugated protein with the prosthetic group heme which contains iron. The heme group is involved with the transport of oxygen from the lungs to tissues, while the globin portion of hemoglobin plays a major role in transporting carbon dioxide from the tissues to the lungs. The iron in heme is in the ferrous state. In oxyhemoglobin, it is apparently still in the ferrous state, but the oxygen is loosely bound to it. Group: Others. Synonyms: Oxyhemoglobin; hemoglobin; Human Oxyhemoglobin. Purity: 90% (biuret). Activity: At least 50 U/mg protein. Storage: Store at -20° C. Form: Freeze-dried powder. Source: Human Erythrocytes. Species: Human. Oxyhemoglobin; hemoglobin; Human Oxyhemoglobin. Cat No: NATE-1881. | |
| 2,2-Dimethylbutanoic Acid | 2,2-Dimethylbutyrate (DMB) is a potential treatment for thalassemia and hemoglobinopathies. Group: Biochemicals. Grades: Highly Purified. CAS No. 595-37-9. Pack Sizes: 10g, 25g. Molecular Formula: C6H12O2, Molecular Weight: 116.16. US Biological Life Sciences. |  Worldwide |
| 2,3-Diphospho-D-glyceric acid penta(cyclohexylammonium) salt | D-Glycerate 2,3-diphosphate (DPG), cofactor of both phosphoglyceric acid mutase and hemoglobin, may be used as a reference compound in analysis of blood cell (erythrocyte) glycolysic cycle metabolites. 2,3-diphosphoglycerate (DPG) may be used as a reference in assays that measure DPG levels to indicate the health status of erythrocytes/red blood cells (RBC). Applications: Used as a reference compound in analysis of blood cell (erythrocyte) glycolysic cycle metabolites. Group: Coenzymes. Synonyms: D-Glycerate 2,3-diphosphate pentacyclohexylamine salt. CAS No. 62868-79-5. Purity: ≥95%. Mole weight: 761.91. Appearance: Powder. Form: Solid. D-Glycerate 2,3-diphosphate pentacyclohexylamine salt; 2,3-Diphospho-D-glyceric acid penta(cyclohexylammonium) salt; 62868-79-5. Cat No: COEC-080. | |
| (2Z) ? -2-? (4-Ethenyl-? 1, ? 5-? dihydro-? 3-? methyl-? 5-? oxo-? 2H-? pyrrol-? 2-? ylidene) ? acetamide | (2Z)-2-(4-Ethenyl-1,5-dihydro-3-methyl-5-oxo-2H-pyrrol-2-ylidene)acetamide is a Bilirubin (B385300) oxidation end product that results from the oxidative degradation of heme and hemoglobin. It is hypothesized to be associated with diseases such as subarachnoid hemorrhage induced cerebral vasospasm, in addition to altering potassium channel activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 1634653-34-1. Pack Sizes: 500ug, 5mg. Molecular Formula: C9H10N2O2, Molecular Weight: 178.19. US Biological Life Sciences. | Worldwide |
| 3-(3,4-Dimethoxyphenyl)propanoic acid | 3-(3,4-Dimethoxyphenyl)propanoic acid is an orally active short-chain fatty acids (SCFAs). 3-(3,4-Dimethoxyphenyl)propanoic acid stimulates γ globin gene expression, erythropoiesis in vivo and is used for the β hemoglobinopathies and other anemias [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2107-70-2. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g. Product ID: HY-Y1620. | |
| 6-Hydroxyflavone | 6-Hydroxyflavone is an orally effective flavonoid compound. 6-Hydroxyflavone can inhibit LPS (HY-D1056) -induced NO production and has anti-inflammatory effects. 6-Hydroxyflavone promotes osteoblast differentiation by activating AKT , ERK 1/2 and JNK signaling pathways. 6-Hydroxyflavone has an inhibitory effect on bovine hemoglobin (BHb) glycosylation. 6-Hydroxyflavone has a kidney protective effect. In addition, 6-Hydroxyflavone enhances GABA-induced current through the Benzodiazepine sites of γ-aminobutyric acid (GABA A ) receptors. 6-Hydroxyflavone shows a clear preference for α2 - and α3 - subtypes, which play an anti-anxiety role [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Natural products. CAS No. 6665-83-4. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-N7110. | |
| Bilirubin | Bilirubin (formerly referred to as haematoidin) is a yellow compound that occurs in the normal catabolic pathway that breaks down heme in vertebrates. This catabolism is a necessary process in the bodys clearance of waste products that arise from the destruction of aged red blood cells. First the hemoglobin gets stripped of the heme molecule which thereafter passes through various processes of porphyrin catabolism, depending on the part of the body in which the breakdown occurs. For example, the molecules excreted in the urine differ from those in the feces. The production of biliverdin from heme is the first major step in the catabolic pathway, after which the enzyme biliverdin reductase performs the second step, producing bilirubin from biliverdin.Bilirubin is excreted in bile and urine, and elevated levels may indicate certain diseases. It is responsible for the yellow color of bruises and the yellow discoloration in jaundice. Its subsequent breakdown products, such as stercobilin, cause the brown color of feces. A different breakdown product, urobilin, is the main component of the straw-yellow color in urine.It has also been found in plants. Group: Heterocyclic organic compound. Alternative Names: Cholerythrin. CAS No. 635-65-4. Molecular formula: C33H36N4O6. Mole weight: 584.66. Appearance: Solid. Purity: 0.98. IUPACName: 3-[2-[[3-(2-Carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxopyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol- |  |
| Biliverdine | Biliverdineis a precursor of Bilirubin. Biliverdine is formed in the body from hemoglobin. The bile of amphibia and of birds contains Biliverdine only. Group: Biochemicals. Alternative Names: 3,18-Diethenyl-1,19,22,24-tetrahydro-2,7,13,17-tetrametyl-1,19-dioxo-21H-biline-8,12-dipropanoic Acid; Biliverdin; Biliverdin IXα; Dehydrobilirubin; NSC 62793; Oocyan; Protobiliverdin IXα; Uteroverdine; α-Biliverdin. Grades: Highly Purified. CAS No. 114-25-0. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| cathepsin T | Degrades azocasein and denatured hemoglobin; the only native protein on which it has been shown to act is tyrosine aminotransferase. Group: Enzymes. Enzyme Commission Number: EC 3.4.22.24. CAS No. 77464-86-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4198; cathepsin T; EC 3.4.22.24; 77464-86-9. Cat No: EXWM-4198. | |
| cis-Vaccenic acid | cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate [1] , acts a potential fetal hemoglobin inducer [2]. Uses: Scientific research. Group: Natural products. CAS No. 506-17-2. Pack Sizes: 25 mg (1.77 M * 0.05 mL in Ethanol); 50 mg (1.77 M * 0.1 mL in Ethanol); 100 mg (1.77 M * 0.2 mL in Ethanol). Product ID: HY-113427A. | |
| Coproporphyrin I dihydrochloride | Coproporphyrin I dihydrochlorideIt is an organic compound belonging to the class of porphyrins. It is a derivative of heme, an iron-containing molecule found in hemoglobin and other proteins. Coproporphyrin I dihydrochlorideOften used as a biomarker in the assessment of certain liver and metabolic diseases, especially those related to bile synthesis and transport. It can also be used as a reference standard for analytical chemistry and pharmacological research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 69477-27-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-W073080. | |
| Crovalimab | Crovalimab (SKY59; RO7112689) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2?nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab binds human FcRn with great affinity (KD: 17 μM at pH 6.0). Crovalimab can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: SKY59; RO7112689. CAS No. 1917321-26-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99965. | |
| Cucurbitacin D | Source from rhizomes of Hemsleya amabilis Diels. It might be a new therapeutic option for the treatment of endometrial and ovarian cancers, also may be a potential therapeutic agent for β-hemoglobinopathies, including sickle cell anemia and β-thalassemia. And it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells. Uses: Antitumor, resistance to chemical carcinogens, protect liver. Synonyms: 17-[(3E)-1,5-Dihydroxy-1,5-dimethyl-2-oxohex-3-en-1-yl]-2,16-dihydroxy-4,4,9,14-tetramethylestr-5-ene-3,11-dione. Grades: >98%. CAS No. 3877-86-9. Molecular formula: C30H44O7. Mole weight: 516.67. |  |
| Danicopan | Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with K d value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ACH-4471. CAS No. 1903768-17-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117930. | |
| Eculizumab | Eculizumab is a recombinant human IgG2/4κ monoclonal antibody used for the treatment of paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). Eculizumab acts as a terminal complement inhibitor that binds to the terminal complement component 5, or C5 and suppresses the complement cascade. Uses: The treatment of pnh and ahus. Synonyms: Soliris. CAS No. 219685-50-4. | |
| Efaproxiral | Allosteric modifier of hemoglobin (HB). Binds in the central water cavity of the Hb molecule causing a conformational change such that bound oxygen is released more readily. Antineoplastic adjunct (radiosensitizer). Group: Biochemicals. Alternative Names: 2-[4-[2-[(3,5-Dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methylpropanoic Acid; RSR 13. Grades: Highly Purified. CAS No. 131179-95-8. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| Efaproxiral | synthetic small molecule with radiosensitizing activity. Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. One use for efaproxiral is to increase the efficacy of certain chemotherapy drugs which have reduced efficacy against hypoxic tumours, and can thus be made more effective by increased offloading of oxygen into the tumour tissues. However, no benefit was seen for efaproxiral in phase III clinical trials. Synonyms: RSR13; RSR-13; RSR 13; Efaproxyn; NSC722758; (24 (35di methyl anilino) carbonyl methyl phenoxyl2 methyl proprionic acid sodium salt. CAS No. 131179-95-8. Molecular formula: C20H23NO4. Mole weight: 341.4. | |
| Efaproxiral Sodium | Efaproxiral, a synthetic allosteric modi?er of hemoglobinoxygen binding af?nity, has been shown to bind reversibly to hemoglobin, stabilizing the deoxyhemoglobin tetramer conformation to reduce its af?nity for oxygen. Synonyms: Efaproxiral sodium; 170787-99-2; RSR13 SODIUM; Sodium 2-(4-(2-((3,5-dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoate; Efaproxiral (sodium); Efaproxiral sodium [USAN]; RSR-13 SODIUM; 3L83QP52XI; 170787-99-2 (sodium); Efaproxyn; Efaproxiral sodium (USAN); Sodium 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methylpropanoate; Propanoic acid, 2-(4-(2-((3,5-dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methyl-, monosodium salt; Efaproxiral Sodium. Grades: >98%. CAS No. 170787-99-2. Molecular formula: C20H23NO4.Na. Mole weight: 363.38. | |
| Endoproteinase GluC from Staphylococcus aureus, Recombinant | Protease S. aureus V8 (Endoproteinase-Glu-C) specifically cleaves peptide bonds on the COOH-terminal side of either aspartic or glutamic acids. In the presence of ammonium, the enzyme specificity is limited to glutamic sites. It has a molecular weight of 27 kDa daltons and optimum pH's of 4.0 and 7.8 with hemoglobin as the substrate. Protease S. aureus V8 is inhibited by diisopropylfluorophosphate and monovalent anions such as F-, Cl-, CH3COO-and NO3. Enzyme activity is determined by the casein digestion assay described by Drapeau. Endoproteinase gluc (staphylococcus aureus protease v8) is a serine proteinase which selectively cleaves peptide bonds c-terminal to...tide identification. Group: Enzymes. Synonyms: EC 3.4.21.19; Staph aureus V8 Protease; Protease, Staph aureus (Endoproteinase Glu-C); Glutamyl endopeptidase; V8 proteinase, endoproteinase Glu-C; staphylococcal serine proteinase. CAS No. 66676-43-5. V8 Protease. Mole weight: 29849 daltons. Activity: 38.3 μmol/min/mg. Storage: at -20°C. Form: Supplied freeze-dried from a Tris-HCl and sodium chloride buffer. Source: Bacillus subtilis. Species: Staphylococcus aureus. EC 3.4.21.19; Staph aureus V8 Protease; Protease, Staph aureus (Endoproteinase Glu-C); Glutamyl endopeptidase; V8 proteinase, endoproteinase Glu-C; staphylococcal serine proteinase. Cat No: NATE-1270. | |
| FG-2216 | FG-2216 (IOX3) is a potent and orally active inhibitor of HIF prolyl hydroxylase-2 (PHD2) , with an IC 50 of 3.9 μM. FG-2216 induces robust erythropoietin and modest fetal hemoglobin in vivo [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IOX3; YM311. CAS No. 223387-75-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15641. | |
| GBT-440 | GBT-440 is a substituted benzaldehyde compound that can modulate sickle hemoglobin (HbS) for treatment of disorders. Uses: Hematologic agents. Synonyms: Voxelotor, GBT-440, GBT 440, GBT440, GTx-011, GTx011, GTx 011; 2-hydroxy-6-[[2-(2-propan-2-ylpyrazol-3-yl)pyridin-3-yl]methoxy]benzaldehyde; Hemoglobin Modulators-1. Grades: >98%. CAS No. 1446321-46-5. Molecular formula: C19H19N3O3. Mole weight: 337.37. | |
| Glycidamide | Glycidamide is the genotoxic metabolite of Acrylamide. Glycidamide can react with proteins, such as hemoglobin, or with DNA, and induces genotoxic effects [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Oxiranecarboxamide; 2,3-Epoxypropanamide. CAS No. 5694-00-8. Pack Sizes: 5 mg. Product ID: HY-119329. | |
| Guaiac gum | Gum guaiac is a tree resin and crude source of 2,5-di-(4-hydroxy-3-methoxyphenyl)-3,4-dimethylfuran (α-guaiaconic acid).[3] The phenolic α-guaiaconic acid acts as a colorimetric peroxidase substrate.[1][2][4] When reacted with an organic or inorganic oxidizing agent, the α-guaiaconic acid is oxidized to a blue-colored quinone. The guaiac reaction has been used to detect trace amounts of heme from hemoglobin in the presence of peroxide. The Nobles test can be performed using 67% (w/v) gum guaiac diluted in 96% ethanol to analyze the level of extracellular oxidase production [5]. Group: Biochemicals. Grades: Highly Purified. CAS No. 9000-29-7. Pack Sizes: 25g, 50g, 100g, 250g, 500g. US Biological Life Sciences. | Worldwide |
| HBD-26 | HBD-26 is isolated from Homo sapiens with antibacterial activity. Synonyms: Hemoglobin subunit delta-26. | |
| HBD-27 | HBD-27 is isolated from Homo sapiens with antibacterial activity. Synonyms: Hemoglobin subunit delta-27. | |
| HBD-28 | HBD-28 is isolated from Homo sapiens with antibacterial activity. Synonyms: Hemoglobin subunit delta-28. | |
| heme oxygenase (staphylobilin-producing) | This enzyme, which is found in pathogenic bacteria, is involved in an iron acquisition system that catabolizes the host's hemoglobin. The two enzymes from the bacterium Staphylococcus aureus, encoded by the isdG and isdI genes, produce 67.5 % and 56.2 % 5-oxo-Δ-bilirubin, respectively. Group: Enzymes. Synonyms: haem oxygenase (ambiguous); heme oxygenase (decyclizing) (ambiguous); heme oxidase (ambiguous); haem oxidase (ambiguous); heme oxygenase (ambiguous); isdG (gene name); isdI (gene name). Enzyme Commission Number: EC 1.14.99.48. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1058; heme oxygenase (staphylobilin-producing); EC 1.14.99.48; haem oxygenase (ambiguous); heme oxygenase (decyclizing) (ambiguous); heme oxidase (ambiguous); haem oxidase (ambiguous); heme oxygenase (ambiguous); isdG (gene name); isdI (gene name). Cat No: EXWM-1058. | |
| Hemin | Hemin. Synonyms: PROTOHEMIN IX;HEMATIN HYDROCHLORIDE;HEMIN;HEMIN, BOVINE;HEMIN CHLORIDE;HEMIN CHLORIDE BOVINE;HEMIN CHLORIDE PORCINE;HEMIN (EX PORCINE, BOVINE, EQUINE). CAS No. 16009-13-5. Pack Sizes: 1 kg. Product ID: CDF4-0137. Molecular formula: C34H31ClFeN4O4-. Category: Nutrients. Product Keywords: Food Ingredients; Nutrients; Hemin; CDF4-0137; 16009-13-5; C34H31ClFeN4O4-; 240-140-1; 16009-13-5. Purity: 0.98. Color: Black. EC Number: 240-140-1. Physical State: crystal. Solubility: 1.4 M NaOH: soluble25mg/mL. Melting Point: 300 °C. Product Description: Heme is a small molecule present either free or bound to hemoglobin in the bloodstream of mammals. This is an alternative source of iron within the host that contains a porphyrin ring containing a Fe2+ ion called hemin. |  |
| Hemopressin (human, mouse) acetate | Hemopressin (human, mouse) acetate, derived from the α1-chain of hemoglobin and originally isolated from rat brain homogenates, is a bioactive endogenous peptide substrate for endopeptidase 24.15, neurolysin and ACE (Ki = 27.76, 3.43 and 1.87 μM, respectively). It acts as a selective CB1 receptor inverse agonist with antinociceptive and hypotensive activity. Synonyms: H-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH.CH3CO2H; L-prolyl-L-valyl-L-asparagyl-L-phenylalanyl-L-lysyl-L-leucyl-L-leucyl-L-seryl-L-histidine acetic acid. Grades: ≥95%. Molecular formula: C52H83N13O14. Mole weight: 1114.29. | |
| Hemopressin(rat) | Hemopressin(rat) is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin(rat) is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin(rat) exerts antinociceptive action in inflammatory pain models [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 568588-77-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1090. | |
| Hemorphin-7 | Hemorphin-7, a hemorphin peptide with antinociceptive and antihypertensive effects, is an endogenous opioid peptide derived from the β-chain of hemoglobin. Hemorphin peptides activates opioid receptors and inhibiting angiotensin-converting enzyme (ACE). The much lower affinity of hemorphin- 7 for μ-receptors as compared to other opioid peptides may be compensated by its much higher plasma concentration, resulting in biological effects of comparable magnitude. Synonyms: H-Tyr-Pro-Trp-Thr-Gln-Arg-Phe-OH; L-tyrosyl-L-prolyl-L-tryptophyl-L-threonyl-L-glutaminyl-L-arginyl-L-phenylalanine; L-Phenylalanine, N-(N2-(N2-(N-(N-(1-L-tyrosyl-L-prolyl)-L-tryptophyl)-L-threonyl)-L-glutaminyl)-L-arginyl)-. Grades: ≥97%. CAS No. 152685-85-3. Molecular formula: C49H64N12O11. Mole weight: 997.11. | |
| Hydroxyurea | Hydroxyurea is used as an inhibitor of DNA synthesis. As an anti-neoplastic, hydroxyurea inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide. Group: Biochemicals. Alternative Names: Carbamohydroxamic acid; N-Carbamoyl hydroxylamine; N-Hydroxyurea; Biosupressin; Carbamohydroxamic Acid; Carbamoyl Oxime; Cytodrox; Droxia; HU; Hidrix; Hydrea; Hydreia; Hydroxycarbamide; Hydroxycarbamine; N- (Aminocarbonyl) hydroxylamine; Hydroxylurea; Hydura; Hydurea; Litaler; Litalir; N-Carbamoyl hydroxylamine; NCI C04831; NSC 32065; Oxyurea; SK 22591; SQ 1089. Grades: Molecular Biology Grade. CAS No. 127-07-1. Pack Sizes: 10g, 25g, 100g, 250g, 500g. Molecular Formula: CH4N2O2, Molecular Weight: 76.06. US Biological Life Sciences. | Worldwide |
| Hydroxy Urea-13C,15N2 | Labeled Hydroxyurea. An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide. Group: Biochemicals. Alternative Names: N-Hydroxyurea-13C,15N2; Biosupressin-13C,15N2; Carbamohydroxamic Acid-13C,15N2; Carbamoyl Oxime-13C,15N2; Cytodrox-13C,15N2; Droxia-13C,15N2; Hydrea-13C,15N2; Hydreia-13C,15N2; Hydroxycarbamide-13C,15N2; Hydroxycarbamine-13C,15N2; N- (Aminocarbonyl) hydroxylamine-13C, 15N2; Hydroxylurea-13C,15N2; Hydura-13C,15N2; Litaler-13C,15N2; N-Carbamoylhydroxylamine-13C,15N2; NSC 32065-13C,15N2; Oxyurea-13C,15N2; SK 22591-13C,15N2; SQ 1089-13C,15N2. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Immobilized Pepsin on F7m | Pepsin is an endopeptidase. It hydrolyses proteins and peptides favorably adjacent to aromatic and dicarboxylic L-amino acid residues, preferentially phenylalanine and leucine but not next to valine, alanine, and glycine. Pepsin is not stable above pH 6. 0.F7m: 1. 0 mg pepsin (16 m Anson) immobilized on polyvinyl per CR-column (1 m Anson unit is equivalent to 1 umole of Foline-positive amino acids calculated as tyrosine released from denaturated hemoglobin per minute at 37. 5°C at pH 2; this mAnson unit is equivalentto ca. 180 D-A280 units). Nr. 40 Storage buffer : 50 mM glycine, 10% (v/v) glycerol, pH 4. 0Nr. 33 Reaction buffer: 20 mM Na acetate, pH 4. 7. Nr. 34 Washing buffer: 20 mM Na acetate, 1. 0 M NaCl, pH 4. 7. Group: Enzymes. Synonyms: EC 3. 4. 23. 1; pepsin; lactated pepsin; pepsin fortior; fundus-pepsin; elixir lactate of pepsin; P I; lactated pepsin elixir; P II; pepsin R; pepsin D; Pepsin A. Enzyme Commission Number: EC 3. 4. 23. 1. Storage: 4 °C. Source: Porcine mucosa. EC 3. 4. 23. 1; pepsin; lactated pepsin; pepsin fortior; fundus-pepsin; elixir lactate of pepsin; P I; lactated pepsin elixir; P II; pepsin R; pepsin D; Pepsin A; Immobilized Pepsin. Cat No: NATE-1766. | |
| Immobilized Pepsin on G3m | Pepsin is an endopeptidase. It hydrolyses proteins and peptides favorably adjacent to aromatic and dicarboxylic L-amino acid residues, preferentially phenylalanine and leucine but not next to valine, alanine, and glycine. Pepsin is not stable above pH 6. 0.G3m: 25 ug pepsin (0.4 m Anson) immobilized on dextran per CR-column, (1 m Anson unit is equivalent to 1 umole of Foline-positive amino acids calculated as tyrosine released from denaturated hemoglobin per minute at 37. 5°C at pH 2; this mAnson unit is equivalentto ca. 180 D-A280 units). Storage buffer: 50 mM glycine, 10% (v/v) glycerol, pH 4. 0Reaction buffer: 20 mM Na acetate, pH 4. 7. Washing buffer: 20 mM Na acetate, 1. 0 M NaCl, pH 4. 7. Group: Enzymes. Synonyms: EC 3. 4. 23. 1; pepsin; lactated pepsin; pepsin fortior; fundus-pepsin; elixir lactate of pepsin; P I; lactated pepsin elixir; P II; pepsin R; pepsin D; Pepsin A. Enzyme Commission Number: EC 3. 4. 23. 1. Storage: 4 °C. Source: Porcine mucosa. EC 3. 4. 23. 1; pepsin; lactated pepsin; pepsin fortior; fundus-pepsin; elixir lactate of pepsin; P I; lactated pepsin elixir; P II; pepsin R; pepsin D; Pepsin A; Immobilized Pepsin. Cat No: NATE-1767. | |
| legumain | Best known from legume seeds, the trematode Schistosoma mansoni and mammalian lysosomes. Not inhibited by compound E-64. Type example of peptidase family C13. Group: Enzymes. Synonyms: asparaginyl endopeptidase; citvac; proteinase B (ambiguous); hemoglobinase (ambiguous); PRSC1 gene product (Homo sapiens); vicilin peptidohydrolase; bean endopeptidase; vicilin peptidohydrolase. Enzyme Commission Number: EC 3.4.22.34. CAS No. 149371-18-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4209; legumain; EC 3.4.22.34; 149371-18-6; asparaginyl endopeptidase; citvac; proteinase B (ambiguous); hemoglobinase (ambiguous); PRSC1 gene product (Homo sapiens); vicilin peptidohydrolase; bean endopeptidase; vicilin peptidohydrolase. Cat No: EXWM-4209. | |
| Linoleic acid | Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 60-33-3. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-N0729. | |
| Linoleic acid-13C18 | Linoleic acid- 13 C 18 is the 13 C labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism [1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 287111-25-5. Pack Sizes: 500 μg; 1 mg. Product ID: HY-N0729S2. | |
| L-Threonine methyl ester hydrochloride | L-Threonine methyl ester is a protected form of L-Threonine. L-Threonine is an essential amino acid that is commonly used as a feed and food additive. L-Threonine is produced in mass quantities by mutant Escherichia coli strains for research and food nutrition purposes. L-Threonine can be naturally found in fish and poultry, and is incorporated in some important proteins in the human body (such as hemoglobin and insulin). Synonyms: L-Thr-OMe HCl; methyl(2S,3R)-2-amino-3-hydroxybutanoate hydrochloride; L-Threonine methyl ester hydrochloride. Grades: ≥ 98% (HPLC). CAS No. 39994-75-7. Molecular formula: C5H11NO3·HCl. Mole weight: 169.60. | |
| L-Threonine tert-butyl ester hydrochloride | L-Threonine tert-butyl ester is a protected form of L-Threonine. L-Threonine is an essential amino acid that is commonly used as a feed and food additive. L-Threonine is produced in mass quantities by mutant Escherichia coli strains for research and food nutrition purposes. L-Threonine can be naturally found in fish and poultry, and is incorporated in some important proteins in the human body (such as hemoglobin and insulin). Synonyms: L-Thr-OtBu HCl; (2S,3R)-tert-Butyl 2-amino-3-hydroxybutanoate hydrochloride; tert-butyl 2-amino-3-hydroxybutanoate hydrochloride. Grades: ≥ 99.9% (assay). CAS No. 69320-90-7. Molecular formula: C8H17NO3·HCl. Mole weight: 211.69. | |
| MeIQx | MeIQx, a dietary aromatic amine, is mutagenic compound could be isolated from present in fried beef and beef extracts. MeIQx binds covalently to hemoglobin. MeIQx induces liver tumors [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline-2. CAS No. 77500-04-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W355129. | |
| MK-8617 | MK-8617 is a potent and selective pan-inhibitor of Hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) (PHD1: IC50 = 1.0 nM; PHD2: IC50 =1.0nM; PHD3: IC50 = 14nM) commonly used for the treatment of Anemia, a disease caused by inadequate red blood cells (RBCs) or hemoglobin (Hb). Synonyms: MK-8617; MK 8617; MK8617; UNII-39RRC0G27V; 39RRC0G27V; SCHEMBL3407165; AKOS030622836; N-[bis(4-methoxyphenyl)methyl]-6-oxo-2-pyridazin-3-yl-1H-pyrimidine-5-carboxamide. Grades: 99.39 %. CAS No. 1187990-87-9. Molecular formula: C24H21N5O4. Mole weight: 443.45. | |
| myo-Inositol-d6 Trispyrophosphate Hexasodium Salt | Labeled myo-Inositol Trispyrophosphate hexasodium. A novel membrane-permeant allosteric effector of hemoglobin (Hb), enhances the regulated oxygen release capacity of red blood cells, thus counteracting the effects of hypoxia in diseases such as cancer and cardiovascular ailments. Group: Biochemicals. Alternative Names: ITTP-d6 Hexasodium Salt; myo-Inositol-d6 Cyclic 1,2:3,4:5,6-Tris(dihydrogen pyrophosphate)) Hexasodium Salt; myo-Inositol-d6 Cyclic 1,2:3,4:5,6-Tris(P,P'-dihydrogen diphosphate) Hexasodium Salt. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| myo-Inositol trispyrophosphate hexasodium | myo-Inositol trispyrophosphate (ITPP) hexasodium is a salt form of inositol triphosphate (ITPP). myo-Inositol trispyrophosphate (ITPP) hexasodium is a membrane-permeant hemoglobin allosteric regulator. myo-Inositol trispyrophosphate (ITPP) hexasodium enhances the oxygen release capacity of red blood cells by reducing the affinity of hemoglobin to oxygen. myo-Inositol trispyrophosphate (ITPP) hexasodium can be used in the study of cardiovascular disease and cancer [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ITPP hexasodium. CAS No. 23103-35-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141510. | |
| myo-Inositol Trispyrophosphate Hexasodium Salt | A novel membrane-permeant allosteric effector of hemoglobin (Hb), enhances the regulated oxygen release capacity of red blood cells, thus counteracting the effects of hypoxia in diseases such as cancer and cardiovascular ailments. Group: Biochemicals. Alternative Names: ITTP Hexasodium Salt; myo-Inositol Cyclic 1,2:3,4:5,6-Tris(dihydrogen pyrophosphate)) Hexasodium Salt; myo-Inositol Cyclic 1,2:3,4:5,6-Tris(P,P'-dihydrogen diphosphate) Hexasodium Salt. Grades: Highly Purified. CAS No. 23103-35-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Native Bovine Glutathione Peroxidase | Glutathione peroxidase is an enzyme which reduced lipid hydroperoxides into their corresponding alcohols. It also reduces free hydrogen peroxide in to water. In vivo it is responsible for protecting hemoglobin from oxidative breakdown. Applications: Glutathione peroxidase from bovine erythr ocytes was used as a positive control in cloning and characterization of full-length cdnas encoding two glutathione peroxidases (gpxs) from globodera rost ochiensis. it was used for the determination of glutathione peroxidase activity in human milk. Group: Enzymes. Synonyms: EC 1.11.1.9; GSH peroxidase; selenium-glutathione peroxidase; reduced glutathione peroxidase; 9013-66-5; GSH-Px, Glutathione:hydrogen-peroxide oxido-reductase; Glutathione Peroxidase. Enzyme Commission Number: EC 1.11.1.9. CAS No. 9013-66-5. Mole weight: mol wt 84.5 kDa. Activity: > 300 units/mg protein. Storage: -20°C. Form: Lyophilized powder containing 25% sucrose and 2.5% dithiothreitol with sodium phosphate buffer salts. Source: Bovine erythr ocytes. Species: Bovine. EC 1.11.1.9; GSH peroxidase; selenium-glutathione peroxidase; reduced glutathione peroxidase; 9013-66-5; GSH-Px, Glutathione:hydrogen-peroxide oxido-reductase; Glutathione Peroxidase. Cat No: NATE-0322. | |
| Native Human Glutathione Peroxidase | Glutathione peroxidase is an enzyme which reduced lipid hydroperoxides into their corresponding alcohols. It also reduces free hydrogen peroxide in to water. In vivo it is responsible for protecting hemoglobin from oxidative breakdown. At the reported ph optimum of 8.8, we have found the activity to be approx. 10 times that at ph 7.0. however, to remain consistent with literature and avoid complications arising from non-enzymatic oxidation of gsh, our unit is defined at ph 7.0. Group: Enzymes. Synonyms: EC 1.11.1.9; GSH peroxidase; selenium-glutathione peroxidase; reduced glutathione peroxidase; 9013-66-5; GSH-Px, Glutathione:hydrogen-peroxide oxido-reductase; Glutathione Peroxidase. Enzyme Commission Number: EC 1.11.1.9. CAS No. 9013-66-5. GSH-Px. Activity: > 30 units/mg protein. Storage: -20°C. Form: Lyophilized powder containing 25% sucrose, 3% dithiothreitol, and sodium phosphate buffer salts. Source: Human erythr ocytes. Species: Human. EC 1.11.1.9; GSH peroxidase; selenium-glutathione peroxidase; reduced glutathione peroxidase; 9013-66-5; GSH-Px, Glutathione:hydrogen-peroxide oxido-reductase; Glutathione Peroxidase. Cat No: NATE-0323. | |
| Native Human Myoglobin | Whereas hemoglobin is the carrier of oxygen, myoglobin stores oxygen in the tissues. Like hemoglobin, it also contains a noncovalently bound heme group. The molecule of myoglobin consists of a single polypeptide chain with molecular weight of 16,000 and sequence analysis shows that it has similarities with hemoglobin. Following myocardial infraction myoglobin is lost from cardiac muscle cells and its presence in serum may be used as a diagnostic indicator. Group: Others. Synonyms: Myoglobin; Human Myoglobin. Purity: 0.99. Storage: Store at -20° C. Form: Freeze-dried powder. Source: Human Heart/Muscle. Species: Human. Myoglobin; Human Myoglobin. Cat No: NATE-1880. | |
| Native Myrothecium verrucaria Bilirubin Oxidase | In enzymology, a bilirubin oxidase (EC 1.3.3.5) is an enzyme that catalyzes the chemical reaction:2 bilirubin + O2<-> 2 biliverdin + 2 H2O. Thus, the two substRates of this enzyme are bilirubin and O2, whereas its two products are biliverdin and H2O. This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-CH group of donor with oxygen as acceptor. This enzyme participates in porphyrin and chlorophyll metabolism. Applications: Bilirubin oxidase is used to degrade bilirubin. bilirubin oxidase, from myrothecium verrucaria, may be used to determine free hemoglobin in icteric specimens. it also has potential application in dye effluent decolorization and is a potential treatment for neonatal jaundice. Group: Enzymes. Synonyms: bilirubin oxidase M-1; EC 1.3.3.5; 80619-01-8; Bilirubin:oxygen oxidoreductase; Bilirubin Oxidase. Enzyme Commission Number: EC 1.3.3.5. CAS No. 80619-01-8. Bilirubin Oxidase. Activity: 15-65 units/mg protein. Storage: -20°C. Form: lyophilized powder. Source: Myrothecium verrucaria. bilirubin oxidase M-1; EC 1.3.3.5; 80619-01-8; Bilirubin:oxygen oxidoreductase; Bilirubin Oxidase. Cat No: NATE-0094. | |
| Native Staph aureus V8 Protease (Endoproteinase Glu-C) | Protease S. aureus V8 (Endoproteinase-Glu-C) specifically cleaves peptide bonds on the COOH-terminal side of either aspartic or glutamic acids. In the presence of ammonium, the enzyme specificity is limited to glutamic sites. It has a molecular weight of 27 kDa daltons and optimum pH's of 4.0 and 7.8 with hemoglobin as the substrate. Protease S. aureus V8 is inhibited by diisopropylfluorophosphate and monovalent anions such as F-, Cl-, CH3COO-and NO3. Enzyme activity is determined by the casein digestion assay described by Drapeau. Protease s. aureus v8 (endoproteinase-glu-c) specifically cleaves peptide bonds on the cooh-terminal side of either aspartic or glutamic acids. Group: Enzymes. Synonyms: EC 3.4.21.19; Staph aureus V8 Protease; Prot. Enzyme Commission Number: EC 3.4.21.19. CAS No. 137010-42-5. Purity: Chromatographically purified. V8 Protease. Mole weight: 27 kDa (Drapeau 1978). Activity: > 500 units per mg dry weight. Stability: Autolysis occurs at temperatures > 40°C. The enzyme is fully active in USP 0.2% SDS. Stable for 12 months at 2-8°C. Storage: Store at 2-8°C. Form: Lyophilized powder. Source: Staph aureus V8. EC 3.4.21.19; Staph aureus V8 Protease; Protease, Staph aureus (Endoproteinase Glu-C); Glutamyl endopeptidase; V8 proteinase, endoproteinase Glu-C; staphylococcal serine proteinase. Cat No: NATE-0730. | |
| Native Wheat germ Glutathione Reductase | Glutathione reductase (GR) is a crucial flavoenzyme in the antioxidant defense system. Reduced glutathione (GSH) is used by glutathione peroxidase to detoxify hydrogen peroxide and in the precess is converted to oxidized glutathione (GSSG). The GSSG is then recycled back to GSH by glutathione reductase (GR) using NADPH that is then converted to NADP+. The regenerated GSH is then available to detoxify more hydrogen peroxide. The enzyme uses FAD as a cofactor. GR and glutathione peroxidase may inhibit lipid peroxidation by functioning as antioxidant enzymes in sperm. Glutathione reductase shares a structural motif with a number of other proteins including aspartyl proteases, Citrate synthase, EF hands, hemoglobins, lipecalins, and α/β hydrolases. GR is stimulated by melatonin and is reportedly irreversibly inhibited by a number of oxygen radical generating systems. Group: Enzymes. Synonyms: EC 1.6.4.2; 9. Enzyme Commission Number: EC 1.6.4.2. CAS No. 9001-48-3. GR. Mole weight: mol wt 118 kDa. Activity: > 0.08 units/mg protein. Storage: -20°C. Source: Wheat germ. EC 1.6.4.2; 9001-48-3; Glutathione Reductase; GR; glutathione reductase; glutathione reductase (NADPH); NADPH-glutathione reductase; GSH reductase; GSSG reductase; NADPH-GSSG reductase; glutathione S-reductase; NADPH:oxidized-glutathione oxidoreductase. Cat No: NATE-0319. | |
| Pepstatin | Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC 50 s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: Pepstatin A. CAS No. 26305-03-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0018. | |
| Pepstatin | Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease. Group: Inhibitors. Alternative Names: ahpatininc; pepsininhibitors735a; procidins735a; PEPSTATIN; PEPSTATIN A;X-VAL-VAL-STATYL-ALA-STATIN;(3S,4S)-4-AMINO-3-HYDROXY-6-METHYL-HEPTANOIC ACID;AHMHA ISOVALERYL-L-VAL-L-VAL-AHMHA-L-ALA-STA. CAS No. 26305-03-3. Molecular formula: C34H63N5O9. Mole weight: 685.892. Appearance: Solid. Purity: 0.984. Density: 1.1±0.1 g/cm3. Catalog: ACM26305033. | |
| plasmepsin I | Known from the malaria organism, Plasmodium. About 37 kDa. In peptidase family A1 (pepsin A family), closest to cathepsin D and renin in structure. Inhibited by pepstatin. Formerly included in EC 3.4.23.6. Group: Enzymes. Synonyms: aspartic hemoglobinase I; PFAPG; malaria aspartic hemoglobinase. Enzyme Commission Number: EC 3.4.23.38. CAS No. 180189-87-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4274; plasmepsin I; EC 3.4.23.38; 180189-87-1; aspartic hemoglobinase I; PFAPG; malaria aspartic hemoglobinase. Cat No: EXWM-4274. | |
| plasmepsin II | Known from the malaria organism, Plasmodium. About 37 kDa. In peptidase family A1 (pepsin A family), and is 73% identical in sequence to plasmepsin I. Inhibited by pepstatin. Formerly included in EC 3.4.23.6. Group: Enzymes. Synonyms: aspartic hemoglobinase II; PFAPD. Enzyme Commission Number: EC 3.4.23.39. CAS No. 159447-18-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4275; plasmepsin II; EC 3.4.23.39; 159447-18-4; aspartic hemoglobinase II; PFAPD. Cat No: EXWM-4275. | |
| Pociredir | Pociredir (FTX-6058) is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). Pociredir can induce HbF protein expression in cell and murine models. Pociredir can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FTX-6058. CAS No. 2490676-18-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-139400. | |
| Pociredir hydrochloride | Pociredir (FTX-6058) hydrochloride is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). Pociredir hydrochloride can induce HbF protein expression in cell and murine models. Pociredir hydrochloride can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FTX-6058 hydrochloride. CAS No. 2490676-19-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139400A. | |
| Ravulizumab | Ravulizumab (ALXN1210) is a humanized monoclonal antibody that specifically binds with high affinity to the human complement protein C5. Ravulizumab can be used for the research of paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and myasthenia gravis [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ALXN1210. CAS No. 1803171-55-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99365. | |
| Rhodamine B hydrazide | Rhodamine B hydrazide is a water-soluble fluorescent probe used for the detection of copper, peroxynitrite, nitric oxide, hydrogen peroxide, glucose, diacetyl, and hemoglobin. Synonyms: 2-amino-3',6'-bis(diethylamino)-spiro[1H-isoindole-1,9'-[9H]xanthen]-3(2H)-one. Grades: ≥98%. CAS No. 74317-53-6. Molecular formula: C28H32N4O2. Mole weight: 456.6. | |
| RN 1 dihydrochloride | RN 1 is a potent lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 70 nM), which exhibits selectivity for LSD1 over MAO-A and MAO-B (IC50= 0.51 and 2.79 μM for MAO-A and MAO-B, respectively). It blocks long-term but not short-term memory in mice following intraperitoneal administration. RN-1 also induces cytotoxicity in ovarian cancer cell lines and induces fetal hemoglobin synthesis while reducing disease pathology in sickle cell mice. Synonyms: RN 1 dihydrochloride; RN-1 dihydrochloride; RN1 dihydrochloride; 1- (4-methyl-1-piperazinyl) -2-[[ (1R*, 2S*) -2-[4-phenylmethoxy) phenyl]cyclopropyl]amino]ethanone dihydrochloride; RN-1, monohydrochloride; RN-1 2HCl. Grades: ≥97% by HPLC. CAS No. 1781835-13-9. Molecular formula: C23H29N3O2.2HCl. Mole weight: 452.42. | |
| Sulfamethoxazole-NO | Sulfamethoxazole-NO (SMX-NO) is the major immunogen in sulfonamide allergy, producing modest ascorbic acid depletion and hemoglobin adduct formation. Sulfamethoxazole-NO haptens tissue proteins and is immunogenic in rodents [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SMX-NO. CAS No. 29699-89-6. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W587780. | |
| TN1 | TN1 is a potent fetal hemoglobin ( HbF ) inducer. Uses: Scientific research. Group: Signaling pathways. CAS No. 289479-94-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-100826. | |
| UNC0638 | UNC0638 selectively inhibits G9a and GLP histone methyltransferases with IC 50 of 15 nM and 19 nM, respectively. UNC0638 inhibits TNBC cell invasion and migration in vitro. UNC0638 is also an inhibitor of EHMT1/2 and induces fetal hemoglobin ( HbF ) expression in human erythroid progenitor cell culture. In addition, UNC0638 has anti- FMDV (foot-and-mouth disease virus) and anti- VSV (vesicular stomatitis virus) activities, with excellent potency and selectivity against multiple epigenetic and non-epigenetic targets [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1255580-76-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15273. | |
| Valorphin | Valorphin is an endogenous hemoglobin β-chain (33-39) fragment. Valorphin has opioid analgesic activity, binds to rat mu-opioid receptor, with an IC50 of 14 nM. Synonyms: H-Val-Val-Tyr-Pro-Trp-Thr-Gln-OH. Grades: 95%. CAS No. 144313-54-2. Molecular formula: C44H61N9O11. Mole weight: 892.01. | |
| Valorphin TFA | Valorphin TFA is an endogenous hemoglobin β-chain (33-39) fragment. It has opioid analgesic activity, and binds to rat mu-opioid receptor, with an IC50 of 14 nM. Synonyms: H-Val-Val-Tyr-Pro-Trp-Thr-Gln-OH.TFA; L-valyl-L-valyl-L-tyrosyl-L-prolyl-L-tryptophyl-L-threonyl-L-glutamine trifluoroacetic acid. Grades: ≥95%. Molecular formula: C46H62F3N9O13. Mole weight: 1006.03. | |
Our database is helping our users find suppliers everyday.
