Hexokinase Suppliers USA
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Product | Description | |
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Hexokinase II Inhibitor II, 3-BP - CAS 1113-59-3 Quick inquiry Where to buy Suppliers range | The Hexokinase II Inhibitor II, 3-BP, also referenced under CAS 1113-59-3, controls the biological activity of Hexokinase II. This small molecule/inhibitor is primarily used for Cell Structure applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1113-59-3. Pack Sizes: 100MG. Mole weight: 166.96. Catalog: AP1113593. Assay: ≥97% (titration). | |
2-Deoxy-2-fluoro-D-glucose Quick inquiry Where to buy Suppliers range | It is a substrate of hexokinase isozymes. Uses: Radiopharmaceuticals. Synonyms: 2-Deoxy-2-fluoro-D-glucopyranose; 2-Deoxy-2-fluoroglucose; FDG; Fludeoxyglucose; 2-Fluoro-2-deoxy-D-glucose. Grades: ≥95%. CAS No. 29702-43-0. Molecular formula: C6H11FO5. Mole weight: 182.15. | |
2-Deoxy-D-glucose Quick inquiry Where to buy Suppliers range | 2-deoxy-D-Glucose is a non-metabolizable glucose analog that inhibits phosphorylation of glucose by hexokinase, the first step of glycolysis. This results in the depletion in cellular ATP, the inhibition of protein glycosylation, and the disruption of ER quality control by inducing the unfolded protein response. 2-deoxy-D-Glucose has been shown to cause cell cycle inhibition and cell death in in vitro models of hypoxia, induce autophagy, increase reactive oxygen species production, activate AMPK, and block tumor cell growth in animal models. Synonyms: 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose; 2-DG; 2 DG; 2DG. Grades: >98%. CAS No. 154-17-6. Molecular formula: C6H12O5. Mole weight: 164.16. | |
ADP-4-deoxy-D-glucose Quick inquiry Where to buy Suppliers range | ADP-4-deoxy-D-glucose is a potent metabolic analog that inhibits hexokinase in glycolysis. Used in biomedical research, it aids in understanding the role of glucose metabolism in diseases such as cancer and diabetes. Synonyms: Adenosine diphospho-4-deoxy-a-D-glucose. | |
beta-D-Fructopyranose Quick inquiry Where to buy Suppliers range | Fructose, isolated from the leaves of Ginkgo biloba L, is transported into neocortical cells, including nerve terminals, and that it is metabolized and thereby detoxified primarily through hexokinase activity. High-Fructose intake induces nonalcoholic fatty liver disease (NAFLD) and chronic intermittent hypobaric hypoxia (CIHH) has beneficial effects on the body. Synonyms: beta-D-fructopyranose; Fructopyranose; FRUCTOSE HPLC; S(-)-FRUCTOSE; FRUCTOPYRANOSE,BETA-D-; (2R,3S,4R,5R)-2-(Hydroxymethyl)oxane-2,3,4,5-tetrol; Fructosteril; Frutabs. Grades: >98%. CAS No. 7660-25-5. Molecular formula: C6H12O6. Mole weight: 180.16. | |
Bromopyruvic acid Quick inquiry Where to buy Suppliers range | This active molecular is a synthetic brominated derivative of pyruvic acid which is a hexokinase II inhibitor and an effective antitumor agent because it is a highly reactive alkylating agent. The acute toxicity study provided an LD50 of 191.7 mg/kg for 3-BrPA in vivo. In 2010, Preclinical trials in Cancer in USA (Intra-arterial) for bromopyruvate was approved. In 2013, US FDA approved IND application for bromopyruvate in Liver cancer. Uses: Eliminating aggressive liver tumors. Synonyms: 3-bromo-2-oxopropanoic acid. Grades: 98 %. CAS No. 1113-59-3. Molecular formula: C3H3BrO3. Mole weight: 166.96. | |
D-Glucose 6-Phosphate Disodium Salt Hydrate Quick inquiry Where to buy Suppliers range | A phosphorylated glucose derivative that is a key intermediate in biological processes such as glycolysis, glycogenolysis, pentose phosphate pathway. At elevated levels inhibit brain hexokinase and glycolysis. Synonyms: D-Glucose 6-(Dihydrogen Phosphate) Disodium Salt Hydrate; D-Glucose 6-(Disodium Phosphate) Hydrate; Disodium D-Glucose 6-Phosphate Hydrate. Grades: 98%. Molecular formula: C6H11Na2O9P xH2O. Mole weight: 304.1. | |
Glycometabolism Compound Library Quick inquiry Where to buy Suppliers range | 708 glycometabolism-related comounds, can be used for HTS and HCT; - Targets contain GLUTs?Hexokinase?HK??Pyruvate Kinase?PK??phosphofructokinase?PFK??IDH1/2?LDH?AMPK, etc. ; - Detailed compound information with structure, target, and biological activity description; - NMR and HPLC/LCMS validated to ensure high purity and quality. - All compounds are in stock. Uses: Scientific use. Product Category: L2520. Categories: Glycometabolism Compounds Libraries. | |
Ketohexokinase Inhibitor (N8-(Cyclopropylmethyl)-N4-(2-(methylthio)phenyl)-2-(1-piperazinyl)-pyrimido[5,4-d]pyrimidine-4,8-diamine, KHK Inhibitor) Quick inquiry Where to buy Suppliers range | An orally bioavailable pyrimidinopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of human hepatic KHK activity (KHK-C isoform; IC50 = 12nM in a transcreener ADP assay) and efficiently blocks fructose-1-phosphate secretion (IC50 ≤ 400nM in HepG2 cells). Displays ~50-fold lower potency towards metabolic kinases, namely, ribokinase, hexokinase and adenosine kinase, and minimal binding affinities to diverse receptors and ion-channels, and excellent selectivity among a panel of 31-kinases including Akt1, AMPK, CaMKI/II, InsR, IRAK4, PKA and PKCtheta (IC50 >> 10uM). Shown to minimally affect the activities of human cytochrome p450 isozymes (1A2, 2C19, 2D6, 2C9 and 3A4), and exhibit high volume of distribution and high rate of clearance in rats. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?S 2HCl. US Biological Life Sciences. | Worldwide |
Lonidamine Quick inquiry Where to buy Suppliers range | mitochondrial hexokinase inhibitor. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 50264-69-2. Pack Sizes: 5MG, 25MG. Mole weight: 321.16. EC Number: 256-510-0. Catalog: AP50264692. | |
Metabolism Compound Library Quick inquiry Where to buy Suppliers range | A unique collection of 2350 metabolic pathway-related bioactive small molecule compounds for high-throughput, high-content screening. - Targeting multiple metabolic pathways such as gluconeogenesis, lipid metabolism, nucleotide metabolism; targets include GLUT, Hexokinase, Pyruvate Kinase; ATGL, MAGL, FAAH and other metabolism-related popular targets. - Structural diversity, significant drug potency and cell penetration. - Detailed specifications, compound structure, target information, activity description, etc. - NMR, HPLC/LCMS and other detection techniques to ensure correct structure and high purity of the product and reduce false positives. Uses: Scientific use. Product Category: L2560. Categories: Metabolism Compounds Libraries. | |
Mitochondria-Targeted Compound Library Quick inquiry Where to buy Suppliers range | A unique collection of 447 promising or approved mitochondria-targeted compounds including Idebenone, the only approved drug targeting mitochondria, for research in mitochondrial medicine; - Targets include mitochondria related targets, such as ATPase, mitochondria-associated hexokinase, Bcl-2, NADP, etc. and inhibitors for the autophagy initiating factor, ULK1, also include other promising mitochondria-targeted compounds such as lonidamine, paclitaxel, etc; - Bioactivity and safety confirmed by pre-clinical research and clinical trials; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L5300. Categories: Mitochondria-Targeted Compounds Libraries. | |
Ro 28-1675 Quick inquiry Where to buy Suppliers range | A cell-permeable thiazolyl-propanamide compound that acts as a glucokinase (GK) activator by increasing Vmax and decreasing [S]1/2 of GK-catalyzed reaction as well as freeing GK from the inhibitory action of GK regulatory protein (GKRP), resulting in increased. Induces GK nuclear-to-cytosol translocation in primary rat hepatocytes and reduces glucose concentration for insulin secretion stimulation from isolated rat pancreatic islets (threshold [glucose] = 3 mM vs 6 mM with or without 3 μM Ro-28-1675). Exhibits in vivo glucose-lowering and insulin-releasing activity in non-diabetic C57BL/6 mice and Wistar rats and is efficacious in several murine and rodent type II diabetes mellitus (T2DM) models (10 to 50 mg/kg via p.o.). Does not affect hexokinase I or II activity. Synonyms: RO28-1675; RO-28-1675; RO 28-1675; RO028-1675; RO-028-1675; RO 028-1675; RO281675; RO 281675; RO-281675; Ro 0281675; Ro-0281675; Ro0281675. Grades: >98%. CAS No. 300353-13-3. Molecular formula: C18H22N2O3S2. Mole weight: 378.51. | |
Suramin Quick inquiry Where to buy Suppliers range | Suramin, also called as Germanin, has been demonstrated to inhibit a large variety of enzymes including urease, hexokinase, succinic dehydrogenase, p-glucuronidase, acid phosphatase, lysozyme, thrombin, plasma kallikrein, (Na'-K')-activated ATPase, plasmi. Uses: Antineoplastic agents. Synonyms: suramin; Germanin; Naganol; Naphuride; Belganyl; Suramine. Grades: 95%. CAS No. 145-63-1. Molecular formula: C51H40N6O23S6. Mole weight: 1297.29. |