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| Product | Description | |
|---|---|---|
| 1-phosphatidylinositol-5-phosphate 4-kinase | This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, and regulation of actin cytoskeleton. Group: Enzymes. Synonyms: type II PIP kinase. Enzyme Commission Number: EC 2.7.1.149. CAS No. 247907-17-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2979; 1-phosphatidylinositol-5-phosphate 4-kinase; EC 2.7.1.149; 247907-17-1; type II PIP kinase. Cat No: EXWM-2979. |  |
| diphosphoinositol-pentakisphosphate kinase | This enzyme is activated by osmotic shock. Ins(1,3,4,5,6)P5, 1D-myo-inositol diphosphate tetrakisphosphate and 1D-myo-inositol bisdiphosphate triphosphate are not substrates. Group: Enzymes. Synonyms: PP-IP5 kinase; diphosphoinositol pentakisphosphate kinase; ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase; PP-InsP5 kinase; PPIP5K; PPIP5K1; PPIP5K2; VIP1; VIP2. Enzyme Commission Number: EC 2.7.4.24. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3206; diphosphoinositol-pentakisphosphate kinase; EC 2.7.4.24; PP-IP5 kinase; diphosphoinositol pentakisphosphate kinase; ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase; PP-InsP5 kinase; PPIP5K; PPIP5K1; PPIP5K2; VIP1; VIP2. Cat No: EXWM-3206. | |
| inositol-1,3,4-trisphosphate 5/6-kinase | In humans, this enzyme, along with EC 2.7.1.127 (inositol-trisphosphate 3-kinase), EC 2.7.1.140 (inositol-tetrakisphosphate 5-kinase) and EC 2.7.1.158 (inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP6). InsP6 is involved in many cellular processes, including mRNA export from the nucleus. Yeasts do not have this enzyme, so produce InsP6 from Ins(1,4,5)P3 by the actions of EC 2.7.1.151 (inositol-polyphosphate multikinase) and EC 2.7.1.158 (inositol-pentakisphosphate 2-kinase). Group: Enzymes. Synonyms: Ins(1,3,4)P3 5/6-kinase; inositol trisphosphate 5/6-kinase. Enzyme Commission Number: EC 2.7.1.159. CAS No. 288307-53-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2988; inositol-1,3,4-trisphosphate 5/6-kinase; EC 2.7.1.159; 288307-53-9; Ins(1,3,4)P3 5/6-kinase; inositol trisphosphate 5/6-kinase. Cat No: EXWM-2988. | |
| inositol 3-kinase | This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:myo-inositol 1-phosphotransferase. Other names in common use include inositol-1-kinase (phosphorylating), myoinositol kinase, and myo-inositol 1-kinase. This enzyme participates in inositol phosphate metabolism. Group: Enzymes. Synonyms: inositol-1-kinase (phosphorylating); myoinositol kinase; myo-inositol 1-kinase. Enzyme Commission Number: EC 2.7.1.64. CAS No. 37278-07-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3095; inositol 3-kinase; EC 2.7.1.64; 37278-07-2; inositol-1-kinase (phosphorylating); myoinositol kinase; myo-inositol 1-kinase. Cat No: EXWM-3095. | |
| inositol-hexakisphosphate kinase | Three mammalian isoforms are known to exist. Group: Enzymes. Synonyms: ATP:1D-myo-inositol-hexakisphosphate phosphotransferase; IP6K. Enzyme Commission Number: EC 2.7.4.21. CAS No. 176898-37-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3203; inositol-hexakisphosphate kinase; EC 2.7.4.21; 176898-37-6; ATP:1D-myo-inositol-hexakisphosphate phosphotransferase; IP6K. Cat No: EXWM-3203. | |
| inositol-pentakisphosphate 2-kinase | The enzyme can also use Ins(1,4,5,6)P4 and Ins(1,4,5)P3 as substrate. Inositol hexakisphosphate (phytate) accumulates in storage protein bodies during seed development and, when hydrolysed, releases stored nutrients to the developing seedling before the plant is capable of absorbing nutrients from its environment. Group: Enzymes. Synonyms: IP5 2-kinase; Gsl1p; Ipk1p; inositol polyphosphate kinase; inositol 1,3,4,5,6-pentakisphosphate 2-kinase; Ins(1,3,4,5,6)P5 2-kinase. Enzyme Commission Number: EC 2.7.1.158. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2987; inositol-pentakisphosphate 2-kinase; EC 2.7.1.158; IP5 2-kinase; Gsl1p; Ipk1p; inositol polyphosphate kinase; inositol 1,3,4,5,6-pentakisphosphate 2-kinase; Ins(1,3,4,5,6)P5 2-kinase. Cat No: EXWM-2987. | |
| inositol-polyphosphate multikinase | This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown. The enzyme from the plant Arabidopsis thaliana can also phosphorylate Ins(1,3,4,6)P4 and Ins(1,2,3,4,6)P5 at the D-5-position to produce 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate (InsP6), respectively. Yeast produce InsP6 from Ins(1,4,5)P3 by the actions of this enzyme and EC 2.7.1.158, inositol-pentakisphosphate 2-kinase. Group: Enzymes. Synonyms: IpK2; IP3/IP4 6-/3-kinase; IP3/IP4 dual-specificity 6-/3-kinase; IpmK; ArgRIII; AtIpk2α; AtIpk2β; inositol polyphosphate 6-/3-/5-kinase. Enzyme Commission Number: EC 2.7.1.151. CAS No. 9077-69-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2982; inositol-polyphosphate multikinase; EC 2.7.1.151; 9077-69-4; IpK2; IP3/IP4 6-/3-kinase; IP3/IP4 dual-specificity 6-/3-kinase; IpmK; ArgRIII; AtIpk2α; AtIpk2β; inositol polyphosphate 6-/3-/5-kinase. Cat No: EXWM-2982. | |
| inositol-tetrakisphosphate 1-kinase | This enzyme also phosphorylates Ins(1,3,4)P3 on O-5 and O-6. The phosphotransfer from ATP to either inositol 1,3,4-trisphosphate or inositol 3,4,5,6-tetrakisphosphate appears to be freely reversible to the extent that the enzyme can act like an inositol polyphosphate phosphatase in the presence of ADP. It can also catalyse an isomerization between Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP. Group: Enzymes. Synonyms: 1D-myo-inositol-tetrakisphosphate 1-kinase; inositol-trisphosphate 6-kinase; 1D-myo-inositol-trisphosphate 6-kinase; ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase; inositol-trisphosphate 5-kinase; 1D-myo-inositol-trisphosphate 5-kinase; ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase. Enzyme Commission Number: EC 2.7.1.134. CAS No. 187175-98-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2966; inositol-tetrakisphosphate 1-kinase; EC 2.7.1.134; 187175-98-0; 1D-myo-inositol-tetrakisphosphate 1-kinase; inositol-trisphosphate 6-kinase; 1D-myo-inositol-trisphosphate 6-kinase; ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase; inositol-trisphosphate 5-kinase; 1D-myo-inositol-trisphosphate 5-kinase; ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase. Cat No: EXWM-2966. | |
| inositol-tetrakisphosphate 5-kinase | The enzyme from plants and yeast can also use Ins(1,2,3,4,6)P5 as a substrate. Group: Enzymes. Synonyms: 1D-myo-inositol-tetrakisphosphate 5-kinase. Enzyme Commission Number: EC 2.7.1.140. CAS No. 123940-40-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2971; inositol-tetrakisphosphate 5-kinase; EC 2.7.1.140; 123940-40-9; 1D-myo-inositol-tetrakisphosphate 5-kinase. Cat No: EXWM-2971. | |
| inositol-trisphosphate 3-kinase | Activated by Ca2+. Three isoforms have been shown to exist. Group: Enzymes. Synonyms: 1D-myo-inositol-trisphosphate 3-kinase; Ins(1,4,5)P3 3-kinase. Enzyme Commission Number: EC 2.7.1.127. CAS No. 106283-10-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2963; inositol-trisphosphate 3-kinase; EC 2.7.1.127; 106283-10-7; 1D-myo-inositol-trisphosphate 3-kinase; Ins(1,4,5)P3 3-kinase. Cat No: EXWM-2963. | |
| 5-dehydro-2-deoxygluconokinase | This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:5-dehydro-2-deoxy-D-gluconate 6-phosphotransferase. Other names in common use include 5-keto-2-deoxygluconokinase, 5-keto-2-deoxyglucono kinase (phosphorylating), and DKH kinase. This enzyme participates in inositol metabolism. Group: Enzymes. Synonyms: 5-keto-2-deoxygluconokinase; 5-keto-2-deoxyglucono kinase (phosphorylating); DKH kinase. Enzyme Commission Number: EC 2.7.1.92. CAS No. 62213-35-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3122; 5-dehydro-2-deoxygluconokinase; EC 2.7.1.92; 62213-35-8; 5-keto-2-deoxygluconokinase; 5-keto-2-deoxyglucono kinase (phosphorylating); DKH kinase. Cat No: EXWM-3122. | |
| BAMB-4 | BAMB-4 is a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A((ITPKA). It exhibits the lowest inhibition frequency among the InsP3-Kinase inhibitors. It is a promising therapeutic approach in lung cancer therapy. Synonyms: Bamb-4; Bamb 4; Bamb4; ITPKA-IN-C14. Grades: >98%. CAS No. 891025-25-5. Molecular formula: C15H12N2O2. Mole weight: 252.27. |  |
| bpV(phen) potassium hydrate | BpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs) with IC50 of 38 nM. It also inhibits the vascular endothelial PTP-β with IC50 of 343 nM and PTP-1β with IC50 of 920 nM. At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5'-phosphatase-2. Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase. Synonyms: Bisperoxovanadium(phen); Potassium Bisperoxo(1,10-phenanthroline) oxovanadate (V). Grades: ≥98%. CAS No. 171202-16-7. Molecular formula: C12H8N2O5V·K+(H2O)3. Mole weight: 404.3. | |
| D-myo-Inositol-1,3,4,5,6-pentaphosphate ammonium salt | Inositol-1,3,4,5,6-pentaphosphateis one of the many inositol phosphate isomers that act as small, soluble second messengers in the transmission of cellular signals. It can be interconverted with Ins(3,4,5,6)P4 by a 1-kinase/1-phosphatase cycle, as well as with Ins(1,4,5,6)P4 in a 3-kinase/3-phosphatase cycle. Grades: >98%. Molecular formula: C6H7O21P5·10NH4. Mole weight: 750.36. | |
| D-myo-Inositol-1,3,4,5,6-pentaphosphate sodium salt | The phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway plays critical roles in cell growth and proliferation making it an attractive target for anticancer agents. Inositol-1,3,4,5,6-pentaphosphate (Ins(1,3,4,5,6)P5) is one of the many inositol phosphate isomers that act as small, soluble second messengers in the transmission of cellular signals. It exhibits antiangiogenic activity in vitro, blocking capillary tube formation of HUVEC, as well as antitumor effects against cancer xenografts in nude mice. Grades: ≥98%. Molecular formula: C6H12O21P5·5Na. Mole weight: 689.96. | |
| D-myo-Inositol-1,3,4,5-tetraphosphate sodium salt | D-myo-Inositol-1,3,4,5-tetraphosphate sodium salt is formed by the phosphorylation of Ins(1,4,5)P4 by inositol 1,4,5-triphosphate 3-kinase. Ins(1,3,4,5)P4 acts in conjunction with IP3 to mobilize intracellular calcium. Synonyms: D-myo-Inositol-1,3,4,5-tetrakis(phosphate) octasodium salt; Ins(1,3,4,5)P4 sodium salt. CAS No. 210488-61-2. Molecular formula: C6H8Na8O18P4. Mole weight: 675.93. | |
| D-myo-Inositol-1,3,4-triphosphate sodium salt | D-myo-Inositol-1,3,4-triphosphate (Ins(1,3,4)-P3) is one of several different inositol oligophosphate isomers implicated in signal transduction. Ins(1,3,4)-P3 acts through the inhibition of Ins(3,4,5,6)-P4 kinase activity to increase the cellular level of Ins(3,4,5,6)-P4 and thus inhibit calcium-activated chloride channels. Synonyms: D-myo-Inositol-1,3,5-triphosphate, sodium salt; 1,3,4-IP3 (sodium salt); 1,3,5-IP3 (sodium salt); HMS3650K09; Ins(1,3,5)P3 (sodium salt); Ins(1,3,4)-P3 (sodium salt); PD020265; D-myo-Inositol-1,3,4-triphosphate sodium salt. Grades: ≥98%. Molecular formula: C6H12Na3O15P3. Mole weight: 486.04. | |
| IP3(1,3,4) ammonium salt | IP3(1,3,4) ammonium salt is a chemical which occurs naturally in carbachol-stimulated rat parotid glands. Ins(1,3,4)P3 inhibits Ins(3,4,5,6)P4 1-kinase which regulates Ins(3,4,5,6)P4 levels. Synonyms: D-Myo-inositol-1,3,4-triphosphate (ammonium salt); rac-(1R,2R,3R,4R,5S,6S)-3,5,6-Trihydroxycyclohexane-1,2,4-triyl tris(dihydrogen phosphate), Triammonia Salt. Grades: >97%. CAS No. 1246355-66-7. Molecular formula: C6H24N3O15P3. Mole weight: 471.19. | |
| m-3M3FBS | m-3M3FBS is a direct activator of phospholipase C (PLC) that stimulates the increase in cytoplasmic calcium, inositol phosphate formation and superoxide generation in a variety of cell types. It is used in biological studies on Ca2+ homeostasis independently of phospholipase C activation. It is also used to study PLC signaling in cells and animals, often in conjunction with the PLC inhibitor U-73122. It has also been used for intracellular calcium analysis and MAP kinase assay in 293T cells. It also inhibits growth of the leukemic cell lines U937 and THP-1. Synonyms: m-3M3FBS; m 3M3FBS; m3M3FBS; 2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]-benzenesulfonamide; N-(3-Trifluoromethylphenyl)-2,4,6-trimethylbenzenesulfonamide. Grades: ≥99% by HPLC. CAS No. 200933-14-8. Molecular formula: C16H16F3NO2S. Mole weight: 343.36. | |
| phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase | This enzyme hydroylses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward (PtdIns(1,3,4,5)P4). The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects. Group: Enzymes. Synonyms: SHIP1; SHIP2; SHIP; p150Ship. Enzyme Commission Number: EC 3.1.3.86. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3692; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; EC 3.1.3.86; SHIP1; SHIP2; SHIP; p150Ship. Cat No: EXWM-3692. | |
| phosphoinositide phospholipase C | These enzymes form some of the cyclic phosphate Ins(cyclic1,2)P(4,5)P2 as well as Ins(1,4,5)P3. They show activity towards phosphatidylinositol, i.e., the activity of EC 4.6.1.13, phosphatidylinositol diacylglycerol-lyase, in vitro at high [Ca2+]. Four β-isoforms regulated by G-proteins, two γ-forms regulated by tyrosine kinases, four Δ-forms regulated at least in part by calcium and an ε-form, probably regulated by the oncogene ras, have been found. Group: Enzymes. Synonyms: triphosphoinositide phosphodiesterase; phosphoinositidase C; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase; monophosphatidylinositol phosphodiesterase; phosphatidylinositol phospholipase C; PI-PLC; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase. Enzyme Commission Number: EC 3.1.4.11. CAS No. 63551-76-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3711; phosphoinositide phospholipase C; EC 3.1.4.11; 63551-76-8; triphosphoinositide phosphodiesterase; phosphoinositidase C; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase; monophosphatidylinositol phosphodiesterase; phosphatidylinositol phospholipase C; PI-PLC; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase. Cat No: EXWM-3711. | |
| Phytic Acid, 50% Aqueous Solution | The principal storage form of phosphorus in many plant tissues, especially bran and seeds. It has antioxidant effect as well as neuroprotective effect by chelating iron. Inositol hexakisphosphate kinase type 2 (InsP6K2), which converts phytic acid to inositol pyrophosphate diphosphoinositol pentakisphosphate, is believed to induce pathogenesis of Huntington disease (HD). Group: Biochemicals. Alternative Names: myo-Inositol 1,2,3,4,5,6-Hexakis(dihydrogen phosphate); Alkalovert; Dermofeel PA 3; Exfoderm; Exfoderm Forte; Fytic Acid; IP6; Inositol 1,2,3,4,5,6-Hexakisphosphate; Inositol Hexakis(phosphate); Inositol hexaphosphate; InsP6; Phyliance; RP 3000; WHL; meso-Inositol hexaphosphate; myo-Inositol hexakis(phosphate); myo-Inositol hexaphosphate. Grades: Highly Purified. CAS No. 83-86-3. Pack Sizes: 25ml, 100ml, 250ml. Molecular Formula: C?H??O??P?, Molecular Weight: 660.04. US Biological Life Sciences. |  Worldwide |
| Phytic Acid Hexatriethylammonium Salt | The principal storage form of phosphorus in many plant tissues, especially bran and seeds. It has antioxidant effect as well as neuroprotective effect by chelating iron. Inositol hexakisphosphate kinase type 2 (InsP6K2), which converts phytic acid to inositol pyrophosphate diphosphoinositol pentakisphosphate, is believed to induce pathogenesis of Huntington disease (HD). Group: Biochemicals. Alternative Names: myo-Inositol 1,2,3,4,5,6-Hexakis(dihydrogen phosphate) Hexatriethylammonium Salt; Alkalovert Hexatriethylammonium Salt; Dermofeel PA 3 Hexatriethylammonium Salt; Exfoderm Hexatriethylammonium Salt; Exfoderm Forte Hexatriethylammonium Salt; Fytic Acid Hexatriethylammonium Salt; IP6; Inositol 1,2,3,4,5,6-Hexakisphosphate Hexatriethylammonium Salt; Inositol Hexakis(phosphate) Hexatriethylammonium Salt; Inositol hexaphosphate Hexatriethylammonium Salt; InsP6; Phyliance Hexatriethylammonium Salt; RP 3000 Hexatriethylammonium Salt; WHL Hexatriethylammonium Salt; meso-Inositol hexaphosphate Hexatriethylammonium Salt; myo-Inositol hexakis(phosphate) Hexatriethylammonium Salt; myo-Inositol hexaphosphate Hexatriethylammonium Salt. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| scyllo-inosamine 4-kinase | Also acts on streptamine, 2-deoxystreptamine and 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol. Group: Enzymes. Synonyms: scyllo-inosamine kinase (phosphorylating); scyllo-inosamine kinase; ATP:inosamine phosphotransferase. Enzyme Commission Number: EC 2.7.1.65. CAS No. 37278-08-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3096; scyllo-inosamine 4-kinase; EC 2.7.1.65; 37278-08-3; scyllo-inosamine kinase (phosphorylating); scyllo-inosamine kinase; ATP:inosamine phosphotransferase. Cat No: EXWM-3096. | |
| SH-5 | SH-5 is a potent and selective Src kinase inhibitor widely used in biomedical research on multiple diseases, including cancer, osteoporosis and cardiovascular disorders. Synonyms: SH-5, SH 5; SH5; PIA-5; PIA5; PIA 5; L-chiro-Inositol, 1-deoxy-6-O-methyl-, 5-[(2R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate]. Akt inhibitor II. Grades: 98%. CAS No. 701976-54-7. Molecular formula: C29H59O10P. Mole weight: 598.75. | |
| SH-5 (D-3-Deoxy-2-O-methyl-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate) | A cell-permeable inhibitor of Akt activation without affecting the activation of the upstream kinase PDK1 or other kinases downstream of Ras such as MAPK. Induces apoptosis and kills a variety of cancer cell lines containing high levels of active Akt. Group: Biochemicals. Alternative Names: D-3-Deoxy-2-O-methyl-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| SH-6 (D-2,3-Dideoxy-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate) | A cell-permeable inhibitor of Akt activation without affecting the activation of the upstream kinase PDK1 or other kinases downstream of Ras such as MAPK. Induces apoptosis and kills a variety of cancer cell lines containing high levels of active Akt. Group: Biochemicals. Alternative Names: D-2,3-Dideoxy-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Strontium Ranelate | Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate can also activate the calcium-sensing receptor (CaSR) in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activated protein kinase signaling [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Distrontium renelate; S12911. CAS No. 135459-87-9. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-17397. |  |
| TNP | TNP is a reversible and cell-permeable inhibitor of inositol hexakisphosphate kinase (IP6K) (IC50 = 0.47 μM for inhibition of InsP7 formation) and inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC50 = 10.2 μM). Synonyms: N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-Purine-2,6-diamine; IP3K Inhibitor; Inositol-1,4,5-trisphosphate 3-Kinase Inhibitor. Grades: ≥97% by HPLC. CAS No. 519178-28-0. Molecular formula: C20H16F3N7O2. Mole weight: 443.38. | |
| TNP (N6-[ (4-nitrophenyl) methyl]-N2-[[3- (trifluoromethyl) phenyl]methyl]-9H-Purine-2, 6-diami ne) | Reversible inositol hexakisphosphate kinase (IP6K) inhibitor (IC50 = 0.47um for inhibition of InsP7 formation). Also inhibits inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC50 = 10.2um). Binds to the ATP binding site of IP3K (Ki = 4.3um). Group: Biochemicals. Grades: Highly Purified. CAS No. 519178-28-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Valiolamine | Valiolamine is an exceptional alkaloid compound, used for studying chronic myeloid leukemia (CML). By virtue of its extraordinary capability to impede tyrosine kinases, Valiolamine demonstrates unparalleled potency in studying leukemic manifestations. Synonyms: D-epi-Inositol, 4-amino-3,4-dideoxy-2-C-(hydroxymethyl)-; 4-Amino-3,4-dideoxy-2-C-(hydroxymethyl)-D-epi-inositol; EB 0155. Grades: ≥95%. CAS No. 83465-22-9. Molecular formula: C7H15NO5. Mole weight: 193.20. | |
| Wortmannin | Antibiotic. Potent anti-neutrophil agent with cardioprotective effects. mTOR, DNA-PK, phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) inhibitor at high concentrations. Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K). Antitumor compound. Radiosensitizing agent. Adipogenesis inhibitor. Angiogenesis inhibitor. Autophagy inhibitor. DNA repair, receptor-mediated endocytosis and cell proliferation inhibitor. Potentiates the LPS-induced nitric oxide (NO) production from macrophages. Induces in vivo Alzheimer-like hyperphosphorylation in tau. Polo-like kinase family inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 19545-26-7. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C23H24O8. US Biological Life Sciences. | Worldwide |
| L-a-lysophosphatidyl inositol Sodium Salt, Soy (L-a-lysophosphatidyl inositol LPI, Lyso PI, Soy Lyso PI) | A potent agonist and assumed endogenous ligand of GPR55, shown to induce rapid phosphorylation of p38 mitogen-activated protein kinase (MAPK) and its downstream activating transcription factor 2 (ATF2) in both GPR55-transfected HEK293 cells, and in IM-9 lymphoblastoid cells naturally expressing GPR55 at 1uM, while having no effect on vector-transfected cells. In addition, shown to enhance serum induced cell migration in MCF-7 cells over expressing GPR55. Group: Biochemicals. Grades: Highly Purified. CAS No. 796963-91-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
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