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| Product | Description | |
|---|---|---|
| Integrin alpha-v-beta3 Antagonist, P11 (HSDVHK, HSDVHK-NH2) | A cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin avb3 (IC50=1.74pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37°C, a process which is mediated by caveolin and clathrin. At 10u/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50ug/ml. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| Integrin Antagonist 1 hydrochloride | Integrin Antagonist 1 hydrochloride, a naphthyridine derivative, is a small molecule antagonist of integrin αvβ6. Synonyms: RGD-mimetic-1; 1-Pyrrolidinebutanoic acid, β-[3-(3,5-dimethyl-1H-pyrazol-1-yl)phenyl]-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-, (βS,3R)- (hydrochloride). CAS No. 1629249-40-6. Molecular formula: C29H38ClN5O2. Mole weight: 524.10. |  |
| Integrin Antagonists 27 | Integrin Antagonists 27, as s novel anticancer agent., is a small molecule integrin αvβ3 antagonist. Uses: Anticancer agent. Synonyms: MDK-4976; Integrin Antagonist 27; MDK4976; MDK 4976; 3-{2-[(Z)-(1-{2-[(4-Methylphenyl)amino]-2-oxoethyl}-2,5-dioxo-4-imidazolidinylidene)methyl]-1H-pyrrol-1-yl}benzoic acid. Grades: ≥96%. CAS No. 593274-97-6. Molecular formula: C24H20N4O5. Mole weight: 444.44. | |
| Integrin Binding Peptide | Integrin Binding Peptide is a peptide containing the cell adhesion sequence RGDSP, which is easily conjugated to carriers via Npys or maleimide chemistry. Synonyms: Ac-Gly-Cys-Gly-Tyr-Gly-Arg-Gly-Asp-Ser-Pro-Gly-NH2; N-acetyl-glycyl-L-cysteinyl-glycyl-L-tyrosyl-glycyl-L-arginyl-glycyl-L-alpha-aspartyl-L-seryl-L-prolyl-glycinamide; Glycinamide, N-acetylglycyl-L-cysteinylglycyl-L-tyrosylglycyl-L-arginylglycyl-L-α-aspartyl-L-seryl-L-prolyl-. Grades: ≥95%. CAS No. 278792-07-7. Molecular formula: C42H63N15O16S. Mole weight: 1066.12. | |
| Integrin Binding Peptide | Integrin Binding Peptide is derived by fibronectin. Integrin Binding Peptide can be used for PEG hydrogel preparation [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 278792-07-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2532. |  |
| Integrin ?v?3 Antagonist, P11 | The Integrin ?v?3 Antagonist, P11 controls the biological activity of Integrin ?v?3. Group: Fluorescence/luminescence spectroscopy. |  |
| α2β1 Integrin Ligand Peptide acetate | α2β1 Integrin Ligand Peptide acetate is a potential antagonist of the α2β1 integrin receptor that interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors. Synonyms: DGEA acetate; H-Asp-Gly-Glu-Ala-OH acetate; a2b1 Integrin Recognition Sequence acetate; H-Asp-Gly-Glu-Ala-OH.CH3CO2H; L-alpha-aspartyl-glycyl-L-alpha-glutamyl-L-alanine acetic acid. Grades: ≥95%. CAS No. 2763588-78-7. Molecular formula: C16H26N4O11. Mole weight: 450.40. | |
| Anti-Integrin ?1 antibody, Mouse monoclonal | clone W1B10, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Integrin ?2b (CD41) antibody, Mouse monoclonal | clone PM6/248, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Integrin ?4 (ab2) antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Integrin ?4 (ab3) antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-phospho-Integrin ?1 (pThr789) antibody produced in rabbit | affinity isolated antibody. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-phospho-Integrin ?3 (pTyr773) antibody produced in rabbit | affinity isolated antibody. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-phospho-Integrin ?3 (pTyr785) antibody produced in rabbit | affinity isolated antibody. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-Integrin ?V antibody produced in mouse | 1 mg/mL, clone P2W7, tissue culture supernatant. Group: Fluorescence/luminescence spectroscopy. | |
| Vedolizumab (anti-α4β7-integrin) | Vedolizumab (anti-α4β7-integrin) is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 943609-66-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9911A. | |
| 12-HETE | 12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway [1].12-HETE has both anti-thrombotic and pro-thrombotic effects [2]. 12-HETE is a neuromodulator [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 71030-37-0. Pack Sizes: 50 μg (312.04 μM * 0.5 mL in Ethanol); 100 μg (312.04 μM * 1 mL in Ethanol). Product ID: HY-113439. | |
| 1-Chloroisoquinolin-6-amine | 1-Chloroisoquinolin-6-amine is a possible integrin expression inhibitor. It was also used to prepare heterocyclic compounds having sulfonamide groups as inhibitors of angiogenesis. Group: Biochemicals. Grades: Highly Purified. CAS No. 347146-33-2. Pack Sizes: 10mg, 25mg. Molecular Formula: C9H7ClN2, Molecular Weight: 178.62. US Biological Life Sciences. | Worldwide |
| 2-(2-Boc-aminoethoxy)ethanol | 2-(2-Boc-aminoethoxy)ethanol is a reactant that has been used in the synthesis of RGD-conjugated MEK1/2 kinase inhibitors for integrin-targeted cancer therapy. Group: Biochemicals. Grades: Highly Purified. CAS No. 139115-91-6. Pack Sizes: 1g, 5g. Molecular Formula: C9H19NO4. US Biological Life Sciences. | Worldwide |
| 2-[2- (Fmoc-amino) ethoxy]ethylamine Hydrochloride | 2-[2- (Fmoc-amino) ethoxy]ethylamine is an intermediate used to synthesize specific probes for human 5-HT4 receptor dimerization studies. It is also used to prepare doxorubicin-formaldehyde peptide conjugates targeting αv β3 integrin with antitumor activities. Group: Biochemicals. Grades: Highly Purified. CAS No. 221352-88-1. Pack Sizes: 25mg, 50mg. Molecular Formula: C19H23ClN2O3, Molecular Weight: 362.85. US Biological Life Sciences. | Worldwide |
| 2-Chloro-4-(methylamino)-benzoic Acid | 2-Chloro-4-(methylamino)-benzoic acid is used as a reagent to synthesize novel N-benzoyl-L-biphenylalanine derivatives that are potent inhibitors of α4 integrins. Group: Biochemicals. Grades: Highly Purified. CAS No. 3975-62-0. Pack Sizes: 25mg, 250mg. Molecular Formula: C8H8ClNO2, Molecular Weight: 185.61. US Biological Life Sciences. | Worldwide |
| (2R, ? 4R) ? -? 1-? Boc-? N-? Fmoc-? 4-? amino-? pyrrolidine-? 2-? carboxylic Acid | (2R, ? 4R) ? -? 1-? Boc-? N-? Fmoc-? 4-? amino-? pyrrolidine-? 2-? carboxylic Acid can be used as reactant/reagent in synthetic preparation of KMI-008 peptide derivatives and proline-based peptidomimetic analogs and determination of their activity as BACE1 inhibitors ( β-secretase inhibitors). It can also be used as reagent/reactant for preparation of aminoproline residues for solid phase synthesis of integrin binding cyclic peptides by bromination, azidation and protection / deprotection protocol. Group: Biochemicals. Grades: Highly Purified. CAS No. 1018332-24-5. Pack Sizes: 50mg, 100mg. Molecular Formula: C25H28N2O6, Molecular Weight: 452.5. US Biological Life Sciences. | Worldwide |
| (2S, 4S) -4-Amino-1, 2-pyrrolidinedicarboxyl ic Acid 1-(1,1-Dimethylethyl) Ester | (2S, 4S) -4-Amino-1, 2-pyrrolidinedicarboxyl ic Acid 1-(1,1-Dimethylethyl) Ester is used to prepare aminoproline residues for solid phase synthesis of integrin binding cyclic peptides. Group: Biochemicals. Grades: Highly Purified. CAS No. 132622-66-3. Pack Sizes: 500mg, 5g. Molecular Formula: C10H18N2O4, Molecular Weight: 230.26. US Biological Life Sciences. | Worldwide |
| Abituzumab | Abituzumab (DI17E6) is a humanised anti- integrin αV monoclonal antibody (IgG2 type). Abituzumab effectively reduces the phosphorylation of FAK , Akt and ERK. Abituzumab can be used in cancer research, particularly in prostate cancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: EMD 525797; DI17E6. CAS No. 1105038-73-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99183. | |
| Abituzumab | Abituzumab is a humanized anti-integrin αV monoclonal antibody developed for the treatment of prostate cancer metastatic. Abituzumab binds to αVβ3 and inhibits endothelial cell-cell interactions, endothelial cell-matrix interactions, and integrin-mediated tumor angiogenesis and metastasis in αVβ3-expressing tumor cells. Synonyms: EMD 525797; DI17E6. CAS No. 1105038-73-0. | |
| Abrilumab | Abrilumab is a fully human monoclonal antibody directed against α4β7. Abrilumab selectively binds the α4β7 integrin heterodimer. Abrilumab can be used for the research of inflammatory bowel disease (IBD) [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1342290-43-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99184. | |
| Arg-Gly-Asp | RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins. Synonyms: Arginyl-Glycyl-Aspartic acid; RGD peptide. Grades: Min 98%. CAS No. 99896-85-2. Molecular formula: C12H22N6O6. Mole weight: 346.34. | |
| Arg-Gly-Asp-Ser | Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. It is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. It inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor. It promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro. It also blocks the attachment of certain pathogens to cells. Uses: Platelet aggregation inhibitors. Synonyms: Arg Gly Asp Ser; RGDS peptide; Fibronectin Inhibitor. Grades: >98%. CAS No. 91037-65-9. Molecular formula: C15H27N7O8. Mole weight: 433.42. | |
| Arg-Gly-Asp-Ser acetate | Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. It is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. It inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor. It promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro. It also blocks the attachment of certain pathogens to cells. Molecular formula: C17H31N7O10. Mole weight: 493.47. | |
| ATN 161 | ATN-161 is a small peptide antagonist of integrin alpha5beta1 with potential antineoplastic activity. ATN-161 selectively binds to and blocks the receptor for integrin alpha5beta1, thereby preventing integrin alpha5beta1 binding. Synonyms: ATN161; ATN-161; Ac-PHSCN-NH2; N-acetyl-L-prolyl-L-histidyl-L-seryl-L-cysteinyl-L-asparaginamide. Grades: >98%. CAS No. 262438-43-7. Molecular formula: C23H35N9O8S. Mole weight: 597.65. | |
| ATN-161 trifluoroacetate salt | ATN-161 trifluoroacetate salt is a beta integrin antagonist with antitumor activity. It is a five -amino-acid peptide derived from the synergy region of fibronectin. It inhibited VEGF-induced migration and capillary tube formation in hCECs, but did not inhibit proliferation. Synonyms: ATN-161 TFA salt; ATN 161 TFA salt; ATN161 TFA salt. Grades: >98%. CAS No. 904763-27-5. Molecular formula: C25H36F3N9O10S. Mole weight: 711.67. | |
| β -? [ [ [4, ?5-Dihydro-?5-? [2-? (1H-?imidazol-?2-?ylamino) ?ethyl] ?-?3-?isoxazolyl] ?carbonyl] ?amino] ?-?3, ?4-?dihydro-?γ -?oxo-2 (1H) ?-?Isoquinolinebutanoic Acid | β-[[[4,?5-Dihydro-5-[2-(1H-imidazol-2-ylamino)?ethyl]?-3-isoxazolyl]?carbonyl]?amino]?-3,?4-dihydro-γ-oxo-2(1H)?-Isoquinolinebutanoic Acid is a derivative of isoxazole, which exhibits potential antagonistic activity for integrin receptor. Synonyms: 3-(5-(2-((1H-Imidazol-2-yl)amino)ethyl)-4,5-dihydroisoxazole-3-carboxamido)-4-(3,4-dihydroisoquinolin-2(1H)-yl)-4-oxobutanoic Acid. CAS No. 1230487-85-0. Molecular formula: C22H26N6O5. Mole weight: 454.48. | |
| Bexotegrast | Bexotegrast (PLN-74809) is an orally active, potent dual αvβ6/αvβ1 integrin inhibitor with K d of 5.7 nM and 3.4 nM, respectively. Bexotegrast inhibits αvβ6- and αvβ1-induced TGF-β activation with IC 50 values of 29.8 nM and 19.2 nM, respectively. Bexotegrast has antifibrogenic effects and block multiple avenues of TGF-β activation in the fibrotic lung [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PLN-74809. CAS No. 2376257-44-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137561. | |
| BIO 1211 | BIO 1211 is a selective and high affinity integrin α4β1 (Very Late Antigen 4; VLA-4) inhibitor with 200-fold selectivity for the activated form of α4β1 (KD = 70 pM; IC50=0.004 μM). Synonyms: BIO-1211; BIO1211. Grades: >98%. CAS No. 187735-94-0. Molecular formula: C36H48N6O9. Mole weight: 708.8. | |
| BIO5192 | BIO5192 is a selective and potent integrin α4β1 (VLA-4) inhibitor ( K d <10 pM). BIO5192 selectively binds to α4β1 ( IC 50 =1.8 nM) over a range of other integrins. BIO5192 results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 327613-57-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-107589. | |
| BIO 5192 | BIO 5192 is a selective and potent inhibitor of integrin α4β1 (Very Late Antigen-4; VLA-4) (Kd < 10 pM) with selectivity for α4β1 over a range of other integrins (IC50 values are 1.8, 138, 1053,> 500 and > 10,000 nM for α4β1, α9β1, α2β1, α4β7 and αIIbβ3, respectively). BIO 5192 causes a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels. Synonyms: BIO-5192; AMD-15057; BIO 5192; AMD 15057; BIO5192; AMD15057; (2S) -2- [ [ [ (2S) -1- [ (3, 5-Dichlorophenyl) sulfonyl] -2-pyrrolidinyl] carbonyl] amino] -4- [ [ (2S) -4-methyl-2- [methyl [2- [4- [ [ [ (2-methylphenyl) amino] carbonyl] amino] phenyl] acetyl] amino] -1-oxopentyl] amino] butanoic acid. Grades: ≥98% by HPLC. CAS No. 327613-57-0. Molecular formula: C38H46Cl2N6O8S. Mole weight: 817.78. | |
| Boc-β-alanine | Boc-β-alanine is a reagent used in the synthesis of quinazolines as platelet aggregation inhibitors and ligands of integrin. Synonyms: Boc-β-Ala-OH; 3-Boc-aminopropionic acid; Boc-beta-Ala-OH; Boc-beta-alanine; N-Boc-beta-alanine; Boc-b-Ala-OH; 3-((TERT-BUTOXYCARBONYL)AMINO)PROPANOIC ACID; N-(tert-butoxycarbonyl)-beta-alanine; N-t-BOC-beta-ALANINE; 3-(tert-butoxycarbonylamino)propanoic acid; n-tert-butoxycarbonyl-beta-alanine; N-((1,1-Dimethylethoxy)carbonyl)-beta-alanine; Boc beta Ala OH; 3-tert-Butoxycarbonylaminopropionic acid; 3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid; n-t-butyloxycarbonyl-beta-alanine. Grades: ≥ 98% (Assay). CAS No. 3303-84-2. Molecular formula: C8H15NO4. Mole weight: 189.20. | |
| Boc-beta-Ala-OH | Boc- β-Ala-OH is a reagent used in the synthesis of quinazolines as platelet aggregation inhibitors and ligands of integrin. Group: Biochemicals. Alternative Names: Boc- β-Ala- OH; BOC-3-aminopropanoic Acid; BOC- β-alanine; Boc-3-aminopropionic Acid;N-(t-Butoxycarbonyl)- β-alanine; N-(tert-Butoxycarbonyl)-3-aminopropionic Acid;N-(tert-Butyloxycarbonyl)- β-alanine; N-Boc- β-alanine; N-[(t-Butyloxy)carbonyl]- β-alanine; N-tert-Butoxycarbonyl-3-aminopropanoic Acid;N-tert-Butoxycarbonyl- β-alanine; N-[ (1, 1-Dimethylethoxy) carbonyl]- β -alanine; 3- (tert-Butoxycarbonylamino) propanoic Acid; 3- (tert-Butoxycarbonylamino) propionic Acid; 3-[N- (tert-Butoxycarbonyl) amino]propionic Acid. Grades: Highly Purified. CAS No. 3303-84-2. Pack Sizes: 50g, 100g, 250g, 500g. Molecular Formula: C8H15NO4, Molecular Weight: 189.21. US Biological Life Sciences. | Worldwide |
| BOP sodium | BOP sodium is a potent and selective dual α9β1/α4β1 integrin inhibitor with K d values in the picomolar range. BOP sodium shows the rapid and preferential mobilization of hematopoietic stem cell (HSC) and progenitors. BOP sodium has little inhibitory activity on α4β7, α1β1, α2β1, and α5β1, αIIBβ3 integrins [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1947348-42-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-129453. | |
| BOP sodium salt | BOP is a dual α9β1/α4β1 integrin inhibitor preferentially mobilizes HSCs and progenitors. Synonyms: N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine sodium salt. Grades: ≥98% by HPLC. CAS No. 1947348-42-6. Molecular formula: C25H28N3O7SNa. Mole weight: 537.56. | |
| BTT 3033 | BTT 3033 is a selective inhibitor of α2β1 integrin (EC50 = 130 nM for α2β1 binding to collagen I) that binds to the α2I domain. BTT 3033 inhibits platelet aggregation to collagen I coated capillaries under flow, and also inhibits binding of α2-expressing CHO cells to collagen I under shear stress conditions. Synonyms: BTT-3033; BTT 3033; BTT3033; 1- (4-Fluorophenyl)-N-methyl-N-[4[[ (phenylamino)carbonyl]amino]phenyl]-1H-pyrazole-4-sulfonamide. Grades: ≥98% by HPLC. CAS No. 1259028-99-3. Molecular formula: C23H20FN5O3S. Mole weight: 465.5. | |
| Carotegrast | Carotegrast is an anti-inflammatory agent as a Integrin alpha4 inhibitor. Uses: Integrin alpha4 inhibitors. Synonyms: (2S)-2-[(2,6-dichlorobenzoyl)amino]-3-[4-[6-(dimethylamino)-1-methyl-2,4-dioxoquinazolin-3-yl]phenyl]propanoic acid. Grades: ≥98%. CAS No. 401904-75-4. Molecular formula: C27H24Cl2N4O5. Mole weight: 555.41. | |
| Carotegrast | Carotegrast is an orally available α4 integrin receptor inhibitor with anti-inflammatories activities. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HCA2969. CAS No. 401904-75-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14857. | |
| Carotegrast methyl | Carotegrast methyl (AJM300) is an orally active and selective α4 integrin antagonist. HCA2969, an active metabolite of Carotegrast methyl, is a specific and dual α4β1/α4β7 integrin antagonist. Carotegrast methyl prevents the development of colitis in mice [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AJM300. CAS No. 401905-67-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124290. | |
| CEP-37440 | CEP-37440 is an orally available dual kinase inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and focal adhesion kinase (FAK), with potential antineoplastic activity. Upon administration, ALK-FAK inhibitor CEP-37440 selectively binds to and inhibits ALK kinase and FAK kinase. The inhibition leads to disruption of ALK- and FAK-mediated signal transduction pathways and eventually inhibits tumor cell growth in ALK- and FAK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; its dysregulation and gene rearrangements are associated with a variety of tumors. The cytoplasmic tyrosine kinase FAK, a signal transducer for integrins, is upregulated and constitutively activated in various tumor types; it plays a key role in tumor cell migration, proliferation, survival, and tumor angiogenesis. Synonyms: CEP-37440; CEP 37440; CEP37440. CAS No. 1391712-60-9. Molecular formula: C30H38ClN7O3. Mole weight: 580.12. | |
| Cilengitide | Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(V)beta(3) and alpha(V)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. It is being studied for the treatment of glioblastoma. Synonyms: 2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid. Grades: ≥98%. CAS No. 188968-51-6. Molecular formula: C27H40N8O7. Mole weight: 588.65. | |
| Cilengitide TFA salt | Cilengitide TFA salt, is a cyclic Arg-Gly-Asp acid pentapeptide that induces anoikis in angiogenic blood vessels and brain tumor, selectively and potently blocks the ligation of theαvβ3 andαvβ5 integrins to provisional matrix proteins such as vitronectin, fibronectin, fibrinogen, von Willebrand factor, osteopontin, and others. Synonyms: Cilengitide trifluoroacetate. Grades: >98%. CAS No. 199807-35-7. Molecular formula: C29H41F3N8O9. Mole weight: 702.68. | |
| Collagen Type I α1 chain (502-516) | Collagen Type I α1 chain (502-516) corresponds to the integrin alpha2beta1 binding site of collagen I. The GER motif is crucial for recognition. Synonyms: Collagen α1(l) (502-516); H-Gly-Phe-Hyp-Gly-Glu-Arg-Gly-Val-Glu-Gly-Pro-Hyp-Gly-Pro-Ala-NH2. Grades: ≥95%. Molecular formula: C63H95N19O21. Mole weight: 1454.54. | |
| c(phg-isoDGR-(NMe)k) | c(phg-isoDGR-(NMe)k) is a selective and potent α5β1-integrin ligand with IC50 of 2.9 nM. Grades: >98%. CAS No. 1844830-65-4. Molecular formula: C27H41N9O7. Mole weight: 603.67. | |
| c(RGDfK) | Cyclo (-RGDfK) is a potent and selective αvβ3 integrin inhibitor. Grades: 98%. CAS No. 161552-03-0. Molecular formula: C27H41N9O7. Mole weight: 603.67. | |
| Cucurbitacin B | Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids; could repress cancer cell progression.IC50 value:Target: anticancer natural compoundin vitro: Cucurbitacin-B inhibited growth and modulated expression of cell-cycle regulators in SHSY5Y cells. At the molecular level, we found that Cucurbitacin-B inhibited AKT signaling activation through up-regulation of PTEN. CuB induced apoptosis of A549 cells in a -concentration-dependent manner, as determined by fluorescence microscopy, flow cytometry and transmission electron microscopy. CuB dose-dependently inhibited lung cancer cell proliferation, with cell cycle inhibition and cyclin B1 downregulation. Apoptosis induced by CuB was shown to be associated with cytochrome c release, B-cell lymphoma 2 downregulation and signal transducer and activator of transcription 3 pathway inhibition. CuB inhibited ITGA6 and ITGB4 (integrin α6 and integrin β4), which are overexpressed in breast cancer. Furthermore, CuB also induced the expression of major ITGB1and ITGB3, which are known to cause integrin-mediated cell death. Cuc B treatment caused DNA double-strand breaks (DSBs) without affecting the signal transducer and activator of transcription 3 (STAT3), the potential molecular target for Cuc B. Cuc B triggers ATM-activated Chk1-Cdc25C-Cdk1, which could be reversed by both ATM siRNA and Chk1 siRNA. Cuc B also triggers ATM-activated p53-14-3-3-σ pa |  |
| CWHM-12 | CWHM 12 demonstrated high potency against all of the five possible β subunit binding partners (αvβ1, αvβ3, αvβ5, αvβ6 and αvβ8) in in vitro ligand-binding assays, with somewhat less potency against αvβ5 than against the other αv integrins. Treated mice with CCl4 for 3 weeks to establish fibrotic disease and then treated with CWHM 12 or vehicle for the final 3 weeks of CCl4. CWHM12 significantly reduced liver fibrosis even after fibrotic disease had been established. Similar to our findings in the liver, administration of CWHM 12 significantly inhibited progression of pulmonary fibrosis. Synonyms: CWHM12; CWHM 12; CWHM-12. Grades: >98%. CAS No. 1564286-55-0. Molecular formula: C26H32BrN5O6. Mole weight: 590.47. | |
| Cyclo(-Arg-Ala-Asp-D-Phe-Cys) | Cyclo(-Arg-Ala-Asp-D-Phe-Cys) is a control peptide for the αvβ3 integrin binding cyclic RGD peptide c(RGDfC). Synonyms: c(RADfC); Cyclo(L-alanyl-L-α-aspartyl-D-phenylalanyl-L-cysteinyl-L-arginyl). Grades: ≥95%. CAS No. 1055991-02-0. Molecular formula: C25H36N8O7S. Mole weight: 592.68. | |
| Cyclo(-Arg-Gly-Asp-D-Phe-Glu) | Cyclo(-Arg-Gly-Asp-D-Phe-Glu), a cyclic RGD peptide, has been used as an integrin ligand for radiologic labeling, on gold nanoparticles and for the delivery of nanomedicine. Its negative control c(RADfE) is also available. Synonyms: cyclo[L-arginyl-glycyl-L-alpha-aspartyl-D-phenylalanyl-L-alpha-glutamyl]; c(RGDfE); Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-α-glutamyl). Grades: ≥95%. CAS No. 756500-22-8. Molecular formula: C26H36N8O9. Mole weight: 604.62. | |
| Cyclo(Arg-Gly-Asp-D-Phe-Val) | Cyclo(Arg-Gly-Asp-D-Phe-Val) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 137813-35-5. Molecular formula: C26H38N8O7. Mole weight: 574.63. Purity: 0.95. Product ID: ACM137813355-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA | Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) (Cyclo(RGDfV) (TFA))is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) can be used for the research of acute myeloid leukemia [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Cyclo(RGDfV) TFA; C(RGDfV) TFA. CAS No. 199807-33-5. Pack Sizes: 5 mg. Product ID: HY-P1613A. | |
| Cyclo(RADfK) | Cyclo(RADfK) is a selective α(V)β(3) integrin ligand. It has been used for research, therapy, and diagnosis of neoangiogenesis. It is also used as a negative control for the cyclo (-RGDfK-), the RGD peptide, which are modulators of cell adhesion and are recognized by several members of the integrin family. It has low affinity binding to integrin peptides. Uses: Cyclo(radfk) has been used for research, therapy, and diagnosis of neoangiogenesis. it is also used as a negative control for the cyclo (-rgdfk-), the rgd peptide. Synonyms: c(RADfK); cyclo[L-alanyl-L-alpha-aspartyl-D-phenylalanyl-L-lysyl-L-arginyl]. Grades: ≥95%. CAS No. 756500-23-9. Molecular formula: C28H43N9O7. Mole weight: 617.70. | |
| Cyclo(RGDfC) acetate | Cyclo(RGDfC) acetate is a potent and selective inhibitor of the αvβ3 integrin receptor. Synonyms: Cyclo(-RGDfC) acetate; cyclo[Arg-Gly-Asp-D-Phe-Cys] acetate; cyclo[L-arginyl-glycyl-L-alpha-aspartyl-D-phenylalanyl-L-cysteinyl] acetic acid; Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-cysteinyl) acetate. Grades: ≥95%. CAS No. 2171504-31-5. Molecular formula: C26H38N8O9S. Mole weight: 638.69. | |
| cyclo(RGDyC) acetate | Cyclo(RGDyC) acetate, a cyclic RGDyc sequence, is an integrin avb3-affine polypeptide. Synonyms: Cyclo(-RGDyC) acetate; cyclo[L-arginyl-glycyl-L-alpha-aspartyl-D-tyrosyl-L-cysteinyl] acetate; Cyclo(L-arginylglycyl-L-α-aspartyl-D-tyrosyl-L-cysteinyl) acetate. Grades: ≥95%. Molecular formula: C26H38N8O10S. Mole weight: 654.70. | |
| Cyclo(RGDyK) Trifluoroacetate | Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM. Synonyms: Cyclo (RGDyK); Cyclo RGDyK; Cyclo(RGDyK) trifluoroacetate. Grades: >98%. CAS No. 250612-42-1. Molecular formula: C31H43F6N9O12. Mole weight: 847.71. | |
| Defactinib | Defactinib, also known as VS-6063 and PF-04554878, is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation and survival. The tyrosine kinase FAK is , a signal transducer for integrins that is upregulated in many tumor cell types and is involved in tumor cell invasion, migration and proliferation. Synonyms: N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide; VS6063; VS 6063; VS-6063; PF04554878; PF-04554878; PF 04554878; PF4554878; PF-4554878. Grades: >98%. CAS No. 1073154-85-4. Molecular formula: C20H21F3N8O3S. Mole weight: 510.496. | |
| DGEA | DGEA interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors. Synonyms: H-Asp-Gly-Glu-Ala-OH; a2b1 Integrin Recognition Sequence; α2β1 Integrin Ligand Peptide; L-Alanine, L-α-aspartylglycyl-L-α-glutamyl-; L-Alanine, N-[N-(N-L-α-aspartylglycyl)-L-α-glutamyl]-; L-α-Aspartylglycyl-L-α-glutamyl-L-alanine; Peptide (mouse protein CHL1 integrin interaction motif). Grades: 95%. CAS No. 134580-64-6. Molecular formula: C14H22N4O9. Mole weight: 390.35. | |
| E7820 | E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC 50 of 0.11 μg/ml. E7820 modulates α-1, α-2, α-3, and α-5 integrin mRNA expression. Antiangiogenic and antitumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ER68203-00. CAS No. 289483-69-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14571. | |
| E 7820 | E7820 is an orally active unique angiogenesis inhibitor that inhibits the expression of integrin α2 subunit on endothelial cells and has antiangiogenic and antitumor activities. E7820 regulates the expression of α-1, α-2, α-3 and α-5 integrin mRNA, and inhibits rat aortic angiogenesis with an IC50 of 0.11 μg/mL. Synonyms: ER68203-00; N-(3-Cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzene-sulfonamide; NSC-719239; 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide; Benzenesulfonamide, 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)-. Grades: ≥95%. CAS No. 289483-69-8. Molecular formula: C17H12N4O2S. Mole weight: 336.37. | |
| Echistatin, α1 isoform | Echistatin, α1 isoform is a potent and irreversible αVβ3 integrin antagonist (Ki = 0.27 nM). It exhibits inhibitory activity for bone reabsorption (IC50 = 0.1 nM) and prevents ADP-induced platelet aggregation by inhibiting glycoprotein IIb/IIIa (GpIIb/IIIa, αIIbβ3) receptors (IC50 = 30 nM) in vitro. Synonyms: H-Glu-Cys(1)-Glu-Ser-Gly-Pro-Cys(2)-Cys(3)-Arg-Asn-Cys(1)-Lys-Phe-Leu-Lys-Glu-Gly-Thr-Ile-Cys(4)-Lys-Arg-Ala-Arg-Gly-Asp-Asp-Met-Asp-Asp-Tyr-Cys(2)-Asn-Gly-Lys-Thr-Cys(3)-Asp-Cys(4)-Pro-Arg-Asn-Pro-His-Lys-Gly-Pro-Ala-Thr-OH; L-alpha-glutamyl-L-cysteinyl-L-alpha-glutamyl-L-seryl-glycyl-L-prolyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-asparagyl-L-cysteinyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-alpha-glutamyl-glycyl-L-threonyl-L-isoleucyl-L-cysteinyl-L-lysyl-L-arginyl-L-alanyl-L-arginyl-glycyl-L-alpha-aspartyl-L-alpha-aspartyl-L-methionyl-L-alpha-aspartyl-L-alpha-aspartyl-L-tyrosyl-L-cysteinyl-L-asparagyl-glycyl-L-lysyl-L-threonyl-L-cysteinyl-L-alpha-aspartyl-L-cysteinyl-L-prolyl-L-arginyl-L-asparagyl-L-prolyl-L-histidyl-L-lysyl-glycyl-L-prolyl-L-alanyl-L-threonine (2->11),(7->32),(8->37),(20->39)-tetrakis(disulfide). Grades: >98%. CAS No. 154303-05-6. Molecular formula: C217H341N71O74S9. Mole weight: 5417.05. | |
| EILEVPST | EILEVPST is a recombinant human fibronectinderived low-molecular-weight peptide fragment. EILEVPST can promote cell type-specific α4 integrin-mediated adhesion. EILEVPST can be used for the research of thrombogenesis [1]. Uses: Scientific research. Group: Peptides. CAS No. 239075-62-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P3533. | |
| Etaracizumab | Etaracizumab (LM 609) is an α v β 3 integrin IgG1 monoclonal antibody. Etaracizumab inhibits angiogenesis and melanoma tumor growth. Etaracizumab can be used to research anticancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: LM 609; MEDI 523; Anti-αvβ3 Integrin Recombinant Antibody. CAS No. 892553-42-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99291. | |
| Etrolizumab | Etrolizumab is an anti-β7 integrin monoclonal antibody. Etrolizumab has been investigated as a medication used in patients with moderately to severely active ulcerative colitis who had been previously treated with anti-tumour necrosis factor (TNF) agents. Synonyms: rhuMAb Beta7; RG7413; PRO145223. CAS No. 1044758-60-2. | |
| Etrolizumab | Etrolizumab (rhuMAb Beta7) is a gut-selective, anti- β7 integrin monoclonal antibody. Etrolizumab is specific targeting of the β7 subunit of α4β7 and αEβ7 integrins with K i values of 18 nM and 1800 pM for Human α4β7 and Human αEβ7-293, respectively. Etrolizumab can be used in research of inflammatory bowel disease (IBD) [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: rhuMAb Beta7; RG7413; PRO145223. CAS No. 1044758-60-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9984. | |
| Fibronectin | Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans [1]. Uses: Scientific research. Group: Natural products. CAS No. 86088-83-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3160. | |
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