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| Product | Description | |
|---|---|---|
| Interferon-?A human | ?95%, suitable for cell culture, buffered aqueous solution, recombinant, expressed in E. coli. Group: Fluorescence/luminescence spectroscopy. |  |
| Interferon-a-IFNa-R Interaction Inhibitor (N-Methyl-1- (2- (naphthalen-1-ylthio) phenyl) methanamine, HCl, N-Methyl-N- (2- (1-naphthylthio) benzyl) amine, HCl, IFN-alpha Inhibitor) | A nonpeptidic thiophenylmethanamine compound that binds interferon-a (Kd= 4uM for human IFN-a) and prevents IFN-a and IFNAR interaction-dependent IFN-a production in murine BM-pDCs (bone marrow-derived plasmacytoid dendritic cells) cultures upon MVA infection (IC50<4.5uM), while exhibiting no inhibitory effect against IL-12 production in the same cultures when applied at non-toxic concentrations (<4.5uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| Interferon-? from mouse | ?98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Interferon-? from rat | ?97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Interferon-? human | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Interferon-? human | recombinant, expressed in E. coli, ?98% (SDS-PAGE), lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Interferon-?-Inducible Protein-10 human | ?97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Interferon-Inducible T Cell ? Chemoattractant human | ?97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Interferon ? antibody produced in goat | affinity isolated antibody, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Interferon-? antibody produced in goat | IgG fraction of antiserum. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Interferon-? Inducible Protein antibody produced in goat | IgG fraction of antiserum, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Interferon-?/? Receptor 1 antibody produced in goat | affinity isolated antibody, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Interferon-? Receptor 1 (IFN-? R1) antibody produced in goat | affinity isolated antibody, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-phospho-Interferon-? Receptor ? (pTyr457) antibody produced in rabbit | affinity isolated antibody. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-Interferon-? antibody produced in mouse | clone 25718, purified immunoglobulin, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-Interferon-? antibody produced in rat | clone 37895, purified immunoglobulin, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Ropeginterferon alfa-2b | Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft) is a monopegylated IFN-α that can be used for the research of myeloproliferative neoplasms [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Ropeginterferon alfa-2b-njft; PEG-proline-interferon alpha-2b. CAS No. 1335098-50-4. Pack Sizes: 250 μg. Product ID: HY-P99348. |  |
| 10-Hydroxydecanoic acid | 10-Hydroxydecanoic acid (10-HDAA) is a saturated fatty acid derived from 10-hydroxy-trans-2-decenoic acid, which can be isolated from royal jelly. 10-Hydroxydecanoic acid exhibits various biological activities, including anti-inflammatory, insecticidal, anti-malarial, and anti-Leishmania properties, as well as enhancing antigen-specific immune responses. The anti-inflammatory effects of 10-Hydroxydecanoic acid are primarily mediated by inhibiting the activation of NF-κB and the translation of interferon regulatory factor 1 ( IRF-1 ), which reduces the production of interleukin 6 ( IL-6 ) and nitric oxide ( NO ) in inflammatory cells. Additionally, 10-Hydroxydecanoic acid alleviates neuroinflammatory responses through the p53-autophagy pathway and the p53-NLRP3 pathway. Finally, 10-Hydroxydecanoic acid enhances antigen-specific immune responses by promoting the effective uptake of antigens by microfold cells [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: NSC 15139; 10-HDAA. CAS No. 1679-53-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-Y0148. | |
| 2',2'-cGAMP | 2',2'-cGAMP is a powerful cyclic dinucleotide, widely recognized in the field of compound due to its remarkable capabilities as an immunomodulatory agent. Through its innate ability to act as an authentic agonist of the stimulator of interferon genes (STING), it efficiently triggers the activation of downstream signaling pathways, thereby augmenting the immune system's ability to study both infectious pathogens and malignant tumors. Grade: > 95%. Molecular formula: C20H30N12O13P2. Mole weight: 708.49. |  |
| 2'2'-cGAMP | c[A(2',5')pG(2',5')p] is a cyclic dinucleotide analogue of c[G(2',5')pA(3',5')p], the metazoan second messenger and STING activator. It can bind the signalling protein STING and induces type I interferons. Synonyms: cGAMP(2'-5'); 2'-Guanylic acid, adenylyl-(2'→5')-, cyclic nucleotide; c[G(2',5')pA(2',5')p]; 2',5'-cyclic GMP-AMP; Cyclic (adenosine-(2'→5')-monophosphate-guanosine-(2'→5')-monophosphate). Grade: ≥98% by HPLC. CAS No. 1465774-27-9. Molecular formula: C20H24N10O13P2. Mole weight: 674.41. | |
| 23-c-di-AM(PS)2 (Rp,Rp) | 23-c-di-AM(PS)2 (Rp,Rp) (ADU-S100), an activator of stimulator of interferon genes ( STING ), leads to potent and systemic tumor regression and immunity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ADU-S100; MIW815; ML RR-S2 CDA. CAS No. 1638241-89-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-12885. | |
| 23-c-di-AM(PS)2 (Rp,Rp) ammonium salt | 23-c-di-AM(PS)2 (Rp,Rp) ammonium salt (ADU-S100 ammonium salt), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ADU-S100 ammonium salt; MIW815 ammonium salt; ML RR-S2 CDA ammonium salt. CAS No. 1638750-96-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12885B. | |
| 23-c-di-AM(PS)2 (Rp,Rp) disodium salt | 23-c-di-AM(PS)2 (Rp,Rp) disodium salt (ADU-S100 disodium salt) is an activator of stimulator of interferon genes (STING). Uses: Scientific research. Group: Signaling pathways. Alternative Names: ADU-S100 disodium salt; MIW815 disodium salt; ML RR-S2 CDA disodium salt. CAS No. 1638750-95-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12885A. | |
| 23-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt | 23-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt (ADU-S100 enantiomer ammonium salt) is the less active enantiomer of 23-c-di-AM(PS)2 (Rp,Rp). 23-c-di-AM(PS)2 (Rp,Rp) is an activator of stimulator of interferon genes (STING)[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ADU-S100 enantiomer ammonium salt; MIW815 enantiomer ammonium salt; ML RR-S2 CDA enantiomer ammonium salt. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12885C. | |
| 2',3'-cGAMP | 2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 2'-3'-cyclic GMP-AMP. CAS No. 1441190-66-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100564. | |
| 2',3'-cGAMP | 2',3'-cGAMP was considered to be the metazoan second messenger which is produced by cGAMP synthase (cGAS), the mammalian intrinsic immune DNA sensor. It can activate innate immunity by directly binding the endoplasmic reticulum-resident receptor STING (stimulator of interferon genes). Synonyms: Cyclic [G(2',5')pA(3',5')p]; 2'-Guanylic acid, adenylyl-(3'→5')-, cyclic nucleotide; 2',3'-Cyclic guanosine adenosine monophosphate; 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate; 2'-3'-cyclic GMP-AMP; cGAMP(2'→5'); c[G(2',5')pA(3',5')p]; Cyclic Gp(2'→5')Ap(3'→5'). Grade: ≥95%. CAS No. 1441190-66-4. Molecular formula: C20H24N10O13P2. Mole weight: 674.41. | |
| 2',3'-cGAMP sodium | 2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 2'-3'-cyclic GMP-AMP sodium. CAS No. 2734858-36-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-100564A. | |
| 2',3'-cGAMP sodium salt | 2',3'-cGAMP sodium is an endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β. 2',3'-cGAMP is an effective adjuvant that boosts the production of antigen-specific antibodies and T cell responses in mice. Synonyms: Cyclic [G(2',5')pA(3',5')p] sodium; cyclic GMP-AMP sodium; 2',3'-cyclic GMP-AMP sodium; 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt. Grade: 95%. CAS No. 2734858-36-5. Molecular formula: C20H22N10Na2O13P2. Mole weight: 718.38. | |
| 3',3'-cGAMP | c-(ApGp) is an analogue of c-diAMP and c-diGMP, the bacterial second messengers, which plays a role in Vibrio choleraepathogenesis and activates the production of interferon via STING. Synonyms: 3'-Guanylic acid, adenylyl-(3'→5')-, cyclic nucleotide; 2',3'-CGAMP; 3',3'-Cyclic guanosine adenosine monophosphate; cGAMP; Cyclic [G(3',5')pA(3',5')p]; Cyclic AMP-GMP; Cyclic GMP-AMP; Cyclic (adenosine monophosphate-guanosine monophosphate); c-GpAp; 3',3'-cGAMP. Grade: ≥98%. CAS No. 849214-04-6. Molecular formula: C20H24N10O13P2. Mole weight: 674.41. | |
| AC 264613 | AC 264613 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 7.5). AC 264613 inhibits interferon regulatory factor 5 and decreases interleukin-12p40 production via lipopolysaccharide-stimulated macrophages. PI hydrolysis, Ca2+ mobilization and cellular proliferation are activated by AC 264613 in vitro (pEC50 = 6.9, 7.0 and 7.5, respectively). Synonyms: AC-264613; AC 264613; AC264613; (±)-(3R,4S)-2-Oxo-4-phenyl-3-pyrollidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide. Grade: ≥98% by HPLC. CAS No. 1051487-82-1. Molecular formula: C19H18BrN3O2. Mole weight: 400.27. | |
| ADU-S100 ammonium salt | ML RR-S2 CDA ammonium salt is an inducer of stimulator of interferon genes (STING). It can increases type I interferon production by THP-1 human monocytes relative to unmodified cyclic di-AMP, indicating the ML enhances its action at human STING. Synonyms: MIW815 ammonium salt; ML RR-S2 CDA ammonium salt; [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-adenosine, cyclic nucleotide, diammonium salt; STING Inducer-1. Grade: 98%. CAS No. 1638750-96-5. Molecular formula: C20H30N12O10P2S2. Mole weight: 724.6. | |
| ADU-S100 disodium salt | ADU-S100 disodium salt (MIW815 disodium salt) is an activator of stimulator of interferon genes (STING) for treating cancer. Synonyms: MIW815 disodium salt; ML RR-S2 CDA disodium salt; 2',3'-c-di-AM(PS)2 (Rp,Rp); Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide, sodium salt (1:2); ADU-S 100; MIW 815. Grade: 98%. CAS No. 1638750-95-4. Molecular formula: C20H22N10Na2O10P2S2. Mole weight: 734.51. | |
| Aloe emodin | Aloe-emodin is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71. Aloe-emodin has anti-tumor activity, antibacterial activity, immunosuppressive effect, and purgative effect. It is now widely used as a raw material for medicines and cosmetics. Uses: Antineuroectodermal tumor. Synonyms: Aloe-emodin; Aloe emodin; 481-72-1; Aloeemodin; Aloe-emodine; Rhabarberone; 1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione; 3-Hydroxymethylchrysazine; 3-Hydroxymethylchrysazin; EMODINE; 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone; 1,8-Dihydroxy-3-hydroxymethylanthraquinone; 9,10-Anthracenedione, 1,8-dihydroxy-3-(hydroxymethyl)-; 1,8-Dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione; NSC 3862. Grade: >98%. CAS No. 481-72-1. Molecular formula: C15H10O5. Mole weight: 270.24. | |
| Anifrolumab | Anifrolumab is a monoclonal antibody that blocks the activity of type I interferon (IFN). Anifrolumab has been investigated for the treatment of systemic lupus erythematosus (SLE). Synonyms: Saphnelo. CAS No. 1326232-46-5. | |
| Anifrolumab | Anifrolumab is a type I interferon ( IFN ) receptor antagonist, a human monoclonal antibody. Anifrolumab blocks the activity of type I interferon. Anifrolumab can be used in systemic lupus erythematosus (SLE) research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1326232-46-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99168. | |
| AP4A | AP4A is a signal molecule for DNA replication in mammalian cells. AP4A is used as a primer for oligoadenylate synthesis catalyzed by interferon-inducible 2-5A synthetase. AP4A is an inhibitor of eosinophil-derived neurotoxin (EDN). Uses: Ap4a is an inhibitor of eosinophil-derived neurotoxin (edn). Synonyms: (AppppA); P1-(5'-Adenosyl) P4-(5'-adenosyl) tetraphosphate, Sodium salt. Grade: ≥ 95% by HPLC. CAS No. 5542-28-9. Molecular formula: C20H28N10O19P4 (free acid). Mole weight: 836.39 (free acid). | |
| Ascomycin | Ascomycin inhibits the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in target cells.Ascomycin (also known as Immunomycin, FR 900520, and FK-520) is an analog of tacrolimus (FK-506) with immunosuppressive, neurotrophic and antifungal activities. Ascomycin can be used to prevent rejection after an organ transplant, and to treat autoimmune diseases and skin diseases.Ascomycin inhibits the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in target cells. Paul, C., et al. "Ascomycins: promising agents for the treatment of inflammatory skin diseases." Expert Opin. Investig. Drugs. 9: 69-77 (2000). Moll...the compounds." J. Infect. Dis. 191: 1342-1349 (2005).FK-520 might be a substrate for P-glycoprotein; expression of P-glycoprotein in yeast cells resulted in resistance to growth inhibition by FK-520. Raymond, M., et al. "Functional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520." Mol. Cell Biol. 14: 277-286 (1994). Group: Biochemicals. Alternative Names: Immunomycin; FK-520; FR-520; NSC-106410; FR 900520; L 683590; Changchuanmycin. Grades: Highly Purified. CAS No. 104987-12-4. Pack Sizes: 25mg, 50mg, 100mg, 250mg. Molecular Formula: C43H69NO12, Molecular Weight: 792.01. US Biological Life Sciences. | Worldwide |
| Ascomycin (High Purity) (Immunomycin, FK520, Analog of FK-506, FR-900520, L-683590, NSC 106410, WS 7238A) | Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin (protein phosphatase 2B (PP2B)). Suppresses the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant (antiepileptic). Group: Biochemicals. Grades: Highly Purified. CAS No. 104987-12-4. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Avridine | A potent synthetic non-immunogenic adjuvant that can induce arthritis in most rat strains; immunomodulator and interferon-inducing. Group: Biochemicals. Alternative Names: 2, 2'- [ [3- (Dioctadecylamino) propyl] imino] bisethanol; CP 20961; CP-20961; N,N-Dioctadecyl-N',N'-bis(2-hydroxyethyl)-1,3-diaminopropane; N, N-Dioctadecyl-N', N'-bis (2-hydroxyethyl) propanediamine. Grades: Highly Purified. CAS No. 35607-20-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Avridine | Avridine is a potent synthetic non-immunogenic adjuvant that used to induce arthritis in Lewis (LEW) and DA rats. Uses: A potent synthetic non-immunogenic adjuvant that can induce arthritis in most rat strains; immunomodulator and interferon-inducing. Synonyms: CP 20961; CP20961; CP-20961; N,N-Dioctadecyl-N',N'-bis(2-hydroxyethyl)-1,3-diaminopropane. Grade: ≥98%. CAS No. 35607-20-6. Molecular formula: C43H90N2O2. Mole weight: 667.19. | |
| bevacizumab-awwb | Bevacizumab-awwb is the first anti-cancer biosimilar and the first bevacizumab biosimilar approved for the treatment of five types of cancer, including in combination with chemotherapy for non-squamous non-small cell lung cancer (NSCLC), in combination with chemotherapy for metastatic colorectal cancer (mCRC), in combination with interferon alfa for glioblastoma, metastatic renal cell carcinoma and in combination with chemotherapy for persistent, recurrent, or metastatic carcinoma of the cervix. Uses: The traetment of nsclc, etc. Synonyms: Mvasi. | |
| BIT225 | BIT-225 is a NCp7 zinc finger inhibitor potentially for the treatment of HCV infection and HIV infection. BIT225 inhibits HIV-1 replication in myeloid dendritic cells. BIT225, inhibits bovine viral diarrhea virus in vitro and shows synergism with recombinant interferon-alpha-2b and nucleoside analogues. BIT225 against HIV-1 release from human macrophages. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BIT-225; BIT 225; BIT225. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 917909-71-8. Molecular formula: C16H15N5O. Mole weight: 293.33. Purity: >98%. IUPACName: N-carbamimidoyl-5-(1-methyl-1H-pyrazol-4-yl)-2-naphthamide. Canonical SMILES: O=C(C1=CC=C2C(C3=CN(C)N=C3)=CC=CC2=C1)NC(N)=N. Product ID: ACM917909718. Alfa Chemistry ISO 9001:2015 Certified. |  |
| C-176 | C-176 is a highly potent and selective small-molecule antagonist of the stimulator of interferon genes (STING) protein. It is also a central signaling component of the intracellular DNA sensing pathway. Synonyms: STING inhibitor C 176; C176; C 176. Grade: ≥98%. CAS No. 314054-00-7. Molecular formula: C11H7IN2O4. Mole weight: 358.09. | |
| C-178 | C-178 is a highly potent and selective small-molecule antagonist of the stimulator of interferon genes (STING) protein. It binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. C-178 also blocks palmitoylation (PMA)-induced clustering of STING. It inhibits the CMA-induced phosphorylation of TBK1, which is downstream protein kinase of STING. C-178 prevents the increases in Ifnb1 expression in bone marrow-derived macrophages (BMDMs). Synonyms: C178; C 178. Grade: ≥98%. CAS No. 329198-87-0. Molecular formula: C17H10N2O5. Mole weight: 322.27. | |
| c-(Ap-8-AET-Gp) | c-(Ap-8-AET-Gp) is an analogue of messenger c-(ApGp), the bacterial second, which is used as a ligand for affinity chromatography or for coupling of labelling structures such as fluorophores. c-(ApGp) plays a role in Vibrio choleraepathogenesis and activates the production of interferon via STING. Synonyms: Cyclic (adenosine monophosphate- 8- (2- aminoethylthio)guanosine monophosphate), sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C22H29N11O13P2S (free acid). Mole weight: 749.6 (free acid). | |
| c-(Ap-8-Br-Gp) | c-(Ap-8-Br-Gp) is an analogue of c-(ApGp), the potential bacterial second messenger, which is used for binding studies and as precursor for further modifications with spacers or labels. c-(ApGp) plays a role in Vibrio choleraepathogenesis and activates the production of interferon via STING. Synonyms: Cyclic (adenosine monophosphate- 8- bromoguanosine monophosphate), sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C20H23BrN10O13P2 (free acid). Mole weight: 753.3 (free acid). | |
| c-(Ap-8-Fluo-AET-Gp) | c-(Ap-8-Fluo-AET-Gp) is a fluorescent analogue of c-(ApGp), which can participate in Vibrio choleraepathogenesis and stimulate the production of interferon. Synonyms: Cyclic(adenosine monophosphate-8-(2-[fluoresceinyl]aminoethylthio)guanosine monophosphate), sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C43H39N11O19P2S (free acid). Mole weight: 1107.9 (free acid). | |
| c-(ApIp) | c-(ApIp) is a STING (stimulator of interferon genes)-activating synthetic cyclic dinucleotide (CDN). Synonyms: 3'-Inosinic acid, adenylyl-(3'→5')-, cyclic nucleotide; Cyclic (adenosine monophosphate-inosine monophosphate); cAIMP; CL592; 9-((2R,3R,3aS,7aR,9R,10R,10aS,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecin-2-yl)-1,9-dihydro-6H-purin-6-one; 1-(6-Amino-9H-purine-9-yl)-1'-(6-hydroxy-9H-purine-9-yl)[3-O,5'-O-(hydroxyphosphinylidene)-5-O,3'-O-(hydroxyphosphinylidene)bis(1-deoxy-beta-D-ribofuranose)]; 3',3'-cAIMP; 3',3'-c(ApIp). Grade: ≥ 95% by HPLC. CAS No. 1507367-51-2. Molecular formula: C20H23N9O13P2. Mole weight: 659.40. | |
| c-(ApIp) disodium salt | c-(ApIp) is a STING (stimulator of interferon genes)-activating synthetic cyclic dinucleotide (CDN). Synonyms: 3'3'-cAIMP sodium salt, 3'3'-c(ApIp) sodium salt; 3'-Inosinic acid, adenylyl-(3'→5')-, cyclic nucleotide, sodium salt; Cyclic (adenosine monophosphate-inosine monophosphate) sodium salt; cAIMP sodium salt; CL592 sodium salt; 1-(6-Amino-9H-purine-9-yl)-1'-(6-hydroxy-9H-purine-9-yl)[3-O,5'-O-(hydroxyphosphinylidene)-5-O,3'-O-(hydroxyphosphinylidene)bis(1-deoxy-beta-D-ribofuranose)] sodium salt. Molecular formula: C20H21N9Na2O13P2. Mole weight: 703.37. | |
| caspase-1 | From mammalian monocytes. This enzyme is part of the family of inflammatory caspases, which also includes caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. Cleaves pro-interleukin-1β (pro-IL-1β) to form mature IL-1β, a potent mediator of inflammation. Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-γ-inducing factor. Inhibited by Ac-Tyr-Val-Ala-Asp-CHO. Caspase-11 plays a critical role in the activation of caspase-1 in mi...proteinase; ICE. Enzyme Commission Number: EC 3.4.22.36. CAS No. 122191-40-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4211; caspase-1; EC 3.4.22.36; 122191-40-6; interleukin 1β-converting enzyme; protease VII; protease A; interleukin 1β precursor proteinase; interleukin 1 converting enzyme; interleukin 1β-converting endopeptidase; interleukin-1β convertase; interleukin-1β converting enzyme; interleukin-1β precursor proteinase; prointerleukin 1β protease; precursor interleukin-1β converting enzyme; pro-interleukin 1β proteinase; ICE. Cat No: EXWM-4211. |  |
| c-di-AMP | c-di-AMP is an agonist of stimulator of interferon genes (STING) for treating cancer. It is a second messenger in bacteria and archaea that is involved in the maintenance of osmotic pressure, response to DNA damage, and control of central metabolism, biofilm formation, acid stress resistance, and other functions. Synonyms: Cyclic diadenylate monophosphate; Cyclic diadenylate; Adenylic acid, cyclic ester; 3',5'-Cyclic diadenylic acid; Cyclic di-3',5'-adenylate; Cyclic di-AMP; Cyclic-di-AMP; Cyclic diadenosine monophosphate; (2R,3R,3aS,7aR,9R,10R,10aS,14aR)-2,9-bis(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxyoctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecine 5,12-dioxide. Grade: ≥95%. CAS No. 54447-84-6. Molecular formula: C20H24N10O12P2. Mole weight: 658.41. | |
| cGAMP | cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cyclic GMP-AMP; 3',3'-cGAMP. CAS No. 849214-04-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-12512. | |
| cGAMP disodium | cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4]. Uses: Scientific research. Group: Natural products. Alternative Names: Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium. CAS No. 2407516-83-8. Pack Sizes: 500 ?g; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-110385. | |
| cGAMP disodium | cGAMP diammonium activates stimulator of interferon genes (STING). cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. Synonyms: 3',3'-cGAMP disodium salt; 3'-Guanylic acid, adenylyl-(3'→5')-, cyclic nucleotide, disodium salt; 2',3'-CGAMP disodium salt; 3',3'-Cyclic guanosine adenosine monophosphate disodium salt; Cyclic [G(3',5')pA(3',5')p] disodium salt; Cyclic AMP-GMP disodium salt; Cyclic GMP-AMP disodium salt; Cyclic (adenosine monophosphate-guanosine monophosphate) disodium salt. Grade: 98%. CAS No. 2407516-83-8. Molecular formula: C20H22N10Na2O13P2. Mole weight: 718.37. | |
| CL 614 | CL 614, a derivative of cAIMP, is a novel STING (stimulator of interferon genes)-activating synthetic CDN. Synonyms: cAIMP Difluor; CL614; CL-614; 3'-Adenylic acid, 2'-deoxy-2'-fluoroinosinylyl-(3'→5')-2'-deoxy-2'-fluoro-, cyclic nucleotide; c-(2'FdAMP-2'FdIMP) sodium salt; 9-((2R,3R,3aR,7aR,9R,10R,10aR,14aR)-9-(6-amino-9H-purin-9-yl)-3,10-difluoro-5,12-dihydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecin-2-yl)-1,9-dihydro-6H-purin-6-one. CAS No. 1951464-78-0. Molecular formula: C20H21F2N9O11P2. Mole weight: 663.38. | |
| CL656 | CL656 is an agonist of stimulator of interferon genes (STING) for treating cancer. Synonyms: c-[2'FdAMP(S)-2'FdIMP(S)]; cAIM(PS)2 Difluor (Rp/Sp); Adenosine, 2'-deoxy-2'-fluoro-5'-O-(hydroxymercaptophosphinyl)-P-thioinosinylyl-(3'→5')-2'-deoxy-2'-fluoro-, cyclic nucleotide; CL 656; CL-656; (Rp/Sp) c-[2'FdAM(PS)-2'FdIM(PS]); 9-((2R,3R,3aR,7aR,9R,10R,10aR,14aR)-9-(6-amino-9H-purin-9-yl)-3,10-difluoro-12-hydroxy-5-mercapto-5-oxido-12-sulfidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecin-2-yl)-1,9-dihydro-6H-purin-6-one. Grade: >98%. CAS No. 1951464-79-1. Molecular formula: C20H21F2N9O9P2S2. Mole weight: 695.51. | |
| CM-272 | CM-272 is a first-in-class reversible and substrate-competitive dual inhibitor of G9a (GLP) and DNMTs. CM-272 inhibits cell proliferation and promotes apoptosis, inducing interferon-stimulated genes and immunogenic cell death in models of haematological neoplasia. Synonyms: CM 272; CM272. CAS No. 1846570-31-7. Molecular formula: C28H38N4O3. Mole weight: 478.63. | |
| CP-28888 | CP-28888, an interferon inducer, is more effective in mice, but less active in humans and lacks anti-rhinovirus effects. Synonyms: CP 28888-27; N,N-Dihexadecyl-1,3-benzenedi(methanamine); 1,3-Benzenedimethanamine, N1,N3-dihexadecyl-; N,N'-[1,3-Phenylenebis(methylene)]di(hexadecan-1-amine); N,N'-[1,3-Phenylenebis(methylene)]di(1-hexadecanamine). Grade: ≥95%. CAS No. 69938-75-6. Molecular formula: C40H76N2. Mole weight: 585.04. | |
| Cyclic GMP | Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. cGMP may also activate PDE to degrade cAMP, inhibit myocardial calcium current I Ca , and regulate myocardial contractility. The derivative of cyclic GMP (cGMP), 8-Br-cGMP, has antiplatelet activity, and cyclic GMP can be used in the study of antiviral immunity and cardiovascular diseases [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 7665-99-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-113469. | |
| cyclic GMP-AMP synthase | Cyclic Gp(2'-5')Ap(3'-5') is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines. Group: Enzymes. Synonyms: cGAMP synthase; cGAS. Enzyme Commission Number: EC 2.7.7.86. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3299; cyclic GMP-AMP synthase; EC 2.7.7.86; cGAMP synthase; cGAS. Cat No: EXWM-3299. | |
| Cyclic GMP sodium | Cyclic GMP (cGAMP) sodium is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP sodium can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP sodium may also activate PDE to degrade cAMP, inhibit myocardial calcium current I Ca , and regulate myocardial contractility. The derivative of Cyclic GMP sodium, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP sodium can be used in the study of antiviral immunity and cardiovascular diseases [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 40732-48-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-113469A. | |
| Dazostinag disodium | Dazostinag disodium (TAK-676) is an agonist of STING, triggering the activation of STING signaling pathway and type I interferons. Dazostinag disodium is also a modulator of immune system, resulting complete regressions and durable memory T-cell immunity. Dazostinag disodium promotes durable IFN-dependent antitumor immunity[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAK-676. CAS No. 2553413-93-5. Pack Sizes: 100 ?g; 500 ?g; 1 mg; 5 mg; 10 mg. Product ID: HY-148029. | |
| Dazukibart | Dazukibart is a mouse-derived, humanized IgG1κ antibody targeting interferon beta 1 ( IFNB1 ) [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2639474-65-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990036. | |
| Deleobuvir | Deleobuvir, also known as BI207127, a non-nucleoside hepatitis C virus NS5B polymerase inhibitor for the treatment of hepatitis C. Deleobuvir was tested in combination regimens with pegylated interferon and ribavirin, and in interferon-free regimens with other direct-acting antiviral agents including faldaprevir. Deleobuvir showed that a triple combination of deleobuvir, faldaprevir, and ribavirin performed well in HCV genotype 1b patients. Efficacy fell below 50%, however, for dual regimens without ribavirin and for genotype 1a patients. In December 2013, deleobuvir was discontinued since recent findings from phase III trials did not suggest sufficient efficacy. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BI207127; BI-207127; BI 207127; Deleobuvir; BI-207127NA; BI-207127Na. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 863884-77-9. Molecular formula: C34H33BrN6O3. Mole weight: 653.58. Purity: >98%. IUPACName: (E)-3-(2-(1-(2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carboxamido)cyclobutyl)-1-methyl-1H-benzo[d]imidazol-6-yl)acrylic acid. Canonical SMILES: O=C(O)/C=C/C1=CC=C2N=C(C3(NC(C4=CC5=C(C=C4)C(C6CCCC6)=C(C7=NC=C(Br)C=N7)N5C)=O)CCC3)N(C)C2=C1. Product ID: ACM863884779. Alfa Chemistry ISO 9001:2015 Certified. | |
| Desaminotyrosine | Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-(4-Hydroxyphenyl)Propionic Acid. Product Category: Inhibitors. CAS No. 501-97-3. Molecular formula: C9H10O3. Mole weight: 166.18. Purity: 0.99. Product ID: ACM501973. Alfa Chemistry ISO 9001:2015 Certified. | |
| diABZI STING agonist-1 | diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC 50 s of 130, 186 nM for human and mouse, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 2138299-33-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-112921A. | |
| DiABZI STING agonist-1 | diABZI STING agonist-1 is a selective agonist of stimulator of interferon genes (STING) receptor, with EC50s of 130, 186 nM for human and mouse, respectively. Synonyms: 1H-Benzimidazole-5-carboxamide, 1-[(2E)-4-[5-(aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-; (E)-1-(4-(5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-morpholinopropoxy)-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-methoxy-1H-benzo[d]imidazole-5-carboxamide; STING agonist compound 3; 1-[(2E)-4-[5-(Aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-1H-benzimidazole-5-carboxamide. Grade: >98%. CAS No. 2138299-33-7. Molecular formula: C42H51N13O7. Mole weight: 849.94. | |
| diABZI STING agonist 1 trihydrochloride | diABZI STING agonist-1-trihydrochloride is an agonist of stimulator of interferon genes (STING) for treating cancer. Synonyms: 1H-Benzimidazole-5-carboxamide, 1-[(2E)-4-[5-(aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-, hydrochloride (1:3); (E)-1-(4-(5-Carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-morpholinopropoxy)-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-methoxy-1H-benzimidazole-5-carboxamide tris(hydrochloride); DiABZI. Grade: ≥98%. CAS No. 2138299-34-8. Molecular formula: C42H54Cl3N13O7. Mole weight: 959.32. | |
| diABZI STING agonist-1 trihydrochloride | diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 2138299-34-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112921B. | |
| diABZI-V/C-DBCO | diABZI-V/C-DBCO (Compound 3) is a potent STING agonist. diABZI-V/C-DBCO can release diABZI-amine upon activation by cathepsin B to activate STING, leading to the production of interferons and other immune-stimulatory molecules, thereby enhancing the immune system's response to tumors. The EC50 values for diABZI-V/C-DBCO and diABZI-amine in activating STING in THP1-Dual cells are 1.47 and 0.144 nM, respectively, and in primary mouse splenocytes, the EC50 values are 7.7 and 0.17 ?M, respectively. diABZI-V/C-DBCO can be used in cancer immunotherapy research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3035557-60-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-162874. | |
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