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| Product | Description | |
|---|---|---|
| Interferon aA (human leukocyte protein moietyreduced), N-L-methionyl- (9CI) | Heterocyclic Organic Compound. CAS No. 105388-21-4. Catalog: ACM105388214. |  |
| Interferon-a-IFNa-R Interaction Inhibitor (N-Methyl-1- (2- (naphthalen-1-ylthio) phenyl) methanamine, HCl, N-Methyl-N- (2- (1-naphthylthio) benzyl) amine, HCl, IFN-alpha Inhibitor) | A nonpeptidic thiophenylmethanamine compound that binds interferon-a (Kd= 4uM for human IFN-a) and prevents IFN-a and IFNAR interaction-dependent IFN-a production in murine BM-pDCs (bone marrow-derived plasmacytoid dendritic cells) cultures upon MVA infection (IC50<4.5uM), while exhibiting no inhibitory effect against IL-12 production in the same cultures when applied at non-toxic concentrations (<4.5uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| Interferon alfa | Heterocyclic Organic Compound. Alternative Names: Interferon alfacon-1;Advaferon;Ifn-con1;Infergen. CAS No. 118390-30-0. Catalog: ACM118390300. | |
| interferon α-2b | interferon α-2b. Uses: For analytical and research use. Group: Impurity standards. CAS No. 99210-65-8. Molecular Formula: C19H20N2O. Mole Weight: N/A. Catalog: APB99210658. |  |
| HEPAPEG Pegylated Interferon alpha 2a | Heterocyclic Organic Compound. CAS No. 2002-2-1. Catalog: ACM122. | |
| Pegylated Interferon alpha 2b/2a | Heterocyclic Organic Compound. CAS No. 2003-2-12. Molecular formula: interferon. Catalog: ACM1223. | |
| Ropeginterferon alfa-2b | Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft) is a monopegylated IFN-α that can be used for the research of myeloproliferative neoplasms [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Ropeginterferon alfa-2b-njft; PEG-proline-interferon alpha-2b. CAS No. 1335098-50-4. Pack Sizes: 250 μg. Product ID: HY-P99348. |  |
| 10-Hydroxydecanoic acid | 10-Hydroxydecanoic acid (10-HDAA) is a saturated fatty acid derived from 10-hydroxy-trans-2-decenoic acid, which can be isolated from royal jelly. 10-Hydroxydecanoic acid exhibits various biological activities, including anti-inflammatory, insecticidal, anti-malarial, and anti-Leishmania properties, as well as enhancing antigen-specific immune responses. The anti-inflammatory effects of 10-Hydroxydecanoic acid are primarily mediated by inhibiting the activation of NF-κB and the translation of interferon regulatory factor 1 ( IRF-1 ), which reduces the production of interleukin 6 ( IL-6 ) and nitric oxide ( NO ) in inflammatory cells. Additionally, 10-Hydroxydecanoic acid alleviates neuroinflammatory responses through the p53-autophagy pathway and the p53-NLRP3 pathway. Finally, 10-Hydroxydecanoic acid enhances antigen-specific immune responses by promoting the effective uptake of antigens by microfold cells [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: NSC 15139; 10-HDAA. CAS No. 1679-53-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-Y0148. | |
| 23-c-di-AM(PS)2 (Rp,Rp) | 23-c-di-AM(PS)2 (Rp,Rp) (ADU-S100), an activator of stimulator of interferon genes ( STING ), leads to potent and systemic tumor regression and immunity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ADU-S100; MIW815; ML RR-S2 CDA. CAS No. 1638241-89-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-12885. | |
| 2',3'-cGAMP | 2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 2'-3'-cyclic GMP-AMP. CAS No. 1441190-66-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100564. | |
| 2',3'-cGAMP sodium | 2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 2'-3'-cyclic GMP-AMP sodium. CAS No. 2734858-36-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-100564A. | |
| 2',3'-cGAMP sodium salt | 2',3'-cGAMP sodium is an endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-&beta. 2',3'-cGAMP is an effective adjuvant that boosts the production of antigen-specific antibodies and T cell responses in mice. Synonyms: Cyclic [G(2',5')pA(3',5')p] sodium; cyclic GMP-AMP sodium; 2',3'-cyclic GMP-AMP sodium; 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt. Grades: 95%. CAS No. 2734858-36-5. Molecular formula: C20H22N10Na2O13P2. Mole weight: 718.38. |  |
| AC 264613 | AC 264613 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 7.5). AC 264613 inhibits interferon regulatory factor 5 and decreases interleukin-12p40 production via lipopolysaccharide-stimulated macrophages. PI hydrolysis, Ca2+ mobilization and cellular proliferation are activated by AC 264613 in vitro (pEC50 = 6.9, 7.0 and 7.5, respectively). Synonyms: AC-264613; AC 264613; AC264613; (±)-(3R,4S)-2-Oxo-4-phenyl-3-pyrollidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide. Grades: ≥98% by HPLC. CAS No. 1051487-82-1. Molecular formula: C19H18BrN3O2. Mole weight: 400.27. | |
| ADU-S100 ammonium salt | ML RR-S2 CDA ammonium salt is an inducer of stimulator of interferon genes (STING). It can increases type I interferon production by THP-1 human monocytes relative to unmodified cyclic di-AMP, indicating the ML enhances its action at human STING. Synonyms: MIW815 ammonium salt; ML RR-S2 CDA ammonium salt; [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'?5')-adenosine, cyclic nucleotide, diammonium salt; STING Inducer-1. Grades: 98%. CAS No. 1638750-96-5. Molecular formula: C20H30N12O10P2S2. Mole weight: 724.6. | |
| ADU-S100 disodium salt | ADU-S100 disodium salt (MIW815 disodium salt) is an activator of stimulator of interferon genes (STING) for treating cancer. Synonyms: MIW815 disodium salt; ML RR-S2 CDA disodium salt; 2',3'-c-di-AM(PS)2 (Rp,Rp); Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'?5')-, cyclic nucleotide, sodium salt (1:2); ADU-S 100; MIW 815. Grades: 98%. CAS No. 1638750-95-4. Molecular formula: C20H22N10Na2O10P2S2. Mole weight: 734.51. | |
| Aloeemodin | Aloe-emodin is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71. Aloe-emodin has anti-tumor activity, antibacterial activity, immunosuppressive effect, and purgative effect. It is now widely used as a raw material for medicines and cosmetics. Uses: Antineuroectodermal tumor. Synonyms: 1,8-Dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione; 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone; 3-Hydroxymethylchrysazin; 3-Hydroxymethylchrysazine; Aloe-emodol; NSC 38628; Rhabarberone; Diacerein Impurity B. Grades: >98%. CAS No. 481-72-1. Molecular formula: C15H10O5. Mole weight: 270.24. | |
| Aloe-emodin-[d5] | Aloe-emodin-[d5] is a labelled form of Aloe-emodin. Aloe-emodin is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71. Aloe-emodin has anti-tumor activity, antibacterial activity, immunosuppressive effect, and purgative effect. It is now widely used as a raw material for medicines and cosmetics. Synonyms: 1,8-Dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione-d5; 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone-d5; 3-Hydroxymethylchrysazin-d5; 3-Hydroxymethylchrysazine-d5; Aloe-emodol-d5; NSC 38628-d5; Rhabarberone-d5. CAS No. 1286579-72-3. Molecular formula: C15H5D5O5. Mole weight: 275.27. | |
| Anifrolumab | Anifrolumab is a monoclonal antibody that blocks the activity of type I interferon (IFN). Anifrolumab has been investigated for the treatment of systemic lupus erythematosus (SLE). Synonyms: Saphnelo. CAS No. 1326232-46-5. | |
| Anifrolumab | Anifrolumab is a type I interferon ( IFN ) receptor antagonist, a human monoclonal antibody. Anifrolumab blocks the activity of type I interferon. Anifrolumab can be used in systemic lupus erythematosus (SLE) research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1326232-46-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99168. | |
| AP4A | AP4A is a signal molecule for DNA replication in mammalian cells. AP4A is used as a primer for oligoadenylate synthesis catalyzed by interferon-inducible 2-5A synthetase. AP4A is an inhibitor of eosinophil-derived neurotoxin (EDN). Uses: Ap4a is an inhibitor of eosinophil-derived neurotoxin (edn). Synonyms: (AppppA); P1-(5'-Adenosyl) P4-(5'-adenosyl) tetraphosphate, Sodium salt. Grades: ≥ 95% by HPLC. CAS No. 5542-28-9. Molecular formula: C20H28N10O19P4 (free acid). Mole weight: 836.39 (free acid). | |
| Ascomycin | Ascomycin inhibits the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in target cells.Ascomycin (also known as Immunomycin, FR 900520, and FK-520) is an analog of tacrolimus (FK-506) with immunosuppressive, neurotrophic and antifungal activities. Ascomycin can be used to prevent rejection after an organ transplant, and to treat autoimmune diseases and skin diseases.Ascomycin inhibits the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in target cells. Paul, C., et al. "Ascomycins: promising agents for the treatment of inflammatory skin diseases." Expert Opin. Investig. Drugs. 9: 69-77 (2000). Moll...the compounds." J. Infect. Dis. 191: 1342-1349 (2005).FK-520 might be a substrate for P-glycoprotein; expression of P-glycoprotein in yeast cells resulted in resistance to growth inhibition by FK-520. Raymond, M., et al. "Functional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520." Mol. Cell Biol. 14: 277-286 (1994). Group: Biochemicals. Alternative Names: Immunomycin; FK-520; FR-520; NSC-106410; FR 900520; L 683590; Changchuanmycin. Grades: Highly Purified. CAS No. 104987-12-4. Pack Sizes: 25mg, 50mg, 100mg, 250mg. Molecular Formula: C43H69NO12, Molecular Weight: 792.01. US Biological Life Sciences. | Worldwide |
| Ascomycin (High Purity) (Immunomycin, FK520, Analog of FK-506, FR-900520, L-683590, NSC 106410, WS 7238A) | Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin (protein phosphatase 2B (PP2B)). Suppresses the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant (antiepileptic). Group: Biochemicals. Grades: Highly Purified. CAS No. 104987-12-4. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Avridine | A potent synthetic non-immunogenic adjuvant that can induce arthritis in most rat strains; immunomodulator and interferon-inducing. Group: Biochemicals. Alternative Names: 2, 2'- [ [3- (Dioctadecylamino) propyl] imino] bisethanol; CP 20961; CP-20961; N,N-Dioctadecyl-N',N'-bis(2-hydroxyethyl)-1,3-diaminopropane; N, N-Dioctadecyl-N', N'-bis (2-hydroxyethyl) propanediamine. Grades: Highly Purified. CAS No. 35607-20-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Avridine | Avridine is a potent synthetic non-immunogenic adjuvant that used to induce arthritis in Lewis (LEW) and DA rats. Uses: A potent synthetic non-immunogenic adjuvant that can induce arthritis in most rat strains; immunomodulator and interferon-inducing. Synonyms: CP 20961; CP20961; CP-20961;N,N-Dioctadecyl-N',N'-bis(2-hydroxyethyl)-1,3-diaminopropane. Grades: ≥98%. CAS No. 35607-20-6. Molecular formula: C43H90N2O2. Mole weight: 667.19. | |
| bevacizumab-awwb | Bevacizumab-awwb is the first anti-cancer biosimilar and the first bevacizumab biosimilar approved for the treatment of five types of cancer, including in combination with chemotherapy for non-squamous non-small cell lung cancer (NSCLC), in combination with chemotherapy for metastatic colorectal cancer (mCRC), in combination with interferon alfa for glioblastoma, metastatic renal cell carcinoma and in combination with chemotherapy for persistent, recurrent, or metastatic carcinoma of the cervix. Uses: The traetment of nsclc, etc. Synonyms: Mvasi. | |
| BIT225 | BIT-225 is a NCp7 zinc finger inhibitor potentially for the treatment of HCV infection and HIV infection. BIT225 inhibits HIV-1 replication in myeloid dendritic cells. BIT225, inhibits bovine viral diarrhea virus in vitro and shows synergism with recombinant interferon-alpha-2b and nucleoside analogues. BIT225 against HIV-1 release from human macrophages. Group: Inhibitors. Alternative Names: BIT-225; BIT 225; BIT225. CAS No. 917909-71-8. Molecular formula: C16H15N5O. Mole weight: 293.33. Appearance: Solid powder. Purity: >98%. IUPACName: N-carbamimidoyl-5-(1-methyl-1H-pyrazol-4-yl)-2-naphthamide. Canonical SMILES: O=C (C1=CC=C2C (C3=CN (C)N=C3)=CC=CC2=C1)NC (N)=N. Catalog: ACM917909718. | |
| C-176 | C-176 is a highly potent and selective small-molecule antagonist of the stimulator of interferon genes (STING) protein. It is also a central signaling component of the intracellular DNA sensing pathway. Synonyms: STING inhibitor C 176; C176; C 176. Grades: ≥98%. CAS No. 314054-00-7. Molecular formula: C11H7IN2O4. Mole weight: 358.09. | |
| C-178 | C-178 is a highly potent and selective small-molecule antagonist of the stimulator of interferon genes (STING) protein. It binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. C-178 also blocks palmitoylation (PMA)-induced clustering of STING. It inhibits the CMA-induced phosphorylation of TBK1, which is downstream protein kinase of STING. C-178 prevents the increases in Ifnb1 expression in bone marrow-derived macrophages (BMDMs). Synonyms: C178; C 178. Grades: ≥98%. CAS No. 329198-87-0. Molecular formula: C17H10N2O5. Mole weight: 322.27. | |
| c-(Ap-8-AET-Gp) | c-(Ap-8-AET-Gp) is an analogue of messenger c-(ApGp), the bacterial second, which is used as a ligand for affinity chromatography or for coupling of labelling structures such as fluorophores. c-(ApGp) plays a role in Vibrio choleraepathogenesis and activates the production of interferon via STING. Synonyms: Cyclic (adenosine monophosphate- 8- (2- aminoethylthio)guanosine monophosphate), sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C22H29N11O13P2S (free acid). Mole weight: 749.6 (free acid). | |
| c-(Ap-8-Br-Gp) | c-(Ap-8-Br-Gp) is an analogue of c-(ApGp), the potential bacterial second messenger, which is used for binding studies and as precursor for further modifications with spacers or labels. c-(ApGp) plays a role in Vibrio choleraepathogenesis and activates the production of interferon via STING. Synonyms: Cyclic (adenosine monophosphate- 8- bromoguanosine monophosphate), sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C20H23BrN10O13P2 (free acid). Mole weight: 753.3 (free acid). | |
| c-(Ap-8-Fluo-AET-Gp) | c-(Ap-8-Fluo-AET-Gp) is a fluorescent analogue of c-(ApGp), which can participate in Vibrio choleraepathogenesis and stimulate the production of interferon. Synonyms: Cyclic(adenosine monophosphate-8- (2-[fluoresceinyl]aminoethylthio) guanosine monophosphate), sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C43H39N11O19P2S (free acid). Mole weight: 1107.9 (free acid). | |
| c-(ApIp) | c-(ApIp) is a STING (stimulator of interferon genes)-activating synthetic cyclic dinucleotide (CDN). Synonyms: 3'-Inosinic acid, adenylyl-(3'?5')-, cyclic nucleotide; Cyclic (adenosine monophosphate-inosine monophosphate); cAIMP; CL592; 9-((2R, 3R, 3aS, 7aR, 9R, 10R, 10aS, 14aR)-9-(6-amino-9H-purin-9-yl)-3, 5, 10, 12-tetrahydroxy-5, 12-dioxidooctahydro-2H, 7H-difuro[3, 2-d:3', 2'-j][1, 3, 7, 9]tetraoxa[2, 8]diphosphacyclododecin-2-yl)-1, 9-dihydro-6H-purin-6-one; 1-(6-Amino-9H-purine-9-yl)-1'-(6-hydroxy-9H-purine-9-yl)[3-O,5'-O-(hydroxyphosphinylidene)-5-O,3'-O-(hydroxyphosphinylidene)bis(1-deoxy-beta-D-ribofuranose)]; 3',3'-cAIMP; 3',3'-c(ApIp). Grades: ≥ 95% by HPLC. CAS No. 1507367-51-2. Molecular formula: C20H23N9O13P2. Mole weight: 659.40. | |
| caspase-1 | From mammalian monocytes. This enzyme is part of the family of inflammatory caspases, which also includes caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. Cleaves pro-interleukin-1β (pro-IL-1β) to form mature IL-1β, a potent mediator of inflammation. Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-γ-inducing factor. Inhibited by Ac-Tyr-Val-Ala-Asp-CHO. Caspase-11 plays a critical role in the activation of caspase-1 in mi...proteinase; ICE. Enzyme Commission Number: EC 3.4.22.36. CAS No. 122191-40-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4211; caspase-1; EC 3.4.22.36; 122191-40-6; interleukin 1β-converting enzyme; protease VII; protease A; interleukin 1β precursor proteinase; interleukin 1 converting enzyme; interleukin 1β-converting endopeptidase; interleukin-1β convertase; interleukin-1β converting enzyme; interleukin-1β precursor proteinase; prointerleukin 1β protease; precursor interleukin-1β converting enzyme; pro-interleukin 1β proteinase; ICE. Cat No: EXWM-4211. |  |
| c-di-AMP | c-di-AMP is an agonist of stimulator of interferon genes (STING) for treating cancer. It is a second messenger in bacteria and archaea that is involved in the maintenance of osmotic pressure, response to DNA damage, and control of central metabolism, biofilm formation, acid stress resistance, and other functions. Synonyms: Cyclic diadenylate monophosphate; Cyclic diadenylate; Adenylic acid, cyclic ester; 3',5'-Cyclic diadenylic acid; Cyclic di-3',5'-adenylate; Cyclic di-AMP; Cyclic-di-AMP; Cyclic diadenosine monophosphate; (2R, 3R, 3aS, 7aR, 9R, 10R, 10aS, 14aR)-2, 9-bis(6-amino-9H-purin-9-yl)-3, 5, 10, 12-tetrahydroxyoctahydro-2H, 7H-difuro[3, 2-d:3', 2'-j][1, 3, 7, 9]tetraoxa[2, 8]diphosphacyclododecine 5,12-dioxide. Grades: ≥95%. CAS No. 54447-84-6. Molecular formula: C20H24N10O12P2. Mole weight: 658.41. | |
| cGAMP | cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cyclic GMP-AMP; 3',3'-cGAMP. CAS No. 849214-04-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-12512. | |
| Chlorcyclizine hydrochloride | Chlorcyclizine is a phenylpiperazine that acts as a histamine H1 receptor antagonist (Ki = 9 nM). It is believed to be effective against hepatitis C virus (HCV; EC50 = 44 nM in vitro), targeting viral entry into host cells. Chlorcyclizine showed a synergistic effect with other hepatitis C drugs such as ribavirin, interferon, telaprevir, boceprevir, sofosbuvir, daclatasvir, and cyclosporin A. Synonyms: NSC 169496; Chlorcyclizine HCl; 1-[(4-chlorophenyl)phenylmethyl]-4-methyl-piperazine monohydrochloride. Grades: ≥98%. CAS No. 14362-31-3. Molecular formula: C18H21ClN2·HCl. Mole weight: 337.3. | |
| CL656 | CL656 is an agonist of stimulator of interferon genes (STING) for treating cancer. Synonyms: c-[2'FdAMP(S)-2'FdIMP(S)]; cAIM(PS)2 Difluor (Rp/Sp); Adenosine, 2'-deoxy-2'-fluoro-5'-O-(hydroxymercaptophosphinyl)-P-thioinosinylyl-(3'?5')-2'-deoxy-2'-fluoro-, cyclic nucleotide; CL 656; CL-656; (Rp/Sp) c-[2'FdAM(PS)-2'FdIM(PS]); 9-((2R, 3R, 3aR, 7aR, 9R, 10R, 10aR, 14aR)-9-(6-amino-9H-purin-9-yl)-3, 10-difluoro-12-hydroxy-5-mercapto-5-oxido-12-sulfidooctahydro-2H, 7H-difuro[3, 2-d:3', 2'-j][1, 3, 7, 9]tetraoxa[2, 8]diphosphacyclododecin-2-yl)-1, 9-dihydro-6H-purin-6-one. Grades: >98%. CAS No. 1951464-79-1. Molecular formula: C20H21F2N9O9P2S2. Mole weight: 695.51. | |
| Cyclic GMP | Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. cGMP may also activate PDE to degrade cAMP, inhibit myocardial calcium current I Ca , and regulate myocardial contractility. The derivative of cyclic GMP (cGMP), 8-Br-cGMP, has antiplatelet activity, and cyclic GMP can be used in the study of antiviral immunity and cardiovascular diseases [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 7665-99-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-113469. | |
| cyclic GMP-AMP synthase | Cyclic Gp(2'-5')Ap(3'-5') is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines. Group: Enzymes. Synonyms: cGAMP synthase; cGAS. Enzyme Commission Number: EC 2.7.7.86. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3299; cyclic GMP-AMP synthase; EC 2.7.7.86; cGAMP synthase; cGAS. Cat No: EXWM-3299. | |
| Cyclic GMP sodium | Cyclic GMP (cGAMP) sodium is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP sodium can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP sodium may also activate PDE to degrade cAMP, inhibit myocardial calcium current I Ca , and regulate myocardial contractility. The derivative of Cyclic GMP sodium, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP sodium can be used in the study of antiviral immunity and cardiovascular diseases [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 40732-48-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-113469A. | |
| Dazukibart | Dazukibart is a mouse-derived, humanized IgG1κ antibody targeting interferon beta 1 ( IFNB1 ) [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2639474-65-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990036. | |
| Deleobuvir | Deleobuvir, also known as BI207127, a non-nucleoside hepatitis C virus NS5B polymerase inhibitor for the treatment of hepatitis C. Deleobuvir was tested in combination regimens with pegylated interferon and ribavirin, and in interferon-free regimens with other direct-acting antiviral agents including faldaprevir. Deleobuvir showed that a triple combination of deleobuvir, faldaprevir, and ribavirin performed well in HCV genotype 1b patients. Efficacy fell below 50%, however, for dual regimens without ribavirin and for genotype 1a patients. In December 2013, deleobuvir was discontinued since recent findings from phase III trials did not suggest sufficient efficacy. Group: Inhibitors. Alternative Names: BI207127; BI-207127; BI 207127; Deleobuvir; BI-207127NA; BI-207127Na. CAS No. 863884-77-9. Molecular formula: C34H33BrN6O3. Mole weight: 653.58. Appearance: Solid powder. Purity: >98%. IUPACName: (E)-3-(2-(1-(2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carboxamido)cyclobutyl)-1-methyl-1H-benzo[d]imidazol-6-yl)acrylic acid. Canonical SMILES: O=C (O)/C=C/C1=CC=C2N=C (C3 (NC (C4=CC5=C (C=C4)C (C6CCCC6)=C (C7=NC=C (Br)C=N7)N5C)=O)CCC3)N (C)C2=C1. Catalog: ACM863884779. | |
| Desaminotyrosine | Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling. Group: Inhibitors. Alternative Names: 3-(4-Hydroxyphenyl)Propionic Acid. CAS No. 501-97-3. Molecular formula: C9H10O3. Mole weight: 166.18. Purity: 0.99. Catalog: ACM501973. | |
| diABZI STING agonist-1 | diABZI STING agonist-1 is a selective agonist of stimulator of interferon genes (STING) receptor, with EC50s of 130, 186 nM for human and mouse, respectively. Synonyms: 1H-Benzimidazole-5-carboxamide, 1-[(2E)-4-[5-(aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-; (E)-1-(4-(5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-morpholinopropoxy)-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-methoxy-1H-benzo[d]imidazole-5-carboxamide; STING agonist compound 3; 1-[(2E)-4-[5-(Aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-1H-benzimidazole-5-carboxamide. Grades: >98%. CAS No. 2138299-33-7. Molecular formula: C42H51N13O7. Mole weight: 849.94. | |
| diABZI STING agonist-1 | diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC 50 s of 130, 186 nM for human and mouse, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 2138299-33-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-112921A. | |
| Dinactin | A member of the macrotetrolide complex produced by a range of streptomyces species; a monovalent cation ionophore with high selectivity for ammonium and potassium; inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-&gamma. It is also resistant to gram-positive bacteria and mycobacteria. Synonyms: GNF-Pf-90; Antibiotic 170t; NSC63925; 4, 13, 22, 31, 37, 38, 39, 40-Octaoxapentacyclo(32.2.1.17, 10.116, 19.125, 28)tetracontane-3, 12, 21, 30-tetrone, 5,23-diethyl-2,11,14,20,29,32-hexamethyl-(VAN) (8CI). Grades: >95% by HPLC. CAS No. 20261-85-2. Molecular formula: C42H68O12. Mole weight: 764.98. | |
| Dinactin (Antibiotic AKD 1C, Antibiotic S 3466A) | Dinactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. It is a monovalent cation ionophore with high selectivity for ammonium and potassium. Dinactin inhibited T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-g. Dinactin has not previously been available for intensive investigation. Group: Biochemicals. Alternative Names: Antibiotic AKD 1C, Antibiotic S 3466A. Grades: Highly Purified. CAS No. 20261-85-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| (D)-(+)-Neopterin | Neopterin, a pyrazino-pyrimidine compound derived from GTP, n is a precursor of tetrahydrobiopterin and can be used as a biochemical marker indicative of cell proliferation. Neopterin is synthesized in response to interferon-γ stimulation, and used as a marker of T helper cell-induced immune activation. Neopterin is also an indicator of oxidative stress, and modulates the effects of reactive oxygen species (ROS). Synonyms: 2-Amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-4(3H)-pteridinone; Neopterin; 2-Amino-4-hydroxy-6-(1,2,3-trihydroxypropyl)pteridine; 2-Amino-6-((1S,2R)-1,2,3-trihydroxypropyl)-4(8H)-pteridone; 6-D-erythro-Neopterin; D-(+)-Neopterin; D-erythro-Neopterin. Grades: ≥98% by HPLC. CAS No. 2009-64-5. Molecular formula: C9H11N5O4. Mole weight: 253.21. | |
| Emapalumab | Emapalumab is an anti-interferon-gamma (IFNγ) monoclonal antibody approved for the treatment of primary hemophagocytic lymphohistiocytosis (HLH). Synonyms: Gamifant; NI-0501; NI 0501; NI0501. CAS No. 1709815-23-5. | |
| Ezabenlimab | Ezabenlimab (BI-754091) is an anti- PD-1 mAb with binding constant K d value of 6 nM (CHO cells). Ezabenlimab blocks the interaction of PD-1 with PD-L1 and PD-L2. Ezabenlimab increases interferon-γ secretion in T cells, and inhibits tumor growth in vivo [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BI-754091. CAS No. 2249882-54-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99610. | |
| Frenlosirsen | Frenlosirsen is an interferon regulatory factor 4 (IRF4) synthesis reducer, with antineoplastic properties. Synonyms: all-P-ambo-2'-O,4'-C-[(1S)-ethane-1,1-diyl]-P-thioadenylyl-(3'?5')-2'-O,4'-C-[(1S)-ethane-1,1-diyl]-P-thioguanylyl-(3'?5')-P-thiothymidylyl-(3'?5')-P-thiothymidylyl-(3'?5')-2'-deoxy-P-thioguanylyl-(3'?5')-P-thiothymidylyl-(3'?5')-2'-deoxy-P-thioadenylyl-(3'?5')-2'-deoxy-P-thioadenylyl-(3'?5')-2'-deoxy-P-thioadenylyl-(3'?5')-P-thiothymidylyl-(3'?5')-2'-deoxy-P-thioguanylyl-(3'?5')-2'-O-(2-methoxyethyl)-P-thioadenylyl-(3'?5')-2'-O-(2-methoxyethyl)-P-thioguanylyl-(3'?5')-2'-O-(2-methoxyethyl)-5-methyl-P-thiouridylyl-(3'?5')-2'-O,4'-C-[(1S)-ethane-1,1-diyl]-5-methyl-P-thiocytidylyl-(3'?5')-2'-O,4'-C-[(1S)-ethane-1,1-diyl]guanosine; DNA, d(P-thio)((2',5'-anhydro-6'-deoxy-4'-C-(hydroxymethyl)-alpha-L-mannofurano)A-(3'->4')-(2',5'-anhydro-6'-deoxy-4'-C-(hydroxymethyl)-alpha-L-mannofurano)G-T-T-G-T-A-A-A-T-G-(2'-O-(2-methoxyethyl))rA-(2'-O-(2-methoxyethyl))rG-(2'-O-(2-methoxyethyl))m5rU-(3'->4')-(2',5'-anhydro-6'-deoxy-4'-C-(hydroxymethyl)-alpha-L-mannofurano)m5C-(3'->4')-(2',5'-anhydro-6'-deoxy-4'-C-(hydroxymethyl)-alpha-L-mannofurano)G). CAS No. 2304711-81-5. Molecular formula: C177H226N63O89P15S15. Mole weight: 5605.71. | |
| G150 | G150 is a highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with an IC 50 of 10.2 nM. G150 represses dsDNA-triggered interferon expression, and G150 can be used for the research of inflammatory [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2369751-30-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128583. | |
| Golotimod | Golotimod is an orally bioactive synthetic peptide containing the amino acids D-glutamine and L-tryptophan connected by a gamma-glutamyl linkage with potential immunostimulating, antimicrobial and antineoplastic activities. Golotimod has been shown to inhibit the expression of STAT-3, reversing immunosuppression and stimulating an anti-tumor immune response. It may stimulate the production of T-lymphocytes (in particular the helper T [Th1] cells), activate macrophages, and increase levels of interleukin 2 and interferon gamma. Synonyms: SCV-07; Gamma-D-Glu-L-trp; SCV07; SCV 07; Gamma-D-Glutamyl-L-tryptophan; (2R)-2-amino-5-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid. Grades: >98%. CAS No. 229305-39-9. Molecular formula: C16H19N3O5. Mole weight: 333.34. | |
| GSK2245035 | GSK2245035 is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 has pEC 50 s of 9.3 and 6.5 for IFNα and TFN&alpha. GSK2245035 effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 is used for asthma [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1207629-49-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-118250. | |
| IACS-8779 | IACS-8779 is a highly potent agonist of stimulator of interferon genes (STING) with robust systemic antitumor efficacy. IACS-8779 shows robust activation of the STING pathway in vitro and a superior systemic anti-tumor response in the B16 murine model of melanoma when compared to one of the clinical benchmark compounds. Synonyms: SCHEMBL23046679; 2243079-26-5; AKOS040733407. Grades: >98%. CAS No. 2243079-26-5. Molecular formula: C21H25N9O10P2S2. Mole weight: 689.56. | |
| IACS-8803 | IACS-8803 is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy. Compared to one of the clinical benchmark compounds, it shows robust activation of the STING pathway in vitro and a superior systemic anti-tumor response in the B16 murine model of melanoma. Synonyms: CHEMBL4596454; SCHEMBL22930678; SCHEMBL23710564; 2095690-70-1; AKOS040733408. Grades: >98%. CAS No. 2095690-70-1. Molecular formula: C20H23FN10O9P2S2. Mole weight: 692.53. | |
| IFN-γ Antagonist | IFN-γ Antagonist, derived from the ligand binding site of human γ-interferon (IFN-γ) receptor, is an antagonist of human IFN-γ, and inhibits human IFN-γ-induced expression of HLR/DR antigen on Colo 205 cells with an IC50 of about 35 μM. Synonyms: (Tyr121,Cys(Acm)122)-IFN-γ Receptor (120-141) (human); L-Isoleucine, L-alanyl-L-tyrosyl-S-[(acetylamino)methyl]-L-cysteinyl-L-arginyl-L-α-aspartylglycyl-L-lysyl-L-isoleucylglycyl-L-prolyl-L-prolyl-L-lysyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-arginyl-L-lysyl-L-α-glutamyl-L-α-glutamyl-L-lysyl-L-glutaminyl-; L-alanyl-L-tyrosyl-S-acetamidomethyl-L-cysteinyl-L-arginyl-L-alpha-aspartyl-glycyl-L-lysyl-L-isoleucyl-glycyl-L-prolyl-L-prolyl-L-lysyl-L-leucyl-L-alpha-aspartyl-L-isoleucyl-L-arginyl-L-lysyl-L-alpha-glutamyl-L-alpha-glutamyl-L-lysyl-L-glutaminyl-L-isoleucine; H-Ala-Tyr-Cys(Acm)-Arg-Asp-Gly-Lys-Ile-Gly-Pro-Pro-Lys-Leu-Asp-Ile-Arg-Lys-Glu-Glu-Lys-Gln-Ile-OH. Grades: ≥95%. CAS No. 158040-83-6. Molecular formula: C115H194N34O34S. Mole weight: 2629.04. | |
| IFN-γ Antagonist 1 | IFN-γ Antagonist 1 (AYCRDGKIGPPKLDIRKEEKQI) is an antagonist of interferon γ ( IFN γ ). IFN-γ Antagonist 1 inhibits IFN-γ induced HLR/DR antigen expression in Colon 205 cells with an IC 50 value of approximately 35 μM. IFN-γ Antagonist 1 has potential applications in immune regulation [1]. Uses: Scientific research. Group: Peptides. CAS No. 158040-83-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P4717. | |
| Imiquimod | An agonist of TLR7 with immune response modifying activity, Approved for basal cell carcinoma, In Phase III for VIN and CIN, Imiquimod's proapoptotic activity appears to be related to Bcl-2 overexpression in susceptible tumor cells. Uses: An immune response modifier. it stimulates the production of interferon-a. Synonyms: 1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine; R-837; S-26308; Aldara; TMX-101; 1H-Imidazo[4,5-c]quinolin-4-amine, 1-(2-methylpropyl)-; 1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine; 1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-ylamine; Aldara; Beselna; Keravort; R 837; R837; S 26308; TMX 101; Zartra; Zyclara. Grades: >98%. CAS No. 99011-02-6. Molecular formula: C14H16N4. Mole weight: 240.30. | |
| Imiquimod | Cell-permeable. Topical immune response modifier that displays anti-angiogenic, anti-viral and anti-inflammatory properties. Up-regulates IL-18 and down-regulates MMP-9 through recognition of Toll-like receptor 7 (TLR7) and subsequent activation of MyD88-dependent pathway. Stimulates proinflammatory cytokine production interferon-alpha (IFN-alpha), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) and activates NF-kappaB. Caspase-3 activator that directly induces procaspase-3 cleavage. Anti-cancer compound. Apoptosis inducer. Antiproliferative, independent of immune system activation or function. Approved treatment for external genital warts caused by human papillomavirus infection. Group: Biochemicals. Alternative Names: 1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine; R-837; S-26308. Grades: Highly Purified. CAS No. 99011-02-6. Pack Sizes: 100mg, 250mg, 500mg, 1g. Molecular Formula: C14H16N4. US Biological Life Sciences. | Worldwide |
| Imiquimod Impurity 2 | Imiquimod Impurity 2 is an immune response modifier. It stimulates the production of interferon-a. Synonyms: 3-Hydroxy Imiquimod; 4-Amino-β-methyl-1H-imidazo[4,5-c]quinoline-1-propanol. Grades: > 95%. CAS No. 1807606-78-5. Molecular formula: C14H16N4O. Mole weight: 256.30. | |
| Imiquimod Impurity 4 | Imiquimod Impurity 4 is one of Imiquimod impurities, Imiquimod is an immune response modifier. It stimulates the production of interferon-a. Molecular formula: C15H16N4O. Mole weight: 268.31. | |
| Imiquimod Impurity 5 | Imiquimod Impurity 5 is one of Imiquimod impurities, Imiquimod is an immune response modifier. It stimulates the production of interferon-a. CAS No. 853793-02-9. Molecular formula: C15H18N4. Mole weight: 254.33. | |
| Imiquimod Impurity 6 | Imiquimod Impurity 6 is one of Imiquimod impurities, Imiquimod is an immune response modifier. It stimulates the production of interferon-a. CAS No. 99010-99-8. Molecular formula: C14H15N3O. Mole weight: 241.29. | |
| Ionomycin (Free Acid) | Antibiotic. Potent and highly selective Ca2+ ionophore. Commonly used to modify intracellular calcium levels to study calcium transport across biological membranes and to calibrate fluorescent Ca2+ indicators. Ionomycin also transports Pb2+ and some other divalent cations, as well as several lanthanide series trivalent cations at efficiencies that are greater than or equal to those for Ca2+. Apoptosis inducer. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest at G1 phase and induces central demyelination. Used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2 and IL-4 usually in conjunction with PMA. ADAM10 agonist. Potent inducer of shedding CXCL16. TREK-1 channels inhibitor. PPARy ligand with a unique binding mode. Shows effective glucose-lowering activity in a mouse model of diabetes. Group: Biochemicals. Alternative Names: SQ 23377; EM 94; [2S-[2α[2S*, 5R*(S*)], 5 β(4S*, 6R*, 8R*, 10Z, 12S*, 14S*, 16E, 18S*, 19S*, 20R*, 21R*)]]-11, 19, 21-Trihydroxy-4, 6, 8, 12, 14, 18, 20-heptamethyl-22-[octahydro-5-(1-hydroxyethyl)-2, 5-dimethyl[2, 2-bifuran]-5-yl]-9-oxo-10, 16-docosadienoic Acid; [2S-[2α[2S*, 5R*(S*)], 5 β(4S*, 6R*, 8R*,. Grades: Highly Purified. CAS No. 56092-81-0. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| Mesopram | Mesopram is an orally active, selective phosphodiesterase (PDE) 4 inhibitor. In vitro, mesopram selectively inhibits the activity of type 1 helper T (Th1) cells without affecting cytokine production or proliferation of type 2 helper T (Th2) cells. It decreases the synthesis of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). Some studies conclude that the specific type-4 phosphodiesterase inhibitor mesopram ameliorates murine colitis both in a preventive and a therapeutic setting. Synonyms: (R)-5-(4-Methoxy-3-propoxyphenyl)-5-methyl-2-oxazolidinone. Grades: ≥98% by HPLC. CAS No. 189940-24-7. Molecular formula: C14H19NO4. Mole weight: 265.31. | |
| Modakafusp alfa | Modakafusp alfa (TAK-573) is a humanized, anti-CD38 IgG4 monoclonal antibody fused to 2 attenuated IFNα2b molecules, which delivers interferon-alpha to CD38 -expressing cells. Modakafusp alfa has direct anti-proliferative activity on multiple myeloma (MM) cancer cells in vitro and induces robust and durable antitumor responses in MM xenograft tumor models. Modakafusp alfa in combination with anti-PD-1 antibodies induces immunomodulation and antitumor responses with good tolerance in mice [1] [2] [3] [4]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: TAK-573. CAS No. 2254522-19-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99744. | |
| Monactin (5-demethyl-5-ethylnonactin, Antibiotic AKD 1B) | Monactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. Unlike nonactin, monactin has not previously been available for intensive investigation. Early literature reported that the related dinactin is a monovalent cation ionophore with high selectivity for ammonium and potassium. Monactin inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-gamma. Group: Biochemicals. Alternative Names: 5-demethyl-5-ethylnonactin, Antibiotic AKD 1B. Grades: Highly Purified. CAS No. 7182-54-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| N-Formyl Imiquimod | N-Formyl Imiquimod is one of Imiquimod impurities, Imiquimod is an immune response modifier. It stimulates the production of interferon-a. Synonyms: N-[1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-yl]-formamide. CAS No. 910644-52-9. Molecular formula: C15H16N4O. Mole weight: 268.31. | |
| PD-L1-IN-1 | PD-L1-IN-1 is a potent PD-L1 inhibitor with an IC 50 of 115 nM. PD-L1-IN-1 strongly binds with the PD-L1 protein and challenged it in a co-culture of PD-L1 expressing cancer cells (PC9 and HCC827 cells) and peripheral blood mononuclear cells enhanced antitumor immune activity of the latter. PD-L1-IN-1 significantly increased interferon γ release and apoptotic induction of cancer cells, with low cytotoxicity in healthy cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2767424-13-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139781. | |
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