Intracellular Enzyme Suppliers USA
Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
Product | Description | |
---|---|---|
1,5-Anhydro-D-galactitol Quick inquiry Where to buy Suppliers range | 1,5-Anhydro-D-galactitol, a versatile biomedicine widely employed in managing complications associated with diabetes and ocular cataracts, exhibits exceptional capacity in inhibiting aldose reductase. This enzymatic inhibition effectively hampers the intracellular accumulation of sorbitol. By curbing sorbitol levels, this remarkable compound substantially alleviates diabetic retinopathy and initiates the amelioration of nerve impairments. Moreover, due to its inherent properties, 1,5-Anhydro-D-galactitol showcases promising prospects as a beneficial supplement to the food and pharmaceutical sectors, augmenting its applicability in a multifaceted manner. CAS No. 3971-48-0. Molecular formula: C6H12O5. Mole weight: 164.16. | |
1,9-Dideoxyforskolin Quick inquiry Where to buy Suppliers range | 1,9-Dideoxyforkskolin does not activate adenylyl cyclase and is an inactive analog of Forskolin, a diterpene isolated from Coleus forskohlii, possessing vasodilating and cardiostimulatory properties. Forskolin resensitizes cell receptors by activating the enzyme adenylyl cyclase and increasing the intracellular levels of cAMP. Group: Biochemicals. Grades: Highly Purified. CAS No. 64657-18-7. Pack Sizes: 1mg, 5mg. Molecular Formula: C22H34O5, Molecular Weight: 378.5. US Biological Life Sciences. | Worldwide |
(1R, 4R) -4-[[ (1, 1-Dimethylethoxy) carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester Quick inquiry Where to buy Suppliers range | (1R, 4R) -4-[[ (1, 1-Dimethylethoxy) carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester is an intermediate in synthesizing trans-Abacavir Dihydrochloride (A104995), which is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. Group: Biochemicals. Grades: Highly Purified. CAS No. 168958-19-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C12H19NO4. US Biological Life Sciences. | Worldwide |
(1R,4S)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Quick inquiry Where to buy Suppliers range | (1R,4S)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol is an intermediate used in the synthesis of ent-Abacavir, which is an enantiomer of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. CAS No. 216481-88-8. Molecular formula: C11H12ClN5O. Mole weight: 265.7. | |
2-Chloro-4-nitrophenyl b-D-glucopyranoside Quick inquiry Where to buy Suppliers range | 2-Chloro-4-nitrophenyl b-D-glucopyranoside is a biomedical product used for studying intracellular glucoside transport and enzyme activity. It can serve as a substrate for β-glucosidases, aiding research on drug metabolism and disease mechanisms. This compound's properties can be explored on the websites mentioned to further understand its applications in biomedicine. Synonyms: (2S,3R,4S,5S,6R)-2-(2-Chloro-4-nitrophenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; 2-Chloro-4-nitrophenyl beta-D-glucopyranoside; (2S,3R,4S,5S,6R)-2-(2-CHLORO-4-NITROPHENOXY)-6-(HYDROXYMETHYL)OXANE-3,4,5-TRIOL; 2-Chloro-4-nitrophenyl-D-glucopyranoside; 2-Chloro-4-nitrophenyl-beta-D-glucopyranoside; C12H14ClNO8; MFCD00037475; SCHEMBL3926021; 2-CHLORO-4-NITROPHENYL-BETA-D-GLUCO- PYRANOSIDE*; DTXSID30595373; AKOS016000532; DS-5448; O10057; EN300-6732128; W-200938. CAS No. 120221-14-9. Molecular formula: C12H14ClNO8. Mole weight: 335.69. | |
2'-(R)-Hydroxy-2',3'-dihydroabacavir Dihydrochloride Quick inquiry Where to buy Suppliers range | 2'-(R)-Hydroxy-2',3'dihydroabacavir is the impurity of Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C14H20N6O2 2HCl, Molecular Weight: 304.357291999999. US Biological Life Sciences. | Worldwide |
3,5-Di-O-benzyl-2-deoxy-2-fluoro-D-ribono-1,4-lactone Quick inquiry Where to buy Suppliers range | 3,5-Di-O-benzyl-2-deoxy-2-fluoro-D-ribono-1,4-lactone is an incredibly potent compound extensively utilized in the research of a myriad of ailments, such as neoplastic disorders and viral afflictions. This remarkable compound effectively targets distinct intracellular pathways while obstructing pivotal disease-inducing enzymes. Synonyms: 2-Deoxy-2-fluoro-3,5-bis-O-(phenylmethyl) ribonic acid gamma-lactone. CAS No. 1355049-97-6. Molecular formula: C19H19FO4. Mole weight: 330.35. | |
5-(Pentafluorobenzoylamino)fluoroscein di-b-D-galactopyranoside Quick inquiry Where to buy Suppliers range | 5-(Pentafluorobenzoylamino)fluoroscein di-b-D-galactopyranoside is an indispensable biomedical research compound, showcasing multifaceted fluorescence attributes positioning it as an adaptable fluorescent probe, lending itself to a myriad of biochemical and cellular assays. By exploring glycosidase activity and evaluating intracellular enzymatic activity, this compound enables breakthroughs in compound. Molecular formula: C39H32F5NO16. Mole weight: 865.67. | |
6-Azauracil Quick inquiry Where to buy Suppliers range | 6-Azauracil inhibits enzymes in nucleoside synthesis and depletes the intracellular GTP/UTP pool. It is being used to identify mutations in transcriptional elongation machinery, as well as mutations in a variety of other pathways. Uses: Inhibits enzymes in nucleoside synthesis and depletes the intracellular gtp/utp pool. Synonyms: 2H-1,2,4-triazine-3,5-dione. Grades: ≥ 98 %. CAS No. 461-89-2. Molecular formula: C3H3N3O2. Mole weight: 113.07. | |
8-[(6-Amino)hexyl]-amino-adenosine-3',5'-bisphosphate - ATTO-633 Quick inquiry Where to buy Suppliers range | 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-bisphosphate - ATTO-633 is a remarkable and potent fluorescent probe harnessed in the realm of biomedical research, unveiling new horizons for comprehending cellular signaling pathways and deciphering enzymatic activities. Embracing a pivotal role in fluorescence microscopy and flow cytometry applications, it solidifies its position as a prime facilitator in the exploration of compound interactions, receptor-ligand bonds and intracellular calcium kinetics. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-bisphosphate, labeled with ATTO 633, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H29N7O10P2- ATTO 633 (free acid). Mole weight: 1074.39 (free acid). | |
A-740003 Quick inquiry Where to buy Suppliers range | A-740003 is potent, selective and competitive P2X7 receptor antagonist. Its IC50 values are 18 and 40 nM for rat and human receptors respectively measured by agonist-stimulated changes in intracellular calcium concentrations. It displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 μM. It reduces nociception in animal models of persistent neuropathic and inflammatory pain. It showed weak or no activity (IC(50) > 10 muM) at other P2 receptors and an array of other neurotransmitter and peptide receptors, ion channels, reuptake sites, and enzymes. It potently blocked agonist-evoked IL-1beta release (IC(50) = 156 nM) and pore formation (IC(50) = 92 nM) in differentiated human THP-1 cells. It produces significant antinociception in animal models of neuropathic and inflammatory pain in vivo. Uses: A-740003 produces significant antinociception in animal models of neuropathic and inflammatory pain in vivo. Synonyms: A-740003; A 740003; A740003; N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide;N-(1-{[(cyanoimino)(5-quinolinylamino) methyl] amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide. Grades: >98 %. CAS No. 861393-28-4. Molecular formula: C26H30N6O3. Mole weight: 474.55. | |
Abacavir 5'-(2,3,4-Tri-O-isobytyryl)-β-D-glucuronic Acid Methyl Ester Quick inquiry Where to buy Suppliers range | Abacavir 5'-(2,3,4-Tri-O-isobytyryl)-β-D-glucuronic Acid Methyl Ester is an intermediate used in the synthesis of various Abacavir metabolites. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. Molecular formula: C33H46N6O10. Mole weight: 686.75. | |
Abacavir 5'-4-Chloro-6-methylpyrimidine-2,5-diamine Quick inquiry Where to buy Suppliers range | Abacavir 5'-4-Chloro-6-methylpyrimidine-2,5-diamine (Abacavir EP Impurity B) is a degradation product of Abacavir Sulfate. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. Synonyms: N6-Cyclopropyl-9-((1R,4S)-4-(((2,5-diamino-6-chloropyrimidin-4-yl)oxy)methyl)cyclopent-2-en-1-yl)-9H-purine-2,6-diamine; Abacavir USP Related Compound D; Abacavir EP Impurity B; Abacavir Impurities; Abacavir EP Impurity B. CAS No. 1443421-69-9. Molecular formula: C18H21ClN10O. Mole weight: 428.88. | |
Adenosine 5'-triphosphate trisodium salt Quick inquiry Where to buy Suppliers range | Adenosine 5'-triphosphate trisodium salt is a vital compound widely used in the biomedical industry. It serves as an essential energy carrier and intracellular signaling molecule. ATP trisodium salt is commonly utilized in research and enzymatic assays requiring ATP supplementation. Synonyms: 5'-ATP Na3. CAS No. 20978-32-9. Molecular formula: C10H15N5O13P3Na3. Mole weight: 575.14. | |
Adenylyl-(3'-5')-adenosine monoammonia salt Quick inquiry Where to buy Suppliers range | Adenylyl-(3'-5')-adenosine monoammonia salt is a vital compound utilized in biomedical research. It is commonly employed for studying intracellular signaling pathways and second messengers, including cAMP (cyclic adenosine monophosphate). This product plays a crucial role in investigating the activation and regulation of various enzymes, receptors, and ion channels involved in multiple diseases, such as cancer, cardiovascular disorders, and neurological conditions. Its high purity and quality ensure accurate and reliable experimental results. Synonyms: ADENYLYL(3'-5')ADENOSINE; APA. Grades: 95%. CAS No. 102029-96-9. Molecular formula: C20H25N10O10P.NH3. Mole weight: 613.48. | |
Ammonium Chloride Quick inquiry Where to buy Suppliers range | Ammonium chloride is used as an acidifier in oral preparations. It is also used as a food additive and preservative, and as an expectorant in cough medicines. It can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor. Synonyms: Ammonium muriate; E510; Sal ammoniac; Salmiac; Salammoniac. Grades: 95%. CAS No. 12125-02-9. Molecular formula: ClH4N. Mole weight: 53.49. | |
Angiotensin II (1-4), human Quick inquiry Where to buy Suppliers range | Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels. Angiotensin II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney. Uses: Peptide Inhibitors. CAS No. 52580-29-7. Product ID: R1200. | |
AS-605240 potassium salt Quick inquiry Where to buy Suppliers range | Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. AS-605240 inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively. AS-605240 also inhibits C5a-mediated phosphorylation of protein kinase B in RAW 264 cells with an IC50 value of 90 nM. AS-605240 potassium salt is the potassium salt form of AS-605240, which increase the water-solubility. Synonyms: AS-605240. Grades: ≥98%. Molecular formula: C12H6N3O2S·K. Mole weight: 295.4. | |
Asp-Phe Quick inquiry Where to buy Suppliers range | L-Aspartyl-L-phenylalanine is a dipeptide inhibitor of angiotensin-converting enzyme (ACE) and a metabolite of the synthetic non-caloric sweetener aspartame. It is formed from aspartame by intestinal intracellular esterases. L-Aspartyl-L-phenylalanine inhibits ACE with a Ki value of 11 µM for the rabbit enzyme. Serum levels of L-aspartyl-L-phenylalanine are positively associated with pancreatic ductal adenocarcinoma. Uses: API. CAS No. 13433-09-5. Product ID: 10-101-305. | |
ATIC Dimerization Inhibitor (Ac-Arg-Ph(4-NO2)-NEt2, ATIC Inhibitor, AICAR Tfase Inhibitor, AICAR Transformylase Inhibitor, AICAR Tranformylase/Inosine Monophosphate Cyclohydrolase Dimerization Inhibitor, AMPK Signaling Activator XI) Quick inquiry Where to buy Suppliers range | A cell-permeable dipeptide that reversibly blocks the homodimerization of aminoimidazole carboxamide ribonucleotide transformylase/inosine nomophosphate cyclohydrolase (ATIC) and inhibits its activity (Ki = 691nM, Kd = 240nM). AITC is a bifunctional enzyme that catalyzes the last two steps of de novo purine biosynthesis. Increases the intracellular levels of AICAR leading to the activation of AMP-activated protein kinase (AMPK). Shown to reduce cell viability in a dose-dependent manner. Exhibits a longer half-life and sustained AMPK activation (~24h), compared to AICA-riboside. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
cAMP (Cyclic Adenosine Monophosphate, Cyclic AMP, Adenosine 3'5'-cyclic Monophosphate) (HRP) Quick inquiry Where to buy Suppliers range | Cyclic Adenosine Monophosphate is a hydrophilic secondary messenger that is part of the cellular signal transduction pathway. It is produced by enzymatic methods on the molecule ATP by the enzyme adenylyl cyclase. It interacts with receptor proteins on the surface of a cell membrane following an intracellular signal produced by hormones or neurotransmitters. Cyclic AMP activates Protein Kinase A (PKA) catalytic ability. This activated PKA molecule transfers phosphate from ATP to different amino acid sequences. These phosphorylated amino acids can regulate calcium ion channels allowing calcium to move across the cellular membrane. Group: Biochemicals. Grades: Purified. Pack Sizes: 500ul. US Biological Life Sciences. | Worldwide |
CAY10626 Quick inquiry Where to buy Suppliers range | Phosphatidylinositol 3-kinases (PI3K) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. PI3K catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. CAY10626 demonstrates IC50 values of <3 and 13 nM for MDA361 (breast) and PC3 (prostate) cancer cell lines, respectively. Synonyms: CAY 10626; CAY-10626. Grades: ≥98%. CAS No. 1202884-94-3. Molecular formula: C31H35F3N8O3. Mole weight: 624.7. | |
cis-rac-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride Quick inquiry Where to buy Suppliers range | cis-rac-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride is an intermediate of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. Synonyms: (1R,4S)-rel-4-(2-Amino-6-chloro-9H-purin-9-yl)2-cyclopentene-1-methanol Hydrochloride. CAS No. 267668-74-6. Molecular formula: C11H12ClN5O HCl. Mole weight: 265.7. | |
cis-rac-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride Quick inquiry Where to buy Suppliers range | cis-rac-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. Group: Biochemicals. Grades: Highly Purified. CAS No. 267668-74-6. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C11H12ClN5O HCl, Molecular Weight: 265.7. US Biological Life Sciences. | Worldwide |
Cyclosporin Quick inquiry Where to buy Suppliers range | It is produced by the strain of Polypocladiurn inflatum. It has a strong immunosuppressive action, but also has anti-inflammatory and weak antifungal effects. The mechanism of immunosuppression is the combination of cyclosporin A and cyclosporin-binding protein in T cells, which inhibits the activity of Calcineurin, and then impedes the transposition of intracellular transcription factors into the nucleus, and inhibits the interleukin-2 transcription, resulting in immunosuppression. It is mainly used for kidney transplantation, bone marrow and heart transplantation, and is one of the most important immunosuppressive agents in clinical application. Uses: Enzyme inhibitors. Synonyms: Restasis; Cyclosporine; Gengraf; Sandimmune; SangCyA; Atopica. Grades: >98%. CAS No. 79217-60-0. Molecular formula: C62H111N11O12. Mole weight: 1202.61. | |
Cystamine dihydrochloride Quick inquiry Where to buy Suppliers range | Cystamine dihydrochloride is the dihydrochloride salt of cystamine, which is an organic disulfide that inhibits tissue transglutaminase (TGM2) with an IC50 value of approximately 2.5 mM. It is orally available, and decreases aggregated and cross-linked huntingtin in transfected cells. It is neuroprotective in mouse models of Huntington's disease. It has exhibited suppressive effects against HIV replication in infected human cells. It could extend survival and improve motor performance in transgenic HD mice. It inhibits caspase 3, increases intracellular glutathione, and reduces inflammation in a rat model of inflammatory bowel disease. Uses: Enzyme inhibitors. Synonyms: 2-(2-aminoethyldisulfanyl)ethanamine; dihydrochloride. Grades: > 97 %. CAS No. 56-17-7. Molecular formula: C4H14Cl2N2S2. Mole weight: 225.20. | |
ent-Abacavir Quick inquiry Where to buy Suppliers range | ent-Abacavir (Abacavir EP Impurity A) is an enantiomer of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. Uses: Anti-hiv agents. Synonyms: (1R,4S)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol;(1R-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; (1R,4S)-Abacavir; Abacavir EP Impurity A; Abacavir Impurities; Ent-Abacavir. Grades: 97%. CAS No. 136470-79-6. Molecular formula: C14H18N6O. Mole weight: 286.33. | |
Falnidamol Quick inquiry Where to buy Suppliers range | Falnidamol, also known as BIBX 1382, is a pyrimido-pyrimidine with antitumor activity. BIBX 1382 inhibits the intracellular tyrosine kinase domain of the Epidermal Growth Factor Receptor (EGFR) thus specifically reversing the aberrant enzymatic activity from overexpressed and constitutively activated EGFR, and subsequently inhibiting cell proliferation and inducing cell differentiation. Synonyms: BIBX 1382; BIBX1382; BIBX-1382; BIBX 1382BS; BIBX1382BS; BIBX-1382BS; Falnidamol. CAS No. 196612-93-8. Molecular formula: C18H19ClFN7. Mole weight: 387.847. | |
Forskolin Quick inquiry Where to buy Suppliers range | Forskolin is a diterpene isolated from Coleus forskohlii, possessing vasodilating and cardiostimulatory properties. Forskolin resensitizes cell receptors by activating the enzyme adenylyl cyclase and increasing the intracellular levels of cAMP. Group: Biochemicals. Alternative Names: (3R, 4aR, 5S, 6S, 6aS, 10S, 10aR, 10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6, 10, 10b-trihydroxy-3, 4a, 7, 7, 10a-pentamethyl-1H-Naphtho[2, 1-b]pyran-1-one; (-)-Forskolin; Coleonol; Colforsin; ForsLean; HL 362; L 75-1362B; NSC 357088. Grades: Highly Purified. CAS No. 66575-29-9. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
γ-(6-Aminohexyl)-ATP - ATTO-700 Quick inquiry Where to buy Suppliers range | γ-(6-Aminohexyl)-ATP - ATTO-700, a fluorescent ATP analog, is frequently utilized in biomedical investigations to decipher ATP-dependent enzymes and signaling pathways. This unique product serves as an optimal solution for imaging intracellular ATP levels and monitoring ATP-dependent cellular processes. In particular, it proves valuable in the study of cancer research, where targeting ATP-dependent enzymes and pathways paves the way for developing novel cancer therapies. Synonyms: γ-(6-Aminohexyl)-adenosine-5'-triphosphate, labeled with ATTO 700, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C16H29N6O13P3- ATTO 700 (free acid). Mole weight: 1153.35 (free acid). | |
γ-(6-Aminohexyl)-GTP - ATTO-488 Quick inquiry Where to buy Suppliers range | γ-(6-Aminohexyl)-GTP - ATTO-488, being a highly versatile fluorescent nucleotide analog, offers a noteworthy contribution in facilitating the scientific probing of intracellular enzyme kinetics and protein interactions. This exemplary product crucially aids researchers in unraveling the concealed root causes of GTPases and G protein-coupled receptors (GPCRs) as its fluorescence properties efficaciously enhances the visual detection of GTP hydrolysis and protein-protein interactions. Synonyms: γ-(6-Aminohexyl)-guanosine-5'-triphosphate, labeled with ATTO 488, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C41H50N9O23P3S2(free acid). Mole weight: 1193.17 (free acid). | |
Guanosine 5'-triphosphate Quick inquiry Where to buy Suppliers range | Guanosine triphosphate (GTP) is a guanine nucleotide containing three phosphate groups esterified to the sugar moiety. GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA. Synonyms: D-Guanosine 5'-triphosphate; Guanosine triphosphate; Guanosine 5'-triphosphoric acid; pppG; guanosine 5'-O-(triphosphate); [[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate. Grades: ≥98% by AX-HPLC. CAS No. 86-01-1. Molecular formula: C10H16N5O14P3. Mole weight: 523.18. | |
Iron Chelator IV, 21H7 (6-Bromo-N-(2-hydroxybenzylidene)-2-methylquinoline-4-carbohydrazide) Quick inquiry Where to buy Suppliers range | A cell-permeable salicylaldehyde-acylhydrazone iron chelator that is 20-times more efficient than DFO/desferrioxamine in depleting intracellular iron in colon cancer SW480 cells. Iron chelators exert their biological activities by affecting iron-regulated enzymes and singaling events, including HIF1a transcription activation due to inhibition of PHD- (prolyl hydroxylase) mediated HIF1a degradation, as well as altered mRNA translations due to enhanced IRP (Iron Regulatory Protein) IREs (Iron Response Elements) binding. Cellular iron depletion is also reported to inhibit the growths of colorectal adenocarcinoma cultures, DLD-1 (IC50=0.6 and 2.9uM, respectively, by 21H7 and DFO) and SW480 (IC50=1.0 and 3.8uM, respectively, by 21H7 and DFO), as a result of Wnt signaling pathway blockage (Effective conc.=5uM 21H7 or 100uM DFO). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Lanreotide Quick inquiry Where to buy Suppliers range | Laromustine is a sulfonyl hydrazine prodrug with antineoplastic activity. Laromustine releases the DNA chloroethylating agent 90CE after entering the blood stream; 90CE chloroethylates alkylates the 06 position of guanine, resulting in DNA crosslinking, strand breaks, chromosomal aberrations, and disruption of DNA synthesis. Intracellular metabolism of this agent also releases methyl isocyanate which inhibits 06-alkyl-guanine transferase, an enzyme involved with DNA repair. Synonyms: Angiopeptin; Autogel; BIM 23014; DC 13-116; Dermopeptin; Ipstyl; L-Autogel; Lanreotide Autogel; Somatulin; Somatulin-Autogel; Somatuline Depot; L-Threoninamide, 3-(2-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-, cyclic (2?7)-disulfide; H-D-2Nal-Cys(1)-Tyr-D-Trp-Lys-Val-Cys(1)-Thr-NH2; 3-(2-naphthyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-L-threoninamide (2->7)-disulfide. Grades: 98%. CAS No. 108736-35-2. Molecular formula: C54H69N11O10S2. Mole weight: 1096.33. | |
Leu-D-Leu Quick inquiry Where to buy Suppliers range | Leu-D-Leu is a specific substrate for D-peptidase S, an intracellular carboxypeptidase-like enzyme that preferentially hydrolyzes dipeptides containing hydrophobic D-amino acids. Synonyms: l-Leucyl-d-leucine; D-Leucine, L-leucyl-; N-L-Leucyl-D-leucine; (R)-2-((S)-2-amino-4-methylpentanamido)-4-methylpentanoic acid. CAS No. 17665-02-0. Molecular formula: C12H24N2O3. Mole weight: 244.33. | |
Nicotianamine Quick inquiry Where to buy Suppliers range | Phytosiderophores are produced in higher plants as iron chelating amino acids that promote uptake of iron from soil. Nicotianamine is a metal chelator and phytosiderophore precursor produced in plants that has a role in the uptake, translocation, and intracellular transport of metals.1 Treating lettuce (L. sativa) with a Cu(OH)2-based pesticide raises nicotianamine levels 12- to 27-fold compared to non-pesticide treated plants.2 Nicotianamine also inhibits rabbit angiotensin-coverting enzyme (ACE) (IC50 = 0.26 μM) and human recombinant ACE2 (IC50 = 84 nM).3,4. Group: Biochemicals. Alternative Names: (αS,2S)-α-[[(3S)-3-Amino-3-carboxypropyl]amino]-2-carboxy-1-azetidinebutanoic Acid; [2S-[1[αR*(R*)], 2R*]]-α-[(3-Amino-3-carboxypropyl)amino]-2-carboxy- 1-azetidinebutanoic Acid. Grades: Highly Purified. CAS No. 34441-14-0. Pack Sizes: 1mg. Molecular Formula: C12H21N3O6, Molecular Weight: 303.31. US Biological Life Sciences. | Worldwide |
NK314 Quick inquiry Where to buy Suppliers range | NK314 is a novel synthetic benzo[c]phenanthridine alkaloid that shows strong antitumor activity. It inhibited topoisomerase II activity and stabilized topoisomerase II-DNA cleavable complexes. The DNA breaks occurred within 1h after treatment with NK314 even without digestion of topoisomerase II by proteinase K, whereas etoposide required digestion of the enzyme protein in cleavable complex to detect DNA breaks. Pretreatment with topoisomerase II catalytic inhibitors, ICRF-193 and suramin, reduced both cleavable complex-mediated DNA breaks and proteinase K-independent DNA breaks, but protease inhibitors and nuclease inhibitors only decreased the latter. These results indicate that NK314 might affect topoisomerase II in the different manner from cleavable complex formation and activate intracellular proteinase and nuclease to produce DNA fragmentation. As a result of this unique mechanism of DNA breakage, NK314 showed substantial growth inhibition of topoisomerase II inhibitor-resistant tumors. Synonyms: NK-314; NK 314. Grades: 98%. CAS No. 208237-49-4. Molecular formula: C22H18ClNO4. Mole weight: 395.84. | |
PKM2 Activator III (N- (4- (4- (2-Methoxyphenyl) piperazine-1-carbonyl) phenyl) quinoline-8-sulfonamide, Pyruvate Kinase M2 Activator III) Quick inquiry Where to buy Suppliers range | A cell-permeable quinoline-sulfonamide that acts as a potent allosteric PKM2 activator both in cell-free enzymatic assays (AC50 = 17nM with 40ng PKM2/200ul) and in cultures (AC50 = 45nM in A549 cells) via a high affinity, 2:1 stoichiometric binding, effectively locking PKM2 in an active tetrameric state resistant to known intracellular negative regulators of FBP-activated PKM2 tetramer. PKM2 stimulation by compound treatment is shown to result in decreased serine biosynthesis (by 56%; 500nM for 24h) with concomitant increase in serine influx as a compensating mechanism for maintaining cellular serine level necessary for supporting A549 proliferation. Simultaneous PKM2 activation and culture serine withdrawal results in cytostatic A549 growth arrest, but not apoptosis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
rac-Abacavir Sulfate Quick inquiry Where to buy Suppliers range | rac-Abacavir Sulfate is a racemic mixture of ent-Abacavir and Abacavir Sulfate. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. Synonyms: Abacavir Sulfate Racemic; (4-[2-Amino-6-(cyclopropylamino)-9H-purin-9yl]-2-cyclopentene-1-methanol Sulfate (2:1). Molecular formula: C28H38N12O6S. Mole weight: 670.47. | |
Thapsigargin Quick inquiry Where to buy Suppliers range | Potent, cell-permeable, IP3-independent intracellular calcium releaser. Blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. Induces apoptosis by disrupting intracellular free Ca2+ levels; incorporated into chemotherapeutic prodrug formulations. In cells, sarco/endoplasmic calcium ATPases (SERCAs) transport free calcium into the sarcoplasmic and endoplasmic reticula, lowering intracellular calcium levels to stop signaling through this cation. Thapsigargin is a non-competitive, cell permeable inhibitor of calcium transport by SERCAs (IC50 values are cell type-dependent and range from ~2-80 nM). Inhibition of SERCAs leads to an increase in intracellular calcium, which has been linked to cell activation, release of histamine from mast cells, and increased proliferation of certain types of cancer cells. In vivo, thapsigargin and related sesquiterpene lactones have anti-inflammatory and anti-cancer effects. Uses: Enzyme inhibitors. Synonyms: Octanoic acid. Grades: >99%. CAS No. 67526-95-8. Molecular formula: C34H50O12. Mole weight: 650.75. | |
Tiazofurin Quick inquiry Where to buy Suppliers range | Tiazofurin is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin (TR) is anabolized intracellularly to an analogue of NAD, tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH); IMPDH is the rate-limiting enzyme for de novo purine synthesis. Inhibition of IMPDH results in reduced levels of guanylates, resulting in the inhibition tumor cell growth in vitro and in vivo. Uses: Antineoplastic agents. Synonyms: 2-b-D-Ribofuranosyl-4-thiazolecarboxamide; CI 909; NSC 286-193. Grades: 97%. CAS No. 60084-10-8. Molecular formula: C9H12N2O5S. Mole weight: 260.27. | |
trans-Abacavir Dihydrochloride Quick inquiry Where to buy Suppliers range | trans-Abacavir Dihydrochloride is an impurity of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. Synonyms: (1R,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Diydrochloride. Grades: 98%. Molecular formula: C14H20Cl2N6O. Mole weight: 359.25. |