Jun Kinase Suppliers USA
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Product | Description | |
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SAPK1, JNK (Stress Activated Protein Kinase, Jun Kinase) Control Cell Extracts Quick inquiry Where to buy Suppliers range | The SAPK/JNK pathway is homologous to the MAPK pathway in its overall form but is activated by largely distinct stimuli (1). A variety of extracellular stimuli activate the JNK/SAPK pathway including inflammatory cytokines, UV light, inhibitors of protein synthesis and osmotic stress (1-5). Inflammatory cytokines such as TNFa and IL1 appear to activate this pathway via the Rac/Rho family of small GTP binding proteins, whereas inhibitors of protein synthesis and UV light appear to act independently of Rho and Rac (6). Activated MEKK1 phosphorylates SEK1 (also known as MKK4), which in turn activates SAPK (also known as JNK). SAPK binds tightly to the N-terminal region of c-Jun and ATF-2. It phosphorylates c-Jun at Ser63 and Ser73, and ATF-2 at Thr69 and Thr71 (5). Group: Biologicals. Grades: Lysate. Pack Sizes: 10Blots. US Biological Life Sciences. | Worldwide |
C-Jun-amino-terminal kinase-interacting protein 2 (683-692) Quick inquiry Where to buy Suppliers range | C-Jun-amino-terminal kinase-interacting protein 2. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-068. | |
1-Methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-en-1-yl)piperazine Quick inquiry Where to buy Suppliers range | 1-Methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-en-1-yl)piperazine is a reactant used in the preparation of azaindole derivatives as c-Jun N-terminal kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1046793-62-7. Pack Sizes: 250mg, 2.5g. Molecular Formula: C17H31BN2O2, Molecular Weight: 306.25. US Biological Life Sciences. | Worldwide |
2-(1-Hexyn-1-yl)benzoic Acid Quick inquiry Where to buy Suppliers range | 2-(1-Hexyn-1-yl)benzoic Acid is an intermediate in synthesizing Apigenin 5-O- β-D-Glucuronide (A426510), a metabolite of Apigenin (A726500), Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 uM) by inhibiting MAP kinase activity. Also inhibits the proliferation of malignant tumor cells by G2/M arrest and induces morphological differentiation. Apigenin has also been reported to enhance the gap junction intracellular communication in liver cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 120870-47-5. Pack Sizes: 250mg, 500mg. Molecular Formula: C13H14O2. US Biological Life Sciences. | Worldwide |
2,5-Dibromobenzoic Acid Quick inquiry Where to buy Suppliers range | 2,5-Dibromobenzoic Acid is an intermediate used to prepare benzo[c]chromenone and benzo[c]chromene derivatives as estrogen β-receptor-selective agonists in comparison with effusol and estradiol. It is also used in the synthesis of aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 610-71-9. Pack Sizes: 1g, 5g. Molecular Formula: C7H4Br2O2, Molecular Weight: 279.91. US Biological Life Sciences. | Worldwide |
2-Methylmercaptoethanol Quick inquiry Where to buy Suppliers range | 2-Methylmercaptoethanol is an intermediate used to prepare aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activities and minimal cross-kinase activities. It is also used to prepare methionine analogs as inhibitors of methionyl-tRNA synthetase with antimicrobial activities. Group: Biochemicals. Grades: Highly Purified. CAS No. 5271-38-5. Pack Sizes: 1g, 10g. Molecular Formula: C3H8OS, Molecular Weight: 92.16. US Biological Life Sciences. | Worldwide |
3-Bromo-4-fluoro-benzoic Acid Ethyl Ester Quick inquiry Where to buy Suppliers range | 3-Bromo-4-fluoro-benzoic Acid Ethyl Ester is used to prepare 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents. It is also used to synthesize Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38. Group: Biochemicals. Grades: Highly Purified. CAS No. 23233-33-2. Pack Sizes: 1g, 5g. Molecular Formula: C9H8BrFO2, Molecular Weight: 247.06. US Biological Life Sciences. | Worldwide |
3-Nitropropionic Acid Quick inquiry Where to buy Suppliers range | A cell-permeable, irreversible inactivator (~3mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38mg/kg/day) is shown to cause activation of c-Jun kinase in striatum. Group: Biochemicals. Alternative Names: 3-NP, 3-NPA, 3NPA. Grades: Highly Purified. CAS No. 504-88-1. Pack Sizes: 50mg. Molecular Formula: C?H?NO?. US Biological Life Sciences. | Worldwide |
AEG 3482 Quick inquiry Where to buy Suppliers range | AEG 3482 has been found to be an inhibitor of c-jun N-terminal kinase (JNK) signaling and could probably be useful against some neurological disorders. Synonyms: AEG-3482; AEG 3482; AEG3482; 6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide. Grades: ≥99% by HPLC. CAS No. 63735-71-7. Molecular formula: C10H8N4O2S2. Mole weight: 280.33. | |
Apigenin-d5 7-Glucuronide Quick inquiry Where to buy Suppliers range | Apigenin-d5 7-Glucuronide is labelled Apigenin 7-Glucuronide (A726505), a metabolite of Apigenin, which induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 uM) by inhibiting MAP kinase activity. Also inhibits the proliferation of malignant tumor cells by G2/M arrest and induces morphological differentiation. Apigenin has also been reported to enhance the gap junction intracellular communication in liver cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C21H13D5O11, Molecular Weight: 451.39. US Biological Life Sciences. | Worldwide |
BI 78D3 Quick inquiry Where to buy Suppliers range | BI 78D3 is a competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 = 280 nM) with > 100 fold selectivity over p38α and no effect on mTOR and PI-3K. BI 78D3 inhibits JNK interacting protein 1 (JIP1) binding to JNK (IC50 = 500 nM) and prevents JNK substrate phosphorylation. It blocks JNK-dependent Con A-induced liver damage and also restores insulin sensitivity in a mouse model of type II diabetes. Synonyms: JNK Inhibitor X; BI-78D3; BI78D3; BI 78D3; 4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]-3H-1,2,4-triazol-3-one. Grades: ≥99% by HPLC. CAS No. 883065-90-5. Molecular formula: C13H9N5O5S2. Mole weight: 379.37. | |
CC-401 Quick inquiry Where to buy Suppliers range | CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. The activation of JNK signaling is indentified in many immune-mediated kidney disease models. Thus, as the JNK inhibitor, CC-401 is found to be effective in these renal injury models. Synonyms: CC-401; CC 401; CC401. Grades: >98%. CAS No. 395104-30-0. Molecular formula: C22H24N6O. Mole weight: 388.47. | |
CEP 1347 Quick inquiry Where to buy Suppliers range | Inhibitor of c-jun N-terminal kinase (JNK) signaling. Rescues motor neurons undergoing apoptosis (EC50 = 20nM). Blocks A β-induced cortical neuron apoptosis (EC50 ~51nM). Does not inhibit ERK1 activity. Neuroprotective. Group: Biochemicals. Alternative Names: (9S,10R,12R)-5-16-Bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester. Grades: Highly Purified. CAS No. 156177-65-0. Pack Sizes: 1mg. Molecular Formula: C33H33N3O5S2.1?2H2O, Molecular Weight: 624.77. US Biological Life Sciences. | Worldwide |
Chelerythrine chloride Quick inquiry Where to buy Suppliers range | Cell permeable potent inhibitor of protein kinase C. Does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase or calcium/calmodulin-dependent protein kinase. Antiplatelet, anti-inflammatory, antibacterial and antitumor compound. Apoptosis inducer in cancer cells in vitro and in vivo. Activates MAPK and JUNK signaling pathways. Affects translocation of PKC from cytosol to plasma membrane. Neurite outgrowth stimulator. Inhibits binding of BclXL to Bak (IC50 =1.5uM) or Bad proteins and stimulates apoptosis in several cancer cell lines. Blocks human P2X7 receptor. Induces cell cycle arrest in G1 phase. Specific cyclooxygenase-2 inhibitor. Group: Biochemicals. Alternative Names: NSC 36405, 1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride. Grades: Highly Purified. CAS No. 3895-92-9. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C21H18ClNO4. US Biological Life Sciences. | Worldwide |
c-Jun Control Cell Extracts Quick inquiry Where to buy Suppliers range | C-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73 (1,2). Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. Mutation of Ser63/73 renders c-Jun nonresponsive to mitogenic and stress induced signaling pathways. The MAP kinase homologue, SAPK/JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. In addition, the activity of SAPK/JNK is stimulated by the same signals that activate c-Jun (3,4). Nonphosphorylated c-Jun (Ser63) II Cell Extracts: Total cell extracts from NIH/3T3 cells, prepared without treatment, serve as a negative control. Group: Biologicals. Grades: Lysate. Pack Sizes: 10Blots. US Biological Life Sciences. | Worldwide |
Ganciclovir Quick inquiry Where to buy Suppliers range | Ganciclovir (GCV) is a pro-drug nucleoside analog that is activated by phosphorylation. It is useful in the study of gene therapy in cancer research. Upon expression of a viral suicide gene encoding thymidine kinase, the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. The cell cycle is irreversibly arrested at the G2-M checkpoint. Gap junction involvement in the ganciclovir bystander effect has been studied. Ganciclovir has been used to study loss of telomeres and to evaluate sensitivity of viruses to antiviral treatments. Ganciclovir is used in molecular biology for selection against random recombination events when homologous recombination of a gene of interest is required. Group: Biochemicals. Alternative Names: 2-Amino-1, 9-dihydro-9-[[2-hydroxy-1- (hydroxymethyl) ethoxy]methyl]-6H-purin-6-one; 2-NDG; 2-Nor-2-deoxyguanosine; 9-(1,3-Dihydroxy-2-propoxymethyl)guanine; BW 759; BW 759U; BW-B 759U; Biolf 62; DHPG; Denosine; Gancyclovir; Ganguard; Ganquard; HHEMG; Hydroxyacyclovir; Natclovir; RS 21592; Vitrasert. Grades: Highly Purified. CAS No. 82410-32-0. Pack Sizes: 100mg, 500mg, 1g, 5g. Molecular Formula: C?H??N?O?, Molecular Weight: 255.23. US Biological Life Sciences. | Worldwide |
GDC-0941, Free Base, PI3K Inhibitor Quick inquiry Where to buy Suppliers range | GDC-0941 is a potent inhibitor of p110a and p110d (IC?? = 3nM). It selectively binds to PI3K isoforms in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway.GDC-0941 is a phosphatidylinositol 3-kinase (PI3K) inhibitor. Folkes, A.J., et al. "The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer." J. Med. Chem. 51: 5522-5532 (2008).GDC-0941 inhibited the growth of >70% of breast cancer cell lines tested, with EC50's <1 µM. GDC-0941 also demonstrated antitumor activity in preclinical models of breast cancer. Yao, E., et al. "Suppression of HER2/HER3-mediated growth of breast cancer cells with combinations of GDC-0941 PI3K inhibitor, trastuzumab, and pertuzumab." Clin. Cancer Res. 15: 4147-4156 (2009).The combination of GDC-0941 with trastuzumab is highly efficacious in the treatment of cancer cells in vitro and tumors in vivo. GDC-0941 also has antitumor activity in the treatment of trastuzumab-resistant cells and tumors. Junttila, T.T., et al. "Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941." Cancer Cell 15: 429-440 (2009).GDC-0941 inhibits the activity of recombinant PI3K in vitro with IC50's of 0.003 µM (P110α), 0.033 µM (P110 β), 0.003 µM (P110δ), 0.075 µM (P110γ), 0.58 µM (mTOR) and 1.23 µM (DNA-PK). GDC-0941 inhibited the growth of tumor cells in vitro with IC50's of 0.95 µM (U87MG), 0.07 µM (IGROV-1), 0.15 µM (DETROIT 562), 0.28 µM (PC3) and 0.54 µM (SKOV-3). GDC-0941 also inhibited the growth of U87 MG glioblastoma xenografts and IGROV-1 ovarian cancer xenografts in mice. Raynaud, F.I., et al. "Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941." Mol. Cancer Ther. 8: 1725-1738 (2009). Group: Biochemicals. Alternative Names: 2- (1H-indazol-4-yl) -6- ( (4- (methylsulfonyl) piperazin-1-yl) methyl) -4-morpholinothieno[3, 2-d]pyrimidine; 4-[2- (1H-Indazol-4-yl) -6-[[4- (methylsulfonyl) piperazin-1-yl]methyl]thieno[3, 2-d]pyrimidin-4-yl]morpholine; GDC 0941; GDC 941; GNE 0941; Pictilisib; Pictrelisib. Grades: Highly Purified. CAS No. 957054-30-7. Pack Sizes: 25mg, 50mg, 100mg. Molecular Formula: C??H??N?O?S?, Molecular Weight: 513.64. US Biological Life Sciences. | Worldwide |
IQ 1S Quick inquiry Where to buy Suppliers range | IQ 1S is a c-Jun N-terminal kinase (JNK) inhibitor. It inhibits the production of nitric oxide in vitro and inhibits the release of nitric oxide upon metabolism by liver microsomes. It attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity in vivo. It also inhibits the production of LPS-induced proinflammatory cytokine. It has anti-inflammatory and immunosuppressive effects. Synonyms: 11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt. Grades: ≥99% by HPLC. CAS No. 1421610-21-0. Molecular formula: C15H8N3NaO. Mole weight: 269.23. | |
IQ-1S free acid Quick inquiry Where to buy Suppliers range | IQ-1S free acid is a potent, selective c-Jun N-Terminal Kinase inhibitor with a preference for JNK3 (IC50=390, 360 and 87 nM for JNK1, 2 and 3 respectively). In vivo IQ-1S free acid exhibits immunosuppressant property and it inhibits murine delayed-type h. Synonyms: 11-nitroso-10H-indeno[1,2-b]quinoxaline IQ-1S (free acid) CHEMBL3393601 11-(hydroxyimino)indeno[2,3-b]quinoxaline 11-nitroso-10H-indeno[1,2-b]quinoxaline. CAS No. 23146-22-7. Molecular formula: C15H9N3O. Mole weight: 247.25. | |
IQ 3 Quick inquiry Where to buy Suppliers range | IQ 3 is a selective and specific c-Jun N-terminal kinase 3 (JNK3) inhibitor with Kd value of 66 nM. It inhibits TNF-α and IL-6 production in vitro and inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells. Synonyms: IQ3; IQ-3; IQ 3; 11H-Indeno[1,2-b]quinoxalin-11-one O-(2-furanylcarbonyl)oxime. Grades: ≥98% by HPLC. CAS No. 312538-03-7. Molecular formula: C20H11N3O3. Mole weight: 341.32. | |
JIP-1 (153-163) Quick inquiry Where to buy Suppliers range | Selective peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Uses: Peptide Inhibitors. CAS No. 438567-88-5. Product ID: R0970. | |
JIP-1 (153-163) Quick inquiry Where to buy Suppliers range | JIP-1 (153-163) has been found to be a peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Synonyms: TI-JIP. Grades: >98%. CAS No. 438567-88-5. Molecular formula: C61H104N20O14. Mole weight: 1341.6. | |
JIP-1 (153-163) acetate Quick inquiry Where to buy Suppliers range | JIP-1 (153-163) acetate is a c-Jun N-terminal kinase (JNK) peptide inhibitor based on JNK-interacting protein-1 (JIP-1) residues 153-163. It binds to JNK with affinity in the micromolar range and minimally inhibits p38 and ERK. Synonyms: L-Phenylalaninamide, L-arginyl-L-prolyl-L-lysyl-L-arginyl-L-prolyl-L-threonyl-L-threonyl-L-leucyl-L-asparaginyl-L-leucyl-, acetate (1:1); H-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH2.CH3CO2H; L-arginyl-L-prolyl-L-lysyl-L-arginyl-L-prolyl-L-threonyl-L-threonyl-L-leucyl-L-asparagyl-L-leucyl-L-phenylalaninamide acetate salt. Grades: ≥95%. CAS No. 1417623-78-9. Molecular formula: C61H104N20O14.C2H4O2. Mole weight: 1401.66. | |
JNK-IN-8 Quick inquiry Where to buy Suppliers range | JNK-IN-8 inhibits c-Jun phosphorylation in HeLa and A375 cells with EC50 of 486 nM and 338 nM, respectively. Uses: Protein kinase inhibitors. Synonyms: JNK-IN-8; JNK-IN 8; JNK-IN8; JNK Inhibitor XVI; c-Jun N-terminal Kinase Inhibitor XVI. Grades: >98%. CAS No. 1410880-22-6. Molecular formula: C29H29N7O2. Mole weight: 507.59. | |
JNK Inhibitor II (Anthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125, SAPK Inhibitor II) Quick inquiry Where to buy Suppliers range | A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50=40nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-y, TNF-a, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. Group: Biochemicals. Grades: Highly Purified. CAS No. 129-56-6. Pack Sizes: 5mg, 25mg, 50mg. Molecular Formula: C14H8N2O, Molecular Weight: 220.2. US Biological Life Sciences. | Worldwide |
JNK Inhibitor XVI, JNK-IN-8 ( (E) -3- (4- (dimethylamino) but-2-enamido) -N- (3-methyl-4- ( (4- (pyridin-3-yl) pyrimidin-2-yl) amino) phenyl) benzamide) Quick inquiry Where to buy Suppliers range | A cell-permeable, selective, and irreversible type 2 inhibitor of c-Jun N-terminal kinases (JNK) (IC50=4.67nM, 18.7nM, 980pM for JNK1, JNK2, and JNK3, respectively). Forms a covalent adduct with the conserved cysteine residue (Cys116 in JNK1) and binds to JNK in an extended type 2 conformation. Blocks the phosphorylation of c-Jun in cells (EC50=486nM in HeLa cells; 338nM in A375 cells). Exhibits greater cellular specificity for JNK when compared to 40 other kinases screened using a cell-based assay. Shows weaker binding to KIT mutants (IC50=92nM for V559D and 56nM for T670I) and RIOK2 (120nM). Does not show any significant inhibitory activity against various other kinases, including ERK, p38, Akt, MSK, and RSK. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Ochratoxin A Quick inquiry Where to buy Suppliers range | Ochratoxin A is a chlorinated benzopyran coupled to the amino acid phenylalanine, produced by several Aspergillus and Penicillium sp. associated with food spoilage. Ochratoxins are widely distributed in the environment and are known to be nephrotoxic, teratogenic and possibly carcinogenic. Ochratoxin A may act by induction of DNA strand breaks, sister chromatid exchanges, DNA adduct formation, or reactive oxygen but the mechanism of action as a toxin is not yet resolved. At the molecular level, ochratoxin A has been shown to specifically inhibit NK cell activity, increase growth of transplantable tumor cells in mice, increase apoptosis, activate c-Jun N terminal kinase in human kidney epithelial cells, and block metaphase/anaphase transition. It also inhibits plasminogen activator inhibitor-2 production by human blood mononuclear cells. Source:Aspergillus ochraceus MST-FP2005. Group: Biochemicals. Alternative Names: OTA; Ochratoxin A; Aspergillus ochraceus; N-[[(3R)-5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-phenylalanine; (-)-N-[(5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-3-phenylalanine; (R)-N-[(5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-benzo[c]pyran-7-yl)carbonyl]-3-phenylalanine; 3R,14S-Ochratoxin A; NSC 201422; NSC 221991; Phe-OTA; Phenylalanine-ochratoxin A. Grades: Highly Purified. CAS No. 303-47-9. Pack Sizes: 1mg. Molecular Formula: C??H??ClNO?, Molecular Weight: 403.8. US Biological Life Sciences. | Worldwide |
Okadaic acid ammonium salt (High Purity) (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) Quick inquiry Where to buy Suppliers range | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50= >1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Source:Isolated from Prorocentrum concavum. Salt form generated in aqueous ammonium hydroxide-methanol solution. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 155716-06-6. Pack Sizes: 25ug, 100ug. Molecular Formula: C44H67O13. NH4, Molecular Weight: 822. US Biological Life Sciences. | Worldwide |
Okadaic acid (High Purity) Quick inquiry Where to buy Suppliers range | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Source:Isolated from Prorocentrum concavum. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 78111-17-8. Pack Sizes: 25ug, 100ug. Molecular Formula: C44H68O13, Molecular Weight: 805. US Biological Life Sciences. | Worldwide |
Okadaic acid potassium salt (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) (High Purity) Quick inquiry Where to buy Suppliers range | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0.2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1uM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 155751-72-7. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
Okadaic acid sodium salt (high purity) (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) Quick inquiry Where to buy Suppliers range | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 209266-80-8. Pack Sizes: 25ug, 100ug. US Biological Life Sciences. | Worldwide |
p38 MAP Kinase Inhibitor XIX, Skepinone-L ((2-(2,4-Difluorophenylamino)-7-[2R-,3-dihydroxypropoxy]-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one)) Quick inquiry Where to buy Suppliers range | A cell-permeable phenylamino-dibenzosuberone-diol with a rigid molecular structure specifically designed to target hydrophobic region I in p38alpha & p38beta, but not in other kinases with bulky entrance-blocking gatekeeper residues. Shown to selectively inhibit p38alpha (IC50 = 5nM; [ATP] = 100uM) and p38beta (97% inhibition at 1uM), while exhibiting little affinity toward 400 other kinase constructs, including p38delta, p38upsilon, Erk1/2/3/4/5/8, JNK1/2/3, and MEK1/2/3/4/6. Shown to prevent cellular HSP27 Ser82 phosphorylation upon p38 activation by Anisomycin in HeLa (IC50 = 25nM) or by TNF-alpha in THP-1 cultures. Unlike the ATP-binding site-targeting BIRB 796 and SB 203580, Skepinone-L does not inhibit JNK-mediated c-Jun or ERK-dependent CREB phosphorylation in THP-1 cultures. Oral administration to D-Gal-sensitized mice is reported to greatly reduce plasma TNF-alpha production upon LPS challenge (by 77%; 3mg/kg p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Phorbol 12-myristate 13-acetate (PMA, TPA, 12-O-Tetradecanoylphorbol 13-acetate) Quick inquiry Where to buy Suppliers range | Most commonly-used phorbol ester. Binds to and activates protein kinase C (PKC) at nM concentrations. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors such as p21WAF1/CIP1, p27KIP1, p15 and p16. Potent mouse skin tumor promoter. Promoter of inducible NOS (iNOS; NOS II). Apoptosis inducer. Potential effective cancer therapeutic agent. Inhibitor of anti-lipolytic activity of insulin. Group: Biochemicals. Alternative Names: PMA; TPA; 12-O-Tetradecanoylphorbol 13-acetate. Grades: Highly Purified. CAS No. 16561-29-8. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C36H56O8, Molecular Weight: 616.83. US Biological Life Sciences. | Worldwide |
Sauchinone Quick inquiry Where to buy Suppliers range | Sauchinone, coming from the herbs of Saururus chinensis(Lour.) Baill, is a useful adjunctive treatment for bacterial infection. Sauchinone inhibited oxidative stress, as assessed by stainings of 4-hydroxynonenal and nitrotyrosine: these events may have a role in its inhibitory effects on HSCs activation. Sauchinone attenuated CCl4-induced liver fibrosis and TGF-β1-induced HSCs activation, which might be, at least in part, mediated by suppressing autophagy and oxidative stress in HSCs. Sauchinone protects skin keratinocytes through inhibition of extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 MAPK signaling via upregulation of oxidative defense enzymes. Uses: Anti-inflammatory/antibacterial. Synonyms: (5aR,7R,8S,8aR,14aS,14bR)-5a,6,7,8,8a,14b-Hexahydro-7,8-dimethyl-5H-Benzo[kl]bis[1,3]dioxolo[4,5-b:4',5'-g]xanthen-5-one; (5aα, 7α, 8β, 8aβ, 14aS*, 14bβ)-5a, 6, 7, 8, 8a, 14b-Hexahydro-7, 8-dimethyl-5H-benzo[kl]bis[1, 3]dioxolo[4, 5-b:4', 5'-g]xanthen-5-one. Grades: >98%. CAS No. 177931-17-8. Molecular formula: C20H20O6. Mole weight: 356.36. | |
SU 3327 Quick inquiry Where to buy Suppliers range | SU 3327 is a selective inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 0.7 μM) with selectivity over p38 MAPK and Akt. SU 3327 inhibits the interaction between JNK and JIP (IC50 = 239 nM). Synonyms: SU 3327; SU3327; SU-3327; 5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine. Grades: ≥99% by HPLC. CAS No. 40045-50-9. Molecular formula: C5H3N5O2S3. Mole weight: 261.3. | |
TCS JNK 6o Quick inquiry Where to buy Suppliers range | TCS JNK 6o is an ATP-competitive c-Jun N-terminal kinase (JNK) inhibitor with Kis of 2, 4 and 52 nM for JNK1, JNK2 and JNK3, respectively, and IC50s of 45 and 160 nM for JNK1 and JNK2, respectively. It shows >1000-fold selectivity over other kinases, including ERK2 and p38. It can inhibit apoptosis, caspase cleavage and cytochrome C release. Synonyms: JNK Inhibitor VIII; N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxybenzeneacetamide; Benzeneacetamide, N-(4-amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxy-. Grades: ≥98% by HPLC. CAS No. 894804-07-0. Molecular formula: C18H20N4O4. Mole weight: 356.38. | |
Verosudil Quick inquiry Where to buy Suppliers range | Verosudil is a selective Rho-kinase inhibitor originated by Aerie Pharmaceuticals. In Jun 2013, Phase-II for Ocular hypertension in USA was discontinued. In Sep 2013, Phase-II for Glaucoma in USA was discontinued. Uses: Glaucoma; ocular hypertension. Synonyms: AR 12286; AR12286; AR-12286; rac-(2R)-2-(dimethylamino)-N-(1-oxo- 1,2-dihydroisoquinolin-6-yl)-2-(thiophen-3-yl)acetamide. Grades: 98%. CAS No. 1414854-42-4. Molecular formula: C17H17N3O2S. Mole weight: 327.41. | |
XG 102 Quick inquiry Where to buy Suppliers range | XG-102 is a TAT-conjugated dextrose peptide that inhibits c-Jun N-terminal kinase, and has the potential to treat intraocular inflammation. Synonyms: AM 111; XG 102 peptide; D-JNKI-1. CAS No. 1198367-70-2. Molecular formula: C164H285N65O41. Mole weight: 3823.49. | |
XG 102 Quick inquiry Where to buy Suppliers range | XG-102, a TAT-coupled dextrogyre peptide inhibiting the c-Jun N-terminal kinase, was shown efficient in the treatment of experimental uveitis. Research show that XG-102 peptide has potential for treating intraocular inflammation. Uses: API. CAS No. 1198367-70-2. Product ID: 10-101-141. |