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| Product | Description | |
|---|---|---|
| minus-end-directed kinesin ATPase | Structurally almost identical to EC 3.6.4.3 (microtubule-severing ATPase) but the movement it catalyses is towards the minus end of microtubules. Group: Enzymes. Enzyme Commission Number: EC 3.6.4.5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4707; minus-end-directed kinesin ATPase; EC 3.6.4.5. Cat No: EXWM-4707. |  |
| plus-end-directed kinesin ATPase | Microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (α) chains (110 kDa) and two or more light (β) chains (65-75 kDa). Also hydrolyses GTP. Group: Enzymes. Synonyms: kinesin. Enzyme Commission Number: EC 3.6.4.4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4706; plus-end-directed kinesin ATPase; EC 3.6.4.4; kinesin. Cat No: EXWM-4706. | |
| 1,2,3,4-Tetrahydro-b-carboline (1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole, Noreleagnine, Tetrahydronorharman, THBC, Tryptoline) | A mitotic kinesin inhibitor as novel anti-cancer agent. Used in the study of neurodegenerative diseases. Group: Biochemicals. Alternative Names: 1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole, Noreleagnine, Tetrahydronorharman, THBC, Tryptoline. Grades: Highly Purified. CAS No. 16502-01-5. Pack Sizes: 1g, 5g, 10g. US Biological Life Sciences. |  Worldwide |
| 2,2-Difluoroethyl Triflate | 2,2-Difluoroethyl Triflate is used to prepare kinesin spindle protein inhibitors for treatment of taxane-refractory cancer. It is also used to synthesize MexAB-?OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Group: Biochemicals. Grades: Highly Purified. CAS No. 74427-22-8. Pack Sizes: 1g, 5g. Molecular Formula: C3H3F5O3S, Molecular Weight: 214.11. US Biological Life Sciences. | Worldwide |
| 2-(4-Hydroxyphenoxy)acetic Acid | 2-(4-Hydroxyphenoxy)acetic Acid is used in the design, synthesis and evaluation of postulated transient intermediate and substrate analogues as inhibitors of 4-hyroxyphenylpyruvate dioxygenase. Acts as a reagent in the preparation, anti-HIV and kinesin Eg5 inhibitory activities, QSAR, and modeling studies of triazolothiadiazole and triazolothiadiazine derivatives. Synthesis of thiadiazolotriazin-4-ones and study of their mosquito-larvicidal and antibacterial properties. Group: Biochemicals. Grades: Highly Purified. CAS No. 1878-84-8. Pack Sizes: 250mg, 1g. Molecular Formula: C8H8O4, Molecular Weight: 168.15. US Biological Life Sciences. | Worldwide |
| 2'-Deoxycytidine | A deoxyribonucleoside as Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity. Synonyms: deoxycytidine; dCYD. Grades: ≥ 98 % by HPLC. CAS No. 951-77-9. Molecular formula: C9H13N3O4. Mole weight: 227.22. |  |
| 2'-Deoxy Cytidine-2',2'-d2 | 2'-Deoxy Cytidine-2',2'-d2 is the deuterated version of 2-Deoxy Cytidine (D232615),which is a deoxyribonucleoside as Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 114218-03-0. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C9H11D2N3O4, Molecular Weight: 229.23. US Biological Life Sciences. | Worldwide |
| 2'-Deoxycytidine 3'-Monophosphate 5'-Triphosphate Triethylamine Salt | 2'-Deoxycytidine 3'-Monophosphate 5'-Triphosphate is a derivative of 2'-Deoxy Cytidine which is A deoxyribonucleoside as Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity. Synonyms: 2'-Deoxycytidine 5'-Triphosphate 3'-Phosphate Triethylamine Salt. Molecular formula: C9H17N3O16P4 xC6H15N. Mole weight: 547.14. | |
| 2-Deoxycytidine 3'-Monophosphate 5'-Triphosphate Triethylamine Salt | 2-Deoxycytidine 3'-Monophosphate 5'-Triphosphate is a derivative of 2-Deoxy Cytidine (D232615) which is A deoxyribonucleoside as Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C9H17N3O16P4 xC6H15N, Molecular Weight: 547.141011899999. US Biological Life Sciences. | Worldwide |
| 2'-Deoxy Cytidine-5-d1 | 2'-Deoxy Cytidine-5-d1 is the deuterated version of 2-Deoxy Cytidine (D232615),which is a deoxyribonucleoside as Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 25352-61-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C9H12DN3O4, Molecular Weight: 228.22. US Biological Life Sciences. | Worldwide |
| (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide Hydrochloride | (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide Hydrochloride is a known potent kinesin spindle protein inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1385020-40-5. Pack Sizes: 10mg, 25mg. Molecular Formula: C20H22F2N4O2S; (HCl). US Biological Life Sciences. | Worldwide |
| 3-Butyn-1-amine | 3-Butyn-1-amine is a reagent used to prepare alkylaminodiaryl -dihydropyrazoles as potent, water-soluble inhibitors of mitotic kinesin spindle protein inhibitors. It is also used to synthesize oxoquinoline derivatives as cannabinoid CB2 receptor ligands. Group: Biochemicals. Grades: Highly Purified. CAS No. 14044-63-4. Pack Sizes: 100mg, 1 g. Molecular Formula: C4H7N, Molecular Weight: 69.11. US Biological Life Sciences. | Worldwide |
| 5-Chloro-2-nitroanisole | 5-Chloro-2-nitroanisole is involved in the synthesis of orally bioavailable anaplastic lymphoma kinases (ALK) inhibitors as anticancer drugs. In addition it is used in the synthesis of kinesin spindle protein (KSP) inhibitors which are responsible for the spindle pole separation which occurs during mitosis in cancer cells. Group: Biochemicals. Alternative Names: 4-Chloro-2-methoxy-1-nitrobenzene; 5-Chloro-2-nitroanisole; 1-Chloro-3-methoxy-4-nitrobenzene; 2-Methoxy-4-chloronitrobenzene; 2-Nitro-5-chloroanisole; 3-Methoxy-4-nitro-1-chlorobenzene; 4-Chloro-2-(methyloxy)-1-nitrobenzene; 4-Chloro-2-methoxy-1-nitrobenzene; 4-Chloro-2-methoxynitrobenzene; 5-Chloro-2-nitroanisole; 5-Chloro-2-nitrophenyl Methyl Ether; NSC 60112. Grades: Highly Purified. CAS No. 6627-53-8. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| ARRY-520 R enantiomer | ARRY-520 R enantiomer is the R form of ARRY-520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor. ARRY-520 had low nanomolar antiproliferative activity in tumor cell lines and specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Synonyms: ARRY-520 R enantiomer; ARRY 520 R enantiomer; ARRY520 R enantiomer; 1,3,4-Thiadiazole-3(2H)-carboxamide, 2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-, (2R)-. Grades: >98%. CAS No. 885060-08-2. Molecular formula: C20H22F2N4O2S. Mole weight: 420.48. | |
| AZ 3146 | AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit. Synonyms: AZ3146; AZ 3146; AZ-3146. Grades: >98%. CAS No. 1124329-14-1. Molecular formula: C24H32N6O3. Mole weight: 452.55. | |
| AZ82 | AZ82 is a kinesin-14 family protein that is important for assembling bipolar spindles in cancer cells containing supernumerary centrosomes. AZ82 is a selective kinesin-like protein HSET inhibitor with Ki of 43 nM and KIFC1 inhibitor with IC50 of 300 nM. It shows microtubule-noncompetitive manner but does not inhibit basal KIFC1 activity at a concentration of 100 μM. In Vitro, AZ82 is shown to specifically induce multipolar spindles in BT-549 cells, but not in cancer cells with normal centrosome number, such as HeLa. Synonyms: AZ-82; AZ 82. Grades: ≥98%. CAS No. 1449578-65-7. Molecular formula: C28H31F3N4O3S. Mole weight: 560.6. | |
| AZD4877 | AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may result in the inhibition of mitotic spindle assembly. Synonyms: AZD-4877; AZD 4877; (+)-N-(3-Aminopropyl)-N-(1-(5-benzyl-3-methyl-4-oxo-(1,2)thiazolo(5,4-d)pyrimidin-6-yl)-2-methylpropyl)-4-methylbenzamide. CAS No. 1176760-49-8. Molecular formula: C28H33N5O2S. Mole weight: 503.66. | |
| BRD 9876 | BRD 9876 is an ATP non-competitive kinesin Eg5 inhibitor. It selectively inhibits microtubule-bound Eg5 leading to an arrest in G2/M phase. Synonyms: BRD9876; BRD-9876; BRD 9876; 6-(1,1-Dimethylethyl)-2,3-naphthalenedicarbonitrile; 6-Tert-Butyl-2,3-naphthalenedicarbonitrile. Grades: ≥99% by HPLC. CAS No. 32703-82-5. Molecular formula: C16H14N2. Mole weight: 234.3. | |
| BTB-1 | BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A, which was identified by Catarinella et al. during a highthroughput screen against Kif18A's MT-stimulated ATPase activity, with an IC50 of 1.7-1.9 M. It is selective within the kinesin subgroup of Kif4, Eg5, MKLP-1, MKLP-2, MPP1, CENP-E and MCAK, and during in vitro motility assays Kif18A's MT gliding ability was blocked by the addition of BTB-1 in a reversible manner. BTB-1 was found to be ATP competitive and MT uncompetitive, only inhibiting the ATPase activity of the MT-bound motor protein. BTB-1 could serve as a valuable tool in disentangling the nature of Kif18A's double functionality within mitosis and assessing for potential therapeutic utilities. Synonyms: BTB 1; BTB1; 4-Chloro-2-nitro-1-(phenylsulfonyl)benzene; 4-Chloro-2-nitrodiphenyl sulfone; NSC 156750. CAS No. 86030-08-2. Molecular formula: C12H8ClNO4S. Mole weight: 297.71. | |
| Dimethylenastron | Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 (IC50 = 200 nM).The inhibition of kinesin Eg5 by small molecules such as monastrol is currently evaluated as an approach to develop a novel class of antiproliferative drugs for the treatment of malignant tumours. Synonyms: Dimethylenastron. Grades: 98%. CAS No. 863774-58-7. Molecular formula: C16H18N2O2S. Mole weight: 302.39. | |
| Eg5-I | Eg5, also known as KSP and Kif11, is a kinesin-like spindle protein that is essential for establishing a bipolar spindle during mitosis. Eg5-I is a potent inhibitor of Eg5, both in vitro and in cells (IC50s = 127 and 190 nM, respectively). Synonyms: (2R)-2-amino-3-[[(4-methoxyphenyl)diphenylmethyl]thio]-1-propanol. Grades: ≥98%. CAS No. 1338701-15-7. Molecular formula: C23H25NO2S. Mole weight: 379.5. | |
| EMD534085 | EMD534085 is a potent and selective mitotic kinesin-5 inhibitor with an IC50 of 8 nM. Synonyms: 1-(2-(Dimethylamino)ethyl)-3-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano(3,2-C)quinolin-2-yl)methyl)urea; EMD-534085; EMD 534085; N-[2-(Dimethylamino)ethyl]-N'-[[(2R,4aS,5R,10bS)-3,4,4a,5,6,10b-hexahydro-5-phenyl-9-(trifluoromethyl)-2H-pyrano[3,2-c]quinolin-2-yl]methyl]urea. Grades: ≥95%. CAS No. 858668-07-2. Molecular formula: C25H31F3N4O2. Mole weight: 476.53. | |
| Filanesib | Filanesib, also known as ARRY-520, is a synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Synonyms: ARRY-520; ARRY 520; ARRY520. Grades: 0.98. CAS No. 885060-09-3. Molecular formula: C20H22F2N4O2S. Mole weight: 420.479. | |
| Filanesib | Filanesib (ARRY-520) is a selective and noncompetitive kinesin spindle protein ( KSP ) inhibitor, with an IC 50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARRY-520. CAS No. 885060-09-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15187. |  |
| Filanesib | Filanesib / ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Group: Fluorinated apis. Alternative Names: ARRY-520. CAS No. 885060-09-3. Molecular formula: C20H22F2N4O2S. Mole weight: 420.48. Appearance: White solid powder. Purity: >95%. IUPACName: (2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide. Catalog: OFC885060093. |  |
| Ispinesib | Ispinesib is a specific inhibitor of kinesin spindle protein (KSP) , with a K i app of 1.7 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-715992. CAS No. 336113-53-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50759. | |
| Ispinesib | Ispinesib is a synthetic small molecule, derived from quinazolinone, with antineoplastic properties. Ispinesib selectively inhibits the mitotic motor protein, kinesin spindle protein (KSP), resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and cell death in tumor cells that are actively dividing. Because KSP is not involved in nonmitotic processes, such as neuronal transport, ispinesib may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents. Synonyms: SB-715992; SB715992; SB 715992; CK 0238273; CK-0238273; CK0238273. CAS No. 336113-53-2. Molecular formula: C30H33ClN4O2. Mole weight: 517.07. | |
| K-858 | K-858 is a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. K858 blocked centrosome separation, activated the spindle checkpoint, and induced mitotic arrest in cells accompanied by the formation of monopolar spindles. Synonyms: K-858; K 858; K858. Grades: 98%. CAS No. 72926-24-0. Molecular formula: C13H15N3O2S. Mole weight: 277.34. | |
| Kif15-IN-1 | Kif15-IN-1 is a potent Kif15 kinesin inhibitor, which inhibits cellular proliferation in tumor cell lines. Synonyms: KIF15-IN-1; KIF15IN-1; KIF15-IN1; KIF15IN1; KIF15 IN 1. Grades: >98%. CAS No. 672926-32-8. Molecular formula: C20H22N4O5S. Mole weight: 430.48. | |
| Kif15-IN-2 | Kif15-IN-2 is a potent Kif15 kinesin inhibitor, which inhibits cellular proliferation in tumor cell lines. Synonyms: KIF15-IN-2; KIF15IN-2; KIF15-IN2; KIF15IN2; KIF15 IN 2. Grades: >98%. CAS No. 672926-33-9. Molecular formula: C20H20N6O4S. Mole weight: 440.48. | |
| Kinesore | Kinesore is a cell-permeable kinesin-1 modulator. It inhibits kinesin-1 interactions with short linear peptide motifs found in organelle-specific cargo adaptors, but activates kinesin-1's function of controlling microtubule dynamics in cells. Synonyms: 3,5-Dibromo-N'-((2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl)methylene)-4-hydroxybenzohydrazide. Grades: ≥98% by HPLC. CAS No. 363571-83-9. Molecular formula: C20H16Br2N4O4. Mole weight: 536.17. | |
| Litronesib | litronesib, also known as LY2523355, is an inhibitor of the kinesin-related motor protein Eg5 with potential antineoplastic activity. Litronesib selectively inhibits the activity of Eg5, which may result in mitotic disruption, apoptosis and consequently cell death in tumor cells that are actively dividing. The ATP-dependent Eg5 kinesin-related motor protein (also known as KIF11 or kinesin spindle protein-5) is a plus-end directed kinesin motor protein that plays an essential role during mitosis, particularly in the regulation of spindle dynamics, including assembly and maintenance. Synonyms: litronesib; LY2523355; KF89617; LY 2523355; KF 89617; LY-2523355; KF-89617. CAS No. 910634-41-2. Molecular formula: C23H37N5O4S2. Mole weight: 511.7. | |
| Methyl Triphenylmethyl Ether | A trityl-cysteine analog as inhibitor of human mitotic kinesin. Group: Biochemicals. Alternative Names: 1, 1', 1''- (Methoxymethylidyne) trisbenzene. Grades: Highly Purified. CAS No. 596-31-6. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| MK-0731 | MK-0731 is a synthetic small molecule with potential antineoplastic activity. MK0731 selectively inhibits kinesin spindle protein (KSP), which may result in the inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and apoptosis in tumor cells that overexpress KSP. Uses: Potential antineoplastic agent. Synonyms: ALR-3456; ALR 3456; ALR3456; 845256-65-7; MK0731, MK-0731, MK 0731; UNII-8HIJ5G3O02; 8HIJ5G3O02. CAS No. 845256-65-7. Molecular formula: C25H28F3N3O2. Mole weight: 459.513. | |
| Monastrol | Monastrol is a kinesin Eg5 inhibitor. Induction of apoptosis by monastrol is independent of the spindle checkpoint. Monastrol binds to the KSP-ADP complex, forming a KSP-ADP-monastrol ternary complex, which cannot bind to microtubules productively and cannot undergo further ATP-driven conformational changes. Uses: Antimitotic agents. Synonyms: DL-Monastrol; (S)-Monastrol; (+/-)-Monastrol; 4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester. CAS No. 254753-54-3. Molecular formula: C14H16N2O3S. Mole weight: 292.36. | |
| Monastrol (6-Methyl-4-(3-hydroxyphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate) | A cell-permeablesmall molecule inhibitor of the mitotic kinesin, Eg5, arrests cells in mitosis with monoastral spindles. Group: Biochemicals. Alternative Names: 6-Methyl-4-(3-hydroxyphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Paprotrain | Cell permeable kinesin-specific MKLP-2 (mitotic kinesin-like protein 2) inhibitor. Inhibits the recruitment of the chromosome passenger proteins survivin and aurora B to the central spindle during anaphase chromosome segregation. Group: Biochemicals. Grades: Highly Purified. CAS No. 57046-73-8. Pack Sizes: 1mg. Molecular Formula: C16H11N3. US Biological Life Sciences. | Worldwide |
| Paprotrain | Paprotrain is a reversible, non-ATP competitive inhibitor of the kinesin MKLP-2 with selectivity over 12 other members of the kinesin superfamily, including the closely-related MKLP-1. Paprotrain shows a moderate inhibition activity on DYRK1A (IC50 = 5.5 μM). Synonyms: (Z)-2-(1H-indol-3-yl)-3-pyridin-3-ylprop-2-enenitrile; 2-(1H-indol-3-yl)-3-(pyridin-3-yl)acrylonitrile. CAS No. 57046-73-8. Molecular formula: C16H11N3. Mole weight: 245.28. | |
| proteasome ATPase | Belongs to the AAA-type superfamily and, like EC 3.6.4.5 (minus-end-directed kinesin ATPase), is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome. Group: Enzymes. Enzyme Commission Number: EC 3.6.4.8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4710; proteasome ATPase; EC 3.6.4.8. Cat No: EXWM-4710. | |
| SB-743921 HCl | SB-743921 is a synthetic small molecule with potential antineoplastic properties. SB-743921 selectively inhibits kinesin spindle protein (KSP), an important protein involved in the early stages of mitosis that is expressed in proliferating cells. Inhibition of KSP results in inhibition of mitotic spindle assembly and interrupts cell division, thereby causing cell cycle arrest and induction of apoptosis. Synonyms: SB-743921; SB 743921; SB743921. Grades: >98%. CAS No. 940929-33-9. Molecular formula: C31H34Cl2N2O3. Mole weight: 553.524. | |
| SB-743921 hydrochloride | SB-743921 hydrochloride is a potent inhibitor of the mitotic kinesin KSP (Eg5) , with a K i of 0.1 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 940929-33-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12069. | |
| Sovilnesib | Sovilnesibum is a kinesin-like protein KIF18A inhibitor and antineoplastic. Synonyms: Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[2-(4,4-difluoro-1-piperidinyl)-6-methyl-4-pyrimidinyl]-4-[[(2-hydroxyethyl)sulfonyl]amino]-. Grades: >98%. CAS No. 2410796-79-9. Molecular formula: C26H34F2N6O4S. Mole weight: 564.65. | |
| S-Trityl-L-cysteine | S-Trityl-L-cysteine is a cell-permeable, potent and selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. S-Trityl-L-cysteine inhibits basal and microtubule-activated ATPase activity of Eg5 (IC50 = 1 mM and 140 nM, respectively). S-Trityl-L-cysteine was shown to induce mitotic arrest in HeLa cells with an IC50 of 700 nM. Synonyms: S-(Triphenylmethyl)-L-cysteine. Grades: ≥ 98% (HPLC). CAS No. 2799-7-7. Molecular formula: C22H21NO2S. Mole weight: 363.47. | |
| Syntelin | Syntelin is a selectively CENP-E inhibitor. Syntelin inhibited CENP-E motility in a dose-dependent manner with an IC50 value of 160 nM. Among an extensive list of mitotic kinesins examined, syntelin was found to be highly selective for CENP-E. Syntelin binds to different sites from those of GSK923295, a recently identified CENP-E ATPase inhibitor, as syntelin inhibits CENP-E mutants resistant to GSK923295 in a manner indistinguishable from that of wild type motor. Syntelin represents a novel class of CENP-E motor inhibitor. Synonyms: [(5-{[(4-amino-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-yl)thio]methyl}-4-phenyl-4H-1,2,4-triazol-3-yl)thio]acetic acid. Grades: 98%. CAS No. 438481-33-5. Molecular formula: C21H20N6O2S3. Mole weight: 484.61. | |
| Terpendole E (1'alpha-Hydroxy-Paspaline) | Inhibitor to Acyl-CoA: Cholesterol acyltransferase (ACAT), Mitotic kinesin Eg5 (Mitotic Kinesin Spindle Protein; KSP) and Specific M phase. Group: Biochemicals. Alternative Names: 1'alpha-Hydroxy-Paspaline. Grades: Highly Purified. CAS No. 167427-23-8. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| Triphenylmethylamine | Triphenylmethylamine is a trityl derivative that is structurally related to Clotrimazole. Triphenylmethylamine is used in the preparation of trityl-cysteine analogs as inhibitors of human mitotic kinesin. Triphenylmethylamine is also used as a fireproofing agent. Group: Biochemicals. Alternative Names: α , α -Diphenyl Benzene methanamine; Tritylamine; Aminotriphenylmethane; NSC 1154; Triphenylmethanamine. Grades: Highly Purified. CAS No. 5824-40-8. Pack Sizes: 25g. US Biological Life Sciences. | Worldwide |
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