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| Product | Description | |
|---|---|---|
| Kinesin family member 27, isoform CRAb (84-103) | A peptide fragment of Kinesin family member 27, isoform CRAb. KIF27 plays an essential role in motile ciliogenesis. Synonyms: Kinesin-Like Protein KIF27 isoform CRA_b (84-103). |  |
| Kinesin-like protein KIF20A (12-20) | Kinesin-like protein KIF20A (12-20) is a 9-aa peptide. Kinesin-like protein KIF20A is a mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Synonyms: Mitotic kinesin-like protein 2 (12-20); Rab6-interacting kinesin-like protein (12-20). | |
| Kinesin-like protein KIF20A (284-293) | Kinesin-like protein KIF20A (284-293) is a 10-aa peptide. Kinesin-like protein KIF20A is a mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Synonyms: Mitotic kinesin-like protein 2 (284-293); Rab6-interacting kinesin-like protein (284-293). | |
| Kinesin-like protein KIF20A (809-817) | Kinesin-like protein KIF20A (809-817) is a 9-aa peptide. Kinesin-like protein KIF20A is a mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Synonyms: Mitotic kinesin-like protein 2 (809-817); Rab6-interacting kinesin-like protein (809-817). | |
| Anti-phospho-Kinesin-like Protein KIF1C (pSer1092) antibody produced in rabbit | affinity isolated antibody. Group: Fluorescence/luminescence spectroscopy. |  |
| minus-end-directed kinesin ATPase | Structurally almost identical to EC 3.6.4.3 (microtubule-severing ATPase) but the movement it catalyses is towards the minus end of microtubules. Group: Enzymes. Enzyme Commission Number: EC 3.6.4.5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4707; minus-end-directed kinesin ATPase; EC 3.6.4.5. Cat No: EXWM-4707. |  |
| plus-end-directed kinesin ATPase | Microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (α) chains (110 kDa) and two or more light (β) chains (65-75 kDa). Also hydrolyses GTP. Group: Enzymes. Synonyms: kinesin. Enzyme Commission Number: EC 3.6.4.4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4706; plus-end-directed kinesin ATPase; EC 3.6.4.4; kinesin. Cat No: EXWM-4706. | |
| 1,2,3,4-Tetrahydro-b-carboline (1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole, Noreleagnine, Tetrahydronorharman, THBC, Tryptoline) | A mitotic kinesin inhibitor as novel anti-cancer agent. Used in the study of neurodegenerative diseases. Group: Biochemicals. Alternative Names: 1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole, Noreleagnine, Tetrahydronorharman, THBC, Tryptoline. Grades: Highly Purified. CAS No. 16502-01-5. Pack Sizes: 1g, 5g, 10g. US Biological Life Sciences. |  Worldwide |
| 2,2-Difluoroethyl Triflate | 2,2-Difluoroethyl Triflate is used to prepare kinesin spindle protein inhibitors for treatment of taxane-refractory cancer. It is also used to synthesize MexAB-?OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Group: Biochemicals. Grades: Highly Purified. CAS No. 74427-22-8. Pack Sizes: 1g, 5g. Molecular Formula: C3H3F5O3S, Molecular Weight: 214.11. US Biological Life Sciences. | Worldwide |
| 2-(4-Hydroxyphenoxy)acetic Acid | 2-(4-Hydroxyphenoxy)acetic Acid is used in the design, synthesis and evaluation of postulated transient intermediate and substrate analogues as inhibitors of 4-hyroxyphenylpyruvate dioxygenase. Acts as a reagent in the preparation, anti-HIV and kinesin Eg5 inhibitory activities, QSAR, and modeling studies of triazolothiadiazole and triazolothiadiazine derivatives. Synthesis of thiadiazolotriazin-4-ones and study of their mosquito-larvicidal and antibacterial properties. Group: Biochemicals. Grades: Highly Purified. CAS No. 1878-84-8. Pack Sizes: 250mg, 1g. Molecular Formula: C8H8O4, Molecular Weight: 168.15. US Biological Life Sciences. | Worldwide |
| 2'-Deoxycytidine | A deoxyribonucleoside as Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity. Synonyms: deoxycytidine; dCYD. Grade: ≥ 98 % by HPLC. CAS No. 951-77-9. Molecular formula: C9H13N3O4. Mole weight: 227.22. | |
| 2'-Deoxycytidine-[2'-13C] Monohydrate | 2-Deoxycytidine-[2-13C] Hydrate is the labelled Hydrate of 2-Deoxycytidine, which is a deoxyribonucleoside as an Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity. Synonyms: 2-Deoxycytidine H2O (deoxyribose-2-13C); 2'-Deoxycytidine-13C Hydrate; 2'-Deoxycytidine-2'-13C Monohydrate; [2'-13C]2'-deoxycytidine 1-hydrate; 1-(2-Deoxy-β-D-ribofuranosyl)cytosine-13C Hydrate; 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone-13C Hydrate; Cytosine Deoxyribonucleoside-13C Hydrate. Grade: ≥90%; ≥99% atom 13C. CAS No. 478511-23-8. Molecular formula: C8[13C]H15N3O5. Mole weight: 246.23. | |
| 2'-Deoxy Cytidine-[2',2'-d2] | 2'-Deoxy Cytidine-[2',2'-d2] is the labelled analogue of 2'-Deoxy Cytidine, which is a deoxyribonucleoside used as an Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity. Synonyms: 2'-Deoxy Cytidine-2',2'-d2; 1-(2-Deoxy-β-D-ribofuranosyl)cytosine-d2; 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone-d2; Cytosine Deoxyribonucleoside-d2; Cytosine Deoxyriboside-d2; Deoxycytidine-d2; Deoxyribose Cytidine-d2. CAS No. 114218-03-0. Molecular formula: C9H11D2N3O4. Mole weight: 229.23. | |
| 2'-Deoxy Cytidine-2',2'-d2 | 2'-Deoxy Cytidine-2',2'-d2 is the deuterated version of 2-Deoxy Cytidine (D232615),which is a deoxyribonucleoside as Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 114218-03-0. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C9H11D2N3O4, Molecular Weight: 229.23. US Biological Life Sciences. | Worldwide |
| 2'-Deoxycytidine 3'-Monophosphate 5'-Triphosphate Triethylamine Salt | 2'-Deoxycytidine 3'-Monophosphate 5'-Triphosphate is a derivative of 2'-Deoxy Cytidine which is A deoxyribonucleoside as Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity. Synonyms: 2'-Deoxycytidine 5'-Triphosphate 3'-Phosphate Triethylamine Salt. Molecular formula: C9H17N3O16P4 xC6H15N. Mole weight: 547.14. | |
| 2-Deoxycytidine 3'-Monophosphate 5'-Triphosphate Triethylamine Salt | 2-Deoxycytidine 3'-Monophosphate 5'-Triphosphate is a derivative of 2-Deoxy Cytidine (D232615) which is A deoxyribonucleoside as Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C9H17N3O16P4 xC6H15N, Molecular Weight: 547.141011899999. US Biological Life Sciences. | Worldwide |
| 2'-Deoxy Cytidine-[5,6-d2] | 2'-Deoxy Cytidine-[5,6-d2] is the labelled analogue of 2'-Deoxy Cytidine, which is a deoxyribonucleoside used as an Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity. Synonyms: 2'-Deoxy Cytidine-5,6-d2; 1-(2-Deoxy-β-D-ribofuranosyl)cytosine-d2; 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone-d2; Cytosine Deoxyribonucleoside-d2; Cytosine Deoxyriboside-d2; Deoxycytidine-d2; Deoxyribose Cytidine-d2. Grade: ≥90%. CAS No. 1186526-91-9. Molecular formula: C9H11D2N3O4. Mole weight: 229.23. | |
| 2'-Deoxy Cytidine-[5-d] | 2'-Deoxy Cytidine-[5-d] is the labelled analogue of 2'-Deoxy Cytidine, which is a deoxyribonucleoside used as an Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity. Synonyms: 2'-Deoxy Cytidine-5-d1; 1-(2-Deoxy-β-D-ribofuranosyl)cytosine-d1; 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone-d1; Cytosine Deoxyribonucleoside-d1; Cytosine Deoxyriboside-d1; Deoxycytidine-d1; Deoxyribose Cytidine-d1. CAS No. 25352-61-8. Molecular formula: C9H12DN3O4. Mole weight: 228.22. | |
| 2'-Deoxy Cytidine-5-d1 | 2'-Deoxy Cytidine-5-d1 is the deuterated version of 2-Deoxy Cytidine (D232615),which is a deoxyribonucleoside as Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 25352-61-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C9H12DN3O4, Molecular Weight: 228.22. US Biological Life Sciences. | Worldwide |
| (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide Hydrochloride | (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide Hydrochloride is a known potent kinesin spindle protein inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1385020-40-5. Pack Sizes: 10mg, 25mg. Molecular Formula: C20H22F2N4O2S; (HCl). US Biological Life Sciences. | Worldwide |
| 3-Butyn-1-amine | 3-Butyn-1-amine is a reagent used to prepare alkylaminodiaryl -dihydropyrazoles as potent, water-soluble inhibitors of mitotic kinesin spindle protein inhibitors. It is also used to synthesize oxoquinoline derivatives as cannabinoid CB2 receptor ligands. Group: Biochemicals. Grades: Highly Purified. CAS No. 14044-63-4. Pack Sizes: 100mg, 1 g. Molecular Formula: C4H7N, Molecular Weight: 69.11. US Biological Life Sciences. | Worldwide |
| 5-Chloro-2-nitroanisole | 5-Chloro-2-nitroanisole is involved in the synthesis of orally bioavailable anaplastic lymphoma kinases (ALK) inhibitors as anticancer drugs. In addition it is used in the synthesis of kinesin spindle protein (KSP) inhibitors which are responsible for the spindle pole separation which occurs during mitosis in cancer cells. Group: Biochemicals. Alternative Names: 4-Chloro-2-methoxy-1-nitrobenzene; 5-Chloro-2-nitroanisole; 1-Chloro-3-methoxy-4-nitrobenzene; 2-Methoxy-4-chloronitrobenzene; 2-Nitro-5-chloroanisole; 3-Methoxy-4-nitro-1-chlorobenzene; 4-Chloro-2-(methyloxy)-1-nitrobenzene; 4-Chloro-2-methoxy-1-nitrobenzene; 4-Chloro-2-methoxynitrobenzene; 5-Chloro-2-nitroanisole; 5-Chloro-2-nitrophenyl Methyl Ether; NSC 60112. Grades: Highly Purified. CAS No. 6627-53-8. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| ARRY 520 hydrochloride | ARRY 520 hydrochloride is a kinesin spindle protein (Ksp) inhibitor with potential antineoplastic activity. Synonyms: Filanesib hydrochloride; (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide Hydrochloride; 1,3,4-Thiadiazole-3(2H)-carboxamide, 2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-, hydrochloride (1:1), (2S)-; ARRY-520 hydrochloride. Grade: 95%. CAS No. 1385020-40-5. Molecular formula: C20H23ClF2N4O2S. Mole weight: 456.94. | |
| ARRY-520 R enantiomer | ARRY-520 R enantiomer is the R form of ARRY-520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor. ARRY-520 had low nanomolar antiproliferative activity in tumor cell lines and specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Synonyms: ARRY-520 R enantiomer; ARRY 520 R enantiomer; ARRY520 R enantiomer; 1,3,4-Thiadiazole-3(2H)-carboxamide, 2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-, (2R)-. Grade: >98%. CAS No. 885060-08-2. Molecular formula: C20H22F2N4O2S. Mole weight: 420.48. | |
| AZ 3146 | AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit. Synonyms: AZ3146; AZ 3146; AZ-3146. Grade: >98%. CAS No. 1124329-14-1. Molecular formula: C24H32N6O3. Mole weight: 452.55. | |
| AZ82 | AZ82 is a kinesin-14 family protein that is important for assembling bipolar spindles in cancer cells containing supernumerary centrosomes. AZ82 is a selective kinesin-like protein HSET inhibitor with Ki of 43 nM and KIFC1 inhibitor with IC50 of 300 nM. It shows microtubule-noncompetitive manner but does not inhibit basal KIFC1 activity at a concentration of 100 μM. In Vitro, AZ82 is shown to specifically induce multipolar spindles in BT-549 cells, but not in cancer cells with normal centrosome number, such as HeLa. Synonyms: AZ-82; AZ 82. Grade: ≥98%. CAS No. 1449578-65-7. Molecular formula: C28H31F3N4O3S. Mole weight: 560.6. | |
| AZ82 | AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1. Uses: Scientific research. Group: Signaling pathways. CAS No. 1449578-65-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12241. |  |
| AZD4877 | AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may result in the inhibition of mitotic spindle assembly. Synonyms: AZD-4877; AZD 4877; (+)-N-(3-Aminopropyl)-N-(1-(5-benzyl-3-methyl-4-oxo-(1,2)thiazolo(5,4-d)pyrimidin-6-yl)-2-methylpropyl)-4-methylbenzamide. CAS No. 1176760-49-8. Molecular formula: C28H33N5O2S. Mole weight: 503.66. | |
| BRD 9876 | BRD 9876 is an ATP non-competitive kinesin Eg5 inhibitor. It selectively inhibits microtubule-bound Eg5 leading to an arrest in G2/M phase. Synonyms: BRD9876; BRD-9876; BRD 9876; 6-(1,1-Dimethylethyl)-2,3-naphthalenedicarbonitrile; 6-Tert-Butyl-2,3-naphthalenedicarbonitrile. Grade: ≥99% by HPLC. CAS No. 32703-82-5. Molecular formula: C16H14N2. Mole weight: 234.3. | |
| BTB-1 | BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A, which was identified by Catarinella et al. during a highthroughput screen against Kif18A's MT-stimulated ATPase activity, with an IC50 of 1.7-1.9 M. It is selective within the kinesin subgroup of Kif4, Eg5, MKLP-1, MKLP-2, MPP1, CENP-E and MCAK, and during in vitro motility assays Kif18A's MT gliding ability was blocked by the addition of BTB-1 in a reversible manner. BTB-1 was found to be ATP competitive and MT uncompetitive, only inhibiting the ATPase activity of the MT-bound motor protein. BTB-1 could serve as a valuable tool in disentangling the nature of Kif18A's double functionality within mitosis and assessing for potential therapeutic utilities. Synonyms: BTB 1; BTB1; 4-Chloro-2-nitro-1-(phenylsulfonyl)benzene; 4-Chloro-2-nitrodiphenyl sulfone; NSC 156750. CAS No. 86030-08-2. Molecular formula: C12H8ClNO4S. Mole weight: 297.71. | |
| Dimethylenastron | Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 (IC50 = 200 nM).The inhibition of kinesin Eg5 by small molecules such as monastrol is currently evaluated as an approach to develop a novel class of antiproliferative drugs for the treatment of malignant tumours. Synonyms: Dimethylenastron. Grade: 98%. CAS No. 863774-58-7. Molecular formula: C16H18N2O2S. Mole weight: 302.39. | |
| Eg5-I | Eg5, also known as KSP and Kif11, is a kinesin-like spindle protein that is essential for establishing a bipolar spindle during mitosis. Eg5-I is a potent inhibitor of Eg5, both in vitro and in cells (IC50s = 127 and 190 nM, respectively). Synonyms: (2R)-2-amino-3-[[(4-methoxyphenyl)diphenylmethyl]thio]-1-propanol. Grade: ≥98%. CAS No. 1338701-15-7. Molecular formula: C23H25NO2S. Mole weight: 379.5. | |
| Eg5 Inhibitor V, trans-24 | Eg5 Inhibitor V, trans-24 is a potent and specific inhibitor of kinesin Eg5 with an IC50 of 0.65 μM. It can be used in cancer research. Synonyms: 1H-Imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione, 5,6,11,11a-tetrahydro-5-(3-hydroxyphenyl)-2-(phenylmethyl)-, (5R,11aS)-; (5R,11aS)-2-Benzyl-5-(3-hydroxyphenyl)-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione; Trans-24. Grade: ≥95%. CAS No. 869304-55-2. Molecular formula: C26H21N3O3. Mole weight: 423.46. | |
| EMD534085 | EMD534085 is a potent and selective mitotic kinesin-5 inhibitor with an IC50 of 8 nM. Synonyms: 1-(2-(Dimethylamino)ethyl)-3-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano(3,2-C)quinolin-2-yl)methyl)urea; EMD-534085; EMD 534085; N-[2-(Dimethylamino)ethyl]-N'-[[(2R,4aS,5R,10bS)-3,4,4a,5,6,10b-hexahydro-5-phenyl-9-(trifluoromethyl)-2H-pyrano[3,2-c]quinolin-2-yl]methyl]urea. Grade: ≥95%. CAS No. 858668-07-2. Molecular formula: C25H31F3N4O2. Mole weight: 476.53. | |
| Filanesib | Filanesib, also known as ARRY-520, is a synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Synonyms: ARRY-520; ARRY 520; ARRY520. Grade: 0.98. CAS No. 885060-09-3. Molecular formula: C20H22F2N4O2S. Mole weight: 420.479. | |
| Filanesib | Filanesib (ARRY-520) is a selective and noncompetitive kinesin spindle protein ( KSP ) inhibitor, with an IC 50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARRY-520. CAS No. 885060-09-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15187. | |
| Filanesib TFA | Filanesib TFA is a selective inhibitor of kinesin spindle protein (KSP) (IC50 = 6 nM for human KSP), with potent anti-proliferative activity. It induces cell death by apoptosis in vitro. Synonyms: ARRY-520 TFA; (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide trifluoroacetate; Acetic acid, 2,2,2-trifluoro-, compd. with (2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide (1:1). CAS No. 1781834-99-8. Molecular formula: C22H23F5N4O4S. Mole weight: 534.50. | |
| Fmoc-Cys(Trt)-OH-[13C3,15N] | S-trityl-L-Cysteine-13C3,15N-N-FMOC is a labelled FMOC-S-trityl-L-cysteine. S-trityl-L-Cysteine, also known as KSP and Kif11, is an Eg5 inhibitor. Eg5 is a kinesin essential for mitotic spindle formation. Synonyms: N-Fmoc-S-trityl-L-cysteine 13C3,15N. Grade: 98% by CP; 99% atom 13C; 99% atom 15N. Molecular formula: C34[13C]3H31[15N]O4S. Mole weight: 589.7. | |
| Fmoc-S-Trityl-L-Cysteine-[3,3-d2] | Fmoc-S-Trityl-L-Cysteine-[3,3-d2] is a labelled Fmoc-S-Trityl-L-Cysteine. S-trityl-L-Cysteine, also known as KSP and Kif11, is an Eg5 inhibitor. Eg5 is a kinesin essential for mitotic spindle formation. Synonyms: S-trityl-L-Cysteine-3,3-d2-N-Fmoc; Fmoc-Cys(Trt)-OH-d2. Grade: 98% by HPLC; 98% atom D. CAS No. 360565-11-3. Molecular formula: C37H29D2NO4S. Mole weight: 589.72. | |
| GSK-923295 | GSK-923295 is a special, allosteric inhibitor of centromere-associated protein-E (CENP-E) kinesin motor ATPase activity, with Ki of 3.2±0.2 nM and 1.6± 0.1 nM for human and canine, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1088965-37-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10299. | |
| GW406108X | GW406108X is a Kif15 (Kinesin-12) inhibito. GW406108X inhibits ULK1 and autophagy flux in cells. Synonyms: GW108X. CAS No. 1644443-92-4. Molecular formula: C20H11Cl2NO4. Mole weight: 400.21. | |
| GW406108X(Z/E) | GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1. CAS No. 265098-01-9. Molecular formula: C20H11Cl2NO4. Mole weight: 400.21. | |
| Ispinesib | Ispinesib is a specific inhibitor of kinesin spindle protein (KSP) , with a K i app of 1.7 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-715992. CAS No. 336113-53-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50759. | |
| KIF18A-IN-1 | KIF18A-IN-1 is an inhibitor of the mitotic kinesin KIF18A with anti-tumor activity. KIF18A targeted inhibitors may activate mitotic checkpoints and selectively kill chromosomally unstable cancer cells[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2600559-12-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145034. | |
| Litronesib | Litronesib (LY2523355) is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY2523355. CAS No. 910634-41-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14846. | |
| Methyl Triphenylmethyl Ether | A trityl-cysteine analog as inhibitor of human mitotic kinesin. Group: Biochemicals. Alternative Names: 1, 1', 1''- (Methoxymethylidyne) trisbenzene. Grades: Highly Purified. CAS No. 596-31-6. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| MK-0731 | MK-0731 is a selective, non-competitive and allosteric kinesin spindle protein (KSP) inhibitor with an IC50 of 2.2 nM and a pKa of 7.6. MK-0731 is >20,000 fold selectivity against other kinesins. MK-0731 induces mitotic arrest and induces apoptosis in tumors. MK-0731 provides significant antitumor efficacy[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 845256-65-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-50672. | |
| Monastrol | Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC50 value of 14 ?M. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (±)-Monastrol. CAS No. 329689-23-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101071A. | |
| Monastrol (6-Methyl-4-(3-hydroxyphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate) | A cell-permeablesmall molecule inhibitor of the mitotic kinesin, Eg5, arrests cells in mitosis with monoastral spindles. Group: Biochemicals. Alternative Names: 6-Methyl-4-(3-hydroxyphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| N4-Benzoyl-2'-deoxycytidine | N-Benzoyldeoxycytidine is proetected Deoxycytidine (2'-deoxy) which is an Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity. Synonyms: N-[1-(2-Deoxy-β-D-erythro-pentofuranosyl)-1,2-dihydro-2-oxo-4-pyrimidinyl]-benzamide; 4-N-Benzoyldeoxycytidine; N-Benzoyl-2'-deoxycytidine; N4-Benzoyl-2'-deoxycytidine; N4-Benzoyldeoxycytidine. Grade: 98%. CAS No. 4836-13-9. Molecular formula: C16H17N3O5. Mole weight: 331.32. | |
| Paprotrain | Cell permeable kinesin-specific MKLP-2 (mitotic kinesin-like protein 2) inhibitor. Inhibits the recruitment of the chromosome passenger proteins survivin and aurora B to the central spindle during anaphase chromosome segregation. Group: Biochemicals. Grades: Highly Purified. CAS No. 57046-73-8. Pack Sizes: 1mg. Molecular Formula: C16H11N3. US Biological Life Sciences. | Worldwide |
| Paprotrain | Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 ?M and a Ki of 3.36 ?M and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 57046-73-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101298. | |
| proteasome ATPase | Belongs to the AAA-type superfamily and, like EC 3.6.4.5 (minus-end-directed kinesin ATPase), is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome. Group: Enzymes. Enzyme Commission Number: EC 3.6.4.8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4710; proteasome ATPase; EC 3.6.4.8. Cat No: EXWM-4710. | |
| SB-743921 hydrochloride | SB-743921 hydrochloride is a potent inhibitor of the mitotic kinesin KSP (Eg5) , with a K i of 0.1 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 940929-33-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12069. | |
| Sovilnesib | Sovilnesib (AMG 650) is a potent, orally active kinesin-like protein KIF18A inhibitor with an IC50 value of 0.071 ?M. Sovilnesib can be used for the research of cancer[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AMG 650. CAS No. 2410796-79-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132840. | |
| S-Trityl-L-cysteine | S-Trityl-L-cysteine is a cell-permeable, potent and selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. S-Trityl-L-cysteine inhibits basal and microtubule-activated ATPase activity of Eg5 (IC50 = 1 mM and 140 nM, respectively). S-Trityl-L-cysteine was shown to induce mitotic arrest in HeLa cells with an IC50 of 700 nM. Synonyms: S-(Triphenylmethyl)-L-cysteine. Grade: ≥ 98% (HPLC). CAS No. 2799-7-7. Molecular formula: C22H21NO2S. Mole weight: 363.47. | |
| S-Trityl-L-cysteine | S-Trityl-L-cysteine (NSC 83265) is a selective and allosteric kinesin Eg5 inhibitor with an IC50 of 1 ?M for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. S-Trityl-L-cysteine has antitumor activities[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 83265; S-Tritylcysteine; 3-Tritylthio-L-alanine. CAS No. 2799-7-7. Pack Sizes: 10 mM * 1 mL; 50 mg. Product ID: HY-W011102. | |
| Terpendole E (1'alpha-Hydroxy-Paspaline) | Inhibitor to Acyl-CoA: Cholesterol acyltransferase (ACAT), Mitotic kinesin Eg5 (Mitotic Kinesin Spindle Protein; KSP) and Specific M phase. Group: Biochemicals. Alternative Names: 1'alpha-Hydroxy-Paspaline. Grades: Highly Purified. CAS No. 167427-23-8. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| Triphenylmethylamine | Triphenylmethylamine is a trityl derivative that is structurally related to Clotrimazole. Triphenylmethylamine is used in the preparation of trityl-cysteine analogs as inhibitors of human mitotic kinesin. Triphenylmethylamine is also used as a fireproofing agent. Group: Biochemicals. Alternative Names: α , α -Diphenyl Benzene methanamine; Tritylamine; Aminotriphenylmethane; NSC 1154; Triphenylmethanamine. Grades: Highly Purified. CAS No. 5824-40-8. Pack Sizes: 25g. US Biological Life Sciences. | Worldwide |
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