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| Product | Description | |
|---|---|---|
| KN 93 | KN 93. Group: Biochemicals. Grades: Purified. CAS No. 139298-40-1. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| KN 93 phosphate | KN 93 phosphate. Group: Biochemicals. Grades: Purified. CAS No. 1188890-41-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| KN-93 | KN-93 is a selective Ca2+/calmodulin-dependent protein kinase II inhibitor, which has been implicated in the regulation of smooth muscle contractility. CaM kinase II activation was inhibited by KN-93 pretreatment (IC50 ~1 μM). KN-93 inhibited histamine-induced tonic force maintenance, whereas early force development and MLC20 phosphorylation responses during the entire time course were unaffected. Both force development and maintenance in response to KCl were inhibited by KN-93. Rapid increases in KCl-induced MLC20 phosphorylation were also inhibited by KN-93, whereas steady-state MLC20 phosphorylation responses were unaffected. In contrast, phorbol 12,13-dibutyrate (PDBu) did not activate CaM kinase II and PDBu-stimulated force development was unaffected by KN-93. Thus KN-93 appears to target a step(s) essential for force maintenance in response to physiological stimuli, suggesting a role for CaM kinase II in regulating tonic contractile responses in arterial smooth muscle. Pharmacological activation of protein kinase C bypasses the KN-93 sensitive step. Uses: Protein kinase inhibitors. Synonyms: KN 93; KN93. Grades: >98%. CAS No. 139298-40-1. Molecular formula: C26H29ClN2O4S. Mole weight: 501.04. |  |
| KN-93 Phosphate | KN-93 Phosphate is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities. Synonyms: (E)-N- (2- ( ( (3- (4-chlorophenyl)allyl) (methyl)amino)methyl)phenyl)-N- (2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate; KN93; KN 93; KN-93; KN-93 phosphate. Grades: >98%. CAS No. 1188890-41-6. Molecular formula: C26H32ClN2O8PS. Mole weight: 599.03. | |
| 1-Bromo-2,5,8,11,14-heptadecapentayne | 1-Bromo-2,5,8,11,14-heptadecapentayne is an unsaturated compound that is related to Arachidonic acid (A3303). Arachidonic acid is membrane phospholipid component of mammalian cells that is known to give the cell membranes their correct fluidity. Arachidonic acid also directly activates potassium channels in smooth muscle. Group: Biochemicals. Grades: Highly Purified. CAS No. 93322-84-0. Pack Sizes: 25mg, 250mg. Molecular Formula: C17H15Br, Molecular Weight: 299.2. US Biological Life Sciences. | Worldwide |
| 2,5,8,11,14-Heptadecapentayn-1-ol | 2,5,8,11,14-Heptadecapentayn-1-ol is an unsaturated compound that is related to Arachidonic acid (A3303). Arachidonic acid is membrane phospholipid component of mammalian cells that is known to give the cell membranes their correct fluidity. Arachidonic acid also directly activates potassium channels in smooth muscle. Group: Biochemicals. Grades: Highly Purified. CAS No. 93318-79-7. Pack Sizes: 25mg, 250mg. Molecular Formula: C17H16O, Molecular Weight: 236.31. US Biological Life Sciences. | Worldwide |
| 8-[(6-Amino)hexyl]-amino-cAMP - ATTO-620 | 8-[(6-Amino)hexyl]-amino-cAMP - ATTO-620, an exemplary fluorescent labeling probe essential in shedding light on cAMP signaling pathways, is widely used in biomedical research. Labeling of cell membranes and intracellular compartments using this product is indeed suitable, thereby amplifying knowledge about biomedical mechanisms of interest. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-cyclic monophosphate, labeled with ATTO 620, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O6P - ATTO 620 (free acid). Mole weight: 936.39 (free acid). | |
| BI 6015 | BI 6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that suppresses expression of known HNF4α target genes. BI 6015 produces cytotoxicity in a range of tumor cell lines, including human hepatocellular carcinoma. Synonyms: BI6015; BI 6015; BI-6015. 2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole. Grades: ≥98% by HPLC. CAS No. 93987-29-2. Molecular formula: C15H13N3O4S. Mole weight: 331.35. | |
| Cobimetinib racemate | Cobimetinib racemate is a selective inhibitor of MEK. It is also known as mitogen activated protein kinase kinase (MAPKK) and is a key component of the RAS/RAF/MEK/ERK pathway, which is frequently activated in human tumors. Synonyms: GDC-0973 racemate; XL-518; GDC 0973 racemate; XL 518; GDC0973 racemate; XL518. Grades: >98%. CAS No. 934662-91-6. Molecular formula: C21H21F3IN3O2. Mole weight: 531.31. | |
| Cobimetinib (R-enantiomer) | Cobimetinib (R-enantiomer) is a selective inhibitor of MEK. It is also known as mitogen activated protein kinase kinase (MAPKK) and is a key component of the RAS/RAF/MEK/ERK pathway, which is frequently activated in human tumors. Synonyms: GDC-0973 R-enantiomer; XL-518 R-enantiomer; GDC0973 R-enantiomer; XL518 R-enantiomer; GDC 0973 R-enantiomer; XL 518 R-enantiomer. Grades: >98%. CAS No. 934660-94-3. Molecular formula: C21H21F3IN3O2. Mole weight: 531.31. | |
| Elinogrel | Elinogrel, also known as PRT 060128, is P2Y12 inhibitor. Similarly to ticagrelor and in contrast to clopidogrel, elinogrel was a reversible inhibitor that acted fast and short (for about 12 hours), and it was not a prodrug but pharmacologically active itself. The substance was used in form of its potassium salt, intravenously for acute treatment and orally for long-term treatment. Development was terminated in 2012. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PRT 060128; PRT-060128; PRT060128; Elinogrel. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 936500-94-6. Molecular formula: C20H15ClFN5O5S2. Mole weight: 523.94. Purity: >98%. IUPACName: 5-chloro-N-((4-(6-fluoro-7-(methylamino)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)phenyl)carbamoyl)thiophene-2-sulfonamide. Canonical SMILES: O=C(NC1=CC=C(N2C(NC3=C(C=C(F)C(NC)=C3)C2=O)=O)C=C1)NS(=O)(C4=CC=C(Cl)S4)=O. Product ID: ACM936500946-1. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Fazarabine | Fazarabine, also known as Kymarabine, is an orally-active pyrimidine analogue of an aza-substituted cytidine in which the ribose moiety is replaced by an arabinose sugar. Similar in action to cytarabine, fazarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; its incorporation into DNA inhibits DNA synthesis, resulting in tumor cell death and tumor necrosis. The presence of deoxycytidine kinase in a tumor is a determinant of tumor sensitivity to this drug. Synonyms: CCRIS 93; CCRIS-93; CCRIS93; NSC 281272; NSC-281272; NSC281272; Ara-AC; 5-Azacytosine arabinoside; 1-beta-D-Arabinofuranosyl-5-azacytosine. CAS No. 65886-71-7. Molecular formula: C8H12N4O5. Mole weight: 244.20. | |
| Fluorescent Brightener 71-d10 | Fluorescent Brightener 71-d10 is deuterium labelled form of Fluorescent Brightener 71 (F596080). Fluorescent (optical) brighteners are known for their characteristics of protecting baculoviruses against deactivation by UV light and enhancing the activity of these agents as microbial insecticides on hosts and semipermissive hosts. Fluorescent brighteners improve the bioinsecticidal activity of Anticarsia gemmatalis nucleopolyhedrovirus. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C40H28D10N12Na2O8S2, Molecular Weight: 934.98. US Biological Life Sciences. | Worldwide |
| HT-61 | HT-61, also known as HY-50A, is a pyrroloquinolone antibiotic potentially for the treatment of staphylococcal infections. HT61 was effective at reducing biofilm viability and was associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections. HT61 enhances the effect of tobramycin against Pseudomonas aeruginosa in vitro and in vivo. Uses: Designed for use in research and industrial production. Additional or Alternative Names: HT-61; HT61; HT 61; HY-50A; HY 50A; HY50A. Product Category: Others. Appearance: Solid powder. CAS No. 936622-80-9. Molecular formula: C26H24N2O. Mole weight: 380.49. Purity: >98%. IUPACName: 4-methyl-1-phenethyl-8-phenoxy-2,3-dihydro-1H-pyrrolo[3,2-c]quinoline. Canonical SMILES: CC1=NC2=CC=C(OC3=CC=CC=C3)C=C2C4=C1CCN4CCC5=CC=CC=C5. Product ID: ACM936622809. Alfa Chemistry ISO 9001:2015 Certified. Categories: HQ-6. | |
| Ibrutinib, Free Base | Ibrutinib, also known as PCI-32765, is a selective and irreversible inhibitor of the enzyme Bruton's tyrosine kinase (BTK). It inhibited BTK potently, with an IC50 of 0.72 nM in enzymology assays and with an IC50 of 10 nM in cellular assay with Ramos cells. It demonstrated preference toward BTK over closely related kinases, blocked B cell function and BTK-dependent processes, and demonstrated clear efficacy in a mouse arthritis model. Young P.R., et al. "Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase." ChemMedChem. 2: 58-61 (2007). Group: Biochemicals. Alternative Names: 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one; PCI 32765; PCI 32765-00; CRA 032765; (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one; Imbruvica. Grades: Purified. CAS No. 936563-96-1. Pack Sizes: 5mg, 25mg, 50mg. US Biological Life Sciences. | Worldwide |
| Irbinitinib | Irbinitinib,also known as ARRY-380 and ONT-380, is an orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation. Uses: Antineoplastic agents. Synonyms: ARRY-380; ARRY 380; ARRY380; ONT-380; ONT-380; ONT-380. Grades: 0.98. CAS No. 937263-43-9. Molecular formula: C26H24N8O2. Mole weight: 480.532. | |
| KN-92 phosphate | KN-92 is an inactive analog of the CaM kinase II inhibitor KN 93. Synonyms: KN-92 phosphate; KN 92 phosphate; KN92 phosphate. Grades: >98%. CAS No. 1135280-28-2. Molecular formula: C24H28ClN2O7PS. Mole weight: 554.98. | |
| NMS-1286937 | NMS1286937, also know as NMS-P937, is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor NMS-1286937 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressing tumor cells. PLK1 is a serine/threonine protein kinase crucial in the regulation of mitosis. Uses: Protein kinase inhibitors. Synonyms: PCM-075; PCM 075; PCM075; NMS1286937; NMS 1286937; NMS-1286937; NMS-P937; NMS-P-937; NMS-P 937; Onvansertib. Grades: >98%. CAS No. 1034616-18-6. Molecular formula: C24H27F3N8O3. Mole weight: 532.53. | |
| Oprozomib | Oprozomibm, also known as ONX 0912 and PR 047, is an orally bioavailable proteasome inhibitor with potential antineoplastic activity. ONX 0912 inhibits the activity of the proteasome, thereby blocking the targeted proteolysis normally performed by the proteasome; this may result in an accumulation of unwanted or misfolded proteins. Disruption of various cell signaling pathways may follow, eventually leading to the induction of apoptosis and inhibition of tumor growth. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquitinated. Synonyms: ONX0912; ONX-0912; ONX 0912; PR047; PR-047; PR 047. Grades: >98%. CAS No. 935888-69-0. Molecular formula: C25H32N4O7S. Mole weight: 532.60918. | |
| Panax Notoginseng Extract | Panax notoginseng extract is prepared from the species of the genus Panax, also known as sanqi extract powder. Panax notoginseng extract powder contain high potency notoginsenoside, Ginsenoside Rb1, Ginsenoside Rg1, Ginsenoside Rd, Ginsenoside Re, and Ginsenoside Rb2, which are most active ingredients impacting on your overall health and nutritionally support healthy heart function, blood circulation, and performance. Group: Others. Mole weight: 933.14. Panax Notoginseng Extract; Panax Pseudo-Ginseng Wall. Var. Cat No: EXTC-016. |  |
| Pilaralisib | Pilaralisib, also known as XL147, is a methylbenzenesulfonamide derivative that reversibly inhibits class I PI3Ks (IC50s = 39, 36, 23, and 383 nM for p110α, δ, γ, and β, respectively), with potential antineoplastic activity. Synonyms: 2-amino-N-(3-(N-(3-((2-chloro-5-methoxyphenyl)amino)quinoxalin-2-yl)sulfamoyl)phenyl)-2-methylpropanamide.; XL147; XL 147; XL-147; SAR245408; SAR-245408; SAR 245408; Pilaralisib. CAS No. 934526-89-3. Molecular formula: C25H25ClN6O4S. Mole weight: 541.02. | |
| Remacemide hydrochloride | Remacemide, also known as PR-934423 and FPL 12924AA, is a non-competitive NMDA receptor antagonist, which blocks ion channel and allosteric modulatory site (IC50 = 8-68 mM). Remacemide Hydrochloride has been used in pharmaceutical studies as a potential treatment to ischemic stroke, epilepsy, Parkinson's disease and Huntington's disease. Synonyms: 2-Amino-N-(1-methyl-1,2-diphenylethyl)acetamide hydrochloride; PR-934423; PR934423 PR 934423; PR 934-423A; FPL 12924AA; Remacemide hydrochloride. Grades: ≥99% by HPLC. CAS No. 111686-79-4. Molecular formula: C17H20N2O.HCl. Mole weight: 304.82. | |
| RO5045337 | RO5045337, also known as R7112, RG7112, is a MDM2 antagonist with potential antineoplastic activity. RO5045337 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored, which may result in the restoration of p53 signaling and thus the p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, it has been implicated in cancer cell proliferation and survival. Synonyms: R7112, RG7112, RG 7112; RG-7112; RO5045337; RO 5045337; RO-5045337. CAS No. 939981-39-2. Molecular formula: C38H48Cl2N4O4S. Mole weight: 727.786. | |
| scutelarin | From the venom of the Taipan snake (Oxyuranus scutellatus). Converts prothrombin to thrombin. Specificity is similar to that of Factor Xa (EC 3.4.21.6). However, unlike Factor Xa this enzyme can cleave its target in the absence of coagulation Factor Va. Activity is potentiated by phospholipid and Ca2+ which binds via γ-carboxyglutamic acid residues. Similar enzymes are known from the venom of other Australian elapid snakes, including Pseudonaja textilis textilis, Oxyuranus microlepidotus and Demansia nuchalis affinis. Group: Enzymes. Synonyms: taipan activator; Oxyuranus scutellatus prothrombin-activating proteinase. Enzyme Commission Number: EC 3.4.21.60. CAS No. 93389-45-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4151; scutelarin; EC 3.4.21.60; 93389-45-8; taipan activator; Oxyuranus scutellatus prothrombin-activating proteinase. Cat No: EXWM-4151. | |
| SKQ1 | SKQ1, also known as plastoquinonyl decyltriphenyl phosphonium or PDTP, is a potent mitochondria-targeted antioxidant. SKQ1 is also an API (active pharmaceutical ingredient) for making eye drop drug called Visomitin. Synonyms: SKQ1; SKQ 1; SKQ-1; PDTP; Plastoquinonyl decyltriphenyl phosphonium bromide; Visomitin. Grades: 95%. CAS No. 934826-68-3. Molecular formula: C36H42BrO2P. Mole weight: 617.61. | |
| Tanzisertib | Tanzisertib, also known as CC-930, is a potent, selective, and orally active JNK inhibitor with potential antifibrotic activity. CC-930 entered Phase I clinical trials. Tanzisertib may have potential use for prevention and treatment of dermal fibrosis. Selective inhibition of JNK by CC-930 exerted potent antifibrotic effects in vitro and in different models in vivo. JNK might thus be a novel molecular target for the treatment of fibrosis in SSc. Synonyms: CC930, CC-930, CC 930, Tanzisertib, JNK-930, JNKI-1, JNK930, JNKI1, JNK 930, JNKI 1. Grades: >98%. CAS No. 899805-25-5. Molecular formula: C21H23F3N6O2. Mole weight: 448.45. | |
| Umbelliferone | Umbelliferone, which is extracted from the root of Angelica biserrata (Shan et Yuan) Yuan et Shan, also known as 7-hydroxycoumarin, hydrangine, skimmetine, and beta-umbelliferone, is a widespread natural product of the coumarin family. It is a yellowish-white crystalline solid that has a slight solubility in hot water, but high solubility in ethanol. Uses: Anti-nociceptive, anti-inflammatory,anti-cancer, anti-oxidant. Synonyms: 7-hydroxy-1-benzopyran-2-one;7-Hydroxycoumarin. Grades: >98%. CAS No. 93-35-6. Molecular formula: C9H6O3. Mole weight: 162.1. | |
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