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Kynurenicacid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenicacid is also an agonist of GPR35/CXCR8. Uses: Scientific research. Group: Natural products. Alternative Names: Quinurenic acid. CAS No. 492-27-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-100806.
Kynurenicacid
Kynurenicacid is a product of L-Tryptophan metabolism. It is a non-selective antagonist at NMDA and AMPA/kainate receptors. It could block kainic acid neurotoxicity. It has neruoactive activity having anticonvulsant and antiexcitotoxic properties. Uses: Excitatory amino acid antagonists. Synonyms: 4-Hydroxy-2-quinolinecarboxylic Acid; 4-Hydroxy-quinaldic Acid; 2-Carboxy-4-hydroxyquinoline; 4-Hydroxyquinaldic Acid; Quinurenic Acid; NSC 58973; 4-Hydroxyquinoline-2-carboxylic acid. Grades: ≥98% by HPLC. CAS No. 492-27-3. Molecular formula: C10H7NO3. Mole weight: 189.17.
KynurenicAcid
A product of L-Tryptophan metabolism, possessing neuroactive activity having antiexcitotoxic and anticonvulsant properties. Group: Biochemicals. Alternative Names: 4-Hydroxy-2-quinolinecarboxylic Acid; 4-Hydroxy-quinaldic Acid; 2-Carboxy-4-hydroxyquinoline; 4-Hydroxyquinaldic Acid; 4-Hydroxyquinaldinic Acid; Quinurenic Acid; NSC 58973. Grades: Highly Purified. CAS No. 492-27-3. Pack Sizes: 10mg, 100mg, 500mg, 1g. Molecular Formula: C10H7NO3, Melting Point: 256-258°C (dec.). US Biological Life Sciences.
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KynurenicAcid-d5
A labeled product of L-Tryptophan metabolism, possessing neruoactive activity having antiexcitotoxic and anticonvulsant properties. Group: Biochemicals. Alternative Names: 4-Hydroxy-2-quinolinecarboxylic Acid-d5; 4-Hydroxy-quinaldic Acid-d5; 2-Carboxy-4-hydroxyquinoline-d5; 4-Hydroxyquinaldic Acid-d5; 4-Hydroxyquinaldinic Acid-d5; Quinurenic Acid-d5; NSC 58973-d5. Grades: Highly Purified. CAS No. 350820-13-2. Pack Sizes: 2.5mg. US Biological Life Sciences.
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KynurenicAcid Impurity 1
KynurenicAcid Impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 18000-24-3. Molecular Formula: C10H6ClNO3. Mole Weight: 223.61. Catalog: APB18000243.
KynurenicAcid Impurity 2
KynurenicAcid Impurity 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 131123-76-7. Molecular Formula: C10H5Cl2NO3. Mole Weight: 258.05. Catalog: APB131123767.
Kynurenicacid sodium
Kynurenicacid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenicacid sodium is also an agonist of GPR35/CXCR8. Uses: Scientific research. Group: Natural products. CAS No. 2439-2-3. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-107512.
Kynurenicacid sodium salt
Kynurenicacid sodium salt. Group: Biochemicals. Grades: Purified. CAS No. 2439-2-3. Pack Sizes: 100mg. US Biological Life Sciences.
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Kynurenicacid sodium salt
Kynurenicacid sodium salt is the sodium form of kynurenicacid, which is a broad spectrum EAA antagonist. Synonyms: 4-Hydroxyquinoline-2-carboxylic acid sodium salt. Grades: ≥99% by HPLC. CAS No. 2439-2-3. Molecular formula: C10H6NNaO3. Mole weight: 211.15.
5,7-Dichlorokynurenicacid
5,7-Dichlorokynurenicacid (5,7-DCKA) is a selective and competitive antagonist of the glycine site on NMDA receptor with a K B of 65 nM. 5,7-Dichlorokynurenicacid, a derivative of kynurenicacid, reduced NMDA-induced neuron injury in rat cortical cell cultures [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 5,7-DCKA. CAS No. 131123-76-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100834.
Ivacaftor impurities8 (KynurenicAcid Impurity 4)
Ivacaftor impurities8 (KynurenicAcid Impurity 4). Uses: For analytical and research use. Group: Impurity standards. CAS No. 34785-11-0. Molecular Formula: C10H7NO3. Mole Weight: 189.17. Catalog: APB34785110.
2-Benzamido-2-methyl-4-(2-nitrophenyl)-4-oxobutanoic Acid Methyl Ester is an intermediate in the synthesis of rac Kyurenine (K661000), a tryptophan metabolite and the precursor of an antagonist of N-methyl-aspartate receptor, Kynurenicacid (K660500). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg. US Biological Life Sciences.
3-Benzoyl-4-(2-(2-nitrophenyl)-2-oxoethyl)-2-phenyloxazolidin-5-one is an intermediate in the synthesis of rac Kyurenine (K661000), a tryptophan metabolite and the precursor of an antagonist of N-methyl-aspartate receptor, Kynurenicacid (K660500). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250mg. US Biological Life Sciences.
4-(2-Aminophenyl)-2-benzamido-2-methyl-4-oxobutanoic Acid is an impurity of rac Kyurenine (K661000), a tryptophan metabolite and the precursor of an antagonist of N-methyl-aspartate receptor, Kynurenicacid (K660500). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
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4-Chloro Kynurenine-13C2,15N
7-Cl-kynurenicacid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application. Group: Biochemicals. Alternative Names: α,2-Diamino-4-chloro-γ-oxobenzenebutanoic Acid-13C2,15N; (+/-)-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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D-Kynurenine
a metabolite of D-tryptophan that is also a bioprecursor of two neuroactive compounds kynurenicacid (KYNA) and 3-hydroxykynurenine. Synonyms: (αR)-α,2-Diamino-γ-oxo-benzenebutanoic Acid; D-3-Anthraniloylalanine; (R)-α,2-Diamino-γ-oxo-benzenebutanoic Acid. Grades: > 95%. CAS No. 13441-51-5. Molecular formula: C10H12N2O3. Mole weight: 208.22.
DL-Homocysteine
DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenicacid in the brain. DL-Homocysteine is correlated with Vitamin B12, renal functions and folate levels, affects the cross-sectional cognition indirectly through white matter microstructural integrity [2]. Uses: Scientific research. Group: Natural products. CAS No. 454-29-5. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-W040821.
JM-6
JM6 is a prodrug inhibitor of kynurenine 3-monooxygenase (KMO). It could increase kynurenicacid levels and reduces extracellular glutamate in the brain. It prevents spatial memory deficits, anxiety-related behavior, and synaptic loss in mouse model of Alzheimer disease. It also extends life span, prevents synaptic loss, and decreases microglial activation in a mouse model of Huntington's disease. It also plays an important role in the inhibitory effects towards kynurenine 3-monooxygenase in blood ameliorates neurodegeneration, including Alzheimer's and Huntington's diseases. Uses: Jm6 plays an important role in the inhibitory effects towards kynurenine 3-monooxygenase in blood ameliorates neurodegeneration, including alzheimer's and huntington's diseases. Synonyms: JM6; JM-6; JM 6. 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-5-(1-piperidinylmethyl)-2-thiazolyl]-benzenesulfonamide;2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-nitrophenyl)-5-(piperidin-1-yl)methylthiazole. Grades: >98 %. CAS No. 1008119-83-2. Molecular formula: C23H26N4O6S2. Mole weight: 518.60.
KMO Inhibitor I, Ro 61-8048 (Kynurenine-3-Monooxygenase Inhibitor I, Ro 61-8048 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide Dimethoxy-nitrophenyl-thiazolyl-benzenesulfonamide, Kynurenine-3-Hydroxylase Inhibitor I, Ro 61-8048)
A cell-permeable thiazolyl Benzene sulfonamide compound that acts as a potent, competitive and reversible inhibitor of kynurenine-3-monooxygenase activity (Ki=4.8nM; IC50=37nM). Reported to increase the circulating levels of kynurenicacid (KYNA), an excitatory amino acid receptors antagonist, lower reactive oxygen species [ROS], reduce neuronal loss and enhance the survival rate in several neuronal disease models. An orally bioavilable KMO Inhibitor II, JM6, a prodrug of Ro 61-8048 is also available. Group: Biochemicals. Grades: Highly Purified. CAS No. 199666-03-0. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S?, Molecular Weight: 421.5. US Biological Life Sciences.
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kynurenate-7,8-dihydrodiol dehydrogenase
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 7,8-dihydro-7,8-dihydroxykynurenate:NAD+ oxidoreductase. Other names in common use include 7,8-dihydro-7,8-dihydroxykynurenate dehydrogenase, and 7,8-dihydroxykynurenicacid 7,8-diol dehydrogenase. This enzyme participates in tryptophan metabolism. Group: Enzymes. Synonyms: 7,8-dihydro-7,8-dihydroxykynurenate dehydrogenase; 7,8-dihydroxykynurenicacid 7,8-diol dehydrogenase. Enzyme Commission Number: EC 1.3.1.18. CAS No. 37255-30-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1292; kynurenate-7,8-dihydrodiol dehydrogenase; EC 1.3.1.18; 37255-30-4; 7,8-dihydro-7,8-dihydroxykynurenate dehydrogenase; 7,8-dihydroxykynurenicacid 7,8-diol dehydrogenase. Cat No: EXWM-1292.
kynurenine 7,8-hydroxylase
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating). Other names in common use include kynurenicacid hydroxylase, kynurenic hydroxylase, and kynurenate 7,8-hydroxylase. This enzyme participates in tryptophan metabolism. Group: Enzymes. Synonyms: kynurenicacid hydroxylase; kynurenic hydroxylase; kynurenate 7,8-hydroxylase. Enzyme Commission Number: EC 1.14.99.2. CAS No. 9029-63-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1037; kynurenine 7,8-hydroxylase; EC 1.14.99.2; 9029-63-4; kynurenicacid hydroxylase; kynurenic hydroxylase; kynurenate 7,8-hydroxylase. Cat No: EXWM-1037.
rac α-Methyl Kynurenine
rac α-Methyl Kynurenine is an impurity of rac Kyurenine (K661000), a tryptophan metabolite and the precursor of an antagonist of N-methyl-aspartate receptor, Kynurenicacid (K660500). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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rac Kynurenine
A tryptophan metabolite, is a precursor of kynurenicacid, which is an antagonist of N-methyl-aspartate receptor. Group: Biochemicals. Alternative Names: α,2-Diamino-γ-oxo. Grades: Highly Purified. CAS No. 343-65-7. Pack Sizes: 5mg. US Biological Life Sciences.
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rac-Kynurenine
A tryptophan metabolite, is a precursor of kynurenicacid, which is an antagonist of N-methyl-aspartate receptor. Synonyms: 2-Amino-3-(2-aminobenzoyl)propionic acid, 2-Amino-4-(2-aminophenyl)-4-oxobutyric acid; DL-Kynurenine. Grades: > 95%. CAS No. 343-65-7. Molecular formula: C10H12N2O. Mole weight: 208.22.
2-Acetamido-2-(2-(2-amino-3-hydroxyphenyl)-2-oxoethyl)malonic Acid Diethyl Ester is an UV degradation product of 3-Hydroxy Kynurenine (H943695), a metabolite of tryptophan. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 25mg. Molecular Formula: C17H22N2O7. US Biological Life Sciences.
2-(Acetylamino)-2-[2-[2-nitro-3-(phenylmethoxy)phenyl]-2-oxoethyl]propanedioic Acid 1,3-Diethyl Ester is an UV degradation product of 3-Hydroxy Kynurenine (H943695), a metabolite of tryptophan. Group: Biochemicals. Grades: Highly Purified. CAS No. 224044-62-6. Pack Sizes: 5mg, 25mg. Molecular Formula: C24H26N2O9. US Biological Life Sciences.
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2-Amino-3-hydroxybenzoate Potassium Salt
2-Amino-3-hydroxybenzoate Potassium Salt is an intermediate used in the synthesis of 3-Hydroxyanthranillic Acid-d3 (H801792), which is the labeled analogue of 3-Hydroxyanthranillic Acid, one of the tryptophan metabolites along with the kynurenine pathways. 3-Hydroxyanthranilic Acid has been shown to induce apoptosis in T cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C7H6KNO3, Molecular Weight: 191.23. US Biological Life Sciences.
Worldwide
2-Amino-5-bromo-3-hydroxybenzoic Acid
2-Amino-5-bromo-3-hydroxybenzoic Acid is an intermediate used in the synthesis of 3-Hydroxyanthranillic Acid-d3 (H801792), which is the labeled analogue of 3-Hydroxyanthranilic Acid, one of the tryptophan metabolites along the kynurenine pathway. 3-Hydroxyanthranilic Acid has been shown to induce apoptosis in T cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C7H6BrNO3, Molecular Weight: 232.03. US Biological Life Sciences.
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2-(Bromomethyl)-1-chloro-3-nitrobenzene
2-(Bromomethyl)-1-chloro-3-nitrobenzene is a reactant in the synthesis of cyclic hydroxamic acid PF-04859989, a potent and selective inhibitor of human and rat Kynurenine aminotransferase II (KAT II) for treatment of schizophrenia. Group: Biochemicals. Grades: Highly Purified. CAS No. 56433-01-3. Pack Sizes: 100mg, 1g. Molecular Formula: C7H5BrClNO2, Molecular Weight: 250.48. US Biological Life Sciences.
Worldwide
3-Hydroxyanthranilic acid
3-Hydroxyanthranilic acid is a tryptophan metabolite in the kynurenine pathway.3-hydroxyanthranilic acid has anti-inflammatory, neuroprotective, and lipid-lowering effects. 3-hydroxyanthranilic acid can be used for researches of cardiovascular diseases, tumors, and metabolic diseases [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. CAS No. 548-93-6. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-W001171.
3-Hydroxyanthranilic Acid
3-Hydroxy anthranilic acid is an intermediate in the oxidative metabolism of tryptophan in the kynurenine pathway that demonstrates immunoprotective effects. Uses: Free radical scavengers. Synonyms: 2-amino-3-hydroxybenzoic acid; 2-amino-3-hydroxybenzoic acid. Grades: ≥ 98 %. CAS No. 548-93-6. Molecular formula: C7H7NO3. Mole weight: 153.14.
3-Hydroxy-DL-kynurenine
3-Hydroxy-DL-kynurenine is an active metabolite of tryptophan. Synonyms: Benzenebutanoic acid, α,2-diamino-3-hydroxy-γ-oxo-; Alanine, 3-(3-hydroxyanthraniloyl)-; α,2-Diamino-3-hydroxy-γ-oxobenzenebutanoic acid; 3-Hydroxykynurenine; DL-3-Hydroxykynurenine; Hydroxykynurenine. Grades: ≥98%. CAS No. 484-78-6. Molecular formula: C10H12N2O4. Mole weight: 224.21.
aromatic-amino-acid-glyoxylate transaminase
Phenylalanine, kynurenine, tyrosine and histidine can act as amino donors; glyoxylate, pyruvate and hydroxypyruvate can act as amino acceptors. Group: Enzymes. Enzyme Commission Number: EC 2.6.1.60. CAS No. 67185-76-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2902; aromatic-amino-acid-glyoxylate transaminase; EC 2.6.1.60; 67185-76-6. Cat No: EXWM-2902.
BFF 122
BFF 122 is a potent and selective inhibitor of kynurenine aminotransferase II (IC50 = 1 μM and >30 μM for KAT II and KAT I respectively). Synonyms: BFF122; BFF 122; BFF-122; BF5; (S)-9-(4-Amino-piperazin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid. Grades: 99%. CAS No. 1152314-49-2. Molecular formula: C17H19FN4O4. Mole weight: 362.36.
Cinnabarinic acid
Cinnabarinic acid is a kynurenine pathway metabolite of tryptophan and is produced by the oxidation of 3-Hydroxyanthranilic acid. It is a metabotropic glutamate receptor (mGlu4R-specific) agonist. It activates mGlu4 receptors in transiently transfected HEK293 cells and is selective over all other mGlu subtypes. It decreases cAMP levels in native cultured cerebellar granule cells. It may be used in studies of the functions of components of the kynurenine metabolic pathway. It leads to loss of apoptosis and mitochondrial respiration. It induces apoptosis in thymocytes by the generation of reactive oxygen species. It also counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells. It has neuroprotective activity. Synonyms: 2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid. Grades: ≥98% by HPLC. CAS No. 606-59-7. Molecular formula: C14H8N2O6. Mole weight: 300.22.
Cinnabarinic acid
Cinnabarinic acid is a specific orthosteric agonist of mGlu 4 by interacting with residues of the glutamate binding pocket of mGlu4, has no activity at other mGlu receptors. Cinnabarinic acid is an endogenous metabolite of the kynurenine pathway of tryptophan. Cinnabarinic acid induces cell apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 606-59-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W011417.
L-Kynurenine
a product of constitutive tryptophan catabolism via tryptophan-2,3-dioxygenase in the liver and human gliomas that is associated with the suppression of antitumor immune responses. Synonyms: L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid. Grades: > 95%. CAS No. 2922-83-0. Molecular formula: C10H12N2O3. Mole weight: 208.22.
L-Kynurenine
L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist. Uses: Scientific research. Group: Natural products. CAS No. 2922-83-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-104026.
L-Kynurenine (Standard)
L-Kynurenine (Standard) is the analytical standard of L-Kynurenine. This product is intended for research and analytical applications. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist. Uses: Scientific research. Group: Natural products. CAS No. 2922-83-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104026R.
N-Formyl Kynurenine
a photooxidation product of Tryptophan. Synonyms: 2-amino-4-(2-formamidophenyl)-4-oxo-butanoic acid; α-Amino-2-(formylamino)-γ-oxo-Benzenebutanoic Acid; 3-(N-Formylanthraniloyl)alanine; Formylkynurenine; N-Formylkynurenine. Grades: > 95%. CAS No. 1022-31-7. Molecular formula: C11H12N2O4. Mole weight: 236.23.
N-Formyl-L-kynurenine
N-Formylkynurenine is a L-kynurenine derivative. Synonyms: (S)-2-Amino-4-(2-formamidophenyl)-4-oxobutanoic acid. CAS No. 3978-11-8. Molecular formula: C11H12N2O4. Mole weight: 236.22.
NLG-919
NLG919 is an orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), a cytosolic enzyme responsible for the oxidation of the essential amino acid tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, this agent increases tryptophan levels, restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs). Synonyms: GDC0919; GDC-0919; GDC 0919; NLG919; NLG 919; NLG-919; RG6078; RG-6078; RG 6078. Grades: > 98%. CAS No. 1402836-58-1. Molecular formula: C18H22N2O. Mole weight: 282.38.
Quinolinic acid
Quinolinic acid is an endogenous N-methyl-D-aspartate ( NMDA ) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 89-00-9. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 10 g. Product ID: HY-100807.
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