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| Product | Description | |
|---|---|---|
| kynurenine 3-monooxygenase | A flavoprotein (FAD). Group: Enzymes. Synonyms: kynurenine 3-hydroxylase; kynurenine hydroxylase; L-kynurenine-3-hydroxylase. Enzyme Commission Number: EC 1.14.13.9. CAS No. 9029-61-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0898; kynurenine 3-monooxygenase; EC 1.14.13.9; 9029-61-2; kynurenine 3-hydroxylase; kynurenine hydroxylase; L-kynurenine-3-hydroxylase. Cat No: EXWM-0898. |  |
| kynurenine 7,8-hydroxylase | This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating). Other names in common use include kynurenic acid hydroxylase, kynurenic hydroxylase, and kynurenate 7,8-hydroxylase. This enzyme participates in tryptophan metabolism. Group: Enzymes. Synonyms: kynurenic acid hydroxylase; kynurenic hydroxylase; kynurenate 7,8-hydroxylase. Enzyme Commission Number: EC 1.14.99.2. CAS No. 9029-63-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1037; kynurenine 7,8-hydroxylase; EC 1.14.99.2; 9029-63-4; kynurenic acid hydroxylase; kynurenic hydroxylase; kynurenate 7,8-hydroxylase. Cat No: EXWM-1037. | |
| kynurenine-glyoxylate transaminase | Acts, more slowly, on L-phenylalanine, L-histidine and L-tyrosine. Group: Enzymes. Synonyms: kynurenine-glyoxylate aminotransferase. Enzyme Commission Number: EC 2.6.1.63. CAS No. 74506-33-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2904; kynurenine-glyoxylate transaminase; EC 2.6.1.63; 74506-33-5; kynurenine-glyoxylate aminotransferase. Cat No: EXWM-2904. | |
| Kynurenine Impurity 1 | Kynurenine Impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1022-31-7. Molecular formula: C10H10N2O4. Mole weight: 222.2. Catalog: APB1022317. |  |
| Kynurenine Impurity 5 | Kynurenine Impurity 5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 153152-32-0. Molecular formula: C10H11ClN2O3. Mole weight: 242.66. Catalog: APB153152320. | |
| kynurenine-oxoglutarate transaminase | A pyridoxal-phosphate protein. Also acts on 3-hydroxykynurenine. The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction. Group: Enzymes. Synonyms: kynurenine transaminase (cyclizing); kynurenine 2-oxoglutarate transaminase; kynurenine aminotransferase; L-kynurenine aminotransferase. Enzyme Commission Number: EC 2.6.1.7. CAS No. 9030-38-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2909; kynurenine-oxoglutarate transaminase; EC 2.6.1.7; 9030-38-0; kynurenine transaminase (cyclizing); kynurenine 2-oxoglutarate transaminase; kynurenine aminotransferase; L-kynurenine aminotransferase. Cat No: EXWM-2909. | |
| 3-Hydroxy-DL-kynurenine | 3-Hydroxy-DL-kynurenine is an active metabolite of tryptophan. Synonyms: Benzenebutanoic acid, α,2-diamino-3-hydroxy-γ-oxo-; Alanine, 3-(3-hydroxyanthraniloyl)-; α,2-Diamino-3-hydroxy-γ-oxobenzenebutanoic acid; 3-Hydroxykynurenine; DL-3-Hydroxykynurenine; Hydroxykynurenine. Grade: ≥98%. CAS No. 484-78-6. Molecular formula: C10H12N2O4. Mole weight: 224.21. |  |
| 3-Hydroxy-DL-kynurenine-(?,?,?-13C3,?-amino-15N) | ?98 atom %, ?95% (CP). Group: Fluorescence/luminescence spectroscopy. | |
| 3-Hydroxy-DL-kynurenine-[5,8,8-d3] | 3-Hydroxy-DL-kynurenine-[5,8,8-d3] is a labelled 3-hydroxy-DL-kynurenine. 3-hydroxy-DL-kynurenine is a byproduct of metabolism of tryptophan. Synonyms: 2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid-d3; 3-Hydroxykynurenine-5,5,8-d3. Grade: 95% by HPLC; 98% atom D. Molecular formula: C10H9D3N2O4. Mole weight: 227.24. | |
| 3-Hydroxykynurenine | 3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 3-Hydroxy-DL-kynurenine. CAS No. 484-78-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113294. |  |
| 4-Chloro Kynurenine-13C2,15N | 7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application. Group: Biochemicals. Alternative Names: α,2-Diamino-4-chloro-γ-oxobenzenebutanoic Acid-13C2,15N; (+/-)-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| D-Kynurenine | a metabolite of D-tryptophan that is also a bioprecursor of two neuroactive compounds kynurenic acid (KYNA) and 3-hydroxykynurenine. Synonyms: (αR)-α,2-Diamino-γ-oxo-benzenebutanoic Acid; D-3-Anthraniloylalanine; (R)-α,2-Diamino-γ-oxo-benzenebutanoic Acid. Grade: > 95%. CAS No. 13441-51-5. Molecular formula: C10H12N2O3. Mole weight: 208.22. | |
| DL-3-Hydroxy Kynurenine-1,2,3-13C3, alpha-amino-15N | DL-3-Hydroxy Kynurenine-1,2,3-13C3, alpha-amino-15N is a labelled derivative of Kynurenine. Kynurenine is a metabolite of tryptophan that is produced via tryptophan-kynurenine pathway. Grade: 95% by HPLC; 98% atom 13C, 98% atom 15N. Molecular formula: C7[13C]3H12N[15N]O4. Mole weight: 228.18. | |
| DL-Kynurenine | DL-Kynurenine. Group: Biochemicals. Alternative Names: a,2-Diamino-gamma-oxo. Grades: Highly Purified. CAS No. 343-65-7. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C10H12N2O3. US Biological Life Sciences. | Worldwide |
| Fmoc-L-Kynurenine | Fmoc-L-Kynurenine. Synonyms: Fmoc-Asp(Ph(2-NH2))-OH. CAS No. 831210-89-0. Molecular formula: C25H22N2O5. Mole weight: 430.5. | |
| KMO Inhibitor I, Ro 61-8048 (Kynurenine-3-Monooxygenase Inhibitor I, Ro 61-8048 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide Dimethoxy-nitrophenyl-thiazolyl-benzenesulfonamide, Kynurenine-3-Hydroxylase Inhibitor I, Ro 61-8048) | A cell-permeable thiazolyl Benzene sulfonamide compound that acts as a potent, competitive and reversible inhibitor of kynurenine-3-monooxygenase activity (Ki=4.8nM; IC50=37nM). Reported to increase the circulating levels of kynurenic acid (KYNA), an excitatory amino acid receptors antagonist, lower reactive oxygen species [ROS], reduce neuronal loss and enhance the survival rate in several neuronal disease models. An orally bioavilable KMO Inhibitor II, JM6, a prodrug of Ro 61-8048 is also available. Group: Biochemicals. Grades: Highly Purified. CAS No. 199666-03-0. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S?, Molecular Weight: 421.5. US Biological Life Sciences. | Worldwide |
| L-Kynurenine | L-Kynurenine. Group: Biochemicals. Grades: Highly Purified. CAS No. 2922-83-0. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. US Biological Life Sciences. | Worldwide |
| L-Kynurenine | L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist. Uses: Scientific research. Group: Natural products. CAS No. 2922-83-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-104026. | |
| L-Kynurenine-[13C4,15N] | L-Kynurenine-[13C4,15N] is a labelled L-kynurenine. L-Kynurenine Sulfate is a tryptophan metabolite which is a precursor of kynurenic acid and an antagonist of N-methyl-aspartate receptor. Synonyms: L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid-13C4,15N; L-Kynurenine-13C4,15N. Grade: 95% by HPLC; 98% atom 13C, 98% atom 15N. Molecular formula: C6[13C]4H12N[15N]O3. Mole weight: 213.17. | |
| L-Kynurenine 98+% | L-Kynurenine 98+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g, 5g. US Biological Life Sciences. | Worldwide |
| L-Kynurenine-d4 | L-Kynurenine-d4 is the deuterium labeled L-Kynurenine. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 2672568-86-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-104026S. | |
| L-Kynurenine-[d4] | L-Kynurenine-[d4] is an isotopic analogue form of L-Kynurenine which is a product of constitutive tryptophan catabolism via tryptophan-2,3-dioxygenase in the liver and human gliomas and it is associated with the suppression of antitumor immune responses. Synonyms: L-Kynurenine-d4 [4-(2-aminophenyl-3,5-d2); 3,3-d2]; (S)-2-amino-4-(2-aminophenyl)-4-oxobutanoicacid-D4. Grade: 98% by HPLC; 98% atom D. Molecular formula: C10H8D4N2O3. Mole weight: 212.24. | |
| L-Kynurenine (Standard) | L-Kynurenine (Standard) is the analytical standard of L-Kynurenine. This product is intended for research and analytical applications. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist. Uses: Scientific research. Group: Natural products. CAS No. 2922-83-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104026R. | |
| rac α-Methyl Kynurenine | rac α-Methyl Kynurenine is an impurity of rac Kyurenine (K661000), a tryptophan metabolite and the precursor of an antagonist of N-methyl-aspartate receptor, Kynurenic acid (K660500). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| rac Kynurenine | A tryptophan metabolite, is a precursor of kynurenic acid, which is an antagonist of N-methyl-aspartate receptor. Group: Biochemicals. Alternative Names: α,2-Diamino-γ-oxo. Grades: Highly Purified. CAS No. 343-65-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 1-[2-Nitro-3- (phenylmethoxy) phenyl]ethanone | 1-[2-Nitro-3- (phenylmethoxy) phenyl]ethanone is an UV degradation product of 3-Hydroxy Kynurenine (H943695), a metabolite of tryptophan. Group: Biochemicals. Grades: Highly Purified. CAS No. 224044-60-4. Pack Sizes: 10mg, 50mg. Molecular Formula: C15H13NO4. US Biological Life Sciences. | Worldwide |
| 2-Acetamido-2-(2-(2-amino-3-hydroxyphenyl)-2-oxoethyl)malonic Acid Diethyl Ester | 2-Acetamido-2-(2-(2-amino-3-hydroxyphenyl)-2-oxoethyl)malonic Acid Diethyl Ester is an UV degradation product of 3-Hydroxy Kynurenine (H943695), a metabolite of tryptophan. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 25mg. Molecular Formula: C17H22N2O7. US Biological Life Sciences. | Worldwide |
| 2-(Acetylamino)-2-[2-[2-nitro-3-(phenylmethoxy)phenyl]-2-oxoethyl]propanedioic Acid 1,3-Diethyl Ester | 2-(Acetylamino)-2-[2-[2-nitro-3-(phenylmethoxy)phenyl]-2-oxoethyl]propanedioic Acid 1,3-Diethyl Ester is an UV degradation product of 3-Hydroxy Kynurenine (H943695), a metabolite of tryptophan. Group: Biochemicals. Grades: Highly Purified. CAS No. 224044-62-6. Pack Sizes: 5mg, 25mg. Molecular Formula: C24H26N2O9. US Biological Life Sciences. | Worldwide |
| 2-Amino-3-hydroxybenzoate Potassium Salt | 2-Amino-3-hydroxybenzoate Potassium Salt is an intermediate used in the synthesis of 3-Hydroxyanthranillic Acid-d3 (H801792), which is the labeled analogue of 3-Hydroxyanthranillic Acid, one of the tryptophan metabolites along with the kynurenine pathways. 3-Hydroxyanthranilic Acid has been shown to induce apoptosis in T cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C7H6KNO3, Molecular Weight: 191.23. US Biological Life Sciences. | Worldwide |
| 2-Amino-5-bromo-3-hydroxybenzoic Acid | 2-Amino-5-bromo-3-hydroxybenzoic Acid is an intermediate used in the synthesis of 3-Hydroxyanthranillic Acid-d3 (H801792), which is the labeled analogue of 3-Hydroxyanthranilic Acid, one of the tryptophan metabolites along the kynurenine pathway. 3-Hydroxyanthranilic Acid has been shown to induce apoptosis in T cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C7H6BrNO3, Molecular Weight: 232.03. US Biological Life Sciences. | Worldwide |
| 2-Bromo-1-[2-nitro-3- (phenylmethoxy) phenyl]ethanone | 2-Bromo-1-[2-nitro-3- (phenylmethoxy) phenyl]ethanone is an UV degradation product of 3-Hydroxy Kynurenine (H943695), a metabolite of tryptophan. Group: Biochemicals. Grades: Highly Purified. CAS No. 224044-61-5. Pack Sizes: 10mg, 25mg. Molecular Formula: C15H12BrNO4. US Biological Life Sciences. | Worldwide |
| 2-(Bromomethyl)-1-chloro-3-nitrobenzene | 2-(Bromomethyl)-1-chloro-3-nitrobenzene is a reactant in the synthesis of cyclic hydroxamic acid PF-04859989, a potent and selective inhibitor of human and rat Kynurenine aminotransferase II (KAT II) for treatment of schizophrenia. Group: Biochemicals. Grades: Highly Purified. CAS No. 56433-01-3. Pack Sizes: 100mg, 1g. Molecular Formula: C7H5BrClNO2, Molecular Weight: 250.48. US Biological Life Sciences. | Worldwide |
| 3-Hydroxyanthranilic acid | 3-Hydroxyanthranilic acid is a tryptophan metabolite in the kynurenine pathway.3-hydroxyanthranilic acid has anti-inflammatory, neuroprotective, and lipid-lowering effects. 3-hydroxyanthranilic acid can be used for researches of cardiovascular diseases, tumors, and metabolic diseases [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. CAS No. 548-93-6. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-W001171. | |
| 3-Hydroxyanthranilic Acid | 3-Hydroxy anthranilic acid is an intermediate in the oxidative metabolism of tryptophan in the kynurenine pathway that demonstrates immunoprotective effects. Uses: Free radical scavengers. Synonyms: 2-amino-3-hydroxybenzoic acid; 2-amino-3-hydroxybenzoic acid. Grade: ≥ 98 %. CAS No. 548-93-6. Molecular formula: C7H7NO3. Mole weight: 153.14. | |
| 3-Hydroxyanthranilic acid-[4,6-d2] | 3-Hydroxyanthranilic acid-[4,6-d2] is the labelled analogue of 3-Hydroxy anthranilic acid. 3-Hydroxy anthranilic acid is an intermediate in the oxidative metabolism of tryptophan in the kynurenine pathway that demonstrates immunoprotective effects. Synonyms: 2-Amino-3-hydroxybenzoic acid-4,6-d2; 3-Oxyanthranilic acid-4,6-d2. Grade: 98% by HPLC; 98% atom D. Molecular formula: C7H5D2NO3. Mole weight: 155.15. | |
| aromatic-amino-acid-glyoxylate transaminase | Phenylalanine, kynurenine, tyrosine and histidine can act as amino donors; glyoxylate, pyruvate and hydroxypyruvate can act as amino acceptors. Group: Enzymes. Enzyme Commission Number: EC 2.6.1.60. CAS No. 67185-76-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2902; aromatic-amino-acid-glyoxylate transaminase; EC 2.6.1.60; 67185-76-6. Cat No: EXWM-2902. | |
| arylformamidase | Also acts on other aromatic formylamines. Group: Enzymes. Synonyms: kynurenine formamidase; formylase; formylkynureninase; formylkynurenine formamidase; formamidase I; formamidase II. Enzyme Commission Number: EC 3.5.1.9. CAS No. 156229-75-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4481; arylformamidase; EC 3.5.1.9; 156229-75-3; kynurenine formamidase; formylase; formylkynureninase; formylkynurenine formamidase; formamidase I; formamidase II. Cat No: EXWM-4481. | |
| BFF 122 | BFF 122 is a potent and selective inhibitor of kynurenine aminotransferase II (IC50 = 1 μM and >30 μM for KAT II and KAT I respectively). Synonyms: BFF122; BFF 122; BFF-122; BF5; (S)-9-(4-Amino-piperazin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid. Grade: 99%. CAS No. 1152314-49-2. Molecular formula: C17H19FN4O4. Mole weight: 362.36. | |
| Cannflavin A | Cannflavin A can be isolated from Cannabis sativa L. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase ( KMO ). Cannflavin A activates apoptosis via caspase-3 cleavage [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 76735-57-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W748591. | |
| Cinnabarinic acid | Cinnabarinic acid is a kynurenine pathway metabolite of tryptophan and is produced by the oxidation of 3-Hydroxyanthranilic acid. It is a metabotropic glutamate receptor (mGlu4R-specific) agonist. It activates mGlu4 receptors in transiently transfected HEK293 cells and is selective over all other mGlu subtypes. It decreases cAMP levels in native cultured cerebellar granule cells. It may be used in studies of the functions of components of the kynurenine metabolic pathway. It leads to loss of apoptosis and mitochondrial respiration. It induces apoptosis in thymocytes by the generation of reactive oxygen species. It also counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells. It has neuroprotective activity. Synonyms: 2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid. Grade: ≥98% by HPLC. CAS No. 606-59-7. Molecular formula: C14H8N2O6. Mole weight: 300.22. | |
| Cinnabarinic acid | Cinnabarinic acid is a specific orthosteric agonist of mGlu 4 by interacting with residues of the glutamate binding pocket of mGlu4, has no activity at other mGlu receptors. Cinnabarinic acid is an endogenous metabolite of the kynurenine pathway of tryptophan. Cinnabarinic acid induces cell apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 606-59-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W011417. | |
| Indoleamine 2,3-dioxygenase 1 (199-207) | Indoleamine 2,3-dioxygenase 1 (199-207) is amino acids 199 to 207 fragment of Indoleamine 2,3-dioxygenase 1. IDO1 is a member of a unique class of mammalian haem dioxygenases that catalyse the oxidative catabolism of the least-abundant essential amino acid, L-Trp (L-tryptophan), along the kynurenine pathway. Synonyms: IDO1 (199-207). | |
| kynureninase | A pyridoxal-phosphate protein. Also acts on 3'-hydroxy-L-kynurenine and some other (3-arylcarbonyl)-alanines. Group: Enzymes. Enzyme Commission Number: EC 3.7.1.3. CAS No. 9024-78-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4732; kynureninase; EC 3.7.1.3; 9024-78-6. Cat No: EXWM-4732. | |
| LM10 | LM10 is a potent inhibitor of tryptophan 2,3-dioxygenase ( TDO ). Tryptophan 2,3-dioxygenase (TDO) is an unrelated hepatic enzyme that also degrades tryptophan along the kynurenine pathway. LM10 has the potential for the research of cancer diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1316695-35-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-33298. | |
| PF-04859989 hydrochloride | PF-04859989 hydrochloride is a brain-penetrant, irreversible kynurenine aminotransferase (KAT) II inhibitor with IC 50 s of 23 and 263 nM for hKAT II and rKAT II. PF-04859989 hydrochloride is selective for KAT II over human KAT I, KAT III, and KAT IV (IC50s of 22, 11, and >50 μM, respectively) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 177943-33-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116451. | |
| Quinolinic acid | Quinolinic acid is an endogenous N-methyl-D-aspartate ( NMDA ) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 89-00-9. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 10 g. Product ID: HY-100807. | |
| Quinolinic acid-d3 | Quinolinic acid-d3 is the deuterium labeled Quinolinic acid. Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 138946-42-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-100807S. | |
| Ro 61-8048 | Ro 61-8048 is an orally active and selective inhibitor of kynurenine 3-hydroxylase, with an IC50 of 37 nM. Ro 61-8048 provokes a significant increase of extracellular kynurenic acid concentrations[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 199666-03-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-12347. | |
| Superoxide Dismutase from Bovine, Recombinant | Superoxide dismutase (SOD) catalyzes the dismutation of superoxide radicals to hydrogen peroxide and molecular oxygen. SOD plays a critical role in the defense of cells against the toxic effects of oxygen radicals. SOD competes with nitric oxide (NO) for superoxide anion (which reacts with NO to form peroxynitrite), thereby SOD promotes the activity of NO. SOD has also been shown to suppress apoptosis in cultured rat ovarian follicles, neural cell lines, and transgenic mice by preventing the conversion of NO to peroxynitrate, an inducer of apoptosis. Sod from bovine erythr ocytes was the first sod to be found in mammalian tissues. before its enzymatic activity was disc...Superoxide dismutase has been used in a study to investigate where lipoproteins may affect the l-arginine-nitric oxide pathway. superoxide dismutase has also been used in a study to investigate the mass spectral evidence for carbonate-anion-radical-induced posttranslational modification of tryptophan to kynurenine in human cu, zn superoxide dismutase. the product has been used to develop an sod assay. this assay used dismutase-mediated inhibition of nadh-dependent nitroblue tetrazolium reduction. Group: Enzymes. Synonyms: Superoxide dismutases; EC 1.15.1.1; superoxidase dismutase; copper-zinc superoxide dismutase; Cu-Zn superoxide dismutase; ferrisuperoxide dismutase; s | |
| tryptophan 2,3-dioxygenase | A protohemoprotein. In mammals, the enzyme appears to be located only in the liver. This enzyme, together with EC 1.13.11.52, indoleamine 2,3-dioxygenase, catalyses the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism. The enzyme is specific for tryptophan as substrate, but is far more active with L-tryptophan than with D-tryptophan. Group: Enzymes. Synonyms: tryptophan pyrrolase (ambiguous); tryptophanase; tryptophan oxygenase; tryptamine 2,3-dioxygenase; tryptophan peroxidase; indoleamine 2,3-dioxygenase (ambiguous); indolamine 2,3-dioxygenase (ambiguous); L-tryptophan pyrrolase; TDO; L-tryptophan 2,3-dioxygenase; L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing). Enzyme Commission Number: EC 1.13.11.11. CAS No. 9014-51-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0531; tryptophan 2,3-dioxygenase; EC 1.13.11.11; 9014-51-1; tryptophan pyrrolase (ambiguous); tryptophanase; tryptophan oxygenase; tryptamine 2,3-dioxygenase; tryptophan peroxidase; indoleamine 2,3-dioxygenase (ambiguous); indolamine 2,3-dioxygenase (ambiguous); L-tryptophan pyrrolase; TDO; L-tryptophan 2,3-dioxygenase; L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing). Cat No: EXWM-0531. | |
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