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N-(2,4-Dinitro-5-fluorophenyl)-L-valinamide. Group: Biochemicals. Alternative Names: (2S)-2-[(5-Fluoro-2,4-dinitrophenyl)amino]-3-methylbutanamide; (S)-2-[(5-Fluoro-2,4-dinitrophenyl)amino]-3-methylbutanamide; N-(5-Fluoro-2,4-dinitrophenyl)-L-valinamide. Grades: Highly Purified. CAS No. 132679-61-9. Pack Sizes: 250mg. Molecular Formula: C11H13FN4O5, Molecular Weight: 300.24. US Biological Life Sciences.
Worldwide
Ac-DEVD-CHO
Ac-DEVD-CHO is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2. Uses: Cysteine proteinase inhibitors. Synonyms: N-acetyl-asp-glu-val-asp-al; Ac-Asp-Glu-Val-Asp-Aldehyde; L-Valinamide,N-acetyl-L-a-aspartyl-L-a-glutamyl-N-(2-carboxy-1-formylethyl)-. Grades: 95 %. CAS No. 169332-60-9. Molecular formula: C20H30N4O11. Mole weight: 502.47.
Ac-DEVD-CHO acetate
Ac-DEVD-CHO acetate is a specific inhibitor of Caspase-3. Synonyms: Caspase-3 Inhibitor I; N-acetyl-asp-glu-val-asp-al acetate; Ac-Asp-Glu-Val-Asp-al acetate; Ac-DEVD-al.CH3CO2H; L 761191 acetate; MF 191 acetate; N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-L-valyl-L-aspart-1-al acetate; N-Acetyl-L-α-aspartyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-L-valinamide acetate. Grades: ≥95%. Molecular formula: C22H34N4O13. Mole weight: 562.52.
Ac-DEVD-CMK
Ac-DEVD-CMK is a cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, -7, -8, and -10. It is commonly used at concentrations up to 100 μM to examine the role of caspase-3-dependent apoptosis in biological systems. Synonyms: Ac-Asp-Glu-Val-Asp-chloromethylketone; Caspase-3 Inhibitor III; N-acetyl-Asp-Glu-Val-Asp-chloromethylketone; N-Acetyl-L-α-aspartyl-L-α-glutamyl-N-[(2S)-1-carboxy-4-chloro-3-oxo-2-butanyl]-L-valinamide; (2S,5S,8S,11S)-8-(2-carboxyethyl)-11-(carboxymethyl)-2-(2-chloroacetyl)-5-isopropyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazatetradecane-1-carboxylic acid. Grades: ≥98%. CAS No. 285570-60-7. Molecular formula: C21H31ClN4O11. Mole weight: 550.95.
Adrenorphin
Adrenorphin is an opioid octapeptide that acts as an agonist of μ-opioid receptor. Synonyms: L-Valinamide, L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-; L-Tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-L-valinamide; Adrenorphin (human); Adrenorphin (ox); BAM 8; Metaphinamide; Metorphamide; Metorphamide (ox); Metorphinamide; H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2. Grades: >95%. CAS No. 88377-68-8. Molecular formula: C44H69N15O9S. Mole weight: 984.18.
Antipain
Antipain, a protease inhibitor isolated from Actinomycetes, inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberration. It restricts DNA synthesis and function of mice uterus. Uses: Protease inhibitors. Synonyms: [(S)-1-Carboxy-2-phenylethyl]carbamoyl-L-arginyl-L-valyl-argininal; L-valinamide, N2-[[((1S)-1-carboxy-2-phenylethyl)amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-; Phe-CO-Arg-Val-L-Arg-H; N2-{[(1S)-1-Carboxy-2-phenylethyl]carbamoyl}-N5-(diaminomethylene)-L-ornithyl-N-{5-[(diaminomethylene)amino]-1-oxo-2-pentanyl}-L-valinamide. Grades: 95%. CAS No. 37691-11-5. Molecular formula: C27H44N10O6. Mole weight: 604.70.
Antipain dihydrochloride
Antipain dihydrochloride, a protease inhibitor isolated from Actinomycetes, inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberration. It restricts DNA synthesis and function of mice uterus. Synonyms: Antipain dihydrochloride from microbial source; N-(Nα-Carbonyl-Arg-Val-Arg-al)-Phe; N2-[((1S)-1-Carboxy-2-phenylethyl)carbamoyl]-N5-(diaminomethylene)-L-ornithyl-N-{5-[(diaminomethylene)amino]-1-oxo-2-pentanyl}-L-valinamide dihydrochloride; L-valinamide, N2-[[((1S)-1-carboxy-2-phenylethyl)amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-, hydrochloride (1:2). Grades: ≥95%. CAS No. 37682-72-7. Molecular formula: C27H44N10O6.2HCl. Mole weight: 677.62.
Auristatin F
Auristatin F, a synthetic analog of dolastatin 10, is a cytotoxic tubulin modifier with potent and selective antitumor activity. It is an MMAF analog and cytotoxin in Antibody-drug conjugates. Uses: Adcs cytotoxin. Synonyms: N,N-Dimethyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-L-phenylalanine; L-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-; N,N-Dimethyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl}-3-methoxy-5-methyl-1-oxo-4-heptanyl]-N-methyl-L-valinamide. Grades: ≥97% by HPLC. CAS No. 163768-50-1. Molecular formula: C40H67N5O8. Mole weight: 745.99.
Cephabacin M6
It is produced by the strain of Lysobacter lactamgenus YK-90, Xanthomonas lactamgena YK-278?YK-280 and YK-431. It has anti-gram positive and negative bacterial activity. The Cephabacin M series is stable and has inhibitory effect on cephalosporin enzyme. Synonyms: Cephabacin M(sub 6); L-Valinamide, L-alanyl-L-seryl-L-ornithyl-L-valyl-L-ornithyl-N-(4-((7-((5-amino-5-carboxyl-1-oxopentyl)amino)-2-carboxy-7-methoxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-3-en-3-yl)methoxy)-1-(2-amino-2-oxoethyl)-2-hydroxy-4-oxobutyl)-, (6R-(6-alpha,7-alpha,7(R*)))-; Cephabacin M6; LS-161269. CAS No. 99313-73-2. Molecular formula: C47H79N13O18S. Mole weight: 1146.27.
Dolastatin 10
Dolastatin 10 is a potent antimitotic peptide from a marine animal, strongly inhibiting microtubule assembly. Uses: Adcs cytotoxin. Synonyms: DLS 10; NSC 376128; Dolastatin-10; DLS-10; DLS10; NSC376128; NSC-376128; L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1-methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-,[2S-[1[1R*(R*),2S*],2R*[1S*,2S*,3(R*)]]]-. Grades: >98%. CAS No. 110417-88-4. Molecular formula: C42H68N6O6S. Mole weight: 785.09.
Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a cell-permeable and non-toxic inhibitor that binds irreversibly to activated caspase-3 in apoptotic cells. Synonyms: 6-FAM-D(OMe)E(OMe)VD(OMe)-FMK; L-Valinamide, N-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-6-yl)carbonyl]-L-α-aspartyl-L-α-glutamyl-N-[1-(2-fluoroacetyl)-3-methoxy-3-oxopropyl]-, 1,2-dimethyl ester; Methyl (8S,11S,14S)-14-{[(3',6'-dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthen]-6-yl)carbonyl]amino}-5-(fluoroacetyl)-8-isopropyl-11-(3-methoxy-3-oxopropyl)-3,7,10,13-tetraoxo-2-oxa-6,9,12-triazahexadecan-16-oate. Grades: ≥95%. CAS No. 1926163-65-6. Molecular formula: C43H45FN4O16. Mole weight: 892.83.
Fmoc-3VVD-OH
Fmoc-3VVD-OH is a cleavable ADC linker used to synthesize antibody-drug conjugations (ADCs). Synonyms: (5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-methoxy-4,10-dimethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(2R,3S,4S)-1-carboxy-2-methoxy-4-methyl-3-hexanyl]-N-methyl-L-valinamide; L-Valinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(1S,2S)-1-[(1R)-2-carboxy-1-methoxyethyl]-2-methylbutyl]-N-methyl-; FMOC-3AA-OH. Grades: ≥95%. CAS No. 863971-44-2. Molecular formula: C36H51N3O7. Mole weight: 637.81.
GE20372 A
GE20372 A, a tetrapeptide, is produced by the strain of Streptomyces sp. It is used as a human immunodeficiency virus (HIV-L) protease inhibitor. Synonyms: GE20372 Factor A; GE-20372A; (1(S),2(S))-N2-(((1-Carboxy-2-(4-hydroxyphenyl)ethyl)amino)carbonyl)-L-arginyl-N-(1-formyl-2-phenylethyl)-L-valinamide. CAS No. 163565-75-1. Molecular formula: C30H41N7O7. Mole weight: 611.69.
L-Valine Amide is a reagent used in the synthesis of alkylpyrazines. Also used in the synthesis of elastase inhibitory activity. Synonyms: L-Val-NH2 HCl; (2S)-2-amino-3-methylbutanamide hydrochloride; H-Val-NH2 HCl; L-Valinamide Hydrochloride. Grades: ≥ 99% (HPLC). CAS No. 3014-80-0. Molecular formula: C5H12N2O·HCl. Mole weight: 152.60.
MeoSuc-Ala-Ala-Pro-Val-AMC
MeOSuc-AAPV-AMC is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase. The methoxy succinyl (MeO-Suc) peptide AAPV is hydrolyzed by these elastases but not by cathepsin G. The addition of 7-amino-4-methylcoumarin (AMC) generates a peptide of low fluorescence (excitation: 355-380 nm; emission 440-460 nm) that demonstrates a linear increase in fluorescence intensity in the presence of elastase. Synonyms: MeOSuc-AAPV-AMC;I 1270; Methoxy Succinyl-Ala-Ala-Pro-Val-AMC; N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-valinamide. Grades: ≥95% by HPLC. CAS No. 72252-90-5. Molecular formula: C31H41N5O9. Mole weight: 627.7.
MMAF Hydrochloride
MMAF Hydrochloride, a synthetic antineoplastic agent, is a tubulin polymerization inhibitor that inhibits cell division by blocking the polymerization of tubulin. It is part of some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A. Uses: Adcs cytotoxin. Synonyms: Monomethylauristatin F Hydrochloride; Monomethyl Auristatin F Hydrochloride; N-Methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-L-phenylalanine Hydrochloride; Monomethylauristatin Phenylalanine Hydrochloride; L-Valinamide, N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-, Hydrochloride (1:1); ((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalanine Hydrochloride. Grades: >98%. CAS No. 1415246-68-2. Molecular formula: C39H66ClN5O8. Mole weight: 768.42.
Pep-1-Cysteamine
Pep-1 is a synthetic cell-penetrating peptide (CPP) that has been successfully used to deliver a variety of proteins and other biopharmaceutical macromolecules into cells in a non-disruptive manner. It is a CPP with primary amphipathicity that comprises a tryptophan-rich so-called "hydrophobic" domain, a hydrophilic domain derived from an NLS (nuclear localization signal) of SV40 (simian virus 40) large T-antigen, and a spacer between them. The C-terminal cysteamine group appears to play a crucial role in the delivery efficiency of cargoes into cells. Synonyms: Ac-Lys-Glu-Thr-Trp-Trp-Glu-Thr-Trp-Trp-Thr-Glu-Trp-Ser-Gln-Pro-Lys-Lys-Lys-Arg-Lys-Val-cysteamine; L-Valinamide, N2-acetyl-L-lysyl-L-α-glutamyl-L-threonyl-L-tryptophyl-L-tryptophyl-L-α-glutamyl-L-threonyl-L-tryptophyl-L-tryptophyl-L-threonyl-L-α-glutamyl-L-tryptophyl-L-seryl-L-glutaminyl-L-prolyl-L-lysyl-L-lysyl-L-lysyl-L-arginyl-L-lysyl-N-(2-mercaptoethyl)-; N2-Acetyl-L-lysyl-L-α-glutamyl-L-threonyl-L-tryptophyl-L-tryptophyl-L-α-glutamyl-L-threonyl-L-tryptophyl-L-tryptophyl-L-threonyl-L-α-glutamyl-L-tryptophyl-L-seryl-L-glutaminyl-L-prolyl-L-lysyl-L-lysyl-L-lysyl-L-arginyl-L-lysyl-N-(2-sulfanylethyl)-L-valinamide. Grades: ≥95%. CAS No. 863608-35-9. Molecular formula: C140H202N36O33S. Mole weight: 2949.43.
Z-LVG-CHN2
Z-LVG-CHN2 is a tripeptide derivative that mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50 = 190 nM) via inhibition of SARS-COV-2 3CL pro protease. Synonyms: L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-(3-diazo-2-oxopropyl)-(9CI); Z-LVG-DMK. Grades: 95%. CAS No. 119670-30-3. Molecular formula: C22H31N5O5. Mole weight: 445.51.
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