Lactate Dehydrogenase Suppliers USA
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Product | Description | |
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Lactate Dehydrogenase A Inhibitor, FX11 (LDHA Inhibitor I, LDH-A Inhibitor I, LDH-M Inhibitor I, LDHM Inhibitor I) Quick inquiry Where to buy Suppliers range | A cell permeable, gossypol analog that acts as a selective, reversible, and NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8uM for human liver LDHA). Does not affect the activities of LDHB and glyceraldehyde-3-phosphate dehydrogenase even at higher concentrations. Shown to increase oxygen consumption, reactive oxygen species production, and cell death in P493 human lymphoma B cells. Also shown to reduce mitochondrial transmembrane potential and ATP levels and increase AMP kinase activity. Exhibits synergistic toxicity in P493 cells when combined with FK866. Blocks the progression of human lymphoma and pancreatic cancer xenografts and when used in combination with FK866 it induces lymphoma regression. Group: Biochemicals. Grades: Highly Purified. CAS No. 213971-34-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Lactate dehydrogenase isoenzyme 1 (LD1) Quick inquiry Where to buy Suppliers range | Lactate dehydrogenase isoenzyme 1 (LD1). Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. Catalog: APS009293. Format: Matrix Material. Shipping: Dry ice. | |
Lactate Dehydrogenase Isoenzyme 1 (LD1) (catalytic activity concentration) Quick inquiry Where to buy Suppliers range | Lactate Dehydrogenase Isoenzyme 1 (LD1) (catalytic activity concentration). Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. Catalog: APS009294. Shipping: Dry ice. | |
L-(+)-Lactate dehydrogenase Quick inquiry Where to buy Suppliers range | L-(+)-Lactate dehydrogenase. Group: Biochemicals. Grades: Highly Purified. CAS No. 9001-60-9. Pack Sizes: 1g, 2g, 5g, 10g, 25g. US Biological Life Sciences. | Worldwide |
L-lactate dehydrogenase A chain (254-265) Quick inquiry Where to buy Suppliers range | L-lactate dehydrogenase A chain. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-155. | |
1-Bromo-3,4-dimethoxy-2-propylbenzene Quick inquiry Where to buy Suppliers range | 1-Bromo-3,4-dimethoxy-2-propylbenzene is an intermediate formed in the synthesis of 2,3-Dihydroxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic Acid (D453265), which is used in the synthesis of novel lactate dehydrogenase A inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 142601-49-8. Pack Sizes: 100mg, 250mg. Molecular Formula: C11H15BrO2. US Biological Life Sciences. | Worldwide |
2,3-Dihydroxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic Acid Quick inquiry Where to buy Suppliers range | This compound is used in the synthesis of novel lactate dehydrogenase A inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 213971-34-7. Pack Sizes: 500ug, 5mg. Molecular Formula: C22H22O4. US Biological Life Sciences. | Worldwide |
2,3-Dihydroxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic Acid-d5 Quick inquiry Where to buy Suppliers range | 2,3-Dihydroxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic Acid-d5 is the labeled analogue of 2,3-Dihydroxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic Acid (D453265), used in the synthesis of novel lactate dehydrogenase A inhibitors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C22H17D5O4, Molecular Weight: 355.44. US Biological Life Sciences. | Worldwide |
2,3-Dimethoxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic Acid Quick inquiry Where to buy Suppliers range | 2,3-Dimethoxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic Acid is an intermediate formed in the synthesis of 2,3-Dihydroxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic Acid (D453265), which is used in the synthesis of novel lactate dehydrogenase A inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 213971-47-2. Pack Sizes: 5mg, 25mg. Molecular Formula: C24H26O4. US Biological Life Sciences. | Worldwide |
2,3-Dimethoxy-7-methyl-6-(phenylmethyl)-1-propylnaphthalene Quick inquiry Where to buy Suppliers range | 2,3-Dimethoxy-7-methyl-6-(phenylmethyl)-1-propylnaphthalene is an intermediate formed in the synthesis of 2,3-Dihydroxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic Acid, which is used in the synthesis of novel lactate dehydrogenase A inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 213971-42-7. Pack Sizes: 5mg, 25mg. Molecular Formula: C23H26O2. US Biological Life Sciences. | Worldwide |
2,4-Dichlorobenzeneboronic Acid Quick inquiry Where to buy Suppliers range | 2,4-Dichlorobenzeneboronic Acid is an intermediate used to prepare N-hydroxyindole-2-carboxylates for use as lactate dehydrogenase inhibitors and Non-ATP competitive MK2 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 68716-47-2. Pack Sizes: 1g, 5g. Molecular Formula: C6H5BCl2O2, Molecular Weight: 190.82. US Biological Life Sciences. | Worldwide |
2-Ketobutyric Acid Quick inquiry Where to buy Suppliers range | A substrate for the determination of lactate dehydrogenase isoenzymes.This compound is suitable for lactate dehydrogenase (LDH) related research. Group: Biochemicals. Alternative Names: 2-Oxobutanoic Acid; 2-Oxobutyric Acid; 2-Ketobutanoic Acid; 2-Ketobutyric Acid; 2-Oxo-n-butyric Acid; 2-Oxobutanoic Acid; 2-Oxobutyric Acid; 3-Methylpyruvic Acid; NSC 60533; Propionylformic Acid; α-Ketobutyric Acid; α-Oxo-n-butyric Acid; α-Oxobutanoic Acid; α-Oxobutyric Acid; α-keto-n-Butyric Acid. Grades: Reagent Grade. CAS No. 600-18-0. Pack Sizes: 5g, 10g, 25g. US Biological Life Sciences. | Worldwide |
3-Acetylpyridine Adenine Dinucleotide (APAD) Quick inquiry Where to buy Suppliers range | APAD is an NAD analog with higher oxidation potential than NAD. It can substitute for NAD as a hydrogen-accepting cofactor in many dehydrogenase reactions; e.g. lactate dehydrogenase from Toxoplasma, Clonorchis, and Plasmodium, bacterial lipoamide dehydrogenase, as well as mammalian dehydrogenases. It can also act as a proton acceptor in various transhydrogenation reactions with NADH or NADPH. Group: Biochemicals. Alternative Names: APAD; adenosine 5'-(trihydrogen diphosphate), P?5-ester with 3-acetyl-1- β -D-ribofuranosyl pyridinium , inner salt. Grades: Purified. CAS No. 86-08-8. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C22H28N6O14P2, Molecular Weight: 662.44. US Biological Life Sciences. | Worldwide |
Az-33 Quick inquiry Where to buy Suppliers range | Az-33 is a lactate dehydrogenase A (LDHA) inhibitor, which is a key enzyme in anaerobic glycolysis process and is deregulated in human malignancies. Uses: Az-33 is a lactate dehydrogenase a (ldha) inhibitor. Synonyms: Az 33; Az33; 2-(4-(4-((3-((2-Methylbenzo[d]thiazol-6-yl)amino)-3-oxopropyl)amino)-4-oxobutyl)benzyl)malonic acid. Grades: ≥98%. CAS No. 1370290-34-8. Molecular formula: C25H27N3O6S. Mole weight: 497.56. | |
Benzenebutanoic Acid Ethyl Ester Quick inquiry Where to buy Suppliers range | Benzenebutanoic Acid Ethyl Ester is used in the synthesis of thiazolium salts with potent antimalarial activity. Also used in the preparation of novel lactate dehydrogenase A inhibitors. Group: Biochemicals. Alternative Names: Ethyl 4-phenylbutanoate; Ethyl 4-phenylbutyrate; NSC 163318. Grades: Highly Purified. CAS No. 10031-93-3. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
Caspase-9 Inhibitor III Quick inquiry Where to buy Suppliers range | Caspase-9 Inhibitor III is a potent and irreversible inhibitor of caspase-9 with cardioprotective effects. Caspase inhibitors play an important role in investigating biological processes. Caspase-9 can reduce infarct size, lactate dehydrogenase (LDH) and creatine kinase (CK) release, and DNA smearing induced by ischemia and reperfusion in isolated rat hearts. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Synonyms: Ac-LEHD-CMK. Grades: 98%. CAS No. 403848-57-7. Molecular formula: C24H35ClN6O9. Mole weight: 587.02. | |
Danshensu Quick inquiry Where to buy Suppliers range | Danshensu is an active component of Salvia miltiorrhiza that shows wide cardiovascular benefit. It suppresses the formation of reactive oxygen species and inhibits platelet adhesion and aggregation. It also protects myocardium from the reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation. It increases production of collagenin Detroit 551 cells and attenuates the α-MSH-stimulated melanin production of B16 cells. It may be used as active ingredients in would healing, cosmetic treatments or treating hyperpigmentation. It significantly decreased the level of the marker enzymes (creatine kinase and lactate dehydrogenase) from the coronary effluents and myocardial infarction size in vitro. It also had ROS scavenging activity and boosted endogenous antioxidants such as SOD, CAT, MDA, GSH-PX and HO-1 activities by activating nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway which was mediated by Akt and ERK1/2 in western blot analysis. It significantly lowered tHcy in rats with elevated tHcy. Danshensu is a natural compound, which can also be used in cosmetics material. Synonyms: Benzenepropanoic acid, α,3,4-trihydroxy-, (αR)-; (αR)-α,3,4-Trihydroxybenzenepropanoic acid; Benzenepropanoic acid, α,3,4-trihydroxy-, (R)-; (R)-(+)-3-(3,4-Dihydroxyphenyl)lactic acid; (R)-3-(3,4-Dihydroxyphenyl)-2-hydroxypropionic acid; 3-(3',4'-Dihydroxyphenyl)-(2R)-lactic acid; D-(+)-β-(3,4-Dihydroxyphenyl)lactic acid; Dan Shen Su; Dan shen suan A; DS 182; Salianic acid A; Salvianic acid A; Tanshinol. Grades: >98%. CAS No. 76822-21-4. Molecular formula: C9H10O5. Mole weight: 198.17. | |
DCA Quick inquiry Where to buy Suppliers range | DCA is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. DCA also induces apoptosis and reverses the KV1.5 channels downregulation in cancer. Synonyms: Sodium dichloroacetate; Sodium 2,2-dichloroacetate; Dichloroacetic acid sodium salt. CAS No. 2156-56-1. Molecular formula: C2HCl2NaO2. Mole weight: 150.92. | |
Galloflavin Quick inquiry Where to buy Suppliers range | Galloflavin is a novel inhibitor of both the A and B isoforms of lactate dehydrogenase (Kis = 5.46 and 15.06 μM, respectively). It has also been shown to be a potential anticancer agent. Synonyms: NSC 107022; 3,8,9,10-tetrahydroxy-pyrano[3,2-c][2]benzopyran-2,6-dione. Grades: ≥98%. CAS No. 568-80-9. Molecular formula: C12H6O8. Mole weight: 278.2. | |
Galloflavin Potassium salt Quick inquiry Where to buy Suppliers range | Galloflavin Potassium salt is an inhibitor of human lactate dehydrogenase (LDH) (Ki = 5.46 and 15.1 μM for LDH-A and LDH-B, respectively, in competition with pyruvate) with anticancer activity. Galloflavin inhibits lactate production and decreases ATP synthesis in PLD/PRF/5 cells. Synonyms: NSC-107022 potassium; NSC 107022 potassium; NSC107022 potassium; 3,8,9,10-Tetrahydroxypyrano[3,2-c][2]benzopyran-2,6-dione potassium salt. Grades: ≥95% by HPLC. CAS No. 1780260-20-9. Molecular formula: C12H5O8K. Mole weight: 316.26. | |
Glycolic Acid-13C Sodium Salt Quick inquiry Where to buy Suppliers range | Glycolic Acid-13C Sodium Salt is the isotope labelled analog of Glycolic Acid Sodium Salt; a compound that increases the glycolate oxidase activity in the liver when fed to rats. It also increases the lactate dehydrogenase activity in the liver and kidney. Group: Biochemicals. Grades: Highly Purified. CAS No. 1706469-52-4. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C13CH3NaO3, Molecular Weight: 99.03. US Biological Life Sciences. | Worldwide |
GSK2837808A Quick inquiry Where to buy Suppliers range | GSK2837808A is a potent and specific lactate dehydrogenase A (LDHA) with IC50 values of 1.9 and 14 nM for LDHA and LDHB, respectively and inhibits lactate production in selected cancer cell lines. Synonyms: GSK2837808A; GSK-2837808A; GSK 2837808A; GSK2837808; GSK-2837808; GSK 2837808. 3-[[3-(cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino]-5-(3,5-difluorophenoxy)benzoic acid. CAS No. 1445879-21-9. Molecular formula: C31H25F2N5O7S. Mole weight: 649.62. | |
L-(+)-Lactic acid Quick inquiry Where to buy Suppliers range | L-(+)-Lactic acid is the only naturally occurring lactic acid in humans and mammals. Commercially, few bacteria like Lactobacillus casei, L. delbrueckii, Streptococcus lactis produces L-Lactic acid by fermentation process. Uses: Lactic acid has been used: as a component in substrate solution II for lactate dehydrogenase reaction as an additive in storage solution A as a supplement in the artificial gastric juice preparation for evaluation of degree of resistance Lactobacillus to the gastric stresses. Group: Acids. Alternative Names: (S)-2-Hydroxypropionic acid, Sarcolactic acid. CAS No. 79-33-4. Molecular Weight: 90.08. Molecular Formula: C3H6O3. SMILES: C[C@H](O)C(O)=O. | |
L+Lactic Acid, Calcium Salt, Pentahydrate Quick inquiry Where to buy Suppliers range | Lactic acid (2-hydroxypropanoic acid), also known as milk acid, is a chemical compound that plays a role in several biochemical processes. It was first isolated in 1780 by a Swedish chemist, Carl Wilhelm Scheele, and is a carboxylic acid with a chemical formula of C3H6O3. It has a hydroxyl group adjacent to the carboxyl group, making it an alpha hydroxy acid (AHA). In solution, it can lose a proton from the acidic group, producing the lactate ion CH3CH(OH)COO?. It is miscible with water or ethanol, and is hygroscopic. Lactic acid is chiral and has two optical isomers. One is known as L-(+)-lactic acid or (S)-lactic acid and the other, its mirror image, is D-(-)-lactic acid or (R)-lactic acid. L-(+)-Lactic acid is the biologically important isomer.In animals, L-lactate is constantly produced from pyruvate via the enzyme lactate dehydrogenase (LDH) in a process of fermentation during normal metabolism and exercise. It does not increase in concentration until the rate of lactate production exceeds the rate of lactate removal which is governed by a number of factors including: monocarboxylate transporters, concentration and isoform of LDH and oxidative capacity of tissues. The concentration of blood lactate is usually 1-2 mmol/L at rest, but can rise to over 20 mmol/L during intense exertion. Industrially, lactic acid fermentation is performed by Lactobacillus bacteria, among others. These bacteria can operate in the mouth; the acid they produce is responsible for the tooth decay known as caries.In medicine, lactate is one of the main components of Ringer's lactate or lactated Ringer's solution (Compound Sodium Lactate or Hartmann's Solution in the UK). This intravenous fluid consists of sodium and potassium cations, with lactate and chloride anions, in solution with distilled water in concentration so as to be isotonic compared to human blood. It is most commonly used for fluid resuscitation after blood loss due to trauma, surgery, or a burn injury. Group: Biochemicals. Alternative Names: Lactic Acid Calcium Salt (2:1) Pentahydrate; Propanoic Acid 2-Hydroxycalcium Salt Pentahydrate; Calcium Lactate Pentahydrate; Puracal DC. Grades: USP. CAS No. 5743-47-5. Pack Sizes: 100g, 250g, 500g, 1Kg, 2.5Kg. Molecular Formula: C6H10O6 Ca 5H2O, Molecular Weight: 308.29. US Biological Life Sciences. | Worldwide |
L-Lactic dehydrogenase Quick inquiry Where to buy Suppliers range | L-Lactic dehydrogenase. Uses: Used for research and manufacturing. Group: Food Ingredients. Alternative Names: IUB: 1.1.1.27;LACTIC DEHYDROGENASE;LACTIC DEHYDROGENASE BOVINE HEART;LACTIC ACID DEHYDROGENASE;LACTATE DEHYDROGENASE;LACTATE DEHYDROGENASE, HUMAN MUSCLE;LACTATE DEHYDROGENASE ISOENZYME-1, HUMAN;L-LACTATE DEHYDROGENASE. CAS No. 9001-60-9. Product ID: CDF4-0043. | |
Meldola Blue Quick inquiry Where to buy Suppliers range | A biosensor for the measurement of lactate in serum has been developed, which is based on a screen-printed carbon electrode, modified with Meldola's Blue-Reinecke Salt (MBRS-SPCE), coated with the enzyme lactate dehydrogenase NAD+ dependent (from Porcine heart), and NAD+. A cellulose acetate layer was deposited on the top of the device to act as a permselective membrane. Group: Biochemicals. Alternative Names: 9- (Dimethylamino) benzo[a]phenoxazin-7-ium Chloride Zinc Chloride; Meldola's Blue; Zinc Chloride 9- (Dimethylamino) benzo[a]phenoxazin-7-ium Chloride; Basic Leather Blue D; Meldola Blue. CAS No. 7057-57-0. Pack Sizes: 2.5mg. Molecular Formula: C??H??ClN?O xZnCl?. US Biological Life Sciences. | Worldwide |
Methyl 4-(Methylamino)benzoate Quick inquiry Where to buy Suppliers range | Methyl 4-(Methylamino)benzoate is used as a reagent in the synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5. Also used in the preparation of hyaluronic acid-methotrexate conjugates as antiarthritic and antiinflammatory agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 18358-63-9. Pack Sizes: 250mg, 500mg. Molecular Formula: C9H11NO2, Molecular Weight: 165.19. US Biological Life Sciences. | Worldwide |
mitoNEET Inhibitor NL-1, Thiazolidinedione (5-(3,5-di-tert-butyl-4-hydroxybenzyl)-4-hydroxythiazol-2(5H)-one) Quick inquiry Where to buy Suppliers range | A cell-permeable, thiazolidinedione (TZD) that acts as an inhibitor of MitoNEET (IC50=0.9uM) in competition with rosiglitazone and pioglitazone, in liver mitochondrial suspensions. In pharmacological studies, it was found to alter isolated mitochondrial complex I respiration with an IC50 of 2.4uM and inhibited State III respiration up to 45%. Furthermore, this compound (6-25uM) is shown to dose-dependently reduce lactate-dehydrogenase release in SH-SY5Y cultures, leading to a 40% decrease in rotenone-induced cell-death. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
NHI 2 Quick inquiry Where to buy Suppliers range | NHI-2 is a lactate dehydrogenase isoform inhibitor with IC50 value of 14.7 μM. It has anti-glycolytic activity against a variety of cancer cells. Synonyms: NHI-2; NHI 2; NHI2; Methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate. Grades: ≥98% by HPLC. CAS No. 1269802-97-2. Molecular formula: C17H12F3NO3. Mole weight: 335.28. | |
(R)-GNE-140 Quick inquiry Where to buy Suppliers range | (R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor (IC50s= 3 nM for LDHA and 5 nM for LDHB), with 18-fold more potent than S enantiomer. Synonyms: (2R)-5-(2-chlorophenyl)sulfanyl-4-hydroxy-2-(4-morpholin-4-ylphenyl)-2-thiophen-3-yl-1,3-dihydropyridin-6-one; GNE-140; GNE 140; GNE140. CAS No. 2003234-63-5. Molecular formula: C25H23ClN2O3S2. Mole weight: 499.04. | |
Sodium Oxamate Quick inquiry Where to buy Suppliers range | Sodium oxamate is an inhibitor of lactate dehydrogenase (LDH), a key regulator of glycolysis, reversibly catalyzing the conversion of pyruvate to lactate. Synonyms: Sodium 2-amino-2-oxoacetate; Oxamic acid sodium salt. Grades: ≥95%. CAS No. 565-73-1. Molecular formula: C2H2NO3·Na. Mole weight: 111. | |
Threonine Dehydrogenase Inhibitor, QC1 (N-Benzyl-4-oxo-2-thioxo-3- (3- (trifluoromethyl) phenyl) -1, 2, 3, 4-tetrahydroquinazoline-7-carboxamide) Quick inquiry Where to buy Suppliers range | A cell-permeable quinazolinecarboxamide (QC) compound that acts as a potent, reversible and mixed noncompetitive inhibitor of threonine dehydrogenase activity (IC50 ~ 0.5uM for mTDH) with excellent selectivity over hydroxysteroid, alcohol, lactate, or glucose-6-phosphate dehydrogenases (IC50 >10uM). Shown to block threonine catabolism, induce autophagy and impede the growth of highly proliferating mouse embryonic stem cells (mESCs; EC50 ~3uM) with no effect on ESCs-derived embryoid body cells, 3T3 fibroblasts or tumor cells (EC50 ~1 mM). Group: Biochemicals. Grades: Highly Purified. CAS No. 403718-45-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |