Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Lanosterol | ?93%, powder. Group: Fluorescence/luminescence spectroscopy. |  |
| Lanosterol | Lanosterol, an amphipathic molecule, that is produced by lanosterol synthase (LSS). It is enriched in the lens. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Lanosta-8,24-dien-3beta-ol. Appearance: White to light-yellow powder. CAS No. 79-63-0. Molecular formula: C30H50O. Mole weight: 426.72. Purity: 0.98. IUPACName: (3S,5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol. Canonical SMILES: C[C@H](CCC=C(C)C)[C@H]1CC[C@@]2([C@@]1(CCC3=C2CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)C)C. Density: 0.98g/cm³. ECNumber: 201-214-9. Product ID: ACM79630. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Lanosterol | Lanosterol Inhibitor. Uses: Scientific use. Product Category: T4970. CAS No. 79-63-0. |  |
| Lanosterol | Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol suppresses the aggregation and cytotoxicity of misfolded proteins linked with neurodegenerative diseases [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 79-63-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W020033. |  |
| Lanosterol | Lanosterol is a sterol cholesterol precursor found in Mushroom Inonotus obliquus. Synonyms: Lanosterin; Lanster; Botalan base 138; Lanosta-8,24-dienol. Grade: ≥93%. CAS No. 79-63-0. Molecular formula: C30H50O. Mole weight: 426.72. |  |
| Lanosterol | Lanosterol - Product ID: NST-10-82. Category: Triterpens. Alternative Names: Lanosta-8,24-dien-3?-ol. Purity: 98%. Test method: HPLC. CAS No. 79-63-0. Pack Sizes: 10g, 20g, 50g, 100g. Appearance: White to beige coloured Powder. Molecular formula: C30H50O. Mole weight: 426.73. Storage: +2 +8 °C. |  |
| Lanosterol-d6 | Lanosterol-d 6 is deuterium labeled Lanosterol. Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol s. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 28290-39-3. Pack Sizes: 100 μg; 1 mg. Product ID: HY-W020033S. | |
| lanosterol synthase | Lanosterol synthase is an oxidosqualene cyclase (OSC) enzyme that converts (S)-2,3-oxidosqualene to a protosterol cation and finally to lanosterol. Lanosterol is a key four-ringed intermediate in cholesterol biosynthesis. In humans, lanosterol synthase is encoded by the LSS gene. Group: Enzymes. Synonyms: 2,3-epoxysqualene lanosterol cyclase; squalene-2,3-oxide-lanosterol cyclase; lanosterol 2,3-oxidosqualene cyclase; squalene 2,3-epoxide:lanosterol cyclase; 2,3-oxidosqualene sterol cyclase; oxidosqualene cyclase; 2,3-oxidosqualene cyclase; 2,3-oxidosqualene-lanosterol cyclase; oxidosqualene-lanosterol cyclase; squalene epoxidase-cyclase; (S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming). Enzyme Commission Number: EC 5.4.99.7. CAS No. 9032-71-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5607; lanosterol synthase; EC 5.4.99.7; 9032-71-7; 2,3-epoxysqualene lanosterol cyclase; squalene-2,3-oxide-lanosterol cyclase; lanosterol 2,3-oxidosqualene cyclase; squalene 2,3-epoxide:lanosterol cyclase; 2,3-oxidosqualene sterol cyclase; oxidosqualene cyclase; 2,3-oxidosqualene cyclase; 2,3-oxidosqualene-lanosterol cyclase; oxidosqualene-lanosterol cyclase; squalene epoxidase-cyclase; (S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming). Cat No: EXWM-5607. |  |
| 1,1'-(((2R,2'R,4R,4'R)-4,4'-(oxybis(methylene))bis(2-(2,4-difluoro phenyl)tetrahydrofuran-4,2-diyl))bis(methylene))bis(1H-1,2,4-triazole) | 1,1'-(((2R,2'R,4R,4'R)-4,4'-(oxybis(methylene))bis(2-(2,4-difluoro phenyl)tetrahydrofuran-4,2-diyl))bis(methylene))bis(1H-1,2,4-triazole) is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. CAS No. 2256739-22-5. Molecular formula: C28H28F4N6O3. Mole weight: 572.56. | |
| 1-((2R,3R)-2-(benzyloxy)pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one | 1-((2R,3R)-2-(benzyloxy)pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. CAS No. 2243786-01-6. Molecular formula: C30H35N5O3. Mole weight: 513.64. | |
| 1-((2R,3S)-2-(benzyloxy)pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one | 1-((2R,3S)-2-(benzyloxy)pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. CAS No. 2243786-00-5. Molecular formula: C30H35N5O3. Mole weight: 513.64. | |
| 1-((2S,3R)-2-(benzyloxy)pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one | 1-((2S,3R)-2-(benzyloxy)pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. CAS No. 2243786-02-7. Molecular formula: C30H35N5O3. Mole weight: 513.64. | |
| 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine | 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. Synonyms: 4-[4-(4-Aminophenyl)-1-piperazinyl]phendiamineol; 4-[4-(4-aminophenyl)-1-piperazinyl]phenol. Grade: >95%. CAS No. 74853-08-0. Molecular formula: C16H19N3O. Mole weight: 269.34. | |
| 2-[(1S,2S)-1-Ethyl-2-bezyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one | Posaconazole Diastereoisomer Related Compound 6 is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. Uses: Intermediate in the preparation of posaconazole. Synonyms: Posaconazole Impurity 63; 2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one. Grade: >95%. CAS No. 184177-83-1. Molecular formula: C30H35N5O3. Mole weight: 513.63. | |
| 2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]-2,4-dihydro-4-[4-[4-(4-O-methoxymethyl-4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one | 2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]-2,4-dihydro-4-[4-[4-(4-O-methoxymethyl-4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. Synonyms: [S-(R*,R*)]-2-[1-Ethyl-2-(phenylmethoxy)propyl]-2,4-dihydro-4-[4-[4-(4-O-methoxymethyl-4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one. CAS No. 1246815-19-9. Molecular formula: C32H39N5O4. Mole weight: 557.68. | |
| (2R,4R)-rel-2,4-Bis(2',4'-difluorophenyl)-2,4-dihydroxypentane | (2R,4R)-rel-2,4-Bis(2',4'-difluorophenyl)-2,4-dihydroxypentane is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. Synonyms: (2R,4R)-rel-2,4-Bis(2',4'-difluorophenyl)-2,4-dihydroxypentane; (2R,4R)-2,4-bis(2,4-difluorophenyl)pentane-2,4-diol. CAS No. 1329616-28-5. Molecular formula: C17H16F4O2. Mole weight: 328.3. | |
| ((3R,5R)-5-(2,4-difluorophenyl)-5-(iodomethyl)tetrahydrofuran-3-yl)methanol | ((3R,5R)-5-(2,4-difluorophenyl)-5-(iodomethyl)tetrahydrofuran-3-yl)methanol is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. Synonyms: (3R-cis)-5-(2,4-difluorophenyl)tetrahydro-5-(iodomethyl)-3-furanmethanol. CAS No. 182210-71-5. Molecular formula: C12H13F2IO2. Mole weight: 354.14. | |
| ((3S,5R)-5-(2,4-difluorophenyl)-5-(iodomethyl)tetrahydrofuran-3-yl)methyl isobutyrate | ((3S,5R)-5-(2,4-difluorophenyl)-5-(iodomethyl)tetrahydrofuran-3-yl)methyl isobutyrate is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. Synonyms: [(3S,5R)-5-(2,4-Difluorophenyl)-5-(iodomethyl)tetrahydro-3-furanyl]methyl 2-methylpropionate. CAS No. 1042398-26-4. Molecular formula: C16H19F2IO3. Mole weight: 424.22. | |
| (3S,5S,2S,3R)-Posaconazole | (3S,5S,2S,3R)-Posaconazole is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. Synonyms: 4-(4-(4-(4-(((3S,5S)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluoro phenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3R)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one. CAS No. 2243785-98-8. Molecular formula: C37H42F2N8O4. Mole weight: 700.79. | |
| 4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)-1-benzyl-1-(4-(1-((2S,3R)-2-hydroxypentan-3-yl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)piperazin-1-ium | 4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)-1-benzyl-1-(4-(1-((2S,3R)-2-hydroxypentan-3-yl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)piperazin-1-ium is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. CAS No. 1819334-66-1. Molecular formula: C57H70F2N10O42. Mole weight: 997.25. | |
| 4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2R,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one | 4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2R,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. CAS No. 171228-51-6. Molecular formula: C37H42F2N8O4. Mole weight: 700.79. | |
| 4-(4-(4-(4-(((3R,5S)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluoro phenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2R,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one | 4-(4-(4-(4-(((3R,5S)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluoro phenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2R,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. CAS No. 1229428-91-4. Molecular formula: C37H42F2N8O4. Mole weight: 700.79. | |
| 4-(4-(4-(4-(((3R,5S)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluoro phenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one | 4-(4-(4-(4-(((3R,5S)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluoro phenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. CAS No. 2243785-96-6. Molecular formula: C37H42F2N8O4. Mole weight: 700.79. | |
| 4-(4-(4-(4-(((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluoro phenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2R,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one | 4-(4-(4-(4-(((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluoro phenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2R,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. CAS No. 213381-06-7. Molecular formula: C37H42F2N8O4. Mole weight: 700.79. | |
| 4-(4-(4-(4-(((3S,5S)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluoro phenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2R,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one | 4-(4-(4-(4-(((3S,5S)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluoro phenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2R,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. CAS No. 2243785-99-9. Molecular formula: C37H42F2N8O4. Mole weight: 700.79. | |
| 4-Desfluoro Posaconazole | 4-Desfluoro Posaconazole is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. Synonyms: Desfluoro Posaconazole. Grade: >95%. Molecular formula: C37H43FN8O4. Mole weight: 682.79. | |
| Benzyl (4-(4-(4-Hydroxyphenyl)piperazin-1-yl)phenyl)carbamate | Benzyl (4-(4-(4-Hydroxyphenyl)piperazin-1-yl)phenyl)carbamate is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. Synonyms: [4-[4-(4-Hydroxyphenyl)-1-piperazinyl]phenyl]carbamic Acid Phenylmethyl Ester. CAS No. 864685-20-1. Molecular formula: C24H25N3O3. Mole weight: 403.47. | |
| Δ24-sterol reductase | Acts on a range of steroids with a 24(25)-double bond, including lanosterol, desmosterol and zymosterol. Group: Enzymes. Synonyms: lanosterol Δ24-reductase. Enzyme Commission Number: EC 1.3.1.72. CAS No. 9033-57-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1341; Δ24-sterol reductase; EC 1.3.1.72; 9033-57-2; lanosterol Δ24-reductase. Cat No: EXWM-1341. | |
| Difenoconazole-d6 hydrochloride | Difenoconazole-d6 is intended for use as an internal standard for the quantification of difenoconazole. Difenoconazole is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death. At sub-LC50 concentrations, difenoconazole induces pericardial and yolk sac edema in zebrafish embryos, body blackening and slowed heart rate in larvae, and decreased body weight and length in adults. Grade: ≥99% deuterated forms (d1-d6). Molecular formula: C19H11D6Cl2N3O3·HCl. Mole weight: 448.76. | |
| Diniconazole | Diniconazole is a newly developed fungicide strongly inhibited lanosterol 14 alpha-demethylation catalyzed by a yeast cytochrome P-450. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Rac-diniconazole. CAS No. 83657-24-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B1948. | |
| Diniconazole | Diniconazol is a chemical compound belonging to chlorine group of conazole. It is used as a fungicide. It inhibited lanosterol 14 alpha-demethylation catalyzed by a yeast cytochrome P-450 strongly. Uses: Pesticide. Synonyms: (E)-(±)-β-[(2,4-Dichlorophenyl)methylene]-α-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol; (E)-1-(2,4-Dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)-1-penten-3-ol; (E)-β-[(2,4-Dichlorophenyl)methylene]-α-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol; Mixor; Nb 2; Rac-diniconazole; S 3308; S 3308-10; S 3308L; Spotless; Sumi; Sumi 8; Sumi 8-020FS; Sumi 8-12.5WP; XE 779; 1H-1,2,4-Triazole-1-ethanol, β-[(2,4-dichlorophenyl)methylene]-α-(1,1-dimethylethyl)-, (βE)-. Grade: ≥95%. CAS No. 83657-24-3. Molecular formula: C15H17Cl2N3O. Mole weight: 326.22. | |
| Efinaconazole | Efinaconazole is a triazole antifungal. It is approved for use in Canada and the USA as a 10% topical solution for the treatment of onychomycosis (fungal infection of the nail). Efinaconazole acts as a 14α-demethylase inhibitor. Efinaconazole inhibits fungal lanosterol 14α-demethylase involved in the biosynthesis of ergosterol, a constituent of fungal cell membranes. Efinaconazole has been shown to be active against isolates of the following microorganisms, both in vitro and in clinical infections. Efinaconazole exhibits in vitro minimum inhibitory concentrations (MICs) of 0.06 μg/mL or less against most ( ≥ 90%) isolates of the following microorganisms: Trichophyton rubrum; Trichophyton mentagrophytes. Synonyms: KP103; KP-103; KP 103; CTK5J2975; AGJ95634; KB145948; AGJ 95634; KB 145948; AGJ-95634; KB-145948; Efinaconazole; trade name: Jublia. Grade: >98%. CAS No. 164650-44-6. Molecular formula: C18H22F2N4O. Mole weight: 348.39. | |
| Efinaconazole | Efinaconazole is a triazole antifungal. It is approved for use in Canada and the USA as a 10% topical solution for the treatment of onychomycosis (fungal infection of the nail). Efinaconazole acts as a 14α-demethylase inhibitor. Efinaconazole inhibits fungal lanosterol 14α-demethylase involved in the biosynthesis of ergosterol, a constituent of fungal cell membranes. Efinaconazole has been shown to be active against isolates of the following microorganisms, both in vitro and in clinical infections. Efinaconazole exhibits in vitro minimum inhibitory concentrations (MICs) of 0.06 μg/mL or less against most ( ≥ 90%) isolates of the following microorganisms: Trichophyton rubrum; Trichophyton mentagrophytes. Uses: Designed for use in research and industrial production. Additional or Alternative Names: KP103; KP-103; KP 103; CTK5J2975; AGJ95634; KB145948; Efinaconazole; trade name: Jublia. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 164650-44-6. Molecular formula: C18H22F2N4O. Mole weight: 348.39. Purity: >98%. IUPACName: (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol. Canonical SMILES: C[C@@H](N1CCC(CC1)=C)[C@@](O)(C2=CC=C(F)C=C2F)CN3N=CN=C3. Product ID: ACM164650446. Alfa Chemistry ISO 9001:2015 Certified. | |
| Fluconazole | Fluconazole is a triazole antifungal agent that is effective against most Candida strains. Fluconazole is a fungal lanosterol 14 alpha-demethylase inhibitor used in the treatment and prevention of superficial and systemic fungal infections. Synonyms: UK 49858; UK49858; UK-49858; α-(2,4-Difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazol-1-ethanol; 1-(2,4-Difluorophenyl)-1,1-bis[(1H-1,2,4-triazol-1-yl)methyl]methanol; Biozolene; Diflucan; Difluconazole; Elazor; Fluconal; Flucostat; Flumycon; Flusol; Fluzon; Triflucan; Zoltec. Grade: >98%. CAS No. 86386-73-4. Molecular formula: C13H12F2N6O. Mole weight: 306.27. | |
| Ganoderic Acid A | Ganoderic acids are a class of closely related triterpenoids (derivatives from lanosterol) found in Ganoderma mushrooms. For thousands of years, the fruiting bodies of Ganoderma fungi have been used in traditional medicines in East Asia. Consequently, there have been efforts to identify the chemical constituents that may be responsible for the putative pharmacological effects. There are dozens of ganoderic acids that have been isolated and characterized, of which ganoderic acid A and ganoderic acid B are the most well characterized. Some ganoderic acids have been found to possess biological activities including hepatoprotection, anti-tumor effects, and 5-alpha reductase inhibition. (Source: http://en.wikipedia.org/wiki/Ganoderic_acid). Uses: Designed for use in research and industrial production. Additional or Alternative Names: (25R)-7β,15α-Dihydroxy-3,11,23-trioxo-5α-lanost-8-en-26-oic acid. Product Category: Others. Appearance: Powder. CAS No. 81907-62-2. Molecular formula: C30H42O7. Mole weight: 514.65. Purity: 0.98. IUPACName: (2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,11-dioxo-2,5,6,7,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoic acid. Canonical SMILES: C[C@H](CC(=O)C[C@@H](C)C(=O)O)[C@H]1C[C@@H]([C@@]2([C@@]1(CC(=O)C3=C2[C@H](C[C@@H]4[C@@]3(CCC(=O)C4(C)C)C)O)C)C)O. Density: 1.22 g/ml. Product ID: ACM81907622. Alfa Chemistry | |
| Itraconazole | Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC 50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase ( cytochrome P450 enzyme ), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein ( OSBP ) inhibitor [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: R51211. CAS No. 84625-61-6. Pack Sizes: 100 mg; 500 mg. Product ID: HY-17514. | |
| Itraconazole | Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3H-1,2,4-Triazol-3-one, 4-(4-(4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-;(+-)-1-sec-Butyl-4-(p-(4-(p-(((2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-one. Product Category: Inhibitors. Appearance: Off-white crystalline solid. CAS No. 84625-61-6. Molecular formula: C35H38Cl2N8O4. Mole weight: 705.63. Purity: 0.9981. Canonical SMILES: ClC1=C(C=CC(Cl)=C1)[C@@]2(O[C@@H](COC3=CC=C(N4CCN(C5=CC=C(N(C=NN6C(C)CC)C6=O)C=C5)CC4)C=C3)CO2)CN7C=NC=N7. Density: 1.4 g/cm³. ECNumber: 283-347-2. Product ID: ACM84625616. Alfa Chemistry ISO 9001:2015 Certified. | |
| Lanopylin A1 | It is produced by the strain of Streptomyces sp. K99-5041. It can inhibit recombinant human lanosterol synthase (EC 5.4.99.7) with IC50 of 15 μmol/L. Synonyms: 2-Methyl-3-[(E)-15-methylhexadecane-1-ylidene]-4,5-dihydro-3H-pyrrole. Molecular formula: C22H41N. Mole weight: 319.57. | |
| Lanopylin A2 | It is produced by the strain of Streptomyces sp. K99-5041. It can inhibit recombinant human lanosterol synthase (EC 5.4.99.7) with IC50 of 18 μmol/L. Molecular formula: C24H43N. Mole weight: 345.60. | |
| Lanopylin B1 | It is produced by the strain of Streptomyces sp. K99-5041. It can inhibit recombinant human lanosterol synthase (EC 5.4.99.7) with IC50 of 33 μmol/L. Synonyms: 2-Methyl-3-[(E)-heptadecane-1-ylidene]-4,5-dihydro-3H-pyrrole. Molecular formula: C22H41N. Mole weight: 319.57. | |
| Lanopylin B2 | It is produced by the strain of Streptomyces sp. K99-5041. It can inhibit recombinant human lanosterol synthase (EC 5.4.99.7) with IC50 of 41 μmol/L. Molecular formula: C24H43N. Mole weight: 345.60. | |
| methylsterol monooxygenase | Requires cytochrome b5. Also acts on 4α-methyl-5α-cholest-7-en-3β-ol. The sterol can be based on cycloartenol as well as lanosterol. Group: Enzymes. Synonyms: methylsterol hydroxylase; 4-methylsterol oxidase; 4,4-dimethyl-5α-cholest-7-en-3β-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating). Enzyme Commission Number: EC 1.14.13.72. CAS No. 37256-80-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0879; methylsterol monooxygenase; EC 1.14.13.72; 37256-80-7; methylsterol hydroxylase; 4-methylsterol oxidase; 4,4-dimethyl-5α-cholest-7-en-3β-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating). Cat No: EXWM-0879. | |
| MM0299 | MM0299 is an inhibitor for lanosterol synthase (LSS) with an IC50 of 2.2 ?M. MM0299 inhibits cell proliferation of Mut6 with an IC50 of 0.0182 ?M, through generation of 24(S),25-epoxycholesterol (EPC) and the depletion of cellular cholesterol[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 474255-10-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160972. | |
| Posaconazole | Anti-fungal agent; sterol α-demethylase inhibitor. Posaconazole is a highly potent broadspectrum antifungal drug. It blocks the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase resulting in accumulation of methylated sterol precursors. In contrast to other antifungal azoles, posaconazole has been reported not to induce the efflux pump mechanism. Posaconazole was able to produce a parasitological cure in a mouse model of the chronic stage of Chagas disease. Group: Biochemicals. Alternative Names: 2, 5-Anhydro-1, 3, 4-trideoxy-2-C- (2, 4-difluorophenyl) -4- [ [4- [4- [4- [1- [ (1S, 2S) -1-ethyl-2-hydroxypropyl] -1, 5-dihydro-5-oxo-4H-1, 2, 4-triazol-4-yl] phenyl] -1-piperazinyl] phenoxy] methyl] -1- (1H-1, 2, 4-triazol-1-yl) -D-threo-pentitol; Noxafil; Sch 56592. Grades: Highly Purified. CAS No. 171228-49-2. Pack Sizes: 250mg, 500mg, 1g, 5g. Molecular Formula: C??H??F?N?O?, Molecular Weight: 700.78. US Biological Life Sciences. |  Worldwide |
| (R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole | (R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. CAS No. 1370190-85-4. Molecular formula: C14H13F2N3O. Mole weight: 277.27. | |
| (S)-Luliconazole-Z-Isomer | (S)-Luliconazole-Z-Isomer is a potent pharmaceutical compound used in the research of fungal infections, specifically those caused by dermatophytes. It exhibits antifungal activity by inhibiting lanosterol 14α-demethylase is a key enzyme involved in ergosterol synthesis. Grade: > 95%. Molecular formula: C14H9Cl2N3S2. Mole weight: 354.28. | |
| squalene monooxygenase | A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7 lanosterol synthase, was formerly known as squalene oxidocyclase. The electron donor is EC 1.6.2.4, NADPH-hemoprotein reductase. Group: Enzymes. Synonyms: squalene epoxidase; squalene-2,3-epoxide cyclase; squalene 2,3-oxidocyclase; squalene hydroxylase; squalene oxydocyclase; squalene-2,3-epoxidase. Enzyme Commission Number: EC 1.14.14.17. CAS No. 9029-62-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0914; squalene monooxygenase; EC 1.14.14.17; 9029-62-3; squalene epoxidase; squalene-2,3-epoxide cyclase; squalene 2,3-oxidocyclase; squalene hydroxylase; squalene oxydocyclase; squalene-2,3-epoxidase. Cat No: EXWM-0914. | |
| sterol 14α-demethylase | This heme-thiolate (P-450) enzyme acts on a range of steroids with a 14α-methyl group, such as obtusifoliol and lanosterol. The enzyme catalyses two successive hydroxylations of the 14α-methyl group, followed by elimination as formate, leaving a 14(15) double bond. Group: Enzymes. Synonyms: obtusufoliol 14-demethylase; lanosterol 14-demethylase; lanosterol 14α-demethylase; sterol 14-demethylase. Enzyme Commission Number: EC 1.14.13.70. CAS No. 60063-87-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0877; sterol 14α-demethylase; EC 1.14.13.70; 60063-87-8; obtusufoliol 14-demethylase; lanosterol 14-demethylase; lanosterol 14α-demethylase; sterol 14-demethylase. Cat No: EXWM-0877. | |
| Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester | Posaconazole Diastereoisomer Related Compound 8 is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. Uses: Posaconazole intermediate. antifungal agent. Synonyms: Posaconazole Impurity 29; (5R-cis)-Toluene-4-sulfonic Acid 5-(2,4-Difluorophenyl)-5-[1,2,4]triazol-1-ylmethyltetrahydrofuran-3-ylmethyl Ester; p-Toluenesulfonic Acid (3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl Ester; 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol; Posaconazole Impurity. Grade: >95%. CAS No. 149809-43-8. Molecular formula: C21H21F2N3O4S. Mole weight: 449.47. | |
| Triadimefon | Triadimefon is a triazole fungicide used to control powdery mildew, rusts, and other fungal pests on grains, fruit and vegetable crops, turf, shrubs, and trees. Triadimefon inhibits lanosterol 14α-demethylase, interfering with oxidative demethylation reactions in the ergosterol biosynthesis pathway of fungi, and also blocks gibberellin biosynthesis. Uses: Scientific research. Group: Signaling pathways. CAS No. 43121-43-3. Pack Sizes: 10 mM * 1 mL; 250 mg. Product ID: HY-123037. | |
| Voriconazole | Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: UK-109496. CAS No. 137234-62-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-76200. | |
| Voriconazole-d3 | Voriconazole-d 3 is the deuterium labeled Voriconazole. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: UK-109496-d3. CAS No. 1217661-14-7. Pack Sizes: 500 μg; 1 mg. Product ID: HY-76200S. | |
Our database is helping our users find suppliers everyday.
