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Methylates the C-terminal leucine of phosphatase 2A. A key regulator of protein phosphatase 2A. The methyl ester is hydrolysed by EC 3.1.1.89 (protein phosphatase methylesterase-1). Occurs mainly in the cytoplasm, Golgi region and late endosomes. Group: Enzymes. Synonyms: leucine carboxy methyltransferase-1; LCMT1. Enzyme Commission Number: EC 2.1.1.233. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1836; [phosphatase 2A protein]-leucine-carboxy methyltransferase; EC 2.1.1.233; leucine carboxy methyltransferase-1; LCMT1. Cat No: EXWM-1836.
[18F]Fluciclovine
[18F]Fluciclovine is a 18F-labeled analog of the amino acid L-leucine. It is used as a diagnostic agent for PET imaging to detect prostate cancer relapse. Uses: Detection of prostate cancer relapse. Synonyms: Fluciclovine F-18; Fluciclovine (18F); (1R,3R)-1-Amino-3(18f)fluorocyclobutane-1-carboxylic acid. CAS No. 222727-39-1. Molecular formula: C5H8[18F]NO2. Mole weight: 132.12.
A product from thermal and hydrolytic degradation. Group: Biochemicals. Alternative Names: [2R-[1(S*),2R*,3S*]]-N-Formyl-L-Leucine 1-[3-Carboxy-2-hydroxynonyl]dodecyl Ester; Orlistat Impurity. Grades: Highly Purified. CAS No. 130793-28-1. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
(2S,3S,5S)-5-[(N-Formyl-L-leucyl)oxy]-2-hexyl-3-hydroxyhexadecanoic Acid-d3 (Mixture of Diastereomers)
A labeled metabolite of Orlistat. Group: Biochemicals. Alternative Names: N-Formyl-L-leucine(1S)-1-[(2S,3S)-3-carboxy-2-hydroxynonyl]dodecyl Ester-d3; 5-(Formamido-4-methylpentanoyloxy)-2-hexyl-3-hydroxyhexadecanoic Acid-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
3-Hydroxyisovalerylcarnitine
3-Hydroxyisovalerylcarnitine is a carnitine derivative. 3-Hydroxyisovaleryl carnitine in plasma may serve as a novel biomarker of biotin deficiency in humans, with its concentration increasing with biotin deficiency. Biotin deficiency reduces the activity of biotin-dependent 3-methylcrotonyl-CoA carboxylase, hinders the conversion of 3-methylcrotonyl-CoA into 3-methylglutaconyl-CoA, and impairs the leucine catabolism pathway; resulting in plasma 3-Hydroxyisovalerylcarnitine concentrations rise [1]. Uses: Scientific research. Group: Natural products. CAS No. 99159-87-2. Pack Sizes: 1 mg. Product ID: HY-N11200.
Acetolactate Synthase (Crude Enzyme)
The Acetolactate Synthase (ALS) enzyme (also known as acetohydroxy acid synthase, or AHAS) is a protein found in plants and micro-organisms. ALS catalyzes the first step in the synthesis of the branched-chain amino acids (valine, leucine, and isoleucine). It is a human protein of yet unknown function, sharing some sequence similarity with bacterial ALS, and is encoded by the ILVBL gene. This product with the indicated enzyme activity was briefly purified from engineered E. coli. Applications: Agriculture; biotechnology; drug development; synthesis; molecular biology. Group: Enzymes. Synonyms: α-acetohydroxy acid synthetase; α-acetohydroxyacid synthase; α-acetolactate synthase; α-acetolactate synthetase; acetohydroxy acid synthetase; acetohydroxyacid synthase; acetolactate pyruvate-lyase (carboxylating); acetolactic synthetase. Enzyme Commission Number: EC 2.2.1.6. CAS No. 9027-45-6. Activity: Undetermined. Appearance: Clear to translucent yellow solution. Storage: at -20 °C or lower, for at least 1 month. Source: E. coli. α-acetohydroxy acid synthetase; α-acetohydroxyacid synthase; α-acetolactate synthase; α-acetolactate synthetase; acetohydroxy acid synthetase; acetohydroxyacid synthase; acetolactate pyruvate-lyase (carboxylating); acetolactic synthetase. Pack: 100ml. Cat No: NATE-1810.
Adamantanine
Adamantanine (2-Aminoadamantane-2-carboxylic acid) inhibits the transport of methionine ( K i is 0.76 mM) and leucine into Ehrlich ascites carcinoma cells. Adamantanine inhibits proliferation of P388 lymphocytic leukemia cells with an IC 50 of >1 mM. Adamantanine inhibits the leucine aminopeptidase with an I/S 0.5 of 10.5 [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-Aminoadamantane-2-carboxylic acid. CAS No. 42381-05-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121123.
α-?Fructoselysine Dihydrochloride
α-Fructoselysine Dihydrochloride is used in preventing the breakdown and glycation of collagen. Analogue of Fructose-leucine, An amadori compound having the potential to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis. Synonyms: (S)-1-[(5-Amino-1-carboxypentyl)amino]-1-deoxy-D-fructose Dihydrochloride; Fructoselysine Dihydrochloride; Fructosyllysine Dihydrochloride; Nα-(1-Deoxy-D-fructos-1-yl)-L-lysine Dihydrochloride. Grades: 95%. CAS No. 96192-34-6. Molecular formula: C12H24N2O7 2HCl. Mole weight: 308.33.
Angiotensin I (1-9)
Angiotensin I (1-9) is a 9-amino acid peptide formed when Angiotensin converting enzyme 2 (ACE2) hydrolyzes the carboxy-terminal leucine of Angiotensin I. It is an anti-cardiac hypertrophy drug with the functions of human metabolite, rat metabolite, antihypertensive agent and cardiac protective agent. Synonyms: H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-OH; L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidine; L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro-L-Phe-L-His. Grades: ≥95% by HPLC. CAS No. 34273-12-6. Molecular formula: C56H78N16O13. Mole weight: 1183.32.
Boc-leu-oh·h2o. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Einecs 236-073-2;Leucine, N-carboxy-, N-tert-butyl ester, L- (8ci);Nsc 108690;tert-Butoxycarbonyl-L-leucine. Product Category: Heterocyclic Organic Compound. CAS No. 53296-34-7. Molecular formula: C11H21NO4.H2O. Mole weight: 249.305. Purity: 0.96. IUPACName: (2S)-4-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid. Canonical SMILES: C1C2C=CC1C3C2C4C3C5CC4C=C5. Product ID: ACM53296347. Alfa Chemistry ISO 9001:2015 Certified.
DL-Alanine
Alanine (abbreviated as Ala or A; encoded by the codons GCU, GCC, GCA, and GCG) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated -NH3+ form under biological conditions), an α-carboxylic acid group (which is in the deprotonated -COO- form under biological conditions), and a side chain methyl group, classifying it as a nonpolar (at physiological pH), aliphatic amino acid. It is non-essential in humans, meaning the body can synthesize it.The L-isomer (left-handed) of alanine is one of the 20 amino acids encoded by the human genetic code. L-Alanine is second only to leucine in rate of occurrence, accounting for 7.8% of the primary structure in a sample of 1,150 proteins. The right-handed form, D-Alanine occurs in bacterial cell walls and in some peptide antibiotics. Synonyms: DL-Ala-OH; (R,S)-2-Aminopropionic acid. Grades: 98.5-101.0% (Assay by titration). CAS No. 302-72-7. Molecular formula: C3H7NO2. Mole weight: 89.09.
D-Trp-Leuprolide
D-Trp-Leuprolide is an impurity of Leuprolide, which is a synthetic nonapeptide analog of gonadotropin-releasing hormone used as an antineoplastic agent, a gonadotropin-releasing hormone agonist, and an anti-estrogen. Synonyms: 5-Oxo-L-prolyl-L-histidyl-D-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide; Pyr-His-D-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt; (S)-N-ethyl-1-(((S)-5-oxopyrrolidine-2-carbonyl)-L-histidyl-D-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl)pyrrolidine-2-carboxamide; L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-D-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-; 1-9-Luteinizing hormone-releasing factor (swine), 3-D-tryptophan-6-D-leucine-9-(N-ethyl-L-prolinamide)-; Leuprorelin EP Impurity E. Grades: ≥95%. CAS No. 1926163-23-6. Molecular formula: C59H84N16O12. Mole weight: 1209.42.
Fructose L-Arginine Adduct
α-Fructose L-Arginine is an analogue of Fructose-leucine, an amadori compound having the potential properties to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis. Synonyms: (S)1-[[4-[(Aminoiminomethyl)amino]-1-carboxybutyl]amino]-1-deoxy-D-fructose; D-1-[(1-Carboxy-4-guanidinobutyl)amino]-1-deoxy-fructose. CAS No. 25020-14-8. Molecular formula: C12H24N4O7. Mole weight: 336.34.
Fructose-leucine (mixture of diastereomers)
An Amadori compound having the potential to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis. Synonyms: N-(1-Deoxy-D-fructos-1-yl)-L-leucine; (S)-1-[(1-Carboxy-3-methylbutyl)amino]-1-deoxy-D-fructose; D-1-[(L-1-Carboxy-3-methylbutyl)amino]-1-deoxy-fructose; 1-Deoxy-1-L-leucino-D-fructose; Fructoseleucine. Grades: 98%. CAS No. 34393-18-5. Molecular formula: C12H23NO7. Mole weight: 293.31.
Fructose-leucine(mixture of diastereomers)
Fructose-leucine(mixture of diastereomers). Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-(1-Deoxy-D-fructos-1-yl)-L-leucine; (S)-1-[(1-Carboxy-3-methylbutyl)amino]-1-deoxy-D-fructose; D-1-[(L-1-Carboxy-3-methylbutyl)amino]-1-deoxy-fructose; 1-Deoxy-1-L-leucino-D-fructose; Fructoseleucine. Product Category: Heterocyclic Organic Compound. Appearance: Off-White to Pale Yellow Solid. CAS No. 34393-18-5. Molecular formula: C12H23NO7. Mole weight: 293.31. Purity: 0.96. IUPACName: (2R)-4-methyl-2-[[(3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylamino]pentanoic acid. Canonical SMILES: CC(C)CC(C(=O)O)NCC1(C(C(C(CO1)O)O)O)O. Product ID: ACM34393185. Alfa Chemistry ISO 9001:2015 Certified.
Glyoxylic Acid Hydrate-13C2
Glyoxylic Acid Hydrate-13C2 is the labelled hydrated analog of Glyoxylic Acid (G754995) which is used as a reagent in the synthesis of N-{[6-chloro-4- (2, 6-dimethoxyphenyl) quinazolin-2-yl]carbonyl}-L-leucine, a novel nonpeptide chemotype selective for neurotensin receptor 2. Also used as a reagent in the synthesis of elemonic acid derivatives as Pin1 inhibitors. Glyoxylic Acid-13C2 was used in the synthesis of carbon labelled 6-N-carboxymethyllysine (CML) which is the most used marker for advanced glycation endproducts in food analysis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: 3C2H4O4, Molecular Weight: 94.04. US Biological Life Sciences.
Isovaleryl-L-carnitine is a naturally occurring acylcarnitine metabolized from leucine via a deficiency of the mitochondrial enzyme isovaleryl-CoA dehydrogenase, which results in an accumulation of derivatives of isovaleryl-CoA. Synonyms: L-Isovalerylcarnitine; [(2R)-3-carboxy-2-(3-methylbutanoyloxy)propyl]-trimethylazanium chloride. Grades: ≥95%. CAS No. 139144-12-0. Molecular formula: C12H24NO4·Cl. Mole weight: 281.78.
L-377202
L-377202 is a prodrug in which a peptide is covalently conjugated with the anthracycline antineoplastic antibiotic doxorubicin. This complex is hydrolyzed by the enzyme prostate-specific antigen (PSA), resulting in the formation of doxorubicin and leucine-doxorubicin. Selective targeting of these drugs to prostate tumor cells occurs because the hydrolyzing PSA enzyme is localized to the prostate gland. Doxorubicin and leucine-doxorubicin intercalate into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. These agents also produce toxic free-radical intermediates and interact with cell membrane lipids causing lipid peroxidation. Synonyms: L 377202; L377202; L-377,202; L 377,202; L377,202; (8S,10S)-10-[[3-[[1-(4-Carboxybutyryl)-t4Hyp-Ala-Ser-[(S)-2-cyclohexyl-Gly-]Gln-Ser-Leu-]amino]-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl]oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione. CAS No. 207395-85-5. Molecular formula: C65H89N9O25. Mole weight: 1396.46.
Leucinostatin H
It is produced by the strain of Paecilomyces marquandii. It's a peptide antibiotic. It has anti-gram-positive bacterial and fungal effects. Synonyms: Paecilotoxin H; N-(1-(aminooxy)-26-(1-hydroxy-2-methylpropyl)-17,20-diisobutyl-4,11,11,14,14,23,23,31-octamethyl-6,10,13,16,19,22,25,28-octaoxo-5,9,12,15,18,21,24,27-octaazadotriacontan-29-yl)-4-methyl-1-((R,E)-4-methylhex-2-enoyl)pyrrolidine-2-carboxamide; Leucinostatin A, 2-L-leucine, N9-oxide. CAS No. 109539-58-4. Molecular formula: C57H103N11O12. Mole weight: 1134.49.
Leu-D-Leu
Leu-D-Leu is a specific substrate for D-peptidase S, an intracellular carboxypeptidase-like enzyme that preferentially hydrolyzes dipeptides containing hydrophobic D-amino acids. Synonyms: l-Leucyl-d-leucine; D-Leucine, L-leucyl-; N-L-Leucyl-D-leucine; (R)-2-((S)-2-amino-4-methylpentanamido)-4-methylpentanoic acid. CAS No. 17665-02-0. Molecular formula: C12H24N2O3. Mole weight: 244.33.
Leuprolide Acetate EP Impurity E
Leuprolide Acetate EP Impurity E. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Leuprolide Acetate EP Impurity E, 1-9-Luteinizing hormone-releasing factor (swine), 3-D-tryptophan-6-D-leucine-9-(N-ethyl-L-prolinamide)-,L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-D-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-. CAS No. 1926163-23-6. IUPAC Name: (2S)-N-[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-carbamimidamido-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide. Molecular Formula: C59H84N16O12. Mole Weight: 1209.40. Catalog: APS1926163236. SMILES: CCNC (=O)[C@@H]1CCCN1C (=O)[C@H] (CCCNC (=N)N)NC (=O)[C@H] (CC (C)C)NC (=O)[C@@H] (CC (C)C)NC (=O)[C@H] (Cc2ccc (O)cc2)NC (=O)[C@H] (CO)NC (=O)[C@@H] (Cc3c[nH]c4ccccc34)NC (=O)[C@H] (Cc5c[nH]cn5)NC (=O)[C@@H]6CCC (=O)N6. Format: Neat.
Leuprolide Acetate EP Impurity H
Leuprolide Acetate EP Impurity H. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Leuprolide Acetate EP Impurity H,Luteinizing hormone-releasing factor (swine), 6-D-leucine-7-D-leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide- (9CI), Luteinizing hormone-releasing factor (pig), 6-D-leucine-7-D-leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide-. CAS No. 112710-58-4. IUPAC Name: (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2R)-1-[[(2S)-5-carbamimidamido-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide. Molecular Formula: C59H84N16O12. Mole Weight: 1209.40. Catalog: APS112710584. SMILES: CCNC (=O)[C@@H]1CCCN1C (=O)[C@H] (CCCNC (=N)N)NC (=O)[C@@H] (CC (C)C)NC (=O)[C@@H] (CC (C)C)NC (=O)[C@H] (Cc2ccc (O)cc2)NC (=O)[C@H] (CO)NC (=O)[C@H] (Cc3c[nH]c4ccccc34)NC (=O)[C@H] (Cc5c[nH]cn5)NC (=O)[C@@H]6CCC (=O)N6. Format: Neat.
Native Bovine α-Chymotrypsin
Chymotrypsin is a digestive enzyme component of pancreatic juice acting in the duodenum where it performs proteolysis, the breakdown of proteins and polypeptides. Chymotrypsin preferentially cleaves peptide amide bonds where the carboxyl side of the amide bond (the P1 position) is a large hydrophobic amino acid (tyrosine, tryptophan, and phenylalanine). These amino acids contain an aromatic ring in their sidechain that fits into a 'hydrophobic pocket' (the S1 position) of the enzyme. It is activated in the presence of trypsin. Applications: Chymotrypsin (ec 3.4.21.1, chymotrypsins a and b, alpha-chymar ophth, avazyme, chymar, chymotest, enzeon, quimar, quimotrase, alpha-chym...ate p1 sidechain and the enzyme s1 binding cavity accounts for the substrate specificity of this enzyme. chymotrypsin also hydrolyzes other amide bonds in peptides at slower rates, particularly those containing leucine and methionine at the p1 position. structurally, it is the archetypal structure for its superfamily, the pa clan of proteases. Group: Enzymes. Synonyms: EC 3.4.21.1; α-Chymotrypsin; chymotrypsins A and B; alpha-chymar ophth; avazyme; chymar; chymotest; enzeon; quimar; quimotrase; alpha-chymar; alpha-chymotrypsin A; alpha-chymotrypsin; Chymotrypsin. Enzyme Commission Number: EC 3.4.21.1. CAS No. 9004-7-3. Chymotrypsin. Activity: > 40 units/mg protein. Sto
Native Bovine Carboxypeptidase A
Carboxypeptidase as isolated from Bovine pancreas glands is a metalloenzyme that contains 1 g atom of zinc per mole of protein. It catalyzes the hydrolysis of the carboxyl-terminal peptide bond in peptides and proteins. It is primarily specific to aromatic and hydrophobic side chains such as phenylalanine, tryptophan or leucine. The enzyme also exhibits esterase activity. It is inhibited by beta-phenylpropionate and indole acetate. Protein determined by e1%/278. Applications: Carboxypeptidase a from bovine pancreas has been used in a study to investigate the expression of a soluble and activatable form of bovine procarboxypeptidase a in escherichia coli. carboxypeptidase a fr...dase A1; pancreatic procarboxypeptidase A; 11075-17-5; Carboxypolypeptidase; Peptidyl-L-amino-acid hydrolase; carboxypeptidase A; carboxypolypeptidase; pancreatic carboxypeptidase A; tissue carboxypeptidase A. Enzyme Commission Number: EC 3.4.17.1. CAS No. 11075-17-5. CPA1. Mole weight: mol wt ~35 kDa. Activity: > 50 units/mg protein. Storage: 2-8°C. Form: aqueous suspension. Source: Bovine pancreas. Species: Bovine. EC 3.4.17.1; CPA1; CPA; carboxypeptidase A1; pancreatic procarboxypeptidase A; 11075-17-5; Carboxypolypeptidase; Peptidyl-L-amino-acid hydrolase; carboxypeptidase A; carboxypolypeptidase; pancreatic carboxypeptidase A; tissue carboxypeptidase A. Cat No: NATE-0150
N-D-Gluconoyl-L-leucine
N-D-Gluconoyl-L-leucine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-D-gluconoyl-L-leucine;N-[(S)-1-Carboxy-3-methylbutyl]-D-gluconamide;Einecs 240-030-3. Product Category: Heterocyclic Organic Compound. CAS No. 15893-50-2. Molecular formula: C12H23NO8. Mole weight: 309.31292. Product ID: ACM15893502. Alfa Chemistry ISO 9001:2015 Certified.
Neuromedin N
Neuromedin N is an intricate peptide extensively investigated within the biomedical arena, offering profound insights into its multifaceted involvement in studying diverse neurological disorders. Acting upon distinct receptors both in the central nervous system and peripheral tissues, this product exhibits the potential to exert considerable impact on the modulation of neuronal activity. Synonyms: Neuromedin N; Lys-ile-pro-tyr-ile-leu; 102577-25-3; 92169-45-4; Lysyl-isoleucyl-prolyl-tyrosyl-isoleucyl-leucine; Neuromedin N (rat, mouse, porcine, canine); H-Lys-Ile-Pro-Tyr-Ile-Leu-OH; NmN-125; CHEMBL1558364; DTXSID20145280; HY-P0079; AKOS024456846; CS-5506; NCGC00167134-01; MS-31303; Q7002397; (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid; (S)-2-((2S,3S)-2-((S)-2-((S)-1-((2S,3S)-2-((S)-2,6-diaminohexanamido)-3-methylpentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid. Grades: 95%. CAS No. 102577-25-3. Molecular formula: C38H63N7O8. Mole weight: 745.9.
opine dehydrogenase
In the forward direction, the enzyme from Arthrobacter sp. acts also on secondary amine dicarboxylates such as N-(1-carboxyethyl)methionine and N-(1-carboxyethyl)phenylalanine. Dehydrogenation forms an imine, which dissociates to the amino acid and pyruvate. In the reverse direction, the enzyme acts also on neutral amino acids as an amino donor. They include L-amino acids such as 2-aminopentanoic acid, 2-aminobutyric acid, 2-aminohexanoic acid, 3-chloroalanine, O-acetylserine, methionine, isoleucine, valine, phenylalanine, leucine and alanine. The amino acceptors include 2-oxoacids such as pyruvate, oxaloacetate, glyoxylate and 2-oxobutyrate. Group: Enzymes. Synonyms: (2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate dehydrogenase (NAD+, L-aminopentanoate-forming). Enzyme Commission Number: EC 1.5.1.28. CAS No. 108281-02-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1510; opine dehydrogenase; EC 1.5.1.28; 108281-02-3; (2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate dehydrogenase (NAD+, L-aminopentanoate-forming). Cat No: EXWM-1510.
Orlistat Impurity M1
An impurity of Orlistat, which a pancreatic lipase inhibitor acting locally in the gastrointestinal tract to inhibit lipase. Synonyms: (2S,3S,5S)-5-[(N-Formyl-L-leucyl)oxy]-2-hexyl-3-hydroxyhexadecanoic Acid; N-Formyl-L-leucine(1S)-1-[(2S,3S)-3-carboxy-2-hydroxynonyl]dodecyl Ester; 5-(Formamido-4-methylpentanoyloxy)-2-hexyl-3-hydroxyhexadecanoic Acid; Orlistat Impurity M1. Grades: > 95%. CAS No. 130676-66-3. Molecular formula: C29H55NO6. Mole weight: 513.76.
p53 17-26
P53 (17-26) is the 17-26 amino acid fragment of P53. P53 (17-26) is the mdm-2-binding domain. Synonyms: H-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-OH; L-alpha-glutamyl-L-threonyl-L-phenylalanyl-L-seryl-L-alpha-aspartyl-L-leucyl-L-tryptophyl-L-lysyl-L-leucyl-L-leucine; (2S, 5S, 8S, 11S, 14S, 17S, 20S, 23S, 26S, 29S)-11-((1H-indol-3-yl)methyl)-29-amino-8-(4-aminobutyl)-23-benzyl-17-(carboxymethyl)-26-((R)-1-hydroxyethyl)-20-(hydroxymethyl)-2, 5, 14-triisobutyl-4, 7, 10, 13, 16, 19, 22, 25, 28-nonaoxo-3, 6, 9, 12, 15, 18, 21, 24, 27-nonaazadotriacontane-1, 32-dioic acid. Grades: ≥95%. CAS No. 488118-64-5. Molecular formula: C60H90N12O17. Mole weight: 1251.43.
pp60 c-src (521-533) (phosphorylated)
pp60 c-src (521-533) (phosphorylated), the pp60 c-src carboxy-terminal phosphoregulatory peptide phosphorylated at Tyr527, participates in the regulation of kinase activity through binding intramolecularly or intermolecularly to the SH2 domain of the pp60 c-src protein. Synonyms: H-Thr-Ser-Thr-Glu-Pro-Gln-Tyr(PO3H2)-Gln-Pro-Gly-Glu-Asn-Leu-OH; L-threonyl-L-seryl-L-threonyl-L-alpha-glutamyl-L-prolyl-L-glutaminyl-O4-phosphono-L-tyrosyl-L-glutaminyl-L-prolyl-glycyl-L-alpha-glutamyl-L-asparagyl-L-leucine; L-Leucine, L-threonyl-L-seryl-L-threonyl-L-a-glutamyl-L-prolyl-L-glutaminyl-O-phosphono-L-tyrosyl-L-glutaminyl-L-prolylglycyl-L-a-glutamyl-L-asparaginyl-; Thr-Ser-Thr-Glu-Pro-Gln-O-Phosphono-Tyr-Gln-Pro-Gly-Glu-Asn-Leu-OH. Grades: >99%. CAS No. 149299-77-4. Molecular formula: C62H95N16O28P. Mole weight: 1543.48.
Prolylleucine
Prolylleucine is a dipeptide containing branched-chain amino acids that affects circadian rhythms and behavior in animals. Synonyms: ((Benzyloxy)carbonyl)-L-prolyl-D-leucine; Cbz-Pro-D-Leu-OH; N-benzyloxycarbonyl-L-prolyl-D-leucine; D-Leucine, N-(1-((phenylmethoxy)carbonyl)-L-prolyl)-; (R)-2-((S)-1-(benzyloxycarbonyl)pyrrolidine-2-carboxamido)-4-methylpentanoic acid. Grades: ≥95%. CAS No. 61596-47-2. Molecular formula: C19H26N2O5. Mole weight: 362.42.
protein phosphatase methylesterase-1
A key regulator of protein phosphatase 2A. The methyl ester is formed by EC 2.1.1.233 (leucine carboxy methyltransferase-1). Occurs mainly in the nucleus. Group: Enzymes. Synonyms: PME-1; PPME1. Enzyme Commission Number: EC 3.1.1.89. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3518; protein phosphatase methylesterase-1; EC 3.1.1.89; PME-1; PPME1. Cat No: EXWM-3518.
(S)-(-)-4-Isobutyloxazolidine-2,5-Dione. Group: Biochemicals. Alternative Names: (4R)-4-Isobutyloxazolidine-2,5-Dione; (4R)-4-Isobutyloxazolidine-2,5-Quinone; L-Leucine N-carboxy anhydride. Grades: Highly Purified. CAS No. 3190-70-3. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C7H11NO3. US Biological Life Sciences.
Worldwide
(S)-4-tert-Butyloxazolidine-2,5-dione
(S)-4-tert-Butyloxazolidine-2,5-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: L-TERT-LEUCINE NCA;(S)-4-TERT-BUTYLOXAZOLIDINE-2,5-DIONE;L-tert-Leucine N-carboxyanhydride. Product Category: Heterocyclic Organic Compound. CAS No. 62965-56-4. Molecular formula: C7H11NO3. Mole weight: 157.17. Purity: 0.96. IUPACName: (4S)-4-tert-butyl-1,3-oxazolidine-2,5-dione. Canonical SMILES: CC(C)(C)C1C(=O)OC(=O)N1. Density: 1.164g/cm³. ECNumber: 613-120-9. Product ID: ACM62965564. Alfa Chemistry ISO 9001:2015 Certified.
tert-Butoxycarbonyl-L-leucine
Protected amino acid with antimicrobial activity. Group: Biochemicals. Alternative Names: N-[ (1, 1-Dimethylethoxy) carbonyl]-L-leucine; N-(tert-Butoxycarbonyl)-L-leucine; N- (α -tert-Butoxycarbonyl) leucine; N-Boc-L-Leucine; N-Carboxy-L-leucine N-tert-Butyl Ester; N-[ (1, 1-Dimethylethoxy) carbonyl]leucine; N-tert-Butoxycarbonylleucine; NSC 108690; N-Boc-L-leucine. Grades: Highly Purified. CAS No. 13139-15-6. Pack Sizes: 5g. US Biological Life Sciences.
Worldwide
Uroguanylin
Uroguanylin belongs to the guanylin family of cyclic guanosine monophosphate (cGMP) regulatory peptides. Uroguanylin activates the guanylate cyclase-C/cyclic guanosine monophosphate pathway to induce analgesic effects in colonic hypersensitive animal models, revealing a new approach for the treatment of abdominal pain. Synonyms: Uroguanylin Topoisomer A (human); UGN Topoisomer A (human); H-Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH (Disulfide bridge: Cys4-Cys12, Cys7-Cys15); UGN (human); L-asparagyl-L-alpha-aspartyl-L-alpha-aspartyl-L-cysteinyl-L-alpha-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparagyl-L-valyl-L-alanyl-L-cysteinyl-L-threonyl-glycyl-L-cysteinyl-L-leucine (4->12),(7->15)-bis(disulfide); L-Asparaginyl-L-α -aspartyl-N-{(1R, 4S, 7S, 10S, 13S, 16R, 19S, 22S, 25R, 32S, 38R)-10-(2-amino-2-oxoethyl)-22-(2-carboxyethyl)-38-{[(1S)-1-carboxy-3-methylbutyl]carbamoyl}-32-[(1R)-1-hydroxyethyl]-19-isobutyl-7, 13-diisopropyl-4-methyl-3, 6, 9, 12, 15, 18, 21, 24, 30, 33, 36-undecaoxo-27, 28, 40, 41-tetrathia-2, 5, 8, 11, 14, 17, 20, 23, 31, 34, 37-undecaazabicyclo[14. 13. 13]dotetracont-25-yl}-L-α -asparagine. Grades: ≥90% by HPLC. CAS No. 154525-25-4. Molecular formula: C64H102N18O26S4. Mole weight: 1667.86.
valine decarboxylase
A pyridoxal-phosphate protein. Also acts on L-leucine. Group: Enzymes. Synonyms: leucine decarboxylase; L-valine carboxy-lyase. Enzyme Commission Number: EC 4.1.1.14. CAS No. 9031-16-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4758; valine decarboxylase; EC 4.1.1.14; 9031-16-7; leucine decarboxylase; L-valine carboxy-lyase. Cat No: EXWM-4758.
Xenopsin
Xenopsin, the neurotensin-like octapeptide from Xenopusskin at the carboxyl terminus of its precursor, shows sequence homology to mammalian neurotensin and shares a number of its biological properties. Synonyms: H-Pyr-Gly-Lys-Arg-Pro-Trp-Ile-Leu-OH; 5-oxo-L-prolylglycyl-L-lysyl-L-arginyl-L-prolyl-L-tryptophyl-L-isoleucyl-L-leucine. Grades: >98%. CAS No. 51827-01-1. Molecular formula: C47H73N13O10. Mole weight: 980.16.
Z-Leu-Arg-AMC
Z-Leu-Arg-AMC is a 4-methylcoumarinyl-7-amide (Amc) leucine derivative with carboxybenzoyl (Z). Z-Leu-Arg-AMC is the active site of cysteine proteinase trypanopain-Tb from Trypanosoma brucei brucei [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 156192-32-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-142021.
Z-Phe-Leu-OH
Substrate for carboxypeptidase Y. Synonyms: Z-L-phenylalanyl-L-leucine; (S)-2-((S)-2-(benzyloxycarbonylamino)-3-phenylpropanamido)-4-methylpentanoic acid; Z Phe Leu OH. Grades: ≥ 98% (HPLC). CAS No. 4313-73-9. Molecular formula: C23H28N2O5. Mole weight: 412.49.
1,3-Bis-(Z-Leu-Leu)-diaminoacetone
1,3-Bis-(Z-Leu-Leu)-diaminoacetone, a cysteine protease inhibitor, can specifically and efficiently inhibit the processing of p-Prl signal peptide (IC50 ca. 50 nM) without affecting the activity of signal peptidase and lysosomal cathepsin, proteasome, and other proteases. Synonyms: (Z-LL)2 Ketone; Z-Leu-Leu-NH-CH2-CO-CH2-NH-Leu-Leu-Z; 2,2'-(2-Oxo-1,3-propanediyl)bis[N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucinamide; 1,3-di-(N-carboxybenzoyl-leucyl-leucyl)aminoacetone; Dibenzyl [(4S,7S,15S,18S)-7,15-diisobutyl-2,20-dimethyl-5,8,11,14,17-pentaoxo-6,9,13,16-tetraazahenicosane-4,18-diyl]biscarbamate. Grades: ≥95%. CAS No. 313664-40-3. Molecular formula: C43H64N6O9. Mole weight: 809.00.
It is produced by the strain of Paecilomyces marquandii. It's a peptide antibiotic. It has anti-gram-positive bacterial and fungal effects. It has in vitro cytotoxic activity against HeLa 850, KB cells and sensitive leukemia cells P388 with ID50 of 1.00 ng/mL. Synonyms: Paecilotoxin D; (4R) -N- [1- [ [2-hydroxy-3-methyl-1- [2- [ [3-methyl-1- [ [3-methyl-1- [2- [2- [2- (1-methylaminopropan-2-ylcarbamoyl) ethylcarbamoyl] propan-2-ylcarbamoyl] propan-2-ylcarbamoyl] butyl] carbamoyl] butyl] carbamoyl] propan-2-ylcarbamoyl] butyl] carbamoyl] -3-methyl-butyl] -4-methyl-1- [ (E, 4S) -4-methylhex-2-enoyl] pyrrolidine-2-carboxamide. CAS No. 100334-47-2. Molecular formula: C56H101N11O11. Mole weight: 1104.47.
Leucinostatin K
It is produced by the strain of Paecilomyces marquandii. It's a peptide antibiotic. It has anti-gram-positive bacterial and fungal effects. Synonyms: Leucinostatin A, N9-oxide; b-Alaninamide, cis-4-methyl-1-(4-methyl-1-oxo-2-hexenyl)-L-prolyl-(4S,6S)-6-hydroxy-4-methyl-8-oxo-L-2-aminodecanoyl-threo-3-hydroxy-L-leucyl-2-methylalanyl-L-leucyl-L-leucyl-2-methylalanyl-2-methylalanyl-N-[2-(dimethylamino)-1-methylethyl]-, N9-oxide, [1[S-(E)],9(S)]-; N-(1-(aminooxy)-33-hydroxy-26-(1-hydroxy-2-methylpropyl)-17,20-diisobutyl-4,11,11,14,14,23,23,31-octamethyl-6,10,13,16,19,22,25,28,35-nonaoxo-5,9,12,15,18,21,24,27-octaazaheptatriacontan-29-yl)-4-methyl-1-((R,E)-4-methylhex-2-enoyl)pyrrolidine-2-carboxamide. CAS No. 109539-57-3. Molecular formula: C62H111N11O14. Mole weight: 1234.61.
Ro 09-1679
Ro 09-1679 is a thrombin inhibitor produced by Mortierella alpina NR6773. It inhibits thrombin, Factor Xa, trypsin and papain with IC50 values of 33.6, 3.3, 0.04 and 0.0346 μmol/L. Synonyms: L-Leucinamide, N2-(3-carboxy-1-oxo-2-propenyl)-L-arginyl-N-(4-((aminoiminomethyl)amino)-1-formylbutyl)-, (S-(E))-. CAS No. 141426-89-3. Molecular formula: C22H39N9O6. Mole weight: 525.61.
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