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| Product | Description | |
|---|---|---|
| LPA1 receptor antagonist 1 | LPA1 receptor antagonist 1 is a highly selective Lysophosphatidic Acid receptor-1 (LPA1) antagonist with an IC 50 of 25 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1396006-71-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-18076. |  |
| LPA2 antagonist 1 | LPA2 antagonist 1 is a LPA2 antagonist with an IC50 of 17 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1017606-66-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18075. | |
| LPA Biotin | LPA Biotin is labelled at the sn-1 position. LPA is a small lysophospholipid involved in diverse cellular processes such as cell proliferation, chemotaxis, platelet aggregation, wound healing, angiogenesis, tumor invasion, and smooth muscle contraction. Synonyms: Lysophosphatidic Acid Biotin. Molecular formula: C31H56N4NaO10PS. Mole weight: 730.83. |  |
| 12:0 Biotinyl LPA (ammonium salt) | Biotinyl LPA (ammonium salt) 12:0, a lipid compound extensively utilized in research to elucidate the intricate mechanisms of cell signaling cascades, holds promise in drug discovery for combating disorders arising from perturbations in lipid metabolic pathways. Synonyms: 1-[12-biotinyl(aminododecanoyl)]-2-hydroxy-sn-glycero-3-phosphate (ammonium salt). Grade: >99%. CAS No. 799812-69-4. Molecular formula: C25H49N4O9PS. Mole weight: 612.72. | |
| 17:0 Cyclic LPA | 17:0 Cyclic LPA. Group: Others. Purity: >99%. Mole weight: 423.524. Stability: 1 Years. Storage: -20°C. 1-Heptadecanoyl-glycero-2,3-cyclic-phosphate (ammonium salt); 17:0 Cyclic LPA. Cat No: PHOZ-181. |  |
| 2- (2?-Di-tert-butylphosphine) biphenylpalladium (II) Acetate | 2- (2?-Di-tert-butylphosphine) biphenylpalladium (II) Acetate is a precatalyst for Buchwald-Hartwig amination reaction. It is also used to prepare anticancer LPA2 antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 577971-19-8. Pack Sizes: 100mg, 250mg. Molecular Formula: C22H29O2PPd, Molecular Weight: 462.86. US Biological Life Sciences. |  Worldwide |
| Anti-LPA1, C-Terminal antibody produced in rabbit | ~1 mg/mL, IgG fraction of antiserum, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. |  |
| Anti-LPAR2 antibody produced in rabbit | affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-LPAR1 antibody produced in mouse | clone 2E2, purified immunoglobulin, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| TC LPA5 4 | TC LPA5 4. Group: Biochemicals. Grades: Purified. CAS No. 1393814-38-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC LPA5 4 | TC LPA5 4 is a LPA 5 (GPR92) -specific non-lipid antagonist. TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelet (LPA 5 -RH7777 cell line) with an IC 50 of 800 nM. TC LPA5 4 displays selectivity for LPA 5 over 80 other screened agent targets [1]. TC LPA5 4 inhibits cell proliferation and migration of thyroid cancer cells [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1393814-38-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107615. | |
| 16:0 Lyso PA (sodium salt) | 1-Palmitoyl lysophosphatidic acid (1-Palmitoyl LPA) is a LPA analog containing palmitic acid at the sn-1 position. LPA binds to one of five different G protein-coupled receptors (GPCRs) to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. Synonyms: 1-hexadecanoyl-sn-glycero-3-phosphate (sodium salt); PA(16:0/0:0); 1-Palmitoyl lysophosphatidic acid sodium salt. Grade: ≥98%. CAS No. 17618-08-5. Molecular formula: C19H38NaO7P. Mole weight: 454.45. | |
| 1-Hexadecylglycero-3-phosphate | 1-Hexadecyl lysophosphatidic acid is an ether analog of lysophosphatidic acid (LPA) containing a hexadecyl group in the sn-1 position. LPA binds to five different G protein-coupled receptors and mediates a variety of biological responses, including cell proliferation, smooth muscle contraction, platelet aggregation, neurite contraction, and cell motility. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 1-Hex-GPA. CAS No. 52603-03-9. Pack Sizes: 1 mg. Product ID: HY-W127502. | |
| 1-Hexadecyl lysophosphatidic acid | 1-Hexadecyl lysophosphatidic acid is an ether analog of lysophosphatidic acid (LPA) containing a hexadecyl group at the sn-1 position. Synonyms: Alkyl glycero phosphate 16:0; 1-Hexadecyl-2-hydroxy-sn-glycero-3-phosphate; (3-hexadecoxy-2-hydroxypropyl) dihydrogen phosphate. Grade: ≥98%. CAS No. 52603-03-9. Molecular formula: C19H41O6P. Mole weight: 396.5. | |
| 1-Hexadecyl lysophosphatidic acid sodium salt | 1-Hexadecyl lysophosphatidic acid is an ether analog of lysophosphatidic acid (LPA) containing a hexadecyl group at the sn-1 position. Synonyms: Alkyl glycero phosphate 16:0 sodium salt; 1-Hexadecyl-2-hydroxy-sn-glycero-3-phosphate sodium salt; AGP 16:0 sodium salt. Grade: ≥98%. Molecular formula: C19H40O6P·Na. Mole weight: 418.5. | |
| 1-Octadecyl lysophosphatidic acid | 1-Octadecyl lysophosphatidic acid (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position. LPA binds to one of five different G protein linked receptors to mediate a variety of biological responses. Synonyms: 1-Octadecyl LPA; (2-hydroxy-3-octadecoxypropyl) dihydrogen phosphate. Grade: ≥95%. CAS No. 52977-29-4. Molecular formula: C21H45O6P. Mole weight: 424.6. | |
| 1-Octadecyl lysophosphatidic acid sodium salt | 1-Octadecyl lysophosphatidic acid (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position. LPA binds to one of five different G protein linked receptors to mediate a variety of biological responses. Synonyms: 1-Octadecyl LPA. Grade: ≥95%. Molecular formula: C21H44O6P·Na. Mole weight: 446.5. | |
| 1-Oleoyl lysophosphatidic acid | 1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) is an abundant lysophosphatidic acid (LPA) species with high biological activity due to its strong affinity for the LPA receptors. 1-Oleoyl lysophosphatidic acid is commonly used in most laboratories as a reagent for LPA receptor activation [1]. 1-Oleoyl lysophosphatidic acid increases SRE-driven β-galactosidase activity [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1-Oleoyl-sn-glycero-3-phosphate; 1-Oleoyl-LPA. CAS No. 65528-98-5. Pack Sizes: 5 mg (22.91 mM * 500 μL in Ethanol); 10 mg (22.91 mM * 1 mL in Ethanol); 25 mg (22.91 mM * 2.5 mL in Ethanol). Product ID: HY-137862. | |
| 1-Oleoyl lysophosphatidic acid | 1-Oleoyl lysophosphatidic acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of phospholipase D (PLD) or through a two step process involving liberation of diacylglycerol (DAG) by phospholipase C (PLC) followed by phosphorylation of DAG by diglycerol kinase. Synonyms: 1-Oleoyl-sn-glycerol 3-phosphate; Oleoyl LPA; 18:1 LPA; 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate; LysoPA(18:1). Grade: ≥95%. CAS No. 65528-98-5. Molecular formula: C21H41O7P. Mole weight: 436.50. | |
| 1-Oleoyl lysophosphatidic acid sodium | 1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) sodium, a potent bioactive phospholipid, is a LPA receptor activator. 1-Oleoyl lysophosphatidic acid sodium can promote mitosis by inducing DNA synthesis. 1-Oleoyl lysophosphatidic acid sodium is also involved in normal and pathological emotional responses, including anxiety and depression [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1-Oleoyl-sn-glycero-3-phosphate sodium; 1-Oleoyl-LPA sodium. CAS No. 325465-93-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107614. | |
| 1-Oleoyl lysophosphatidic acid sodium salt | 1-Oleoyl lysophosphatidic acid sodium salt is lysophospholipid receptor (LPA1 and LPA2) agonist. It can inhibit differentiation of neural stem cells into neurons. Synonyms: 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoricacid sodium salt; 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate (sodium salt); PA(18:1(9Z)/0:0) (sodium salt); 1-Oleoyl lysophosphatidic acid sodium salt. Grade: >99%. CAS No. 325465-93-8. Molecular formula: C21H40NaO7P. Mole weight: 458.50. | |
| 1-Oleoyl lysophosphatidic acid sodium salt | Endogenous agonist of the lysophospholipid receptors LPA1 and LPA2. Inhibits differentiation of neural stem cells (NSCs) into neurons.CAS Number:325465-93-8. Group: Biochemicals. Grades: Purified. CAS No. 325465-93-8. Pack Sizes: 1mg. Molecular Formula: C21H40NaO7P. US Biological Life Sciences. | Worldwide |
| 1-Oleoyl Lysophosphatidic Acid (Sodium Salt) | 1-Oleoyl Lysophosphatidic Acid is a lysophophatidic acid (LSA) with oleic acid in the sn-1 position that is an endogenous agonist for LPA1 and LPA2 receptors. It is reported to inhibit the differentiation of neural stem cells into neurons and is involved in multiple biological activities such as smooth muscle contraction, platelet aggregation, cell proliferation, cell migration, and calcium mobilization. 1-Oleoyl Lysophosphatidic Acid is commonly used for growth stimulation in a variety of cell lines. Group: Biochemicals. Alternative Names: 9-Octadecenoicacid (9Z)-, 2-hydroxy-3-(phosphonooxy)propyl ester, 1-Oleoyl-sn-glycerol 3-phosphate sodium salt, 1-oleoyl sodium salt, LPA sodium salt. Grades: Highly Purified. CAS No. 22556-62-3. Pack Sizes: 10mg. Molecular Formula: C21H40O7, Molecular Weight 458.5. US Biological Life Sciences. | Worldwide |
| 1-Palmitoyl lysophosphatidic acid | 1-Palmitoyl lysophosphatidic acid (1-Palmitoyl LPA) is a LPA analog containing palmitic acid at the sn-1 position. LPA binds to one of at least five different G protein-coupled receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. Synonyms: 1-Palmitoyl LPA; 1-Palmitoylglycerol 3-phosphate. Grade: ≥98%. CAS No. 22002-85-3. Molecular formula: C19H39O7P. Mole weight: 410.5. | |
| 20:4 Lyso PA (ammonium salt) | 1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. Synonyms: 1-Arachidonoyl LPA; 1-Arachidonoyl-sn-glycero-3-phosphate; 1-Eicosatetraenoyl-sn-glycero-3-PA; LPA(20:4); PA(20:4/0:0); 1-Arachidonoyl lysophosphatidic acid ammonium salt. Grade: ≥95%. CAS No. 799268-65-8. Molecular formula: C23H42NO7P. Mole weight: 475.56. | |
| 2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]butyric Acid Ethyl Ester | 2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]butyric Acid Ethyl Ester is used as a reagent to prepare N-heterocyclylcarbamates and biphenylisoxazoles as lysophosphatidic acid (LPA) receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 1282659-60-2. Pack Sizes: 250mg, 2.5g. Molecular Formula: C18H27BO4, Molecular Weight: 318.22. US Biological Life Sciences. | Worldwide |
| 2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]butyric Acid Ethyl Ester-d5 | 2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]butyric Acid Ethyl Ester-d5 is labelled 2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]butyric Acid Ethyl Ester (T302660) which is used as a reagent to prepare N-heterocyclylcarbamates and biphenylisoxazoles as lysophosphatidic acid (LPA) receptor antagonists. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 100mg. Molecular Formula: C18H22D5BO4, Molecular Weight: 323.25. US Biological Life Sciences. | Worldwide |
| 2-Fluoro-4-hydroxymethylphenol | 2-Fluoro-4-hydroxymethylphenol is used in preparation of fused imidazopyrimidinones that act as Lp-LPA2 inhibitors and also used to synthesize bicyclic inhibitors of acety-CoA carboxylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 96740-93-1. Pack Sizes: 100mg, 250mg. Molecular Formula: C7H7FO2, Molecular Weight: 142.13. US Biological Life Sciences. | Worldwide |
| (2S)-OMPT (ammonium salt) | OMPT is a selective agonist of the lysophosphatidic acid 3 (LPA3) receptor. It exhibits EC50 values of 68 nM and >6.8 μM for calcium mobilization in LPA3 and LPA2-expressing Sf9 cells, respectively. Synonyms: (2S)-2-methoxy-3-(thiophosphonooxy)propyl (9Z)-octadec-9-enoate (ammonium salt); 2(S)-OMPT (ammonium salt); 1-oleoyl-2-methyl-sn-glycero-3-phosphothionate (ammonium salt). Grade: >99%. CAS No. 645408-61-3. Molecular formula: C22H46NO6PS. Mole weight: 483.64. | |
| 2-((tert-Butyldimethylsilyloxy)methyl)furo[3,2-b]pyridine-6-carboxylic acid | 2-((tert-Butyldimethylsilyloxy)methyl)furo[3,2-b]pyridine-6-carboxylic acid. Group: Salt. Alternative Names: 2-((tert-Butyldimethylsilyloxy)methyl)-furo[3,2-b]pyridine-6-carboxylic acid, 1171920-49-2, 2-((tert-Butyldimethylsilyloxy)methyl)furo[3,2-b]pyridine-6-carboxylic acid, 2-(((tert-Butyldimethylsilyl)oxy)methyl)furo[3,2-b]pyridine-6-carboxylic acid, 2-{[(tert-butyldimethylsilyl)oxy]methyl}furo[3,2-b]pyridine-6-carboxylic acid, AC1Q1LJB, CTK7J0559, AKOS015837797, AG-A-27144, AK-55708, A-6083. CAS No. 1171920-49-2. Product ID: 2-[[tert-butyl (dimethyl)silyl]oxymethyl]furo[3, 2-b]pyridine-6-carboxylic acid. Molecular formula: 307.42. Mole weight: C15< / sub>H21< / sub>NO4< / sub>Si. LPAAHOPBWVHPDY-UHFFFAOYSA-N. 96%. |  |
| 4-Tetradecanamidobenzylphosphonic Acid | S32826 is a potent and selective inhibitor of autotaxin. Autotaxin catalyzes the transformation of lyso-phosphatidylcholine in lyso-phosphatidic acid (LPA). S32826 inhibits LPA release from adipocytes (IC50 = 90 nM) and reduces plasma autotaxin activity. Synonyms: 4-Tetradecanamidobenzylphosphonic acid. Grade: ≥98%. CAS No. 1096770-84-1. Molecular formula: C21H36NO4P. Mole weight: 397.5. | |
| AM095 | AM095, an effective LPA1 receptor antagonist, has been found to decrease dermal fibrosis caused by attenuates bleomycin. IC50: 0.98 uM and 0.73 uM for human and mouse LPA1 respectively. Synonyms: AM095 (free acid); AM-095; AM 095. Grade: 98%. CAS No. 1228690-36-5. Molecular formula: C27H24N2O5. Mole weight: 456.49. | |
| AM095 | AM095 is a selective LPA 1 receptor antagonist. The IC 50 for AM095 antagonism of LPA-induced calcium flux of human or mouse LPA 1 -transfected CHO cells is 0.025 and 0.023 μM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1345614-59-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-16039. | |
| AM095 free acid | AM095 (free acid) is a potent LPA1 receptor antagonist with IC 50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1228690-36-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-16040. | |
| AM095 sodium | AM095 is a selective LPA1 receptor antagonist. The IC50 for AM095 antagonism of LPA-induced calcium flux of human or mouse LPA1-transfected CHO cells is 0.025 and 0.023 μM, respectively. Synonyms: AM-095 sodium; AM 095 sodium. Grade: >98%. CAS No. 1345614-59-6. Molecular formula: C27H23N2NaO5. Mole weight: 478.48. | |
| AM966 | AM966 is a high affinity, selective, oral LPA1-antagonist, inhibits LPA-stimulated intracellular calcium release (IC50=17 nM). Uses: Scientific research. Group: Signaling pathways. CAS No. 1228690-19-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15277. | |
| AM 966 | AM966, a LPA1 receptor antagonist, has been found to restrain lung fibrosis in mouse model. IC50: 17 nM. Uses: Am966 is a lpa1 receptor antagonist that has been found to restrain lung fibrosis in mouse model. Synonyms: AM-966; AM 966; AM966; 2-[4-[4-[4-[[(1R)-1-(2-chlorophenyl)ethoxy]carbonylamino]-3-methyl-1,2-oxazol-5-yl]phenyl]phenyl]aceticacid; AM966; AM-966; UNII-CEO54NH393; 1228690-19-4; (R)-2-(4'-(4-(((1-(2-Chlorophenyl)ethoxy)carbonyl)amino)-3-methylisoxazol-5-yl)-[1,1'-biphenyl]-4-yl)acet. Grade: 95%. CAS No. 1228690-19-4. Molecular formula: C27H23ClN2O5. Mole weight: 490.93. | |
| (-)-AS 115 | (-)-AS 115, an isomer of AS 115, is a potent and selective inactivator of KIAA1363. KIAA1363 is an enzyme that catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network. Synonyms: (-)-AS 115; CHEMBL2069333; ()-AS 115; 2-Fluorophenyl-(2-(((1R,2S)-2-(butoxymethyl)cyclohexyl)methoxy)ethyl)carbamate; AS 115; AS115; BDBM50390508. Grade: ≥98%. CAS No. 926657-43-4. Molecular formula: C21H32FNO4. Mole weight: 381.5. | |
| AS2717638 | AS2717638 is a highly selective, brain-penetrant and orally active lysophosphatidic acid receptor 5 (LPA5) antagonist with an IC50 value of 38 nM. AS2717638 is highly selective and shows no significant antagonistic activity against other LPA receptors (LPA1, LPA2, and LPA3). AS2717638 can be used in the research of pain and neuroinflammation-related diseases[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2148339-28-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114379. | |
| AS2717638 | AS2717638 is a potent, selective, orally active and brain-penetrant lysophosphatidic acid receptor 5 (LPA5) antagonist, with an IC50 of 38 nM for hLPA5. It significantly improves allodynia induced by PGE2, PGF2α and AMPA. Synonyms: 1(2H)-Isoquinolinone, 6,7-dimethoxy-2-(5-methyl-1,2-benzisoxazol-3-yl)-4-(1-piperidinylcarbonyl)-; 6,7-Dimethoxy-2-(5-methyl-1,2-benzoxazol-3-yl)-4-(piperidin-1-ylcarbonyl)isoquinolin-1(2H)-one; 6,7-Dimethoxy-2-(5-methyl-1,2-benzoxazol-3-yl)-4-(1-piperidinylcarbonyl)-1(2H)-isoquinolinone. Grade: ≥95%. CAS No. 2148339-28-8. Molecular formula: C25H25N3O5. Mole weight: 447.48. | |
| Autotaxin Inhibitor III, PF-8380 (Atx Inhibitor III, PF-8380, 6-(3-(Piperazin-1-yl)propanoyl)-benzo[d]oxazol-2(3H)-one) | An orally bioavailable piperazinyl benzoxazolone compound that acts as a substrate competitive and tight-binding inhibitor of autotaxin activity {IC50=2.8 and 1.7nM for recombinant human enzyme-b isoform employing FS-3 and LPC (lysophosphatidyl choline) as substrates, respectively; 1.16 and 1.15nM for rat/murine enzyme-FS-3 and fetal fibroblast cell-LPC; 101nM for human whole blood}. Displays desirable pharmacokinetics properties and efficiently blocks inflammation-induced LPA (lysophosphatidic acid) production both in plasma and at the site of inflammation by 95% in rat adjuvant-induced arthritis model (30mg/kg, p.o.).CAS No:1144035-53-9. Group: Biochemicals. Grades: Highly Purified. CAS No. 1144035-53-9. Pack Sizes: 10mg. Molecular Formula: C??H??Cl?N?O?. US Biological Life Sciences. | Worldwide |
| BI-2545 | BI-2545 is a potent autotaxin (ATX) inhibitor that significantly reduces LPA, with IC 50 s of 2.2 nM and 3.4 nM for human ATX and rat ATX, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2162961-71-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124772. | |
| Bioactive Lipid Compound Library | A unique collection of 385 bioactive lipids related compounds for high throughput screening (HTS) and high content screening (HCS), including Agonists & Antagonists, Endocannabinoids, Farnesyl/geranylgeranyl derivates, HETEs deHETEs, hepoxilins, Polyunsaturated fatty acids, Leukotrienes, lipoxins, LPA & phosphatidic acids, Octadecanoids, PAFs, Prostaglandins & thromboxanes, Retinoids, vitamin D metabolites, Sphingolipids, etc. ; - Targets include GPCR, HDAC, PPAR, DNA Alkylating, EGFR, etc. ; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L7000. Categories: Bioactive Lipid Compounds Libraries. |  |
| BMP-22 | BMP-22 is an inhibitor of autotaxin with IC50 of 170 nM. It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM. BMP-22 inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC) in vitro in a concentration-dependent manner. MP-22 can decrease the number of lung metastatic foci in a B16/F10 syngeneic mouse melanoma model of lung metastasis. Synonyms: 4-pentadecylbenzylphosphonic acid; BMP22; BMP 22. Grade: ≥95%. CAS No. 1306684-90-1. Molecular formula: C22H39O3P. Mole weight: 382.52. | |
| BMS-002 | BMS-002 is a selective antogonist of lysophosphatidic acid (LPA) receptor-1 developed to treat diabetic nephropathy. In eNOS-/- db/db mouse model, BMS-002 significantly decreased the level of proteinuria. Uses: The potential treatment of diabetic nephropathy. Synonyms: BMS 002; BMS002. | |
| BMS 986020 | BMS 986020 is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist with an IC50 value less than 300 nM for human LPA1 expressing CHO cells. It inhibits bile acid and phospholipid transporters with IC50s of 4.8 μM, 6.2 μM, and 7.5 μM for BSEP, MRP4, and MDR3, respectively. BMS 986020 is used for the treatment of idiopathic pulmonary fibrosis (IPF). Synonyms: BMS-986020; BMS986020. Grade: ≥98%. CAS No. 1257213-50-5. Molecular formula: C29H26N2O5. Mole weight: 482.5. | |
| BMS-986020 | BMS-986020 (AM152) is a high-affinity and selective lysophosphatidic acid receptor 1 (LPA1) antagonist[1]. BMS-986020 inhibits bile acid and phospholipid transporters with IC50s of 4.8 ?M, 6.2 ?M, and 7.5 ?M for BSEP, MRP4, and MDR3, respectively[2]. BMS-986020 has the potential for the treatment of idiopathic pulmonary fibrosis (IPF)[3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AM152. CAS No. 1257213-50-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100619. | |
| BMS-986020 sodium | BMS-986020 (AM152) sodium is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist[1]. BMS-986020 sodium inhibits bile acid and phospholipid transporters with IC50s of 4.8 ?M, 6.2 ?M, and 7.5 ?M for BSEP, MRP4, and MDR3, respectively[2]. BMS-986020 sodium has the potential for the treatment of idiopathic pulmonary fibrosis (IPF)[3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AM152 sodium. CAS No. 1380650-53-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100619A. | |
| BMS-986020 sodium | BMS-986020 sodium is a high affinity antagonist of lysophosphatidic acid receptor 1 (LPA1) that inhibits bile acids and phospholipid transporters with IC50s of 4.8, 6.2 and 7.5 μM against BSEP, MRP4 and MDR3, respectively. It has the potential to treat idiopathic pulmonary fibrosis (IPF). Synonyms: Sodium 1-{4'-[3-methyl-4-({[(1R)-1-phenylethoxy]carbonyl}amino)-1,2-oxazol-5-yl]-4-biphenylyl}cyclopropanecarboxylate; Cyclopropanecarboxylic acid, 1-[4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl][1,1'-biphenyl]-4-yl]-, sodium salt (1:1); Sodium (R)-1-(4'-(3-methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylate. Grade: ≥95%. CAS No. 1380650-53-2. Molecular formula: C29H25N2NaO5. Mole weight: 504.51. | |
| BMS-986278 | BMS-986278 is a potent and orally active lysophosphatidic acid receptor 1 (LPA1) antagonist, with K b s of 6.9 nM and 4.0 nM for human and mouse LPA1, respectively. BMS-986278 can be used for the research of pulmonary fibrotic diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2170126-74-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139853. | |
| BMS-986278 | BMS-986278 is a potent antagonist of lysophosphatidic acid receptor 1 (LPA1), with a human LPA1 Kb of 6.9 nM. Synonyms: (1S,3S)-3-((2-Methyl-6-(1-methyl-5-(((methyl(propyl)carbamoyl)oxy)methyl)-1H-1,2,3-triazol-4-yl)pyridin-3-yl)oxy)cyclohexane-1-carboxylic acid; Cyclohexanecarboxylic acid, 3-((2-methyl-6-(1-methyl-5-((((methylpropylamino)carbonyl)oxy)methyl)-1H-1,2,3-triazol-4-yl)-3-pyridinyl)oxy)-, (1S,3S)-. Grade: ≥95%. CAS No. 2170126-74-4. Molecular formula: C22H31N5O5. Mole weight: 445.51. | |
| COF&Tetrakis(4-ethynylphenyl)ethane | COF&Tetrakis(4-ethynylphenyl)ethane. Group: Alkyne organic linkers-4d-alkyne organic linkers. Pack Sizes: 500 mg. Product ID: 1-ethynyl-4-[1,2,2-tris(4-ethynylphenyl)ethenyl]benzene. Molecular formula: 428.5g/mol. Mole weight: C34H20. InChI=1S/C34H20/c1-5-25-9-17-29 (18-10-25)33 (30-19-11-26 (6-2)12-20-30)34 (31-21-13-27 (7-3)14-22-31)32-23-15-28 (8-4)16-24-32/h1-4, 9-24H. LPAXHPNUGIPWEA-UHFFFAOYSA-N. | |
| DBIBB | DBIBB is a non-lipid agonist of LPA2 (EC50 = 0.10 μM) that is a G protein-coupled receptor which plays roles in protecting against radiation-induced cell death and it has no effect at other LPA receptor subtypes. Synonyms: 2-[[[4-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)butyl]amino]sulfonyl]-benzoic acid. Grade: ≥98%. CAS No. 1569309-92-7. Molecular formula: C23H20N2O6S. Mole weight: 452.5. | |
| GRI 977143 | GRI 977143 is a selective and non-lipid agonist of lysophosphatidic acid 2 (LPA2) receptor (EC50 = 3.3 μM) exhibiting no activity for other LPA GPCRs at concentrations up to 10 μM. GRI 977143 inhibits activation of caspases 3, 7, 8 and 9, Bax translocation and PARP-1 cleavage. It also activates ERK1/2 survival pathway. Synonyms: GRI977143; GRI-977143; GRI 977143; 2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid. Grade: ≥98% by HPLC. CAS No. 325850-81-5. Molecular formula: C22H17NO4S. Mole weight: 391.44. | |
| H2L5186303 | H2L5186303 is a potent and selective lysophosphatidic acid 2 (LPA2) receptor antagonist (IC50 = 8.9, 1230 and 27354 nM for LPA2, LPA3 and LPA1 receptors respectively, in a LPA-elicited calcium mobilization assay). Synonyms: H2L5186303; H2L 5186303; H2L-5186303; (Z,Z)-4,4'-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid. Grade: ≥98% by HPLC. CAS No. 139262-76-3. Molecular formula: C26H20N2O8. Mole weight: 488.45. | |
| H2L 5765834 | H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA1, LPA3, and LPA5, with IC50s of 94, 752, and 463 nM respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 420841-84-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15706. | |
| H2L 5765834 | H2L 5765834 is an antagonist of the lysophosphatidic acid receptors LPA1, LPA5 and LPA3 (IC50 = 94, 463 and 752 nM, respectively). H2L 5765834 may be used for the treatment of systemic sclerosis. Uses: Potential treatment of systemic sclerosis. Synonyms: H2L 5765834; H2L5765834; H2L-5765834; 2,3-Dihydro-2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxo-1H-isoindole-5-carboxylic acid; 2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxoisoindole-5-carboxylic acid. Grade: ≥99% by HPLC. CAS No. 420841-84-5. Molecular formula: C21H12N2O7. Mole weight: 404.33. | |
| HA-155 | HA-155 is an autotaxin inhibitor. Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase 2 (NPP2 or ENPP2), is a secreted enzyme converting lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA), which is responsible for tumor cell motility stimulation. Synonyms: HA 155; HA155; Autotaxin Inhibitor IV; Boronic acid, B-[4-[[4-[[3-[(4-fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-. Grade: ≥95%. CAS No. 1229652-22-5. Molecular formula: C24H19BFNO5S. Mole weight: 463.3. | |
| Ki16425 | Ki16425 (Debio 0719) is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with K i s of 0.34 μM and 0.93 μM, respectively. Ki16425 (Debio 0719) reduces the LPA -induced activation of p42/p44 MAPK [1] [2]. Ki16425 can also inhibit LPA -induced dephosphorylation of Yes-associated protein (YAP)/TAZ in HEK293A cells [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Debio 0719. CAS No. 355025-24-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13285. | |
| Leu-Pro-Ala-NH2 | Leu-Pro-Ala-NH2 is a simple tripeptide with a free amine group at the C-terminus. It consists of leucine (Leu), proline (Pro), and alanine (Ala) residues. The -NH2 at the C-terminus indicates that the peptide has a free amine group, which can be utilized for further reactions or modifications. This peptide sequence is used to study the effects of leucine, proline, and alanine in peptide structures and interactions, with potential applications in understanding peptide conformations or biological activities. Synonyms: LPA; H-Leu-Pro-Ala-NH2; (S)-1-(L-Leucyl)-N-((S)-1-amino-1-oxopropan-2-yl)pyrrolidine-2-carboxamide. Grade: ≥95%. Molecular formula: C14H26N4O3. Mole weight: 298.39. | |
| ONO-0740556 | ONO-0740556 is a potent Gi-coupled human lysophosphatidic acid receptor 1 (LPA1) agonist with an EC50 value of 0.26 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2250210-69-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-150204. | |
| ONO-9780307 | ONO-9780307 is a specific synthetic LPA1 (lysophosphatidic acid receptor 1) antagonist with an IC50 value of 2.7 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 856691-44-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117444. | |
| PD 128042 | PD 128042 (CI 976) is a potent, orally active, and selective inhibitor of ACAT (acyl coenzyme A:cholesterol acyltransferase) with an IC50s of 73 nM. PD 128042 is also a potent LPAT (lysophospholipid acyltransferase) inhibitor. PD 128042 inhibits Golgi-associated LPAT activity (IC50=15 ?M). PD 128042 inhibits multiple membrane trafficking steps, including ones found in the endocytic and secretory pathway[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CI 976. CAS No. 114289-47-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107572. | |
| Phosphoric Acid, Diammonium Salt, ACS | Diammonium salt of Phosphoric Acid, used in various chemical processes as a phosphorylating compound. Also used in the preparation of prosthetics and collagen nanocomposites due to the bone-like properties. Group: Biochemicals. Alternative Names: Akoustan A; Ammonium Dibasic Phosphate; Ammonium Hydrogen Phosphate; Ammonium Hydrogen Phosphate ((NH4)2HPO4); Ammonium Monohydrogen Orthophosphate; Ammonium Monohydrogen Phosphate; Ammonium Orthophosphate Dibasic; Ammonium Phosphate ((NH4)2(HPO4)); Ammonium Phosphate Dibasic; Coaltrol LPA 445; DAP; Diammonium Acid Phosphate; Diammonium Hydrogen Orthophosphate; Diammonium Hydrogen Phosphate; Diammonium Hydrogen Phosphate ((NH4)HPO4); Diammonium Monohydrogen Phosphate; Diammonium Orthophosphate; Diammonium Phosphate; Dibasic Ammonium Phosphate; Hydrogen Diammonium Phosphate; K 2; K 2 (phosphate); Pelor; Phos-Chek 202A; Pyrozyl WAR; Secondary Ammonium Phosphate; Spartan AR 295. Grades: ACS Grade. CAS No. 7783-28-0. Pack Sizes: 10g, 25g, 50g, 100g. Molecular Formula: H9N2O4P, Molecular Weight: 132.06. US Biological Life Sciences. | Worldwide |
| Poly(acrylamide/acrylic acid)[60:40],mw >10,000,000 | Poly(acrylamide/acrylic acid)[60:40],mw >10,000,000. Uses: Polyacrylamides are a family of high molecular weight, water-soluble polymers. anionic polyacrylamides (apams) are used in the construction field as a thickener or flocculent. polyacrylamides (pams) are used to increase the dry strength of papers by hydrogen bonding. used in film forming; antistatic. Additional or Alternative Names: LINEAR POLYACRYLAMIDE;AQUACIDE IV;GENELUTE(TM)-LPA;ACRYLAMIDE POLYMER;ACRYLAMIDE RESIN;POLYACRYLAMIDE RESIN;POLY(ACRYLAMIDE/ACRYLIC ACID NA SALT);SPAR-50. Product Category: Polymer/Macromolecule. CAS No. 25085-02-3. Molecular formula: #REF! Mole weight: >10,000,000. Density: 1.14. Product ID: ACM25085023. Alfa Chemistry ISO 9001:2015 Certified. |  |
| SET2 | SET2 is a selective TRPV2 antagonist ( IC 50 =0.46 μM). SET2 blocks the TRP channel and suppresses prostate cancer cells migration. SET2 reduces the lysophosphatidic acid (LPA, a TRPV2 activator)-induced cytoplasmic calcium increases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2313525-20-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132222. | |
| (Z)-HA-155 | HA-155 is an autotaxin inhibitor. Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase 2 (NPP2 or ENPP2), is a secreted enzyme converting lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA), which is responsible for tumor cell motility stimulation. Synonyms: (Z)-HA 155; (Z)-HA155; Boronic acid, B-[4-[[4-[[3-[(4-fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-. Grade: >98%. CAS No. 1312201-00-5. Molecular formula: C24H19BFNO5S. Mole weight: 463.3. | |
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