Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| LPA1 receptor antagonist 1 | LPA1 receptor antagonist 1 is a highly selective Lysophosphatidic Acid receptor-1 (LPA1) antagonist with an IC 50 of 25 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1396006-71-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-18076. |  |
| LPA2 antagonist 1 | LPA2 antagonist 1 could block the Erk activation regulated by LPA(2) and proliferation of HCT-116 cells as a selective inhibitor of LPA2 protein. IC50: 17 nM (in vitro). It could also be used to assess the inhibiting effection in the process of anticancer. Uses: Lpa2 antagonist 1 could block the erk activation regulated by lpa(2) and proliferation of hct-116 cells as a selective inhibitor of lpa2 protein. Synonyms: LPA2 antagonist 1; CHEMBL256470; BDBM50373826; AKOS027314118; CS-3103; AK298931; MDK6664; MDK-6664; MDK 6664; LPA2-IN-1. Grades: 95%. CAS No. 1017606-66-4. Molecular formula: C20H23Cl2N5O2S2. Mole weight: 500.46. |  |
| 17:0 Cyclic LPA | 17:0 Cyclic LPA. Group: Others. Purity: >99%. Mole weight: 423.524. Stability: 1 Years. Storage: -20°C. 1-Heptadecanoyl-glycero-2,3-cyclic-phosphate (ammonium salt); 17:0 Cyclic LPA. Cat No: PHOZ-181. |  |
| 2- (2?-Di-tert-butylphosphine) biphenylpalladium (II) Acetate | 2- (2?-Di-tert-butylphosphine) biphenylpalladium (II) Acetate is a precatalyst for Buchwald-Hartwig amination reaction. It is also used to prepare anticancer LPA2 antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 577971-19-8. Pack Sizes: 100mg, 250mg. Molecular Formula: C22H29O2PPd, Molecular Weight: 462.86. US Biological Life Sciences. |  Worldwide |
| AzoLPA Ammonium salt | AzoLPA is embedded with an azobenzene photoswitch which enables the optical control of LPA receptor activation. The light-induced cis-form shows greater activation of LPA receptors than its dark-adapted trans-form. Lysophosphatidic acid (LPA) is an extracellular signaling molecule that activates LPA1-6 receptors. These receptors are particularly important in the nervous, cardiovascular, reproductive, gastrointestinal and pulmonary systems. Synonyms: 1- (E) -4- (4- ( (4-butylphenyl) diazenyl) phenyl) butanoyl]-2-hydroxy-sn-glycero-3-phosphate (ammonium salt). Grades: >99%. CAS No. 2389048-52-4. Molecular formula: C23H34N3O7P. Mole weight: 495.51. | |
| TC LPA5 4 | TC LPA5 4. Group: Biochemicals. Grades: Purified. CAS No. 1393814-38-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC LPA5 4 | TC LPA5 4 is a LPA 5 (GPR92) -specific non-lipid antagonist. TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelet (LPA 5 -RH7777 cell line) with an IC 50 of 800 nM. TC LPA5 4 displays selectivity for LPA 5 over 80 other screened agent targets [1]. TC LPA5 4 inhibits cell proliferation and migration of thyroid cancer cells [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1393814-38-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107615. | |
| TC LPA5 4 | TC LPA5 4 is a LPA5 receptor antagonist (IC50 = 0.8 μM in LPA5-RH7777 cells), displaying selectivity for LPA5 against 80 other screened targets. TC LPA5 4 was shown to inhibit LPA-induced aggregation of isolated human platelets. Synonyms: LPA5-IN-4; LPA5-IN4; LPA5IN4, TC-LPA5-4; 5-(3-Chloro-4-cyclohexylphenyl)-1-(3-methoxyphenyl)-1H-pyrazole-3-carboxylic acid. Grades: ≥98% by HPLC. CAS No. 1393814-38-4. Molecular formula: C23H23ClN2O3. Mole weight: 410.89. | |
| 1-Hexadecylglycero-3-phosphate | 1-Hexadecyl lysophosphatidic acid is an ether analog of lysophosphatidic acid (LPA) containing a hexadecyl group in the sn-1 position. LPA binds to five different G protein-coupled receptors and mediates a variety of biological responses, including cell proliferation, smooth muscle contraction, platelet aggregation, neurite contraction, and cell motility. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 1-Hex-GPA. CAS No. 52603-03-9. Pack Sizes: 1 mg. Product ID: HY-W127502. | |
| 1-Hexadecyl lysophosphatidic acid | 1-Hexadecyl lysophosphatidic acid is an ether analog of lysophosphatidic acid (LPA) containing a hexadecyl group at the sn-1 position. Synonyms: Alkyl glycero phosphate 16:0; 1-Hexadecyl-2-hydroxy-sn-glycero-3-phosphate; (3-hexadecoxy-2-hydroxypropyl) dihydrogen phosphate. Grades: ≥98%. CAS No. 52603-03-9. Molecular formula: C19H41O6P. Mole weight: 396.5. | |
| 1-Hexadecyl lysophosphatidic acid sodium salt | 1-Hexadecyl lysophosphatidic acid is an ether analog of lysophosphatidic acid (LPA) containing a hexadecyl group at the sn-1 position. Synonyms: Alkyl glycero phosphate 16:0 sodium salt; 1-Hexadecyl-2-hydroxy-sn-glycero-3-phosphate sodium salt; AGP 16:0 sodium salt. Grades: ≥98%. Molecular formula: C19H40O6P·Na. Mole weight: 418.5. | |
| 1-Octadecyl lysophosphatidic acid | 1-Octadecyl lysophosphatidic acid (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position. LPA binds to one of five different G protein linked receptors to mediate a variety of biological responses. Synonyms: 1-Octadecyl LPA; (2-hydroxy-3-octadecoxypropyl) dihydrogen phosphate. Grades: ≥95%. CAS No. 52977-29-4. Molecular formula: C21H45O6P. Mole weight: 424.6. | |
| 1-Octadecyl lysophosphatidic acid sodium salt | 1-Octadecyl lysophosphatidic acid (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position. LPA binds to one of five different G protein linked receptors to mediate a variety of biological responses. Synonyms: 1-Octadecyl LPA. Grades: ≥95%. Molecular formula: C21H44O6P·Na. Mole weight: 446.5. | |
| 1-Oleoyl lysophosphatidic acid | 1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) is an abundant lysophosphatidic acid (LPA) species with high biological activity due to its strong affinity for the LPA receptors. 1-Oleoyl lysophosphatidic acid is commonly used in most laboratories as a reagent for LPA receptor activation [1]. 1-Oleoyl lysophosphatidic acid increases SRE-driven β-galactosidase activity [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1-Oleoyl-sn-glycero-3-phosphate; 1-Oleoyl-LPA. CAS No. 65528-98-5. Pack Sizes: 5 mg (22.91 mM * 500 μL in Ethanol); 10 mg (22.91 mM * 1 mL in Ethanol); 25 mg (22.91 mM * 2.5 mL in Ethanol). Product ID: HY-137862. | |
| 1-Oleoyl lysophosphatidic acid | 1-Oleoyl lysophosphatidic acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of phospholipase D (PLD) or through a two step process involving liberation of diacylglycerol (DAG) by phospholipase C (PLC) followed by phosphorylation of DAG by diglycerol kinase. Synonyms: 1-Oleoyl-sn-glycerol 3-phosphate; Oleoyl LPA; 18:1 LPA; 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate; LysoPA(18:1). Grades: ≥95%. CAS No. 65528-98-5. Molecular formula: C21H41O7P. Mole weight: 436.50. | |
| 1-Oleoyl lysophosphatidic acid sodium | 1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) sodium, a potent bioactive phospholipid, is a LPA receptor activator. 1-Oleoyl lysophosphatidic acid sodium can promote mitosis by inducing DNA synthesis. 1-Oleoyl lysophosphatidic acid sodium is also involved in normal and pathological emotional responses, including anxiety and depression [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1-Oleoyl-sn-glycero-3-phosphate sodium; 1-Oleoyl-LPA sodium. CAS No. 325465-93-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107614. | |
| 1-Oleoyl lysophosphatidic acid sodium salt | 1-Oleoyl lysophosphatidic acid sodium salt is lysophospholipid receptor (LPA1 and LPA2) agonist. It can inhibit differentiation of neural stem cells into neurons. Synonyms: 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoricacid sodium salt; 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate (sodium salt); PA(18:1(9Z)/0:0) (sodium salt); 1-Oleoyl lysophosphatidic acid sodium salt. Grades: >99%. CAS No. 325465-93-8. Molecular formula: C21H40NaO7P. Mole weight: 458.50. | |
| 1-Oleoyl lysophosphatidic acid sodium salt | Endogenous agonist of the lysophospholipid receptors LPA1 and LPA2. Inhibits differentiation of neural stem cells (NSCs) into neurons.CAS Number:325465-93-8. Group: Biochemicals. Grades: Purified. CAS No. 325465-93-8. Pack Sizes: 1mg. Molecular Formula: C21H40NaO7P. US Biological Life Sciences. | Worldwide |
| 1-Oleoyl Lysophosphatidic Acid (Sodium Salt) | 1-Oleoyl Lysophosphatidic Acid is a lysophophatidic acid (LSA) with oleic acid in the sn-1 position that is an endogenous agonist for LPA1 and LPA2 receptors. It is reported to inhibit the differentiation of neural stem cells into neurons and is involved in multiple biological activities such as smooth muscle contraction, platelet aggregation, cell proliferation, cell migration, and calcium mobilization. 1-Oleoyl Lysophosphatidic Acid is commonly used for growth stimulation in a variety of cell lines. Group: Biochemicals. Alternative Names: 9-Octadecenoicacid (9Z)-, 2-hydroxy-3-(phosphonooxy)propyl ester, 1-Oleoyl-sn-glycerol 3-phosphate sodium salt, 1-oleoyl sodium salt, LPA sodium salt. Grades: Highly Purified. CAS No. 22556-62-3. Pack Sizes: 10mg. Molecular Formula: C21H40O7, Molecular Weight 458.5. US Biological Life Sciences. | Worldwide |
| 1-Palmitoyl lysophosphatidic acid | 1-Palmitoyl lysophosphatidic acid (1-Palmitoyl LPA) is a LPA analog containing palmitic acid at the sn-1 position. LPA binds to one of at least five different G protein-coupled receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. Synonyms: 1-Palmitoyl LPA; 1-Palmitoylglycerol 3-phosphate. Grades: ≥98%. CAS No. 22002-85-3. Molecular formula: C19H39O7P. Mole weight: 410.5. | |
| 2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]butyric Acid Ethyl Ester | 2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]butyric Acid Ethyl Ester is used as a reagent to prepare N-heterocyclylcarbamates and biphenylisoxazoles as lysophosphatidic acid (LPA) receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 1282659-60-2. Pack Sizes: 250mg, 2.5g. Molecular Formula: C18H27BO4, Molecular Weight: 318.22. US Biological Life Sciences. | Worldwide |
| 2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]butyric Acid Ethyl Ester-d5 | 2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]butyric Acid Ethyl Ester-d5 is labelled 2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]butyric Acid Ethyl Ester (T302660) which is used as a reagent to prepare N-heterocyclylcarbamates and biphenylisoxazoles as lysophosphatidic acid (LPA) receptor antagonists. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 100mg. Molecular Formula: C18H22D5BO4, Molecular Weight: 323.25. US Biological Life Sciences. | Worldwide |
| 2-Fluoro-4-hydroxymethylphenol | 2-Fluoro-4-hydroxymethylphenol is used in preparation of fused imidazopyrimidinones that act as Lp-LPA2 inhibitors and also used to synthesize bicyclic inhibitors of acety-CoA carboxylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 96740-93-1. Pack Sizes: 100mg, 250mg. Molecular Formula: C7H7FO2, Molecular Weight: 142.13. US Biological Life Sciences. | Worldwide |
| (2S)-OMPT (ammonium salt) | OMPT is a selective agonist of the lysophosphatidic acid 3 (LPA3) receptor. It exhibits EC50 values of 68 nM and >6.8 μM for calcium mobilization in LPA3 and LPA2-expressing Sf9 cells, respectively. Synonyms: (2S)-2-methoxy-3-(thiophosphonooxy)propyl (9Z)-octadec-9-enoate (ammonium salt); 2(S)-OMPT (ammonium salt); 1-oleoyl-2-methyl-sn-glycero-3-phosphothionate (ammonium salt). Grades: >99%. CAS No. 645408-61-3. Molecular formula: C22H46NO6PS. Mole weight: 483.64. | |
| 2-((tert-Butyldimethylsilyloxy)methyl)furo[3,2-b]pyridine-6-carboxylic acid | 2-((tert-Butyldimethylsilyloxy)methyl)furo[3,2-b]pyridine-6-carboxylic acid. Group: Salt. Alternative Names: 2-((tert-Butyldimethylsilyloxy)methyl)-furo[3,2-b]pyridine-6-carboxylic acid, 1171920-49-2, 2-((tert-Butyldimethylsilyloxy)methyl)furo[3,2-b]pyridine-6-carboxylic acid, 2-(((tert-Butyldimethylsilyl)oxy)methyl)furo[3,2-b]pyridine-6-carboxylic acid, 2-{[(tert-butyldimethylsilyl)oxy]methyl}furo[3,2-b]pyridine-6-carboxylic acid, AC1Q1LJB, CTK7J0559, AKOS015837797, AG-A-27144, AK-55708, A-6083. CAS No. 1171920-49-2. Product ID: 2-[[tert-butyl (dimethyl)silyl]oxymethyl]furo[3, 2-b]pyridine-6-carboxylic acid. Molecular formula: 307.42. Mole weight: C15< / sub>H21< / sub>NO4< / sub>Si. LPAAHOPBWVHPDY-UHFFFAOYSA-N. 96%. |  |
| 4-Tetradecanamidobenzylphosphonic Acid | S32826 is a potent and selective inhibitor of autotaxin. Autotaxin catalyzes the transformation of lyso-phosphatidylcholine in lyso-phosphatidic acid (LPA). S32826 inhibits LPA release from adipocytes (IC50 = 90 nM) and reduces plasma autotaxin activity. Synonyms: 4-Tetradecanamidobenzylphosphonic acid. Grades: ≥98%. CAS No. 1096770-84-1. Molecular formula: C21H36NO4P. Mole weight: 397.5. | |
| AM095 | AM095, an effective LPA1 receptor antagonist, has been found to decrease dermal fibrosis caused by attenuates bleomycin. IC50: 0.98 uM and 0.73 uM for human and mouse LPA1 respectively. Synonyms: AM095 (free acid); AM-095; AM 095. Grades: 98%. CAS No. 1228690-36-5. Molecular formula: C27H24N2O5. Mole weight: 456.49. | |
| AM095 | AM095 is a selective LPA 1 receptor antagonist. The IC 50 for AM095 antagonism of LPA-induced calcium flux of human or mouse LPA 1 -transfected CHO cells is 0.025 and 0.023 μM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1345614-59-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-16039. | |
| AM095 free acid | AM095 (free acid) is a potent LPA1 receptor antagonist with IC 50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1228690-36-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-16040. | |
| AM095 sodium | AM095 is a selective LPA1 receptor antagonist. The IC50 for AM095 antagonism of LPA-induced calcium flux of human or mouse LPA1-transfected CHO cells is 0.025 and 0.023 μM, respectively. Synonyms: AM-095 sodium; AM 095 sodium. Grades: >98%. CAS No. 1345614-59-6. Molecular formula: C27H23N2NaO5. Mole weight: 478.48. | |
| AM 966 | AM966, a LPA1 receptor antagonist, has been found to restrain lung fibrosis in mouse model. IC50: 17 nM. Uses: Am966 is a lpa1 receptor antagonist that has been found to restrain lung fibrosis in mouse model. Synonyms: AM-966; AM 966; AM966; 2-[4-[4-[4-[[(1R)-1-(2-chlorophenyl)ethoxy]carbonylamino]-3-methyl-1,2-oxazol-5-yl]phenyl]phenyl]aceticacid;AM966;AM-966;UNII-CEO54NH393;1228690-19-4;(R)-2-(4'-(4-(((1-(2-Chlorophenyl)ethoxy)carbonyl)amino)-3-methylisoxazol-5-yl)-[1,1'-biphenyl]-4-yl)acet. Grades: 95%. CAS No. 1228690-19-4. Molecular formula: C27H23ClN2O5. Mole weight: 490.93. | |
| (-)-AS 115 | (-)-AS 115, an isomer of AS 115, is a potent and selective inactivator of KIAA1363. KIAA1363 is an enzyme that catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network. Synonyms: (-)-AS 115; CHEMBL2069333; ()-AS 115; 2-Fluorophenyl- (2- ( ( (1R, 2S) -2- (butoxymethyl) cyclohexyl) methoxy) ethyl) carbamate; AS 115; AS115; BDBM50390508. Grades: ≥98%. CAS No. 926657-43-4. Molecular formula: C21H32FNO4. Mole weight: 381.5. | |
| Autotaxin Inhibitor III, PF-8380 (Atx Inhibitor III, PF-8380, 6-(3-(Piperazin-1-yl)propanoyl)-benzo[d]oxazol-2(3H)-one) | An orally bioavailable piperazinyl benzoxazolone compound that acts as a substrate competitive and tight-binding inhibitor of autotaxin activity {IC50=2.8 and 1.7nM for recombinant human enzyme-b isoform employing FS-3 and LPC (lysophosphatidyl choline) as substrates, respectively; 1.16 and 1.15nM for rat/murine enzyme-FS-3 and fetal fibroblast cell-LPC; 101nM for human whole blood}. Displays desirable pharmacokinetics properties and efficiently blocks inflammation-induced LPA (lysophosphatidic acid) production both in plasma and at the site of inflammation by 95% in rat adjuvant-induced arthritis model (30mg/kg, p.o.).CAS No:1144035-53-9. Group: Biochemicals. Grades: Highly Purified. CAS No. 1144035-53-9. Pack Sizes: 10mg. Molecular Formula: C??H??Cl?N?O?. US Biological Life Sciences. | Worldwide |
| BI-2545 | BI-2545 is a potent autotaxin (ATX) inhibitor that significantly reduces LPA, with IC 50 s of 2.2 nM and 3.4 nM for human ATX and rat ATX, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2162961-71-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124772. | |
| Bioactive Lipid Compound Library | A unique collection of 385 bioactive lipids related compounds for high throughput screening (HTS) and high content screening (HCS), including Agonists & Antagonists, Endocannabinoids, Farnesyl/geranylgeranyl derivates, HETEs deHETEs, hepoxilins, Polyunsaturated fatty acids, Leukotrienes, lipoxins, LPA & phosphatidic acids, Octadecanoids, PAFs, Prostaglandins & thromboxanes, Retinoids, vitamin D metabolites, Sphingolipids, etc. ; - Targets include GPCR, HDAC, PPAR, DNA Alkylating, EGFR, etc. ; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L7000. Categories: Bioactive Lipid Compounds Libraries. |  |
| BMP-22 | BMP-22 is an inhibitor of autotaxin with IC50 of 170 nM. It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM. BMP-22 inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC) in vitro in a concentration-dependent manner. MP-22 can decrease the number of lung metastatic foci in a B16/F10 syngeneic mouse melanoma model of lung metastasis. Synonyms: 4-pentadecylbenzylphosphonic acid; BMP22; BMP 22. Grades: ≥95%. CAS No. 1306684-90-1. Molecular formula: C22H39O3P. Mole weight: 382.52. | |
| BMS-002 | BMS-002 is a selective antogonist of lysophosphatidic acid (LPA) receptor-1 developed to treat diabetic nephropathy. In eNOS-/- db/db mouse model, BMS-002 significantly decreased the level of proteinuria. Uses: The potential treatment of diabetic nephropathy. Synonyms: BMS 002; BMS002. | |
| BMS 986020 | BMS 986020 is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist with an IC50 value less than 300 nM for human LPA1 expressing CHO cells. It inhibits bile acid and phospholipid transporters with IC50s of 4.8 μM, 6.2 μM, and 7.5 μM for BSEP, MRP4, and MDR3, respectively. BMS 986020 is used for the treatment of idiopathic pulmonary fibrosis (IPF). Synonyms: BMS-986020; BMS986020. Grades: ≥98%. CAS No. 1257213-50-5. Molecular formula: C29H26N2O5. Mole weight: 482.5. | |
| BMS-986278 | BMS-986278 is a potent and orally active lysophosphatidic acid receptor 1 (LPA1) antagonist, with K b s of 6.9 nM and 4.0 nM for human and mouse LPA1, respectively. BMS-986278 can be used for the research of pulmonary fibrotic diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2170126-74-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139853. | |
| COF&Tetrakis(4-ethynylphenyl)ethane | COF&Tetrakis(4-ethynylphenyl)ethane. Group: Alkyne organic linkers-4d-alkyne organic linkers. Pack Sizes: 500 mg. Product ID: 1-ethynyl-4-[1,2,2-tris(4-ethynylphenyl)ethenyl]benzene. Molecular formula: 428.5g/mol. Mole weight: C34H20. InChI=1S/C34H20/c1-5-25-9-17-29 (18-10-25)33 (30-19-11-26 (6-2)12-20-30)34 (31-21-13-27 (7-3)14-22-31)32-23-15-28 (8-4)16-24-32/h1-4, 9-24H. LPAXHPNUGIPWEA-UHFFFAOYSA-N. | |
| DBIBB | DBIBB is a non-lipid agonist of LPA2 (EC50 = 0.10 μM) that is a G protein-coupled receptor which plays roles in protecting against radiation-induced cell death and it has no effect at other LPA receptor subtypes. Synonyms: 2-[[[4-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)butyl]amino]sulfonyl]-benzoic acid. Grades: ≥98%. CAS No. 1569309-92-7. Molecular formula: C23H20N2O6S. Mole weight: 452.5. | |
| GRI 977143 | GRI 977143 is a selective and non-lipid agonist of lysophosphatidic acid 2 (LPA2) receptor (EC50 = 3.3 μM) exhibiting no activity for other LPA GPCRs at concentrations up to 10 μM. GRI 977143 inhibits activation of caspases 3, 7, 8 and 9, Bax translocation and PARP-1 cleavage. It also activates ERK1/2 survival pathway. Synonyms: GRI977143; GRI-977143; GRI 977143; 2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid. Grades: ≥98% by HPLC. CAS No. 325850-81-5. Molecular formula: C22H17NO4S. Mole weight: 391.44. | |
| H2L5186303 | H2L5186303 is a potent and selective lysophosphatidic acid 2 (LPA2) receptor antagonist (IC50 = 8.9, 1230 and 27354 nM for LPA2, LPA3 and LPA1 receptors respectively, in a LPA-elicited calcium mobilization assay). Synonyms: H2L5186303; H2L 5186303; H2L-5186303; (Z,Z)-4,4'-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid. Grades: ≥98% by HPLC. CAS No. 139262-76-3. Molecular formula: C26H20N2O8. Mole weight: 488.45. | |
| H2L 5765834 | H2L 5765834 is an antagonist of the lysophosphatidic acid receptors LPA1, LPA5 and LPA3 (IC50 = 94, 463 and 752 nM, respectively). H2L 5765834 may be used for the treatment of systemic sclerosis. Uses: Potential treatment of systemic sclerosis. Synonyms: H2L 5765834; H2L5765834; H2L-5765834; 2,3-Dihydro-2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxo-1H-isoindole-5-carboxylic acid; 2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxoisoindole-5-carboxylic acid. Grades: ≥99% by HPLC. CAS No. 420841-84-5. Molecular formula: C21H12N2O7. Mole weight: 404.33. | |
| HA-155 | HA-155 is an autotaxin inhibitor. Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase 2 (NPP2 or ENPP2), is a secreted enzyme converting lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA), which is responsible for tumor cell motility stimulation. Synonyms: HA 155; HA155; Autotaxin Inhibitor IV; Boronic acid, B- [4- [ [4- [ [3- [ (4-fluorophenyl) methyl] -2, 4-dioxo-5-thiazolidinylidene] methyl] phenoxy] methyl] phenyl] -. Grades: ≥95%. CAS No. 1229652-22-5. Molecular formula: C24H19BFNO5S. Mole weight: 463.3. | |
| Ki16198 | Ki16198, the methyl ester of Ki16425, is a potent and orally active LPA receptor antagonist with Kis of 0.34 and 0.93 μM against inositol phosphate production induced by LPA1 and LPA3, respectively. It is effective for pancreatic cancer tumorigenesis and metastasis in vivo. Synonyms: 3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonylamino)-3-methyl-5-isoxazolyl)benzylsulfanyl)propanoic acid methyl ester; Propanoic acid, 3-[[[4-[4-[[[1-(2-chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]-, methyl ester; KI-16198; KI 16198; Methyl 3-((4-(4-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-3-methylisoxazol-5-yl)benzyl)thio)propanoate. Grades: >98%. CAS No. 355025-13-7. Molecular formula: C24H25ClN2O5S. Mole weight: 488.98. | |
| Ki16425 | Ki16425 (Debio 0719) is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with K i s of 0.34 μM and 0.93 μM, respectively. Ki16425 (Debio 0719) reduces the LPA -induced activation of p42/p44 MAPK [1] [2]. Ki16425 can also inhibit LPA -induced dephosphorylation of Yes-associated protein (YAP)/TAZ in HEK293A cells [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Debio 0719. CAS No. 355025-24-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13285. | |
| Ki16425 | Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively, shows no activity at LPA4, LPA5, LPA6. Synonyms: Ki16425; Ki-16425; Ki 16425. Grades: >98%. CAS No. 355025-24-0. Molecular formula: C23H23ClN2O5S. Mole weight: 474.96. | |
| ONO-7300243 | ONO-7300243 is a novel, potent LPA1 (Lysophosphatidic Acid Receptor) antagonist (IC50 = 160 nM). In vitro ONO-7300243 showed good membrane permeability and good metabolic stability against rat liver microsomes. ONO-7300243 shows good efficacy in vivo. Synonyms: 2-[4-[[ (3, 5-dimethoxy-4-methylbenzoyl) - (3-phenylpropyl) amino]methyl]phenyl]acetic acid; ONO-7300243; ONO 7300243; ONO7300243. Grades: 99.52 %. CAS No. 638132-34-0. Molecular formula: C28H31NO5. Mole weight: 461.55. | |
| Palmitoleoyl 3-carbacyclic phosphatidic acid | Palmitoleoyl 3-carbacyclic phosphatidic acid is a cyclic LPA analog containing the 16:1 fatty acid, palmitoleate, at the sn-1 position of the glycerol backbone. At 25 μM, it inhibits the transcellular migration of MM1 cells across mesothelial cell monolayers in response to fetal bovine serum (86.9%) or LPA (99.9%) without affecting proliferation. It has been shown to inhibit autotaxin (IC50 = 620 nM). Synonyms: 3-carbacyclic PA; 3-ccPA 16:1. Grades: ≥95%. CAS No. 910228-13-6. Molecular formula: C20H37O5P. Mole weight: 388.5. | |
| Palmitoyl 3-carbacyclic phosphatidic acid | Palmitoyl 3-carbacyclic phosphatidic acid is a cyclic LPA analog containing the 16:0 fatty acid, palmitate, at the sn-1 position of the glycerol backbone. At 25 μM, it inhibits the transcellular migration of MM1 cells across mesothelial cell monolayers in response to fetal bovine serum (81.9%) or LPA (98.9%) without affecting proliferation. It has been shown to inhibit autotaxin (IC50 = 620 nM). Synonyms: 3-ccPA 16:0. Grades: ≥95%. CAS No. 476310-22-2. Molecular formula: C20H39O5P. Mole weight: 390.5. | |
| PF-8380 | PF-8380 blocks inflammation-induced LPA synthesis. PF-8380 works both in vitro and in vivo through direct inhibition of autotaxin. In human whole blood PF-8380 inhibited autotaxin with an IC50 of 101 nM. Inhibition of ATX by PF-8380 led to decreased invasion and enhanced radiosensitization of GBM cells. Radiation-induced activation of Akt was abrogated by inhibition of ATX. Furthermore, inhibition of ATX led to diminished tumor vascularity and delayed tumor growth. PF-8380 can serve as a tool compound for elucidating LPA's role in inflammation. Synonyms: 1-Piperazinecarboxylic acid, 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-, (3,5-dichlorophenyl)methyl ester; PF8380; PF 8380; (3,5-Dichlorophenyl)methyl 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-1-piperazinecarboxylate; 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester. Grades: ≥95%. CAS No. 1144035-53-9. Molecular formula: C22H21Cl2N3O5. Mole weight: 478.33. | |
| Phosphoric Acid, Diammonium Salt, ACS | Diammonium salt of Phosphoric Acid, used in various chemical processes as a phosphorylating compound. Also used in the preparation of prosthetics and collagen nanocomposites due to the bone-like properties. Group: Biochemicals. Alternative Names: Akoustan A; Ammonium Dibasic Phosphate; Ammonium Hydrogen Phosphate; Ammonium Hydrogen Phosphate ((NH4)2HPO4); Ammonium Monohydrogen Orthophosphate; Ammonium Monohydrogen Phosphate; Ammonium Orthophosphate Dibasic; Ammonium Phosphate ((NH4)2(HPO4)); Ammonium Phosphate Dibasic; Coaltrol LPA 445; DAP; Diammonium Acid Phosphate; Diammonium Hydrogen Orthophosphate; Diammonium Hydrogen Phosphate; Diammonium Hydrogen Phosphate ((NH4)HPO4); Diammonium Monohydrogen Phosphate; Diammonium Orthophosphate; Diammonium Phosphate; Dibasic Ammonium Phosphate; Hydrogen Diammonium Phosphate; K 2; K 2 (phosphate); Pelor; Phos-Chek 202A; Pyrozyl WAR; Secondary Ammonium Phosphate; Spartan AR 295. Grades: ACS Grade. CAS No. 7783-28-0. Pack Sizes: 10g, 25g, 50g, 100g. Molecular Formula: H9N2O4P, Molecular Weight: 132.06. US Biological Life Sciences. | Worldwide |
| Poly(acrylamide/acrylic acid)[60:40],mw >10,000,000 | Polyacrylamides are a family of high molecular weight, water-soluble polymers. Anionic polyacrylamides (aPAMs) are used in the construction field as a thickener or flocculent. Polyacrylamides (PAMs) are used to increase the dry strength of papers by hydrogen bonding. Used in Film forming; Antistatic. Group: Polymer/macromolecule. Alternative Names: LINEAR POLYACRYLAMIDE;AQUACIDE IV;GENELUTE(TM)-LPA;ACRYLAMIDE POLYMER;ACRYLAMIDE RESIN;POLYACRYLAMIDE RESIN;POLY(ACRYLAMIDE/ACRYLIC ACID NA SALT);SPAR-50. CAS No. 25085-02-3. Mole weight: >10,000,000. Density: 1.14. Catalog: ACM25085023. |  |
| Ro 6842262 | Ro 6842262 is a potent LPA1 antagonist (IC50 = 25 nM) with >1,200-fold selectivity for LPA1 over LPA3. Synonyms: RO-6842262;RO 6842262; RO6842262; 1-[4'-[4-Methyl-5-[[[(1R)-1-phenylethoxy]carbonylamino]-1H-1,2,3-triazol-1-yl][1,1'-biphenyl]-4-yl]cyclopropanecarboxylic acid. Grades: ≥98% by HPLC. CAS No. 1396006-71-5. Molecular formula: C28H26N4O4. Mole weight: 482.53. | |
| S 32826 | S 32826 is an autotaxin inhibitor (IC50 = 9 nM) exhibiting similar inhibitory effects at all three autotaxin isoforms (α, β and γ). S 32826 displays no affinity for lysophosphatidic acid receptor 1 (LPA1) at concentrations up to 10 μM. It inhibits LPA release from adipocytes (IC50 = 90 nM). Synonyms: S32826; S-32826; S 32826; [4- (Tetradecanoylamino) benzyl]phosphonic acid disodium salt. Grades: ≥98% by HPLC. CAS No. 1103672-43-0. Molecular formula: C21H34NO4PNa2. Mole weight: 441.45. | |
| SET2 | SET2 is a selective TRPV2 antagonist ( IC 50 =0.46 μM). SET2 blocks the TRP channel and suppresses prostate cancer cells migration. SET2 reduces the lysophosphatidic acid (LPA, a TRPV2 activator)-induced cytoplasmic calcium increases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2313525-20-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132222. | |
| Tetradecyl phosphonate | Tetradecyl phosphonate is a pan-antagonist of lysophosphatidic acid 1 (LPA1), LPA2, and LPA3 receptors with IC50 values of 10 μM, 5.5 μM, and 3.1 μM for inhibition of LPA-induced calcium mobilization, respectively. Synonyms: Tetradecylphosphonic acid; 1-Tetradecanephosphonic acid; n-Tetradecylphosphonic acid. Grades: ≥98%. CAS No. 4671-75-4. Molecular formula: C14H31O3P. Mole weight: 278.4. | |
| UNC 3230 | UNC 3230 is a potent and selective PIP5K1C inhibitor (IC50 = 41 nM), displaying selectivity for PIP5K1C over PIP5K1A, the PI 3-kinase family and a panel of other kinases. UNC 3230 decreases PIP2 levels and LPA-induced calcium signaling in dorsal root ganglia (DRG) neurons in vitro. UNC 3230 exhibits antinociceptive effects in mouse models of chronic pain. Synonyms: UNC3230; UNC-3230; UNC 3230; 5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide. Grades: ≥99% by HPLC. CAS No. 1031602-63-7. Molecular formula: C17H20N4O2S. Mole weight: 344.43. | |
| Vedolizumab | Vedolizumab is a monoclonal antibody developed by Millennium Pharmaceuticals for the treatment of ulcerative colitis and Crohn's disease under the trade name Entyvio. Vedolizumab binds to integrin α4β7 (LPAM-1) and blocks α4β7, displaying anti-inflammatory activity. Uses: The treatment of ulcerative colitis and crohn's disease. Synonyms: Entyvio. CAS No. 943609-66-3. Molecular formula: C6528H10072N1732O2042S42. Mole weight: 146836.67. | |
Our database is helping our users find suppliers everyday.
