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| Product | Description | |
|---|---|---|
| Maytansine | Maitansine, a cytotoxic agent, inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site. Synonyms: NSC153858; NSC-153858; NSC 153858; (14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-acetyl-N-methyl-L-alaninate. Grade: ≥95%. CAS No. 35846-53-8. Molecular formula: C34H46ClN3O10. Mole weight: 692.2. |  |
| Maytansine | Maytansine is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations [1]. Uses: Scientific research. Group: Natural products. Alternative Names: NSC 153858. CAS No. 35846-53-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-13674. |  |
| (2'R)-N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine | (2'R)-N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine is an epimer of N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine (D199035), which is an active metabolite of Maytansine (M197940), inhibits in vitro polymerization of tubulin and is used in the treatment of advanced breast cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 936481-23-1. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C36H50ClN3O10S. US Biological Life Sciences. |  Worldwide |
| N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine | N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine. Group: Biochemicals. Alternative Names: Mertansine, DM 1; Maytansinoid DM 1. Grades: Highly Purified. CAS No. 139504-50-0. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C35H48ClN3O10S. US Biological Life Sciences. | Worldwide |
| N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine | N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine. Group: Biochemicals. Alternative Names: DM4. Grades: Highly Purified. CAS No. 796073-69-3. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C38H54ClN3O10S. US Biological Life Sciences. | Worldwide |
| Ansamitocin P3 | Ansamitocin P-3 is a metabolite of Ansamitocin which is a new maytansinoid antitumor antibiotic. Fungal metabolite with antineoplastic, antimitotic activity. Binds to tubulin and inhibits vinblastine-induced spiral formation. Group: Biochemicals. Alternative Names: 3-O-De[2-(acetylmethylamino)-1-oxopropyl]-3-O-(1-oxobutyl)-maytansine; 4, 24-Dioxa-9, 22-diazatetracyclo[19. 3. 1. 110, 14. 03, 5]hexacosane, maytansine deriv.; Ansamitocin P 3; Antibiotic C 15003P3; Maytansinol Butyrate. Grades: Purified. CAS No. 66547-09-9. Pack Sizes: 25mg, 50mg, 100mg, 250mg. Molecular Formula: C32H43CIN2O9, Molecular Weight: 635.14. US Biological Life Sciences. | Worldwide |
| Ansamitocin P 3' | Ansamitocin P 3' is an isomer of Ansamitocin P-3, a potent anti-tumor maytansinoid antibiotic found in Actinosynnema pretiosum, a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29. Uses: Adcs cytotoxin. Synonyms: Ansamitocin P3'; AP-3'; Ansamitocin P-3'; Maytansinol butyrate, Maytansinoid AP-3'. Antibiotic C 15003P3'; iso-Ansamitocin P-3. Grade: >98%. CAS No. 66547-09-9. Molecular formula: C32H43ClN2O9. Mole weight: 635.14. | |
| Ansamitocin P-3 | It is produced by the strain of Nocardia sp. C-15003(N-1). It has the function of anti-tumor, anti-plant pathogenic fungi, skin fungi and protozoa, and has no antibacterial activity. Uses: Inhibitor of tublin spiralization,maytansine analog. Synonyms: 3-O-De[2-(acetylmethylamino)-1-oxopropyl]-3-O-(1-oxobutyl)-maytansine; 4,24-Dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosane; maytansine deriv.; Ansamitocin P 3; Antibiotic C 15003P3; Maytansinol Butyrate. Grade: ≥90% by HPLC. CAS No. 66584-72-3. Molecular formula: C32H43N2O9Cl. Mole weight: 635.14. | |
| Ansamitocin PHO-0 | It is produced by the strain of Streptamyces sclerotialus, Str. flavochromogenes, Str. flaviscleroticus, Str. luridus, Chainia nigra, Strertosporangium roseurn, Nocardia sp. N-1231. It has antiprotozoal and antitumor activity. Synonyms: Maytansine, 3-O-de[2-(acetylmethylamino)-1-oxopropyl]-15-hydroxy-, (15R)-; (15R)-3-O-De[2-(acetylmethylamino)-1-oxopropyl]-15-hydroxymaytansine; 4,24-Dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosane, maytansine deriv.; Antibiotic C 15003PHO0. CAS No. 79082-29-4. Molecular formula: C28H37N2O9Cl. Mole weight: 581.05. | |
| Ansamitocin PHO-1 | It is produced by the strain of Streptamyces sclerotialus, Str. flavochromogenes, Str. flaviscleroticus, Str. luridus, Chainia nigra, Strertosporangium roseurn, Nocardia sp. N-1231. It has antiprotozoal and antitumor activity. Synonyms: Maytansine, 3-O-acetyl-3-O-de[2-(acetylmethylamino)-1-oxopropyl]-15-hydroxy-, (15R)-; (15R)-3-O-Acetyl-3-O-de[2-(acetylmethylamino)-1-oxopropyl]-15-hydroxymaytansine; 4,24-Dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosane, maytansine deriv.; Antibiotic C 15003PHO1. CAS No. 79056-16-9. Molecular formula: C30H39N2O10Cl. Mole weight: 623.10. | |
| Ansamitocin PHO-2 | It is produced by the strain of Streptamyces sclerotialus, Str. flavochromogenes, Str. flaviscleroticus, Str. luridus, Chainia nigra, Strertosporangium roseurn, Nocardia sp. N-1231. It has antiprotozoal and antitumor activity. Synonyms: Maytansine, 2'-de(acetylmethylamino)-15-hydroxy-, (15R)-(9CI); 4,24-Dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosane, maytansine deriv.; Antibiotic C 15003PHO2. CAS No. 79028-00-5. Molecular formula: C31H41N2O10Cl. Mole weight: 637.13. | |
| Ansamitocin PHO-3 | It is produced by the strain of Streptamyces sclerotialus, Str. flavochromogenes, Str. flaviscleroticus, Str. luridus, Chainia nigra, Strertosporangium roseurn, Nocardia sp. N-1231. It has antiprotozoal and antitumor activity. Synonyms: Maytansine, 2'-de(acetylmethylamino)-15-hydroxy-2'-methyl-, (15R)-(9CI); 4,24-Dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosane, maytansine deriv.; Antibiotic C 15003PHO3. CAS No. 79082-28-3. Molecular formula: C32H43N2O10Cl. Mole weight: 651.15. | |
| Ansamitocin PHO-4 | It is produced by the strain of Streptamyces sclerotialus, Str. flavochromogenes, Str. flaviscleroticus, Str. luridus, Chainia nigra, Strertosporangium roseurn, Nocardia sp. N-1231. It has antiprotozoal and antitumor activity. Synonyms: Maytansine, 3-O-de[2-(acetylmethylamino)-1-oxopropyl]-15-hydroxy-3-O-(3-methyl-1-oxobutyl)-,(15R)-; (15R)-3-O-De[2-(acetylmethylamino)-1-oxopropyl]-15-hydroxy-3-O-(3-methyl-1-oxobutyl)maytansine; 4,24-Dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosane, maytansine deriv.; Antibiotic C 15003PHO4. CAS No. 79056-15-8. Molecular formula: C33H45N2O10Cl. Mole weight: 665.18. | |
| cantuzumab mertansine | Cantuzumab mertansine (SB-408075; huC242-DM1), an ADC, is an immunoconjugate of the potent maytansine derivative (DM1; HY-19792) and the humanized monoclonal antibody (huC242) directed to CanAg. Cantuzumab mertansine has cytotoxic toward colon cancer cells and has broad antitumor efficacy against a range of CanAg-positive human tumor xenografts. Uses: Designed for use in research and industrial production. Additional or Alternative Names: cantuzumab mertansine. Product Category: Inhibitors. CAS No. 400010-39-1. Canonical SMILES: [Cantuzumab mertansine]. Product ID: ACM400010391. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Cantuzumab mertansine | Cantuzumab mertansine (SB-408075; huC242-DM1), an ADC , is an immunoconjugate of the potent maytansine derivative ( DM1 ; HY-19792) and the humanized monoclonal antibody (huC242) directed to CanAg. Cantuzumab mertansine has cytotoxic toward colon cancer cells and has broad antitumor efficacy against a range of CanAg-positive human tumor xenografts [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: SB-408075; huC242-DM1. CAS No. 400010-39-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99492. | |
| DM1-SMe | DM1-SMe is a potent maytansinoid microtubular inhibitor and an unconjugated DM1 as a mixed disulfide with thiomethane to cap its sulfhydryl group. DM1-SMe can be readily conjugate to the SH group of an antibody to form antibody-drug conjugate (ADC). Synonyms: DM1-SMe; DM1-SSMe; maytansinoid derivative with ADC linker. Maytansine or mertansine or emtansine derivative; N2'-deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine. Grade: ≥98%. CAS No. 138148-68-2. Molecular formula: C36H50ClN3O10S2. Mole weight: 784.38. | |
| DM1-SMe | DM1-SMe is a potent maytansinoid microtubular inhibitor and an unconjugated DM1 as a mixed disulfide with thiomethane to cap its sulfhydryl group. DM1-SMe can be readily conjugate to the SH group of an antibody to form antibody-drug conjugate (ADC). Uses: Designed for use in research and industrial production. Additional or Alternative Names: DM1-SMe; DM1-SSMe; SMe-DM4,; maytansinoid derivative with ADC linker. Maytansine or mertansine or emtansine derivative; N2'-deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine. Product Category: Inhibitors. Appearance: White to off-white solid powder. CAS No. 138148-68-2. Molecular formula: C36H50ClN3O10S2. Mole weight: 784.38. Purity: >98%. IUPACName: N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine. Canonical SMILES: C[C@@H]1[C@@H]2C[C@](NC(O2)=O)(O)[C@H](OC)/C=C\C=C(C)\CC3=CC(N(C)C(C[C@@H](OC([C@@H](N(C(CCSSC)=O)C)C)=O)[C@@]4(C)C1O4)=O)=C(Cl)C(OC)=C3. Product ID: ACM138148682. Alfa Chemistry ISO 9001:2015 Certified. Categories: DMS metro station. | |
| DM1-SPP | DM1 with a reactive linker SPP, which can react with antibody to make antibody drug conjugate, as a potent EGFR inhibitor and it overcomes resistant to EGFR. Synonyms: N2'-deacetyl-N2'-[3-[[4-[(2,?5-dioxo-1-pyrrolidinyl)?oxy]?-1-methyl-4-oxobutyl]?dithio]?-1-oxopropyl]?-Maytansine; DM1 SPP. Grade: ≥98%. CAS No. 452072-20-7. Molecular formula: C44H59ClN4O14S2. Mole weight: 967.54. | |
| DM3 | DM3 is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug conjugates. Synonyms: N2'-deacetyl-N2'-(4-mercapto-1-oxopentyl)- maytansine. Grade: ≥95%. CAS No. 796073-54-6. Molecular formula: C37H52ClN3O10S. Mole weight: 766.34. | |
| DM3 | DM3 (Maytansinoid DM3) is a maytansine analog bearing disulfide or thiol groups and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Maytansinoid DM3. CAS No. 796073-54-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-130080. | |
| DM3-SMe | DM3-SMe can be readily conjugate to the SH group of an antibody to form antibody-drug conjugate (ADC). Synonyms: N2'-deacetyl-N2'-[4-(R,S)-(methyldithio)-1-oxopentyl]maytansine. Grade: ≥98%. CAS No. 796073-70-6. Molecular formula: C38H54ClN3O10S2. Mole weight: 812.43. | |
| DM4 | DM4 is an anti-tubulin agent that inhibits cell division. DM4 can be used to prepare antibody-drug conjugates. DM4 binds to tubulin at the maytansine-binding site, disrupting microtubule assembly/disassembly dynamics and inhibiting mitosis. Synonyms: Maytansinoid DM 4; Maytansine, N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-; N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine; Ravtansine. Grade: ≥95%. CAS No. 796073-69-3. Molecular formula: C38H54ClN3O10S. Mole weight: 780.37. | |
| DM4-SMe | DM4-SMe can be readily conjugate to the SH group of an antibody to form antibody-drug conjugate (ADC). Synonyms: N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]maytansine. Grade: ≥98%. CAS No. 796073-68-2. Molecular formula: C39H56ClN3O10S2. Mole weight: 826.46. | |
| Maitansine | Maitansine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: maitansine;Maytansine;NSC 153858. CAS No. 35846-53-8. Molecular formula: C34H46ClN3O10. Mole weight: 692.201. Purity: 0.96. IUPACName: maytansine. Density: 1.32g/cm³. Product ID: ACM35846538. Alfa Chemistry ISO 9001:2015 Certified. | |
| Maytansinoid DM4 | DM4 is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug conjugates. Uses: Adcs cytotoxin. Synonyms: N2'-deacetyl-n2'-(4-Mercapto-4-Methyl-1-oxopentyl)-6-MethylMaytansine. Grade: ≥98.0% (HPLC). CAS No. 799840-96-3. Molecular formula: C39H56ClN3O10S. Mole weight: 780.37. | |
| Maytansinol | Maytansinol. Group: Biochemicals. Alternative Names: 3-O-De[2-[methyl(acetyl)amino]-1-oxopropyl]maytansine. Grades: Highly Purified. CAS No. 57103-68-1. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C28H37ClN2O8. US Biological Life Sciences. | Worldwide |
| Maytansinol | Maytansinol is an ansamacrolide isolated from P. verrucose. It was shown to inhibit microtubule assembly and induces microtubule disassembly in vitro. It exhibits antitumor activity. Synonyms: (3S)-3-O-De[2-(acetylmethylamino)-1-oxopropyl]-maytansine; Ansamitocin P-0; NSC239386; NSC-239386; Maytansine; Ansamitocin P 0; Antibiotic C 15003P; NSC 239386. Grade: 95%. CAS No. 57103-68-1. Molecular formula: C28H37ClN2O8. Mole weight: 565.06. | |
| Mertansine | Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC)[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DM1; Maytansinoid DM1. CAS No. 139504-50-0. Pack Sizes: 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19792. | |
| Mertansine | Mertansine, the cytotoxic component in antibody-drug conjugates, is attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker or SMCC (4-(3-mercapto-2,5-dioxo-1 pyrrolidinylmethyl)-cylohexanecarboxylic acid) linkerto create an antibody-drug conjugate. It derives from a maytansine. Synonyms: (14S,16S,33S,2R,4R,10E,12Z,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-(3-mercaptopropanoyl)-N-methyl-L-alaninate; N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine; DM 1; Maytansinoid DM 1; N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine; DM-1; DM1; DM1 Compound; DM1 [Maytansinoid]. Grade: ≥95%. CAS No. 139504-50-0. Molecular formula: C35H48ClN3O10S. Mole weight: 738.29. | |
| N-Me-L-Ala-maytansinol | N-Me-L-Ala-maytansinol is a hydrophobic, cell permeable payload used in the preparation of antibody-drug conjugate (ADC). Synonyms: AP3 Intermidate 1; Maytansinol 3-(S)-α-N-methylaminopropionate; Maytansine, N2'-deacetyl-; (1S,2R,3S,5S,6S,16Z,18Z,20R,21S)-11-Chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10(26),11,13,16,18-pentaen-6-yl N-methyl-L-alaninate; Maytansinol-Ala. Grade: 90%. CAS No. 77668-69-0. Molecular formula: C32H44ClN3O9. Mole weight: 650.17. | |
| Phomopsin A | It is an acidic 13-membered cyclic hexapeptide-like metabolite with three unusual amino acids. It is a potent mycotoxin produced by the fungus, phomopsis leptostromiformis. It is an important bioprobe for understanding cellular structural proteins. It selectively binds to the dimeric tubulin at the overlap of vinblastine and maytansine, inhibits the formation of the microtubule spindle to block cell division. Synonyms: 2-Oxa-5,8-diazabicyclo[10.3.1]hexadecane, cyclic peptide deriv.; (2E)-(βS)-3-chloro-β,5-dihydroxy-N-methyl-L-tyrosyl-3,4-didehydro-L-valyl-3-hydroxy-L-isoleucyl-3,4-didehydro-L-prolyl-(2E)-2,3-didehydroisoleucyl-2,3-didehydro-aspartic acid, cyclic (15→3)-ether; NSC 381839; PMSA; Phomopsin. Grade: >98% by HPLC. CAS No. 64925-80-0. Molecular formula: C36H45ClN6O12. Mole weight: 789.23. | |
| Phomopsin A | Phomopsin A is an acidic 13-membered cyclic hexapeptide-like metabolite with three unusual amino acids linked in an "ansa" macrocycle with a three amino acid "tail", terminating in a dicarboxylic acid. Phomopsin A is a potent mycotoxin produced by the fungus Phomopsis leptostromiformis and is the causative agent of lupinosis in livestock fed infected lupins. Phomopsin A is an important bioprobe for understanding cellular structural proteins. It acts by selectively binding to dimeric tubulin, inhibiting the formation of the microtubule spindle to block cell division. Phomopsin A binds to tubulin at a site overlapping that of vinblastine and maytansine. Uniquely, phomopsin A protects tubulin from decay. Group: Biochemicals. Alternative Names: 2-Oxa-5, 8-diazabicyclo[10. 3. 1]hexadecane, cyclic peptide deriv.; 3-Chloro-erythro- β,5-dihydroxy-N-methyl-L-tyrosyl-3,4-didehydro-L-valyl-3-hydroxy-L-isoleucyl-3,4-didehydro-L-prolyl-(E)-2,3-didehydroisoleucyl-(E)-2,3-didehydroaspartic acid cyclic (15?3)-ether; NSC 381839. Grades: Highly Purified. CAS No. 64925-80-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| S-methyl DM1 | S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds tubulin with a Kd of 0.93 μM and inhibits microtubule polymerization. S-methyl DM1 can effectively inhibit microtubule dynamic instability and has anticancer effects. Synonyms: N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine; [(1S,2R,3S,5S,6S,16Z,18Z,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[methyl(3-methylsulfanylpropanoyl)amino]propanoate. CAS No. 912569-84-7. Molecular formula: C36H50ClN3O10S. Mole weight: 752.31. | |
| sulfo-SPDB-DM4 | sulfo-SPDB-DM4 is a agent-linker conjugate for ADC by using the maytansinebased payload (DM4, an antitubulin agent) via the sulfo-SPDB linker. Uses: Scientific research. Group: Signaling pathways. CAS No. 1626359-59-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-101141. | |
| Trastuzumab emtansine | Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate ( ADC ) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine). Trastuzumab emtansine can be used for the research of advanced breast cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ado-Trastuzumab emtansine; PRO132365; T-DM 1. CAS No. 1018448-65-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9921. | |
| Trastuzumab emtansine (solution) | Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine). Trastuzumab emtansine can be used for the research of advanced breast cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ado-Trastuzumab emtansine (solution) ; PRO132365 (solution) ; T-DM 1 (solution). CAS No. 1018448-65-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9921A. | |
| Tusamitamab | Tusamitamab is an IgG1 monoclonal antibody that targets CEACAM5. Tusamitamab can be used to synthesize Tusamitamab ravtansine (SAR408701), which is a first-in-class humanized antibody-drug conjugate (ADC) that combines Tusamitamab and DM4 (a potent maytansine derivative) [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2349294-95-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99054. | |
| Ansamitocin P-3 | Ansamitocin P-3 (Antibiotic C 15003P3) is a microtubule inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic. Uses: Scientific research. Group: Natural products. Alternative Names: Antibiotic C 15003P3; Maytansinol isobutyrate. CAS No. 66584-72-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15739. | |
| DM21 | DM21 is a next-generation linker-payload that combines a maytansinoid microtubule-disrupting payload with a stable tripeptide linker. DM21 is conjugated with a humanized antibody against ADAM9 to obtain IMGC936[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2243689-80-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-139441. | |
| DM4-SPDP | DM4 with a reactive linker SPDP, which can react with antibody to make antibody drug conjugate. DM4 can bind to tubulin at or near the vinblastine-binding site. Synonyms: Maytansinoid DM4- succinimidyl 3-(2-pyridyldithio)propionate; DM4 SPDP. Grade: ≥98%. CAS No. 2245698-48-8. Molecular formula: C45H61ClN4O14S2. Mole weight: 981.57. | |
| Indatuximab ravtansine | Indatuximab ravtansine (BT-062) is an antibody-drug conjugate (ADC) ( Antibody-Drug Conjugates (ADCs) ) based on a murine/human chimeric form of B-B4 (specific for CD138), linked to the maytansinoid agent DM4 by disulphide bonds. Indatuximab ravtansine shows anti-tumor activities [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BT-062; nBT062-DM4. CAS No. 1238517-16-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-141607. | |
| Maytansinoid DM4 | Maytansinoid DM4 is a cytotoxic agent. It is used as a antibody-drug conjugate that has a potential to treat cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 799840-96-3. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C39H56ClN3O10S, Molecular Weight: 794.39. US Biological Life Sciences. | Worldwide |
| Mirvetuximab soravtansine (solution) | Mirvetuximab soravtansine (IMGN853) solution is an anti-folate receptor α ( FRα ) antibody drug-conjugate (ADC) consisting of the cytotoxic maytansinoid, DM4, covalently linked to the humanized monoclonal antibody M9346A. Mirvetuximab soravtansine selectively binds to folate receptor 1 (FOLR1). Mirvetuximab soravtansine has an anti-proliferative effect via growth arrest and augmented DNA damage [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IMGN853 (solution). CAS No. 1453084-37-1. Pack Sizes: 1 mg (10.246 mg/mL * 97.6 μL in 10mM Histidine pH=5.5); 5 mg (10.246 mg/mL * 488 μL in 10mM Histidine pH=5.5). Product ID: HY-132258A. | |
| N-Methyl-L-alanine hydrochloride | N-Methyl-L-alanine is a reactant used in the preparation of site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity. Synonyms: N-Me-L-Ala-OH HCl; N-Methyl-L-alanine; (2S)-2-(methylamino)propanoic acid. Grade: ≥ 98% (TLC). CAS No. 3913-67-5. Molecular formula: C4H9NO2·HCl. Mole weight: 139.62. | |
| SMCC-DM1 | SMCC-DM1 is a mertansine drug (DM1) with a reactive linker SMCC to make antibody drug conjugate. DM1 (mertansine), a thiol-containing maytansinoid, is a potent microtubule-disrupting agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 1228105-51-8. Pack Sizes: 1mg, 5mg. Molecular Formula: C51H66ClN5O16S, Molecular Weight: 1072.60999999999. US Biological Life Sciences. | Worldwide |
| S-Me-DM4 | S-Me-DM4 is a metabolite of DM4 S-methylated by intracellular enzyme. DM4 (HY-100503) is a microtubule-depolymerizing maytansinoid with strong cytotoxicity. DM4 can be used as an ADC Cytotoxin molecule[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 890654-03-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148818. | |
| sulfo-SPDB-DM4 | DM4 with a reactive linker sulfo-SPDB, which can react with antibody to make antibody drug conjugate. DM4 can bind to tubulin at or near the vinblastine-binding site. Synonyms: Maytansinoid DM4- succinimidyl 4-(N-maleimidomethyl)cyclohexane-3-sulfo-carboxylate. Grade: ≥98%. CAS No. 1626359-59-8. Molecular formula: C46H63ClN4O17S3. Mole weight: 1075.66. | |
| Trastuzumab emtansine | Trastuzumab emtansine is an antibody-drug conjugate (ADC) consisting of the recombinant anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab conjugated to the maytansinoid DM1 via a nonreducible thioether linkage (MCC) with potential antineoplastic activity. The trastuzumab moiety of this ADC binds to HER2 on tumor cell surface surfaces. Upon internalization, the DM1 moiety is released and binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics and inhibiting cell division and the proliferation of cancer cells that overexpress HER2. Linkage of antibody and drug through a nonreducible linker has been reported to contribute to the improved efficacy and reduced toxicity of this ADC compared to similar ADCs constructed with reducible linkers. Grade: 95%. CAS No. 1018448-65-1. Molecular formula: C6448H9948N1720O2012S44·(C47H62ClN4O13S)n. | |
| Tusamitamab ravtansine | Tusamitamab ravtansine (SAR-408701) is a targeted ADC against tumor cells expressing CEACAM5 , composed of a humanized anti-CEACAM5 monoclonal antibody covalently linked to the potent cytotoxic agent, maytansinoid DM4 (HY-12454), via a cleavable linker. Tusamitamab ravtansine has an average drug-to-antibody ratio (DAR) of 3.8 [1] [2] [3]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: SAR-408701; HuMAb2-3-SPDB-DM4. CAS No. 2254086-60-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99542. | |
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