Metalloproteas Suppliers USA
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Product | Description | |
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1-Methyl-1H-indazole-6-methanamine Quick inquiry Where to buy Suppliers range | 1-Methyl-Indazole-6-methanamine is a useful synthetic intermediate. It is an analog of 1H-Indazole-5-methanamine (I505500) which is used in the preparation of amide containing heterobicyclic metalloprotease inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 267413-31-0. Pack Sizes: 100mg, 1g. Molecular Formula: C9H11N3, Molecular Weight: 161.199999999999. US Biological Life Sciences. | Worldwide |
2-(14,15-Epoxyeicosatrienoyl) Glycerol Quick inquiry Where to buy Suppliers range | 2-(14,15-Epoxyeicosatrienoyl) Glycerol is a potent mitogen for renal epithelial cells, increasing DNA synthesis in LLCPKcl4 cells. It activates the metalloprotease ADAM17. Group: Biochemicals. Grades: Highly Purified. CAS No. 848667-56-1. Pack Sizes: 500ug, 1mg. Molecular Formula: C23H38O5, Molecular Weight: 394.54. US Biological Life Sciences. | Worldwide |
2,3-Dihydro-5-benzofuranmethanamine Hydrochloride Quick inquiry Where to buy Suppliers range | 2,3-Dihydro-5-benzofuranmethanamine is used in the preparation of azatricyclic metalloprotease inhibitors compounds. Group: Biochemicals. Alternative Names: 5-(Aminomethyl)-2,3-dihydrobenzofuran Hydrochloride. Grades: Highly Purified. CAS No. 635309-62-5. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
2-MPPA Quick inquiry Where to buy Suppliers range | 2-MPPA is a selective glutamate carboxypeptidase II (GCP II) inhibitor (IC50 = 90 nM), which is selective for GCP II over NMDA, kainate and AMPA glutamate receptors and MMP-1, -2, -3, -7, -9, ACE and NEP metalloproteases. 2-MPPA can be used in the treatment of neurological disorders associated with excessive activation of glutamatergic systems. Attenuates glutamate transmission resulting in the relief of neuropathic pain. This compound has neuroprotective properties. Synonyms: 2-(3-Mercaptopropyl)pentanedioic acid; 2-MPPA; 2 MPPA; 2MPPA. CAS No. 254737-29-6. Molecular formula: C8H14O4S. Mole weight: 206.26. | |
4-epi-Chlortetracycline Hydrochloride ((4R,4aS,5aS,6S,12aS)-7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide Monohydrate, 4-Epichlortetracycline Hydrochloride) Quick inquiry Where to buy Suppliers range | A Tetracycline derivative. It is a metalloprotease inhibitor, used in treating tissue destructive diseases and cancer. Group: Biochemicals. Alternative Names: (4R,4aS,5aS,6S,12aS)-7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide Monohydrate; 4-Epichlortetracycline Hydrochloride. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp Quick inquiry Where to buy Suppliers range | Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp is an intramolecularly quenched fluorescent substrate with the ortho-aminobenzoyl (Abz)/N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor/acceptor pair. It corresponds to the Swedish-mutated (JMV2236) β-amyloid precursor protein (βAPP) sequence, which is targeted by β-secretase BACE (β-site APP-cleaving activity). It is more selectively cleaved by BACE1 and BACE2 than by cathepsin D, a disintegrin and metalloprotease 10 (ADAM10), tumor necrosis α-converting enzyme (TACE), presenilin-1 (PS1), or presenilin-2 (PS2). Synonyms: JMV2236; L-α-Glutamine, N-(2-aminobenzoyl)-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-N-[2-[(2,4-dinitrophenyl)amino]ethyl]-; N-(2-Aminobenzoyl)-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-N-{2-[(2,4-dinitrophenyl)amino]ethyl}-L-α-glutamine. Grades: ≥95%. CAS No. 1007306-20-8. Molecular formula: C42H58N12O16. Mole weight: 986.99. | |
Aderbasib Quick inquiry Where to buy Suppliers range | Aderbasib is a sheddase inhibitor, is also an orally bioavailable inhibitor of the ADAM (A Disintegrin And Metalloprotease) family of multifunctional membrane-bound proteins with potential antineoplastic activity. Aderbasib represses the metalloproteinase "sheddase" activities of ADAM10 and ADAM17, which may result in the inhibition of tumor cell proliferation. Synonyms: INCB7839; INCB 7839; INCB-7839; INCB007839; INCB 007839; INCB-007839. CAS No. 791828-58-5. Molecular formula: C21H28N4O5. Mole weight: 416.48. | |
Aderbasib Quick inquiry Where to buy Suppliers range | Aderbasib is a azaspiro[2. 5]octanehydroxamide derivative as inhibitor of metalloproteases for the treatment of disorders such as cancer, arthritis, cardiovascular or skin disorders. Aderbasib, also known as INCB007839, is a sheddase inhibitor, is also an orally bioavailable inhibitor of the ADAM (A Disintegrin And Metalloprotease) family of multifunctional membrane-bound proteins with potential antineoplastic activity. Aderbasib represses the metalloproteinase "sheddase" activities of ADAM10 and ADAM17, which may result in the inhibition of tumor cell proliferation. The metalloproteinase domains of ADAMs cleave cell surface proteins at extracellular sites proximal to the cell membrane, releasing or "shedding" soluble protein etcodomains from the cell surface; the disintegrin domains of these multifunctional proteins interact with various components of the extracellular matrix (ECM). Group: Biochemicals. Alternative Names: (6S, 7S) -7-[ (Hydroxyamino) carbonyl]-6-[ (4-phenyl-1-piperazinyl) carbonyl]-5-azaspiro[2. 5]octane-5-carboxylic Acid Methyl Ester; INCB 007839. Grades: Highly Purified. CAS No. 791828-58-5. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??N?O?, Molecular Weight: 416.47. US Biological Life Sciences. | Worldwide |
Batimastat (BB-94) Quick inquiry Where to buy Suppliers range | Potent, broad spectrum matrix metalloprotease (MMP) inhibitor (IC?? values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts in vivo. Group: Biochemicals. Alternative Names: (2R, 3S) -N4-Hydroxy-N1-[ (1S) -2- (methylamino) -2-oxo-1- (phenylmethyl) ethyl]-2- (2-methylpropyl) -3-[ (2-thienylthio) methyl]butanediamide. Grades: Highly Purified. CAS No. 130370-60-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Batimastat sodium salt Quick inquiry Where to buy Suppliers range | Batimastat sodium salt (BB-94) is a potent, broad spectrum matrix metalloprotease (MMPs) inhibitor with IC50s of 3/4/20/6/4 nM for MMP-1/2/3/7/9 respectively. Synonyms: BB-94 sodium salt; BB 94 sodium salt; BB94 sodium salt. Grades: >98%. CAS No. 130464-84-5. Molecular formula: C23H30N3NaO4S2. Mole weight: 499.62. | |
CP 471474 Quick inquiry Where to buy Suppliers range | CP 471474 a broad spectrum Matrix Metalloprotease inhibitor with sub-nanomolar affinity for MMP-2 and 13 among MMPs (IC50: 1170, 0.7, 16, 13, 0.9 for MMP-1, MMP-2, MMP-3, MMP-9, and MMP-13 respectively). Synonyms: CP-471474; CP 471474; CP471474; UNII-96U47H947L; 2-[[4-(4-fluorophenoxy)phenyl]sulfonylamino]-N-hydroxy-2-methylpropanamide; CP 471474; CP-471474; 210755-45-6; CHEMBL323612. Grades: >97 %. CAS No. 210755-45-6. Molecular formula: C16H17FN2O5S. Mole weight: 368.38. | |
D-α-(3-Thienyl)glycine Quick inquiry Where to buy Suppliers range | D-α-(3-Thienyl)glycine is used to prepare amide containing heterobicyclic metalloprotease inhibitors. Synonyms: H-D-Thg(3)-OH; H-D-Gly(3-Thienyl)-OH. Grades: ≥ 98%. CAS No. 1194-86-1. Molecular formula: C6H7NO2S. Mole weight: 157.19. | |
GI 254023X Quick inquiry Where to buy Suppliers range | GI 254023X is a selective ADAM10 metalloprotease inhibitor with over 100-fold higher potency at ADAM10 than ADAM17. GI 254023X inhibits the proliferation of H929 cells, and calcium ionophore-induced betacellulin shedding in IMPE cells. It prevents E-cadherin cleavage in A549 cells, and suppresses ADAM10 mediated neuronal outgrowth of dorsal root ganglion neurons in vitro. Synonyms: GI254023X; GI 254023X; GI-254023X;GI4023; GI-4023; GI 4023. (2R)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-2-[(1S)-1-(N-hydroxyformamido)ethyl]-5-phenylpentanamide. Grades: ≥98% by HPLC. CAS No. 260264-93-5. Molecular formula: C21H33N3O4. Mole weight: 391.5. | |
L-Homocysteine Thiolactone Hydrochloride Quick inquiry Where to buy Suppliers range | L-Homocysteine Thiolactone Hydrochloride is used to prepare substituted homocysteine analogs as inhibitors of peptidylglycine α-amidating monooxygenase. It is also used to synthesize (mercaptoacyl)alanylprolines as metalloprotease inhibitors. Synonyms: (3S)-3-Aminodihydro-2(3H)-thiophenone Hydrochloride; (S)-3-Aminodihydro-2(3H)-thiophenone Hydrochloride; L-3-Aminodihydro-2(3H)-thiophenone Hydrochloride. Grades: > 95%. CAS No. 31828-68-9. Molecular formula: C4H8ClNOS. Mole weight: 153.63. | |
Luteolin 7-O-Rutinoside Quick inquiry Where to buy Suppliers range | Luteolin 7-O-Rutinoside acts as a metalloprotease inhibitor and is extracted as a component of flowering plants. Luteolin 7-O-Rutinoside is one such flavonoid additionally providing antigenotoxic activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 20633-84-5. Pack Sizes: 1mg, 5mg. Molecular Formula: C27H30O15, Molecular Weight: 594.52. US Biological Life Sciences. | Worldwide |
Marimastat ( (2S, 3R) -N4-[ (1S) -2, 2-Dimethyl-1-[ (-[ (methylamino) carbonyl]propyl]-N1, 2-dihydroxy-3- (2-methylpropyl) butanediamide, BB-2516, TA-2516) Quick inquiry Where to buy Suppliers range | A broad spectrum matrix metalloprotease (MMP) inhibitor with IC50 values of 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively. It covalently binds to the zinc(II) ion in the active site of MMPs, thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide Quick inquiry Where to buy Suppliers range | TAPI 2 is an ADAM-17 (TACE) and matrix metalloprotease (MMP) inhibitor (Ki = 120 nM at ADAM-17). TAPI 2 sensitizes cancer stem cells to the lethal effects of 5-FU in vitro, and inhibits shedding of TNF-α from cell membranes. Synonyms: TAPI 2; TAPI2; TAPI-2; N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide; Immunex compound 1. Grades: ≥95% by HPLC. CAS No. 689284-12-6. Molecular formula: C19H37N5O5. Mole weight: 415.54. | |
SB-3CT Quick inquiry Where to buy Suppliers range | SB-3CT is a potent matrix metalloproteinase MMP-2 and MMP-9 inhibitor. SB-3CT is a 2-[(arylsulfonyl)methyl]thiirane that achieves potent inhibition, by a thiirane-opening mechanism, of the MMP2 and MMP9 zinc metalloproteases. SB-3CT attenuates behavioral impairments and hippocampal loss after traumatic brain injury in rat. Matrix metalloproteinases (MMPs) are involved in a number of activities including angiogenesis and embryogenesis. Besides, gelatinases A (MMP-2) and B (MMP-9), are thought to facilitate tumor metastasis. Synonyms: MMP-2/MMP-9 Inhibitor IV; 2- ( (4-phenoxyphenylsulfonyl) methyl) thiirane; SB-3CT; SB3CT; SB3-CT; IN1250; IN 1250; IN-1250. Grades: 98%. CAS No. 292605-14-2. Molecular formula: C15H14O3S2. Mole weight: 306.394. | |
TAPI 0 Quick inquiry Where to buy Suppliers range | TAPI 0 is an ADAM-17 (TACE) and matrix metalloprotease (MMP) inhibitor. TAPI 0 can inhibit spontaneous and PMA-induced TNF α release and processing. Synonyms: N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-L-alaninamide; KD-IX 73-4; TAPI; TNF-a Protease Inhibitor 0; TAPI 0; TAPI0; TAPI-0. Grades: ≥95% by HPLC. CAS No. 163958-73-4. Molecular formula: C24H32N4O5. Mole weight: 456.54. | |
TAPI-2 Quick inquiry Where to buy Suppliers range | A broad spectrum inhibitor of MMPs and ADAMs (proteins containing A Disintegrin and A Metalloprotease domain). This inhibitor has been used in tissue culture (typical concentration 5-100uM). Group: Biochemicals. Alternative Names: N- (R) - (2- (Hydroxyaminocarbonyl) methyl) -4-methylpentanoyl-L-naphthylalanyl-L-alanine Amide, TNF protease inhibitor-0, C1. Grades: Highly Purified. CAS No. 187034-31-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Ubenimex Quick inquiry Where to buy Suppliers range | Ubenimex (INN), also known more commonly as bestatin, is a competitive, reversible protease inhibitor. It is an inhibitor of arginyl aminopeptidase (aminopeptidase B), leukotriene A4 hydrolase (a zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities), alanyl aminopeptidase (aminopeptidase M/N), leucyl/cystinyl aminopeptidase (oxytocinase/vasopressinase), and membrane dipeptidase (leukotriene D4 hydrolase). It is being studied for use in the treatment of acute myelocytic leukemia. It is derived from Streptomyces olivoreticuli. Ubenimex has been found to inhibit the enzymatic degradation of oxytocin, vasopressin, enkephalins, and various other peptides and compounds. Group: Main Products. Alternative Names: 3-(r)-amino-2-(s)-hydroxy-4-phenylbutanoyl-(s)-leucine;n-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-,(s-(r*,s*))-l-leucin;nk421;UBENIMEX;N-[(2S,3R)-3-AMINO-2-HYDROXY-1-OXO-4-PHENYLBUTYL]-L-LEUCINE;N-((2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL)-L-LEUCINE;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL]-L-LEUCINE;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-LEU. Grades: 99%. CAS No. 58970-76-6. Product ID: ACM58970766. Molecular formula: C16H24N2O4. Mole weight: 308.37. IUPAC Name: (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoicacid. Appearance: White crystalline powder. EC Number: 261-529-2. Boiling Point: 604.7ºC at 760 mmHg. Melting Point: 245ºC. Flash Point: 319.5ºC. Density: 1.197 g/cm³. | |
UK-356618 Quick inquiry Where to buy Suppliers range | Potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) (IC50 = 5.9 nM). Displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively). Group: Biochemicals. Alternative Names: (2R) -N1- [ (1S) -2, 2-Dimethyl-1- [ [ [ (1R) -1-phenylethyl] amino] carbonyl] propyl] -N4-hydroxy-2- [3- (2-methyl [1, 1'-biphenyl] -4-yl) propyl] butanediamide; UK 356618;PF-03890101. Grades: Highly Purified. CAS No. 230961-08-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
WS75624 A Quick inquiry Where to buy Suppliers range | WS75624 A is an endothelin converting enzyme (ECE) inhibitor isolated from the fermentation broth of Saccharothrix sp. No. 75624. It also showed other metalloprotease (collagenase and neutral endopeptidase) inhibitory activity with IC50 value of 1 mM/ml. Synonyms: WS-75624 A; WS 75624 A; WS-75624A. Molecular formula: C18H24N2O5S. Mole weight: 380.5. | |
WS75624 B Quick inquiry Where to buy Suppliers range | WS75624 B is an endothelin converting enzyme (ECE) inhibitor isolated from the fermentation broth of Saccharothrix sp. No. 75624. It also showed other metalloprotease (collagenase and neutral endopeptidase) inhibitory activity with IC50 value of 1 mM/ml. Synonyms: WS-75624 B; WS 75624 B; WS-75624B. Molecular formula: C18H24N2O5S. Mole weight: 380.5. |