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Metaphit. Group: Biochemicals. Grades: Purified. CAS No. 96316-00-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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Metaphit methanesulfonate salt
Metaphit methanesulfonate salt. Group: Biochemicals. Alternative Names: 1- (1-[3-Isothiocyanato]phenyl) cyclohexylpiperidine, methanesulfonate salt. Grades: Highly Purified. CAS No. 99287-12-4. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C19H28N2O3S2. US Biological Life Sciences.
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Metaphit Methanesulfonate Salt (1- (1-[3-Isothiocyanato]phenyl) cyclohexylpiperidine, Methanesulfonate Salt)
An irreversible, non-competitive antagonist at the PCP site on the NMDA receptor, and an irreversible, competitive antagonist at sigma receptors. Group: Biochemicals. Alternative Names: 1- (1-[3-Isothiocyanato]phenyl) cyclohexylpiperidine, Methanesulfonate Salt. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
Metapramine, a low-affinity NMDA receptor antagonist, is a tricyclic antidepressant (TCA) used to treat depression. In addition to its efficacy against affective disorders, it has analgesic properties and may be useful in treating pain. It is a norepinephrine reuptake inhibitor without affecting serotonin or dopamine reuptake. Uses: Antidepressive agents, tricyclic. Synonyms: 10,11-Dihydro-N,5-dimethyl-5H-Dibenz[b,f]azepin-10-amine; 5-Methyl-10-methylamino-10,11-dihydrodibenzo[b,f]azepine; Metapramine; RP 19560; 10,11-Dihydro-5-methyl-10-5H-Dibenz[b,f]azepine. Grades: 95%. CAS No. 21730-16-5. Molecular formula: C16H18N2. Mole weight: 238.33.
Metapramine
Metapramine is a tricyclic antidepressant derived from dibenzoazepine. Metapramine acts as a norepinephrine reuptake inhibitor without affecting the reuptake of serotonin or dopamine. Group: Biochemicals. Alternative Names: 10,11-Dihydro-N,5-dimethyl-5H-Dibenz[b,f]azepin-10-amine; 5-Methyl-10-methylamino-10, 11-dihydrodibenzo[b, f]azepine; Metapramine; RP 19560; 10,11-Dihydro-5-methyl-10-5H-Dibenz[b,f]azepine. Grades: Highly Purified. CAS No. 21730-16-5. Pack Sizes: 10mg. US Biological Life Sciences.
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Metaproterenol hemisulfate salt
Metaproterenol hemisulfate salt. Group: Biochemicals. Grades: Highly Purified. CAS No. 5874-97-5. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C11H17NO3·½H2SO4. US Biological Life Sciences.
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Metaproterenol hemisulfate salt
Metaproterenol hemisulfate salt is the hemisulfate salt form of Metaproterenol, which is a moderately selective beta-adrenergic agonist. It is used in the treatment of asthma and bronchospasms. It was developed by Boehringer-Ingelheim and has been withdraw from the market. Uses: Metaproterenol hemisulfate salt is used in the treatment of asthma and bronchospasms. Synonyms: Orciprenaline sulfate;Th-152; Th 152; Th152; 3-Hydroxy-5-(1-hydroxy-2-(isopropylamino)ethyl)phenyl hydrogen sulfate;5-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,3-benzenediol Sulfate;3,5-Dihydroxy-α-[(isopropylamino)methyl]benzyl Alcohol Sulfate;1-(3,5-Dihydroxyph. Grades: 95%. CAS No. 5874-97-5. Molecular formula: C11H17NO3 1/2H2O4S. Mole weight: 260.30.
Metaproterenol sulfate
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
100g Pack Size. Group: Building Blocks, Inorganic Chemicals, Salts. Formula: AlO9P3. CAS No. 13776-88-0. Prepack ID 90026925-100g. Molecular Weight 263.9. See USA prepack pricing.
Aluminum metaphosphate
Aluminum metaphosphate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Aluminiummetaphosphate;metaphosphoricacid(hpo3),aluminumsalt;Metaphosphoricacid,aluminumsalt;ALUMINUM METAPHOSPHATE;ALUMINUM PHOSPHATE, META;Trimetaphosphoric acid aluminum salt;(Triphosphoric acid α,β,γ-aluminum)α,γ-anhydride salt. Product Category: Metal & Ceramic Materials. CAS No. 13776-88-0. Molecular formula: AlO9P3. Mole weight: 263.9. Purity: PURIFIED. Product ID: ACM13776880. Alfa Chemistry ISO 9001:2015 Certified. Categories: Metaphosphoric acid (HPO3).
Aluminum Metaphosphate
Aluminum Metaphosphate. Grades: 99.99% Extremely High (>=99%). CAS No. 32823-06-6. Pack Sizes: Gram Quantities: 25 gm, 100 gm. Order Number: 1021.
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Aluminum Metaphosphate
Aluminum Metaphosphate. Grades: 99.9% Extremely High (>=99%). CAS No. 32823-06-6. Pack Sizes: Gram Quantities: 250 gm , 1 kg. Order Number: 1020.
Lithium Metaphosphate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: lithium polymetaphosphate. Appearance: White solid. CAS No. 13762-75-9. Molecular formula: LiO3P. Mole weight: 85.9g/mol. Purity: 0.99. Canonical SMILES: [Li+].[O-]P(=O)=O. ECNumber: 237-361-0. Product ID: ACM13762759. Alfa Chemistry ISO 9001:2015 Certified. Categories: METAPHOSPHORIC ACID.
Potassium Metaphosphate
POTASSIUM METAPHOSPHATE, 98%, (Synonym: Monopotassium metaphosphate), Formula: KPO3. CAS No. 7790-53-6. Noah Chemicals San Antonio, Texas. ISO 9001:2015 Certified. Request a Quote Today!
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Sodium metaperiodate
100g Pack Size. Group: Analytical Reagents, Biochemicals, Building Blocks, Salts. Formula: INaO4. CAS No. 7790-28-5. Prepack ID 61500407-100g. Molecular Weight 213.89. See USA prepack pricing.
Sodium metaperiodate
25g Pack Size. Group: Analytical Reagents, Biochemicals, Building Blocks, Salts. Formula: INaO4. CAS No. 7790-28-5. Prepack ID 61500407-25g. Molecular Weight 213.89. See USA prepack pricing.
Sodium Metaperiodate
SODIUM METAPERIODATE, 99.9% pure, ACS Reagent, -100 mesh, (Synonym: Sodium Periodate), Formula: NaIO4. CAS No. 7790-28-5. Noah Chemicals San Antonio, Texas. ISO 9001:2015 Certified. Request a Quote Today!
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Sodium Metaperiodate
Sodium Metaperiodate. Grades: 99.% Extremely High (>=99%). CAS No. 7790-28-5. Pack Sizes: Kilogram Quanitites: 1 kg, 5 kg. Order Number: 3281.
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Sodium metaphosphate
1kg Pack Size. Group: Analytical Reagents, Inorganic Chemicals, Salts. Formula: NaO3P. CAS No. 10361-03-2. Prepack ID 90027092-1kg. Molecular Weight 101.96. See USA prepack pricing.
SODIUM METAPHOSPHATE
SODIUM METAPHOSPHATE. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SODIUM PHOSPHATE, PH 6.8;SODIUM M-PHOSPHATE;ISMP;INSOLUBLE SODIUM METAPHOSPHATE;GRAHAM'S SALT;Sodium acid metaphosphate. Product Category: Heterocyclic Organic Compound. CAS No. 35270-09-8. Molecular formula: NaO3P. Mole weight: 101.96. Purity: 0.96. IUPACName: SODIUM METAPHOSPHATE. Product ID: ACM35270098. Alfa Chemistry ISO 9001:2015 Certified.
TNP-470 (AGM-1470, O-(Chloroacetyl-carbamoyl)fumagillol, AGM1470, MetAP-2 Inhibitor II, MetAP2 Inhibitor II, Methionine Aminopeptidase 2 Inhibitor II, TNP470)
A cell-permeable Fumagillin analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity (IC50 = 1nM against human MetAP2), without affecting the inhibitory activity of MetAP2 against HRI- (heme-regulated inhibitor kinase) catalyzed eIF-2alpha phosphorylation. A potent endothelial cytostasis inducer (IC50 = 25 pM and 37 pM, respectively, against HUVEC and bovine BAEC) in vitro and an effective anti-angiogenesis agent in vivo (2-100mg/kg in mice and rats; s.c.). Group: Biochemicals. Grades: Highly Purified. CAS No. 129298-91-5. Pack Sizes: 10mg. US Biological Life Sciences.
10,10'-Oxybis(5-methyl-10,11-dihydro-5H-dibenzo[b,f]azepine) is an impurity in the synthesis of Metapramine (M225830), a norepinephrine reuptake inhibitor without affecting the reuptake of serotonin or dopamine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C30H28N2O. US Biological Life Sciences.
10,10'-Oxybis(5-methyl-10,11-dihydro-5H-dibenzo[b,f]azepine) is an impurity of Metapramine, which is a tricyclic antidepressant (TCA) used to treat depression. Synonyms: 5H-Dibenz[b,f]azepine, 10,10'-oxybis[10,11-dihydro-5-methyl-. Molecular formula: C30H28N2O. Mole weight: 432.56.
10,11-Dihydro-5-methyl-5H-dibenz[b,f]azepin-10-amine is an metabolites of Metapramine (M225830), found in plasma in depressed inpatients. Group: Biochemicals. Grades: Highly Purified. CAS No. 21808-11-7. Pack Sizes: 25mg, 100mg. Molecular Formula: C15H16N2. US Biological Life Sciences.
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10,11-Dihydro-5-methyl-5H-dibenz[b,f]azepin-10-ol
10,11-Dihydro-5-methyl-5H-dibenz[b,f]azepin-10-ol is an metabolites of Metapramine (M225830), found in plasma in depressed inpatients. Group: Biochemicals. Grades: Highly Purified. CAS No. 28291-62-5. Pack Sizes: 25mg, 100mg. Molecular Formula: C15H15NO. US Biological Life Sciences.
10,11-Dihydro-5-methyl-5H-dibenz[b,f]azepine-10-carbamic Acid Ethyl Ester is an intermediate in the synthesis of Metapramine (M225830), a norepinephrine reuptake inhibitor without affecting the reuptake of serotonin or dopamine. Group: Biochemicals. Grades: Highly Purified. CAS No. 30761-57-0. Pack Sizes: 100mg, 250mg. Molecular Formula: C18H20N2O2. US Biological Life Sciences.
10-Azido-5-methyl-10,11-dihydro-5H-dibenzo[b,f]azepine is an intermediate in the synthesis of Metapramine (M225830), a tricyclic antidepressant derived from dibenzoazepine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg, 100mg. Molecular Formula: C15H14N4. US Biological Life Sciences.
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2,4-Diaminobenzenesulfonic acid sodium salt
2,4-Diaminobenzenesulfonic acid sodium salt. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2,4-DIAMINO-BENZENESULFONIC ACID, MONOSODIUM SALT;2,4-DIAMINOBENZENESULPHONATE SODIUM;1,3-PHENYLENEDIAMINE-4-SULPHONIC ACID SODIUM SALT;MPDSA sodium salt;metaPhenylenediamine-4-Sulfonic Acid Sodium Salt;Metaphenylenediamine-4-sulfonicacid,SS;MPDSA,FA;2,4. Product Category: Heterocyclic Organic Compound. CAS No. 3177-22-8. Molecular formula: C6H7N2NaO3S. Mole weight: 210.18. Density: 1.611g/cm³. Product ID: ACM3177228. Alfa Chemistry ISO 9001:2015 Certified. Categories: Sodium 2,4-diaminobenzenesulfonate.
2-(Ethylthio)-1H-benzimidazole
2-(Ethylthio)-1H-benzimidazole is the active substance or the active ingredient in the synthesis of the drug Metaprot. Performs a transplacental function: daily administration of bemithyl (20 mg/kg) from 6 th to 16 th day of pregnancy in female rats led to the decrease in fetal death after the implantation and increased fetal body weight. Group: Biochemicals. Grades: Highly Purified. CAS No. 14610-11-8. Pack Sizes: 250mg, 500mg. Molecular Formula: C9H10N2S. US Biological Life Sciences.
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4-Aminoantipyrine
analytical standard. Group: Method and regulation specificpharma & vet compounds & metabolitespharma & vet compounds & metabolitesbuilding blocks. Alternative Names: (2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)amine, 4-AAP, 1,2-Dihydro-1,5-dimethyl-2-phenyl-4-amino-3H-pyrazol-3-one, Antipyrine, 4-amino- (8CI), 4-Amino-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one, Aminoantipyrine, 4-Amino-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one, NSC 60242, 4-Amino-1,5-dimethyl-3-oxo-2-phenylpyrazoline,Metamizole Sodium Monohydrate Imp. B (EP), Metamizole Imp. B (EP), 4-Amino-2,3-dimethyl-1-phenyl-5-pyrazolone, 4-Amino-2,3-dimethyl-1-phenylpyrazolin-5-one, 4-Amino-1,5-dimethyl-2-phenyl-3-pyrazolone, 1-Phenyl-2,3-dimethyl-4-amino-5-pyrazolone, Metapirazone, Ampyrone, 4-Aminophenazone, Aminoazophene, Solvapyrin A, 4-Amino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one, 4-Amino-1-phenyl-2,3-dimethyl-5-pyrazolone, 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, 4-Amino-1,5-dimethyl-2-phenyl-4-pyrazolin-3-one, 4-Aminoantipyrine, 4-Amino-1,5-dimethyl-2-phenylpyrazolin-3-one, 4-Amino-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one, 4-Amino-1,5-dimethyl-2-phenyl-1H-pyrazol-3-one, 4-Amino-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one.
4-Aminophenazone
A metabolite of aminopyrine, having both analgesic and anti-inflammatory properties. Group: Biochemicals. Alternative Names: 4-Amino-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one; 4-Aminoantipyrine; (2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)amine; 1,2-Dihydro-1,5-dimethyl-2-phenyl-4-amino-3H-pyrazol-3-one; minoazophene; Ampyrone; Metapirazone; NSC 60242; Solvapyrin A. Grades: Highly Purified. CAS No. 83-07-8. Pack Sizes: 5g. US Biological Life Sciences.
5,11-Dihydro-5-methyl-10H-dibenz[b,f]azepin-10-one is an intermediate in the synthesis of Metapramine (M225830), a norepinephrine reuptake inhibitor without affecting the reuptake of serotonin or dopamine. Group: Biochemicals. Grades: Highly Purified. CAS No. 4904-83-0. Pack Sizes: 25mg, 100mg. Molecular Formula: C15H13NO. US Biological Life Sciences.
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A 357300 hydrochloride
A 357300 hydrochloride is a potent and reversible inhibitor of methionine aminopeptidase-2 (MetAP-2). In murine models, it significantly inhibits CHP-134-derived neuroblastoma s.c. xenograft growth rate with a treatment-to-control (T/C) ratio at day 24 of 0.19 (P < 0.001) without toxicity. Uses: Novel treatment of neuroblastoma. Synonyms: A-357300; A 357300; A357300; N'-(3-amino-2-hydroxy-5-(isopropylthio)pentanoyl)-3-chlorobenzohydrazide hydrochloride. Grades: 99%. CAS No. 369358-07-6. Molecular formula: C15H22ClN3O3S.HCl. Mole weight: 396.33.
Adrenorphin
Adrenorphin is an opioid octapeptide that acts as an agonist of μ-opioid receptor. Synonyms: L-Valinamide, L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-; L-Tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-L-valinamide; Adrenorphin (human); Adrenorphin (ox); BAM 8; Metaphinamide; Metorphamide; Metorphamide (ox); Metorphinamide; H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2. Grades: >95%. CAS No. 88377-68-8. Molecular formula: C44H69N15O9S. Mole weight: 984.18.
Adrenorphin TFA
Adrenorphin TFA is an opioid octapeptide that acts as an agonist of μ-opioid receptor with a Ki of 12 nM. Synonyms: Adrenorphin (human), trifluoroacetate (salt); L-Tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-L-valinamide trifluoroacetate; Adrenorphin (ox) trifluoroacetat; BAM 8 trifluoroacetate; Metaphinamide trifluoroacetate; Metorphamide trifluoroacetate; Metorphamide (ox) trifluoroacetate; Metorphinamide trifluoroacetate; H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2.TFA; Adrenorphin 3TFA. Grades: ≥95%. Molecular formula: C46H70F3N15O11S. Mole weight: 1098.22.
Apcin
Apcin is an inhibitor of the E3 ligase activity of the mitotic anaphase-promoting complex/cyclosome (APC/C), which is a large multimeric complex. It functions as a ubiquitin ligase, initiating the metaphase-anaphase transition and regulating ordered transitions through the cell cycle by controlling the ubiquitin-mediated proteolysis of cell cycle proteins. It competitively binds to the D-box binding site of Cdc20 and prevents substrate recognition and ubiquitylation required for continuation of mitosis. It synergistically increases apoptosis in multiple myeloma cells in combination with proTAME (prodrug of TAME). It also prolongs mitotic duration in RPE1 cells in combination with proTAME in vitro. It blocks mitotic exit and being synergistically amplified by co-addition of Ts-Arg-OMe. Synonyms: 3-(2-Methyl-5-nitro-imidazol-1-yl)-N-(2,2,2-trichloro-1-phenylamino-ethyl)-propionamide; 2-(2-Methyl-5-nitroimidazol-1-yl)ethyl N-[2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl]carbamate; [2,2,2-trichloro-1-(2-pyrimidinylamino)ethyl]-carbamic acid, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester. Grades: ≥98% by HPLC. CAS No. 300815-04-7. Molecular formula: C13H14Cl3N7O4. Mole weight: 438.65.
Beloranib
Beloranib is a fumagillin-class methionine aminopetidase-2 (MetAP2) inhibitor. Beloranib decreases food intake, body weight, fat mass, and the size of adipocytes [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ZGN-440; CKD-732 free base. CAS No. 251111-30-5. Pack Sizes: 1 mg. Product ID: HY-14811.
Bengamide B
Bengamide B is a potent inhibitor of methionine amino transferase (MetAPs 1 and -2), and it also acts as a NF-kB blocker. Bengamide B exhibits inhibitory activity for proliferation of HeLa and HCT116 cells. Uses: Antitumor and anti-inflammatory agent. Synonyms: (6E)-6,7,8,9-Tetradeoxy-N-[(3S,6S)-hexahydro-1-methyl-2-oxo-6-[(1-oxotetradecyl)oxy]-1H-azepin-3-yl]-8-methyl-2-O-methyl-D-gulo-Non-6-enonamide. Grades: ≥97% by HPLC. CAS No. 104947-69-5. Molecular formula: C32H58N2O8. Mole weight: 598.81.
Boc-(S)-2-amino-3-hydroxy-3-methylbutanoic acid
Boc-(S)-2-amino-3-hydroxy-3-methylbutanoic acid is used as a reagent in the synthesis of metabolites of PPI-2458, which is a selective, irreversible inhibitor of methionine aminopeptidase-2 (MetAP2). N-Boc-3-hydroxy-L-valine is also used in the preparation of Boceprevir, an NS3 serine protease inhibitor of hepatitis C virus for the treatment of HCV infection. Synonyms: Boc-L-Ser(3,3-dimethyl)-OH; (S)-Boc-β,β-dimethyl-serine; N-[(1,1-Dimethylethoxy)carbonyl]-3-methyl-L-threonine; N-[(1,1-Dimethylethoxy)carbonyl]-3-hydroxy-L-valine; (S)-2-(tert-Butoxycarbonylamino)-3-hydroxy-3-methylbutanoic Acid; n-boc-(s)-2-amino-3-hydroxy-3-methylbutanoic acid; (S)-2-N-Boc-amino-3-hydroxy-3-methylbutyric acid; (S)-N-Boc-2-Amino-3-hydroxy-3-methylbutanoic acid; L-Valine, N-[(1,1-dimethylethoxy)carbonyl]-3-hydroxy-; L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-; N-(tert-butoxycarbonyl)-3-hydroxy-L-valine; (2S)-2-(N-tert-Butoxycarbonyl)amino-3-hydroxy-3-methylbutanoic acid; N-boc-3-hydroxy-L-valine. Grades: ≥ 98% (Assay). CAS No. 102507-13-1. Molecular formula: C10H19NO5. Mole weight: 233.26.
catechol 2,3-dioxygenase
Requires FeII. The enzyme initiates the meta-cleavage pathway of catechol degradation. Group: Enzymes. Synonyms: 2,3-pyrocatechase; catechol 2,3-oxygenase; catechol oxygenase; metapyrocatechase; pyrocatechol 2,3-dioxygenase; xylE (gene name); catechol:oxygen 2,3-oxidoreductase (decyclizing). Enzyme Commission Number: EC 1.13.11.2. CAS No. 9029-46-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0539; catechol 2,3-dioxygenase; EC 1.13.11.2; 9029-46-3; 2,3-pyrocatechase; catechol 2,3-oxygenase; catechol oxygenase; metapyrocatechase; pyrocatechol 2,3-dioxygenase; xylE (gene name); catechol:oxygen 2,3-oxidoreductase (decyclizing). Cat No: EXWM-0539.
cis-Fumagillin methyl ester
Cis-Fumagillin methyl ester is originally isolated from Penicillum sp. F2757. It inhibits the MetAP2 and MetAPI with IC50 of 6.3nmol/L and <200nmol/L, respectively. Molecular formula: C27H36O7. Mole weight: 472.57.
Colcemid
Anti-cancer compound. Cell synchronization agent. Used as a drug in chemotherapy by synchronizing tumor cells at metaphase, the radiosensitive stage of the cell cycle. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation). Inhibits mitosis during cell division at metaphase by inhibiting spindle formation. Low concentrations affect microtubule dynamics and cell migration, while high concentrations promote microtubule detachment from microtubule organizing center. Apoptosis inducer and thrombopoietic agent.Source:Semi-synthetic from colchicine: Group: Biochemicals. Grades: Highly Purified. CAS No. 477-30-5. Pack Sizes: 1mg, 5mg. Molecular Formula: C21H25NO5, Method for Determining. US Biological Life Sciences.
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Dipyrone
Dipyrone is a non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Dipyrone blocks PGE2-induced hyperalgesia in several models. Group: Biochemicals. Alternative Names: 1- [ (2, 3-Dihydro-1, 5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl) methylamino] methanesulfonic Acid Sodium Salt; (Antipyrinyl methyl amino) methanesulfonic Acid Sodium Salt; ARPF; Algocalmin; Algopyrin; Anador; Analgin; Analgine; Andolor; Conmel; Diprofarn; Gifaril; Lisador; Metamizol; Metamizole; Metamizole Sodium; Metamizole Sodium Salt; Metapyrin; Methamizole Sodium; Methampyrone; Methylmelubrin; Metilon; Narone; Sulpin; Sulpyrin; Sulpyrine. Grades: Highly Purified. CAS No. 68-89-3. Pack Sizes: 1g. US Biological Life Sciences.
The product contains 4 or 5 phosphate residues. Group: Enzymes. Synonyms: polyphosphate depolymerase; metaphosphatase; polyphosphatase; polymetaphosphatase. Enzyme Commission Number: EC 3.6.1.10. CAS No. 9024-86-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4594; endopolyphosphatase; EC 3.6.1.10; 9024-86-6; polyphosphate depolymerase; metaphosphatase; polyphosphatase; polymetaphosphatase. Cat No: EXWM-4594.
Exopolyphosphatase (PPX) is a phosphatase enzyme which catalyzes the hydrolysis of inorganic polyphosphate, a linear molecule composed of up to 1000 or more monomers linked by phospho-anhydride bonds. PPX is a processive exophosphatase, which means that it begins at the ends of the polyphosphate chain and cleaves the phospho-anhydride bonds to release orthophosphate as it moves along the polyphosphate molecule. PPX has several characteristics which distinguish it from other known polyphosphatases, namely that it does not act on ATP, has a strong preference for long chain polyphosphate, and has a very low affinity for polyphosphate molecules with less than 15 phosphate monomers. Group: Enzymes. Synonyms: metaphosphatase; acid phosphoanhydride phosphohydrolase; Gra-Pase. Enzyme Commission Number: EC 3.6.1.11. CAS No. 9024-85-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4595; exopolyphosphatase; EC 3.6.1.11; 9024-85-5; metaphosphatase; acid phosphoanhydride phosphohydrolase; Gra-Pase. Cat No: EXWM-4595.
GSI-953
Begacestat (GSI-953) is a selective β-secretase inhibitor that selectively inhibits cleavage of APP over Notch. GSI-953 is used for treating diseases such as cancer in relation to prevention of intestinal secretory metaplasia. Group: Biochemicals. Alternative Names: 5-Chloro-N-[ (1S) -3, 3, 3-trifluoro-1- (hydroxymethyl) -2- (trifluoromethyl) propyl]-2-thiophenesulfonamide; Begacestat; GSI 953. Grades: Highly Purified. CAS No. 769169-27-9. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Indibulin
Indibulin, also called D 24851, estabilizes tubulin polymerization (IC50 = 0.3 μM) and induces tumor cell cycle arrest and apoptosis. In vitro: blocking cell cycle progression at metaphase; In vivo: induce complete tumor remission in the Yoshida AH13 rat sarcoma model. Synonyms: 2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide; D 24851; D-24851; indibulin; N-(pyridin-4-yl)-(1-(4-chlorobenzyl)indol-3-yl)glycoxylamide; N-(pyridin-4-yl)-(1-(4-chlorobenzyl)indol-3-yl)glyoxylamide. CAS No. 204205-90-3. Molecular formula: C22H16ClN3O2. Mole weight: 389.83.
L-Lysine (Standard)
L-Lysine (Standard) is the analytical standard of L-Lysine. This product is intended for research and analytical applications. L-lysine is an essential amino acid for humans with orally activity. L-lysine can inhibit the occurrence of HSV infections and is used in herpes research. L-lysine increases calcium absorption, reduces diabetes-related diseases, improves gut health, and alleviates pancreatic inflammation. L-lysine can be used in research on metabolism, infection, and inflammation [1] [2] [3] [4]. IC 50 & Target:L-lysine (150 mg/kg) promotes, but not initiates, bladder cancer. The administration of L-lysine to rats submitted to colovesical cystoplasty accelerates the development of transitional metaplasia of the intestinal epithelium [1]. L-lysine (10 mg/kg) treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhance antioxidant activity [2]. In Vivo: L-lysine (10 mg/kg, p.o., pre-treated or post-treated, administration duration 15 days) treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhance antioxidant activity in acute pancreatitis mice model [1]. L-lysine (5 or 10 mg/kg, p.o., 45 days) ameliorates sepsis-induced acute lung injury in a lipopolysaccharide (HY-D1056)-induced mouse model [3]. Uses: Scientific research. Group: Natural products. CAS No
LY-195448
LY-195448 is a phenethanolamine. It blocks cells at metaphase. It has shown anti-tumour activity. Uses: Ly-195448 has shown anti-tumour activity. Synonyms: LY 195448; LY195448; LY-195448; UNII-BR0DFE3GF6. (R)-4-(3-((2-Hydroxy-2-phenethyl)amino)-3-methylbutyl)benzamide monohydrochloride;4-[3-[[(2R)-2-hydroxy-2-phenylethyl]amino]-3-methylbutyl]benzamide hydrochloride. Grades: >98%. CAS No. 111112-18-6. Molecular formula: C20H27ClN2O2. Mole weight: 362.90.
Ochratoxin A is a chlorinated benzopyran coupled to the amino acid phenylalanine, produced by several Aspergillus and Penicillium sp. associated with food spoilage. Ochratoxins are widely distributed in the environment and are known to be nephrotoxic, teratogenic and possibly carcinogenic. Ochratoxin A may act by induction of DNA strand breaks, sister chromatid exchanges, DNA adduct formation, or reactive oxygen but the mechanism of action as a toxin is not yet resolved. At the molecular level, ochratoxin A has been shown to specifically inhibit NK cell activity, increase growth of transplantable tumor cells in mice, increase apoptosis, activate c-Jun N terminal kinase in human kidney epithelial cells, and block metaphase/anaphase transition. It also inhibits plasminogen activator inhibitor-2 production by human blood mononuclear cells. Source:Aspergillus ochraceus MST-FP2005. Group: Biochemicals. Alternative Names: OTA; Ochratoxin A; Aspergillus ochraceus; N-[[(3R)-5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-phenylalanine; (-)-N-[(5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-3-phenylalanine; (R)-N-[(5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-benzo[c]pyran-7-yl)carbon. Grades: Highly Purified. CAS No. 303-47-9. Pack Sizes: 1mg. Molecular Formula: C??H??ClNO?, Molecular Weight: 403.8. US Biological Life Sciences.
Worldwide
Orciprenaline
Orciprenaline is a moderately selective beta-adrenergic agonist used in the treatment of asthma and bronchospasms. It stimulates receptors of the smooth muscle in the lungs, uterus, and vasculature supplying skeletal muscle, with minimal or no effect on alpha-adrenergic receptors. It is believed to work by activating adenylate cyclase, the enzyme responsible for producing the cellular mediator cAMP. It was developed by Boehringer-Ingelheim and has been withdraw from the market. Uses: Orciprenaline is used in the treatment of asthma and bronchospasms. Synonyms: Metaproterenol;Alupent;Metaprel;5-[1-Hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,3-diol;Astmopent;1-(3,5-dihydroxyphenyl)-2-isopropylaminoethanol;1,3-Benzenediol, 5-1-hydroxy-2-(1-methylethyl)aminoethyl-;3,5-Dihydroxy-a-[(isopropylamino)methyl]benzyl alco. Grades: 95%. CAS No. 586-06-1. Molecular formula: C11H17NO3. Mole weight: 211.26.
Parathion-methyl
Parathion-methyl. Group: Biochemicals. Alternative Names: Paratuf; Penncap M; Penncap MLS; Probel MP 2; Quinophos; Sinafid M 48; Thiophenit; Vofatox; Wofatox; Yphos; 8056HC; Azofos; Azophos; Azophos (pesticide); BAY 11405; Bravik; Bravik 600CE; Dalf; Demethylfenitrothion; Dimethyl 4-Nitrophenyl Phosphorothioate; Dimethyl p-Nitrophenyl Phosphorothionate; Dimethyl p-Nitrophenyl Thiophosphate; Dimethyl Parathion; Folidol 600; Folidol M; Folidol M 40; Folidol M 50; Folisuper 600BR; M-Parathion; ME 1605; ME 605; Me 605SP; Mentox 600CE; Meptox; Metacid; Metacid 50; Metacide; Metacide (insecticide); Metafos; Metafos (pesticide); Metaphos; Methion 48EC; Methyl 1605; Methyl 4E; Methyl Bladan; Methyl E 605; Methyl Parathion; Methylthiophos; Metron; Metron (pesticide); Morphos; Nitrox; Nitrox 80; O,O-Dimethyl O-(4-Nitrophenyl) Phosphorothioate; O,O-Dimethyl O-(4-Nitrophenyl) Thiophosphate; O,O-Dimethyl O-(p-Nitrophenyl) Phosphorothioate; O,O-Dimethyl O-(p-Nitrophenyl) Thiophosphate; Oleovofotox; Parataf; Parathion M; Parathion Methyl Homolog. Grades: Highly Purified. CAS No. 298-00-0. Pack Sizes: 500mg. Molecular Formula: C8H10NO5PS, Molecular Weight: 263.209999999999. US Biological Life Sciences.
PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4/SMAD4) deficient tumors. PC-046 has growth inhibitory activity in a variety of tumor types in vitro, and efficacy in SCID mice was shown in human tumor xenografts of MV-4-11 acute myeloid leukemia, MM.1S multiple myeloma, and DU-145 prostate cancer. Pharmacokinetic studies demonstrated relatively high oral bioavailability (71 %) with distribution to both plasma and bone marrow. No myelosuppression was seen in non-tumor bearing SCID mice given a single dose just under the acute lethal dose. The COMPARE algorithm in the NCI-60 cell line panel demonstrated that PC-046 closely correlated to other known tubulin destabilizing agents (correlation coefficients ?0.7 for vincristine and vinblastine). Mechanism of action studies showed cell cycle arrest in metaphase and inhibition of tubulin polymerization. Overall, these studies show that PC-046 is a synthetically-derived, small molecule microtubule destabilizing agent. Advantages over existing microtubule destabilizing agents include ease of synthesis, lack of MDR cross-resistance, good oral bioavailability and the lack of acute myelotoxicity. Synonyms: PC 046; PC046; NSC-756784; 5-(4-methoxyphenyl)-2-(3-(3-methoxyphenyl)pyridin-4-yl)oxazole. Grades: 98%. CAS No. 1202401-59-9. Molecular formula: C22H18N2O3. Mole weight: 358.39.
Potent microtubule assembly inhibitor. Anticancer compound. Cell death inducer. DNA topoisomerase II inhibitor. Cell cycle inhibitor at the metaphase. Antiviral and antihelminthic. Group: Biochemicals. Alternative Names: Podofilox, NSC 24818, Podophyllinic acid lactone. Grades: Highly Purified. CAS No. 518-28-5. Pack Sizes: 100mg. US Biological Life Sciences.
PPI-2458 is a potent, orally active, selective and irreversible inhibitor of methionine aminopeptidase-2 ( MetAP-2 ). PPI-2458 can be used for arthritis and lymphoma research [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 431077-35-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-13731.
PPI-2458
PPI-2458 is a synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth and angiogenesis. PPI-2458 is reported to have a better toxicity profile compared to other agents of its class. Synonyms: PPI 2458; PPI2458; Metapro; NSC-720735. CAS No. 431077-35-9. Molecular formula: C22H36N2O6. Mole weight: 424.54.
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