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| Product | Description | |
|---|---|---|
| Methyl arachidate | Methyl arachidate is a natural compound which can be isolated from Lepidium meyenii, Begonia heracleifolia, etc. Synonyms: Methyl eicosanoate; Arachidic acid methyl ester; Eicosanoic acid, methyl ester. Grades: 98%. CAS No. 1120-28-1. Molecular formula: C21H42O2. Mole weight: 326.56. |  |
| Methyl arachidate | Methyl arachidate (Methyl eicosanoate), a natural compound, is a leukotriene A4 hydrolase (LTA4H) inhibitor [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Methyl icosanoate. CAS No. 1120-28-1. Pack Sizes: 500 mg. Product ID: HY-W004291. |  |
| Methyl eicosanoate | Methyl eicosanoate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Eicosanoic acid methyl ester. Product Category: Heterocyclic Organic CompoundFatty Acids and Ester Homologs. Appearance: Solid. CAS No. 1120-28-1. Molecular formula: C21H42O2. Mole weight: 326.57. Purity: 99%+. Product ID: ACM1120281. Alfa Chemistry ISO 9001:2015 Certified. Categories: Methyl arachidate. |  |
| 15-Methylhexadeca Sphinganine | The major sphinganine from the ceramides phospholipids of Bacteroides melaninogenicus as arachidonate cascade inhibitor and blood platelet aggregation inhibitor. Group: Biochemicals. Alternative Names: [R-(R*,S*)]-2-Amino-15-methyl-1,3-hexadecanediol; D-erythro- 2-Amino-15-methyl-1,3-hexadecanediol; D-erythro-C17-iso-Sphinganine. Grades: Highly Purified. CAS No. 26048-10-2. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| 2-Linoleoyl glycerol | 2-Linoleoyl glycerol (2-Monolinolein; 2-Monolinoleoylglycerol) is a monoacylglycerol that is an antagonist and partial agonist at the type 1 cannabinoid CB1 receptor. The potency of 2-Linoleoyl glycerol can be enhanced by JZL195 (HY-15250), an inhibitor of FAAH and MAGL, and inhibited by the CB1 antagonist AM251 (HY-15443) and Cannabidiol. As a CB1 antagonist, 2-Linoleoyl glycerol does not enhance, but only attenuates, the activity of the CB1/CB2 receptor ligands cannabinoids (AEA) and 2-arachidonoylglycerol (2-AG) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-Monolinolein; 2-Monolinoleoylglycerol. CAS No. 3443-82-1. Pack Sizes: 500 μg (14.10 mM * 100 μL in Methyl acetate); 1 mg (14.10 mM * 200 μL in Methyl acetate). Product ID: HY-130311. | |
| (±)-2-Methyl Arachidonoyl-2'-Fluoroethylamide | (±)-2-Methyl arachidonoyl-2'-fluoroethylamide (2-Methyl-2'-fluoro AEA) is an analog of anandamide (AEA) in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom. An analog of arachidonylethanolamide that is a strong, selective CB1 cannabinoid receptor agonist. Synonyms: 2-methyl-2'-fluoro AEA; 2-Methyl-2'-fluoro Anandamide; O-689; (A+/-)-2-Methylarachidonoyl-2'-fluoroethylamide N-(2-fluoroethyl)-2-methylicosa-5,8,11,14-tetraenamide. Grades: ≥95%. CAS No. 166100-39-6. Molecular formula: C23H38FNO. Mole weight: 363.6. | |
| (5Z,8Z,11Z,14Z)-2-[[Tris(1-methylethyl)silyl]oxy]-5,8,11,14-eicosatetraenoic Acid 1-[[[Tris (1-methylethyl) silyl]oxy]methyl]ethyl Ester | (5Z,8Z,11Z,14Z)-2-[[Tris(1-methylethyl)silyl]oxy]-5,8,11,14-eicosatetraenoic Acid 1-[[[Tris (1-methylethyl) silyl]oxy]methyl]ethyl Ester is an intermediate in the synthesis of 2-Arachidonoylglycerol (A765050), an major endocannabinoid, which can inhibit synaptic transmission by presynaptic cannabinoid CB1 receptors. Group: Biochemicals. Grades: Highly Purified. CAS No. 223259-26-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| A 425619 | A 425619 is a potent and selective TRPV1 antagonist (IC50 = 3-9 nM) that inhibits TRPV1 activation by anandamide and N-arachidonoyl-dopamine. A 425619 exhibits an inhibitory effect against inflammatory, postoperative and osteoarthritic in vivo pain models. Uses: Analgesic. Synonyms: A-425619; A 425619; A425619; N-5-Isoquinolinyl-N'-[[(4-(trifluoromethyl)phenyl]methyl]urea. Grades: ≥98% by HPLC. CAS No. 581809-67-8. Molecular formula: C18H14F3N3O. Mole weight: 345.32. | |
| ACEA | ACEA (short for arachidonyl-2'-chloroacetamide) is a synthetic organic compound that acts as an agonist of the cannabinoid receptor CB1. It is a chemical that affects the endocannabinoid system in the body, which regulates various physiological processes such as appetite, pain perception, mood, and memory [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Arachidonyl-2-chloroethylamide. CAS No. 220556-69-4. Pack Sizes: 5 mg (68.31 mM * 200 μL in Methyl acetate); 10 mg (68.31 mM * 400 μL in Methyl acetate); 25 mg (68.31 mM * 1 mL in Methyl acetate); 50 mg (68.31 mM * 2 mL in Methyl acetate). Product ID: HY-110004. | |
| acyl-CoA (8-3)-desaturase | The enzyme introduces a cis double bond at carbon 5 of acyl-CoAs that contain a double bond at position 8. The enzymes from algae, mosses, mammals and the protozoan Leishmania major catalyse the desaturation of dihomo-γ-linoleate [(8Z,11Z,14Z)-icosa-8,11,14-trienoate] and (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoate to generate arachidonate and (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate, respectively. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the desaturase active site and does not require an external cytochrome. cf. EC 1.14.19.37, acyl-CoA 5-desaturase. Group: Enzymes. Synonyms: FADS1 (gene name); acyl-CoA 5-desaturase (methylene-interrupted). Enzyme Commission Number: EC 1.14.19.44. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1009; acyl-CoA (8-3)-desaturase; EC 1.14.19.44; FADS1 (gene name); acyl-CoA 5-desaturase (methylene-interrupted). Cat No: EXWM-1009. |  |
| acyl-lipid ω-3 desaturase (cytochrome b5) | This microsomal enzyme introduces a cis double bond three carbons away from the methyl end of a fatty acid incorporated into a glycerolipid. The distance from the carboxylic acid end of the molecule does not have an effect. The plant enzyme acts on carbon 15 of linoleoyl groups incorporated into both the sn-1 and sn-2 positions of the glycerol backbone of phosphatidylcholine and other phospholipids, converting them into α-linolenoyl groups. The enzyme from the fungus Mortierella alpina acts on γ-linolenoyl and arachidonoyl groups, converting them into stearidonoyl and icosapentaenoyl groups, respectively. cf. EC 1.14.19.35, acyl-lipid ω-3 desaturase (ferredoxin). Group: Enzymes. Synonyms: FAD3. Enzyme Commission Number: EC 1.14.19.25. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0988; acyl-lipid ω-3 desaturase (cytochrome b5); EC 1.14.19.25; FAD3. Cat No: EXWM-0988. | |
| (all-Z) -5, 8, 11, 14-Eicosatetraenyl phosphonofluoridic Acid Methyl Ester | (all-Z) -5, 8, 11, 14-Eicosatetraenyl phosphonofluoridic Acid Methyl Ester. Group: Biochemicals. Alternative Names: P-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-ylphosphonofluoridic Acid Methyl Ester; Methyl Arachidonyl Fluorophosphonate. Grades: Highly Purified. CAS No. 188404-10-6. Pack Sizes: 5mg. Molecular Formula: C21H36FO2P, Molecular Weight: 370.48. US Biological Life Sciences. | Worldwide |
| Apricoxib | Apricoxib is an orally bioavailable nonsteroidal anti-inflammatory agent (NSAID) with potential antiangiogenic and antineoplastic activities. Apricoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), thereby inhibiting the conversion of arachidonic acid into prostaglandins. Apricoxib-mediated inhibition of COX-2 may induce tumor cell apoptosis and inhibit tumor cell proliferation and tumor angiogenesis. Synonyms: CS-701; CS 701; CS701; TG01; TG 01; TG-01; R-109339, R 109339; R109339; Benzenesulfonamide, 4-[2-(4-ethoxyphenyl)-4-methyl-1H-pyrrol-1-yl]-. CAS No. 197904-84-0. Molecular formula: C19H20N2O3S. Mole weight: 356.44. | |
| Arachidic Acid Methyl Ester | Arachidic Acid Methyl Ester is used in biological studies to evaluate the antioxidant activity and chemical compounds of Capsicum annuum acuminatum during fruit ripening. This is the methyl analog of arachidic acid, which is used for the production of detergents, photographic materials and lubricants. Group: Biochemicals. Grades: Highly Purified. CAS No. 1120-28-1. Pack Sizes: 1g, 5g. Molecular Formula: C21H42O2. US Biological Life Sciences. | Worldwide |
| Arachidic Acid Methyl Ester-d3 | Arachidic Acid Methyl Ester-d3 is an isotope analog of Arachidic Acid Methyl Ester. Arachidic Acid Methyl Ester is used in biological studies to evaluate the antioxidant activity and chemical compounds of Capsicum annuum acuminatum during fruit ripening. This is the methyl analog of arachidic acid, which is used for the production of detergents, photographic materials and lubricants. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 100mg. Molecular Formula: C21H39D3O2, Molecular Weight: 329.58. US Biological Life Sciences. | Worldwide |
| Arachidonic acid-d8 | Arachidonic acid-d 8 is the deuterium labeled Arachidonic acid. Arachidonic acid is an essential fatty acid and a major constituent of biomembranes[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Immunocytophyt-d8. CAS No. 69254-37-1. Pack Sizes: 1 mg (32.00 mM * 100 μL in Methyl acetate). Product ID: HY-109590S. | |
| Arachidonoyl-N-methyl amide | Anandamide (N-arachidonylethanolamine, AEA) is a brain lipid that binds to cannabinoid receptors with high affinity and mimics the psychoactive effects of plant-derived cannabiniod drugs, which is a fatty acid neurotransmitter derived from the non-oxidative metabolism of eicosatetraenoic acid (arachidonic acid), an essential omega-6 fatty acid. Anandamide inhibits the specific binding of [3H]-HU-243 to synaptosomal membranes with a Ki value of 52 nM. Arachidonoyl-N-methyl amide is an analog of anandamide that binds to the human central cannabinoid (CB1) receptor with a Ki of 60 nM. It inhibits rat glial gap junction cell-cell communication 100% at a concentration of 50 μM. Synonyms: (5Z,8Z,11Z,14Z)-N-methyl-5,8,11,14-Eicosatetraenamide; N-Methylarachidonamide; (all-Z)-N-methyl-5,8,11,14-Eicosatetraenamide. Grades: ≥98%. CAS No. 156910-29-1. Molecular formula: C21H35NO. Mole weight: 317.5. | |
| Arachidonoyl p-nitroaniline | Arachidonoyl p-nitroaniline. Uses: Designed for use in research and industrial production. Additional or Alternative Names: APNA;ARACHIDONOYL P-NITROANILINE;N-(4-NITROPHENYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE. Product Category: Heterocyclic Organic Compound. Appearance: A solution in methyl acetate. CAS No. 119520-58-0. Molecular formula: C26H36N2O3. Mole weight: 424.58. Purity: 0.96. IUPACName: N-(4-nitrophenyl)icosa-5,8,11,14-tetraenamide. Canonical SMILES: CCCCCC=CCC=CCC=CCC=CCCCC(=O)NC1=CC=C(C=C1)[N+](=O)[O-]. Product ID: ACM119520580. Alfa Chemistry ISO 9001:2015 Certified. | |
| CK-2130 | CK-2130 is a bio-active imidazolone developed to treat congestive heart failure. It inhibited human platelet aggregation produced by adenosine diphosphate and sodium arachidonate. Uses: Ck-2130 is used to treat congestive heart failure. Synonyms: CK 2130; CK-2130; CK2130. 4-Ethyl-1,3-dihydro-5-[4-[(2-methyl-1H-imidazol)-1-yl]benzoyl]-2H-imidazol-2-one;CK2130;4-Ethyl-5-[4-(2-methylimidazol-1-yl)benzoyl]-1,3-dihydroimidazol-2-one. Grades: >98 %. CAS No. 101184-07-0. Molecular formula: C16H16N4O2. Mole weight: 296.33. | |
| CP 24,879 hydrochloride | CP 24,879 is an inhibitor of arachidonic acid biosynthesis by inhibition of Δ5/Δ6 desaturase. Synonyms: p-(Isopentyloxy)-aniline; 4-(3-methylbutoxy)-benzenamine monohydrochloride. Grades: ≥98%. CAS No. 10141-51-2. Molecular formula: C11H17NO·HCl. Mole weight: 215.8. | |
| Ec2la | Ec2la is a positive allosteric modulator of CB2 receptor. It enhances CP 55940 and 2-Arachidonylglycerol-stimulated binding of [35S]GTPγS to CB2 receptors, but doesn't have effect in the absence of agonist. Synonyms: N-[5-Bromo-1-[(4-fluorophenyl)methyl]-1,2-dihydro-4-methyl-2-oxo-3-pyridinyl]cycloheptanecarboxamide. Grades: ≥98% by HPLC. CAS No. 2244579-87-9. Molecular formula: C21H24BrFN2O2. Mole weight: 435.33. | |
| Eicosapentaenoic acid | Important polyunsaturated fatty acid of the marine food chain that serves as a precursor for the prostaglandin-3 and thromboxane-3 families. It differs from arachidonic acid (the eicosatetraenoic acid that is a precursor for the prostaglandin and thromboxane-2 families) by the extra double bond between the third and fourth carbons from the methyl end of the molecule. Antilipemic. Group: Biochemicals. Alternative Names: (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-Eicosapentaenoic Acid; (all-Z)-5,8,11,14,17-Eicosapentaenoic Acid; EPA; EPA 45G; Icosapent; Icosapentaenoic Acid; Incromega E 7010SR; Ropufa 70; Timnodonic Acid. Grades: Highly Purified. CAS No. 10417-94-4. Pack Sizes: 10g. Molecular Formula: C20H30O2, Molecular Weight: 302.45. US Biological Life Sciences. | Worldwide |
| Heneicosapentaenoic acid methyl ester | Heneicosapentaenoic acid methyl ester is a derivative of heneicosapentaenoic acid (HPA), a 21:5 ω-3 fatty acid found in the green alga B. pennata and in fish oils. HPA is incorporated into phospholipids and into triacylglycerol in cell culture and inhibits the conversion of linolenic acid to arachidonic acid (AA) in hepatoma cells. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and for 5-lipoxygenase. Synonyms: HPA methyl ester; Methyl 6,9,12,15,18-heneicosapentaenoate; (all-Z)-6,9,12,15,18-heneicosapentaenoic acid methyl ester; (6Z,9Z,12Z,15Z,18Z)-6,9,12,15,18-henicosapentaenoic acid methyl ester. Grades: ≥98%. CAS No. 65919-53-1. Molecular formula: C22H34O2. Mole weight: 330.5. | |
| Hydroxy Loxoprofen | An impurity of Loxoprofen. Loxoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduce the synthesis of prostaglandins from arachidonic acid. Synonyms: Benzeneacetic acid, 4-[(2-hydroxycyclopentyl)?methyl]?-α-methyl-. Grades: >95%. CAS No. 83599-40-0. Molecular formula: C15H20O3. Mole weight: 248.32. | |
| KML-29 | KML-29 is an extremely specific monoacylglycerol lipase (MAGL) inhibitor. KML-2 should be useful to distinguish between actions of 2-arachidonoyl glycerol (an endogenous ligand of cannabinoid receptors that is deactivated by MAGL) and anandamide, another endocannabinoid. Group: Biochemicals. Alternative Names: 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic Acid 2,2,2-Trifluoro-1-(trifluoromethyl)ethyl Ester; 1,1,1,3,3,3-Hexafluoropropan-2-yl 4- (Bis (benzo[d][1, 3]dioxol-5-yl) (hydroxy) methyl) piperidine-1-carboxylate; KML29. Grades: Highly Purified. CAS No. 1380424-42-9. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Leukotriene E4 methyl ester | Leukotriene E4 methyl ester is a derivate of Leukotriene E4, which is a cysteinyl leukotriene produced by LTD4 and LTC4 in breath condensation, plasma, and urine. It is a constituent of slow-reacting substance of anaphylaxis (SRS-A). It is the final product of the pathway where 5-lipoxygenase converts arachidonic acid to cysteinyl leukotrienes, thus it can be used as an indicator in clinical diagnosis of asthma. Synonyms: 7,9,11,14-Eicosatetraenoic acid, 6-[[(2R)-2-amino-2-carboxyethyl]thio]-5-hydroxy-, 1-methyl ester, (5S,6R,7E,9E,11Z,14Z)-; 1-Methyl (5S,6R,7E,9E,11Z,14Z)-6-[[(2R)-2-amino-2-carboxyethyl]thio]-5-hydroxy-7,9,11,14-eicosatetraenoate; 7,9,11,14-Eicosatetraenoic acid, 6-[(2-amino-2-carboxyethyl)thio]-5-hydroxy-, 1-methyl ester, [5S-[5R*,6S*(S*),7E,9E,11Z,14Z]]-; S-((5S,6R,7E,9E,11Z,14Z)-5-hydroxy-1-methoxy-1-oxoicosa-7,9,11,14-tetraen-6-yl)-L-cysteine; LTE4, methyl ester; leukotriene E4 monomethyl ester. Grades: ≥95%. CAS No. 89461-65-4. Molecular formula: C24H39NO5S. Mole weight: 453.64. | |
| Loxoprofen | Loxoprofen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. It is a non-selective cyclooxygenase inhibitor, and works by reducing the synthesis of prostaglandins from arachidonic acid. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: α-Methyl-4-[(2-oxocyclopentyl)methyl]benzeneacetic Acid; 2-[4-[(2-Oxocyclopentan-1-yl)methyl]phenyl]propionic Acid; 2-[4-[ (2-Oxocyclopentyl) methyl]phenyl]propionic Acid. Grades: >98%. CAS No. 68767-14-6. Molecular formula: C15H18O3. Mole weight: 246.3. | |
| MAFP | MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor of cPLA2 and iPLA2. MAFP is also a potent irreversible inhibitor of anandamide amidase. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Methyl Arachidonyl Fluorophosphonate. CAS No. 188404-10-6. Pack Sizes: 1 mg (26.99 mM * 100 μL in Methyl acetate). Product ID: HY-103334. | |
| Methyl α-Linolenyl Fluorophosphonate | Methyl α-linolenyl fluorophosphonate (MLnFP) is an analog of methyl arachidonyl fluorophosphonate (MAFP), an inhibitor of PLA2, FAAH and CB1 receptor. Synonyms: MαLnFP; Methyl alpha-Linolenyl Fluorophosphonate; (3Z,6Z,9Z)-18-[fluoro(methoxy)phosphoryl]octadeca-3,6,9-triene. Grades: ≥98%. Molecular formula: C19H34FO2P. Mole weight: 344.4. | |
| Methyl arachidonate | ?99% (GC). Group: Fluorescence/luminescence spectroscopy. |  |
| Methyl arachidonyl fluorophosphonate | ?98%, methyl acetate solution (10 mg/mL). Group: Fluorescence/luminescence spectroscopy. | |
| Methyl Arachidonyl Fluorophosphonate | Methyl arachidonyl fluorophosphonate (MAFP) is a selective and irreversible inhibitor of PLA2 and FAAH. It also binds to CB1 receptor in rat brain membrane preparations. Uses: Enzyme inhibitors. Synonyms: MAFP; (5Z,8Z,11Z,14Z)-1-[fluoro(methoxy)phosphoryl]icosa-5,8,11,14-tetraene. Grades: ≥98%. CAS No. 188404-10-6. Molecular formula: C21H36FO2P. Mole weight: 370.5. | |
| Methyl γ-Linolenyl Fluorophosphonate | Methyl γ-Linolenyl Fluorophosphonate (MLnFP) is an analog of methyl arachidonyl fluorophosphonate (MAFP), an inhibitor of PLA2, FAAH and CB1 receptor. Synonyms: MγLnFP; Methyl gamma-Linolenyl Fluorophosphonate; (6Z,9Z,12Z)-1-[fluoro(methoxy)phosphoryl]octadeca-6,9,12-triene. Grades: ≥98%. CAS No. 1370451-91-4. Molecular formula: C19H34FO2P. Mole weight: 344.4. | |
| MJN110 | MJN110 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor that modulates the synaptic processes. MJN110 has the potential for the treatment of acute nausea and vomiting as well as anticipatory nausea by elevation of endogenous cannabinoid 2-arachidonoylglycerol (2-AG) levels in the brain. Uses: Antihyperalgesic agent. Synonyms: MJN-110; MJN 110; MJN110;2,5-dioxopyrrolidin-1-yl 4-(bis(4-chlorophenyl)methyl)piperazine-1-carboxylate. Grades: 98%. CAS No. 1438416-21-7. Molecular formula: C22H21Cl2N3O4. Mole weight: 462.33. | |
| Nafazatrom | Nafazatrom is a pyrazolinone derivative. It increases endogenous prostacyclin (PGI2) and has potential antimetastatic activities. It is used an antithrombotic drug that increases PGI2 levels. It inhibits the key prostaglandin catabolic enzyme, 15-hydroxyprostaglandin dehydrogenase, which prolongs the biological half-life of PGI2 and prevents intravascular coagulation. It also serves as a reducing cofactor with the hydroperoxidase moiety of cyclooxygenase and accelerates the conversion of arachidonic acid into precursors of PGI2. It is a lipoxygenase inhibitor, reduces stimulated Prolactin secretion. It also reduces the incidence of accompanying arrhythmias in myocardial injuries. Uses: Nafazatrom is used an antithrombotic drug. Synonyms: 2,4-Dihydro-5-methyl-2-[2-(2-naphthalenyloxy)ethyl]-3H-pyrazol-3-one; Bay-g-6575; BAY g 6575; 3-methyl-1-(2-(naphthalen-2-yloxy)ethyl)-1H-pyrazol-5(4H)-one. Grades: 98%. CAS No. 59040-30-1. Molecular formula: C16H16N2O2. Mole weight: 268.32. | |
| N-Arachidonoylserotonin | N-Arachidonoylserotonin (Arachidonyl serotonin; AA-5-HT) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC 50 value of 1~12 μM. N-Arachidonoylserotonin acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels (IC 50 =70~100 nM). N-Arachidonoylserotonin is analgesic in rodents [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Arachidonyl serotonin; AA-5-HT. CAS No. 187947-37-1. Pack Sizes: 5 mg (108.07 mM * 0.1 mL in methyl acetate); 10 mg (108.07 mM * 0.2 mL in methyl acetate); 25 mg (108.07 mM * 0.5 mL in methyl acetate); 50 mg (108.07 mM * 1 mL in methyl acetate). Product ID: HY-103337. | |
| Nidulin (Methylustin) | Nidulin is a depsidone produced by several fungal species with potent and selective antibacterial activity. While literature relating to nidulin is limited, it is closely related to folipasatin and unguinol identified as inhibitors of phospholipase A2, arachidonic acid release from rat polymorphonuclear leukocytes and nitrendipine binding to porcine heart membrane. While showing some calcium blocking attributes these metabolites have potential as antiinflammatory agents. Group: Biochemicals. Alternative Names: Methylustin. Grades: Highly Purified. CAS No. 10089-10-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| O-7460 | O-7460 is a selective inhibitor of 2-arachidonoyl glycerol (2-AG) biosynthesis via diacylglycerol lipase (DAGL). O-7460 dose-dependently inhibited the intake of a high-fat diet and reduced body weight in mice. Synonyms: [1-[fluoro(methyl)phosphoryl]oxy-3-propan-2-yloxypropan-2-yl] (Z)-octadec-9-enoate. Grades: ≥95%. CAS No. 1572051-31-0. Molecular formula: C25H48FO5P. Mole weight: 478.6. | |
| Phosphonofluoridicacid,p-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-,methyl ester | Phosphonofluoridicacid,p-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-,methyl ester. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CHEMBL113262, methylarachidonyl fluorophosphonate, MAFP, KWKZCGMJGHHOKJ-ZKWNWVNESA-N, MolPort-003-983-617, 188404-10-6, Methoxyarachidonoyl Fluorophosphonate, Methyl Arachidonoyl Fluorophophonate, DNC009979, HSCI1_000023, AKOS024456588, NCGC00162418-01, LS-192336, 5Z,8Z,11Z,14Z-Eicosatetraenyl-phosphonofluoridic acid, methyl ester, (5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenyl-methyl ester phosphonofluoridic acid, Phosphonofluoridic acid, P-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-, methyl ester. Product Category: Heterocyclic Organic Compound. CAS No. 188404-10-6. Molecular formula: C21H36FO2P. Mole weight: 370.48. Purity: 0.96. IUPACName: (5Z,8Z,11Z,14Z)-1-[fluoro(methoxy)phosphoryl]icosa-5,8,11,14-tetraene. Canonical SMILES: CCCCCC=CCC=CCC=CCC=CCCCCP(=O)(OC)F. Product ID: ACM188404106. Alfa Chemistry ISO 9001:2015 Certified. | |
| polyenoic fatty acid isomerase | The enzyme from the red alga Ptilota filicina catalyses the isomerization of skip dienes (methylene-interrupted double bonds) in a broad range of fatty acids and fatty-acid analogues, such as arachidonate and γ-linolenate, to yield a conjugated triene. Group: Enzymes. Synonyms: PFI; eicosapentaenoate cis-Δ5,8,11,14,17-eicosapentaenoate cis-Δ5-trans-Δ7,9-cis-Δ14,17 isomerase; (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Δ8,11-Δ7,8-isomerase (incorrect); (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Δ8,11-Δ7,9-isomerase (trans-double-bond-forming). Enzyme Commission Number: EC 5.3.3.13. CAS No. 159002-84-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5493; polyenoic fatty acid isomerase; EC 5.3.3.13; 159002-84-3; PFI; eicosapentaenoate cis-Δ5,8,11,14,17-eicosapentaenoate cis-Δ5-trans-Δ7,9-cis-Δ14,17 isomerase; (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Δ8,11-Δ7,8-isomerase (incorrect); (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Δ8,11-Δ7,9-isomerase (trans-double-bond-forming). Cat No: EXWM-5493. | |
| Pyrrophenone | Pyrrophenone is an inhibitor of cytosolic phospholipase A2α (cPLA2α) with an IC50 of 4.2 nM in enzyme assays. It potently inhibited arachidonic acid release in calcium ionophore (A23187)-stimulated human monocytic cells (THP-1 cells) in a dose-dependent manner with IC50 value of 0.024 mM. Synonyms: N-[[(2S,4R)-1-[2-(2,4-Difluorobenzoyl)benzoyl]-4-tritylsulfanylpyrrolidin-2-yl]methyl]-4-[(E)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzamide. Grades: ≥95%. CAS No. 341973-06-6. Molecular formula: C49H37F2N3O5S2. Mole weight: 850. | |
| Santin | Santin is a flavonoid compound found in Alnus japonica and Grindelia glutinosa. It has anti-inflammatory activity and inhibits cyclo-oxygenase and 5-lipoxygenase pathways of arachidonic metabolism. Synonyms: 2-(4-Methoxyphenyl)-5,7-dihydroxy-3,6-dimethoxy-4H-1-benzopyran-4-one; 3,4',6-Trimethoxy-5,7-dihydroxyflavone; 5,7-Dihydroxy-3,6,4'-trimethoxyflavone; 6-Hydroxykaempferol 3,4',6-trimethyl ether; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3,6-dimethoxy-2-(4-methoxyphenyl)-; Centauridin; 3-Methylbetuletol. Grades: ≥95%. CAS No. 27782-63-4. Molecular formula: C18H16O7. Mole weight: 344.32. | |
| SAR629 | SAR-629 is a Monoglyceride lipase (MGL) inhibitor and can also be known as 2-arachidonoylglycerol (2-AG) degradation inhibitor. MGL is a serine hydrolase which can hydrolyse 2-AG into arachidonic acid and glycerol. 2-AG is an endogenous ligand of cannabinoid receptors and it plays an important role in various physiological processes in the brain. Synonyms: (4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)(1H-1,2,4-triazol-1-yl)methanone. Grades: 98%. CAS No. 1221418-42-3. Molecular formula: C20H19F2N5O. Mole weight: 383.40. | |
| SC 57461A | SC 57461A is a potent, selective and orally bioactive inhibitor of leukotriene A4 (LTA4) hydrolase without inhibitory effects on other enzymes of the arachidonic acid cascade including COX-1, COX-2, LTC4 synthase and 5-lipoxygenase. SC 57461A inhibits LTB4 production in whole blood (IC50 = 49 nM). Synonyms: SC 57461; SC-57461; SC57461; SC 57461A; SC-57461A; SC57461A; N-methyl-N-[3-[4-(phenylmethyl)phenoxy]propyl]-β-alanine hydrochloride; 3-[3-(4-benzylphenoxy)propyl-methylamino]propanoic acid hydrochloride. Grades: ≥98% by HPLC. CAS No. 423169-68-0. Molecular formula: C20H25NO3.HCl. Mole weight: 363.88. | |
| Thromboxane A2 | Thromboxane A2 is the predominant cyclooxygenase product formed from arachidonic acid (AA) in human platelets. Thromboxane A2 is neither stored in platelets, nor formed in the absence of activation. However, it is synthesized in response to platelet activation by a wide variety of receptor-dependent and -independent platelet agonists. Synonyms: thromboxane A2; TXA2; 57576-52-0; TXA-2; Rabbit aorta contracting substance; 9S,11S-epoxy,15S-hydroxy-thromboxa-5Z,13E-dien-1-oic acid; 4C2A5G825S; Thromboxa-5,13-dien-1-oic acid, 9,11-epoxy-15-hydroxy-, (5Z,9alpha,11alpha,13E,15S)-; Benz(a)anthracene-1,7,12(2H)-trione, 3,4-dihydro-3,6,8-trihydroxy-3-methyl-, (-)-; (Z)-7-[(1S,3R,4S,5S)-3-[(E,3S)-3-hydroxyoct-1-enyl]-2,6-dioxabicyclo[3.1.1]heptan-4-yl]hept-5-enoic acid; (5Z,13E)-(15S)-9alpha,11alpha-Epoxy-15-hydroxythromboxa-5,13-dienoate; (5Z,9alpha,11alpha,13E,15S)-9,11-Epoxy-15-hydroxythromboxa-5,13-dien-1-oic acid. Grades: > 95%. CAS No. 57576-52-0. Molecular formula: C20H32O5. Mole weight: 352.48. | |
| Trequinsin hydrochloride | Trequinsin hydrochloride is a highly potent inhibitor of cGMP-inhibited phosphodiesterase (PDE3) (IC50 = 250 pM). Trequinsin stimulates cAMP accumulation at a concentration of 10 μM, and inhibits arachidonic acid-induced platelet aggregation (IC50 = 50 pM). Trequinsin was shown to decrease blood pressure levels in both normotensive and hypertensive animal models and is used as an antihypertensive agent. Uses: Antihypertensive agent. Synonyms: 2,3,6,7-Tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-4H-pyrimido[6,1-a]isoquinolin-4-one hydrochloride. Grades: ≥97% by HPLC. CAS No. 78416-81-6. Molecular formula: C24H27N3O3.HCl. Mole weight: 441.95. | |
| VDM 11 | VDM 11 is a potent and selective inhibitor of the anandamide membrane transporter (AMT) (IC50 = 4-11 μM), blocking cellular reuptake of anandamide and leads to inactivation of the endocannabinoid signal. VDM 11 also displays negligible agonist activity at the hVR1 receptor and weak action at CB1 and CB2 receptors. Synonyms: VDM 11; VDM11; VDM-11; (5Z,8Z,11Z,14Z)-N-(4-Hydroxy-2-methylphenyl)-5,8,11,14-eicosatetraenamide; N-(4-Hydroxy-2-methylphenyl)arachidonylamide. Grades: ≥98% by HPLC. CAS No. 313998-81-1. Molecular formula: C27H39NO2. Mole weight: 409.61. | |
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