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3-MATIDA is a potent metabotropic glutamate (mGlu1) receptor antagonist with IC50 value of 6.3 μM at rat mGlu1a. It displays ≥ 40-fold selectivity over other receptors. It has neuroprotective activity in cultured murine cortical cells and rat hippocampal slice cultures in vitro. It reduces the volume of ischemia-induced brain infarcts in rats following systemic administration in vivo. Synonyms: α-Amino-5-carboxy-3-methyl-2-thiopheneaceticacid; 5-[amino(carboxy)methyl]-4-methylthiophene-2-carboxylicacid; 3-Methyl-aminothiophene dicarboxylicacid. Grades: ≥99% by HPLC. CAS No. 518357-51-2. Molecular formula: C8H9NO4S. Mole weight: 215.23.
PCNA-I1 is a proliferating cell nuclear antigen (PCNA) inhibitor. It inhibits growth of a range of tumor cell lines in vitro. It induces S and G2/M phase cell cycle arrest in tumor cells with greater efficacy than non-transformed cells. Synonyms: PCNA I1; PCNA-I1; PCNAI1; N-(3-Methylthiophene-2-carboxylicacid)-N'-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide. Grades: ≥98% by HPLC. CAS No. 444930-42-1. Molecular formula: C17H14N2O2S. Mole weight: 310.37.
Tiagabine Impurity 6
An impurity of Tiagabine which is a selective gamma-aminobutyric acid (GABA) reuptake inhibitor. Synonyms: Desmethyltiagabine; Tiagabine impurity 6; TVX38N3FFG; UNII-TVX38N3FFG; Desmethyl tiagabine [USP]; 748741-38-0; (3R)-1-(4-(3-Methyl-2-thienyl)-4-(2-thienyl)-3-buten-1-yl)-3-piperidinecarboxylicacid; 3-Piperidinecarboxylicacid, 1-(4-(3-methyl-2-thienyl)-4-(2-thienyl)-3-buten-1-yl)-, (3R)-; (R,ZE)-1-(4-(3-Methylthiophen-2-yl)-4-(thiophen-2-yl)but-3-en-1-yl)piperidine-3-carboxylicacid; DESMETHYL TIAGABINE [USP IMPURITY]. Grades: > 95%. Molecular formula: C19H23NO2S2. Mole weight: 361.53.
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