Mi 2 Suppliers USA
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Product | Description | |
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MI-2 Quick inquiry Where to buy Suppliers range | MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM. Synonyms: MI-2 ; Menin-MLL inhibitor 2; Menin-MLL Inhibitor. Grades: >98%. CAS No. 1271738-62-5. Molecular formula: C18H25N5S2. Mole weight: 375.55. | |
MI-2 (MALT1 inhibitor) Quick inquiry Where to buy Suppliers range | MI-2 (350 mg/kg) is nontoxic to mice. MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor with IC50 of 5.84 μM. Synonyms: MI-2; MI 2; MI2. Grades: >98%. CAS No. 1047953-91-2. Molecular formula: C19H17Cl3N4O3. Mole weight: 455.72. | |
MALT1 Inhibitor I, MI-2 (ALB-H03200218, 2-Chloro-N-(4-(5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl)phenyl)acetamide) Quick inquiry Where to buy Suppliers range | A cell-permeable chloromethyl amide that inhibits MALT1 proteolytic activity (IC50 = 5.84uM against MALT1 paracaspase domain dimer-catalyzed Ac-LRSR-AMC hydrolysis) in an irreversible manner via covalent interaction, displaying little or no activity against caspase-3, -8, or -9. Due to irreversible binding and effective intracellular accumulation (HBL-1 intracellular [MI-2]t = 2h = 5uM; Medium [MI-2]t = 0 = 0.2uM), MI-2 is at least 250-times more effective than Z-VRPR-FMK in blocking constitutive NF-kappaB activity and c-Rel nuclear translocation in HBL-1 cultures (equal or better blockage by 200nM MI-2 than by 50uM Z-VRPR-FMK). Shown to selectively inhibit MALT1-dependent ABC-DLBCL proliferation, but not the MALT1-independent growths of ABC- (HLY-1 and U2932) or GCB-DLBCL (OCI-Ly1 and OCI-Ly7) cells, both in cultures in vitro (GI50 in 48h = 200, 400, 400, and 500nM, respectively, against HBL-1, OCI-Ly3, OCI-Ly10, and TMD8) and in mice in vivo (65%,, 61%, and 0% suppression, respective Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Menin-MLL Interaction Inhibitor, MI-2-2 (MI22, 4- (4- (5, 5-Dimethyl-4, 5-dihydrothiazol-2-yl) piperazin-1-yl) -6- (2, 2, 2-trifluoroethyl) thieno[2, 3-d]pyrimidine, HCl) Quick inquiry Where to buy Suppliers range | A cell-permeable thienopyrimidine compound that competes against MLL (Mixed Lineage Leukemia) for menin binding (IC50 = 46 and 520nM, respectively, against MBM1 sequence MLL4-15 and MLL4-43 containing both MBM1 & MBM2) by targeting menin MLL-binding pocket with high affinity (KD = 22nM), effectively disrupting cellular menin and MLL-AF9 fusion interaction (by >90% at 12uM in MLL-AF9-expressing HEK293 cells). Shown to inhibit the oncogenic proliferation of four MLL translocation-harboring human leukemia cell lines (by >95% in 12 d at 6uM), but not non-MLL leukemia Kasumi-1 and HAL-01 lines (≤16% inhibition at 12uM), by downregulating MLL target genes expression via simultaneous hematopoietic differentiation induction and killing of non-differentiated population. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
1-Miristoyl-2-linoleoyl Glycerol 3-Phosphocholine Quick inquiry Where to buy Suppliers range | 1-Miristoyl-2-linoleoyl Glycerol 3-Phosphocholine is a glycerophospholipid. Group: Biochemicals. Grades: Highly Purified. CAS No. 92345-33-0. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C40H76NO8P, Molecular Weight: 730.01. US Biological Life Sciences. | Worldwide |
4-Nitrotoluene-2-sulfonic acid Quick inquiry Where to buy Suppliers range | 2-METHYL-5-NITROBENZENESULFONIC ACID, 121-03-9, 4-Nitrotoluene-2-sulfonic acid, p-Nitrotoluene-o-sulfonic acid, Pntos, 5-Nitro-o-toluenesulfonic acid, 4-Nitro-2-toluenesulfonic acid, 4-Nitrotoluene-2-sulphonic acid, Benzenesulfonic acid, 2-methyl-5-nitro-, 5-Nitro-2-methylbenzenesulfonic acid, o-Toluenesulfonic acid, 5-nitro-, Kyselina 4-nitrotoluen-2-sulfonova, NSC 9580, JBO1Z0PMOH, UNII-JBO1Z0PMOH, HSDB 5470, 2-Toluenesulfonic acid, 5-nitro, EINECS 204-445-3, p-nitrotoluol-o-sulfonic acid, BRN 2216176, p-nitrotoluene-o-sulphonic acid, 5-nitro-o-toluenesulphonic acid, 4-mitro-2-toluenesulphonic acid, DTXSID4026975, CHEBI:67120, NSC-9580, 2-methyl-5-nitrobenzenesulphonic acid, 5-nitro-2-methylbenzenesulphonic acid, 4-Nitrotoluene-2-sulfonic Acid Hydrate, DTXCID506975, Kyselina 4-nitrotoluen-2-sulfonova [Czech], EC 204-445-3, 3-11-00-00173 (Beilstein Handbook Reference), 2-TOLUENESULFONIC ACID, 5-NITRO-, 5-Nitro-o-toluenesulfonic acid; NSC 9580; PNTOS, CAS-121-03-9, p-Nitrotoluolsulfosaure, WLN: WSQR B1 ENW, p-Nitrotoluene-o-sulfonicacid, P-Nitrotoluene Sulphonic Acid, SCHEMBL709336, p-nitrotoluene-2-sulphonic acid, CHEMBL3183957, 2-methyl-5-nitrobenzenesulfonate, ZDTXQHVBLWYPHS-UHFFFAOYSA-, NSC9580, p-Nitro Toluene-2-Sulfonic Acid, CS-M3300, Tox21_202190, Tox21_303151, AKOS003241755, 2-methyl-5-nitro-1-benzenesulfonic acid, NCGC00249182-01, NCGC00257106-01, NCGC00259739-01, BS-22427, LS-32018, 4-nitrotoluene-2-sulfonic acid, AldrichCPR, FT-0619305, N0277, 2-METHYL-5-NITROBENZENESULFONIC ACID [HSDB], W-108462, Q27135631, 4-Nitrotoluene-2-sulfonic acid 10 microg/mL in Acetonitrile. | |
ABT-100 Quick inquiry Where to buy Suppliers range | ABT-100 is an orally bioavailable farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity. Synonyms: ABT 100; ABT100; A-367074; A 367074; A367074. Grades: >98%. CAS No. 450839-40-4. Molecular formula: C27H19F3N4O3. Mole weight: 504.47. | |
Diflorasone Diacetate Quick inquiry Where to buy Suppliers range | Diflorasone Diacetate is a salt of diflorasone, which is a corticosteroid used as anti-inflammatory and anti-itching agent in the topical creams. Diflorasone inhibits the production of the inflammatory cytokines Il-6, Il-4, and macrophage inflammatory protein-2 (Mip-2), and alleviates swelling in the ears of toluene-2,4-diisocyaniate-sensitized mice. Uses: Anti-inflammatory agent. Synonyms: Psorcon; Florone E; Maxiflor; Apexicon e. Grades: 99%. CAS No. 33564-31-7. Molecular formula: C26H32F2O7. Mole weight: 494.52. | |
Green Fluorescent PLGA Microspheres-20 μm Quick inquiry Where to buy Suppliers range | Excitation/Emission: 460/500 nm. Uses: Fluorescent PLGA particles for imaging and cell tracking in drug discovery. Particles can be used for fluorscent assays and drug delivery. Group: Polymer Microspheres. Alternative Names: Green Fluorescent PLGA nanoparticles. Pack Sizes: 50 mg. Product ID: MSMN-013. | |
Green Fluorescent PLGA Microspheres-25 μm Quick inquiry Where to buy Suppliers range | Excitation/emission: 460/500 nm. Uses: Fluorescent PLGA particles for imaging and cell tracking in drug discovery. Particles can be used for fluorscent assays and drug delivery. Group: Polymer Microspheres. Alternative Names: Green Fluorescent PLGA nanoparticles. Pack Sizes: 50 mg in poly bottle. Product ID: MSMN-014. | |
Green Fluorescent PLGA Microspheres-2 μm Quick inquiry Where to buy Suppliers range | Particles made of poly(D,L-lactide-co-glycolide) L/G ratio of 50/50, inherent viscosity of ~0.45 dL/gTo re-constitute: Warm to ambient temperature; Add DI water or buffer to achieve desired concentration; Vortex and sonicate for 5 minutes to ensure particles are well suspended. Uses: Fluorescent PLGA particles for imaging and cell tracking in drug discovery. Particles can be used for fluorscent assays and drug delivery. Group: Polymer Microspheres. Alternative Names: Green Fluorescent PLGA nanoparticles. Pack Sizes: 50 mg. Product ID: MSMN-011. | |
Lagociclovir Quick inquiry Where to buy Suppliers range | Lagociclovir is a prodrug of 3'-fluoro-2',3'-dideoxyguanosine with high oral bioavailability in humans and potent activity against HBV. Uses: Antiviral agents. Synonyms: MIV-210; MIV 210; MIV210; 3'-FddG; Fddguo; Lagociclovir. Grades: >98%. CAS No. 92562-88-4. Molecular formula: C10H12FN5O3. Mole weight: 269.23. | |
MI 2 dihydrochloride Quick inquiry Where to buy Suppliers range | MI 2 dihydrochloride is a Menin-MLL interaction inhibitor. MI-2 can bind menin and block the menin-MLL fusion protein interaction with IC50 value of 0.45 μM. It can selectively inhibit proliferation and induce apoptosis of leukemia cells harboring MLL fusion proteins. Synonyms: MI 2 dihydrochloride; MI2 dihydrochloride; MI-2 dihydrochloride; 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-propylthieno[2,3-d]pyrimidine dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C18H25N5S2.2HCl. Mole weight: 448.48. | |
Milbemectin a3 Quick inquiry Where to buy Suppliers range | white solid. Group: Main Products. Alternative Names: MILBEMECTIN A3;milbemycin;milbemycinb-2;milbemectine a3;milbemycin A3;(25R)-25-Methyl-5β-hydroxy-5-demethoxy-28-O,6β-cyclomilbemycin B;(6R,25R)-5-O-Demethyl-28-deoxy-6,28-epoxy-25-methylmilbemycin B;Antibiotic B-41A3. Grades: 95%+. CAS No. 51596-10-2. Molecular formula: C31H44O7. Mole weight: 528.68. IUPAC Name: milbemycin A3. Exact Mass: 528.30900. EC Number: 610-705-0. Boiling Point: 725.5ºC at 760mmHg. Flash Point: 233.1ºC. Density: 1.21g/cm3. SMILES: CC1CCC2 (CC3CC (O2)CC=C (CC (C=CC=C4COC5C4 (C (C=C (C5O)C)C (=O)O3)O)C)C)OC1C. InChIKey: ZLBGSRMUSVULIE-GSMJGMFJSA-N. | |
MIP-202 (Zr) Quick inquiry Where to buy Suppliers range | MIP-202 (Zr). Group: UIO-MOFs; Zr-MOFs. CAS No. 2378179-91-8. | |
PCL Microspheres-20 μm Quick inquiry Where to buy Suppliers range | PCL particles are made with poly(?-caprolactone) with a MW of 14,000.To re-constitute:Warm to ambient temperature; Add DI water or buffer to achieve desired concentration; Vortex and sonicate for 5 minutes to ensure particles are well suspended. Uses: Plain PCL particles for testing system compatibility in drug delivery research. Particles can be used as carriers by attaching drug or biological/chemical entities to particle surface. PCL particles are used for controlled release, sustained release and targeted drug delivery. Degradation rate of PCL is slower than PLGA. Group: Polymer Microspheres. Alternative Names: PCL Nanoparticles. Pack Sizes: 50 mg. Product ID: MSMN-019. | |
PLGA Microspheres-20 μm Quick inquiry Where to buy Suppliers range | Particles made of poly(D,L-lactide-co-glycolide) L/G ratio of 50/50, inherent viscosity of ~0.45 dL/gTo re-constitute: Warm to ambient temperature; Add DI water or buffer to achieve desired concentration; Vortex and sonicate for 5 minutes to ensure particles are well suspended. Uses: Plain PLGA particles for testing system compatibility in drug delivery research. Particles can be used as carriers by attaching drug or biological/chemical entities to particle surface. PLGA particles are used for controlled release, sustained release and targeted drug delivery. Group: Polymer Microspheres. Alternative Names: PLGA Nanoparticles. Pack Sizes: 50 mg. Product ID: MSMN-005. | |
PLGA Microspheres-25 μm Quick inquiry Where to buy Suppliers range | PLGA Microspheres-25 μm. Uses: Plain PLGA particles for testing system compatibility in drug delivery research. Particles can be used as carriers by attaching drug or biological/chemical entities to particle surface. PLGA particles are used for controlled release, sustained release and targeted drug delivery. Group: Polymer Microspheres. Alternative Names: PLGA Nanoparticles. Pack Sizes: 50 mg in poly bottle. Product ID: MSMN-006. | |
PLGA Microspheres-2 μm Quick inquiry Where to buy Suppliers range | To re-constitute: Remove the product from freezer.Wait until temperature rises to the ambient temperature.Add DI water or buffer to the container. Vortex and sonicate for 5 minutes to ensure the microspheres are well suspended. Uses: Plain PLGA particles for testing system compatibility in drug delivery research. Particles can be used as carriers by attaching drug or biological/chemical entities to particle surface. PLGA particles are used for controlled release, sustained release and targeted drug delivery. Group: Polymer Microspheres. Alternative Names: PLGA Nanoparticles. Pack Sizes: 50 mg in poly bottle. Product ID: MSMN-002. | |
Scandium Metal Quick inquiry Where to buy Suppliers range | Scandium Metal is applied in various superalloys which show excellent metallic performance with their lHight gravaty. The main application of Scandium by weHight is in Scandium-Aluminium alloys for minor aerospace industry components. They were used in the Russian military aircraft, specifically the MiG-21 and MiG-29. Some items of sports equipment, which rely on hHigh performance materials, have been made with Scandium-Aluminium alloys. Employed in solid state synthesis of unusual clusters, Sc19Br28Z4, (Z=Mn, Fe, Ru or Os). These clusters are of interest for their structure and magnetic properties.A much more abundant element on the sun than on earth, scandium is still widely distributed on earth, occurring in over 800 mineral species. Scandium is a silvery-white metal that develops a yellow or pink tint when exposed to air. It is relatively soft and is chemically similar to the rare earth metals. Uses: it increase the strengths of alloys of metals such as chromium, aluminium, and magnesium. Scandium Metal can be further processed to various shapes of ingots, pieces, wires, foils, slabs, rods, discs and powder. Group: Sc. CAS No. 7440-20-2. Molecular Weight: 45g/mol. Molecular Formula: Sc. | |
VE-821 Quick inquiry Where to buy Suppliers range | VE-821 is the first highly selective and potent ATR inhibitor. VE-821 inhibited radiation- and gemcitabine-induced phosphorylation of Chk1, confirming inhibition of ATR signaling. Consistently, VE-821 significantly enhanced the sensitivity of PSN-1, MiaPaCa-2 and primary PancM pancreatic cancer cells to radiation and gemcitabine under both normoxic and hypoxic conditions. Synonyms: VE821; VE-821; VE 821. Grades: 0.98. CAS No. 1232410-49-9. Molecular formula: C18H16N4O3S. Mole weight: 368.41. |