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| Product | Description | |
|---|---|---|
| MI-2 | MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM. Synonyms: MI-2 ; Menin-MLL inhibitor 2; Menin-MLL Inhibitor. Grades: >98%. CAS No. 1271738-62-5. Molecular formula: C18H25N5S2. Mole weight: 375.55. |  |
| MI-2 (MALT1 inhibitor) | MI-2 (350 mg/kg) is nontoxic to mice. MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor with IC50 of 5.84 μM. Synonyms: MI-2; MI 2; MI2. Grades: >98%. CAS No. 1047953-91-2. Molecular formula: C19H17Cl3N4O3. Mole weight: 455.72. | |
| MALT1 Inhibitor I, MI-2 (ALB-H03200218, 2-Chloro-N-(4-(5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl)phenyl)acetamide) | A cell-permeable chloromethyl amide that inhibits MALT1 proteolytic activity (IC50 = 5.84uM against MALT1 paracaspase domain dimer-catalyzed Ac-LRSR-AMC hydrolysis) in an irreversible manner via covalent interaction, displaying little or no activity against caspase-3, -8, or -9. Due to irreversible binding and effective intracellular accumulation (HBL-1 intracellular [MI-2]t = 2h = 5uM; Medium [MI-2]t = 0 = 0.2uM), MI-2 is at least 250-times more effective than Z-VRPR-FMK in blocking constitutive NF-kappaB activity and c-Rel nuclear translocation in HBL-1 cultures (equal or better blockage by 200nM MI-2 than by 50uM Z-VRPR-FMK). Shown to selectively inhibit MALT1-dependent ABC-DLBCL proliferation, but not the MALT1-independent growths of ABC- (HLY-1 and U2932) or GCB-DLBCL (OCI-Ly1 and OCI-Ly7) cells, both in cultures in vitro (GI50 in 48h = 200, 400, 400, and 500nM, respectively, against HBL-1, OCI-Ly3, OCI-Ly10, and TMD8) and in mice in vivo (65%,, 61%, and 0% suppression, respective Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Menin-MLL Interaction Inhibitor, MI-2-2 (MI22, 4- (4- (5, 5-Dimethyl-4, 5-dihydrothiazol-2-yl) piperazin-1-yl) -6- (2, 2, 2-trifluoroethyl) thieno[2, 3-d]pyrimidine, HCl) | A cell-permeable thienopyrimidine compound that competes against MLL (Mixed Lineage Leukemia) for menin binding (IC50 = 46 and 520nM, respectively, against MBM1 sequence MLL4-15 and MLL4-43 containing both MBM1 & MBM2) by targeting menin MLL-binding pocket with high affinity (KD = 22nM), effectively disrupting cellular menin and MLL-AF9 fusion interaction (by >90% at 12uM in MLL-AF9-expressing HEK293 cells). Shown to inhibit the oncogenic proliferation of four MLL translocation-harboring human leukemia cell lines (by >95% in 12 d at 6uM), but not non-MLL leukemia Kasumi-1 and HAL-01 lines (≤16% inhibition at 12uM), by downregulating MLL target genes expression via simultaneous hematopoietic differentiation induction and killing of non-differentiated population. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MI 2 dihydrochloride | MI 2 dihydrochloride is a Menin-MLL interaction inhibitor. MI-2 can bind menin and block the menin-MLL fusion protein interaction with IC50 value of 0.45 μM. It can selectively inhibit proliferation and induce apoptosis of leukemia cells harboring MLL fusion proteins. Synonyms: MI 2 dihydrochloride; MI2 dihydrochloride; MI-2 dihydrochloride; 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-propylthieno[2,3-d]pyrimidine dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C18H25N5S2.2HCl. Mole weight: 448.48. | |
| 1-Miristoyl-2-linoleoyl Glycerol 3-Phosphocholine | 1-Miristoyl-2-linoleoyl Glycerol 3-Phosphocholine is a glycerophospholipid. Group: Biochemicals. Grades: Highly Purified. CAS No. 92345-33-0. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C40H76NO8P, Molecular Weight: 730.01. US Biological Life Sciences. | Worldwide |
| ABT-100 | ABT-100 is an orally bioavailable farnesyltransferase inhibitor. ABT-100 inhibited proliferation of cells in vitro carrying oncogenic H-Ras (EJ-1 bladder; IC(50) 2.2 nmol/L), Ki-Ras (DLD-1 colon, MDA-MB-231 breast, HCT-116 colon, and MiaPaCa-2 pancreatic; IC(50) range, 3.8-9.2 nmol/L), and wild-type Ras (PC-3 and DU-145; IC(50), 70 and 818 nmol/L, respectively) as well as clonogenic potential. ABT-100 shows 70% to 80% oral bioavailability in mice. ABT-100 regressed EJ-1 tumors (2-12.5 mg/kg/d s.c., every day for 21 days) and showed significant efficacy in DLD-1, LX-1, MiaPaCa-2, or PC-3 tumor-bearing mice (6.25-50 mg/kg/d s.c. once daily or twice daily orally). Group: Inhibitors. Alternative Names: ABT100; ABT 100; ABT-100; A367074; A 367074; A-367074. CAS No. 450839-40-4. Molecular formula: C27H19F3N4O3. Mole weight: 504.46. Appearance: White solid powder. Purity: >98%. IUPACName: (S)-6-(2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imidazol-5-yl)ethoxy)-4'-(trifluoromethoxy)-[1, 1'-biphenyl]-3-carbonitrile. Canonical SMILES: N#CC1=CC (C2=CC=C (OC (F) (F)F)C=C2)=C (OC[C@] (O) (C3=CC=C (C#N)C=C3)C4=CN=CN4C)C=C1. Catalog: ACM450839404. |  |
| ABT-100 | ABT-100 is an orally bioavailable farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity. Synonyms: ABT 100; ABT100; A-367074; A 367074; A367074. Grades: >98%. CAS No. 450839-40-4. Molecular formula: C27H19F3N4O3. Mole weight: 504.47. | |
| ABT-100 | ABT-100 is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation ( IC 50 s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 450839-40-4. Pack Sizes: 5 mg. Product ID: HY-119257. |  |
| ATP (Standard) | ATP (Standard) is the analytical standard of ATP. This product is intended for research and analytical applications. ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation [1] [2]. In Vitro: ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs [3]. ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner [4]. ATP promotes neutrophil chemotaxis in vitro [4]. In Vivo: ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo [4]. ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo [4]. Uses: Scientific research. Group: Natural products. CAS No. 56-65-5. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B2176R. | |
| BR mixture-2 | BR mixture-2. Group: Others. Purity: >99% (all components have a purity over 99%). Appearance: Powder. Storage: -20°C. BR mixture-2; GC; Branched Chain Fatty Acid Methyl Ester Mixtures; lipid mixture; mix; qualitive mixture; quantitive mixture; Matreya, LLC; Matyera; Larodan; lipid products. Cat No: LMIZ-003. |  |
| Diflorasone Diacetate | Diflorasone Diacetate is a salt of diflorasone, which is a corticosteroid used as anti-inflammatory and anti-itching agent in the topical creams. Diflorasone inhibits the production of the inflammatory cytokines Il-6, Il-4, and macrophage inflammatory protein-2 (Mip-2), and alleviates swelling in the ears of toluene-2,4-diisocyaniate-sensitized mice. Uses: Anti-inflammatory agent. Synonyms: Psorcon; Florone E; Maxiflor; Apexicon e. Grades: 99%. CAS No. 33564-31-7. Molecular formula: C26H32F2O7. Mole weight: 494.52. | |
| FAME mixture-2 | FAME mixture-2. Group: Others. Appearance: Liquid. Storage: -20°C. FAME mixture-2; GC; RM-2 Mixture (AOCS); lipid mixture; mix; qualitive mixture; quantitive mixture; Matreya, LLC; Matyera; Larodan; lipid products. Cat No: LMIZ-096. | |
| FA mixture-20 | FA mixture-20. Group: Others. Purity: >99% (all components have a purity over 99%). Appearance: Powder. Storage: -20°C. FA mixture-20; GC; Free Fatty Acid Mixtures; lipid mixture; mix; qualitive mixture; quantitive mixture; Matreya, LLC; Matyera; Larodan; lipid products. Cat No: LMIZ-063. | |
| Green Fluorescent PLGA Microspheres-20 μm | Excitation/Emission: 460/500 nm. Synonyms: Green Fluorescent PLGA nanoparticles. Product ID: MSMN-013. Category: Polymer Microspheres. |  |
| Green Fluorescent PLGA Microspheres-25 μm | Excitation/emission: 460/500 nm. Synonyms: Green Fluorescent PLGA nanoparticles. Product ID: MSMN-014. Category: Polymer Microspheres. | |
| Green Fluorescent PLGA Microspheres-2 μm | Particles made of poly(D,L-lactide-co-glycolide) L/G ratio of 50/50, inherent viscosity of ~0.45 dL/gTo re-constitute: Warm to ambient temperature; Add DI water or buffer to achieve desired concentration; Vortex and sonicate for 5 minutes to ensure particles are well suspended. Synonyms: Green Fluorescent PLGA nanoparticles. Product ID: MSMN-011. Category: Polymer Microspheres. | |
| HIF-1α-IN-2 | HIF-1α-IN-2 is an effective HIF-1α inhibitor with anticancer potencies ( IC 50 s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2 suppresses HIF-1α expression by blocking transcription and protein translation [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2762315-06-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115903. | |
| Lagociclovir | Lagociclovir is a prodrug of 3'-fluoro-2',3'-dideoxyguanosine with high oral bioavailability in humans and potent activity against HBV. Uses: Antiviral agents. Synonyms: MIV-210; MIV 210; MIV210; 3'-FddG; Fddguo; Lagociclovir. Grades: >98%. CAS No. 92562-88-4. Molecular formula: C10H12FN5O3. Mole weight: 269.23. | |
| microRNA-21-IN-1 | microRNA-21-IN-1 (compound A7) is an efficient microRNA inhibitor. microRNA-21-IN-1 has antiproliferative activity against Hela and HCT-116 cells with IC 50 s of 5.5 μM and 2.8 μM respectively, as well as promotes apoptosis of Hela cells. microRNA-21-IN-1 upregulates the expression of microRNA-21 downstream functional targets (PTEN, EGR1 and SLIT2). microRNA-21-IN-1 can be used for researching anticancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2848720-31-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-146411. | |
| microRNA-21-IN-3 | microRNA-21-IN-3 (compound 45) can specifically bind to the precursor of oncogenic and pro-inflammatory microRNA-21 with medium nanomolar affinity, reduce cancer cell proliferation and miR-21 levels, and can be used in antitumor research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2766106-83-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153534. | |
| PCL Microspheres-20 μm | PCL particles are made with poly(?-caprolactone) with a MW of 14,000.To re-constitute:Warm to ambient temperature; Add DI water or buffer to achieve desired concentration; Vortex and sonicate for 5 minutes to ensure particles are well suspended. Synonyms: PCL Nanoparticles. Product ID: MSMN-019. Category: Polymer Microspheres. | |
| PLGA Microspheres-20 μm | Particles made of poly(D,L-lactide-co-glycolide) L/G ratio of 50/50, inherent viscosity of ~0.45 dL/gTo re-constitute: Warm to ambient temperature; Add DI water or buffer to achieve desired concentration; Vortex and sonicate for 5 minutes to ensure particles are well suspended. Synonyms: PLGA Nanoparticles. Product ID: MSMN-005. Category: Polymer Microspheres. | |
| PLGA Microspheres-25 μm | PLGA Microspheres-25 μm. Synonyms: PLGA Nanoparticles. Product ID: MSMN-006. Category: Polymer Microspheres. | |
| PLGA Microspheres-2 μm | To re-constitute: Remove the product from freezer.Wait until temperature rises to the ambient temperature.Add DI water or buffer to the container. Vortex and sonicate for 5 minutes to ensure the microspheres are well suspended. Synonyms: PLGA Nanoparticles. Product ID: MSMN-002. Category: Polymer Microspheres. | |
| Protectin D1 | Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and HIF-1α signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3 , ASC , and Caspase-1 , and consequently decreasing the release of pro-inflammatory cytokines IL-1β and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Neuroprotectin D1; NPD1. CAS No. 660430-03-5. Pack Sizes: 10 μg (138.7 μM * 200 μL in ethanol). Product ID: HY-130413. | |
| TLC non-polar lipid mixture-2 | TLC non-polar lipid mixture-2. Group: Others. Appearance: Liquid. Storage: -20°C. Source: Plant, ovine. TLC non-polar lipid mixture-2; TLC; Non-Polar Lipid Mixture B (quantitative); lipid mixture; mix; qualitive mixture; quantitive mixture; Matreya, LLC; Matyera; Larodan; lipid products. Cat No: LMIZ-104. | |
| VE-821 | VE-821 is the first highly selective and potent ATR inhibitor. VE-821 inhibited radiation- and gemcitabine-induced phosphorylation of Chk1, confirming inhibition of ATR signaling. Consistently, VE-821 significantly enhanced the sensitivity of PSN-1, MiaPaCa-2 and primary PancM pancreatic cancer cells to radiation and gemcitabine under both normoxic and hypoxic conditions. Synonyms: VE821; VE-821; VE 821. Grades: 0.98. CAS No. 1232410-49-9. Molecular formula: C18H16N4O3S. Mole weight: 368.41. | |
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