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| Product | Description | |
|---|---|---|
| Mitochonic acid 5 | Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage. Mitochonic acid 5 modulates mitochondrial ATP synthesis. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MA-5. CAS No. 1354707-41-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111536. |  |
| Mitochonic Acid 5 | Mitochonic Acid 5 is a derivative of the plant hormone indole-3-acetic acid. It has been shown to improve survival of fibroblasts from patients with mitochondrial diseases. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Mitochonic Acid 5; MA-5; MA 5; MA5. Product Category: Others. Appearance: Solid powder. CAS No. 1354707-41-7. Molecular formula: C18H13F2NO3. Mole weight: 329.3. Purity: >98%. IUPACName: 4-(2,4-Difluorophenyl)-2-(1H-indol-3-yl)-4-oxobutanoic acid. Canonical SMILES: O=C(O)C(C1=CNC2=C1C=CC=C2)CC(C3=CC=C(F)C=C3F)=O. Product ID: ACM1354707417. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Mitochonic Acid 5 | Mitochonic Acid 5 is an effective mitochondrial ATP production enhancer. It binds to mitochondria and improves renal tubular and cardiomyocyte damage. Synonyms: Mitochonic Acid 5(MA-5); SCHEMBL15747705; MA-5; MA 5; MA5. Grades: 98%. CAS No. 1354707-41-7. Molecular formula: C18H13F2NO3. Mole weight: 329.3. |  |
| 11(Z),14(Z),17(Z)-Eicosatrienoic acid | 11(Z),14(Z),17(Z)-Eicosatrienoic acid is an unsaturated fatty acid that can maintain the continued replication of functional mitochondria in Saccharomyces cerevisiae (KD115) [1]. Uses: Scientific research. Group: Natural products. CAS No. 17046-59-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-108398B. | |
| 12- ( ( ( (9H-Fluoren-9-yl) methoxy) carbonyl) amino) dodecanoic Acid | 12- ( ( ( (9H-Fluoren-9-yl) methoxy) carbonyl) amino) dodecanoic Acid has been used as a reactant for the preparation of pro-apoptotic peptide functionalized gold nanoparticles as a new anti-cancer strategy of damaging mitochondria. Group: Biochemicals. Grades: Highly Purified. CAS No. 128917-74-8. Pack Sizes: 500mg, 1 g. Molecular Formula: C27H35NO4, Molecular Weight: 437.57. US Biological Life Sciences. |  Worldwide |
| 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine | 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine is a phosphatidylethanolamine with lauric acid. Phosphatidylethanolamine is a phospholipid found in all living organisms, particularly in nervous tissue. It serves as a precursor of phosphatidylcholine, and promotes membrane fusion, oxidative phosphorylation, mitochondrial biogenesis, and autophagy. Synonyms: DLEA; DLPE; Dilauroyl phosphatidylethanolamine; PE(12:0/12:0); 1,2-didodecanoyl-sn-glycero-3-phosphoethanolamine. Grades: ≥98%. CAS No. 42436-56-6. Molecular formula: C29H58NO8P. Mole weight: 579.76. | |
| 1,2-Dilinoleoyl-sn-glycerol | 1,2-Dilinoleoyl-sn-glycerol is a diacylglycerol (DAG) with linoleic acid (HY-N0729) (18:2) side chains attached at both the sn-1 and sn-2 positions. It has been found as a component of phosphatidic acid in rat liver mitochondria and in spinach chloroplast membranes. 1,2-Dilinoleoyl-sn-glycerol is upregulated in some pregnant women and has been used as a biomarker to predict later preeclampsia in early pregnancy. Uses: Scientific research. Group: Signaling pathways. CAS No. 24529-89-3. Pack Sizes: 5 mg (16.21 mM * 500 μL in Acetonitrile); 10 mg (16.21 mM * 1 mL in Acetonitrile). Product ID: HY-117168. | |
| 2-Chlorohexadecanoic acid | 2-Chlorohexadecanoic acid, an inflammatory lipid mediator, interferes with protein palmitoylation,induces ER-stress markers, reduced the ER ATP content, and activates transcription and secretion of IL-6 as well as IL-8.2-Chlorohexadecanoic acid disrupts the mitochondrial membrane potential and induces procaspase-3 and PARP cleavage.2-Chlorohexadecanoic acid can across blood-brain barrier (BBB) and compromises ER- and mitochondrial functions in the human brain endothelial cell line hCMEC/D3 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 19117-92-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-131688. | |
| 2-Methylcitric acid | 2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Methylcitric acid. CAS No. 6061-96-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-113371. | |
| (2R)-Octyl-α-hydroxyglutarate | (2R)-Octyl-α-hydroxyglutarate is an octyl ester derivative of (2R)-2-Hydroxyglutaric Acid (H942565), a potential inhibitor of glutamate carboxypeptidase. It is used to examine the contribution of D-2HG to the mitochondrial processes of IDH1-mutated cancer cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 1391194-67-4. Pack Sizes: 1mg, 5mg. Molecular Formula: C13H24O5, Molecular Weight: 260.33. US Biological Life Sciences. | Worldwide |
| [3-(Carboxybenzhydryl)-2 3-[3- (tert-Butyldimethylsilyloxy) prop-1-yl]dimethyl Trideuterio Methyl Ammonium Iodide | [3-(Carboxybenzhydryl)-2 3-[3- (tert-Butyldimethylsilyloxy) prop-1-yl]dimethyl Trideuterio Methyl Ammonium Iodide is an intermediate in the synthesis of 3-Hydroxy-9-hexadecenoyl-L-carnitine-d3 (H825457). 3-Hydroxy-9-hexadecenoyl-L-carnitine-d3 chloride is the labeled analog of 3-Hydroxy-9-hexadecenoyl-L-carnitine chloride (H825455) an analogue of 3- hydroxyhexadecanoyl carnitine Inner Salt (H943005), a derivative of Carnitine, essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthesized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado. Also 3- hydroxyhexadecanoyl carnitine works similar to the endogenous non-toxic molecule L-Carnitine (C184110) whose bioavailablity is improved due to the transport systems in place for Carnitine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C42H65D3INO5Si. US Biological Life Sciences. | Worldwide |
| 3-Chloro-1,4-dihydro-1,4-dioxo-2-naphthalenecarboxylic Acid 4- (4-Chlorophenyl) cyclohexyl Ester | 3-Chloro-1,4-dihydro-1,4-dioxo-2-naphthalenecarboxylic Acid 4- (4-Chlorophenyl) cyclohexyl Ester is an impurity in the synthesis of Atovaquone-d5 (A793502), which is an hydroxynaphthoquinone derivative that inhibits mitochondrial electron transport. Antipneumocystic. Group: Biochemicals. Grades: Highly Purified. CAS No. 215672-88-1. Pack Sizes: 50mg, 250mg. Molecular Formula: C23H18Cl2O4. US Biological Life Sciences. | Worldwide |
| 3-(Difluoromethyl)-1H-pyrazole-4-carboxylic Acid | 3-(Difluoromethyl)-1H-pyrazole-4-carboxylic Acid is an intermediate in synthesizing Sedaxane (S242000), a broad-spectrum seed treatment fungicide used for control of seed- and soil-borne diseases in a broad range of crops. It inhibits fungal respiration by binding to the succinate dehydrogenase complex in the fungal mitochondrium. Group: Biochemicals. Grades: Highly Purified. CAS No. 151734-02-0. Pack Sizes: 2.5g, 5g. Molecular Formula: C6H6F2N2O2. US Biological Life Sciences. | Worldwide |
| 3-Nitropropionic acid (3-NP) | A plant and fungal toxin, 3-nitropropionic acid acts as an irreversible inactivator of succinate dehydrogenase. Selectively inhibits succinic dehydrogenase complex (Complex II) in the mitochondrial electron transport chain. Also shown to cause brain lesions similar to those of Huntington?s disease. Group: Biochemicals. Alternative Names: 3-NP, 3-NPA, 3NPA. Grades: Highly Purified. CAS No. 504-88-1. Pack Sizes: 50mg, 250mg. US Biological Life Sciences. | Worldwide |
| 4-Hydroxynonenal | 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 4-HNE. CAS No. 75899-68-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-113466. | |
| 7-Doxyl Stearic Acid | A spin-labeled fatty acid. The reduction of doxylstearates takes place at the level of the ubiquinone in the respiratory chain in mitochondria in these cells. Group: Biochemicals. Alternative Names: 2-(5-Carboxypentyl)-4,4-dimethyl-2-undecyl-. Grades: Highly Purified. CAS No. 40951-82-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 8-[(6-Amino)hexyl]-amino-ATP - ATTO-665 | 8-[(6-Amino)hexyl]-amino-ATP - ATTO-665 is a fluorescent probe used in live cell imaging to monitor ATP-dependent biological processes. It is commonly used to track mitochondrial function and ATP synthesis in cells. ATTO-665 is also used to detect drug interactions with ATP-binding proteins, such as kinases, in drug discovery research. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-5'-triphosphate, labeled with ATTO 665, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H30N7O13P3- ATTO 665 (free acid). Mole weight: 1225.37 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GTP - ATTO-Rho101 | 8-[(6-Amino)hexyl]-amino-GTP - ATTO-Rho101, an essential fluorescent dye for investigating GTPase activity and binding in biological assays, is an exquisite addition to scientific experimentation. The dye is particularly valuable when coupled with Rho GTPases that yield intriguing insights into important cellular activities such as cytoskeletal rearrangement and cell migration. Moreover, the dye's versatility is a cause for praise as it can be employed to label and visualize subcellular structures, including but not limited to mitochondria. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with ATTO Rho101, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C53H67N10O17P3 (free acid). Mole weight: 1208.39 (free acid). | |
| Acetyl-L-carnitine hydrochloride | Acetyl-L-carnitine (O-Acetyl-L-carnitine) hydrochloride is a blood-brain permeable acetyl ester of the amino acid L-carnitine with anti-apoptotic effects. Acetyl-L-carnitine hydrochloride promotes neuronal survival and mitochondrial activity, attenuates DNA fragmentation and nuclear condensation in cultured neurons and signifcantly decreases histone-DNA release into the cytoplasm. Acetyl-L-carnitine hydrochloride is often used as a dietary supplement, and is promising for research of stress-related psychiatric disorders [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: O-Acetyl-L-carnitine hydrochloride; ALCAR hydrochloride. CAS No. 5080-50-2. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-B0762. | |
| Aldehyde Dehydrogenase 2 from Human, Recombinant | ALDH2 is part of the aldehyde dehydrogenase family of proteins which catalyze the chemical transformation from acetaldehyde to acetic acid. ALDH2 is the second enzyme of the major oxidative pathway of alcohol metabolism. ALDH2 has 2 major liver isoforms: cytosolic and mitochondrial, which differ by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Nearly all Caucasians have 2 major isozymes, whereas roughly 50% of Orientals have only the cytosolic isozyme, omitting the mitochondrial isozyme. The extremely higher rate of acute alcohol intoxication with Orientals compared to Caucasians is due to the fact of the absence of mitochondrial... & having a molecular mass of 54.5 kda. the aldh2 is purified by proprietary chromatographic techniques. Group: Enzymes. Synonyms: ALDM; ALDHI; ALDH-E2; MGC1806; ALDH2; Aldehyde dehydrogenase mitochondrial; ALDH class 2. Purity: Greater than 90.0% as determined by SDS-PAGE. ALDH2. Mole weight: 54.5 kDa. Activity: > 0.14 units/ml. Stability: Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles. Appearance: Sterile Filtered clear solution. Source: E. coli. Species: Human. ALDM; ALDHI; ALDH-E2; MGC1806; ALDH2; Aldehyde dehydrogenase mitochondrial; ALDH class 2. Cat No: NATE-0804. |  |
| Alexidine dihydrochloride | Alexidine dihydrochloride is a potent and selective protein tyrosine phosphatase localized to the mitochondrion 1(PTPMT1) inhibitor with IC50 value of 1.08 μM in vitro. It induces apoptosis in cancer cell lines with ED50 value of 1.8-2.6 μM. It is an alkyl bis(biguanide) antiseptic and has been used in mouthwashes to eliminate plaque forming microorganisms. It binds to lipopolysaccharide and lipoteichoic acid, and inhibits fungal phospholipase B with IC50 value of 250 nM. It stimulates increased insulin secretion by isolated rat pancreatic islets and displays antitcancer properties in FaDu cells. It has antibacterial, antiplaque properties against streptococcus mutans, actinomyces naesludii and actinomyces ciscosus. Synonyms: 2,4,11,13-Tetraazatetradecanediimidamide, N1,N14-bis(2-ethylhexyl)-3,12-diimino-, hydrochloride (1:2); 2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(2-ethylhexyl)-3,12-diimino-, dihydrochloride; Biguanide, 1,1'-hexamethylenebis[5-(2-ethylhexyl)-, dihydrochloride; 1,6-Bis(2-ethylhexylbiguanido)hexane dihydrochloride; Alexidine hydrochloride; Hexamethylenebis(2-ethylhexyl)biguanide dihydrochloride. Grades: >98%. CAS No. 1715-30-6. Molecular formula: C26H58N10Cl2. Mole weight: 581.71. | |
| α-Cyano-4-hydroxycinnamic acid | α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a K i of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: α-Cyano-4-hydroxycinnamate. CAS No. 28166-41-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 250 mg. Product ID: HY-107641. | |
| (+/-)-alpha-Lipoamide | (+/-)-alpha-Lipoamide is a coenzyme, which transfer acetyl and hydrogen in Pyruvate deacylation oxidation process. It may be used in treatment of insulin resistance by stimulating mitochondrial biogenesis. It has shown to have a good therapeutic effect on early diabetic nephropathy when used in combination with Alprostadil. Uses: (+/-)-alpha-lipoamide may be used in treatment of insulin resistance by stimulating mitochondrial biogenesis. it has shown to have a good therapeutic effect on early diabetic nephropathy. Synonyms: Lipoamide; Lipoacin; NSC 90787; NSC-90787; NSC90787; Lipoamide;Thioctamide;Thioctic acid amide;Vitamin N;Alpha-Lipoic acid amide;5-(Dithiolan-3-yl)pentanamide;(±)-α-Lipoamide;DL-Lipoamide;DL-6,8-Thioctamide;1,2-Dithiolane-3-pentanamide. Grades: >98 %. CAS No. 940-69-2. Molecular formula: C8H15NOS2. Mole weight: 205.34. | |
| α-Lipoic acid | α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1. Uses: Designed for use in research and industrial production. Additional or Alternative Names: DL-6-Thioctic acid. Product Category: Inhibitors. Appearance: Yellow powder. CAS No. 1077-28-7. Molecular formula: C8H14O2S2. Mole weight: 206.33. Purity: 0.98. IUPACName: 5-(Dithiolan-3-yl)pentanoic acid. Canonical SMILES: C1CSSC1CCCCC(=O)O. Density: 1.2888 g/cm³. Product ID: ACM1077287-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| α-Lipoic Acid | α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB -dependent HIV-1 LTR activation [1] [2] [3]. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells [4]. α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 [5]. Uses: Scientific research. Group: Natural products. Alternative Names: Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid. CAS No. 1077-28-7. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-N0492. | |
| α-Lipoic Acid sodium | α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB -dependent HIV-1 LTR activation [1] [2] [3]. α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells [4]. α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 [5]. Uses: Scientific research. Group: Natural products. Alternative Names: Thioctic acid sodium; (±)-α-Lipoic acid sodium; DL-α-Lipoic acid sodium. CAS No. 2319-84-8. Pack Sizes: 100 mg; 250 mg. Product ID: HY-N0492A. | |
| α-Lipoic Acid (Standard) | α-Lipoic Acid (Standard) is the analytical standard of α-Lipoic Acid. This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB -dependent HIV-1 LTR activation [1] [2] [3]. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells [4]. α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 [5]. Uses: Scientific research. Group: Natural products. Alternative Names: Thioctic acid (Standard); (±)-α-Lipoic acid (Standard); DL-α-Lipoic acid (Standard). CAS No. 1077-28-7. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0492R. | |
| AMPK activator | AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, which coordinates metabolic pathways and thus balances nutrient supply with energy demand. D942 is thought to activate AMPK by inhibiting mitochondrial complex I, producing an increase in AMP levels. AMPK activator stimulates glucose uptake in L6 myocytes and promotes phosphorylation of acetyl-CoA carboxylase, which shown to enhance glucose uptake in L6 myocytes (EC50 = 11.7 μM). Reduces blood glucose levels in ZDF rats in vivo (oral dose 30-100 mg/kg). Because of the favorable physiological outcomes of AMPK activation on metabolism, AMPK has been considered to be an important therapeutic target for controlling human diseases including metabolic syndrome and cancer. Synonyms: D942; AMPK activator; 5-[3-[4-[2- (4-Fluorophenyl) ethoxy]phenyl]propyl]furan-2-carboxylic Acid. Grades: ≥95%. CAS No. 849727-81-7. Molecular formula: C22H21FO4. Mole weight: 368.4. | |
| Ant-ATP | Ant-ATP is a key reagent in the biomedicine industry used for the detection and measurement of ATP levels. It is particularly effective in studying the mechanisms of diseases associated with mitochondrial dysfunction, such as Parkinson's disease. Ant-ATP can also be used to screen potential drugs that target ATP production, making it a valuable tool in drug discovery and development. Synonyms: 2'/3'-O-Anthraniloyl-adenosine-5'-triphosphate, Triethylammonium salt. Grades: ≥ 95% by HPLC. CAS No. 289633-56-3. Molecular formula: C17H21N6O14P3 (free acid). Mole weight: 626.30 (free acid). | |
| ApCpp (Nic) | ApCpp (Nic) is a cutting-edge biomedical compound fostering a pivotal role in bolstering cellular energy compoundion. apCpp (Nic) is acutely augments mitochondrial function. Synonyms: P1-(5'-Adenosyl) P3-[5'-(1-β D-ribofuranosyl-nicotinamide)] [(α,β)-methyleno]triphosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C22H30N7O16P3 (free acid). Mole weight: 741.43 (free acid). | |
| Aspartate Aminotransferase from Human, Recombinant | GOT1 is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, which participate in amino acid metabolism and the urea and tricarboxylic acid cycles. Both enzymes are homodimeric and show close homology.GOT1 Human Recombinant E.coli produced in E.Coli is a single, non-glycosylated polypeptide chain containing 433 amino acids (1-413 a.a.) and having a molecular mass of 48.4 kDa. The GOT1 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. Group: Enzymes. Synonyms: Aspartate transaminase; AST; aspartate aminotransferase; sgot AspAT; ASAT; AAT; serum glutamic oxaloac. Purity: Greater than 95.0% as determined by SDS-PAGE. AST. Activity: > 50 units/mg. Stability: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. Form: Sterile filtered colorless solution. Source: E.coli. Species: Human. Aspartate transaminase; AST; aspartate aminotransferase; sgot AspAT; ASAT; AAT; serum glutamic oxaloacetic transaminase; SGOT; pyridoxal phosphate PLP-dependent transaminase enzyme; EC 2.6.1.1; 9000-97-9; Aspartate aminotransferase 1; Transaminase A; GIG18. Cat No: DIA-128. | |
| Atractyloside, Calcium Salt | Atractyloside Calcium Salt is a specific inhibitor of the adenine nucleotide translocase (ANT), which is a mitochondrial ADP/ATP carrier. It is also a proapoptotic ligand of ANT that induces pore formation by ANT, and results in permeabilization of the mitochondria membrane. Studies on rat hearts suggest that Atractyloside inhibits chloride channels from the mitochondrial membrane. It is used to probe the source of procaspase 8 in human fibroblasts and mouse clonal striatal cells, as related to death receptor-mediated apoptosis. Atractyloside induces the release of ahyaluronidase-induced murine WW domain-containing oxidoreductase from cultured COS-7 cells, with respect to tumor necrosis factor cytotoxicity. Group: Biochemicals. Alternative Names: (2 β,15α)-15-Hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo- β-D-glucopyranosyl]oxy]-19-Norkaur-16-en-18-oic Acid Calcium Salt; 19-Norkaur-16-en-18-oic acid deriv. 1H-2,10a-Ethanophenanthrene Calcium Salt. Grades: Highly Purified. CAS No. 772298-35-8 free acid. Pack Sizes: 500ug, 1mg. US Biological Life Sciences. | Worldwide |
| Betulinic Acid | Betulinic Acid is a natural pentacyclic triterpenoid. Betulinic Acid displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity. Group: Biochemicals. Alternative Names: Mairin; (+)-Betulinic acid; 3 β-Hydroxylup-20(29)-en-28-oic Acid; Betulic Acid; Lupatic Acid; NSC 113090; β-Betulinic Acid; (3 β)-3-HydroxyLup-20(29)-en-28-oic Acid. Grades: Highly Purified. CAS No. 472-15-1. Pack Sizes: 100mg, 250mg, 500mg. Molecular Formula: C??H??O?, Molecular Weight: 456.7. US Biological Life Sciences. | Worldwide |
| Bongkrekic acid | Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans [1]. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 11076-19-0. Pack Sizes: 100 μg (2.06 mM in 100 μL Tris); 500 μg (2.06 mM in 500 μL Tris). Product ID: HY-136406. | |
| CB-839 | CB-839 an is orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. Upon oral administration, CB-839 selectively and irreversibly inhibits glutaminase, a mitochondrial enzyme that is essential for the conversion of the amino acid glutamine into glutamate. By blocking glutamine utilization, proliferation in rapidly growing cells is impaired. Glutamine-dependent tumors rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). ( ). Synonyms: CB-839; CB839; CB 839. Grades: 98%. CAS No. 1439399-58-2. Molecular formula: C26H24F3N7O3S. Mole weight: 571.57. | |
| Ceramide 3 | C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer(t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer(t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer(t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: N-Stearoyl phytosphingosine. CAS No. 34354-88-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-141582. | |
| Chicoric acid | Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Cichoric acid; Dicaffeoyltartaric acid. CAS No. 6537-80-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0457. | |
| Chlorin E6 | Chlorin e6 is a photosensitizer. Chlorin e6 has significantly high photosensitizing activity when present in insulin-containing conjugates and thus able to be internalized by receptor-expressing cells. Chlorin E6 effects viability and mitochondrial activity of Leishmania major and Leishmania braziliensis promastigotes. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (2S-trans)-18-Carboxy-20-(carboxymethyl)-13-ethyl-2,3-dihydro-3,7,12,17-tetramethyl-8-vinyl-21H,23H-porphine-2-propionic acid; (17S,18S)-18-(2-Carboxyethyl)-20-(carboxymethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18,22,23-tetrahydroporphyrin-2-carboxylic acid. Product Category: Inhibitors. Appearance: Purple solid. CAS No. 19660-77-6. Molecular formula: C34H36N4O6. Mole weight: 596.67. Purity: 0.9. Canonical SMILES: OC(C/C1=C2[C@H]([C@@H](C(/C=C3N/C(C(C=C)=C\3C)=C\C4=N/C(C(CC)=C4C)=C\C5=C(C)C(C(O)=O)=C1N5)=N\2)C)CCC(O)=O)=O. Product ID: ACM19660776-2. Alfa Chemistry ISO 9001:2015 Certified. Categories: Chlorine. | |
| cholestanetriol 26-monooxygenase | This mitochondrial cytochrome P-450 enzyme requires adrenodoxin. It catalyses the first three sterol side chain oxidations in bile acid biosynthesis via the neutral (classic) pathway. Can also act on cholesterol, cholest-5-ene-3β,7α-diol, 7α-hydroxycholest-4-en-3-one, and 5β-cholestane-3α,7α-diol. The enzyme can also hydroxylate cholesterol at positions 24 and 25. The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6, adrenodoxin-NADP+ reductase. Group: Enzymes. Synonyms: 5β-cholestane-3α,7α,12α-triol 26-hydroxylase; 5β-cholestane-3α,7α,12α-triol hydroxylase; cholestanetriol 26-hydroxylase; sterol 27-hydroxylase; sterol 26-hydroxylase; cholesterol 27-hydroxyla. Enzyme Commission Number: EC 1.14.15.15. CAS No. 52227-77-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0940; cholestanetriol 26-monooxygenase; EC 1.14.15.15; 52227-77-7; 5β-cholestane-3α,7α,12α-triol 26-hydroxylase; 5β-cholestane-3α,7α,12α-triol hydroxylase; cholestanetriol 26-hydroxylase; sterol 27-hydroxylase; sterol 26-hydroxylase; cholesterol 27-hydroxylase; CYP27A; CYP27A1; cytochrome P450 27A1'. Cat No: EXWM-0940. | |
| Citrate synthase | Citrate synthase is responsible for catalyzing the first reaction of the citric acid cycle: the condensation of acetyl-CoA and oxaloacetate to form citrate. Citrate synthase is localized within eukaryotic cells in the mitochondrial matrix [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9027-96-7. Pack Sizes: 250 U; 500 U; 1000 U. Product ID: HY-P2739. | |
| Creatine Kinase MB Isoenzyme Type-1 from Human, Recombinant | The three isoenzymes (MM, MB, and BB) are found in muscle, cardiac and brain tissues. These recombinant proteins are ideal for calibrating diagnostic instruments and researching neuromuscular diseases. Creatine Kinases can be used for indications in many neuromuscular applications. These disorders include cardiac disease, mitochondrial disorders, inflammatory myopathies, myasthenia, polymyositis, McArdle's disease, NMJ disorders, muscular dystrophy, ALS, hypo and hyperthyroid disorders, central core disease, acid maltase deficiency, myoglobinuria, rhabdomyolysis, motor neuron diseases, rheumatic diseases, and other that create elevated or reduced levels of Creat... in elisa. the ckmbiti is purified by proprietary chromatographic techniques. Group: Enzymes. Synonyms: Creatine Kinase MB Isoenzyme Type-I; Creatine Kinase MB Isoenzyme Type-1; CKMBITI; CKMBI; CKMB; CKMBT1. Purity: Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. CK. Activity: 500 IU/mg. Stability: CKMBITI although stable at 15°C for 7 days, should be stored below -18°C. Please prevent freeze-thaw cycles. Appearance: Sterile Filtered colourless liquid formulation. Source: Pichia Pastoris. Species: Human. Creatine Kinase MB Isoenzyme Type-I; Creatine Kinase MB Isoenzyme Type-1; CKMBITI; CKMBI; CKMB; CKMBT1. Cat No: NATE-0818. | |
| D-Carnitine | D-Carnitine is an orally available isomer of the essential nutrient L-carnitine that promotes long-chain fatty acid transport into the mitochondrial matrix for beta-oxidation. D-Carnitine has antiparasitic activity [1] [2] [3]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 541-14-0. Pack Sizes: 250 mg; 1 g. Product ID: HY-W012550. | |
| D-Carnitine | Essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado. Group: Biochemicals. Alternative Names: (2S)-3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium Inner Salt; D- (3-Carboxy-2-hydroxypropyl) trimethyl Ammonium Hydroxide Inner Salt; (+)-Carnitine; (+)-D-Carnitine; D-(+)-Carnitine; d-Carnitine. Grades: Highly Purified. CAS No. 541-14-0. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| Devimistat | Devimistat (CPI-613) is a mitochondrial metabolism inhibitor. Devimistat is a lipoic acid antagonist that abrogates mitochondrial energy metabolism to induce apoptosis in various cancer cells [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CPI-613. CAS No. 95809-78-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15453. | |
| Diatrizoic acid | Diatrizoic acid (Diatrizoate) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Diatrizoic acid induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Diatrizoate; Amidotrizoic acid. CAS No. 117-96-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-B0926. | |
| Diethyl succinate | Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species ( ROS ), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Diethyl Butanedioate. CAS No. 123-25-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg. Product ID: HY-Y0836. | |
| DS16570511 | DS16570511 is an inhibitor of the mitochondrial calcium uniporter, which blocks the MCU- or MICU1-dependent increase of Ca2+ influx. It inhibits calcium uptake by mitochondria isolated from HEK293A cells, rat heart, and pig heart (IC50s = 0.86, 25, and 15 μM, respectively). Synonyms: 4-(3-(3-(((3-(2,6-dichlorophenyl)-5-methylisoxazol-4-yl)methyl)amino)benzoyl)-1H-indol-1-yl)butanoic acid. Grades: ≥95%. Molecular formula: C30H25Cl2N3O4. Mole weight: 562.44. | |
| Ethyl 3,4-dihydroxybenzoate | Ethyl 3,4-dihydroxybenzoate (Ethyl protocatechuate), an antioxidant, is a prolyl-hydroxylase inhibitor found in the testa of peanut seeds. Ethyl 3,4-dihydroxybenzoate protects myocardium by activating NO synthase and generating mitochondrial ROS. Ethyl 3,4-dihydroxybenzoate induces cell autophagy and apoptosis in ESCC cells. Ethyl 3,4-dihydroxybenzoate is a collagen synthesis inhibitor and has a bone protecting-effect [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Protocatechuic acid ethyl ester. CAS No. 3943-89-3. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-W016409. | |
| Etiroxate Carboxylic Acid | Thyroxin derivative inhibiting glutamate dehydrogenase, isocitrate dehydrogenase, alcohol dehydrogenase, rat liver mitochondrial phosphorylation and electron transfer. Administration also induces hypothyroid state. Group: Biochemicals. Alternative Names: O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-α-methyl-tyrosine; α-Methyl-DL-thyroxine. Grades: Highly Purified. CAS No. 3414-34-4. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Feprazone | Feprazone (DA2370; Prenazone), an analogue of Phenylbutazone (HY-B0230), is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic activities. Feprazone acts by inhibiting the activity of cyclooxygenase (COX)-2. Feprazone ameliorates free fatty acid (FFA)-induced oxidative stress by reducing the production of mitochondrial reactive oxygen species (ROS). Feprazone can decrease the expression of MMP-2 and MMP-9. Besides, Feprazone can suppress adipogenesis and increase lipolysis in differentiating 3 T3-L1 cells. Feprazone also can be used to research atherosclerosis and obesity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DA2370; Prenazone; Zepelin. CAS No. 30748-29-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-114911. | |
| Fmoc-β-alanine pentafluorophenyl ester | Fmoc-β-alanine pentafluorophenyl ester is a Fmoc protected alanine derivative. Also, it is a reagent used in the synthesis of benzophenone-peptide nucleic acid derivative for mitochondrial targeting. Synonyms: Fmoc-β-Ala-OPfp; FMOC-BETA-ALA-OPFP; AK170195; Fmoc-b-Ala-OPfp; Fmoc-I(2)-Ala-OPfp; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-β-alanine-pentafluorophenylester; (2,3,4,5,6-pentafluorophenyl) 3-(9H-fluoren-9-ylmethoxycarbonylamino)propanoate; FMOC BETA ALA OPFP. Grades: ≥ 99% (HPLC). CAS No. 149303-38-8. Molecular formula: C24H16F5NO4. Mole weight: 477.40. | |
| Formyl-L-methionine | Formyl-L-methionine is a protein amino acid present in the organelles of bacteria and related eukaryotes. It is a derivative of the amino acid methionine, in which a formate is added to the amino group of the methionine. It plays a crucial role in protein biosynthesis in bacteria, Mitochondria and chloroplasts. But it is not used for protein biosynthesis in Eukaryotic Cytosol, in which only the nuclear genes are translated. It's also not used in ARCHAEA. In humans, it is recognized by the immune system as a foreign substance and stimulates the body to fight potential infections. Synonyms: For-L-Met-OH; N-Formyl-L-methionine; 2-formamido-4-methylsulfanylbutanoic acid; N-Formyl-L -Methionine; L-Methionine, N-formyl-;(S)-2-Formamido-4-(methylthio)butanoic acid. Grades: ≥ 98% (HPLC). CAS No. 4289-98-9. Molecular formula: C6H11NO3S. Mole weight: 177.22. | |
| Fumarate Hydratase from Human, Recombinant | Fumarase catalyzes the reversible hydration of fumarate to malate. In its mitochondrial form, fumarate is involved in the Krebs Cycle, while the cytosolic form is involved in amino acid metabolism. Group: Enzymes. Synonyms: EC 4. 2. 1. 2; fumarase; L-malate hydro-lyase; (S)-malate hydro-lyase; 9032-88-6; MCL; LRCC; HLRCC; MCUL1; FH. Enzyme Commission Number: EC 4. 2. 1. 2. Purity: >95% by SDS-PAGE analysis. Mole weight: 50.2 kDa. Activity: >25 unit/mg. Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. Form: Sterile filtered colorless solution. Source: E. coli. Species: Human. EC 4. 2. 1. 2; fumarase; L-malate hydro-lyase; (S)-malate hydro-lyase; 9032-88-6; MCL; LRCC; HLRCC; MCUL1; FH; Fumarate hydratase. Cat No: NATE-1777. | |
| Glutaryl-L-Carnitine, Lithium Salt | A metabolite of L-Carnitine. Increased formation and excretion of glutarylcarnitin results from a glutaryl-CoA dehydrogenase deficiency, an inborn error of lysine and tryptophan metabolism. Secondary carnitine depletion due to increased formation and urinary excretion of glutarylcarnitine is suggested to play an important role in the neuropathogenesis of glutaryl-CoA dehydrogenase deficiency, inducing excitotoxic neuronal damage and mitochondrial dysfunction. Group: Biochemicals. Alternative Names: (2R)-3-Carboxy-2-(4-carboxy-1-oxobutoxy)-N,N,N-trimethyl-1-propanaminium inner salt; Glutarylcarnitine; L-Carnitine lithium glutarate. Grades: Highly Purified. CAS No. 102636-82-8 (free acid). Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Glutathione S-Transferase from E.coli, Recombinant | Glutathione S-transferases (GSTs), previously known as ligandins, comprise a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification. The GST family consists of three superfamilies:the cytosolic, mitochondrial, and microsomal--also known as MAPEG--proteins. Members of the GST superfamily are extremely diverse in amino acid sequence, and a large fraction of the sequences deposited in public databases are of unknown function. The Enzyme Function Initiative (EFI) is using GSTs as a model superfamily to iden...ferase. Mole weight: 26kDa. Activity: >20 units/mg. Stability: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. Form: Sterile Filtered clear solution in Phosphate Buffered Saline pH 7.4. Source: E.coli. Species: E.coli. Glutathione S-transferases; GSTs; GST; Glutathione S-alkenetransferase; Glutathione S-alkyltransferase; Glutathione S-aralkyltransferase; Glutathione S-aryltransferase; Glutathione S-epoxidetransferase; RX:Glutathione R-transferase; EC 2.5.1.18; 50812-37-8. Cat No: NATE-1945. | |
| Glutathione S-Transferase, Recombinant | Glutathione S-transferases (GSTs), previously known as ligandins, comprise a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification. The GST family consists of three superfamilies:the cytosolic, mitochondrial, and microsomalalso known as MAPEGproteins. Members of the GST superfamily are extremely diverse in amino acid sequence, and a large fraction of the sequences deposited in public databases are of unknown function. The Enzyme Function Initiative (EFI) is using GSTs as a model superfamily to identify new...erase; Glutathione S-aryltransferase; Glutathione S-epoxidetransferase; RX:Glutathione R-transferase; EC 2.5.1.18; 50812-37-8. Enzyme Commission Number: EC 2.5.1.18. Purity: >90% (SDS-PAGE test). Mole weight: About 26kDa (SDS-PAGE detection). Activity: 30 u/mg. Appearance: White powder, lyophilized or colorless liquid. Storage: 4°C, store at -20°C for long-term preservation. Form: Freeze dried powder. Glutathione S-transferases; GSTs; GST; Glutathione S-alkenetransferase; Glutathione S-alkyltransferase; Glutathione S-aralkyltransferase; Glutathione S-aryltransferase; Glutathione S-epoxidetransferase; RX:Glutathione R-transferase; EC 2.5.1.18; 50812-37-8. Cat No: NATE-1141. | |
| Glyphosate | Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is an herbicidal derivative of the amino acid glycine. Glyphosate inhibits the enzymatic activity of the 5-endopyruvylshikimate 3-phosphate synthase (EPSPS) in the shikimic acid pathway, preventing the synthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan. Glyphosate induces oxidative stress, neuroinflammation, and mitochondrial dysfunction, processes that lead to neuronal death by autophagia , necrosis , or apoptosis , as well as the appearance of behavioral and motor disorders [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 1071-83-6. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-B0863. | |
| GO-203 TFA | GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 1222186-26-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1925A. | |
| GT1b-Ganglioside (triammonium salt) | GT1b-Ganglioside is demonstrated to protect mouse brain cells against L-cysteine-induced damage of mitochondrial DNA and increased lipid peroxidation, suggested to operate through scavenging of OH radicals promoted by L-cysteine. GT1b-Ganglioside is also demonstrated to suppress seizures, damage to mitochondrial DNA and lipid peroxidation induced by kainic acid. Synonyms: Trisialoganglioside-GT1b (porcine brain, triammonium salt). Grades: >99%. CAS No. 59247-13-1. Molecular formula: C95H174N8O47. Mole weight: 2180.42. | |
| GW 7647 | GW 7647 is a potent and highly selective PPARα agonist (EC50 = 6, 1100 and 6200 nM for human PPARα, PPARγ and PPARδ receptors, respectively) with 200-fold selectivity over PPARγ and PPAR&delta. GW 7647 modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubules in vitro via activating PPAR&alpha. GW 7647 exhibits lipid-lowering and anti-inflammatory effects. Synonyms: GW-7647; GW 7647; GW7647. 2-[[4-[2-[[ (Cyclohexylamino) carbonyl] (4-cyclohexylbutyl) amino]ethyl]phenyl]thio]-2-methylpropanoic acid. Grades: ≥99% by HPLC. CAS No. 265129-71-3. Molecular formula: C29H46N2O3S. Mole weight: 502.75. | |
| HCV371 | HCV371 is a potent and selective HCV NS5B polymerase inhibitor. It binds the NS5B with an apparent dissociation constant of 150 nM, which leads to high selectivity and lack of cytotoxicity in the antiviral assays. It displayed broad inhibitory activities against the NS5B RdRp enzyme. It showed no inhibitory activity against a panel of human polymerases, including mitochondrial DNA polymerase gamma and other unrelated viral polymerases. Synonyms: HCV-371; HCV 371; HCV371. (R)-2-(5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid. Grades: 98%. CAS No. 675184-27-7. Molecular formula: C18H20N2O3. Mole weight: 312.37. | |
| HIF-PHD Inhibitor II, JNJ-42041935 (HIF Prolyl Hydroxylase Inhibitor II, 1-(5-Chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic Acid) | A cell-permeable benzimidazolopyrazole compound that acts as an active-site binding, iron insensitive, 2-oxoglutarate competitive, reversible and potent inhibitor of PHD1, 2 and 3 isozymes (pKi=7.91, 7.29 and 7.65, respectively). Displays >100-fold selectivity over FIH (factor inhibiting hydroxylase; pIC50 ~4) and minimal affinity towards a panel of receptors, enzymes and kinases. Shown to elevate HIF-1a levels in Hep3B cells and stimulate erythropoietin secretion in mice, and reverse inflammation-induced anemia in rats (100uM/kg). Shown to inhibit malate dehydrogenase 2 (MDH2) activity and suppress mitochondrial respiration. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H?ClF?N?O?, Molecular Weight: 346.7. US Biological Life Sciences. | Worldwide |
| Humanin | Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging [1] [2]. Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG [2]. Uses: Scientific research. Group: Peptides. CAS No. 330936-69-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P1928. | |
| Idebenone | Idebenone, a well-appreciated mitochondrial protectant, exhibits protective efficacy against neurotoxicity and can be used for the research of Alzheimer's disease, Huntington's disease. Idebenone (oxidised form) has a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid in astroglial homogenates (IC 50 =16.65 μM) [1]. Idebenone, a coenzyme Q10 analog and an antioxidant, induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells [2]. Idebenone quickly crosses the blood-brain barrier. Uses: Scientific research. Group: Signaling pathways. CAS No. 58186-27-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0303. | |
| intermediate cleaving peptidase 55 | Icp55 removes the destabilizing N-terminal amino acid residues that are left after cleavage by the mitochondrial processing peptidase, leading to the stabilisation of the substrate. The enzyme can remove single amino acids or a short peptide, as in the case of cysteine desulfurase (EC 2.8.1.7), where three amino acids are removed. Group: Enzymes. Synonyms: Icp55; mitochondrial intermediate cleaving peptidase 55 kDa. Enzyme Commission Number: EC 3.4.11.26. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4023; intermediate cleaving peptidase 55; EC 3.4.11.26; Icp55; mitochondrial intermediate cleaving peptidase 55 kDa. Cat No: EXWM-4023. | |
| L-2-Hydroxyglutaric acid | L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation [1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase ( Mi-CK ) activity with K m and K i of 2.52 mM and 11.13 mM, respectively [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (S)-2-Hydroxyglutaric acid. CAS No. 13095-48-2. Pack Sizes: 5 mg (67.52 mM * 0.5 mL in Ethanol); 10 mg (67.52 mM * 1 mL in Ethanol). Product ID: HY-113039. | |
| L-2-Hydroxyglutaric acid disodium | L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation [1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase ( Mi-CK ) activity with K m and K i of 2.52 mM and 11.13 mM, respectively [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (S)-2-Hydroxyglutaric acid disodium. CAS No. 63512-50-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-W015114. | |
| L-Carnitine | L-carnitine is a constituent striated muscle and liver, and also a cofactor involved in fatty acid metabolism for transporting fatty acids through the inner mitochondrial membrane. It also acts as an inhibitor of HDAC. Nutritional supplement in health care products. Uses: Ingredient of health care products. Synonyms: Levocarnitine; Vitamin BT; (R)-Carnitine; Carnitor; ST-198; ST 198; ST198; (3R)-3-hydroxy-4-(trimethylazaniumyl)butanoate. Grades: 98%. CAS No. 541-15-1. Molecular formula: C7H15NO3. Mole weight: 161.201. | |
| L-Carnitine-13C Chloride | L-Carnitine-13C Chloride is an essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Applications: An essential cofactor of fatty acid metabolism. Group: Coenzymes. Synonyms: AG-B-72503. CAS No. 541-15-1 (unlabeled). Mole weight: 198.65. AG-B-72503; L-Carnitine-13C Chloride; 541-15-1 (unlabeled). Cat No: COEC-092. | |
| L-Carnitine 97+% | Essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado. Group: Biochemicals. Alternative Names: (2R)-3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium Inner Salt; L- (3-Carboxy-2-hydroxypropyl) trimethyl Ammonium Hydroxide Inner Salt; (-)-Carnitine; (-)-L-Carnitine; (R)-Carnitine; Levocarnitine; Natrulon RC; ST 198; Vitamin BT. Grades: Highly Purified. CAS No. 541-15-1. Pack Sizes: 100g, 250g, 500g, 1Kg. Molecular Formula: C?H??NO?, Molecular Weight: 161.2. US Biological Life Sciences. | Worldwide |
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