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| Product | Description | |
|---|---|---|
| mitogen-activated protein kinase kinase | This enzyme is a dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation. It is required for activation of EC 2.7.11.24, mitogen-activated protein kinase. Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues. Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury. Group: Enzymes. Synonyms: MAP kinase kinase; MAP kinase kinase 4; MAP kinase kinase 7; MAP kinase or ERK . Enzyme Commission Number: EC 2.7.12.2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3162; mitogen-activated protein kinase kinase; EC 2.7.12.2; MAP kinase kinase; MAP kinase kinase 4; MAP kinase kinase 7; MAP kinase or ERK kinase; MAP2K; MAPKK; MAPKK1; MEK; MEK1; MEK2; MKK; MKK2; MKK4; MKK6; MKK7; STK27. Cat No: EXWM-3162. |  |
| mitogen-activated protein kinase kinase kinase | This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) but requires MAPKKKK for activation. Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras. While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway. Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e...mes. Synonyms: cMos; cRaf; MAPKKK; MAP3K; MAP kinase kinase kinase; MEKK; MEKK1; MEKK2; MEKK3; MEK kinase; Mil/Raf; MLK-like mitogen-activated protein triple kinase; MLTK; MLTKa; MLTKb; REKS; STK28. Enzyme Commission Number: EC 2.7.11.25. CAS No. 146702-84-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3145; mitogen-activated protein kinase kinase kinase; EC 2.7.11.25; 146702-84-3; cMos; cRaf; MAPKKK; MAP3K; MAP kinase kinase kinase; MEKK; MEKK1; MEKK2; MEKK3; MEK kinase; Mil/Raf; MLK-like mitogen-activated protein triple kinase; MLTK; MLTKa; MLTKb; REKS; STK28. Cat No: EXWM-3145. | |
| mitogen-activated protein kinase | Phosphorylation of specific tyrosineand threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline. A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth...pk; PMK-1; PMK-2; PMK-3; pp42; pp44mapk; p44mpk; SAPK; STK26; stress-activated protein kinase. Enzyme Commission Number: EC 2.7.11.24. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3144; mitogen-activated protein kinase; EC 2.7.11.24; c-Jun N-terminal kinase; Dp38; ERK; ERK1; ERK2; extracellular signal-regulated kinase; JNK; JNK3α1; LeMPK3; MAP kinase; MAP-2 kinase; MAPK; MBP kinase I; MBP kinase II; microtubule-associated protein 2 kinase; microtubule-associated protein kinase; myelin basic protein kinase; p38Δ; p38-2; p42 mitogen-activated protein kinase; p42mapk; PMK-1; PMK- | |
| MNK1/2 Inhibitor II, ETP-45835 (ETP45835?MNK Inhibitor II, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor II) (4-(3-(Piperidin-4-yl)-1H-pyrazol-5-yl)pyridine, diHCl) | A cell-permeable 3,5-disubstituted pyrazolo compound that acts as a selective MNK inhibitor (IC50=646 and 575nM, respectively, against MNK1 and MNK2) with much reduced or little activity against 24 other kinases (<15% inhibition at 5uM). Reported to exhibit good aqueous solubility (>100uM at pH 7.4) and inhibit the proliferation (IC50=17uM) and cellular eIF4E Ser209 phosphorylation (IC50=4.7uM) of MV4:11 cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N? 2HCl. US Biological Life Sciences. |  Worldwide |
| 10Z-Hymenialdisine | Insecticidal and cytotoxic. Potent NF-kappaB inhibitor. Inhibits various pro-inflammatory cytokines such as IL-1, IL-2, IL-6, IL-8, TNF-alpha and nitric oxide (NO) in a variety of cell lines. ATP-competitive kinase inhibitor. Inhibits DNA damage checkpoint at G2, cyclin-dependent kinases CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, CDK5/p25, GSK-3beta and casein kinase 1 (CK1). Potent mitogen-activated protein kinase kinase-1 (MEK-1) inhibitor. MARK (microtubule affinity-regulating kinase) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 82005-12-7. Pack Sizes: 500ug, 1mg. Molecular Formula: C??H??BrN?O?, Method for Determining. US Biological Life Sciences. | Worldwide |
| 10Z-Hymenialdisine (Hymenialdisine, 4-(2-Amino-4-oxo-2-imidazolidin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one) | Isolated from sponge Axinella carteri. A potent inhibitor of mitogen-activated protein kinase kinase-1 (MEK-1) (IC50=6nm). Blocks the in vivo phosphorylation of the microtubule-binding protein tau at sites that are hyperphosphorylated by glycogen synthase kinase-b (GSK-3b) and CDK5/p35 in Alzheimers disease. Inhibitor of DNA damage checkpoint at G2 phase (IC50=6uM), cyclin-dependent kinases CDK1/cyclin B (IC50=22nm), CDK2/cyclin A (IC50=70 nm), CDK2/cyclin E (IC50=40nm), CDK4/cyclin D1 (IC50 = 600nm), CDK5/p25 (IC50=28nm), GSK-3b (IC50=10nm), and casein kinase 1 (CK1) (IC50=35nm). Group: Biochemicals. Grades: Highly Purified. CAS No. 82005-12-7. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
| 2-(2-Chloropyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one | 2-(2-Chloropyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one is used to prepare pyrrolopyridine Inhibitors of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK-2). It is also used to synthesize heteroaryl-substituted pyrrolopyridinones and analogs as cdc7 kinase inhibitors and potential antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 724726-05-0. Pack Sizes: 5mg, 10mg. Molecular Formula: C12H10ClN3O. US Biological Life Sciences. | Worldwide |
| 2-Bromo-1-(2-chloropyridin-4-yl)ethanone Hydrobromide | 2-Bromo-1-(2-chloropyridin-4-yl)ethanone hydrobromide is a reagent in the synthesis of pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2) (M424495). Group: Biochemicals. Grades: Highly Purified. CAS No. 569667-89-6. Pack Sizes: 100mg, 250mg. Molecular Formula: C7H6Br2ClNO, Molecular Weight: 315.39. US Biological Life Sciences. | Worldwide |
| 2-Fluoro-4-iodoaniline | 2-Fluoro-4-iodoaniline is widely used in the pharmaceutical, chemical and food industries as a fundamental building block to create a variety of important compounds. 2-Fluoro-4-iodoaniline is mostly known as a moiety of TAK-733, a selective inhibitor of mitogen-activated or extracellular signal-regulated protein kinase kinase 2 (MEK2). Group: Biochemicals. Grades: Highly Purified. CAS No. 29632-74-4. Pack Sizes: 25g, 50g. Molecular Formula: C6H5FIN, Molecular Weight: 237.01. US Biological Life Sciences. | Worldwide |
| 3,3-Diethoxypropionitrile | 3,3-Diethoxypropionitrile is a propionitrile derivative used in the preparation of various biologically active compounds such as p38α mitogen-activated protein kinase inhibitors. Group: Biochemicals. Alternative Names: 3, 3-Diethoxypropane nitrile; Cyanoacetaldehyde Diethyl Acetal; Malonaldehydenitrile Diethyl Acetal. Grades: Highly Purified. CAS No. 2032-34-0. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| Acumapimod | Acumapimod is a P38 mitogen-activated protein kinase inhibitor with IC50 value of less than 1 μM for p38α. Phase II clinical trials for the treatment of Chronic obstructive pulmonary disease are on-going. Uses: Chronic obstructive pulmonary disease. Synonyms: BCT-197; BCT197; BCT 197; BCT197A2201; Acumapimod; 3-(5-amino-4-(3-cyanobenzoyl)-1H-pyrazol-1-yl)-N-cyclopropyl-4-methylbenzamide. Grade: 98%. CAS No. 836683-15-9. Molecular formula: C22H19N5O2. Mole weight: 385.42. |  |
| AICAR phosphate | AICAR phosphate, is an AMP-activated protein kinase activator, which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. It stimulates glucose uptake and increases the activity of p38 mitogen-activated protein kinases α and β in skeletal muscle tissue, as well as suppressing apoptosis by reducing production of reactive oxygen compounds inside the cell. Synonyms: Acadesine phosphate; AICA Riboside phosphate. Grade: >98%. CAS No. 681006-28-0. Molecular formula: C9H17N4O9P. Mole weight: 356.23. | |
| Ammocidin | It is produced by the strain of Saccharothrix sp. AJ 9571. It can reduce the phosphorylation level of mitogen-activated protein kinase (MAPK)S6K. It induces apoptosis in Ras Ba/F3-V12 cells with an IC50 of 66 ng/mL, but not in IL-3 Ba/F3-V12 cells with 100 μg/mL. Synonyms: Ammocidin A. Molecular formula: C59H96O21. Mole weight: 1141.38. | |
| Anisomycin (Flagecidin, Antibiotic SA 3097C1, Antibiotic PA 106, Anhydroscopin A, NSC) | Anisomycin is a phenyl methyl enepyrrolidine first isolated from Streptomyces griseolus in 1954 as an antiprotozoan with antifungal activity. Anisomycin acts as an inhibitor of protein synthesis by binding to the 60S ribosomal subunit. Interestingly, anisomycin has found use for the induction of amnesia in animal models. More recently, anisomycin has been demonstrated to induce apoptosis, to be a selective signalling agonist, to activate mitogen-activated protein (MAP) kinases and to be immunomodulatory via its action on T cells. Group: Biochemicals. Alternative Names: ((2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate, 2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate. Grades: Highly Purified. CAS No. 22862-76-6. Pack Sizes: 25mg, 100mg, 250mg. US Biological Life Sciences. | Worldwide |
| anthrax lethal factor endopeptidase | From the bacterium Bacilus anthracis that causes anthrax. One of three proteins that are collectively termed anthrax toxin. Cleaves several MAP kinase kinases near their N-termini, preventing them from phosphorylating the downstream mitogen-activated protein kinases. In peptidase family M34. Group: Enzymes. Synonyms: lethal toxin. Enzyme Commission Number: EC 3.4.24.83. CAS No. 477950-41-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4367; anthrax lethal factor endopeptidase; EC 3.4.24.83; 477950-41-7; lethal toxin. Cat No: EXWM-4367. | |
| Asiaticoside | Antibacterial. Human collagen I synthesis inducer. Anti-wrinkle activity. Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth. Suppresses collagen expression and TGF-beta/Smad signaling by inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII. Anti-inflammatory. Anti-gastric ulcer. Mitogen-activated protein kinases (MAPKs), nuclear factor-kappaB (NF-kappaB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOSII) expression, production of serum tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) inhibitor. Apoptosis inducer in cancer cells. Enhances antitumor activity of vincristine in cancer cells. Might be useful in cancer chemotherapy. Anxiolytic. Antidepressant-like activity. Hepatoprotective effects. CYP2C19 and CYP3A4 inhibitor. Neuroprotective. Antileishmanial activity. cPLA2 and sPLA2 inhibitor. Group: Biochemicals. Alternative Names: Blastostimulina, Centelase, Emdecassol, Madecassol, Marticassol, FK1080, BRN 0078195, NSC 166062. Grades: Highly Purified. CAS No. 16830-15-2. Pack Sizes: 10mg, 50mg. Molecular Formula: C48H78O19. US Biological Life Sciences. | Worldwide |
| AZD-8330 | AZD8330 is an orally active, selective MEK inhibitor with potential antineoplastic activity. AZD8330 specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. Synonyms: AZD8330; AZD-8330; AZD 8330; ARRY424704; ARRY 424704; ARRY-424704; ARRY704; ARRY-704; ARRY 704. Grade: 0.98. CAS No. 869357-68-6. Molecular formula: C16H17FIN3O4. Mole weight: 461.232. | |
| BI-847325 | BI-847325 is an orally available dual inhibitor of mitogen-activated protein kinase kinase (MEK) and Aurora kinases, with potential antineoplastic activity. Upon oral administration, MEK/Aurora kinase inhibitor BI 847325 selectively binds to and inhibits the activity of MEK, which both prevents the activation of MEK-dependent effector proteins and inhibits growth factor-mediated cell signaling. BI 847325 also binds to and inhibits the activity of the Aurora kinases A, B and C which may disrupt the assembly of the mitotic spindle apparatus, prevent chromosome segregation, and inhibit both cellular division and proliferation in Aurora kinase-overexpressing tumor cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BI-847325; BI 847325; BI847325. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1207293-36-4. Molecular formula: C29H28N4O2. Mole weight: 464.57. Purity: >98%. IUPACName: (Z)-3-(3-((4-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide. Canonical SMILES: O=C(NCC)C#CC1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC=CC=C4. Product ID: ACM1207293364-1. Alfa Chemistry ISO 9001:2015 Certified. |  |
| BMS582949 | BMS582949 is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor with IC50 value of 13nM, which plays a crucial role in regulating the biosynthesis of many inflammatory cytokines including TNFα and IL-1β. It is used for the treatment of rheumatoid arthritis. It was developed by Bristol-Myers Squibb and was in clinic phase 2 trials, but now it is terminated. Uses: Bms582949 is used for the treatment of rheumatoid arthritis. Synonyms: 4-[[5-[(Cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide; BMS-582949; PS-540446; BMS 582949; PS 540446; BMS582949; PS540446. Grade: 98%. CAS No. 623152-17-0. Molecular formula: C22H26N6O2. Mole weight: 406.49. | |
| BMS-582949 hydrochloride | BMS-582949 hydrochloride is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor with IC50 of 13 nM. It displays >2000-fold selectivity for p38α over a diverse panel of 57 kinases including serine kinases, nonreceptor tyrosine kinases, receptor tyrosine kinases, and the p38γ and δ isoforms. It is a weak inhibitor of CYP3A4, with an IC50 value ranging from 18 to 40 μM based in multiple tests. It does not significantly inhibit cytochrome P450 isozymes 1A2, 2C9, 2C19, and 2D6 in vitro. It exhibited oral bioavailability values of 90% and 60% in mice and rats, respectively. It is currently under Phase II clinical trials for the treatment of inflammatory diseases. Uses: Bms-582949 hydrochloride is used for the treatment of inflammatory diseases. Synonyms: BMS 582949 hydrochloride; BMS582949 hydrochloride; BMS-582949 hydrochloride; 4-((5-((Cyclopropylamino)carbonyl)-2-methylphenyl)amino)-5-methyl-n-propylpyrrolo(2,1-f)(1,2,4)triazine-6-carboxamide. Grade: >98%. CAS No. 912806-16-7. Molecular formula: C22H27ClN6O2. Mole weight: 442.94. | |
| bpV(phen) | Potent protein phosphotyrosine phosphatase inhibitor Insulin receptor kinase (IRK) inducer. Insulin mimetic in vitro and in vivo. Apoptosis inducer. ERK inducer. Mitogen-activated protein kinase phosphatase-1 (MKP-1) inducer. Angiogenesis inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 171202-16-7. Pack Sizes: 5mg, 25mg. Molecular Formula: K[VO(O2)2C12H8N2]. 3H2O. US Biological Life Sciences. | Worldwide |
| CAY10429-d3 | Abnormal Cannabidiol is a potent and selective GPR55 agonist. It is a synthetic regioisomer of cannabidiol, which unlike most other cannabinoids produces vasodilator effects, lowers blood pressure, and induces cell migration, cell proliferation and mitogen-activated protein kinase activation in microglia, but without producing any psychoactive effects. CAY10429-d3 contains three deuterium atoms at the terminal methyl position. Synonyms: Abn-CBD-d3; Abnormal cannabidiol-d3. Grade: ≥99% atom D. Molecular formula: C21H27D3O2. Mole weight: 317.5. | |
| CMPD-1 | CMPD-1, also called MK2a Inhibitor, inhibits tubulin polymerisation. It inhibit p38α-mediated MK2a phosphorylation (apparent Ki = 330 nM). Synonyms: CMPD1; CMPD-1; CMPD 1; IN1225; IN-1225; IN 1225; 4-[4-(2-fluorophenyl)phenyl]-N-(4-hydroxyphenyl)butanamide; MK2a Inhibitor; MAPKAPK2a Inhibitor; CMPD1; CHEMBL235658; 41179-33-3; IN1225; 4-(2' -Fluorobiphenyl-4-yl)-N-(4-hydroxyphenyl)-butyramide; Mitogen-activated protein kinase-activated protein kinase 2a Inhibitor; MK2a Inhibitor_x000D_; SCHEMBL169905. CAS No. 41179-33-3. Molecular formula: C22H20FNO2. Mole weight: 349.4. | |
| CP654577 | CP654577 is a selective p185(erbB2) kinase inhibitor. It could reduce the levels of the activated form of mitogen-activated protein kinase of SKBr3 human breast cancer cells. Synonyms: CP-654577; CP 654577; 3-Azabicyclo(3.1.0)hexane-6-methanol, 3-((4-(4-((3-methoxy-4-phenoxyphenyl)amino)-6-quinazolinyl)phenyl)methyl)-, (1alpha,5alpha,6alpha)-. Grade: 98%. CAS No. 639087-64-2. Molecular formula: C34H32N4O3. Mole weight: 544.65. | |
| Darizmetinib | Darizmetinib (HRX-0215) is an orally active, potent and selective inhibitor of mitogen-activated protein kinase kinase 4 (MKK4). Darizmetinib leads to enhancement of the MKK7 and JNK1 signaling pathways, thereby activating the transcription factors ATF2 and ELK1, promoting cell proliferation and liver regeneration. Darizmetinib is promising for research of preventing liver failure after extensive oncological liver resections or transplantation of small liver grafts[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HRX-0215. CAS No. 2369583-33-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-152860. |  |
| DMX-5084 | DMX-5804 is a potent, selective and orally active inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 suppresses cell death in mouse myocardial infarction (MI), human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs), and 3D human engineered heart tissue. Synonyms: BCP30841. CAS No. 2306178-56-1. Molecular formula: C21H19N3O3. Mole weight: 361.39. | |
| Doramapimod | Doramapimod is a highly potent inhibitor of p38 mitogen-activated protein kinase (MAPK). Doramapimod is a potential agent for the treatment of inflammatory diseases. Doramapimod blocks baseline and bortezomib-triggered upregulation of p38 MAPK and Hsp27 phosphorylation leading to enhanced cytotoxicity and caspase activation. Group: Biochemicals. Alternative Names: N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea; BIRB 796BS; Birb 796. Grades: Highly Purified. CAS No. 285983-48-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| E6201 | E6201 is a synthetic, fungal metabolite analogue inhibitor of mitogen-activated protein kinase kinase 1 (MEK-1) and mitogen-activated protein kinase kinase kinase 1 (MEKK-1) with potential antipsoriatic and antineoplastic activities. MEK-1/MEKK-1 inhibitor E6201 specifically binds to and inhibits the activities of MEK-1 and MEKK-1, which may result in the inhibition of tumor cell proliferation. MEK-1 and MEKK-1 are key components in the RAS/RAF/MEK/MAPK signaling pathway, which regulates cell proliferation and is frequently activated in human cancers. Synonyms: E6201; E 6201; E-6201; ER 806201; ER806201; ER-806201; LL-Z1640-2. CAS No. 603987-35-5. Molecular formula: C21H27NO6. Mole weight: 389.45. | |
| ERK1/2 inhibitor 3 | ERK1/2 inhibitor 3, a potent ERK1/2 inhibitor, has the potential to study or prevent cancer, inflammation, or other proliferative diseases. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of MAPK family. (Extracted from patent WO2021218912A1, compound 1). Synonyms: (S)-2-(6-(5-chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1,1-dioxidobenzo[d]isothiazol-2(3H)-yl)-N-((S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl)propanamide. CAS No. 2737294-99-2. Molecular formula: C28H31ClFN5O6S. Mole weight: 620.09. | |
| ERK1/2 inhibitor 4 | ERK1/2 inhibitor 5, a potent ERK1/2 inhibitor, has the potential to study or prevent cancer, inflammation, or other proliferative diseases. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of MAPK family. (Extracted from patent WO2020238776A1). Synonyms: Thieno[3,2-c]pyridine-5(4H)-acetamide, 2-[5-chloro-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-N-[(1S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl]-6,7-dihydro-α-methyl-4-oxo-, (αR)-. CAS No. 2490396-99-9. Molecular formula: C28H31ClFN5O5S. Mole weight: 604.09. | |
| ERK1/2 inhibitor 6 | ERK1/2 inhibitor 6, a potent ERK1/2 inhibitor, has the potential to study or prevent cancer, inflammation, or other proliferative diseases. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of MAPK family. (Extracted from patent WO2021063335A1, compound 1). Synonyms: (R)-2-(6-(5-chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-4-oxopyrrolo[2,1-f][1,2,4]triazin-3(4H)-yl)-N-((S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl)propanamide. CAS No. 2634816-13-8. Molecular formula: C27H29ClFN7O5. Mole weight: 586.01. | |
| (E/Z)-BCI | (E/Z)-BCI is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. Synonyms: BCI; NSC 150117; 2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1h-inden-1-one. CAS No. 15982-84-0. Molecular formula: C22H23NO. Mole weight: 317.42. | |
| FR-167653 | FR-167653 is a p38 mitogen-activated protein kinase inhibitor, which suppresses the development of endometriosis in a murine model. FR-167653 meliorates murine bleomycin-induced pulmonary fibrosis. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: FR-167653; FR 167653; FR167653. CAS No. 158876-66-5. Molecular formula: C24H20FN5O6S. Mole weight: 525.51. | |
| FR-167653 Free base | FR-167653, a pyrazolo?triazin derivative, has been found to be a cytokine inhibitor as well as P38 mitogen-activated protein kinase inhibitor and was once studied as an anticoagulant. Synonyms: FR167653; FR-167653; FR 167653; 1,?2-Ethanedione, 1-[7-(4-fluorophenyl)?-3,?4-dihydro-8-(4-pyridinyl)?pyrazolo[5,?1-c]?[1,?2,?4]?triazin-2(1H)?-yl]?-2-phenyl-. Grade: 98%. CAS No. 158876-65-4. Molecular formula: C24H18FN5O2. Mole weight: 427.43. | |
| FTI-277 | FTI-277, a peptide mimetic of the COOH-terminal Cys-Val-Ile-Met of K-Ras4B that inhibited potently FTase in vitro (IC50 = 500 pM) and was highly selective for FTase over geranylgeranyltransferase I (GGTase I) (IC50 = 50 nM). FTI-277, the methyl ester derivative of FTI-276, was extremely potent (IC50 = 100 nM) at inhibiting H-Ras, but not the geranylgeranylated Rap1A processing in whole cells. Treatment of H-Ras oncogene-transformed NIH 3T3 cells with FTI-277 blocked recruitment to the plasma membrane and subsequent activation of the serine/threonine kinase c-Raf-1 in cells transformed by farnesylated Ras (H-RasF), but not geranylgeranylated, Ras (H-RasGG). FTI-277 induced accumulation of cytoplasmic non-farnesylated H-Ras that was able to bind Raf and form cytoplasmic Ras/Raf complexes in which Raf kinase was not activated. Furthermore, FTI-277 blocked constitutive activation of mitogen-activated protein kinase (MAPK) in H-RasF, but not H-RasGG, or Raf-transformed cells. FTI-277 also inhibited oncogenic K-Ras4B processing and constitutive activation of MAPK, but the concentrations required were 100-fold higher than those needed for H-Ras inhibition. The results demonstrate that FTI-277 blocks Ras oncogenic signaling by accumulating inactive Ras/Raf complexes in the cytoplasm, hence preventing constitutive activation of the MAPK cascade. Uses: Radiation-sensitizing agents. Synonyms: FTI-277; FTI 277; FTI277. CAS No. 170006-73-2. M | |
| G 573 | G 573 is used as an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor and an antineoplastic agent. Synonyms: Furo[3,2-c]pyridine-2-carboxamide, 7-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-N-[(2S)-2-hydroxypropoxy]-; 7-Fluoro-3-[(2-fluoro-4-iodophenyl)amino]-N-[(2S)-2-hydroxypropoxy]furo[3,2-c]pyridine-2-carboxamide; 7-Fluoro-3-[(2-fluoro-4-iodophenyl)amino]furo[3,2-c]pyridine-2-carboxylic acid N-[((S)-2-hydroxypropyl)oxy]amide; G-573; G573. Grade: 95%. CAS No. 1009333-44-1. Molecular formula: C17H14F2IN3O4. Mole weight: 489.21. | |
| Gamcemetinib | Gamcemetinib (CC-99677) is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM). Gamcemetinib is extracted from patent WO2020236636, compound 1[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CC-99677. CAS No. 1887069-10-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139504. | |
| Ganoderiol F | Lansiumarin C is a natural coumarin found in the branches of Clausena lansium. and found to induce senescence of cancer cell lines, it induces growth arrest of cancer cell lines HepG2, Huh7 and K562; activation of the mitogen-activated protein kinase EKR and up-regulation of cyclin-dependent kinase inhibitor p16 were found in early stages of Ganoderiol F treatment and were presumed to cause cell-cycle arrest and trigger premature senescence of HepG2 cells; suggests that the growth-arrest and senescence induction capability on cancer cells suggest anticancer potential of Ganoderiol F. It could be developed further as both anti-HIV and antimalaria.In Compared to plasmepsin I, ganoderiol-F is higher towards HIV-1 protease. Uses: Anti-inflammatory; anti-hiv. Synonyms: 26,27-Dihydroxylanosta-7,9(11),24-trien-3-one. Grade: >98%. CAS No. 114567-47-4. Molecular formula: C30H46O3. Mole weight: 454.7. | |
| GDC-0623 | GDC-0623 is an orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor GDC-0623 specifically inhibits mitogen-activated protein kinase kinase (MEK or MAP/ERK kinase), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers. Synonyms: GDC0623; GDC-0632; GDC 0632; G868; G 868; G-868. CAS No. 1168091-68-6. Molecular formula: C16H14FIN4O3. Mole weight: 456.216. | |
| GDC-0994 | GDC-0994, also known as RG7842, is an orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. This prevents ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. Uses: Antineoplastic agents. Synonyms: GDC0994; GDC 0994; RG7842; RG-7842; RG 7842; Ravoxertinib. CAS No. 1453848-26-4. Molecular formula: C21H18ClFN6O2. Mole weight: 440.863. | |
| GNE-495 | GNE-495 is a Selective MAP4K4 (Mitogen-activated protein kinase kinase kinase kinase 4) Inhibitor. IC50 value is 3.7 nM. GNE-495 shows excellent potency and good PK In vivo. GNE-495 was used to demonstrate in vivo efficacy in a retinal angiogenesis model recapitulating effects that are observed in the inducible Map4k4 knockout mice. Synonyms: GNE-495; GNE 495; GNE495. 8-amino-N-(1-(cyclopropanecarbonyl)azetidin-3-yl)-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide. Grade: 98%. CAS No. 1449277-10-4. Molecular formula: C22H20FN5O2. Mole weight: 405.43. | |
| Gossypetin | Gossypetin is a hexahydroxylated flavonoid and is a potent mitogen-activated protein kinase kinase (MKK)3 and MKK6 inhibitor with strongly attenuates the MKK3/6-p38 signaling pathway, has various pharmacological activities, including antioxidant, antibacterial and anticancer activities [1]. Uses: Scientific research. Group: Natural products. CAS No. 489-35-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-119917. | |
| GYY-4137 Morpholine salt | GYY-4137 Morpholine salt is a novel water-soluble and slow releasing Hydrogen sulfide(H2S) donor. It protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats. It inhibits the inflammatory response by suppressing the activation of nuclear factor-kappa B and mitogen-activated protein kinases in Coxsackie virus B3-infected rat cardiomyocytes. It exhibits potent anti-cancer activity. It exhibits vasodilator and antihypertensive activity in rats, in either the acute or chronic hypertension models. It does not influence vascular smooth muscle cell viability in culture. It also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production and reducing NF-κB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E2 generation. Uses: Gyy-4137 morpholine salt inhibits the inflammatory response. it exhibits potent anti-cancer activity. it exhibits vasodilator and antihypertensive activity. Synonyms: GYY4137; GYY-4137; GYY 4137; GYY 4137 morpholine salt; ZYJ1122; ZYJ 1122; ZYJ-1122. GYY4137 Morpholine salt; (4-Methoxyphenyl)morpholino-phosphinodithioic acid compound with morpholine; ZYJ1122 morpholine salt; ZYJ-1122 morpholine salt. Grade: ≥95%. CAS No. 106740-09-4. Molecular formula: C15H25N2O3PS2. Mole weight: 376.47. | |
| IN-1130 | IN-1130 is a highly selective transforming growth factor-? type I receptor kinase (ALK5) inhibitor with an IC50 of 5.3 nM for ALK5-mediated Smad3 phosphorylation. IN-1130 inhibits ALK5 phosphorylation of casein (IC50=36 nM) and p38? mitogen-activated protein kinase (IC50=4.3 ?M). IN-1130 suppresses renal fibrosis in obstructive nephropathy and blocks breast cancer lung metastasis[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 868612-83-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18758. | |
| ISCK03 | ISCK03 is a potent c-kit inhibitor. ISCK03 inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. ISCK03 also inhibited p44/42 ERK mitogen-activated protein kinase (MAPK) phosphorylation, which is known to be involved in SCF/c-kit downstream signaling. ISCK03 might be used as skin-whitening agents. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ISCK03, ISCK-03, ISCK 03. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 945526-43-2. Molecular formula: C19H21N3O2S. Mole weight: 355.46. Purity: >98%. IUPACName: [4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide. Canonical SMILES: O=S(N(C1=CC=C(C(C)(C)C)C=C1)C2=CC=C(N3C=CN=C3)C=C2)=O. Product ID: ACM945526432-2. Alfa Chemistry ISO 9001:2015 Certified. | |
| L-a-lysophosphatidyl inositol Sodium Salt, Soy (L-a-lysophosphatidyl inositol LPI, Lyso PI, Soy Lyso PI) | A potent agonist and assumed endogenous ligand of GPR55, shown to induce rapid phosphorylation of p38 mitogen-activated protein kinase (MAPK) and its downstream activating transcription factor 2 (ATF2) in both GPR55-transfected HEK293 cells, and in IM-9 lymphoblastoid cells naturally expressing GPR55 at 1uM, while having no effect on vector-transfected cells. In addition, shown to enhance serum induced cell migration in MCF-7 cells over expressing GPR55. Group: Biochemicals. Grades: Highly Purified. CAS No. 796963-91-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MEK1 Derived Peptide Inhibitor 1 | It is a peptide composed of the first 13 amino acids of the human mitogen-activated protein kinase kinase-1 (MEK1). It inhibits the in vitro activation of ERK2 by MEK1. Synonyms: H-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-OH; L-methionyl-L-prolyl-L-lysyl-L-lysyl-L-lysyl-L-prolyl-L-threonyl-L-prolyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-asparagyl-L-proline. Grade: >98%. Molecular formula: C68H118N18O17S. Mole weight: 1491.84. | |
| Mitogen activated protein kinase from rat, Recombinant | Mitogen-activated protein kinases (MAPK) are protein kinases that are specific to the amino acids serine, threonine, and tyrosine. MAPKs belong to the CMGC (CDK/MAPK/GSK3/CLK) kinase group. MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis. > 95% (sds-page), buffered aqueous glycerol solution, recombinant, expressed in e. coli (n-terminal histidine tagged). Group: Enzymes. Synonyms: ERK2; Extracellular-signal regulated kinase; MAP Kinase Activated from rat; MAPK; Mitogen activated protein kinase. Purity: > 95% (SDS-PAGE). MAP kinase. Mole weight: mol wt 42 kDa. Activity: > 500 U/mg. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: E. coli. Species: Rat. ERK2; Extracellular-signal regulated kinase; MAP Kinase Activated from rat; MAPK; Mitogen activated protein kinase. Pack: vial of 100 ng. Cat No: NATE-0443. | |
| N-Decanoyl-L-homoserine lactone | N-decanoyl-L-homoserine lactone (C10-HSL) is a N-acyl-homoserine lactone (AHL) N-decanoyl-L-homoserine lactone can inhibit primary root growth in Arabidopsis. N-decanoyl-L-homoserine lactone triggers a transient and immediate increase in the concentrations of cytosolic free Ca 2+ and reactive oxygen species ( ROS ), increases the activity of mitogen-activated protein kinase 6 ( MPK6 ), and induces nitric oxide ( NO ) production in Arabidopsis roots [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: C10-HSL. CAS No. 177315-87-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136409. | |
| Neochinulin A | Neoechinulin A is isolated from Aspergillus chevalieri. It may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regulating kinase 1 (ASK-1) and nuclear translocation of nuclear factor-κB (NF-κB) p65 and p50 subunits. Uses: Antioxidant; anti-inflammatory; antioxidant/anti-nitration. Synonyms: (3S,6Z)-3-Methyl-6-{[2-(2-methyl-3-buten-2-yl)-1H-indol-3-yl]meth ylene}-2,5-piperazinedione; (3S)-3α-Methyl-6-[(Z)-[2-(1,1-dimethyl-2-propenyl)-1H-indole-3-yl]methylene]hexahydropyrazine-2,5-dione. Grade: 97%. CAS No. 51551-29-2. Molecular formula: C19H21N3O2. Mole weight: 323.4. | |
| N-Methylparoxetine | N-Methylparoxetine is a derivative of Paroxetine that induces Apoptosis NSCLC cells by activating mitogen-activated protein kinase ( MAPK ). N-Methylparoxetine has antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 110429-36-2. Pack Sizes: 250 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-Z3832. | |
| non-specific serine/threonine protein kinase | This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date. Group: Enzymes. Synonyms: A-kinase; AP50 kinase; ATP-protein transphosphorylase; calcium-dependent protein kinase C; calcium/phospholipid-dependent protein kinase; cAMP-dependent protein kinase; cAMP-dependent protein kinase A; casein kinase; casein kinase (phosphorylating); casein kinase 2; casein kinase I; casein kinase II; cGMP-dependent protein kinase; CK-2; CKI; CKII; cyclic AMP-dependent protein kinase; cyclic AMP-dependent protein kinase A; cyclic monophosphate-dependent protein kinase; cyclic nucleotide-dependent protein kinase; cyclin-dependent kinase; cytidine 3',5'-cyclic monophosphate-responsive protein kinase; dsk1; glycogen synthase a kinase; glycogen synthase kinase; HIPK2; Hpr kinase; hydroxyalkyl-protein kinase; hydroxyalkyl-protein kinase; M phase-specific cdc2 kinase; mitogen-activated S6 kinase; p82 kinase; phosphorylase b kinase kinase; PKA; protein glutamyl kinase; pr. Enzyme Commission Number: EC 2.7.11.1. STK. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3128; non-specific serine/threonine protein kinase; EC 2.7.11.1; A-kinase; AP50 kinase; | |
| NSC 95397 | NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor (Ki=32 nM (Cdc25A), 96 nM (Cdc25B), 40 nM (Cdc25C); IC50=22.3 nM (human Cdc25A), 56.9 nM (human Cdc25C), 125 nM (Cdc25B))[1]. NSC 95397 inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 93718-83-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108543. | |
| PF-3644022 | PF-3644022 is a potent freely reversible ATP-competitive compound that inhibits MK2 activity (Ki = 3 nM) with good selectivity when profiled against 200 human kinases. PF-3644022 is a benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor α production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. Group: Biochemicals. Alternative Names: (10R)-9, 10, 11, 12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1, 4]diazepino[5', 6':4, 5]thieno[3, 2-f]quinolin-8-one. Grades: Highly Purified. CAS No. 1276121-88-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PHA 767491 Dihydrochloride Salt | A potent and selective ATP-competitive dual inhibitor cdc7/cdk9. It blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites. Inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo. Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2). Group: Biochemicals. Alternative Names: 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one Dihydrochloride;PHA 767491 Dihydrochloride Salt; PF-02334471. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Phorbol 12-myristate 13-acetate (PMA, TPA, 12-O-Tetradecanoylphorbol 13-acetate) | Most commonly-used phorbol ester. Binds to and activates protein kinase C (PKC) at nM concentrations. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors such as p21WAF1/CIP1, p27KIP1, p15 and p16. Potent mouse skin tumor promoter. Promoter of inducible NOS (iNOS; NOS II). Apoptosis inducer. Potential effective cancer therapeutic agent. Inhibitor of anti-lipolytic activity of insulin. Group: Biochemicals. Alternative Names: PMA; TPA; 12-O-Tetradecanoylphorbol 13-acetate. Grades: Highly Purified. CAS No. 16561-29-8. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C36H56O8, Molecular Weight: 616.83. US Biological Life Sciences. | Worldwide |
| PLX4032 (Vemurafenib) | Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600. Group: Biochemicals. Alternative Names: N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide; PLX4032; RG7204; RO51-85426; Zelboraf. Grades: Highly Purified. CAS No. 918504-65-1. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. US Biological Life Sciences. | Worldwide |
| Rhein | Rhein is a lipophilic anthraquinone extensively found in medicinal herbs, and has many pharmacological effects, including epatoprotective, nephroprotective, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities.IC50 value:Target:In vitro: Rhein (0.1 and 1 mg/mL) evidently suppressed cell proliferation and mitogen-activated protein (MAP) kinase activation in human colon adenocarcinoma cells (Caco-2) but significantly lessened H2O2-induced DNA damage and the elevated MDA and ROS levels induced by H2O2/Fe2+ at the concentrations of 0.1-10 mg/mL.In vivo: Oral administration of rhein (150 mg/kg/d) evidently ameliorated renal interstitial fibrotic lesions and attenuated the expression of α-SMA and deposition of fibronectin (FN) in mice with renal interstitial fibrosis induced by unilateral ureteral obstruction. Rhein also suppressed TGF-β1 and its type I receptor expression in obstructed kidneys. The biochemical parameters results of IgAN model rats showed that rhein-prevented and rhein-treated both improved the biochemical parameters and relieved renal pathological injury. The expressions of renal tissue TLR4, TGF-β1, but not TLR9 were significantly elevated in IgAN model rats (P < 0.05). Rhein-prevented and rhein-treated both inhibited TLR4 and TGF-β1 expressions. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Chrysazin-3-carboxylicacid. Product Cat | |
| Rineterkib free base | Rineterkib, also known as LTT-462 or ERK-IN-1, is a ERK1/2 inhibitor which has demonstrated preclinical activity in multiple MAPK activated cancer cells and xenograft models. LTT462 binds to and inhibits ERK, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in numerous tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Rineterkib; ERK-IN-1; ERK IN 1; ERK IN-1; ERK-IN 1; LTT 462; LTT-462; LTT462. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1715025-32-3. Molecular formula: C26H27BrF3N5O2. Mole weight: 578.43. Purity: >98%. IUPACName: 4-{3-amino-6-[(1S,3S,4S)-3-fluoro-4-hydroxycyclohexyl]pyrazin-2-yl}-N-[(1S)-1-(3-bromo-5-fluorophenyl)-2-(methylamino)ethyl]-2-fluorobenzamide. Canonical SMILES: O=C(N[C@@H](C1=CC(F)=CC(Br)=C1)CNC)C2=CC=C(C3=NC([C@@H]4C[C@H](F)[C@@H](O)CC4)=CN=C3N)C=C2F. Product ID: ACM1715025323. Alfa Chemistry ISO 9001:2015 Certified. | |
| (R)-Roscovitine | Potent and selective inhibitor of CDKs. More potent than olomoucine. Inhibits CDK1/cyclin B kinase (IC50 = 450nM), CDK2 (IC50 = 700nM) and CDK5/p35 (IC50 = 160nM). Inhibits M phase promoting factor (MPF) kinase activity. Arrests human fibroblasts in G1 phase. Antitumor compound. Activates the mitogen-activated protein kinase pathway. Targets both the p53 and NF-kappaB pathways. Has effects on calcium channel gating. Prevents DNA damage-induced cyclin A1 upregulation. Apoptosis inducer. As CYC202 in phase I clinical trials. Group: Biochemicals. Alternative Names: (2R)-2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol; (R)-2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol; 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine; CYC 202; (R)-Roscovitine; R-Roscovitine; Roscovitin; Seliciclib. Grades: Highly Purified. CAS No. 186692-46-6. Pack Sizes: 1mg, 5mg, 50mg. Molecular Formula: C??H??N?O. US Biological Life Sciences. | Worldwide |
| (R)-Semivioxanthin | Mycotoxin. Antibacterial (Gram-positive) and antifungal. Immunoregulator by degradation of IkappaB (Inhibitor of NF-kappaB) and regulation of the TNF-alpha (tumor necrosis factor-alpha) and MAPK (mitogen-activated protein kinase) signaling pathways. Group: Biochemicals. Alternative Names: (3R)-3,4-Dihydro-9,10-dihydroxy-7-methoxy-3-methyl-1H-naphtho[2,3-c]pyran-1-one; (+)-Semi-vioxanthin; (R)-semi-Vioxanthin; Semivioxanthin. Grades: Highly Purified. CAS No. 70477-26-8. Pack Sizes: 500ug, 1mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| Skepinone-L | Skepinone-L (CBS3830) is a selective p38 mitogen-activated protein kinase inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CBS3830. CAS No. 1221485-83-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15300. | |
| (S)-p38 MAPK Inhibitor III | (S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro). It is cell-permeable, potently blocking the release of TNF-α and IL-1β from human peripheral blood mononuclear cells (IC50s = 0.37 and 0.044 μM, respectively). Synonyms: (S)-p38 MAP Kinase Inhibitor III; 4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-2-pyridinamin; (S)-p38 Mitogen-activated Protein Kinase Inhibitor III. Grade: ≥98%. CAS No. 581098-48-8. Molecular formula: C23H21FN4S. Mole weight: 404.5. | |
| Strontium Ranelate | Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate can also activate the calcium-sensing receptor (CaSR) in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activated protein kinase signaling [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Distrontium renelate; S12911. CAS No. 135459-87-9. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-17397. | |
| Vemurafenib, Free Base (PLX4032) | Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600. Group: Biochemicals. Alternative Names: N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide; PLX4032; RG7204; RO51-85426; Zelboraf. Grades: Highly Purified. CAS No. 918504-65-1. Pack Sizes: 25mg, 50mg, 100mg. US Biological Life Sciences. | Worldwide |
| VX 745 | VX 745 is a potent and selective inhibitor of p38α mitogen-activated protein (MAP) kinase. VX 745 is a potential anti-inflammatory agents. Studies suggest that VX 745 may be useful in the treatment of Werner syndrome. Group: Biochemicals. Alternative Names: 5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one. Grades: Highly Purified. CAS No. 209410-46-8. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Wortmannin | Antibiotic. Potent anti-neutrophil agent with cardioprotective effects. mTOR, DNA-PK, phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) inhibitor at high concentrations. Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K). Antitumor compound. Radiosensitizing agent. Adipogenesis inhibitor. Angiogenesis inhibitor. Autophagy inhibitor. DNA repair, receptor-mediated endocytosis and cell proliferation inhibitor. Potentiates the LPS-induced nitric oxide (NO) production from macrophages. Induces in vivo Alzheimer-like hyperphosphorylation in tau. Polo-like kinase family inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 19545-26-7. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C23H24O8. US Biological Life Sciences. | Worldwide |
| Zunsemetinib | Zunsemetinib (CDD-450) is an orally active and selective p38? mitogen-activated protein kinase-activated protein kinase 2 (MK2) pathway inhibitor. Zunsemetinib can be used for the research of immuno-inflammatory diseases[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ATI-450; CDD-450. CAS No. 1640282-42-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-139553. | |
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