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The zymogen factor IX is a single chain vitamin K-dependent glycoprotein which is synthesized in the liver. The domain structure of factor IX is similar to that of the other vitamin K dependent coagulation factors. The NH2-terminal region contains 12 γ-carboxyglutamic acid (gla) residues which facilitate the calcium dependent binding of factor IX to negatively charged phospholipid surfaces. Two domains which are homologous to epidermal growth factor (EGF) span the region between the NH2-terminal gla domain and the activation peptide (Ala-146 to Arg-180).Factor IX is activated by either factor XIa or the factor VIIa/tissue factor/phospholipid complex. Cleavage at site A (see fig...factor VIIIa/IXa/Ca2+/phospholipid) which proteolytically activates factor X to factor Xa.Human factor IX is prepared from fresh frozen plasma by a combination of conventional procedures and immunoaffinity chromatography. Bovine factor IX is prepared from fresh citrated bovine plasma by a modification of the method described by Fujikawa et al. The purified proteins are supplied in 50% (vol/vol) glycerol/H2O and should be stored at -20°C. Purity is determined by SDS-PAGE analysis and activity is measured using a factor IX clotting assay. Group: Zymogens. Purity: >95%. Factor IX. Mole weight: 55000. Storage: -20°C. Source: Mouse. Mouse factor IX; Factor IX. Pack: 50 ug. Cat No: CZY-032.
Mouse Factor X
Factor X is a vitamin K-dependent protein zymogen which is synthesized in the liver and circulates in plasma as a two chain molecule linked by a disulfide bond. Prior to secretion into plasma, post-translational modifications produce 11 gamma-carboxyglutamic acid (gla) residues and a single b-hydroxyaspartic acid residue, which are located within the NH2-terminal light chain. The light chain also contains two epidermal growth factor (EGF) homology domains. The COOH-terminal heavy chain of factor X contains most of the carbohydrate moieties, as well as the latent serine protease domain. The activation of factor X is catalyzed by either the intrinsic factor Xase complex (factor IXa, fac...y of the prothrombinase complex. The first EGF homology domain contains a Ca2+ binding site which acts as a hinge to fold the EGF and GLA domains towards each other. This region of the molecule is involved in the recognition of cellular binding domains.Human factor X is isolated from fresh frozen human plasma by a combination of conventional techniques and immunoaffinity chromatography. In addition to the standard human factor X preparation, Gla-domainless human factor X is also available. Bovine factor X is isolated from fresh bovine plasma using a modification of the procedure reported by Bajaj et al. The purified zymogen is supplied in 50% (vol/vol) glycerol/H2O and should be store
Mouse Genotyping Kit
Mouse Genotyping Kit. Mouse genotyping kit uses a unique lysis buffer to prepare mouse genotyping pcr-ready dna from fresh or frozen mouse tissue slices, such as mouse ears, toes and tails. Group: Cloning Enzymes. Purity: 100×; 500×. Storage: Store at -20 ?. Cat No: CE-3013.
Mouse glu-Plasminogen
Plasminogen is a single chain glycoprotein zymogen which is synthesized in the liver and circulates in plasma at a concentration of approximately 2.4 uM. The plasminogen molecule contains 790 amino acids, 24 disulfide bridges, no free sulfhydryls and 5 regions of internal sequence homology, known as kringles, between Lys77 and Arg560. These five triple-looped, three disulfide bridged, kringle regions are homologous to the kringle domains in t-PA, u-PA and prothrombin. Plasminogen contains one high affinity (Kd=9x10-6M) and four low affinity (Kd=5x10-3M) lysine binding sites. The high affinity binding site resides within the first kringle region of plasminogen. The interaction of p...tly associated by a disulfide bond.Native glu-plasminogen is prepared from fresh frozen human plasma by a modification of the procedure of Castellino, utilizing gel filtration and affinity chromatography. The two carbohydrate variants of glu-plasminogen (CHOI and CHOII) are isolated by gradient elution from lysine-Sepharose using the lysine analog, e-aminocaproic acid. The plasminogen is supplied in 50% (vol/vol) glycerol/H2O for storage at -20°C. Purity is determined by SDS-PAGE analysis. Group: Zymogens. Purity: >95% by SDS-PAGE. Plasminogen. Mole weight: 88000. Stability: 12 months. Storage: -20°C. Source: Mouse. Mouse glu-Plasminogen; Plasminogen. Pack: 100 ug. Cat No: CZY-016.
Mouse Metabolite Compound Library
A unique collection of 203 mouse metabolites, which can be used for HTS and HCS; - Effective tool for research in metabonomics; - Some compounds have been approved by the FDA or are undergoing clinical trials; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L2530. Categories: Mouse Metabolite Compounds Libraries.
Mouse Negative Control, Ascites
Mouse ascites obtained from mice bearing different hybridomas, delipidated, heat-inactivated, pooled and depleted of all immunoglobulins. Group: Biologicals. Grades: Purified. Pack Sizes: 500ul. US Biological Life Sciences.
Worldwide
Mouse Prothrombin
Prothrombin is a vitamin K-dependent plasma protein which is synthesized in the liver. Prior to secretion into plasma, prothrombin undergoes post-translational modification by a vitamin K-dependent carboxylase which converts ten specific glutamic acid residues to γ-carboxyglutamic acid (gla). The ten gla residues are located within the first 40 amino acids of the mature protein and contribute to the ability of prothrombin to bind to negatively charged phospholipid membranes. Prothrombin contains two regions of internal homology which are referred to as "kringle" structures. These regions of conspicuous secondary structure are located between residues 40 and 270 of the mature p...-Ser321 (human) / Arg323-Ser324 (bovine) to a "pro" fragment (fragment 1.2) and thrombin, the latter of which is composed of two chains covalently linked by a disulfide bond. In the case of human prothrombin/thrombin, there is an additional thrombin feed-back cleavage at Arg284-Thr285 resulting in an additional 13 amino acids being removed from the mature thrombin A chain.Human prothrombin is prepared from fresh frozen human plasma as described by Bajaj and coworkers. Bovine prothrombin is prepared from fresh bovine plasma using a modification of the procedure described by Owen and coworkers. Purified prothrombin is supplied in 50% (vol/vol) glycerol/H2O and should be stored at -20
Acetyl PACAP (1-38) (human, mouse, ovine, porcine, rat) trifluoroacetate salt
Acetyl pituitary adenylate cyclase-activating peptide (PACAP) (1-38) is an N-terminally acetylated form of PACAP (1-38). Synonyms: Acetyl pituitary adenylate cyclase-activating peptide (1-38). Grades: ≥95%. Molecular formula: C205H333N63O54S·xCF3COOH. Mole weight: 4576.29.
ACTH (1-13) (human, mouse, rat, porcine, bovine, ovine) trifluoroacetate salt
ACTH (1-13) is a peptide fragment of adrenocorticotropic hormone, a peptide hormone found in the brain that is involved in the biological stress response. Synonyms: SYSMEHFRWGKPV-OH. Grades: ≥98%. Molecular formula: C75H106N20O19S·xCF3COOH. Mole weight: 1623.83.
ACTH (1-17) (human, mouse, rat, porcine, bovine, ovine) trifluoroacetate salt
ACTH (1-17) is a peptide fragment of adrenocorticotropic hormone, a peptide hormone found in the brain that is involved in the biological stress response. Synonyms: Adrenocorticotropic hormone (1-17); SYSMEHFRWGKPVGKKR-OH; Cortrophin; Corticotrophin. Grades: ≥98%. Molecular formula: C95H145N29O23S·xCF3COOH. Mole weight: 2093.42.
ACTH (4-10) (human, mouse, rat, porcine, bovine, ovine) trifluoroacetate salt
Adrenocorticotropic hormone (ACTH) (4-10) is an endogenous peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response. Synonyms: Adrenocorticotropic hormone (4-10); Corticotropin (4-10); H-Met-Glu-His-Phe-Arg-Trp-Gly-OH. Grades: ≥95%. Molecular formula: C44H59N13O10S·xCF3COOH. Mole weight: 962.09.
ACTH (6-24) (human, mouse, rat, porcine, bovine, ovine) trifluoroacetate salt
ACTH (6-24) is a peptide fragment of adrenocorticotropic hormone, a peptide hormone found in the brain that is involved in the biological stress response. Synonyms: HFRWGKPVGKKRRPVKVYP; Corticotropin-(6-24)-peptide. Grades: ≥95%. CAS No. 33512-65-1. Molecular formula: C111H175N35O21·xCF3COOH. Mole weight: 2335.8.
Adropin (34-76) (human, mouse, rat)
Adropin (34-76) is a secretory domain of Adropin. Adropin (34-76) can inhibit cAMP level and glucose production in hepatocytes, and has a hypoglycemic effect. Adropin (34-76) plays an antifibrotic role by inhibiting the GLI1 signaling pathway [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 1802086-30-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4860.
Adropin (34-76) (human, mouse, rat)
Adropin, a secreted factor involved in energy homeostasis and lipid metabolism, is encoded by the energy homeostasis-related gene (Enho) and expressed in the liver and brain. In diet-induced obesity (DIO) mice, adropin (34-76) reduced hepatosteatosis and insulin resistance, regardless of obesity or food intake. In addition, adropin could be a regulator of endothelial function. Synonyms: H-Cys-His-Ser-Arg-Ser-Ala-Asp-Val-Asp-Ser-Leu-Ser-Glu-Ser-Ser-Pro-Asn-Ser-Ser-Pro-Gly-Pro-Cys-Pro-Glu-Lys-Ala-Pro-Pro-Pro-Gln-Lys-Pro-Ser-His-Glu-Gly-Ser-Tyr-Leu-Leu-Gln-Pro-OH (Disulfide bridge: Cys1-Cys23); L-Cysteinyl-L-histidyl-L-seryl-L-arginyl-L-seryl-L-alanyl-L-alpha-aspartyl-L-valyl-L-alpha-aspartyl-L-seryl-L-leucyl-L-seryl-L-alpha-glutamyl-L-seryl-L-seryl-L-prolyl-L-asparaginyl-L-seryl-L-seryl-L-prolylglycyl-L-prolyl-L-cysteinyl-L-prolyl-L-alpha-glutamyl-L-lysyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-glutaminyl-L-lysyl-L-prolyl-L-seryl-L-histidyl-L-alpha-glutamylglycyl-L-seryl-L-tyrosyl-L-leucyl-L-leucyl-L-glutaminyl-L-proline cyclic (1?23)-disulfide. Grades: ≥95%. CAS No. 1802086-30-1. Molecular formula: C190H293N55O68S2. Mole weight: 4499.82.
(Ala11.22.28)-VIP (human, mouse, rat)
(Ala11.22.28)-VIP (human, mouse, rat), a highly selective human VPAC1 receptor agonist, shows a 1000-fold higher efficiency in stimulating adenylate cyclase activity from VPAC1 than VPAC2 receptors. It is a valid pharmacological tool for characterizing VPAC1 receptor-mediated events. Synonyms: (Ala11.22.28)-Aviptadil; H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Ala-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Ala-Leu-Asn-Ser-Ile-Leu-Ala-NH2; L-histidyl-L-seryl-L-alpha-aspartyl-L-alanyl-L-valyl-L-phenylalanyl-L-threonyl-L-alpha-aspartyl-L-asparagyl-L-tyrosyl-L-alanyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-methionyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-asparagyl-L-seryl-L-isoleucyl-L-leucyl-L-alaninamide. Grades: ≥95% by HPLC. CAS No. 291524-04-4. Molecular formula: C139H231N43O39S. Mole weight: 3160.65.
(Ala13)-Apelin-13 acetate salt (human, bovine, mouse, rat)
(Ala13)-Apelin-13 acetate salt (human, bovine, mouse, rat) is an antioxidant with the ability to scavenge active oxygen species such as superoxide and hydroxyl radicals, and may have therapeutic effects on diseases (such as arthritis and cancer) damaged by hydroxyl radicals. Synonyms: H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala-OH acetate salt; L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysyl-glycyl-L-prolyl-L-methionyl-L-prolyl-L-alanine acetate salt. Molecular formula: C63H107N23O16S.C2H4O2. Mole weight: 1534.81.
(Ala13)-Apelin-13 (human, bovine, mouse, rat)
(Ala13)-Apelin-13 (human, bovine, mouse, rat) is an antioxidant with the ability to scavenge active oxygen species such as superoxide and hydroxyl radicals, and may have therapeutic effects on diseases (such as arthritis and cancer) damaged by hydroxyl radicals. Synonyms: (Ala13)-Apelin 13, human; H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala-OH; L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysyl-glycyl-L-prolyl-L-methionyl-L-prolyl-L-alanine; L-Glutaminyl-N5-(diaminomethylene)-L-ornithyl-L-prolyl-N5-(diaminomethylene)-L-ornithyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-alanine; Apelin 13 F13A. Grades: ≥95%. CAS No. 568565-11-7. Molecular formula: C63H107N23O16S. Mole weight: 1474.73.
(Ala1)-PAR4 (1-6) amide (mouse) trifluoroacetate salt
(Ala1)-PAR4 (1-6) amide (mouse) is a peptide agonist of proteinase-activated receptor 4 (PAR4) that induces aggregation of rat and human platelets in vitro (EC50s = 15 and 60 μM, respectively). Synonyms: AY-NH2; AYPGKF-NH2; H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2; PAR4-AP; Proteinase-Activated Receptor 4 Activating Peptide; L-alanyl-L-tyrosyl-L-prolylglycyl-L-lysyl-L-phenylalaninamide trifluoroacetate salt. Grades: ≥95%. Molecular formula: C34H48N8O7·xCF3COOH. Mole weight: 680.79.
(Ala1)-PAR-4 (1-6) (mouse)
(Ala1)-PAR-4 (1-6) (mouse) is a peptide used in compound to study the role of PAR-4 (Prostate Apoptosis Response 4) in mice. It is specifically designed to mimic the first six amino acids of mouse PAR-4 and is utilized to investigate its function and potential therapeutic targets in diseases such as cancer and apoptosis-related disorders. Synonyms: (Ala1)-Thrombin Receptor-Like 3 (1-6) (mouse); H-AYPGKF-OH; L-alanyl-L-tyrosyl-L-prolyl-glycyl-L-lysyl-L-phenylalanine; (Ala1)-Proteinase Activated Receptor 4 (1-6) (Mouse); (Ala1)-Coagulation Factor II Receptor-Like 3 (1-6) (Mouse). Grades: ≥95%. CAS No. 380900-00-5. Molecular formula: C34H47N7O8. Mole weight: 681.78.
(Ala1)-PAR4 (1-6) (mouse) trifluoroacetate salt
(Ala1)-PAR4 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 4 (PAR4) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse PAR4 and residues 60-65 of the full-length sequence with an alanine residue substituted for glycine at position 1/60. Synonyms: H-Ala-Tyr-Pro-Gly-Lys-Phe-OH; L-alanyl-L-tyrosyl-L-prolylglycyl-L-lysyl-L-phenylalanine trifluoroacetate salt. Grades: ≥95%. Molecular formula: C34H47N7O8·xCF3COOH. Mole weight: 681.78.
Alkaline phosphatase (ALP, ALKP, ALPase, Alk Phos) (EC 3.1.3.1) is a hydrolase enzyme responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. The process of removing the phosphate group is called dephosphorylation. As the name suggests, alkaline phosphatases are most effective in an alkaline environment. It is sometimes used synonymously as basic phosphatase. Group: Enzymes. Synonyms: Alpl; Akp-2; Akp2; ALP; APTNAP; TNAP; TNSALP; HOPS; tissue-nonspecific isozyme. Enzyme Commission Number: EC 3.1.3.1. Purity: > 95% by SDS-PAGE. ALP. Mole weight: 54.5 kDa. Activity: > 46,000 pmol/min/ug. Storage: Store at +4°C for short term (1-2 weeks). For long term storage, aliquot and store at -70°C. Avoid repeated freeze/thaw cycles. Form: Liquid. Source: Insect cell (Baculovirus) and fused to His-tag at C-terminus. Species: Mouse. Alkaline phosphatase; ALP; ALKP; ALPase; Alk Phos; EC 3.1.3.1; Alkaline phosphomonoesterase; Glycerophosphatase; Phosphomonoesterase; Alpl; Akp-2; Akp2; APTNAP; TNAP; TNSALP; HOPS; tissue-nonspecific isozyme. Cat No: NATE-1634.
Amylin (rat, mouse) trifluoroacetate salt
Amylin is a pancreatic β-cell hormone that produces effects in several different organ systems. Amylin is a 37-amino-acid peptide that activates its specific receptors, which are multisubunit G protein and resulting in multiple receptor subtypes. Amylin's major role is as a glucoregulatory hormone, and it is an important regulator of energy metabolism in health and disease. Amidated amylin increases the rate of glycogen synthesis induced by insulin in isolated rat soleus muscle when used at a concentration of 1 nM, while linear non-amidated amylin has no effect. Synonyms: IAPP (rat, mouse); Islet Amyloid Polypeptide (rat, mouse). Grades: ≥95%. Molecular formula: C167H272N52O53S2·xCF3COOH. Mole weight: 3920.40.
Angiotensin I (human, mouse, rat)
Angiotensin 1 (Human), an endogenous peptide substrate for angiotensin converting enzyme (ACE), is precursor to the vasoconstrictor peptide angiotensin II. Synonyms: Angiotensin 1 Human; H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH; L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucine; Pepsitensin; Proangiotensin; 5-Ile-angiotensin I; 5-L-Isoleucine-angiotensin I. Grades: ≥95%. CAS No. 484-42-4. Molecular formula: C62H89N17O14. Mole weight: 1296.48.
Angiotensin I (human, mouse, rat)
Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensin II, cleaved by the angiotensin-converting enzyme (ACE). Uses: Scientific research. Group: Peptides. CAS No. 484-42-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P1032.
Angiotensin I (human, rat, mouse) trifluoroacetate salt
Angiotensin I is formed from angiotensinogen by the action of renin, which is released from the kidney juxtaglomerular cells. Angiotensin I is further cleaved to angiotensin II by angiotensin converting enzyme. Angiotensin is a protein hormone that causes blood vessels to become narrower. It helps to maintain blood pressure and fluid balance in the body. It binds to angiotensin receptors in human myometrium membrane preparations with Kd of 11.2 nM and increases renal vascular resistance in isolated rat kidney with EC50 of 10.5 nM. Grades: ≥95%. Molecular formula: C62H89N17O14·xCF3COOH. Mole weight: 1296.48.
Angiotensin III (human, mouse)
Angiotensin III (Ang III) is generated from Ang II by APA (and subsequently degraded by aminopeptidase N), and that central Ang III seems to play a key-role in vasopressin release and BP control. Angiotensin III, human, mouse is a heptapeptide agonist, which acts as an endogenous angiotensin type 2 receptor (AT2R) agonist. The IC50 values for AT2R is 0.648 nM and the IC50 values for AT1R is 21.1 nM. The biologically active COOH-terminal heptapeptide angiotensin III is bound more tightly than angiotensin II. Synonyms: H-Arg-Val-Tyr-Ile-His-Pro-Phe-OH; L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine; Ang III; Angiotensin III; 5-Ile-angiotensin III; 1-Desaspartyl-5-isoleucine angiotensin II; Des-asp(1)-(Ile(5))-angiotensin II; N5-(Diaminomethylene)-L-ornithyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine; 2-8-angiotensin II, 5-L-isoleucine-. Grades: ≥95%. CAS No. 13602-53-4. Molecular formula: C46H66N12O9. Mole weight: 931.09.
Apelin-36 (rat, mouse)
Apelin-36 (rat, mouse). Group: Biochemicals. Grades: Purified. CAS No. 230299-95-3. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Apelin-36 (rat, mouse)
Apelin-36 (rat, mouse) is an endogenous ligand of the G protein-coupled APJ receptor with EC50 value of 5.4 nM that is secreted by adipocytes. It potently inhibits cAMP production in vitro. It is important in regulating fluid homeostasis, cardiovascular function and feeding. It potently blocks HIV-1 and HIV-2 strains entry into cells expressing APJ and CD4 and limits HIV infection. Synonyms: Apelin-36 (rat, mouse); Apelin 36 (rat, mouse); Apelin36 (rat, mouse). Grades: 95%. CAS No. 230299-95-3. Molecular formula: C185H304N68O43S. Mole weight: 4200.93.
APRIL from mouse
APRIL (a proliferation-inducing ligand), also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13), is a protein of the TNF superfamily recognized by the cell surface receptor TACI. APRIL protein (CD256) can induce proliferation, regulate tumor cell growth, and may participate in mononuclear/macrophage-mediated immune process. APRIL protein has been widely used in the study of lymphatic malignancies. Synonyms: A Proliferating-inducing Ligand; TNFSF13; TRDL-1a; APRIL/TNFSF13 Protein, Mouse; rMuApril/TNFSF13; TNFSF 13; TNFSF-13; CD256. Grades: ≥98% by HPLC. Mole weight: ~21.9 kDa.
(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat)
(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) is an effective antagonist against pTH-stimulated cAMP production in ROS cells and shows no partial agonism effect. Synonyms: (Asn10,Leu11,D-Trp12)-Hypercalcemia of Malignancy Factor (7-34) amide (human, mouse, rat); H-Leu-Leu-His-Asn-Leu-D-Trp-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-NH2; L-Leucyl-L-leucyl-L-histidyl-L-asparaginyl-L-leucyl-D-tryptophyl-L-lysyl-L-seryl-L-isoleucyl-L-glutaminyl-L-α-aspartyl-L-leucyl-L-arginyl-L-arginyl-L-arginyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-histidyl-L-histidyl-L-leucyl-L-isoleucyl-L-alanyl-L-α-glutamyl-L-isoleucyl-L-histidyl-L-threonyl-L-alaninamide; (Asn10,Leu11,D-Trp12)-pTHrP (7-34) amide. Grades: ≥95%. CAS No. 129622-68-0. Molecular formula: C162H254N50O36. Mole weight: 3478.06.
β-Endorphin (bovine, camel, mouse)
β-Endorphin is an endogenous opioid neuropeptide. Uses: Neurotransmitter agents. Synonyms: beta-Endorphin (bovine, camel, mouse); beta-Endorphin (1-31); H-Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-His-Lys-Lys-Gly-Gln-OH. Grades: ≥98%. CAS No. 59887-17-1. Molecular formula: C155H250N42O44S. Mole weight: 3437.96.
BigLEN (mouse)
BigLEN (mouse) is a proSAAS-derived neuropeptide that acts as a GPR171 agonist. It regulates food intake in mice, and suppresses the release of glutamate onto parvocellular neurons of the paraventricular nucleus in a process dependent upon activation of postsynaptic G proteins. CAS No. 501036-69-7. Molecular formula: C78H130N24O22. Mole weight: 1756.03.
Biotinyl-α-CGRP (mouse, rat)
Synonyms: Biotinyl-Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 (Disulfide bridge: Cys2-Cys7). Grades: ≥95% by HPLC. CAS No. 1816258-61-3. Molecular formula: C172H276N52O54S3. Mole weight: 4032.53.
Ces1d, also known as carboxylesterase 1D, is a member of a large family of carboxylesterases that are responsible for the hydrolysis of ester and amide bonds. It is the principle lipase of white adipose tissue fat cake extracts. Partially purified white adipose tissue Ces1d had lipase activity as well as lesser but detectable neutral cholesteryl ester hydrolase activity. The protein shows low catalytic efficiency for hydrolysis of CPT-11, a prodrugs for camptothecin used in cancer therapeutics. Recombinant mouse Ces1d, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. Group: Enzymes. Synonyms: Ces1d; Carboxylesterase 3; FAEE synthase; TGH; Ces3. Purity: > 90% by SDS-PAGE. Esterase. Mole weight: 60.9 kDa. Activity: > 80,000 pmol/min/ug. Storage: Store at +4°C for short term (1-2 weeks). For long term storage, aliquot and store at -70°C. Avoid repeated freeze/thaw cycles. Form: Liquid. Source: Insect cell (Baculovirus) and fused to His-tag at N-terminus. Species: Mouse. Ces1d; Carboxylesterase 3; FAEE synthase; TGH; Ces3; Carboxylesterase 1D. Cat No: NATE-1633.
Cathepsin K from Mouse, recombinant
Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis. Group: Enzymes. Synonyms: CTSK; CTSO; CTSO3; Cathepsin O; Cathepsin O2; Cathepsin X; EC 3.4.22.38. Enzyme Commission Number: EC 3.4.22.38. CAS No. 94716-09-3. Purity: > 90% by SDS-PAGE. Mole weight: 23.4 kDa (115-329 aa). Activity: >1000 mU/mg. Storage: Stable for 6 months at -80°C. Use as provided or dilute to 0.1 mg/ml with 50% glycerol. Aliquot and store at -80°C. Avoid repeated freezing and thawing cycles, as this may lead to the loss in its activity over time. Form: Liquid. Source: E. coli. Species: Mouse. CTSK; CTSO; CTSO3; Cathepsin O; Cathepsin O2; Cathepsin X; EC 3.4.22.38. Cat No: NATE-1704.
Class A CpG oligonucleotide (Mouse specific)
CpG ODNs are synthetic oligonucleotides that contain unmethylated CpG dinucleotides in specific sequence contexts (CpG motifs). These CpG motifs are present at a 20-fold greater frequency in bacterial DNA than in mammalian DNA. CpG ODNs are recognized by Toll-like receptor 9 (TLR9), which leads to strong immunostimulatory effects.ODN 1585 is a class A CpG ODN specific for mouse TLR9. Class A CpG ODNs are characterized by a central, phosphodiester, CpG-containing palindromic motif and a 3'phosphorothioate poly-G string.They induce high IFN-α production from plasmacytoid dendritic cells (pDCs) but are weak stimulators of TLR9-dependent NF-κB signaling. Group: Others. Synonyms: CpG oligonucleotides; ODNs; ODN 1585; CpG ODNs; CpG. Storage: Upon receipt, store at -20 °C. Form: Lyophilized powder. CpG oligonucleotides; ODNs; ODN 1585; CpG ODNs; CpG. Cat No: LIGC-010.
Cortistatin 14 (mouse, rat)
Cortistatin-14 is an endogenous neuropeptide expressed in the cortex and hippocampus. Synonyms: Cortistatin-14; H-PRO-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-SER-SER-CYS-LYS-OH; CST-14; CST-14 (RAT). Grades: 98%. CAS No. 186901-48-4. Molecular formula: C81H113N19O19S2. Mole weight: 1721.01.
CRAMP-18 (mouse)
CRAMP-18 (mouse) corresponds to the functional region of the antimicrobial peptide CRAMP and has strong antibacterial activity against a variety of bacteria, with no hemolytic activity (MIC = 12.5-50 μM). Synonyms: H-Gly-Glu-Lys-Leu-Lys-Lys-Ile-Gly-Gln-Lys-Ile-Lys-Asn-Phe-Phe-Gln-Lys-Leu-OH; glycyl-L-alpha-glutamyl-L-lysyl-L-leucyl-L-lysyl-L-lysyl-L-isoleucyl-glycyl-L-glutaminyl-L-lysyl-L-isoleucyl-L-lysyl-L-asparagyl-L-phenylalanyl-L-phenylalanyl-L-glutaminyl-L-lysyl-L-leucine. Grades: 95%. CAS No. 256639-17-5. Molecular formula: C101H171N27O24. Mole weight: 2147.64.
CRAMP (mouse)
CRAMP (mouse) is an antimicrobial peptide. CRAMP (mouse) can be used for the research of biofilm-associated infections [1]. Uses: Scientific research. Group: Peptides. CAS No. 376364-36-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P4855.
CRAMP (mouse)
This cathelicidin-related antimicrobial peptide (CRAMP) is the sole murine cathelicidin. CRAMP expression in the intestinal tract is restricted to surface epithelial cells in the colon. CRAMP shows antimicrobial activity against the murine enteric pathogen Citrobacter rodentium and destroys skin Candida albicans. Synonyms: H-Gly-Leu-Leu-Arg-Lys-Gly-Gly-Glu-Lys-Ile-Gly-Glu-Lys-Leu-Lys-Lys-Ile-Gly-Gln-Lys-Ile-Lys-Asn-Phe-Phe-Gln-Lys-Leu-Val-Pro-Gln-Pro-Glu-Gln-OH; CRAMP, mouse; CRAMP (mouse) (TFA salt). Grades: ≥95%. CAS No. 376364-36-2. Molecular formula: C178H302N50O46. Mole weight: 3878.60.
(Cys18)-Atrial Natriuretic Factor (4-18) amide (mouse, rabbit, rat) binds with high affinity to about 99% of ANF receptors in isolated rat perfusion kidneys. It competes effectively for binding sites with bioactive atrial peptides but has no agonist or antagonist effect on cGMP generation in cultured vascular smooth muscle and endothelial cells. Synonyms: C-ANF (4-23); H-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Cys-NH2 (Disulfide bridge: Cys4-Cys15); L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanyl-glycyl-glycyl-L-arginyl-L-isoleucyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-glycyl-L-alanyl-L-cysteinamide (4->15)-disulfide; (18-cysteinyl)-ANF (4-23)-NH2; Des(gln18,ser19,gly20,leu21,gly22)-atrial natriuretic peptide fragment 4-23 amide rat. Grades: 95%. CAS No. 111863-73-1. Molecular formula: C64H107N25O19S2. Mole weight: 1594.82.
DFR10_MOUSE Defensin-related cryptdin, related sequence 10 precursor
DFR10_MOUSE Defensin-related cryptdin, related sequence 10 precursor is an antibacterial peptide isolated from Mus musculus. Synonyms: Cys-Pro-Pro-Cys-Pro-Ser-Cys-Pro-Ser-Cys-Pro-Trp-Cys-Pro-Met-Cys-Pro-Arg-Cys-Pro-Ser.
MEF cells serve as feeder cells that support the growth of undifferentiated mouse or human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). MEF cells are isolated from 13.5-day old mouse embryos and should be used at early passages. Before use as feeder cells, MEF cells must be mitotically inactivated by γ-irradiation or mitomycin-C treatment. Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 5Vials. US Biological Life Sciences.
Endothelin 3 is a ligand of the endothelin (ET) receptors and a potent vasoconstrictor. Endothelin 3 increases blood pressure in spontaneously hypertensive and normotensive rats, and promotes migration and adhesion of enteric neural crest cells (ENCCs) to the embryonic gut in mice via interaction with ETB. Uses: Vasoconstrictor. Synonyms: Endothelin 3 (Rat,Human); ET-3 (Rat,Human); H-Cys(1)-Thr-Cys(2)-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys(2)-Val-Tyr-Tyr-Cys(1)-His-Leu-Asp-Ile-Ile-Trp-OH; L-cysteinyl-L-threonyl-L-cysteinyl-L-phenylalanyl-L-threonyl-L-tyrosyl-L-lysyl-L-alpha-aspartyl-L-lysyl-L-alpha-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-tyrosyl-L-cysteinyl-L-histidyl-L-leucyl-L-alpha-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophan (1->15),(3->11)-bis(disulfide). Grades: ≥97% by HPLC. CAS No. 117399-93-6. Molecular formula: C121H168N26O33S4. Mole weight: 2643.04.
Endothelin-3, human, mouse, rabbit, rat TFA
Endothelin-3 is a peptide vasoconstricter and a ligand of the endothelin (ET) receptors ETA and ETB (Kbs = 1.05 and 1.49, respectively). It binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB. Synonyms: Endothelin 3 (Rat,Human) (TFA); ET-3 (Rat,Human) (TFA); H-Cys(1)-Thr-Cys(2)-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys(2)-Val-Tyr-Tyr-Cys(1)-His-Leu-Asp-Ile-Ile-Trp-OH.TFA; L-cysteinyl-L-threonyl-L-cysteinyl-L-phenylalanyl-L-threonyl-L-tyrosyl-L-lysyl-L-alpha-aspartyl-L-lysyl-L-alpha-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-tyrosyl-L-cysteinyl-L-histidyl-L-leucyl-L-alpha-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophan (1->15),(3->11)-bis(disulfide) trifluoroacetic acid; Endothelin-3 (human, rat) trifluoroacetate salt. Grades: ≥95%. Molecular formula: C121H168N26O33S4.C2HF3O2. Mole weight: 2757.07.
Endotrophin (mouse)
Endotrophin, a carboxy-terminal cleavage product of the collagen 6α-3 chain produced and released by adipocytes, is greatly upregulated in malignant tumors of the breast, liver colon and pancreas. Endotrophin provides a link between obesity and aggressive tumor growth and may serve as a sensitive diagnostic marker and effective therapeutic target for designing better treatments for cancer and improving obesity-induced insulin resistance. Synonyms: H-Thr-Glu-Pro-Leu-Phe-Leu-Thr-Lys-Thr-Asp-Ile-Cys-Lys-Leu-Ser-Arg-Asp-Ala-Gly-Thr-Cys-Val-Asp-Phe-Lys-Leu-Leu-Trp-His-Tyr-Asp-Leu-Glu-Ser-Lys-Ser-Cys-Lys-Arg-Phe-Trp-Tyr-Gly-Gly-Cys-Gly-Gly-Asn-Glu-Asn-Arg-Phe-His-Ser-Gln-Glu-Glu-Cys-Glu-Lys-Met-Cys-Ser-Pro-Glu-Leu-Thr-Val-OH (Disulfide bridge: Cys12-Cys62, Cys21-Cys45, Cys37-Cys58, air oxidized). Grades: ≥95%. CAS No. 1678414-54-4. Molecular formula: C345H520N92O106S7. Mole weight: 7876.94.
Enterostatin, human, mouse, rat
Enterostatin, human, mouse, rat is a pentapeptide that reduces fat intake. Synonyms: H-APGPR-OH; L-alanyl-L-prolyl-glycyl-L-prolyl-L-arginine; Procolipase activation peptide; Enterostatin (human,mouse,rat); Enterostatin (human); N2-(1-(N-(1-L-alanyl-L-prolyl)glycyl)-L-prolyl)-L-Arginine. Grades: 95%. CAS No. 117830-79-2. Molecular formula: C21H36N8O6. Mole weight: 496.56.
Enterostatin, human, mouse, rat acetate
Enterostatin, human, mouse, rat is a pentapeptide that reduces fat intake. Molecular formula: C23H40N8O8. Mole weight: 556.61.
Galanin (1-16), mouse, porcine, rat
Galanin (1-16), mouse, porcine, rat is an agonist of the hippocampal galanin receptor with Kd of 3 nM. Synonyms: H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Ile-OH; glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparagyl-L-seryl-L-alanyl-glycyl-L-tyrosyl-L-leucyl-L-leucyl-glycyl-L-prolyl-L-histidyl-L-alanyl-L-isoleucine; Galanin (1-16) (porcine, rat); Galanin Fragment 1-16, porcine, rat. Grades: 95%. CAS No. 125118-77-6. Molecular formula: C78H116N20O21. Mole weight: 1669.88.
Galanin (1-29) (rat, Mouse)
Galanin (1-29) (rat, mouse) is a non-selective galanin receptor agonist (Ki = 0.98, 1.48 and 1.47 nM for GAL1, GAL2 and GAL3, respectively) with anticonvulsant activity. Synonyms: Galanin (mouse, rat). CAS No. 114547-31-8. Molecular formula: C141H211N43O41. Mole weight: 3164.48.
Galanin (rat, mouse) trifluoroacetate salt
Galanin is a 29 amino acid, C-terminally amidated neuropeptide with diverse biological activities. Galanin binds to rat galanin (GAL) receptor subtypes GAL1-3 (IC50s = 0.339, 1.35, and 3.31 nM, respectively) and human GAL1-3 (IC50s = 0.288, 1.62, and 12.3 nM, respectively). Synonyms: GAL (rat, mouse); Galanin (1-29) (rat, mouse). Grades: ≥95%. Molecular formula: C141H211N43O41·xCF3COOH. Mole weight: 3164.45.
GIP (mouse)
GIP (mouse) is a gastrointestinal hormone that is expressed in and secreted from the pancreatic islets and promotes insulin secretion [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Gastric inhibitory polypeptide(mouse); GIP(1-42) (mouse). CAS No. 181591-59-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10735.
Non-carboxylated osteocalcin has been shown to be a bone-specific hormone involved in the regulation of glucose metabolism in which Gla peptide acts as a precursor and transport form. Synonyms: H-Tyr-Leu-Gly-Ala-Ser-Val-Pro-Ser-Pro-Asp-Pro-Leu-Glu-Pro-Thr-Arg-Glu-Gln-Cys-Glu-Leu-Asn-Pro-Ala-Cys-Asp-Glu-Leu-Ser-Asp-Gln-Tyr-Gly-Leu-Lys-Thr-Ala-Tyr-Lys-Arg-Ile-Tyr-Gly-Ile-Thr-Ile-OH (Disulfide bridge: Cys19-Cys25). Grades: ≥95%. CAS No. 1802086-27-6. Molecular formula: C226H351N57O74S2. Mole weight: 5114.75.
Glutathione S-Transferase Alpha 4 (GSTa4) Recombinant, Mouse, Positive Control Loading Buffer. Group: Molecular Biology. Grades: Highly Purified. Pack Sizes: 1x1 vial. US Biological Life Sciences.
Worldwide
Glyceraldehyde-3-phosphate Dehydrogenase from Mouse, Recombinant
Glyceraldehyde-3-phosphate dehydrogenase catalyzes the conversion of glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate as part of glycolysis. It has also been shown to have roles in initiation of apoptosis, transcription activation and the shuttling of ER to Golgi vesicles. Group: Enzymes. Synonyms: G3PD; GAPD; HEL-S-162eP; Glyceraldehyde-3-phosphate dehydrogenase isoform 2. Enzyme Commission Number: EC 1.2.1.12. Purity: > 95% by SDS-PAGE. Glyceraldehyde-3-phosphate Dehydrogenase. Mole weight: 38.2kDa. Activity: > 40 units/mg. Storage: Store at +4°C for short term (1-2 weeks). For long term storage, aliquot and store at -70°C. Avoid repeated freeze/thaw cycles. Form: Liquid. Source: E. coli and fused to His-tag at C-terminus. Species: Mouse. GAPDH; glyceraldehyde-3-phosphate dehydrogenase; G3PD; GAPD; HEL-S-162eP; Glyceraldehyde-3-phosphate dehydrogenase isoform 2; glyceraldehyde-3-P-dehydrogenase. Cat No: NATE-1635.
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