Mouse Enzyme Suppliers USA
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Product | Description | |
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2-Ethyl-3-Hydroxybutyryl Coenzyme A Quick inquiry Where to buy Suppliers range | 2-Ethyl-3-Hydroxybutyryl Coenzyme A is a derivative of Coenzyme A, a cofactor in enzymatic acetyl transfer reactions. 2-Ethyl-3-Hydroxybutyryl Coenzyme A has been used to study Rathke's pouch homeobox (RPX), a novel antierior-restricted homeobox gene progressively activated in prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo. Molecular formula: C27H46N7O18P3S. Mole weight: 881.68. | |
2-Ethyl-3-oxobutyryl Coenzyme A Quick inquiry Where to buy Suppliers range | 2-Ethyl-3-oxobutyryl Coenzyme A is a derivative of Coenzyme A, a cofactor in enzymatic acetyl transfer reactions. 2-Ethyl Crotonyl Coenzyme A has been used to study Rathke's pouch homeobox (RPX), a novel antierior-restricted homeobox gene progressively activated in prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo. Molecular formula: C27H44N7O18P3S. Mole weight: 879.66. | |
2-Ethylbutyryl Coenzyme A Quick inquiry Where to buy Suppliers range | 2-Ethylbutyryl Coenzyme A is a Coenzyme A derivative, a cofactor in enzymatic acetyl transfer reactions. 2-Ethylbutyryl Coenzyme A has been used to study Rathke's pouch homeobox (RPX), a novel antierior-restricted homeobox gene progressively activated in prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo. Molecular formula: C27H46N7O17P3S. Mole weight: 865.68. | |
2-Ethyl Crotonyl Coenzyme A Quick inquiry Where to buy Suppliers range | 2-Ethyl Crotonyl Coenzyme A is a Coenzyme A derivative, a cofactor in enzymatic acetyl transfer reactions. 2-Ethyl Crotonyl Coenzyme A has been used to study Rathke's pouch homeobox (RPX), a novel antierior-restricted homeobox gene progressively activated in prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo. Molecular formula: C27H44N7O17P3S. Mole weight: 863.66. | |
4-Diethylaminobenzaldehyde Quick inquiry Where to buy Suppliers range | DEAB is a potent inhibitor of cytosolic (class 1) aldehyde dehydrogenase (ALDH) enzymes (IC50 values 0.057 μM, 1.2 μM, 3.0 μM, 1.2 μM, 0.16 μM, and 13 μM for inhibition of ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, and ALDH5A1, respectively). DEAB is also an excellent substrate for ALDH3A1, and an irreversible inhibitor of ALDH7A1 (KI value 100 μM). Uses: 4-(diethylamino)benzaldehyde is a mechanism-based inhibitor for human aldehyde dehydrogenase isoenzymes. potent and reversible inhibitor of mouse and human class i aldehyde dehydrogenase. Synonyms: 4-(diethylamino)benzaldehyde. Grades: 99 %. CAS No. 120-21-8. Molecular formula: C11H15NO. Mole weight: 177.24. | |
5-Hydroxymethylcytidine Quick inquiry Where to buy Suppliers range | 5-Hydroxymethylcytosine is a DNA pyrimidine nitrogen base. It is formed from the DNA base cytosine by adding a methyl group and then a hydroxy group. It is important in epigenetics, because the hydroxymethyl group on the cytosine can possibly switch a gene on and off. It was first seen in bacteriophages in 1952.[1][2] However, in 2009 it was found to be abundant in human and mouse brains,[3] as well as in embryonic stem cells.[4] In mammals, it can be generated by oxidation of 5-methylcytosine, a reaction mediated by the Tet family of enzymes. 5-Hydroxymethylcytidine is a product in DNA hydroxymethylation. The concentrations of 5-Hydroxymethylcytidine in the brain were used to study Alzheimers disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 19235-17-7. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
5-L-Isoleucineangiotensin II Quick inquiry Where to buy Suppliers range | 5-L-Isoleucineangiotensin II is an endogenous potent vasoconstrictor peptide typically generated by the removal of two residues from angiotensin I by angiotensin-converting enzyme (ACE) by binding to both the AT1 and the AT2 receptors. Uses: An endogenous potent vasoconstrictor peptide. Synonyms: 5-Isoleucine-angiotensin II; L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine; Angiotensin II human; Human angiotensin II; Hypertensin; H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH; Angiotensin II, 5-L-isoleucine-; Alanine, N-[1-[N-[N-[N-[N-(N2-L-α-aspartyl-L-arginyl)-L-valyl]-L-tyrosyl]-L-isoleucyl]-L-histidyl]-L-prolyl]-3-phenyl-, L-; 5-L-Isoleucine-angiotensin II; L-Phenylalanine, N-[1-[N-[N-[N-[N-(N2-L-α-aspartyl-L-arginyl)-L-valyl]-L-tyrosyl]-L-isoleucyl]-L-histidyl]-L-prolyl]-; [Ile5]-Ang II; [Ile5]-Angiotensin II; Angiotensin 2; Angiotensin II; Angiotensin II (human); Angiotensin II (mouse); Angiotensin II [Ile5]; Asp1-Ile5-angiotensin II; Human angiotensin II; Ileu5-angiotensin II; Isoleucyl5-angiotensin II. Grades: 98%. CAS No. 4474-91-3. Molecular formula: C50H71N13O12. Mole weight: 1046.19. | |
Angiotensin I (human, mouse, rat) Quick inquiry Where to buy Suppliers range | Angiotensin 1 (Human), an endogenous peptide substrate for angiotensin converting enzyme (ACE), is precursor to the vasoconstrictor peptide angiotensin II. Synonyms: Angiotensin 1 Human; H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH; L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucine; Pepsitensin; Proangiotensin; 5-Ile-angiotensin I; 5-L-Isoleucine-angiotensin I. Grades: ≥95%. CAS No. 484-42-4. Molecular formula: C62H89N17O14. Mole weight: 1296.48. | |
Angiotensin I (human, rat, mouse) trifluoroacetate salt Quick inquiry Where to buy Suppliers range | Angiotensin I is formed from angiotensinogen by the action of renin, which is released from the kidney juxtaglomerular cells. Angiotensin I is further cleaved to angiotensin II by angiotensin converting enzyme. Angiotensin is a protein hormone that causes blood vessels to become narrower. It helps to maintain blood pressure and fluid balance in the body. It binds to angiotensin receptors in human myometrium membrane preparations with Kd of 11.2 nM and increases renal vascular resistance in isolated rat kidney with EC50 of 10.5 nM. Grades: ≥95%. Molecular formula: C62H89N17O14·xCF3COOH. Mole weight: 1296.48. | |
AUNP-12 Quick inquiry Where to buy Suppliers range | AUNP-12 is highly effective in antagonizing PD-1 signaling, with desirable in vivo exposure upon subcutaneous dosing. It inhibits tumor growth and metastasis in preclinical models of cancer and is well tolerated with no overt toxicity at any of the tested doses. Soluble epoxide hydrolase (sEH) catalyzes the conversion of EpETrEs to the corresponding dihydroxy eicosatrienoic acids (DiHETrEs) thereby diminishing their activity. AUDA is an inhibitor of sEH exhibiting IC50 of 18 nM for the mouse and IC50 of 69 nM forand human enzymes. Synonyms: Aur-012; Aurigene-012; Aurigene NP-12. Grades: ≥95%. CAS No. 1353563-85-5. Molecular formula: C142H226N40O48. Mole weight: 3261.55. | |
AZ32 Quick inquiry Where to buy Suppliers range | AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with IC50 of <6.2 nM for ATM enzyme and IC50 of 0.31 μM for ATM in cell. AZ32 is tolerated in C57Bl6 and Nude mice dosed orally at 200mg/kg which was efficacious in orthotopic mouse models. AZ32 is the first ATMi with oral bioavailability shown to radiosensitize glioma and improve survival in orthotopic mouse models. It also shows adequate selectivity over ATR and also has high cell permeability. Synonyms: AZ-32; AZ 32; N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide. Grades: ≥98%. CAS No. 2288709-96-4. Molecular formula: C20H16N4O. Mole weight: 328.37. | |
AZD-5904 Quick inquiry Where to buy Suppliers range | AZD-5904 is a potent orally bioavailable MPO inhibitor. It inhibited the isolated MPO enzyme with an IC50 value of 140 nM and was approximately equipotent in assays of rat and mouse MPO enzyme activity. It was used for multiple sclerosis and COPD and has been evaluated in single and multiple dose studies in healthy volunteers. Uses: Azd-5904 was used for multiple sclerosis and copd. Synonyms: AZ1, AZ 1 AZ-1; TX4; TX-4; TX 4; AZD-5904; AZD 5904; AZD5904. (S)-3-((tetrahydrofuran-2-yl)methyl)-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one. Grades: 98%. CAS No. 618913-30-7. Molecular formula: C10H12N4O2S. Mole weight: 252.29. | |
BMN-673 8R,9S Quick inquiry Where to buy Suppliers range | BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP inhibitor BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development. Synonyms: Talazoparib (8R,9S); (8R,9S)-BMN-673; BMN673 (8R,9S); BMN 673 (8R,9S). Grades: >98%. CAS No. 1207456-00-5. Molecular formula: C19H14F2N6O. Mole weight: 380.35. | |
C3bot (154-182) Quick inquiry Where to buy Suppliers range | C3bot (154-182) is a transferase-deficient neurotrophic fragment of clostridial C3 protein. It promotes axonal and dendritic growth and branching of hippocampal neurons at submicromolar concentrations and promotes reinnervation of target tissues in organotypical hippocampal/entorhinal slice cultures. It reduces levels of active neuronal RhoA by a non-enzymatic mechanism and enhances functional recovery and regeneration in a mouse model of spinal cord injury. Synonyms: C3bot (154-182); 1246280-79-4. CAS No. 1246280-79-4. Molecular formula: C137H221N37O40S. Mole weight: 3058.54. | |
CAY10566 Quick inquiry Where to buy Suppliers range | Stearoyl-CoA desaturase (SCD) is an endoplasmic reticulum enzyme that catalyzes the rate-limiting step in the formation of monounsaturated fatty acids (MUFAs), specifically oleate and palmitoleate from stearoyl-CoA and palmitoyl-CoA. CAY10566 is a potent and selective inhibitor with IC50s of 4.5 and 26 nM in mouse and human enzymatic assays, respectively. It also shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells. Synonyms: CAY 10566; CAY-10566. Grades: ≥98%. CAS No. 944808-88-2. Molecular formula: C18H17ClFN5O2. Mole weight: 389.8. | |
CAY10640 Quick inquiry Where to buy Suppliers range | Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that in humans is encoded by the EPHX2 gene. sEH is a member of the epoxide hydrolase family. CAY10640 is a 1-aryl-3-(1-acylpiperidin-4-yl)urea analog that inhibits recombinant human and mouse sEH with IC50 values both equal to 0.4 nM. Synonyms: sEHi; Soluble Epoxide Hydrolase Inhibitor; CAY 10640; CAY-10640. Grades: ≥98%. CAS No. 1208549-68-1. Molecular formula: C17H20F3N3O3. Mole weight: 371.4. | |
CUDA Quick inquiry Where to buy Suppliers range | CUDA is an inhibitor of soluble epoxide hydrolase (sEH) which catalyzes the conversion of EETs to the corresponding dihydroxy eicosatrienoic acids (DiHETrEs; DHETs) thereby diminishing their activity with IC50 values of 11.1 nM and 112 nM for the mouse and human enzymes, respectively. Synonyms: 12-[[(cyclohexylamino)carbonyl]amino]-dodecanoic acid. Grades: ≥95%. CAS No. 479413-68-8. Molecular formula: C19H36N2O3. Mole weight: 340.5. | |
Cystamine dihydrochloride Quick inquiry Where to buy Suppliers range | Cystamine dihydrochloride is the dihydrochloride salt of cystamine, which is an organic disulfide that inhibits tissue transglutaminase (TGM2) with an IC50 value of approximately 2.5 mM. It is orally available, and decreases aggregated and cross-linked huntingtin in transfected cells. It is neuroprotective in mouse models of Huntington's disease. It has exhibited suppressive effects against HIV replication in infected human cells. It could extend survival and improve motor performance in transgenic HD mice. It inhibits caspase 3, increases intracellular glutathione, and reduces inflammation in a rat model of inflammatory bowel disease. Uses: Enzyme inhibitors. Synonyms: 2-(2-aminoethyldisulfanyl)ethanamine; dihydrochloride. Grades: > 97 %. CAS No. 56-17-7. Molecular formula: C4H14Cl2N2S2. Mole weight: 225.20. | |
Diflapolin Quick inquiry Where to buy Suppliers range | Diflapolin is a dual inhibitor of 5-lipoxygenase-activating protein (FLAP) and soluble epoxide hydrolase (sEH). It is selective for FLAP and sEH over other arachidonic acid metabolism enzymes. Diflapolin (1, 3, and 10 mg/kg) decreases inflammation in a mouse model of peritonitis induced by zymosan, reducing the production of LTB4 and LTC4 and inhibiting leukocyte recruitment. Grades: ≥98%. CAS No. 724453-98-9. Molecular formula: C22H17Cl2N3O2S. Mole weight: 458.36. | |
DUB Inhibitor IV, b-AP15 (NSC687852, 3, 5-bis ( (4-Nitrophenyl) methylidene) -1-prop-2-enoylpiperidin-4-one, (3E, 5E) -1-Acryloyl-3, 5-bis (4-nitrobenzylidene) piperidin-4-one, USP14 Inhibitor III, UCH-L5/UCH37 Inhibitor II) Quick inquiry Where to buy Suppliers range | A cell-permeable bis-nitrobenzylidene-piperidinone compound that acts as a potent, reversible and selective inhibitor of 19S regulatory-particle-associated deubiquitylating enzymes (DUBs) UCH-L5 and USP-14 (IC50=2.1uM against Ub-AMC substrate), with no effect on UCH-L1, UCH-L3, USP2, USP7, USP8 and BAP1 and on the proteasomal proteolytic activities. Shown to prevent proteasomal degradation (IC50=0.8uM in MelJuSo-UbG76V-YFP cells), and cause accumulation of higher molecular weights polyubiquitinated proteins in HCT-116 cells. Preferentially induces cell-cycle arrest and apoptosis in several colon cancer and in CNS cells, and effectively suppresses tumor growth in various mouse model (5mg/kg, i.p.). Group: Biochemicals. Grades: Highly Purified. CAS No. 1009817-63-4. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?, Molecular Weight: 419.4. US Biological Life Sciences. | Worldwide |
Elacridar Quick inquiry Where to buy Suppliers range | Elacridar hydrochloride (GF120918A) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. In vitro, GF120918A demonstrated high plasma protein binding across species, although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse, rat, and dog plasma. GF120918A did not demonstrate potent inhibition of several human cytochrome P450 enzymes evaluated in vitro, with IC(50) values well above concentrations anticipated to be achieved in vivo. Together, these data confirm the utility of GF120918A as a tool P-glycoprotein inhibitor in preclinical species and offer additional guidance on preclinical dose regimens likely to produce P-glycoprotein-mediated effects. Synonyms: GF120918; GF-120918; GF 120918; GF-120918A; GF120918A; GF 120918A; GG 918; D03968. Elacridar hydrochloride. CAS No. 143664-11-3. Molecular formula: C34H33N3O5. Mole weight: 563.654. | |
Emodin Quick inquiry Where to buy Suppliers range | Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice. Group: Biobased Products. Alternative Names: 1,3,8-trihydroxy-6-methylanthraqunone. Grades: 98%. CAS No. 518-82-1. Product ID: BBC518821. Molecular formula: C15H10O5. Mole weight: 270.24. IUPAC Name: 1,3,8-Trihydroxy-6-methylanthracene-9,10-dione. Appearance: Powder. Density: 1.33 g/ml. SMILES: CC1=CC2=C (C (=C1)O)C (=O)C3=C (C2=O)C=C (C=C3O)O. | |
ERO1 Inhibitor II, EN460 Quick inquiry Where to buy Suppliers range | A cell-permeable thiol reactive enone (EN) compound that selectively interacts with the active-site cysteine of reduced, active form of ERO1alpha and inhibits its activity (IC50 = 1.9uM). Also prevents ERO1 re-oxidation both in vitro and in mouse embryonic fibroblasts. Activates the unfolded protein response and protects ER-stressed 293T cells. Can inhibit ERO1alpha even in the presence of an excess amount of competing thiols. Can inhibit ERO1alpha even in the presence of an excess amount of competing thiols. EN460 binding to ERO1alpha is shown to promote the loss of flavin adenine dinucleotide (FAD) from the holoenzyme. Its inhibitory action appears to be irreversible, however addition of FAD and tris (hydroxypropyl) phosphine can restore some enzyme activity. Group: Biochemicals. Alternative Names: (Z)-2-Chloro-5-(4,5-dihydro-5-oxo-4-((5-phenyl-2-furanyl)methylene)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzoic Acid, (Z)-2-Chloro-5-(5-oxo-4-((5-phenylfuran-2-yl)methylene)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)benzoic Acid. Grades: Highly Purified. CAS No. 496807-64-8. Pack Sizes: 25mg. Molecular Formula: C??H??ClF?N?O?, Molecular Weight: 460.8. US Biological Life Sciences. | Worldwide |
Ethonafide Quick inquiry Where to buy Suppliers range | Ethonafide is an anthracene-containing derivative of amonafide that belongs to the azonafide series of anticancer agents. The lack of cross-resistance in multidrug-resistant cancer cell lines and the absence of a quinone and hydroquinone moiety make ethonafide a potentially less cardiotoxic replacement for existing anthracene-containing anticancer agents. Ethonafide was cytotoxic against three human prostate cancer cell lines at nanomolar concentrations. Ethonafide was found to be better tolerated and more effective at inhibiting tumor growth compared with mitoxantrone in a human xenograft tumor regression mouse model. Mechanistically, we found that ethonafide inhibited topoisomerase II activity by stabilizing the enzyme-DNA complex, involving both topoisomerase IIalpha and -beta. In addition, ethonafide induced a potent G(2) cell cycle arrest in the DU 145 human prostate cancer cell line. By creating stable cell lines with decreased expression of topoisomerase IIalpha or -beta, we found that a decrease in topoisomerase IIalpha protein expression renders the cell line resistant to ethonafide. The decrease in sensitivity to ethonafide was associated with a decrease in DNA damage and an increase in DNA repair as measured by the neutral comet assay. These data demonstrate that ethonafide is a topoisomerase II poison and that it is topoisomerase IIalpha-specific in the DU 145 human prostate cancer cell line. Uses: Topoisomerase ii inhibitors. Synonyms: AMP-53; AMP 53; AMP53; 2-(2'-(Dimethylamino)ethyl)-1,2-dihydro-7-ethoxydibenz(de, H)isoquinoline-1,3-dione; 2-[2-(Dimethylamino)ethyl]-7-ethoxy-1H-dibenz[de,h]isoquinoline-1,3(2H)-dione. CAS No. 175293-23-9. Molecular formula: C22H22N2O3. Mole weight: 362.43. | |
Gp100 (25-33), mouse Quick inquiry Where to buy Suppliers range | Gp100 (25-33), mouse sequence is found in residues 25 to 33 of the mouse self/tumor antigen glycoprotein (mgp100). Mgp100 is an enzyme involved in pigment synthesis, and the epitope fragment is expressed in both normal melanocytes and melanoma cells. Uses: Peptide Inhibitors. CAS No. 212370-36-0. Product ID: R1928. | |
GSK 1562590 hydrochloride Quick inquiry Where to buy Suppliers range | GSK 1562590 hydrochloride is a high affinity and selective urotensin II (UT) receptor antagonist (pKi = 9.14, 9.28, 9.34, 9.64 and 9.66 at monkey, human, mouse, cat and rat recombinant receptors, respectively). It displays selectivity for UT receptors over a range of GPCRs, ion channels, enzymes and neurotransmitter transporters. GSK 1562590 has been shown to inhibit human urotensin-II (hU-II)-induced contraction of isolated rat aorta in vitro and ex vivo. Synonyms: GSK 1562590 hydrochloride; GSK1562590 hydrochloride; GSK-1562590 hydrochloride; N-[(1R)-1-[3'-(Aminocarbonyl)[1,1'-biphenyl]-4-yl]-2-(1-pyrrolidinyl)ethyl]-6,7-dichloro-2,3-dihydro-N-methyl-3-oxo-4H-1,4-benzoxazine-4-acetamide hydrochloride; 3-[4-[(1R)-1-[[2-(6,7-dichloro-3-oxo-1,4-benzoxazin-4-yl)acetyl]-methylamino]-2-pyrrolidin-1-ylethyl]phenyl]benzamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1003878-07-6. Molecular formula: C30H30Cl2N4O4.HCl. Mole weight: 617.95. | |
H-Phg(4-OH)-OH Quick inquiry Where to buy Suppliers range | A carnitine palmitoyltransferase-1 inhibitor. It has been shown to improve whole-body glucose tolerance and insulin sensitivity in high-fat diet-induced obese mouse with insulin resistance. Uses: Enzyme inhibitors. Synonyms: Oxfenicine; 4-Hydroxy-L-phenylglycine; L-4-Hydroxyphenylglycine; (2S)-2-amino-2-(4-hydroxyphenyl)acetic acid. Grades: ≥98%. CAS No. 32462-30-9. Molecular formula: C8H9NO3. Mole weight: 167.16. | |
Ibrutinib, Free Base Quick inquiry Where to buy Suppliers range | Ibrutinib, also known as PCI-32765, is a selective and irreversible inhibitor of the enzyme Bruton's tyrosine kinase (BTK). It inhibited BTK potently, with an IC50 of 0.72 nM in enzymology assays and with an IC50 of 10 nM in cellular assay with Ramos cells. It demonstrated preference toward BTK over closely related kinases, blocked B cell function and BTK-dependent processes, and demonstrated clear efficacy in a mouse arthritis model. Young P.R., et al. "Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase." ChemMedChem. 2: 58-61 (2007). Group: Biochemicals. Alternative Names: 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one; PCI 32765; PCI 32765-00; CRA 032765; (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one; Imbruvica. Grades: Purified. CAS No. 936563-96-1. Pack Sizes: 5mg, 25mg, 50mg. US Biological Life Sciences. | Worldwide |
Jojoba Protein HP, Hydrolyzed Quick inquiry Where to buy Suppliers range | Hydrolyzed (fragmented) proteins enzymatically extracted from the jojoba plant, 100% natural, MW 1800-2400 kD. Precipitations of proteins in the bottom of the container is normal. Uses: Lotions, creams, sun care products & after sun products, hair shampoos, leave-in-conditioners, hair mousse, shower gels, makeup products (mascara, foundations). Group: Skin Actives. CAS No. 100684-35-3 / 7732-18-5 / 122-99-6 / 24634-61-5. Product ID: ACM100684353. Appearance: Dark brown, cloudy, faint odor. | |
KT182 Quick inquiry Where to buy Suppliers range | KT182 is a potent inhibitor of α/β-hydrolase domain-containing protein 6 (ABHD6). ABHD6 is a transmembrane serine hydrolase hydrolyzing transmembrane serine hydrolase in nernous system. ABHD6 inhibition was shown to decrease seizure incidence in several mouse models of epilepsy, suggesting its potential for Dravet Syndrome treatment. Uses: Enzyme inhibitors. Synonyms: [4-[4-[3-(hydroxymethyl)phenyl]phenyl]triazol-1-yl]-(2-phenylpiperidin-1-yl)methanone. Grades: ≥98%. CAS No. 1402612-62-7. Molecular formula: C27H26N4O2. Mole weight: 438.5. | |
Methysticin Quick inquiry Where to buy Suppliers range | Methysticin is a natural kavalactone found in the kava plant. It induces hepatic CYP1A1 enzyme. Study in a mouse model of Alzheimer's disease has shown that methysticin activated the Nrf2 pathway and improved cognitive ability. Synonyms: 2H-Pyran-2-one, 6-[(1E)-2-(1,3-benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-, (6R)-; (6R)-6-[(1E)-2-(1,3-Benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one; 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-[3,4-(methylenedioxy)styryl]-, (R)-; 2H-Pyran-2-one, 6-[2-(1,3-benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-, [R-(E)]-; (+)-Methysticin; d-Methysticin; Kavahin; Kavatin; Methysticin; NSC 112158. Grades: ≥98%. CAS No. 495-85-2. Molecular formula: C15H14O5. Mole weight: 274.27. | |
Mf-63 Quick inquiry Where to buy Suppliers range | Mf-63 is a selective Microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. Its IC50 value is 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively. It displays greater than 1,000-fold selectivity over other prostanoid synthases. It strongly inhibited guinea pig mPGES-1 but not the mouse or rat enzyme in rodent species. It did not cause NSAID-like gastrointestinal toxic effects that is caused by non-selective COX inhibitors, although it markedly suppresses PGE2 synthesis in the stomach. It prevents LPS-induced hyperglasia. It has anti-inflammatory, analgesic and anti-cancer agent. Uses: Mf-63 has anti-inflammatory, analgesic and anti-cancer agent. Synonyms: 2-(9-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-benzenedicarbonitrile;2-(6-chloro-1H-phenanthro-[9,10-d]iMidazol-2-yl)isophthalonitrile;MF-63; MF63; MF 63. Grades: >98%. CAS No. 892549-43-8. Molecular formula: C23H11ClN4. Mole weight: 378.81. | |
Myriocin (Thermozymocidin, ISP) Quick inquiry Where to buy Suppliers range | Myriocin is an a-amino fatty acid derived from species of several genera of fungi, notably Myriococcum, Melanconis and Isaria. Myriocin is a potent inhibitor of sphingosine biosynthesis by blocking the first enzyme in the pathway, serine palmitoyltransferase. Myriocin induces apoptosis by depletion of cellular sphingolipids, inhibits proliferation of IL-2-dependent mouse cytotoxic cells and is a potent immunosuppressant. Group: Biochemicals. Grades: Highly Purified. CAS No. 35891-70-4. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
Oxidized ATP (oATP, Purinergic Receptor Antagonist, Oxidized ATP, Purinergic Receptor P2X7 Antagonist, Oxidized ATP, Purinergic Receptor Inhibitor, Oxidized ATP, O-ATP) Quick inquiry Where to buy Suppliers range | A 2,3-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X7 purinergic receptors in J774 mouse macrophages. Does not affect P2g receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca2+ influx in lymphocytes (100uM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts. Group: Biochemicals. Grades: Highly Purified. CAS No. 71997-40-5. Pack Sizes: 25mg. Molecular Formula: C??H??N?O??P?. US Biological Life Sciences. | Worldwide |
Oxyntomodulin (human, mouse, rat) Quick inquiry Where to buy Suppliers range | Oxyntomodulin (human, mouse, rat) can effectively inhibit gastric acid secretion and pancreatic enzyme secretion when infused iv. Furthermore, Oxyntomodulin injection into the intraventricular and hypothalamic paraventricular nucleus effectively and consistently inhibits food intake in both fasted and non-fasted animals. Synonyms: OXM (human, mouse, rat); H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-Lys-Arg-Asn-Arg-Asn-Asn-Ile-Ala-OH; Preproglucagon (53-89) (human, mouse, rat); Proglucagon (33-69) (human, mouse, rat); Glucagon-37 (human, mouse, rat); L-histidyl-L-seryl-L-glutaminyl-glycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparagyl-L-threonyl-L-lysyl-L-arginyl-L-asparagyl-L-arginyl-L-asparagyl-L-asparagyl-L-isoleucyl-L-alanine. Grades: 95%. CAS No. 159002-68-3. Molecular formula: C192H295N61O60S. Mole weight: 4449.83. | |
PF-06840003 Quick inquiry Where to buy Suppliers range | PF-06840003 is a highly selective inhibitor of IDO1 (IC50 = 0.41mcM), an immunosuppressive enzyme induced by multiple cancers. Study in vitro showed that PF-06840003 led to IDO-1-induced T-cell anergy. Study in vivo revealed that it significantly suppressed tumor growth in combination with avelumab in mouse model. Uses: Antitumor drug. Synonyms: EOS200271, EOS-200271; EOS 200271; PF-06840003; PF 06840003; PF06840003. CAS No. 198474-05-4. Molecular formula: C12H9FN2O2. Mole weight: 232.21. | |
PF-1355 Quick inquiry Where to buy Suppliers range | PF-1355 is a selective, mechanism-based inhibitor of myeloperoxidase (MPO) (IC50 = 1.5 μM in LPS-stimulated human whole blood) with excellent selectivity for MPO without disrupting a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. PF-1355 was used to test the hypothesis that MPO activity is a critical mediator of disease activity in immune complex vasculitis mouse models, and to support the confidence in rationale for this mechanism as a therapeutic approach to treat related human condition such as alleviating tissue injury caused by Goodpasture syndrome and pulmonary vasculitis induced by immune complexes. Synonyms: 2-(6-(2,5-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide;PF-06281355; PF 06281355; PF06281355; PF-1355; PF 1355; PF1355. CAS No. 1435467-38-1. Molecular formula: C14H15N3O4S. Mole weight: 321.35. | |
Posaconazole Quick inquiry Where to buy Suppliers range | Anti-fungal agent; sterol α-demethylase inhibitor. Posaconazole is a highly potent broadspectrum antifungal drug. It blocks the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase resulting in accumulation of methylated sterol precursors. In contrast to other antifungal azoles, posaconazole has been reported not to induce the efflux pump mechanism. Posaconazole was able to produce a parasitological cure in a mouse model of the chronic stage of Chagas disease. Group: Biochemicals. Alternative Names: 2, 5-Anhydro-1, 3, 4-trideoxy-2-C- (2, 4-difluorophenyl) -4- [ [4- [4- [4- [1- [ (1S, 2S) -1-ethyl-2-hydroxypropyl] -1, 5-dihydro-5-oxo-4H-1, 2, 4-triazol-4-yl] phenyl] -1-piperazinyl] phenoxy] methyl] -1- (1H-1, 2, 4-triazol-1-yl) -D-threo-pentitol; Noxafil; Sch 56592. Grades: Highly Purified. CAS No. 171228-49-2. Pack Sizes: 250mg, 500mg, 1g, 5g. Molecular Formula: C??H??F?N?O?, Molecular Weight: 700.78. US Biological Life Sciences. | Worldwide |
PRL-3 Inhibitor (BR-1, P0108, Phosphatase of Regenerating Liver 3 Inhibitor, PTP4A3 Inhibitor) Quick inquiry Where to buy Suppliers range | Phosphatase of regenerating liver 3 (PRL-3, also known as PTP4A3) plays critical roles in cell proliferation, motility, and invasion, and thus contributes to cancer metastasis. PRL-3 inhibitor is a cell-permeable benzylidene rhodamine that inhibits PRL-3 (IC50=900nM for human PRL-3 in vitro), with minimal activity against other phosphatases. It reduces the invasion of mouse melanoma B16F10 cells in a cell-based assay. PRL-3 inhibitor has been used to elucidate the actions of this enzyme, demonstrating that it dephosphorylates Tyr783 on integrin beta1 and modulates VEGF-mediated endothelial cell migration. It dose-dependently inhibits the growth and triggers apoptosis in cancer cell lines. Group: Biochemicals. Alternative Names: 5-[[5-bromo-2-[(2-bromophenyl) methoxy] phenyl] methylene] -2- thioxo-4-thiazolidinone. Grades: Highly Purified. CAS No. 893449-38-2. Pack Sizes: 1mg, 5mg, 10mg, 25mg. Molecular Formula: C17H11Br2NO2S2. US Biological Life Sciences. | Worldwide |
PYZD-4409 Quick inquiry Where to buy Suppliers range | PYZD-4409 is an inhibitor of ubiquitin-activating enzyme UBA1 (E1). PYZD-4409 induced cell death in malignant cells and preferentially inhibited the clonogenic growth of primary acute myeloid leukemia cells compared with normal hematopoietic cells. Mechanistically, genetic or chemical inhibition of E1 increased expression of E1 stress markers. Moreover, BI-1 overexpression blocked cell death after E1 inhibition, suggesting ER stress is functionally important for cell death after E1 inhibition. Finally, in a mouse model of leukemia, intraperitoneal administration of PYZD-4409 decreased tumor weight and volume compared with control without untoward toxicity. Thus, our work highlights the E1 enzyme as a novel target for the treatment of hematologic malignancies. Synonyms: PYZD-4409; PYZD 4409; PYZD4409. Grades: 0.98. CAS No. 423148-78-1. Molecular formula: C14H7ClFN3O5. Mole weight: 351.674. | |
Qc 1 Quick inquiry Where to buy Suppliers range | Qc 1 is a reversible, non-competitive inhibitor of threonine dehydrogenase (TDH) (IC50 ~500 nM), with no detectable inhibition of other dehydroxygenase enzymes at concentrations up to 10 mM. It induces autophagy and inhibits cell proliferation in mouse embryonic stem (ES) cells. Synonyms: Qc1; Qc-1; Qc 1; 1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide; Qc1; Qc-1; Qc 1. Grades: ≥98% by HPLC. CAS No. 403718-45-6. Molecular formula: C23H16F3N3O2S. Mole weight: 455.45. | |
Ribavirin Quick inquiry Where to buy Suppliers range | Ribavirin is a nucleoside analog that inhibits the replication of both DNA and RNA viruses, including influenza type A and type B. Ribavirin, as ribavirin 5-phosphate, affects virus-infected cells primarily by inhibiting the enzyme inosine 5-monophosphate (IMP) dehydrogenase. It potently suppresses eIF4E-mediated oncogenic transformation of murine cells in vitro, of tumor growth of a mouse model of eIF4E-dependent human squamous cell carcinoma in vivo, and of colony formation of eIF4E-dependent acute myelogenous leukemia cells derived from human patients. Group: Biochemicals. Alternative Names: 1-ß-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide, ICN-1229, Rebetol, Viramid, Virazid, Virazole. Grades: Highly Purified. CAS No. 36791-04-5. Pack Sizes: 10g, 25g, 50g, 100g, 250g. Molecular Formula: C8H12N4O5, Molecular Weight: 244.2. US Biological Life Sciences. | Worldwide |
RN983 Quick inquiry Where to buy Suppliers range | RN983 is a selective BTK enzyme inhibitor. It inhibits IgG production in B-cells with an IC50 value of 2.5?±?0.7?nM and PGD2 production from mast cells with an IC50 value of 8.3?±?1.1?nM. RN983 showed similar activities in the allergic mouse model of asthma. RN983 may be effective as a stand-alone asthma therapy or used in combination with inhaled steroids and β-agonists in severe asthmatics. Uses: Asthma. Synonyms: RN983; RN-983; RN 983. 6-(tert-butyl)-8-fluoro-2-(3-(hydroxymethyl)-4-(1-methyl-5-((5-(1-methylpiperidin-4-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydropyridazin-3-yl)pyridin-2-yl)phthalazin-1(2H)-one. Grades: 98%. CAS No. 1423129-83-2. Molecular formula: C34H37FN8O3. Mole weight: 624.72. | |
S14-95 Quick inquiry Where to buy Suppliers range | S14-95 is an inhibitor of the JAK/STAT pathway isolated from Penicillium sp. 14-95. It inhibits the IFN-gamma mediated expression of the reporter gene with IC50 values of 2.5 to approximately 5 mg/ml. It inhibits the expression of the proinflammatory enzymes COX-2 and NOS II at 5 microg/ml (10.8 mM) in LPS/IFN-gamma stimulated J774 mouse macrophages. Molecular formula: C28H34O5. Mole weight: 450.57. | |
Talazoparib Quick inquiry Where to buy Suppliers range | Talazoparib, also known as BMN-673, is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development. Uses: For research used only. Synonyms: BMN-673; LT-673. BMN 673; LT 673. BMN673; LT673. Grades: 98%. CAS No. 1207456-01-6. Molecular formula: C19H14F2N6O. Mole weight: 380.359. | |
TDSP5 Quick inquiry Where to buy Suppliers range | TDSP5, a low molecular weight protamine as a nontoxic heparin/low molecular weight heparin antidote, is a homogeneous 1880-d peptide fragment derived directly from protamine by enzymatic digestion of protamine with thermolysin. TDSP5 neutralizes the anticoagulant effects of heparin and commercial low molecular-weight heparin preparations. TDSP5 shows significantly reduced crossreactivity toward mouse sera containing antiprotamine antibodies. TDSP5 exhibits a decrease in its potential in activating the complement system. Synonyms: LMWP-TDSP5; Low molecular weight protamine-TDSP5. | |
Telaprevir Quick inquiry Where to buy Suppliers range | Telaprevir is a potent, selective, peptidomimetic inhibitor of the hepatitis C virus (HCV) NS3-4A serine protease, and it demonstrated excellent antiviral activity both in genotype 1b HCV replicon cells (50% inhibitory concentration [IC50] = 354 nM) and in human fetal hepatocytes infected with genotype 1a HCV-positive patient sera (IC50 = 280 nM). Telaprevir forms a covalent but reversible complex with the genotype 1a HCV NS3-4A protease in a slow-on, slow-off process with a steady-state inhibition constant (K(I)*) of 7 nM. Dissociation of the covalent enzyme-inhibitor complex of Telaprevir and genotype 1a HCV protease has a half-life of almost an hour. A >4-log10 reduction in the HCV RNA levels was observed after a 2-week incubation of replicon cells with Telaprevir, with no rebound of viral RNA observed after withdrawal of the inhibitor. In several animal species, Telaprevir exhibits a favorable pharmacokinetic profile with high exposure in the liver. In a recently developed HCV protease mouse model, Telaprevir showed excellent inhibition of HCV NS3-4A protease activity in the liver. Uses: Oligopeptides. Synonyms: Telavic; VRT 111950; VX 950; Incivek; Incivo; LY 570310; MP 424; S-Telaprevir; (1S, 3aR, 6aS) - (2S) -2-Cyclohexyl-N- (2-pyrazinylcarbonyl) glycyl-3-methyl-L-valyl-N- [ (1S) -1- [2- (cyclopropylamino) -2-oxoacetyl]butyl]octahydrocyclopenta [c]pyrrole-1-carboxamide. Grades: ≥98% (HPLC). CAS No. 402957-28-2. Molecular formula: C36H53N7O6. Mole weight: 679.85. | |
URB754 Quick inquiry Where to buy Suppliers range | URB754 is a potent and non-competitive inhibitor of monoacylglycerol lipase (MAGL) with IC50 value of 200 nM for the recombinant rat brain enzyme. However, it does not inhibit human recombinant, rat brain, or mouse brain MAGL at concentrations up to 100 μM. The MAGL inhibitory activity of URB754 was reported to be attributed to the impurity bis(methylthio)mercurane (IC50 = 11.9 nM for rat recombinant MAGL) that is found in commercial samples. Synonyms: URB-754; URB 754; 6-methyl-2-(4-methylanilino)-3,1-benzoxazin-4-one. Grades: >98%. CAS No. 86672-58-4. Molecular formula: C16H14N2O2. Mole weight: 266.3. | |
Varespladib Quick inquiry Where to buy Suppliers range | Varespladib is a potent and selective inhibitor of secretory phospholipase A2 (sPLA2). The compound Varespladib inhibits both human and mouse sPLA2 group IIA, V, and X enzymes at low nM concentrations. Synonyms: LY315920; LY-315920; LY 315920; A-002; A002; A 002; Varespladib. Grades: >98%. CAS No. 172732-68-2. Molecular formula: C21H20N2O5. Mole weight: 380.39. |