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| Product | Description | |
|---|---|---|
| 2'-Amino-2'-deoxyguanosine-5'-triphospate tetralithium salt | 2'-Amino-2'-deoxyguanosine-5'-triphosphate tetralithium salt, a compound of utmost importance in the realm of biomedical research and drug discovery, exhibits its significance as a precursor for the synthesis of altered nucleotides, particularly employed in DNA and RNA sequencing. Its indispensable role in elucidating DNA methylation, epigenetic modifications, and mutagenesis studies across diverse ailments, encompassing cancer and genetic disorders, renders it a critical component. Synonyms: 2'-Amino-2'-deoxy-D-guanosine-5'-triphospate tetralithium salt. Grades: 95%. CAS No. 108269-13-2. Molecular formula: C10H17N6O13P3Li4. Mole weight: 549.96. |  |
| 2-Amino-2'-deoxy-N-methoxyadenosine-13C,15N2 | 2-Amino-2'-deoxy-N-methoxyadenosine-13C,15N2, is an intermediate in the synthesis of 8-Oxo-2-deoxyguanosine-13C,15N2 (O850252). A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C1013CH16N415N2O4, Molecular Weight: 299.26. US Biological Life Sciences. |  Worldwide |
| 2-Aminofluorene | 2-Aminofluorene is a synthetic chemical insecticide. 2-Aminofluorene is a genotoxin. 2-Aminofluorene can be used in the research of DNA adduct structure, DNA repair, carcinogenesis, and mutagenesis [1] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 153-78-6. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W016433. |  |
| 2'-Bromo-2'-deoxyuridine | 2'-Bromo-2'-deoxyuridine is a chemical compound commonly used in biomedical research. It acts as a thymidine analog, incorporating into DNA during replication and inhibiting cell proliferation. This compound is particularly useful in studying DNA synthesis, cell cycle progression, and mutagenesis. It is also utilized in the research of viral infections and certain cancers due to its antiviral and antineoplastic properties. Synonyms: 2'-Bromo-2'-deoxy-D-uridine; 1-((2R,3R,4R,5R)-3-bromo-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 1-(2-Bromo-2-deoxy-beta-D-xylofuranosyl)uracil; 1-(2-Bromo-2-deoxypentofuranosyl)-4-hydroxypyrimidin-2(1H)-one. Grades: ≥95%. CAS No. 4753-02-0. Molecular formula: C9H11BrN2O5. Mole weight: 307.10. | |
| 2'-Deoxy-2'-fluoroadenosine 5'-Triphosphate | 2'-Deoxy-2'-fluoroadenosine 5'-Triphosphate: A highly significant and invaluable modified nucleotide employed extensively in the fields of biochemistry and molecular biology for groundbreaking research purposes. Renowned for its pivotal role in the exploration of DNA replication, transcription, and translation mechanisms, this extraordinary compound serves as an indispensable tool. Its application spans across multifaceted investigations pertaining to drug resistance mechanisms, mutagenesis, and groundbreaking advancements in cancer research. Synonyms: (((2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl)methyl)triphosphoric acid; Adenosine 5'-(tetrahydrogen triphosphate), 2'-deoxy-2'-fluoro-; 2'-Fluoro-2'-deoxyadenosine-5'-triphosphate; 2'-Deoxy-2'-fluoroadenosine 5'-(tetrahydrogen triphosphate); 2'-FdATP. Grades: ≥95% by HPLC. CAS No. 73449-07-7. Molecular formula: C10H15FN5O12P3. Mole weight: 509.17. | |
| 2'-Deoxy-2'-fluorouridine-5'-triphosphate tetralithium salt | 2'-Deoxy-2'-fluorouridine-5'-triphosphate tetralithium salt is a vital compound in biomedicine used for various research purposes. It serves as a nucleotide analog that incorporates into DNA during synthesis, aiding in the study of DNA replication, repair, and mutagenesis. This compound can also be utilized in the development of antiviral drugs targeting RNA viruses such as hepatitis C and HIV. Synonyms: 2'-Fluoro-2'-deoxyuridine-5'-triphosphate. Grades: 95%. Molecular formula: C9H11FN2O14P3Li4. Mole weight: 510.87 (free acid). | |
| 2'-Deoxy-5-hydroxymethyluridine-5'-triphosphate triethylammonium salt | 2'-Deoxy-5-hydroxymethyluridine-5'-triphosphate triethylammonium salt is an indispensable recompound employed in biomedical research across diverse applications, functioning as a fundamental constituent for the enzymatic synthesis of altered DNA molecules. It simultaneously serving as a DNA polymerase substrate enabling PCR amplification. This product assuming a pivotal role in comprehending and manipulating DNA's intricate structure and functionality, thereby expediting investigations concerning genetic disorders, mutagenesis, and the advancement of therapeutic pharmaceuticals. Synonyms: Hydroxymethyldeoxyuridine triphosphate. Grades: ≥ 90%. Molecular formula: C10H13N2O15P3·4C6H16N. Mole weight: 902.93. | |
| 2'-Deoxy-5-methyl-isocytidine triphosphate | 2'-Deoxy-5-methyl-isocytidine triphosphate, a paramount substance in the realm of biomedical research, serves as an indispensable component for synthesizing intricate DNA and RNA molecules. Its significance lies in its role as a substrate for DNA polymerases, thereby assuming a pivotal position in an array of molecular biology methodologies encompassing PCR, DNA sequencing, and mutagenesis investigations. Synonyms: 4(1H)-Pyrimidinone, 2-amino-1-[2-deoxy-5-O-[hydroxy[[hydroxy (phosphonooxy) phosphinyl]oxy]phosphinyl]-β -D-erythro-pentofuranosyl]-5-methyl-; 2-Amino-1-[2-deoxy-5-O-[hydroxy[[hydroxy (phosphonooxy) phosphinyl]oxy]phosphinyl]-β -D-erythro-pentofuranosyl]-5-methyl-4 (1H) -pyrimidinone; ((2R,3S,5R)-5-(2-amino-5-methyl-4-oxopyrimidin-1(4H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate; 2'-Deoxy-5-methylisocytidine 5'-triphosphoric acid. CAS No. 139157-80-5. Molecular formula: C10H18N3O13P3. Mole weight: 481.18. | |
| 2'-Deoxyadenosine-15N1 | 2'-Deoxyadenosine-15N1 is an intermediate in the synthesis of 8-Oxo-2-deoxyguanosine-13C,15N2 (O850252). A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C10H13N415NO3. US Biological Life Sciences. | Worldwide |
| 2'-Deoxycytidine-5'-Triphosphate | 2'-Deoxycytidine-5'-Triphosphate is an indispensable constituent in the biomedical field, finding extensive application in DNA replication and diverse enzymatic reactions. Its significance lies in its contribution to DNA sequencing, mutagenesis, and gene expression investigations. Synonyms: dCTP; Deoxycytidine triphosphate. Grades: ≥95% by AX-HPLC. CAS No. 2056-98-6. Molecular formula: C9H16N3O13P3. Mole weight: 467.16. | |
| 2'-Deoxyinosine-5'-triphosphate sodium salt | 2'-Deoxyinosine-5'-triphosphate sodium salt, renowned for its multifarious applications in enzymatic labeling, sequencing, and mutagenesis, is a popular nucleotide analogue adopted in the biomedical industry. Apart from its widespread usage in these areas, it has also shown promising outcomes in treating viral infections and cancer. Synonyms: dITP.3Na; Inosine 5'-(tetrahydrogen triphosphate), 2'-deoxy-, trisodium salt; 9H-Purin-6-ol, 9-[2-deoxy-5-O-[hydroxy[[hydroxy (phosphonooxy) phosphinyl]oxy]phosphinyl]-β -D-erythro-pentofuranosyl]-, sodium salt (1:3); sodium ((2R,3S,5R)-3-hydroxy-5-(6-hydroxy-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl hydrogen triphosphate. Grades: ≥99% by HPLC. CAS No. 95648-77-4. Molecular formula: C10H12N4Na3O13P3. Mole weight: 558.11. | |
| 2'NH2-dCTP | 2'NH2-dCTP is a fascinating modified nucleotide, playing a crucial role in unraveling the intricacies of DNA research and development, replication, and repair. Acting as a remarkable substrate for DNA polymerases, it effortlessly integrates into DNA strands during enzymatic reactions. This exceptional compound finding widespread application in groundbreaking studies focused on mutagenesis, DNA labeling, and the detection of nucleic acids. Synonyms: 2'-Amino-2'-deoxycytidine-5'-triphosphate, Sodium salt; 2'-Amino-dCTP. Grades: ≥ 95% by HPLC. Molecular formula: C9H17N4O13P3 (free acid). Mole weight: 482.17 (free acid). | |
| 2'NH2-dGTP | 2'NH2-dGTP is a vital biomolecule used in compound serving as a modified nucleotide for DNA research and development, enabling the study and detection of DNA damage and repair. This unique compound finding applications in researching genetic diseases, mutagenesis analysis, and anticancer drug development. Its role in molecular biology facilitates a deeper understanding of nucleotide interactions and contributes to developments in disease reserch. Synonyms: 2'-Amino-2'-deoxyguanosine-5'-triphosphate, Sodium salt; 2'-Amino-dGTP. Grades: ≥ 95% by HPLC. Molecular formula: C10H17N6O13P3 (free acid). Mole weight: 522.20 (free acid). | |
| 3'-Amino-2',3'-dideoxyguanosine-5'-triphosphate lithium salt-100 mM aqueous solution | 3'-Amino-2',3'-dideoxyguanosine-5'-triphosphate lithium salt-100 mM aqueous solution is a valuable reagent extensively used in the biomedical industry. With exceptional stability and solubility, this solution is employed in various research applications such as PCR, DNA sequencing, and mutagenesis studies. It acts as a substrate for DNA polymerases during synthesis, aiding in the investigation of DNA structure and protein-DNA interactions. Synonyms: 3'-Amino-ddGTP.Li. Molecular formula: C10H17N6O12P3·xLi. Mole weight: 506.20 (free acid). | |
| 3'-Deoxycytidine-5'-triphosphate | 3'-Deoxycytidine-5'-triphosphate is a vital compound in diverse biomedical contexts, assuming a cardinal role in DNA assembly. As DNA polymerase relies on it as a substrate during replication and amplification events, its indispensability becomes pronounced. Furthermore, its significance extends to diagnostics, encompassing PCR, sequencing, and mutagenesis. Furthermore, its usage extends to explorations concerning antiviral compounds and the potential reserch of ailments such as cancer and viral infections. Synonyms: 3'-dCTP; 3'-deoxycytidine triphosphate. Grades: ≥95% by AX-HPLC. CAS No. 69383-05-7. Molecular formula: C9H16N3O13P3. Mole weight: 467.16. | |
| 3'-Deoxyguanosine-5'-triphosphate lithium salt | 3'-Deoxyguanosine-5'-triphosphate lithium salt is a pivotal constituent within the biomedical domain assuming the role of a substrate for DNA polymerases and DNA sequencing reactions. Its indispensability manifesting through its involvement in diverse molecular biology procedures, including site-directed mutagenesis, DNA labeling is and DNA sequencing. Molecular formula: C10H12N5O13P3Li4. Mole weight: 530.91. | |
| 3'-O-(2-nitrobenzyl)-2'-Deoxyadenosine-5'-Triphosphate | 3'-O-(2-nitrobenzyl)-2'-Deoxyadenosine-5'-Triphosphate is an indispensable component in the realm of biomedical research assuming a pivotal role as a robust investigative instrument, illuminating the intricate domains of DNA research and development and modification processes. Uniquely fashioned as a substrate for DNA polymerases, it seamlessly facilitates the comprehension of DNA repair mechanisms, the elucidation of mutagenesis is and the explication of DNA sequencing techniques. Synonyms: 3'-O-(2-nitrobenzyl)-2'-dATP. Grades: ≥95% by AX-HPLC. Molecular formula: C17H21N6O14P3. Mole weight: 626.30. | |
| 4-Thiothymidine-5'-Triphosphate | 4-Thiothymidine-5'-Triphosphate is a key component in biomedical research for studying DNA research and development and replication. It is a modified nucleotide that incorporates into DNA during replication, acting as an artificial base analog. This compound is used to investigate various processes such as DNA repair mechanisms, mutagenesis, antiviral drug development. Synonyms: 4-Thio-dTTP. Grades: ≥90% by AX-HPLC. Molecular formula: C10H17N2O13P3S. Mole weight: 498.24. | |
| 4-thiouridine | Nucleotide analogue is essential to cell growth in certain bacterial species, which is also able to chelate with certain metal ions, and in tRNA. It can act as a built-in antiphotomutagenic agent protecting Escherichia coli cells against mutagenesis. Uses: Affinity labels. Synonyms: Uridine, 4-thio-; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-sulfanylidene-1,2,3,4-tetrahydropyrimidin-2-one; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4-thioxo-pyrimidin-2-one; 1-beta-D-ribofuranosyl-4-thiouracil; 1-(β-D-Ribofuranosyl)-4-thioxo-3,4-dihydro-2(1H)-pyrimidinone. Grades: ≥95%. CAS No. 13957-31-8. Molecular formula: C9H12N2O5S. Mole weight: 260.27. | |
| 4-Thiouridine | Nucleotide analogue, essential for cell growth in certain bacterial species. This compound is also able to chelate with certain metal ions, and in tRNA it can act as a built-in antiphotomutagenic agent that protects Escherichia coli cells against mutagenesis. Group: Biochemicals. Alternative Names: Thiouridine; NSC 518132. Grades: Highly Purified. CAS No. 13957-31-8. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 5-Bromo-2'-deoxyuridine-5'-triphosphate sodium salt | 5-Bromo-2'-deoxyuridine-5'-triphosphate sodium salt, a pivotal constituent in the biomedical sector, serves as an indispensable catalyst in the realm of molecular biology exploration. This meticulously crafted creation finds its purpose as a substrate for the intricate process of DNA synthesis. Its ubiquitous application spans a myriad of scientific inquiries encompassing DNA sequencing, labeling, and mutagenesis, while simultaneously finding efficacy in drug screening and antiviral investigations. Synonyms: 5Br-dUTP; 5-BrdUTP. Molecular formula: C9H14N2O14P3Br. Mole weight: 547.04. | |
| 5-Iodocytidine 5'-triphosphate sodium salt | 5-Iodocytidine 5'-triphosphate sodium salt is a highly significant recompound in the field of compound, exhibiting profound importance in diverse areas including DNA sequencing, mutagenesis studies, nucleic acid development, RNA labeling research, gene expression analysis and viral diagnostics. Synonyms: Sodium ((2R,3S,4R,5R)-5-(4-amino-5-iodo-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl triphosphate; 59259-76-6. CAS No. 59259-76-6. Molecular formula: C9H15IN3O14P3. Mole weight: 609.05. | |
| 5-Propargylamino-dCTP - ATTO-550 | 5-Propargylamino-dCTP - ATTO-550 is a fluorescently labeled nucleotide used in biomedical research for applications such as DNA sequencing, mutagenesis and gene expression analysis. It enables detection and visualization of DNA research and development and replication processes, making it valuable in studying DNA repair mechanisms and protein-DNA interactions. Synonyms: 5-Propargylamino-2'-deoxycytidine-5'-triphosphate, labeled with ATTO 550, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C12H19N4O13P3- ATTO 550 (free acid). Mole weight: 1095.22 (free acid). | |
| 5-Propargylamino-ddCTP - ATTO-680 | 5-Propargylamino-ddCTP - ATTO-680 is a highly specialized fluorescent imaging probe that has been designed for the explicit purpose of detecting DNA synthesis within live cells. With its unparalleled specificity and sensitivity, this product represents the gold-standard within the biomedical industry for the diagnosis of cancer and the evaluation of cancer treatments. Moreover, due to its remarkable versatility, it is also widely employed in DNA sequencing and mutagenesis studies, where its unique properties enable more precise and accurate analysis of genetic material. Synonyms: 5-Propargylamino-2',3'-dideoxycytidine-5'-triphosphate, labeled with ATTO 680, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C12H19N4O12P3- ATTO 680 (free acid). Mole weight: 1011.22 (free acid). | |
| 5-Propargylamino-ddCTP - DY751 | 5-Propargylamino-ddCTP, a modified deoxycytosine triphosphate analog, aids in studying DNA replication, mutagenesis, and repair in biomedicine. Its versatile application contributes to the development of cancer treatments and antiviral agents in vitro, while facilitating accuracy in DNA polymerization. Synonyms: 5-Propargylamino-2',3'-dideoxycytidine-5'-triphosphate, labeled with DY 751, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C55H70N5O20P3S2 (free acid). Mole weight: 1278.22 (free acid). | |
| 7-Deaza-7-bromo-dATP | 7-Deaza-7-bromo-dATP is a nucleotide analogues involved in the domains of DNA sequencing, mutagenesis studies and as a substrate for polymerase chain reactions (PCR). Its exceptional utility lies in the evaluation of DNA research and development fidelity, enabling detailed exploration of the intricate dynamics underlying DNA damage repair mechanisms. Synonyms: (7-Deaza-7-Br-dATP); 7-Deaza-7-bromo-2'-deoxyadenosine-5'-triphosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C11H16N4O12P3Br (free acid). Mole weight: 569.09 (free acid). | |
| 8-(4-Amino-phenyl)-2'-deoxyguanosine | 8-(4-Amino-phenyl)-2'-deoxyguanosine is an analog of 8-Oxo-2'-deoxyguanosine; a marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. 8-Oxo-2'-deoxyguanosine can also induce differentiation of Friend murine erythroleukemia cells in vitro. Synonyms: 2'-Deoxy-7,8-dihydro-8-(4-amino-phenyl)-guanosine; 8-(4-amino-phenyl)-7,8-dihydro-2'-deoxyguanosine; 8-(4-Amino-phenyl)-7,8-dihydrodeoxyguanosine; 8-(4-Amino-phenyl)-dG. Molecular formula: C16H18N6O4. Mole weight: 358.35. | |
| 8-Hydroxyguanosine (8-OHG) | A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro. Group: Biochemicals. Alternative Names: 8-OHG. Grades: Highly Purified. CAS No. 3868-31-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 8-Oxo-2-deoxyguanosine-13C,15N2 | A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro. Group: Biochemicals. Alternative Names: 8-Hydroxy-2-deoxyguanosine-13C,15N2; 8-Oxo-7,8-dihydrodeoxyguanosine-13C,15N2; 2'-Deoxy-7,8-dihydro-8-oxo-guanosine-13C,15N2; 8-Oxo-7,8-dihydro-2'-deoxyguanosine-13C,15N2; 8-Oxo-dG-13C,15N2. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| 8-Oxoadenoosine-5'-Triphosphate | 8-Oxoadenosine-5'-Triphosphate, an ATP analog crucial for cell signaling and energy transfer, is integral to studying signal transduction pathways and disease mechanisms. It also aids in the DNA sequencing and mutagenesis studies through its ability to incorporate into DNA strands. Its widespread use in research has contributed to unravelling the mysteries hidden within cancer, inflammation, and neurological disorders. Synonyms: 8-Oxo-ATP; 8-Oxo-Adenosine-5'-Triphosphate. Grades: ≥95% by AX-HPLC. CAS No. 68745-44-8. Molecular formula: C10H16N5O14P3. Mole weight: 523.10. | |
| 8-Oxo-dGMP | 8-Oxo-dGMP is a nucleotide derivative commonly used in research to study DNA damage and repair mechanisms. It is often used to detect and quantify oxidation damage to DNA induced by reactive oxygen species, as well as to investigate the role of 8-oxo-dG in mutagenesis and carcinogenesis. 8-Oxo-dGMP has potential therapeutic applications for the treatment of diseases associated with oxidative stress, such as cancer and neurodegenerative disorders. Synonyms: 8-Oxo-2'-deoxyguanosine-5'-monophosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C10H14N5O8P (free acid). Mole weight: 363.22 (free acid). | |
| dKTP | dKTP is a triphosphate analogue with artificial base for directed mutagenesis experiments. Grades: ≥ 95% by HPLC. CAS No. 189278-08-8. Molecular formula: C11H19N6O13P3 (free acid). Mole weight: 536.2 (free acid). | |
| DNA-formamidopyrimidine glycosylase | May play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents. Also involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA. Group: Enzymes. Synonyms: Fapy-DNA glycosylase; deoxyribonucleate glycosidase; 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase; 2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase; formamidopyrimidine-DNA glycosylase; DNA-formamidopyrimidine glycosidase; Fpg protein. Enzyme Commission Number: EC 3.2.2.23. CAS No. 78783-53-6. Fpg Protein. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3977; DNA-formamidopyrimidine glycosylase; EC 3.2.2.23; 78783-53-6; Fapy-DNA glycosylase; deoxyribonucleate glycosidase; 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase; 2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase; formamidopyrimidine-DNA glycosylase; DNA-formamidopyrimidine glycosidase; Fpg protein. Cat No: EXWM-3977. |  |
| dTTPαS | dTTPαS is a modified nucleotide analogue used in enzymology and molecular biology research. It can be incorporated into DNA sequences during polymerase chain reaction (PCR) and is commonly used in site-directed mutagenesis studies. It has also been used in the study of DNA replication and repair mechanisms. Synonyms: 2'-Deoxythymidine-(α-thio)-triphosphate, Sodium salt (1 : 1 Mixture of Rp and Sp isomers). Grades: ≥ 95 % by HPLC. CAS No. 99749-43-6. Molecular formula: C10H17N2O13P3S.4Na. Mole weight: 586.19. | |
| Free Methionine-(R)-Sulfoxide Reductase from E. coli, recombinant | The Free Methionine-(R)-Sulfoxide Reductase (fRMsr) reduces free methionine sulfoxide (Met(O)) to methionine using thiol-disulfide exchange chemistry. This enzyme is involved in oxidative defense and known to form a sulfenic acid intermediate at the active site Cys during the course of turnover. In this variant, all Cys other than the peroxide-sensitive Cys have been removed by mutagenesis in order to stabilize the active site sulfenic acid with respect to disulfide bond formation. Applications: Free methionine-(r)-sulfoxide reductase (c84s, c94s), or frmsr, can be selectively derivatized at a single cys residue with a variety of cys-soh specific probes and be used as a positive control. Group: Enzymes. Enzyme Commission Number: EC 1.8.4.14. Purity: >98% by SDS-PAGE. Mole weight: 18,752 Da. Storage: at -80 °C. Form: Liquid. Source: E. coli. Free Methionine-(R)-Sulfoxide Reductase; fRMsr; EC 1.8.4.14. Cat No: NATE-1693. | |
| HIV-2 Protease, Recombinant | HIV-2 Protease, an aspartyl protease (retropepsin), is essential for the life-cycle of HIV-2 sub-type virus. It is expressed in the infected cells as a part of Gag-Pol polyprotein from which it is auto-catalytically released after formation of an immature viral particle. The enzyme subsequently cleaves the other parts of viral polyproteins resulting in the maturation of the virus. In HIV-infected patients, the enzyme is subjected to intensive mutagenesis and mutants resistant to applied medicines are produced as a result of the selection pressure. The mutation of HIV protease's active site or inhibition of its activity disrupts HIVs ability to replicate and infect additional ce...epsin; HIV-2 Protease (PR2); cd05482. Enzyme Commission Number: EC 3.4.23.-. Purity: > 85%. Mole weight: 38.3 kDa (1-99 aa + N-terminal GST and C-terminal Poly-his tags). It runs at ~31.5 kDa during SEC and SDS-PAGE analyses. Stability: Stable for at least 6 months as supplied. It can be further diluted to 0.5-1 mg/ml with 50 mM Sodium acetate, 100 mM NaCl, 5 mM DTT, 5 mM EDTA, pH 5.0 containing 10% glycerol, and stored at -80°C in aliquots. Do not keep the enzyme at 4°C or -20°C for extended time. Avoid repeated freezing and thawing cycles. Storage: Store at -80°C. Form: Liquid. Source: E. coli. HIV-2 retropepsin; HIV-2 Protease (PR2); cd05482; HIV2 protease. Cat No: NATE-1661. | |
| kallikrein 13 | The enzyme is specific for prorenin from the mouse submandibular gland, as prorenin from the mouse kidney (Ren1) and human prorenin are not substrates. Site-directed mutagenesis studies have shown that the enzyme will also cleave prorenin when Lys-Arg is replaced by Arg-Arg or Gln-Arg but the rate of reaction is much slower when Lys-Lys is used. This enzyme is also able to process pro-interleukin-1β (pro-IL-1β) in mouse submandibular gland to form IL-1&beta. Belongs in peptidase family S1A. Group: Enzymes. Synonyms: KLK13; kallikrein mK13; mGK-13; mK13; mKLK13; prorenin converting enzyme 1; PRECE-1; prorenin-converting enzyme; PRECE; proteinase P. Enzyme Commission Number: EC 3.4.21.119. CAS No. 342900-44-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4114; kallikrein 13; EC 3.4.21.119; 342900-44-1; KLK13; kallikrein mK13; mGK-13; mK13; mKLK13; prorenin converting enzyme 1; PRECE-1; prorenin-converting enzyme; PRECE; proteinase P. Cat No: EXWM-4114. | |
| N6-(6-Azido)hexyl-3'-dATP | N6-(6-Azido)hexyl-3'-dATP is a modified form of deoxyadenosine triphosphate (dATP). It is widely used in the biomedical industry for labeling and detection purposes, particularly in DNA sequencing and site-specific mutagenesis studies. Its azide group enables efficient click chemistry reactions, facilitating the attachment of various tags or probes. Synonyms: N6-(6-Azido)hexyl-3'-deoxyadenosine-5'-triphosphate. Grades: ≥ 95 % by HPLC. Molecular formula: C16H27N8O12P3(free acid). Mole weight: 616.35 (free acid). | |
| N-Acetyl-β-D-Glucosamine 6-Acetate 1,3,4-Tribenzyl Ether | N-Acetyl-β-D-Glucosamine 6-Acetate 1,3,4-Tribenzyl Ether is a derivative of N-Acetyl-D-Glucosamine 6-Acetate, used in the preparation of the active mutant subtilisin BPN' in DMF via site-directed mutagenesis. Synonyms: Phenylmethyl 2-(Acetylamino)-2-deoxy-3,4-bis-O-(phenylmethyl)-β-D-glucopyranoside 6-Acetate. CAS No. 129729-33-5. Molecular formula: C31H35NO7. Mole weight: 533.61. | |
| Native Calf Terminal Transferase | Bovine terminal transferase (TdT) is a primer-dependent polymerase that catalyzes the addition of deoxynucleotides to the 3'-OH terminus of DNA molecules with the release of inorganic phosphate. TdT reacts preferentially with either single-stranded DNA molecules or double-stranded-DNA with 3' overhangs, but procedures have been developed to label blunt ends or 3'-recessive ends. In a reaction mixture, the divalent ion (Co2+, Mn2+, Mg2+) will influence purine and pyrimidine polymerization rate. Activities of TdT are also affected by the bases (dATP, dCTP, dGTP and dTTP) present. Bovine terminal transferase (tdt) is a primer-dependent polymerase that catalyzes the addition of d...ed dna with non-radioactive or radioactive labels o carrying out in vitro mutagenesis by adding single nucleotides to dna o use in tunel assays. Group: Enzymes. Synonyms: DNA nucleotidylexotransferase; terminal deoxyribonucleotidyltransferase; terminal addition enzyme; addase; deoxynucleotidyl terminal transferase; deoxyribonucleic acid nucleotidyltransferase; deoxyribonucleic nucleotidyltransferase; terminal deoxynucleotide transferase; TdT; EC 2.7.7.31; 9027-67-2. Enzyme Commission Number: EC 2.7.7.31. CAS No. 9027-67-2. TdT. Mole weight: mol wt 60 kDa. Storage: -20°C. Form: buffered aqueous glycerol solution. Source: Calf thymus. Species: Calf. DNA nucleotidylexotransferas | |
| N-Butyl-N-(4-hydroxybutyl)nitrosamine | N-Butyl-N-(4-hydroxybutyl)nitrosamine is a potent mutagen that can cause high-level of mutagenesis specifically in the epithelial cells (urothelial) of the urinary bladder. N-Butyl-N-(4-hydroxybutyl)nitrosamine is used to induce bladder cancer in rodents [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3817-11-6. Pack Sizes: 100 mg. Product ID: HY-W755252. | |
| (R)-5,7-Dimethoxyflavanone | (R)-5,7-Dimethoxyflavanone shows potent antimutagenic activity against MeIQ mutagenesis in Ames test using the S. typhimurium TA100 and TA98 strains [1]. And (R)-5,7-Dimethoxyflavanone significantly and dose-dependently inhibits the inflammatory mediato [1]. Uses: Scientific research. Group: Natural products. CAS No. 1277188-85-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N5054. | |
| RO-0335 | RO-0335 is a novel diphenylether nonnucleoside reverse transcriptase inhibitor. Two pathways to loss of susceptibility to RO-0335 were observed, containing patterns of amino acid changes at either V106I/A plus F227C (with additional contributions from A98G, V108I, E138K, M230L and P236L) or V106I/Y188L (with a potential contribution from L100I, E138K and Y181C). Characterization of the observed mutations by site-directed mutagenesis in the isogenic HXB2D background demonstrated that a minimum of two or more mutations were required for significant loss of susceptibility, with the exception of Y188L, which requires a two-nucleotide change. Patterns containing F227C or quadruple mutations selected by RO-0335 showed a low relative fitness value when compared to wild-type HXB2D. Group: Inhibitors. Alternative Names: RO0335; RO-0335; RO 0335. CAS No. 867365-76-2. Molecular formula: C21H13BrCl2FN3O4S. Mole weight: 573.22. Appearance: Solid powder. Purity: >98%. IUPACName: 2-(4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl)-N-(2-chloro-4-sulfamoylphenyl)acetamide. Canonical SMILES: O=C (NC1=CC=C (S (=O) (N)=O)C=C1Cl)CC2=CC=C (Br)C (OC3=CC (C#N)=CC (Cl)=C3)=C2F. Catalog: ACM867365762. |  |
| signal peptidase I | The enzyme is found in bacterial membranes and in chloroplast thylakoid membranes. Unaffected by inhibitors of most serine peptidases, but site-directed mutagenesis implicates a Ser/Lys catalytic dyad in activity. Hydrolyses a single bond -Ala?Ala- in M13 phage procoat protein, producing free signal peptide and coat protein. Formerly included in EC 3.4.99.36. Eukaryote signal peptidases that may have somewhat different specificity are known from the endoplasmic reticulum membrane and mitochondrial inner membrane. Type example of peptidase family S26. Group: Enzymes. Synonyms: leader peptidase I; signal proteinase. Enzyme Commission Number: EC 3.4.21.89. CAS No. 65979-36-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4180; signal peptidase I; EC 3.4.21.89; 65979-36-4; leader peptidase I; signal proteinase; Escherichia coli leader peptidase; eukaryotic signal peptidase; eukaryotic signal proteinase; leader peptidase; leader peptide hydrolase; leader proteinase; signal peptidase; pilin leader peptidase; SPC; prokaryotic signal peptidase; prokaryotic leader peptidase; HOSP; prokaryotic signal proteinase; propeptidase; PuIO prepilin peptidase; signal peptide hydrolase; signal peptide peptidase; signalase; bacterial leader peptidase 1; pilin leader peptidase. Cat No: EXWM-4180. | |
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