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| Product | Description | |
|---|---|---|
| myosin ATPase | Proteins of the contractile apparatus of muscle and nonmuscle cells; myosin molecule consists of two heavy chains (about 200 kDa) and two pairs of light chains (15-27 kDa). The head region of the heavy chain contains actin- and ATP-binding sites. ATP hydrolysis provides energy for actomyosin contraction. Group: Enzymes. Enzyme Commission Number: EC 3.6.4.1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4699; myosin ATPase; EC 3.6.4.1. Cat No: EXWM-4699. |  |
| Myosin, Calcium activated from porcine heart | buffered aqueous glycerol solution, 0.1-0.5 units/mg protein (biuret). Group: Fluorescence/luminescence spectroscopy. |  |
| Myosin, Calcium activated from rabbit muscle | buffered aqueous glycerol solution, 0.5-1.5 units/mg protein (biuret). Group: Fluorescence/luminescence spectroscopy. | |
| Myosin Heavy Chain from rabbit muscle | buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| myosin-heavy-chain kinase | The enzyme from Dictyostelium sp. (slime moulds) brings about phosphorylation of the heavy chains of Dictyostelium myosin, inhibiting the actin-activated ATPase activity of the myosin. One threonine residue in each heavy chain acts as acceptor. While the enzyme from some species is activated by actin, in other cases Ca2+/calmodulin are required for activity. Group: Enzymes. Synonyms: ATP:myosin-heavy-chain O-phosphotransferase; calmodulin-dependent myosin heavy chain kinase; MHCK; MIHC kinase; myosin heavy chain kinase; myosin I heavy-chain kinase; myosin II heavy-chain kinase; [myosin-heavy-chain] kinase; myosin heavy chain kinase A; STK6. Enzyme Commission Number: EC 2.7.11.7. CAS No. 64763-54-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3158; myosin-heavy-chain kinase; EC 2.7.11.7; 64763-54-8; ATP:myosin-heavy-chain O-phosphotransferase; calmodulin-dependent myosin heavy chain kinase; MHCK; MIHC kinase; myosin heavy chain kinase; myosin I heavy-chain kinase; myosin II heavy-chain kinase; [myosin-heavy-chain] kinase; myosin heavy chain kinase A; STK6. Cat No: EXWM-3158. | |
| myosin-light-chain kinase | Requires Ca2+ and calmodulin for activity. The 20-kDa light chain from smooth muscle myosin is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors, but more slowly. Group: Enzymes. Synonyms: [myosin-light-chain] kinase; ATP:myosin-light-chain O-phosphotransferase; calcium/calmodulin-dependent myosin light chain kinase; MLCK; MLCKase; myosin kinase; myosin light chain kinase; myosin light chain protein kinase; myosin light-chain kinase (phosphorylating); smooth-muscle-myosin-light-chain kinase; STK18. Enzyme Commission Number: EC 2.7.11.18. CAS No. 51845-53-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3137; myosin-light-chain kinase; EC 2.7.11.18; 51845-53-5; [myosin-light-chain] kinase; ATP:myosin-light-chain O-phosphotransferase; calcium/calmodulin-dependent myosin light chain kinase; MLCK; MLCKase; myosin kinase; myosin light chain kinase; myosin light chain protein kinase; myosin light-chain kinase (phosphorylating); smooth-muscle-myosin-light-chain kinase; STK18. Cat No: EXWM-3137. | |
| Myosin Light Chain Kinase Inhibitor Peptide 18 | The Myosin Light Chain Kinase Inhibitor Peptide 18 controls the biological activity of Myosin Light Chain Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Myosin IIA, non muscle antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Myosin IIB, non-muscle antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Myosin I? (Nuclear) antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Myosin IX/Myr5 antibody produced in rabbit | IgG fraction of antiserum, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Myosin (Skeletal and Smooth) antibody produced in rabbit | whole antiserum. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Myosin (Skeletal) antibody produced in rabbit | whole antiserum. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Myosin (Skeletal, Fast) antibody, Mouse monoclonal | clone MY-32, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Myosin Va (LE-16) antibody produced in rabbit | ~0.5 mg/mL, affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Myosin Va (LF-18) antibody produced in rabbit | ~0.4 mg/mL, affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Myosin VI (KA-15) antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-phospho-Myosin regulatory light chain 2 (pSer18) antibody produced in rabbit | affinity isolated antibody. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-Myosin Light Chain Kinase antibody produced in mouse | clone K36, ascites fluid. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-Myosin (Light Chains 20 kDa) antibody produced in mouse | clone MY-21, ascites fluid. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-Myosin (Skeletal, Fast)?Alkaline Phosphatase antibody produced in mouse | clone MY-32, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-Myosin (Skeletal, Fast) antibody produced in mouse | clone MY-32, ascites fluid. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-Myosin (Skeletal, Slow) antibody produced in mouse | clone NOQ7.5.4D, ascites fluid. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-Myosin (Smooth) antibody produced in mouse | clone hSM-V, ascites fluid. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-Myosin VI antibody produced in mouse | ~1 mg/mL, clone MUD-19, purified immunoglobulin, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| [myosin-light-chain] phosphatase | The enzyme is composed of three subunits. The holoenzyme dephosphorylates myosin light chains and EC 2.7.11.18, myosin-light-chain kinase, but not myosin; the catalytic subunit acts on all three substrates. Group: Enzymes. Synonyms: myosin light chain kinase phosphatase; myosin phosphatase; myosin phosphatase; protein phosphatase 2A; myosin-light-chain-phosphatase. Enzyme Commission Number: EC 3.1.3.53. CAS No. 60241-39-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3658; [myosin-light-chain] phosphatase; EC 3.1.3.53; 60241-39-6; myosin light chain kinase phosphatase; myosin phosphatase; myosin phosphatase; protein phosphatase 2A; myosin-light-chain-phosphatase. Cat No: EXWM-3658. | |
| Native Human Myosin Subfragment-1 | Myosins comprise a family of ATP-dependent motor proteins and are best known for their role in muscle contraction and their involvement in a wide range of other motility processes in eukaryotes. They are responsible for actin-based motility. The term was originally used to describe a group of similar ATPases found in the cells of both striated muscle tissue and smooth muscle tissue. Applications: Diagnostic controls, calibrators & standards; testing/assay validation; life science; manufacturing. Group: Others. Synonyms: Myosin Subfragment-1; Myosin; Myosin S-1; Myosin 1. Activity: 1 mg/mg solid. Stability: 5 years. Storage: Store at -20°C. Form: Lyophilized from 0.02 mM tris, 0.2 M sodium chloride, pH 8.5. Source: Human Heart. Species: Human. Myosin Subfragment-1; Myosin; Myosin S-1; Myosin 1. Cat No: NATE-0968. | |
| Unconventional myosin-Ib (911-919) | A peptide fragment of Unconventional myosin-Ib. Unconventional myosin-Ib is a motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport. Synonyms: MYH-1c (911-919); Myosin I alpha (911-919). |  |
| 1,12-Diaminododecane | 1,12-Diaminododecane is a long aliphatic diamine that is known to inhibit specific phospholipid-sensitive enzymes and myosin light-chain kinases. Group: Biochemicals. Grades: Highly Purified. CAS No. 2783-17-7. Pack Sizes: 5g, 25 g. Molecular Formula: C12H28N2, Molecular Weight: 200.36. US Biological Life Sciences. |  Worldwide |
| 1-[4-(4-Ethoxyphenyl)thiazol-2-yl]-guanidine Hydrobromide | 1-[4-(4-Ethoxyphenyl)thiazol-2-yl]-guanidine Hydrobromide is related to 1-(4-(4-Methoxyphenyl)thiazol-2-yl)guanidine Hydrobromide (M226305), which is used in the preparation of antiulcer agents, specifically 4-Substituted 2-guanidinothiazoles, which are reversible, competitive, and selective inhibitors of gastric H+,K+-ATPase. 1-(4-(4-Methoxyphenyl)thiazol-2-yl)guanidine Hydrobromide is also used in the preparation of thiazole compounds as myosin light chain phosphatase inhibitors for prostate cancer treatment. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250mg, 500mg. Molecular Formula: C12H14N4OS; HBr, Molecular Weight: 262.34. US Biological Life Sciences. | Worldwide |
| 1-(4-(4-Methoxyphenyl)thiazol-2-yl)guanidine Hydrobromide | 1-(4-(4-Methoxyphenyl)thiazol-2-yl)guanidine Hydrobromide is used in the preparation of antiulcer agents, specifically 4-Substituted 2-guanidinothiazoles, which are reversible, competitive, and selective inhibitors of gastric H+,K+-ATPase. 1-(4-(4-Methoxyphenyl)thiazol-2-yl)guanidine Hydrobromide is also used in the preparation of thiazole compounds as myosin light chain phosphatase inhibitors for prostate cancer treatment. Group: Biochemicals. Grades: Highly Purified. CAS No. 96996-05-3. Pack Sizes: 500mg, 1g. Molecular Formula: C11H12N4OS; HBr, Molecular Weight: 248.31. US Biological Life Sciences. | Worldwide |
| 1- (8-Chloro-5-isoquinolinesulfonyl) piperazine, Dihydrochloride (HA-156) | Inhibits both Ca2+ dependent myosin phosphorylation by MLC-Kinase and protein kinase C. Group: Biochemicals. Alternative Names: HA-156. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 2,3-Butanedione-2-monoxime | 2,3-Butanedione-2-monoxime (BDM) is a non-selective, reversible myosin ATPase inhibitor with phosphatase-like properties. It is non-selective myosin ATPase inhibitor (Ki = 5 mM at myosin II). Uses: Cholinesterase reactivators. Synonyms: BDM; Diacetyl Monoxime; NSC 660; NSC 116103; Biacetyl monooxime. Grades: ≥95%. CAS No. 57-71-6. Molecular formula: C4H7NO2. Mole weight: 101.1. | |
| 2,3-Butanedione 2-Monoxime | 2,3-Butanedione 2-Monoxime is a reversible inhibitor of myosin ATPase. Group: Biochemicals. Grades: Highly Purified. CAS No. 57-71-6. Pack Sizes: 25g, 50g. Molecular Formula: C4H7NO2, Molecular Weight: 101.1. US Biological Life Sciences. | Worldwide |
| 3,5-Diiodothyropropionic acid | 3,5-Diiodothyropropionic acid is a thyroid hormone analog, induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (TR) , with K a of 2.40 and 4.06 M -1 for TRα1 and TRβ1, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1158-10-7. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 5 mg; 10 mg. Product ID: HY-126236. |  |
| 3-Methyl-L-histidine | 3-Methyl-L-histidine is an endogenous amino acid that can be found in actin and myosin [1]. Uses: Scientific research. Group: Natural products. CAS No. 368-16-1. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-W017007. | |
| 4-(2-Iodoacetamido)-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical | 4-(2-Iodoacetamido)-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical. Uses: Spin-label used to study phosphoenolpyruvate carboxykinase and gtp binding sites, also used to assess sh1 and sh2 myosin alkylation. Group: Organic radicalsbattery materials electronic materials. Alternative Names: 4-(2-Iodoacetamido)-TEMPO Free Radical. CAS No. 25713-24-0. Molecular formula: 339.2. Mole weight: C11H20IN2O2. CC1(CC(CC(N1[O])(C)C)NC(=O)CI)C. InChI=1S/C11H20IN2O2/c1-10 (2)5-8 (13-9 (15)7-12)6-11 (3, 4)14 (10)16/h8H, 5-7H2, 1-4H3, (H, 13, 15). UCTVRHAKQRFPEZ-UHFFFAOYSA-N. >98.0%(HPLC). |  |
| 8-[(6-Amino)hexyl]-amino-ATP - ATTO-Rho13 | 8-[(6-Amino)hexyl]-amino-ATP-ATTO-Rho13 is a fluorescent label commonly utilized for tracking the kinetics of ATP-dependent proteins, such as actin and myosin. It can also be used as a tool for monitoring various ATP analogs and inhibitors. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-5'-triphosphate, labeled with ATTO Rho13, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C57H75N10O16P3 (free acid). Mole weight: 1248.46 (free acid). | |
| a-3 Hydrochloride | A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM) and myosin light chain kinase (MLCK) (Ki=7.4 μM). A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively. Uses: Designed for use in research and industrial production. Additional or Alternative Names: A3, Hydrochloride, A3 hydrochloride, IN1547, N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide hydrochloride, N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide, HCl, A-3HYDROCHLORIDE, A1980_SIGMA, SCHEMBL3503907, CHEMBL1255867, CTK7E9088, OR0890T, MolPort-001-756-823, CCG-222331, LP01027, NCGC00094317-01, 3B3-053691, N-(2-Aminoethyl)-5-chloronaphthalene-1-sulphonamide hydrochloride, N-(2-AMINOETHYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE, HYDROCHLORIDE, 78957-85-4. Product Category: Inhibitors. CAS No. 78957-85-4. Molecular formula: C12H14Cl2N2O2S. Mole weight: 321.22. Purity: 0.96. IUPACName: N-(2-aminoethyl)-5-chloronaphthalene-1-sulfonamide;hydrochloride. Product ID: ACM78957854. Alfa Chemistry ISO 9001:2015 Certified. |  |
| A-3 hydrochloride | A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA ( K i =4.3 μM), casein kinase II ( K i =5.1 μM) and myosin light chain kinase (MLCK) ( K i =7.4 μM). A-3 hydrochloride also inhibits PKC and casein kinase I with K i values of 47 μM and 80 μM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 78957-85-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-125957. | |
| Aficamten | Aficamten, also known as CK-3773274 and CK-274, is a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy. Aficamten was designed to provide a predicted human half-life (t1/2) appropriate for once a day (qd) dosing, to reach steady state within two weeks, to have no substantial cytochrome P450 induction or inhibition, and to have a wide therapeutic window in vivo with a clear pharmacokinetic/pharmacodynamic relationship. In a phase I clinical trial, aficamten demonstrated a human t1/2 similar to predictions and was able to reach steady state concentration within the desired two-week window. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CK-3773274; CK3773274; CK 3773274; CK-274; CK274; CK 274. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2364554-48-1. Molecular formula: C18H19N5O2. Mole weight: 337.38. Purity: >98%. IUPACName: N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl-1H-pyrazole-4-carboxamide. Canonical SMILES: O=C(C1=CN(C)N=C1)N[C@@H]2CCC3=C2C=CC(C4=NOC(CC)=N4)=C3. Product ID: ACM2364554481. Alfa Chemistry ISO 9001:2015 Certified. | |
| Aficamten | Aficamten (CK-274) is a potent cardiac myosin inhibitor with an IC 50 of 1.4 μM. Aficamten can be used for the research of hypertrophic cardiomyopathy (HCM) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CK-274; CK-3773274. CAS No. 2364554-48-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139465. | |
| Altenusin | Altenusin is a a biphenyl derivative with an IC50 value of 4.3±0.3 μM in the TR assay, which is isolated from the endophytic fungus Alternaria. It inhibits Src kinase with an IC50 value of 20 nM. Altenusin inhibits fibrillization of recombinant tau fragments in vitro and phosphorylation of tau in SH-SY5Y cells expressing human P301L mutant tau when used at a concentration of 10 μM. Altenusin is known to have antioxidant properties and to inhibit several enzymes, including myosin light chain kinase, sphingomyelinase, acetylcholinesterase, cFMS kinase, pp60c-SRc kinase and HIV-1 integrase. Synonyms: Alutenusin; MS 341; MS-341; MS341. Grades: ≥98%. CAS No. 31186-12-6. Molecular formula: C15H14O6. Mole weight: 290.27. | |
| Altenusin, Penicillium sp. | Sphingomyelinase (N-SMase) and strong pp60c-Src inhibitor. Inhibits cFMS receptor tyrosine kinase (CSF-1/m-CSF receptor tyrosine kinase) which is implicated in cancer and bone diseases. Myosin light chain kinase inhibitor. Also exhibits anti-HIV-1 integrase activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 31186-12-6. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Antibiotic K252A (Antibiotic SF 2370) | Antibiotic K252A is a staurosporine analogue isolated from a Nocardiopsis strain as a potent inhibitor of protein kinase C. Antibiotic K252A exhibits potent antitumor activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents. More extensive investigation has demonstrated that while antibiotic K252A is a potent inhibitor of Ca2+/calmodulin kinase II, it is also active against other kinases, notably myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and cGMP-dependent protein kinase (PKG). Group: Biochemicals. Grades: Highly Purified. CAS No. 99570-78-2. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Blebbistatin | Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. Blebbistatin blocks cell migration [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 674289-55-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13813. | |
| (-)-Blebbistatin | (-)-Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Synonyms: (S)-(-)-Blebbistatin; (S)-blebbistatin; (3aS)-3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one. Grades: >98%. CAS No. 856925-71-8. Molecular formula: C18H16N2O2. Mole weight: 292.33. | |
| (-)-Blebbistatin | (-)-Blebbistatin is a selective inhibitor of the ATPase activity of non-muscle myosin II [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 856925-71-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13441. | |
| (+)-Blebbistatin | (+)-Blebbistatin is the inactive enantiomer of Blebbistatin, an inhibitor of myosin II ATPase. (+)-Blebbistatin can be used as a negative control of the active enatiomer (-)-Blebbistatin. Synonyms: (R)-(+)-Blebbistatin; (3aR)-(+)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one. Grades: ≥99% by HPLC. CAS No. 1177356-70-5. Molecular formula: C18H16N2O2. Mole weight: 292.34. | |
| (+)-Blebbistatin | (+)-Blebbistatin is the inactive enantiomer of ( - )-Blebbistatin. ( - )-Blebbistatin is a selective inhibitor of myosin II ATPase [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1177356-70-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107657. | |
| (±)-Blebbistatin | (±)-Blebbistatin is a selective inhibitor of myosin II ATPase. It reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Synonyms: Blebbistatin; (±)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one. Grades: ≥98% by HPLC. CAS No. 674289-55-5. Molecular formula: C18H16N2O2. Mole weight: 292.34. | |
| (+/-)-Blebbistatin ((+/-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one) | Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing. Group: Biochemicals. Alternative Names: (+/-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one. Grades: Highly Purified. CAS No. 674-289-55-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| BTS | A potent inhibitor of skeletal muscle Ca2+-stimulated myosin S1 ATPase (IC50 approx. 5uM) activity. Reversible blocks the gliding motility. Also weakens myosin's interaction with F-actin. Does not affect platelet myosin II. Synonyms: BTS; BnNHTs; N-Benzyl-p-toluenesulfonamide; N-Tosylbenzylamine. Grades: >98%. CAS No. 1576-37-0. Molecular formula: C14H15NO2S. Mole weight: 261.34. | |
| BTS | BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of skeletal muscle myosin II subfragment 1 (S1) ATPase activity, with an IC 50 s of ~5 μM for actin- and Ca 2+ -stimulated myosin S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle fibers [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N-Benzyl-p-toluenesulfonamide; N-Tosylbenzylamine. CAS No. 1576-37-0. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-16690. | |
| Ca2+/calmodulin-dependent protein kinase | Requires calmodulin and Ca2+ for activity. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase) or EC 2.7.11.26 (tau-protein kinase). Group: Enzymes. Synonyms: ATP:caldesmon O-phosphotransferase; caldesmon kinase; caldesmon kinase (phosphorylating); Ca2+/calmodulin-dependent microtubule-associated pro. Enzyme Commission Number: EC 2.7.11.17. CAS No. 141467-21-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3136; Ca2+/calmodulin-dependent protein kinase; EC 2.7.11.17; 141467-21-2; ATP:caldesmon O-phosphotransferase; caldesmon kinase; caldesmon kinase (phosphorylating); Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase; Ca2+/calmodulin-dependent protein kinase 1; Ca2+/calmodulin-dependent protein kinase II; Ca2+/calmodulin-dependent protein kinase IV; Ca2+/calmodulin-dependent protein kinase kinase; Ca2+/calmodulin-dependent protein kinase kinase β; calmodulin-dependent kinase II; CaM kinase; CaM kinase II; CAM PKII; CaM-regulated serine/threonine kinase; CaMKI; CaMKII; CaMKIV; CaMKKα; CaMKKβ; microtubule-associated protein 2 kinase; STK20. Cat No: EXWM-3136. | |
| Calmodulin Antagonist W-12 (N-(4-aminobutyl)-2-naphthalenesulfonamide hydrochloride) | Antagonist of calmodulin, inhibiting activation of Ca2+/calmodulin-dependent phosphodiesterase (PDE I) and myosin light chain kinase. Group: Biochemicals. Alternative Names: N-(4-aminobutyl)--2-naphthalenesulfonamide hydrochloride. Grades: Molecular Biology Grade. CAS No. 89108-46-3. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Calmodulin Antagonist W-5 | Antagonist of calmodulin, inhibiting Ca2+/calmodulin-regulated phosphodiesterase (PDE I) and myosin light chain kinase. Group: Biochemicals. Alternative Names: N-(6-Aminohexyl)-1-naphthalenesulfonamide Hydrochloride. Grades: Molecular Biology Grade. CAS No. 61714-25-8. Pack Sizes: 5mg, 25mg, 50mg, 100mg. Molecular Formula: C??H??ClN?O?S. US Biological Life Sciences. | Worldwide |
| Calphostin C (UCN 1028C, PKF115-584, Cal-C) | Potent and highly specific cell permeable protein kinase C (PKC) inhibitor. The inhibition of PKC is light-dependent. PKA, PKG, DAG kinase, phospholipase D1 and D2, myosin light chain kinase and c-Src inhibitor. Anticancer compound. Inhibits cell proliferation and strongly induces apoptosis in vitro. Inducer of endoplasmic reticulum ER-stress. Shown to directly and potently block L-type Ca channels. Calphostin C specifically inhibits contraction-stimulated glucose transport but not insulin-stimulated glucose transport in skeletal muscle. Wnt/beta-catenin/lef-1 signaling inhibitor. beta-catenin/TCF antagonist. Inhibits Wnt-activated genes in a dose-dependent fashion. Source:Cladosporium cladosporioides sp. Group: Biochemicals. Grades: Highly Purified. CAS No. 121263-19-2. Pack Sizes: 100ug, 1mg. Molecular Formula: C44H38O14 , Molecular Weight: ~790.8. US Biological Life Sciences. | Worldwide |
| Cdc25 Inhibitor IV, NSC 95397 (2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedione, PTP Inhibitor XXIX) | A cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (Ki=32nM, 96nM, and 40nM for Cdc25A, -B, and -C, respectively) and blocks G2M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC50=1.8uM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments. Group: Biochemicals. Grades: Highly Purified. CAS No. 93718-83-3. Pack Sizes: 10mg. Molecular Formula: C??H??O?S?, Molecular Weight: 310.4. US Biological Life Sciences. | Worldwide |
| cis-4-Hydroxy-L-proline | cis-4-Hydroxy-L-proline. Uses: Cis-4-hydroxy-l-proline (chp) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. chp blocked myotube formation and expression of sarcomeric myosin heavy chain in c2c12 murine skeletal muscle cells. chp inhibited proliferation of murine panc02 pancreatic carcinoma cell line and rat pancreatic carcinoma cell line dsl6a. Additional or Alternative Names: (2S,4S)-(-)-4-Hydroxy-2-pyrrolidinecarboxylic acid, CHP. Product Category: Amino Acids. CAS No. 618-27-9. Mole weight: 131.13. Canonical SMILES: O[C@@H]1CN[C@@H](C1)C(O)=O. ECNumber: 210-542-1. Product ID: ACM618279. Alfa Chemistry ISO 9001:2015 Certified. | |
| CK 1827452 | CK-1827452 is a diaryl urea compound that increases cardiac myosin ATPase activity in a dose-dependent manner that is selective for cardiac myosin over non-cardiac myosins. It promotes myosin cross-bridge formation, increasing the duration and amount of myocyte contraction without affecting intracellular calcium or cAMP. It has been shown to increase cardiac efficiency in clinical studies of patients with chronic heart failure. Group: Biochemicals. Alternative Names: Methyl 4- [ [2-Fluoro-3- [N'- (6-methylpyridin-3-yl) ureido] phenyl] methyl] piperazine-1-carboxylate; 4- [ [2-Fluoro-3- [ [ [ (6-methyl-3-pyridinyl) amino] carbonyl] amino] phenyl] methyl] -1-piperazinecarboxylic Acid Methyl Ester; Omecamtiv Mecarbil. Grades: Highly Purified. CAS No. 873697-71-3. Pack Sizes: 5mg, 10mg. Molecular Formula: C??H??FN?O?, Molecular Weight: 401.43. US Biological Life Sciences. | Worldwide |
| Danicamtiv | Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Danicamtiv; MYK-491; MYK 491; MYK491. Product Category: Activators. Appearance: Solid powder. CAS No. 1970972-74-7. Molecular formula: C16H20F3N5O4S. Mole weight: 435.42. Purity: >98%. IUPACName: 4-(1-((3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)sulfonyl)-1-fluoroethyl)-N-(isoxazol-3-yl)piperidine-1-carboxamide. Canonical SMILES: FC(C1CCN(C(NC2=NOC=C2)=O)CC1)(C)S(C3=CN(C)N=C3C(F)F)(=O)=O. Product ID: ACM1970972747. Alfa Chemistry ISO 9001:2015 Certified. | |
| Deoxyblebbistatin | A derivative of Blebbistatin, a compound that blockes myosin II-dependent cell processes. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| D-erythro-Sphingosine | D-erythro-Sphingosine is a natural isomer of sphingosine and acts as an inhibitor of protein kinase C and calmodulin-dependent enzymes with no effects on protein kinase A or myosin light chain kinase. It may stimulate mast cells by activation of protein kinase C. Synonyms: Sphingosine (d18:1); sphingosine; D-Sphingosine; 4-Sphingenine; 2S, 3R(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol; (2S,3R,4E)-2-amino-1,3-octadec-4-enediolsphing-4-enine. Grades: >99%. CAS No. 123-78-4. Molecular formula: C18H37NO2. Mole weight: 299.49. | |
| EDA-ATPγS - ATTO-Rho14 | EDA-ATPγS - ATTO-Rho14, a fluorescent nucleotide analog, finds its usage in investigating actin-myosin interactions and studying septin filament turnover in various biological systems. With its versatile applications in assays of G protein-coupled receptor activity and its diagnostic usage in neurodegenerative disorders like Alzheimer's, EDA-ATPγS - ATTO-Rho14 stands as an indispensable tool for modern researchers and clinicians alike. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-adenosine-5'-(γ-thio)-triphosphate, labeled with ATTO Rho14, Triethylammonium salt. Grades: ≥ 90 % by HPLC, contains approx. 5 % EDA-ADP-dye. Molecular formula: C54H63Cl4N10O16P3S (free acid). Mole weight: 1372.21 (free acid). | |
| Fmoc-erythro-Sphingosine ( (2S, 3R, 4E) -2-Fluorenyl methoxycarbonyl amino-4-octadecen-1, 3-diol) | The N-Fmoc protected Sphingosine, a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets; does not inhibit protein kinase A or myosin light chain kinase; inhibits calmodulin-dependent enzymes. Group: Biochemicals. Alternative Names: (2S, 3R, 4E) -2-Fluorenyl methoxycarbonyl amino-4-octadecen-1, 3-diol. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| fragilysin | Thought to be a cause of diarrhoea in animals and humans. Hydrolyses extracellular matrix proteins, and disrupts tight junctions of intestinal epithelial cells. Also degrades intracellular, cytoskeletal proteins actin, myosin and others. In peptidase family M10 (interstitial collagenase family). Group: Enzymes. Synonyms: Bacteroides fragilis (entero)toxin. Enzyme Commission Number: EC 3.4.24.74. CAS No. 188596-63-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4358; fragilysin; EC 3.4.24.74; 188596-63-6; Bacteroides fragilis (entero)toxin. Cat No: EXWM-4358. | |
| H-7 dihydrochloride | H-7 dihydrochloride is a protein kinase inhibitor (IC50 = 6.0, 5.8, 3.0 and 97.0 μM for inhibition of PKC, PKG, PKA and myosin light chain kinase, respectively). H-7 inhibits cell invasion and metastasis in B16BL6 cancer cells through the PKC/MEK/ERK pathway. It was also shown to inhibit Topo I and II in murine L929 cells and induce apoptosis via PKC inhibition. Synonyms: H7 dihydrochloride; H7 HCl. (±)-1-(5-Isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 108930-17-2. Molecular formula: C14H17N3O2S.2HCl. Mole weight: 364.29. | |
| H-89 dihydrochloride (N-5-isoquinolinesulfonamid e . 2HCl) | Cell permeable potent and selective cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor. Protein kinase Cµ (PKCµ) inhibitor. Ca2+/calmodulin-dependent protein kinase II inhibitor. Casein kinase I inhibitor. Myosin light chain kinase (MLCK) inhibitor. Apoptosis enhancer. Tool to study protein crystal structure-inhibitor interactions. Rho kinase inhibitor. Cell proliferation inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 127243-85-0. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C20H20BrN3O2S. 2HCl, Molecular Weight: 519.3. US Biological Life Sciences. | Worldwide |
| H-89 Dihydrochloride (PKA Inhibitor III, N- [2- ( (p-Bromocinnamyl ) amino) ethyl ]-5-isoquinolinesulfonamid e , 2HCl) | A cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase A (Ki = 48nM). Inhibits other kinases only at much higher concentrations: CaM kinase II (Ki = 29.7uM), casein kinase I (Ki = 38.3uM), myosin light chain kinase (Ki = 28.3uM), protein kinase C (Ki = 31.7uM), and ROCK-II (IC50 = 270nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs) such as GEFI, GEFII, or Epac (exchange protein directly activated by cAMP). Enhances radiation-induced apoptosis in the human cell line BM 13674. Group: Biochemicals. Grades: Highly Purified. CAS No. 127243-85-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
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