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2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID. Product Category: Heterocyclic Organic Compound. CAS No. 5175-14-4. Molecular formula: C9H6N2O3. Mole weight: 190.16. Product ID: ACM5175144. Alfa Chemistry ISO 9001:2015 Certified.
Intermediate in the production of FabI inhibitors. Group: Biochemicals. Alternative Names: Methyl 6-Bromo-2-oxo-1, 2, 3, 4-tetrahydro[1, 8]naphthyridine-3-carboxylate. Grades: Highly Purified. CAS No. 335031-10-2. Pack Sizes: 1g. US Biological Life Sciences.
7-Bromo-4-oxo-1,4-dihydro-[1,5]naphthyridine-2-carboxylic acid ethyl ester. Uses: Designed for use in research and industrial production. CAS No. 1029773-20-3. Molecular formula: C11H9BrN2O3. Mole weight: 297.11. Purity: 0.96. Product ID: ACM1029773203. Alfa Chemistry ISO 9001:2015 Certified.
7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester is a fluoroquinolone derivative used in the preparation of antibacterial agents. Group: Biochemicals. Alternative Names: 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic Acid Ethyl Ester. Grades: Highly Purified. CAS No. 96568-07-9. Pack Sizes: 2.5g. US Biological Life Sciences.
7-Chloro-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester. Group: Biochemicals. Alternative Names: 7-Chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester. Grades: Highly Purified. CAS No. 100491-29-0. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C17H10ClF3N2O3. US Biological Life Sciences.
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1,2,3,4-Tetrahydro-2,6-naphthyridine
1,2,3,4-Tetrahydro-2,6-naphthyridine is used in the synthetic preparation of quinolizidinone carboxylic acid selective M1 allosteric modulators. Group: Biochemicals. Grades: Highly Purified. CAS No. 31786-18-2. Pack Sizes: 5mg, 10mg. Molecular Formula: C8H10N2, Molecular Weight: 134.18. US Biological Life Sciences.
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1,8-Naphthyridin-2-butyric acid
1,8-Naphthyridin-2-butyric acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1,5-Naphthyridine-2-carboxylic acid, 49850-62-6, 1,8-Naphthyridin-2-butyricacid, SureCN841536, Ambpe2020421, CTK4J1769, MolPort-001-760-728, SBB088883, AKOS006344718, PB30868, KB-64596, pyridino[3,2-b]pyridine-2-carboxylic acid, FT-0677427, A12897, I04-5440. Product Category: Heterocyclic Organic Compound. CAS No. 49850-62-6. Molecular formula: C9H6N2O2. Mole weight: 174.16. Purity: 0.96. IUPACName: 1,5-naphthyridine-2-carboxylic acid. Canonical SMILES: C1=CC2=C(C=CC(=N2)C(=O)O)N=C1. Density: 1.421g/cm³. Product ID: ACM49850626. Alfa Chemistry ISO 9001:2015 Certified. Categories: 886362-95-4.
2-Benzylisoindoline-4-carboxylic Acid
2-Benzylisoindoline-4-carboxylic Acid is used in the preparation of 7-(2-Isoindolinyl)-1,4-dihydro-4-oxoquinoline and 1,8-naphthyridine-3-carboxylic Acid derivative as strong anti-bacterial activity against gram negative and positive microorganisms. Group: Biochemicals. Grades: Highly Purified. CAS No. 127169-17-9. Pack Sizes: 25mg, 50mg. Molecular Formula: C16H15NO2, Molecular Weight: 253.3. US Biological Life Sciences.
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3-(Chloromethyl)-6-(trifluoromethyl)pyridine
3-(Chloromethyl)-6-(trifluoromethyl)pyridine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-methyl-1,6-naphthyridine-3-carboxylic acid, 387350-63-2, Peakdale1_000281, PubChem15608, AC1MC6HR, SureCN841350, AC1Q2P9F, Ambpe3000075, CTK1C1930, HMS518M17, MolPort-000-159-659, SBB090748, AKOS006227990, 3-Carboxy-2-methyl-1,6-naphthyridine, AG-L-23153, KB-85192, FT-0676496, 2-Methyl-1,6-naphthyridine-3-carboxylicacid;, 1,6-Naphthyridine-3-carboxylicacid, 2-methyl-, M-2446. Product Category: Heterocyclic Organic Compound. CAS No. 387350-63-2. Molecular formula: C10H8N2O2. Mole weight: 188.19. Purity: 0.96. IUPACName: 2-methyl-1,6-naphthyridine-3-carboxylic acid. Canonical SMILES: CC1=C(C=C2C=NC=CC2=N1)C(=O)O. Density: 1.359g/cm³. Product ID: ACM387350632. Alfa Chemistry ISO 9001:2015 Certified. Categories: 5-(chloromethyl)-2-(trifluoromethyl)pyridine.
Adrenaline Impurity 4
An impurity of Epinephrine. Epinephrine is an endogenous catcholamine with combined α-and β-agonist activity and its principal sympathomimetic hormone is produced by the adrenal medulla. Synonyms: 1-Ethyl-7-chloro-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid ethyl ester; 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester; SCHEMBL3977245. CAS No. 79286-86-5. Molecular formula: C13H12ClFN2O3. Mole weight: 298.70.
Alatrofloxacin Mesylate
Alatrofloxacin Mesylate is the mesylate salt form of the fluoroquinolone derivative Alatrofloxacin, a type II DNA topoisomerase inhibitor that has been developed as an antibacterial agent. Synonyms: L-Alaninamide, L-alanyl-N-[(1α,5α,6α)-3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-, methanesulfonate (1:1); L-Alaninamide, L-alanyl-N-[(1α,5α,6α)-3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-, monomethanesulfonate; L-Alaninamide, L-alanyl-N-[3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-, (1α,5α,6α)-, monomethanesulfonate; Adrenochrome monoaminoguanidine mesilate; CP 116517; CP 116517-27; Trovan IV; Turvel IV; 7-((1R,5S,6s)-6-((S)-2-((S)-2-aminopropanamido)propanamido)-3-azabicyclo[3.1.0]hexan-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid compound with methanesulfonic acid (1:1). Grades: ≥95%. CAS No. 146961-77-5. Molecular formula: C27H29F3N6O8S. Mole weight: 654.61.
Amfonelic acid (AFA; WIN 25,978) is a research chemical and dopaminergic stimulant with antibiotic properties. Synonyms: AMFONELIC ACID; AMFONELIC ACID INCREASES DOPAMINE RE; amfonelic acid (7-benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid); Amfonelic; 7-Benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid; NCA. Grades: 95%. CAS No. 15180-02-6. Molecular formula: C18H16N2O3. Mole weight: 308.33.
Apovincaminic acid
Apovincaminic acid. Group: Biochemicals. Alternative Names: (13aS,13bS)-13a-Ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylic acid; Apovincamin-22-oic acid; (3a,16a)-Eburnamenine-14-carboxylic acid. Grades: Highly Purified. CAS No. 27773-65-5. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C20H22N2O2. US Biological Life Sciences.
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CI 951
CI 951 is a dihydronaphthyridine Ca2+ channel antagonist and it may be applicated for the treatment of focal cerebral ischemia. CI 951 has potential as a cerebral vasodilator. Uses: Focal cerebral ischemia. Synonyms: CI 951; CI-951; CI951. 1,6-Naphthyridine-3-carboxylic acid, 1,4-dihydro-2-methyl-5-(1-methylethoxy)-4-(2-(trifluoromethyl)phenyl)-, ethyl ester. Grades: 98%. CAS No. 126661-07-2. Molecular formula: C22H23F3N2O3. Mole weight: 420.42.
cis-Apovincamine
cis-Apovincamine. Group: Biochemicals. Alternative Names: (3α,16α)-Eburnamenine-14-carboxylic Acid Methyl Ester; 1H-Indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine, eburnamenine-14-carboxylic acid deriv.; (+)-Apovincamine; (+)-cis-Apovincamine; Methyl (3α,16α)-eburnamenine-14-carboxylate; Vinpocetine Related Compound B; (methyl (13aS,13bS)-13a-ethyl-9-methoxy-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2,1-de]-pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate. Grades: Highly Purified. CAS No. 4880-92-6. Pack Sizes: 1mg. Molecular Formula: C21H24N2O2, Molecular Weight: 336.43. US Biological Life Sciences.
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(+)-cis-Vincaminic Acid Ethyl Ester
(+)-cis-Vincaminic Acid Ethyl Ester. Group: Biochemicals. Alternative Names: (3α,14 β,16α)-14,15-Dihydro-14-hydroxyeburnamenine-14-carboxylic Acid Ethyl Ester; 1H-Indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine, eburnamenine-14-carboxylic Acid Deriv.; (+)-Ethyl vincaminate; Ethyl (+)-cis-Vincaminate; Ethyl Vincaminate; Vincaminic Acid Ethyl Ester; Ethyl (12RS,13aSR,13bSR)-13a-Ethyl-12-hydroxy-2,3,5,6,12,13,13a,13b-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate; Vinpocetine Related Compound A. Grades: Highly Purified. CAS No. 40163-56-2. Pack Sizes: 1mg. Molecular Formula: C22H28N2O3, Molecular Weight: 368.47. US Biological Life Sciences.
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CP 99433
CP 99433, a fluoroquinolone derivative, has been found to be a Type II DNA topoisomerase inhibitor that could be probably effective as an antibacterial agent. Synonyms: CP 99433; CP99433; CP-99433. 3-Azabicyclo[3.1.0]hexane, 1,8-naphthyridine-3-carboxylic acid deriv; 1,?8-Naphthyridine-3-carboxylic acid, 7-(6-amino-3-azabicyclo[3.1.0]?hex-3-yl)?-1-cyclopropyl-6-fluoro-1,?4-dihydro-4-oxo-, (1α,?5α,?6α)?-. Grades: 98%. CAS No. 147059-71-0. Molecular formula: C17H17FN4O3. Mole weight: 344.34.
Desmethoxyamino Hydroxy Gemifloxacin
Desmethoxyamino Hydroxy Gemifloxacin. Group: Biochemicals. Alternative Names: 7-(3-(Aminomethyl)-4-hydroxypyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid. Grades: Highly Purified. CAS No. 213672-25-4. Pack Sizes: 10mg. Molecular Formula: C17H18FN4O4, Molecular Weight: 362.36. US Biological Life Sciences.
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(-)-Dihydroapovincaminic Acid Ethyl Ester
(-)-Dihydroapovincaminic Acid Ethyl Ester. Group: Biochemicals. Alternative Names: (12R,13aS,13bS)-13a-Ethyl-2,3,5,6,12,13,13a,13b-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylic Acid Ethyl Ester; (3α, 14α, 16α)-14, 15-dihydroeburnamenine-14-carboxylic Acid Ethyl Ester; 1H-Indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine, eburnamenine-14-carboxylic Acid deriv.; (-)-(14α)-Dihydrovinpocetine; Ethyl 14,15-Dihydroapovincaminate; (Ethyl (12RS,13aRS,13bRS)-13a-ethyl-2,3,5,6,12,13,13a,13b-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate); Vinpocetine Related Compound D. Grades: Highly Purified. CAS No. 57327-92-1. Pack Sizes: 5mg. Molecular Formula: C22H28N2O2, Molecular Weight: 352.47. US Biological Life Sciences.
Worldwide
Enoxacin
A fluororquinolone antibacterial used to treat urinary tract infections and gonorrhea. Group: Biochemicals. Alternative Names: 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic Acid; Enofloxacin; Enofloxacine; Enoksetin; Flumark; NSC 629661; PD 107779; Penetrex. Grades: Highly Purified. CAS No. 74011-58-8. Pack Sizes: 1g. US Biological Life Sciences.
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Enoxacin hydrate
Enoxacin hydrate is a synthetic antibiotic belonging to quinolone carboxylic acid compound. It is bactericidal and has a postantibiotischen effect. It is a broad-spectrum antibacterial agent and inhibited 90% Escherichia coli, Klebsiella sp., Aeromonas sp., Enterobacter spp., Serratia spp., Proteus mirabilis, and Morganella morganii at less than or equal to 0.8 micrograms/ml. Uses: Enoxacin hydrate is bactericidal and has a postantibiotischen effect. it is a broad-spectrum antibacterial agent. Synonyms: Enoxacin sesquihydrate;AT-2266 hydrate;CI-919 hydrate; AT 2266 hydrate;CI 919 hydrate; AT2266 hydrate;CI919 hydrate; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic Acid hydrate. Grades: >98%. CAS No. 84294-96-2. Molecular formula: C30H40F2N8O9. Mole weight: 694.694.
Enoxacin Sesquihydrate
Enoxacin Sesquihydrate. Group: Biochemicals. Alternative Names: 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic Acid Sesquihydrate. Grades: Highly Purified. CAS No. 84294-96-2. Pack Sizes: 5g, 10g, 25g, 50g, 100g. US Biological Life Sciences.
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Ethyl 4-hydroxy-[1,5]naphthyridine-3-carboxylate
Ethyl 4-hydroxy-[1,5]naphthyridine-3-carboxylate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-HYDROXY-[1,5]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER;Ethyl 4-Hydroxy-[1,5]naphthyridine-3-carboxylate. Product Category: Heterocyclic Organic Compound. CAS No. 13801-51-9. Molecular formula: C11H10N2O3. Mole weight: 218.21. Product ID: ACM13801519. Alfa Chemistry ISO 9001:2015 Certified. Categories: Ethyl 4-hydroxy-1,5-naphthyridine-3-carboxylate.
Ethyl 6-bromo-4-chloro-1,5-naphthyridine-3-carboxylate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ethyl 6-bromo-4-chloro-1,5-naphthyridine-3-carboxylate, 1083181-13-8, MolPort-008-155-841, SBB069352, ZINC33359103, AKOS015918531, AJ-85908, AK-29735, DB-024641, KB-202288, FT-0659006, A801844, S14-0224, ethyl 6-bromanyl-4-chloranyl-1,5-naphthyridine-3-carboxylate, 6-bromo-4-chloro-1,5-naphthyridine-3-carboxylic acid ethyl ester. Product Category: Heterocyclic Organic Compound. CAS No. 1083181-13-8. Molecular formula: C11H8BrClN2O2. Mole weight: 315.550420 [g/mol]. Purity: 0.96. IUPACName: ethyl 6-bromo-4-chloro-1,5-naphthyridine-3-carboxylate. Canonical SMILES: CCOC(=O)C1=CN=C2C=CC(=NC2=C1Cl)Br. Density: 1.638 g/cm³. Product ID: ACM1083181138. Alfa Chemistry ISO 9001:2015 Certified.
Finerenone Impurity 29
Finerenone Impurity 29. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid. CAS No. 1050477-45-6. Molecular Formula: C21H21N3O4. Mole Weight: 379.41. Catalog: APB1050477456.
Finerenone Impurity 30
Finerenone Impurity 30. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(4-cyano-2-methoxyphenyl)-5-methoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid. CAS No. 2640280-86-8. Molecular Formula: C20H19N3O4. Mole Weight: 365.38. Catalog: APB2640280868.
Finerenone Impurity 31
Finerenone Impurity 31. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(4-cyano-2-methoxyphenyl)-5-isopropoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid. CAS No. 2640280-87-9. Molecular Formula: C22H23N3O4. Mole Weight: 393.44. Catalog: APB2640280879.
Finerenone Impurity 41
Finerenone Impurity 41. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(4-carbamoyl-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid. Molecular Formula: C21H23N3O5. Mole Weight: 397.42. Catalog: APB06307.
Finerenone Impurity 42
Finerenone Impurity 42. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylic acid. Molecular Formula: C19H17N3O4. Mole Weight: 351.36. Catalog: APB06306.
Finerenone Impurity 47
Finerenone Impurity 47. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(4-carboxy-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid. Molecular Formula: C21H22N2O6. Mole Weight: 398.41. Catalog: APB02071.
Finerenone Impurity 50
Finerenone Impurity 50. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,6-naphthyridine-3-carboxylic acid. Molecular Formula: C21H19N3O4. Mole Weight: 377.39. Catalog: APB06302.
Gemifloxacin-13C2,d2
Third generation fluorinated quinolone antibacterial. Group: Biochemicals. Alternative Names: 7-[3-(Aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid-13C2,d2; SB-265805-13C2,d2; LB-20304-13C2,d2. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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Gemifloxacin Impurity
Gemifloxacin Impurity is an Gemifloxacin impurity, Third generation fluorinated quinolone antibacterial. Synonyms: Desmethoxyamino Hydroxy Gemifloxacin; 7-(3-(Aminomethyl)-4-hydroxypyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid. Grades: > 95%. CAS No. 213672-25-4. Molecular formula: C17H19FN4O4. Mole weight: 362.36.
Gemifloxacin mesilate
Gemifloxacin mesilate. Group: Biochemicals. Alternative Names: 7-[3-(Aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid mesilate; SB-265805 mesilate; LB-20304 mesilate. Grades: Highly Purified. CAS No. 210353-53-0. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C19H24FN5O7S. US Biological Life Sciences.
Worldwide
Gemifloxacin Mesylate
Gemifloxacin mesylate, a fluoroquinolone, is an oral broad-spectrum antibacterial agent that has shown strong activity in vitro against a variety of respiratory tract pathogens for the treatment of mild to moderate pneumonia. Synonyms: 1,8-Naphthyridine-3-carboxylic acid, 7-[(4Z)-3-(aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, monomethanesulfonate; Factive; Floxguard; Gemixa; LB 20304a; SB 265805S; 7-[(4Z)-3-(aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-Naphthyridine-3-carboxylic Acid Monomethanesulfonate; (Z)-Gemifloxacin Mesilate. Grades: ≥95%. CAS No. 210353-53-0. Molecular formula: C19H24FN5O7S. Mole weight: 485.50.
Nalidixic acid
Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of bacterial DNA polymerase (DNA gyrase) and avian myeloblastoma virus reverse transcriptase. Synonyms: NSC-82174; NSC82174; 1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic Acid; 1,4-Dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic Acid; Betaxina; Cybis; Dixiben; Eucistin; NegGram; Nelidix; Wintomylon. Grades: >98%. CAS No. 389-08-2. Molecular formula: C12H12N2O3. Mole weight: 232.24.
Nalidixic Acid, 98+%
Inhibitor of bacterial DNA synthesis. Nalidixic acid is the first of the synthetic quinolone antibiotics. It is a naphthyridone, not a quinolone: its ring structure is a 1,8-naphthyridine nucleus that contains two nitrogen atoms, unlike quinoline, which has a single nitrogen atom.[1] Synthetic quinolone antibiotics were discovered by George Lesher and coworkers as a byproduct of chloroquine manufacture in the 1960s.[1] Used clinically from 1967.[1]. Group: Biochemicals. Alternative Names: 1,4-Dihydro-1-ethyl-7-methyl-1,8-naphthyridin-4-one-3-carboxylic acid; 1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid. Grades: Highly Purified. CAS No. 389-08-2. Pack Sizes: 100g, 250g, 500g, 1Kg. Molecular Formula: C12H12N2O3. US Biological Life Sciences.
Worldwide
Nalidixic Acid 99+%
Inhibitor of bacterial DNA synthesis. Nalidixic acid is the first of the synthetic quinolone antibiotics. It is a naphthyridone, not a quinolone: its ring structure is a 1,8-naphthyridine nucleus that contains two nitrogen atoms, unlike quinoline, which has a single nitrogen atom.[1] Synthetic quinolone antibiotics were discovered by George Lesher and coworkers as a byproduct of chloroquine manufacture in the 1960s.[1] Used clinically from 1967.[1]. Group: Biochemicals. Alternative Names: 1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylicAcid; 1,4-Dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic Acid; Betaxina; Cybis; Dixiben; Eucistin; NegGram; Nelidix; Win 18320; Wintomylon. Grades: Highly Purified. CAS No. 389-08-2. Pack Sizes: 25g, 100g. US Biological Life Sciences.
Worldwide
Nalidixic Acid-d5
Inhibitor of bacterial DNA synthesis. Nalidixic acid is the first of the synthetic quinolone antibiotics. It is a naphthyridone, not a quinolone: its ring structure is a 1,8-naphthyridine nucleus that contains two nitrogen atoms, unlike quinoline, which has a single nitrogen atom.[1] Synthetic quinolone antibiotics were discovered by George Lesher and coworkers as a byproduct of chloroquine manufacture in the 1960s.[1] Used clinically from 1967.[1]. Group: Biochemicals. Alternative Names: 1-(Ethyl-d5)-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic Acid;1,4-Dihydro-1-(ethyl-d5)-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic Acid; Betaxina-d5; Cybis-d5; Dixiben-d5; Eucistin-d5; NegGram-d5; Nelidix-d5; Win 18320-d5; Wintomylon-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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Nalidixic acid sodium salt
Nalidixic acid sodium salt. Group: Biochemicals. Alternative Names: 1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid sodium salt. Grades: Highly Purified. CAS No. 3374-5-8. Pack Sizes: 25g, 50g, 100g, 250g, 500g. Molecular Formula: C12H11N2NaO3. US Biological Life Sciences.
Worldwide
PD 131628
PD 131628 is a new fluoroquinolone as the bioactive form of PD 131112 which is a antibacterial agent originated by Pfizer. PD 131112 can be used for the treatment of infections with penicillin-resistant and -susceptible pneumococci, but no development has been published yet. Uses: Bacterial infections. Synonyms: PD-131628; PD131628; PD 131628; (S)-7-(3-aminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid. Grades: 98%. CAS No. 127967-03-7. Molecular formula: C16H17FN4O3. Mole weight: 332.33.
PD-138312
PD-138312 is a novel broad-spectrum 7-pyrrolidinyl fluoronaphthyridines with a difluorophenyl substitution or a cyclopropyl at the 1 positions, respectively. It has been demonstrated to have excellent therapeutic potential against clinically important gram-positive pathogens in vitro activity. It was evaluated for its in vivo potencies against acute systemic infections and pneumococcal in mice pneumonia model. Uses: Pd-138312 has been demonstrated to have excellent therapeutic potential against clinically important gram-positive pathogens. Synonyms: PD-138312; PD138312; PD 138312;7-(3-(2-Aminopropan-2-yl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid;7-(3-(1-Amino-1-methylethyl)-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid. Grades: >98%. CAS No. 107334-06-5. Molecular formula: C19H23FN4O3. Mole weight: 374.41.
PD 140248
PD 140248, a fluoronaphthyridine compound, has been found to have potential antibacterial effect especially against gram-positive pathogens. It has not been reported about its development status since 2000. Synonyms: PD-140248; PD140248; PD 140248; 7-(3-(1-Aminoethyl)-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid; 1,8-Naphthyridine-3-carboxylic acid, 7-(3-(1-aminoethyl-1-pyrrolidinyl))-1-(2,4-difluorophenyl)-6-fluoro-1,4-d. Grades: 98%. CAS No. 147208-55-7. Molecular formula: C21H19F3N4O3. Mole weight: 432.39.
Silmitasertib
Silmitasertib is an orally bioavailable inhibitor of CK2 with potential antineoplastic activity. It inhibits proliferation in cancer cell lines overexpressing CK2. It suppresses survival and induces apoptosis of cancer stem cells including glioblastomas and acute myeloid leukemia cells. Synonyms: CX-4945; CX 4945; 5-((3-Chlorophenyl)amino)benzo[c][2, 6]naphthyridine-8-carboxylic acid. Grades: >98%. CAS No. 1009820-21-6. Molecular formula: C19H12ClN3O2. Mole weight: 349.774.
T 0156 hydrochloride
T 0156 hydrochloride is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5). T 0156 exhibits higher selectivity than sildenafil (IC50 = 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). Synonyms: 2,7-Naphthyridine-3-carboxylic acid, 1,2-dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-, methyl ester, hydrochloride (1:1); 2,7-Naphthyridine-3-carboxylic acid, 1,2-dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-, methyl ester, monohydrochloride; Methyl 1,2-dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylate hydrochloride (1:1); T0156; T-0156. Grades: ≥99% by HPLC. CAS No. 324572-93-2. Molecular formula: C31H29N5O7.HCl. Mole weight: 620.06.
Tosufloxacin Toluenesulfonate Hydrate
Useful as a therapeutic antimicrobial for the treatment of respiratory infections. Group: Biochemicals. Alternative Names: 7-(3-Amino-1-pyrrolidinyl)-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Toluenesulfonate Hydrate; Tosufloxacin Tosylate; A-64730; T-3262; Ozax; Tosuxacin. Grades: Highly Purified. CAS No. 115964-29-9. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Tosufloxacin tosylate
Tosufloxacin is a fluoroquinolone antibiotic with activity against Gram-positive and Gram-negative aerobic bacteria, anaerobic bacteria and Chlamydia trachomatis. It acts as an inhibitor of bacterial DNA gyrase and topoisomerase IV. Synonyms: Tosuxacin; Ozex; 7-(3-aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid tosylate. Grades: ≥95%. CAS No. 115964-29-9. Molecular formula: C26H23F3N4O6S. Mole weight: 576.543.
Trovafloxacin
Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current. Trovafloxacin does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TROVAFLOXACIN;1,8-Naphthyridine-3-carboxylic acid, 7-(1.alpha.,5.alpha.,6.alpha.)-6-amino-3-azabicyclo3.1.0hex-3-yl-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-;(1α,5α,6α)-7-(6-Amino-3-azabi-cyclo[3.1.0]hex-3-y1)-1-(2,4-difluomphenyl)-6-fluom-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid;CP-99219;Trovan:CP-99219-27;7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-keto-1,8-naphthyridine-3-carboxylic acid;7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid;7-[(1R,5S)-6-azanyl-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid. Product Category: Inhibitors. CAS No. 147059-72-1. Molecular formula: C20H15F3N4O3. Mole weight: 416.35. Product ID: ACM
Trovafloxacin mesylate
Trovafloxacin mesylate is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin mesylate blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin mesylate is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current. Trovafloxacin mesylate does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin mesylate leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 7-[(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Methanesulfonate; CP 99219; CP 99219-27; Trovafloxacin Methanesulfonate; Trovafloxacin Monomethanesulfonate; Trovan. Product Category: Inhibitors. Appearance: White Solid. CAS No. 147059-75-4. Molecular formula: C20H15F3N4O3. Mole weight: 512.46. Purity: >99 %. IUPACName: 7-[(1S,5R)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid; methanesulfonic acid. Canonical SMILES: CS(=O)(=O)O.C1C2C(C2N)CN1C3=C(C=C4C(=O)C(=CN(C4=N3)C5=C(C=C(C=C5)F)F)C(=O)O)F. Density: g/cm³. Product ID: ACM147059754. Alfa Chemistry ISO 9001:2015 Certified.
Trovafloxacin mesylate
Trovafloxacin mesylate is a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current. It does not inhibit connexin 43 gap junction or PANX2. It leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1. It is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. It is also an inhibitor of DNA topoisomerase and gyrase. Uses: Fluorinated quinolone antibacterial. trovafloxacin mesylate blocks the activity of dna gyrase and topoisomerase iv, enzymes essential in the repliction, transcription, and repair of bacterial dna. Synonyms: 7-[(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Methanesulfonate; CP 99219; CP 99219-27; Trovafloxacin Methanesulfonate; Trovafloxacin Monomethanesulfonate; Trovan; 1,8-Naphthyridine-3-carboxylic acid, 7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, methanesulfonate (1:1). Grades: ≥95%. CAS No. 147059-75-4. Molecular formula: C21H19F3N4O6S. Mole weight: 512.46.
Trovafloxacin Mesylate
Fluorinated quinolone antibacterial. Trovafloxacin mesylate blocks the activity of DNA gyrase and topoisomerase IV, enzymes essential in the repliction, transcription, and repair of bacterial DNA. Group: Biochemicals. Alternative Names: 7-[(1α, 5α, 6α)-6-Amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2, 4-difluorophenyl)-6-fluoro-1, 4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic Acid Methanesulfonate; CP 99219; CP 99219-27; Trovafloxacin Methanesulfonate; Trovafloxacin Monomethanesulfonate; Trovan. Grades: Highly Purified. CAS No. 147059-75-4. Pack Sizes: 10mg. US Biological Life Sciences.
An impurity of Vinpocetine. Vinpocetine, isolated from the lesser periwinkle plant, is a derivative of the vinca alkaloid vincamine with an effect of cerebral blood-flow enhancing and neuroprotection. Vinpocetine was approved for the treatment of cerebrovascular disorders and age-related memory impairment in Eastern Europe. Synonyms: Apovincaminic Acid; (13aS,13bS)-13a-Ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylic acid; Apovincamin-22-oic acid; (3a,16a)-Eburnamenine-14-carboxylic acid. CAS No. 27773-65-5. Molecular formula: C20H22N2O2. Mole weight: 322.41.
INCB086550
INCB086550 is A Potent and Novel Small-Molecule PD-L1 Inhibitor. In vitro, INCB086550 selectively and potently blocked the PD-L1/PD-1 interaction, induced PD-L1 dimerization and internalization, and induced stimulation-dependent cytokine production in primary human immune cells. In vivo, INCB086550 reduced tumor growth in CD34+ humanized mice and induced T-cell activation gene signatures, consistent with PD-L1/PD-1 pathway blockade. Preliminary data from an ongoing phase I study confirmed PD-L1/PD-1 blockade in peripheral blood cells, with increased immune activation and tumor growth control. Uses: Designed for use in research and industrial production. Additional or Alternative Names: INCB086550; INCB-086550; INCB 086550; INCB86550; INCB-86550; INCB 86550; PD-1; PD-L1-IN-8. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2230911-59-6. Molecular formula: C41H39N7O4. Mole weight: 693.81. Purity: >98%. IUPACName: 1-((7-cyano-2-(3'-((3-((3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-yl)amino)-2,2'-dimethyl-[1,1'-biphenyl]-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid. Canonical SMILES: CC1=C(C=CC=C1C2=NC3=CC(=CC(=C3O2)C#N)CN4CCC(C4)C(=O)O)C5=C(C(=CC=C5)NC6=NC=CC7=CC(=CN=C76)CN8CCC(C8)O)C. Product ID: ACM2230911596. Alfa Chemistry ISO 9001:2015 Certified.
(+)-ITD-1
(+)-ITD-1 is the (+)-enantiomer of ITD 1 that is more active. ITD-1 is a selective inhibitor of TGFβ/Smad signaling (IC50 values 0.46 μM and 6.90 μM for (+)-ITD 1 and (-)-ITD 1, respectively for TGF-β inhibition) that clears the type II TGFβ receptor from the cell surface. ITD 1 promotes the differentiation of cardiomyocytes and cardiogenesis in murine embryonic stem cell (mESCs). Synonyms: ITD-1; 1099644-42-4; ITD 1; ITD1; ethyl 2,7,7-trimethyl-5-oxo-4-(4-phenylphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxylate; (+)-ITD 1; 1409968-46-2; 4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester; Ethyl 4-([1,1'-biphenyl]-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate; ethyl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate;6-{(1R)-1-[8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H) -one; ethyl 2,7,7-trimethyl-5-oxo-4-(4-phenylphenyl)-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate; ethyl 2,7,7-trimethyl-5-oxo-4-(4-phenylphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate. Grades: 99%. CAS No. 1409968-46-2. Molecular formula: C27H29NO3. Mole weight: 415.52.
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