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1-(5-O-(Dimethoxytrityl)-β-D-2-deoxyribofuranosyl)-4-methylindole is a nucleoside mimic. Its paramount function involves participating in the construction of antiviral pharmacological substances, thus potentially reinforcing the potency against pathological conditions borne from viral incursions. Grades: ≥ 97%. CAS No. 180737-32-0. Molecular formula: C35H35NO5. Mole weight: 549.68.
1-Amino-7-cyclopropylmethyl-7,8-dihydro-8-oxo-9-(b-D-xylofuranosyl)guanine is a remarkable antiviral medication proficient in managing a range of viral infections caused by herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus. Functioning by thwarting viral DNA polymerase and interrupting viral replication, this product exhibits exceptional proficiency in controlling herpes keratitis and encephalitis, as well as treating viral infections in immunocompromised patients. Its unparalleled potential in augmenting the immune response and suppressing pathological viruses results in its widespread application in medicinal microbiology. Synonyms: 1-Amino-7-cyclopropylmethyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine; 1,2-diamino-7-(cyclopropylmethyl)-9-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7,9-dihydro-1H-purine-6,8-dione. Grades: ≥95%. CAS No. 2389988-22-9. Molecular formula: C14H20N6O6. Mole weight: 368.35.
1-Docosahexaenoyl-2-stearoyl-sn-glycero-3-phosphocholine-d9 is labelled 1-Docosahexaenoyl-2-stearoyl-sn-glycero-3-phosphocholine (D494490) which is a glycerophosphocholine degradation product formed from hypochlorous acid attack on vinyl-ether bond of plasmalogens under pathological condition. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C48H75D9NO8P, Molecular Weight: 843.21. US Biological Life Sciences.
Labeled glycerophospholipids act as regulators of various enzyme activities, and can be used as biological markers to indicate pathological states. Group: Biochemicals. Alternative Names: [R- (Z) ]-4-Hydroxy-N, N, N-trimethyl-9-oxo-7-[[ (1-oxohexadecyl) oxy]methyl]-3, 5, 8-trioxa-4-phosphahexacos-17-en-1-aminium 4-Oxide-13C16; POPC-13C16. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Labeled glycerophospholipids act as regulators of various enzyme activities, and can be used as biological markers to indicate pathological states. Group: Biochemicals. Alternative Names: R- (Z) ]-4-Hydroxy-N, N, N-trimethyl-9-oxo-7-[[ (1-oxohexadecyl) oxy]methyl]-3, 5, 8-trioxa-4-phosphahexacos-17-en-1-aminium 4-Oxide-13C18; POPC-13C18. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
2-Amino-2'-O-(2-methoxy-2-oxoethyl)adenosine
2-Amino-2'-O-(2-methoxy-2-oxoethyl)adenosine is renowned for its exceptional potency and remarkable affinity for the adenosine A2A receptors, making it stand out as an exquisite adenosine agonist. Distinguished by its profound neuroprotective attributes and anti-inflammatory characteristics, it offers unprecedented avenues for exploration regarding the intricate role adenosine receptors play in both physiological and pathological realms alike. Synonyms: Methyl 2-(((2R,3R,4R,5R)-2-(2,6-diamino-9H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)acetate; Adenosine, 2-amino-2'-O-(2-methoxy-2-oxoethyl)-. Grades: ≥95%. CAS No. 433288-71-2. Molecular formula: C13H18N6O6. Mole weight: 354.32.
2-Amino-3'-O-methyladenosine
2-Amino-3'-O-methyladenosine, a versatile biomolecule, exhibits promising therapeutic potential in tackling a myriad of pathological conditions, ranging from malignant neoplasms to infectious disorders and inflammatory ailments, and has garnered immense attention as a vital investigative probe for exploring the intricate roles of RNA methylation. Emerging evidence points to the multifaceted role of 2-Amino-3'-O-methyladenosine in impeding tumorigenesis, abating viral propagation, and modulating immune reactivity, thus underscoring its indispensable relevance in the biomedical arena. Synonyms: (2R,3R,4S,5R)-2-(2,6-diamino-9H-purin-9-yl)-5-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol; Adenosine, 2-amino-3'-O-methyl-; 2,6-Diaminopurine-3'-O-methyl-riboside; 3'-OMe-2-NH2-A. Grades: ≥95%. CAS No. 80791-88-4. Molecular formula: C11H16N6O4. Mole weight: 296.28.
2'-Deoxy-2'-fluoro-N3-[3-(tert-butoxycarbonyl)amino]propyluridine, a biomedical compound extensively employed in combating a plethora of pathological conditions, assumes a paramount role in thwarting the reproduction and dissemination of malignant agents. Furthermore, it showcases promising antiviral attributes against distinct viral variants, thus emerging as a plausible therapeutic contender for combating viral afflictions. Grades: ≥95%. Molecular formula: C17H26FN3O7. Mole weight: 403.40.
2'-Deoxy-5'-O-DMT-N6-phenoxyacetyladenosine
2'-Deoxy-5'-O-DMT-N6-phenoxyacetyladenosine is a highly potent compound utilized extensively within the biomedical sector, notably employed in discerning drug discovery and specialized therapeutic interventions. This instrumental entity boasts an intricate composition and inherent characteristics, rendering it invaluable for investigating the intricate functionality of adenosine receptors and their prospective manipulation in mitigating specific pathological conditions. Synonyms: 2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-N6-phenoxyacetyladenosine; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-phenoxyacetyl)adenosine; 2'-Deoxy-5'-O-DMT-N6-phenoxyacetyl-D-adenosine; 5'-ODMT-N6-phenoxyacetyl-2'-deoxyadenosine; N- (9- ( (2R, 4S, 5R)-5- ( (bis (4-methoxyphenyl) (phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)-2-phenoxyacetamide; Pheac-Dmt-Deoxyadenosine. Grades: ≥95%. CAS No. 110522-82-2. Molecular formula: C39H37N5O7. Mole weight: 687.74.
2'-Deoxy-N6-(4-methoxybenzyl)adenosine
2'-Deoxy-N6-(4-methoxybenzyl)adenosine is a vital compound extensively utilized in the field of biomedical research, manifesting as a formidable inhibitory agent targeting specific enzymes and receptors implicated in diverse pathological conditions. Synonyms: (2R,3S,5R)-2-(hydroxymethyl)-5-[6-[(4-methoxyphenyl)methylamino]purin-9-yl]oxolan-3-ol. Grades: ≥95%. CAS No. 157640-47-6. Molecular formula: C18H21N5O4. Mole weight: 371.39.
2'-Deoxy-N6-phenoxyacetyladenosine
2'-Deoxy-N6-phenoxyacetyladenosine, a remarkable compound widely employed in the field of biomedicine, serves as a valuable research tool for investigating and advancing therapeutic interventions in diverse pathological conditions. With its exceptional chemical architecture, this compound exhibits promising capabilities in selectively engaging receptors linked to inflammatory processes, tumorigenesis, and viral afflictions. Synonyms: 2'-Deoxy-N6-phenoxyacetyl-D-adenosine; N6-Phenoxyacetyl-2'-deoxyadenosine; N-(9-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)-2-phenoxyacetamide. Grades: ≥95%. CAS No. 110522-74-2. Molecular formula: C18H19N5O5. Mole weight: 385.37.
2'-Deoxy-O6-[2-(4-nitrophenylethyl)]guanosine
2'-Deoxy-O6-[2-(4-nitrophenylethyl)]guanosine is a highly renowned compound with exceptional affinity towards specialized receptors and enzymes. Empowered by its distinctive chemical configuration, this compound exhibiting unparalleled competence in precisely engaging specific cellular cascades implicated in diverse pathological conditions. Synonyms: 6-[(4-Nitrophenethyl)oxy]-9-(2-deoxy-beta-D-erythro-pentofuranosyl)-9H-purine-2-amine; (2R,3S,5R)-5-(2-Amino-6-(4-nitrophenethoxy)-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol; 2'-Deoxy-6-O-[2-(4-nitrophenyl)ethyl]guanosine; 9-(2-Deoxy-β-D-erythro-pentofuranosyl)-6-[2-(4-nitrophenyl)ethoxy]-9H-purin-2-amine. Grades: ≥95%. CAS No. 86137-72-6. Molecular formula: C18H20N6O6. Mole weight: 416.39.
2-Ethynyl-ATP (2-EATP)
2-Ethynyl-ATP (2-EATP), a modified nucleotide, finds its utility in enzymatic assays intended to scrutinize ATP-binding proteins, namely kinases and phosphatases. It also serves as a powerful instrument to investigate ATP-dependent enzymes implicated in numerous pathological conditions, viz. cancer and neurological disorders. Synonyms: 2-Ethynyl-adenosine-5'-triphosphate, Sodium salt. Grades: ≥ 90% by HPLC, contains approx. 6% 2-Ethynyl-ADP. Molecular formula: C12H16N5O13P3. Mole weight: 531.2.
3'-beta-C-Methyl-N6-(m-trifluoromethylbenzyl)adenosine is a highly potent adenosine receptor agonist, exhibiting exceptional selectivity. Its versatility is evident in its ability to regulate intricate cellular signaling cascades implicated in diverse pathological conditions encompassing inflammation, malignancies, and neurological afflictions. Synonyms: 3'-C-Methyl-N6-(m-trifluoromethylbenzyl)adenosine. Grades: ≥95%. Molecular formula: C19H20F3N5O4. Mole weight: 439.39.
3-Bromomethyl-2,5-dihydrothiophene-1,1-dioxide
3-Bromomethyl-2,5-dihydrothiophene-1,1-dioxide acts as a reagent for the synthetic preparation of gelsemine used for pathological anxiety. Group: Biochemicals. Grades: Highly Purified. CAS No. 31554-48-0. Pack Sizes: 10mg, 25mg. Molecular Formula: C5H7BrO2S, Molecular Weight: 211.08. US Biological Life Sciences.
Worldwide
3'-Deoxy-N6-isopentenyladenosine
3'-Deoxy-N6-isopentenyladenosine, a formidable antioxidant and immunomodulatory agent, holds immense prospects in the biomedical field. Its compelling efficacy has been evidenced in diverse pathological states such as cancer, neurodegenerative disorders, and autoimmune diseases. Synonyms: 3'-Deoxy riboprine; 6-(3-methyl-2-butenylamino)-9-(3'-deoxy-β-D-ribofuranosyl)purine; (2R,3R,5S)-5-(hydroxymethyl)-2-[6-(3-methylbut-2-enylamino)purin-9-yl]oxolan-3-ol; 3'-Deoxy-N-(3-methyl-2-buten-1-yl)adenosine. Grades: ≥95%. CAS No. 1237496-62-6. Molecular formula: C15H21N5O3. Mole weight: 319.36.
3-O-(2-Acetamido-2-deoxy-α-D-glucopyranosyl)-D-galactose, an indispensable compound in the biomedical realm, displays immense potential for treating a multitude of diseases. Its effectiveness in countering bacterial infections and impeding microbial proliferation is remarkable. Furthermore, scholarly investigations propose that this compound holds promise in the creation of innovative therapeutics designed to target distinct pathological states. Its multifaceted nature and intricate molecular structure contribute to its significance in scientific research and its profound impact on the biomedical field. Synonyms: GlcNAc-a-(1-3)-Gal. Grades: 95%. CAS No. 97096-73-6. Molecular formula: C14H25NO11. Mole weight: 383.35.
4-Methylumbelliferyl 3,6-Di-O-benzoyl-β-D-galactopyranoside, a highly specialized biomedicine compound, exemplifies an invaluable tool for evaluating and quantifying β-galactosidase activity. Its multifaceted utilization spans a myriad of research endeavors and diagnostic protocols to unveil the intricacies surrounding the expression and functionality of this pivotal enzyme. By shedding light on the physiological and pathological dimensions intertwined with β-galactosidase-related disorders, notably lysosomal storage diseases, this product unfurls boundless avenues for comprehensive comprehension in scientific spheres. Grades: 98%. Molecular formula: C30H26O10. Mole weight: 546.52.
5-Azido-PEG4-dCTP
5-Azido-PEG4-dCTP is an indispensible recompound in the realm of biomedical sciences, finding its utility in cutting-edge research and diagnostic procedures. Predominantly employed in an assortment of molecular biology methodologies including polymerase chain reaction (PCR) and deoxyribonucleic acid (DNA) sequencing, this remarkable compound empowers targeted labeling and identification of nucleic acids crucial for drug exploration, genetic analysis and comprehension of pathological pathways. Synonyms: 5-Azido-PEG4-2'-deoxycytidine-5'-triphosphate, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C23H38N7O18P3 (free acid). Mole weight: 793.51 (free acid).
5'-O-DMT-thymidine 3'-thiophosphoramidite
5'-O-DMT-thymidine 3'-thiophosphoramidite, a highly indispensable reagent employed in numerous biomedical applications, has the capability to confer augmented stability and safeguard the resultant sequences against degradation by nucleases. Its employment facilitates the precise introduction of 5'-O-DMT-thymidine into the oligonucleotide chain, thereby enabling focused therapeutic interventions for drug administration, gene suppression, and pathological condition detection. Synonyms: 5'-Dimethoxytrityl-2'-deoxythymidine 3'-[(B-thiobenzoylethyl)-(1-pyrrolidinyl)]-thiophosphoramidite; dT-Thiophosphoramidite. Grades: 90%. Molecular formula: C44H48N3O8PS2. Mole weight: 841.97.
5-Propargylamino-dCTP - Texas Red
5-Propargylamino-dCTP - Texas Red is a highly acclaimed recompound in biomedical research, serving as an invaluable resource for both molecular labeling and imaging applications. With its intricate nucleotide derivative, this prodigious innovation finding extensive utility in DNA labeling and sequencing assays, facilitating expedited detection and analysis of DNA replication, transcription and repair phenomena. Notably, its seamless compatibility with the illustrious Texas Red fluorescent dye confers unparalleled sensitivity and specificity, thereby enabling the visualization of intricate cellular activities and discernment of pathological alterations. Synonyms: 5-Propargylamino-2'-deoxycytidine-5'-triphosphate, labeled with Texas Red, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C49H58N7O20P3S2 (free acid). Mole weight: 1222.07 (free acid).
6-Benzylaminopurine 9-(β-D-glucoside)
6-Benzylaminopurine 9-(β-D-glucoside) is a highly sought-after compound in the biomedical sector, widely utilized for research of a myriad of ailments, including cancer, cardiovascular afflictions and inflammatory maladies. This substance manifests formidable antimetastatic effects while intricately modulating cascades critical for pathological development. Synonyms: N6-Benzyladenine 9-Glucoside. Grades: 95%. CAS No. 4294-17-1. Molecular formula: C18H21N5O5. Mole weight: 387.39.
7-Deaza-dGDP
7-Deaza-dGDP is a highly intricate and substantial element with the application as an invaluable tool for examining the intricacies of RNA-dependent RNA polymerases and their pivotal involvement in diverse pathological conditions, particularly those concerning viral afflictions. Synonyms: 7-Deaza-2'-deoxyguanosine-5'-diphosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C11H16N4O10P2 (free acid). Mole weight: 426.21 (free acid).
7-Propargylamino-7-deaza-ddGTP - 6-ROX
7-Propargylamino-7-deaza-ddGTP - 6-ROX is an indispensable entity prevalent in the realm of biomedicine, catering to the inexorable world of high-throughput sequencing and DNA fragment analysis. Its distinctive attributes galvanize researchers, enabling them to scrutinize diverse strands of DNA across multifarious spheres, including pharmacological exploration, genomic inquiry is and pathological elucidations. Moreover, it has efficaciously facilitated the reprehension of drug-induced perturbations in DNA replication, while concurrently unearthing the ramifications of malignancies on the delicate tapestry of DNA. Synonyms: 7-Deaza-7-propargylamino-2',3'-dideoxyguanosine-5'-triphosphate, labeled with 6-ROX, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C47H48N7O16P3 (free acid). Mole weight: 1059.85 (free acid).
ATTO-390 - 8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate is an esteemed fluorescent probe of singular power, attuned specifically for the observation and identification of mRNA and DNA molecules in medical research. Its virtues extend as well to the understanding of complicated pathological syndromes related to metabolism of nucleic acids, such as cancer, genetic disorders, and infectious diseases. Given its exquisite sensitivity and specificity, ATTO-390 is a scientific instrument unparalleled in exploring and defining the intricacies of cellular pathways, and laying bare hitherto unknown therapeutic possibilities. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate, labeled with ATTO 390, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C36H52N8O13P2 (free acid). Mole weight: 866.80 (free acid).
8-[(6-Amino)hexyl]-amino-adenosine-3',5'-bisphosphate - DY-751 is a highly potent and selective small molecule compound meticulously designed for cutting-edge biomedical applications. Deploying an ingenious mechanism of action, it astutely intervenes with adenosine receptors, thereby orchestrating a precise and nuanced modulation of cellular signaling pathways vital to an array of physiological and pathological processes. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-bisphosphate, labeled with DY 751, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C58H79N9O18P2S2 (free acid). Mole weight: 1315.46 (free acid).
8-[(6-Amino)hexyl]-amino-cAMP - ATTO-580Q
8-[(6-Amino)hexyl]-amino-cAMP - ATTO-580Q, a fluorescent tracer molecule with immense potential, finds its use in the biomedical industry for studying cAMP signaling pathways. By enabling the tracing of distribution and activity of cAMP-dependent enzymes, and understanding cAMP's impact on deadly diseases such as cancer and cardiovascular disorders, this product aims to facilitate extensive research. By enhancing our comprehension of cellular signaling, it could offer novel therapies to combat pathological conditions. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-cyclic monophosphate, labeled with ATTO 580Q, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O6P - ATTO 580Q (free acid). Mole weight: 1119.39 (free acid).
8-[(6-Amino)hexyl]-amino-cGMP - ATTO-Rho12
8-[(6-Amino)hexyl]-amino-cGMP - ATTO-Rho12, a fluorescent nucleotide analog, is a versatile and indispensable tool utilized in biomedical research for the monitoring of nitric oxide signaling and cGMP. Its exceptional ability to act as a molecular probe in investigating spatiotemporal dynamics of cGMP signals and their correlation with physiological and pathological processes such as vasodilation, neurotransmission, and various cancers has been a game-changer in the scientific community. This product is essential for any researcher looking to make groundbreaking discoveries and uncover the secrets of these vital signaling pathways. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO Rho12, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C57H75N10O10P (free acid). Mole weight: 1090.54 (free acid).
8-[(6-Amino)hexyl]-amino-cGMP - Cy5
8-[(6-Amino)hexyl]-amino-cGMP - Cy5 is a state-of-the-art biomedical innovation, serving the purpose of visualizing and tracing the intricate signaling pathway of cGMP within living cells. Harnessing the power of fluorescent dye Cy5, this revolutionary creation facilitates dynamic, real-time surveillance of cGMP signaling. This holistic understanding of cGMP's involvement in an array of physiological and pathological phenomena, including cardiovascular disorders, pulmonary hypertension is and erectile dysfunction, renders this compound an indispensable tool for rigorous scientific inquiry and medical investigations. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with Cy5, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C49H64N9O14PS2 (free acid). Mole weight: 1098.19 (free acid).
8-[(6-Amino)hexyl]-amino-cGMP - DY-751
DY-751, a mighty stimulator of cGMP-dependent protein kinase (PKG), is a critical element in deciphering PKG's influence on a miscellany of physiological and pathological mechanisms, encompassing but not limited to vasodilation and platelet cohesion. Additionally, DY-751 plays a pivotal role in the exploration of treatments for life-threatening disorders such as hypertension and heart failure. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with DY 751, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C58H76N9O15PS2 (free acid). Mole weight: 1233.46 (free acid).
8-[(6-Amino)hexyl]-amino-GTP - ATTO-495
8-[(6-Amino)hexyl]-amino-GTP - ATTO-495 serves as a potent fluorescent probe to investigate the sub-cellular localization and functional dynamics of GTP-binding proteins within pathological environments. As such, this dynamic dye represents a valuable tool for elucidating the role of GTP-dependent pathways in disease states, including both degenerative and neoplastic conditions. With applications spanning multiple fields of biomedical research, this sophisticated probe facilitates a comprehensive understanding of molecular mechanisms underlying GTP metabolism. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with ATTO 495, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C37H53N10O15P3 (free acid). Mole weight: 970.80 (free acid).
8-pMeOPT-Ado
8-pMeOPT-Ado is a remarkably potent and preferential activator of adenosine receptors, has established itself as an indispensable tool within the realm of biomedical investigation. This exquisite compound serving as an unrivaled agent for deciphering the intricate involvements of adenosine receptors in multifarious pathological states, encompassing cardiac afflictions, inflammatory cascades is as well as neurodegeneration. Synonyms: 8- (4- Methoxyphenylthio)adenosine. Grades: ≥ 97 % by HPLC. CAS No. 696674-66-8. Molecular formula: C17H19N6O6S. Mole weight: 406.4.
Aluminum Ammonium Sulfate Dodecahydrate
Aluminum Ammonium Sulfate Dodecahydrate is a potent matrix metalloproteinase inhibitor which are key regulators for many pysiological and pathological functions. It is also used in the preparation of antiperspirants and deodorants containing ammonium alum that prevents body odor in humans. Group: Biochemicals. Grades: Highly Purified. CAS No. 7784-26-1. Pack Sizes: 50g, 100g. Molecular Formula: Al (H3N) 2(H2O4S) 12(H2O), Molecular Weight: 26.9817032980812. US Biological Life Sciences.
Worldwide
AppNH2
AppNH2 is indispensable in research of combating ailments including cancer, diabetes is and autoimmune disorders. This revolutionary creation assuming the role of both a mighty inhibitor and a formidable activator, skillfully honing in on crucial proteins and enzymes entangled in the labyrinthine pathways of pathological advancement. Profoundly effective is appNH2 harnesses its exceptional chemical attributes to govern intricate cellular dynamics, thereby fostering optimal physiological harmony. Synonyms: (AMPPN); Adenosine-5'-(β-amido)diphosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C10H16N6O9P2 (free acid). Mole weight: 426.21 (free acid).
Bevonium methylsulfate
Bevonium methylsulfate (CG-201) is an injection that stimulates antibodies to block the pathological forms of hCG that help cancer cells grow and evade the immune system. CG201 was originally created in collaboration with the World Health Organization as a low-cost contraceptive method for developing countries. CG201 is now approved for a Phase I clinical trial in Sweden. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: CG-201; CG 201; CG201; Bevonium methyl sulfate; Piribenzil methyl sulfate; 2-((2-hydroxy-2,2-diphenylacetoxy)methyl)-1,1-dimethylpiperidin-1-ium methyl sulfate. Grades: 98%. CAS No. 5205-82-3. Molecular formula: C23H31NO7S. Mole weight: 465.56.
Bifendate Impurity B
Bifendate Impurity B is an impurity of Bifendate, a potent therapeutic agent treating chronic hepatitis B. Esteemed for its antiviral prowess and hepatic safeguards, Bifendate efficaciously assuages liver inflammation and diminishes the viral burden inherent in patients afflicted with this pathological viral infestation. Grades: > 95%. CAS No. 128142-41-6. Molecular formula: C18H16O9. Mole weight: 376.32.
BMS-986120
BMS-986120, an imidazoles derivative, has been found to be a PAR4 antagonist that could probably be effective against thrombus propagation and pathological vascular occlusion. It was just completed a Phase I trail in in Thrombosis. Synonyms: BMS-986120; BMS 986120; BMS986120; 4-(4-(((6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-yl)oxy)methyl)-5-methylthiazol-2-yl)morpholine. Grades: 98%. CAS No. 1478712-37-6. Molecular formula: C23H23N5O5S2. Mole weight: 513.59.
BW 755C
Constitutive cyclooxygenase (COX-1) is present in cells under physiological conditions, whereas COX-2 is induced by some cytokines, mitogens, and endotoxin in pathological conditions, such as inflammation. Since 5-lipoxygenase (5-LO) oxidizes arachidonic acid to 5-hydroperoxyeicosatetraenoic acid. BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways. It inhibits 5-LO with IC50s of 0.75 μM, COX-1 with IC50s of 0.65 μg/ml, and COX-2 with IC50s of 1.2 μg/ml. BW 755C may also inhibit other LO pathways in vivo. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: BW755C; BW-755C; 1H-Pyrazol-3-amine, 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-; 4,5-Dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine; 1-(3-Trifluoromethylphenyl)-4,5-dihydro-1H-pyrazol-3-amine; 3-Amino-1-[3-(trifluoromethyl)phenyl]-2-pyrazoline; 3-Amino-1-[3-(trifluoromethyl)phenyl]pyrazoline; 3-Amino-1-[m-(trifluoromethyl)phenyl]-2-pyrazoline; Compound BW 755C. Grades: ≥95%. CAS No. 66000-40-6. Molecular formula: C10H10F3N3. Mole weight: 229.20.
BYK 191023 dihydrochloride
BYK 191023 dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS) (IC50 = 86, 17000, 162000 nM for iNOS, nNOS and eNOS, respectively) acting in a NADPH- and time-dependent manner. BYK 191023 decreases the nitrite levels in rats, and reverses pathological hypotension in the rodent endotoxin model. Synonyms: BYK191023 Dihydrochloride; BYK-191023 Dihydrochloride; BYK 191023 Dihydrochloride; BYK191023 2HCl; BYK-191023 2HCl; BYK 191023 2HCl;; 2-[2-(4-Methoxy-2-pyridinyl)ethyl]-1H-imidazo[4,5-b]pyridine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 1216722-25-6. Molecular formula: C14H14N4O.2HCl. Mole weight: 327.21.
C24:1 Mono-sulfo galactosyl (alpha) ceramide (d18:1/24:1) Ammonium salt
C24:1 Mono-sulfo galactosyl (alpha) ceramide (d18:1/24:1) Ammonium salt is a valuable compound serving as a formidable biomarker facilitating the comprehensive investigation of ceramide involvement in diverse pathological conditions, spanning from malignancies such as cancer, to metabolic disorders like diabetes is and even neurodegenerative ailments. Synonyms: 3-O-Sulfo-D-galactosyl-alpha-1,1'-N-Nervonoyl-D-erythro-sphingsoine (ammonium salt); 3-O-sulfo-alpha-D-C24:1-galactosylceramide (ammonium salt); ammonium (2S,3R,4S,5S,6R)-3,5-dihydroxy-2-(((2S,3R,E)-3-hydroxy-2-((Z)-tetracos-15-enamido)octadec-4-en-1-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl sulfate; Ammonium (2S,3R,4E)-3-hydroxy-2-[(15Z)-15-tetracosenoylamino]-4-octadecen-1-yl 3-O-sulfonato-α-D-threo-hexopyranoside. Grades: >99%. CAS No. 2260670-38-8. Molecular formula: C48H94N2O11S. Mole weight: 907.33.
CDK9-IN-1
Among CDKs, CDK9 is a validated pathological target in HIV infection, inflammation and cardiac hypertrophy; however selective CDK9 inhibitors are still not available. We present a selective inhibitor family of CDK9 based on the 4-phenylamino-6- phenylpyrimidine nucleus. We show a convenient synthetic method to prepare a useful intermediate and its derivatisation resulting in novel compounds. The CDK9 inhibitory activity of the derivatives was measured in specific kinase assay and the CDK inhibitory profile of the best ones (IC50 > 100nM) was determined. The most selective compounds had high selectivity over CDK1, 2, 3, 5, 6, 7 and showed at least one order of magnitude higher inhibitory activity over CDK4 inhibition. The most selective molecules were examined in cytotoxicity assays and their ability to inhibit HIV-1 replication was determined in cellular assays. Synonyms: CDK9-IN-1; CDK9 IN 1. Grades: >98%. CAS No. 1415559-43-1. Molecular formula: C26H21N5O4S. Mole weight: 499.54.
Chebulagic acid
Chebulagic acid is a polyphenol and tannin that has been found in T. chebula and has diverse biological activities. It is an inhibitor of COX-1, COX-2, and 5-lipoxygenase (5-LO; IC50s = 15, 0.92, and 2.1 μM, respectively) as well as α-glucosidase and 15-LO (IC50s = 0.05 and 24.9 μM, respectively). Chebulagic acid inhibit the LPS-induced upregulation of TNF-α and IL-1β in a dose- and time-dependent manner. And it can also inhibit the production of NO, prostaglandin E2 (PGE2), and reactive oxygen species (ROS), and nuclear translocation of NF-κB in RAW 264.7 macrophages in a concentration-dependent manner. Chebulagic acid also show a protective effect against 1-methyl-4-phenylpyridinium (MPP+) - induce cytotoxicity which mimics the pathological symptom of Parkinson's disease. Uses: Topoisomerase i inhibitors. Synonyms: β-D-glucopyranose; Cyclic 3,6-[(1R)-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate] 1-(3,4,5-trihydroxybenzoate); Cyclic 2?2:4?1-ester with (2S)-2-[(3S,4S)-5-carboxy-3,4-dihydro-3,7,8-trihydroxy-2-oxo-2H-1-benzopyran-4-yl]butanedioic acid. Grades: ≥98%. CAS No. 23094-71-5. Molecular formula: C41H30O27. Mole weight: 954.66.
EDA-GTPγS - 6-ROX
EDA-GTPγS - 6-ROX, a biochemical substance, is a promising tool for investigating G protein-coupled receptor (GPCR) signaling pathways. Possessing the ability to evaluate G protein activation kinetics by various ligands, it showcases its pivotal role in the study of pathological conditions that implicate GPCR signaling, namely cardiovascular and cancerous diseases. The compound's potent analytical capacity enables researchers to identify and profile the intricacies of these cascades, thereby providing novel insights into the mechanisms behind drugs targeting these pathways. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-guanosine-5'-(γ-thio)-triphosphate, labeled with 6-ROX, Triethylammonium salt. Grades: ≥ 90 % by HPLC, contains approx. 5 % EDA-GDP-dye. Molecular formula: C46H50N9O18P3S (free acid). Mole weight: 1141.93 (free acid).
EDA-m7GTP - Cy3
EDA-m7GTP - Cy3 is a widely employed nucleotide analog, exhibiting fluorescence labeling and finding extensive application, specifically for the investigation of mRNA and RNA metabolism. By integrating seamlessly into RNA transcripts during the transcription process, this remarkable compound enables the visualization and monitoring of RNA molecules within cells. Its utility shines particularly bright in the analysis of mRNA stability, RNA processing, as well as RNA-protein interactions across diverse cellular events and pathological conditions. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-7-methyl-guanosine-5'-triphosphate, labeled with Cy3, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C45H60N9O22P3S2(free acid). Mole weight: 1236.05 (free acid).
Edoxaban
Edoxaban is an oral factor Xa (FXa) inhibitor, also contraindicated in patients with active pathological bleeding. Uses: A direct factor xa inhibitor. Synonyms: DU-176; DU 176; DU176DU-176b;N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide. Grades: ≥98%. CAS No. 480449-70-5. Molecular formula: C24H30CLN7O4S. Mole weight: 548.06.
Edoxaban TsOH salt
Edoxaban is an oral factor Xa (FXa) inhibitor, also contraindicated in patients with active pathological bleeding. Uses: A direct factor xa inhibitor. Synonyms: Edoxaban Tosylate; N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide;4-methylbenzenesulfonic acid. Grades: ≥98%. CAS No. 480449-71-6. Molecular formula: C31H38ClN7O7S2. Mole weight: 720.26.
γ-(6-Aminohexyl)-ATP - ATTO-633
γ-(6-Aminohexyl)-ATP - ATTO-633, a fluorescent probe that finds its application in the domain of biomedical research to examine ATP metabolism and transportation in cells, comes as an optimal choice. Moreover, it serves as a competent agent in monitoring fluctuations arising from internal ATP levels in response to diseases and drugs, exhibiting a high degree of sensitivity and specificity thereby rendering it a valuable asset in exploring the functional aspects of ATP concerning physiological and pathological processes. Synonyms: γ-(6-Aminohexyl)-adenosine-5'-triphosphate, labeled with ATTO 633, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C16H29N6O13P3- ATTO 633 (free acid). Mole weight: 1139.35 (free acid).
γ-(6-Aminohexyl)-GTP - ATTO-580Q
γ-(6-Aminohexyl)-GTP - ATTO-580Q, a fluorescent probe employed in biomedical research, is an efficacious tool for investigating GTPases, the vital regulators in various cellular processes. With the potential to monitor and visualize the GTPases activity, the probe provides unique insights into the pathological conditions like cancer and neurodegenerative disorders, thus enabling better comprehension of their underlying mechanisms. Synonyms: γ-(6-Aminohexyl)-guanosine-5'-triphosphate, labeled with ATTO 580Q, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C16H29N6O14P3- ATTO 580Q (free acid). Mole weight: 1298.35 (free acid).
γ-[(6-Aminohexyl)-imido]-ATP
γ-[(6-Aminohexyl)-imido]-ATP, a potent and selective agonist of the P2Y12 receptor subtype, plays a crucial role in platelet activation and aggregation. Its significance lies not only in the development of novel antiplatelet drugs but also in unveiling the physiological and pathological roles of P2Y12 receptor signaling in platelets and other cells. The versatility of this compound makes it indispensable for scientific research and medical advancement alike. Synonyms: γ-[(6-Aminohexyl)-imido]-adenosine-5'-triphosphate. Grades: ≥ 95 % by HPLC. Molecular formula: C16H30N7O12P3(free acid). Mole weight: 605.37 (free acid).
γ-[(6-Azidohexyl)-imido]-ATP
γ-[(6-Azidohexyl)-imido]-ATP, bestowed with intriguing compound, propelling an astute exploration encompassing ATPase activity and nucleotide-binding entities. Remarkably, this polymorphic compound orchestrates a profound examination concerning pharmaceutical interplay, protein-protein amity and enzymatic machinations, dynamically propelling the frontier of therapeutic evolution and pathological research. Synonyms: γ-[(6-Azidohexyl)-imido]-adenosine-5'-triphosphate. Grades: ≥ 95 %. Molecular formula: C16H28N9O12P3(free acid). Mole weight: 631.37 (free acid).
Glycyl-6'-sialyllactose
Glycyl-6'-sialyllactose, a bioactive compound renowned in the biomedical sector for its immense therapeutic prospects, exhibits exceptional complexity and variability that sets it apart. Remarkably, this novel entity showcases unparalleled potential in combating a plethora of ailments encompassing viral infestations, inflammatory irregularities, and specific malignancies. Functionally, it magnificently zeroes in on precise cellular receptors, effectively modulates immune reactions, and effectively hampers pathological courses. Synonyms: Glycyl-6'-sialyllactose (6'-SL-gly); Neu5Acα2-6Galβ1-4Glc-Gly-NH2. Grades: 95%. Molecular formula: C25H43N3O19. Mole weight: 689.62.
Glycyl-lacto-N-neotetraose
Glycyl-lacto-N-neotetraose is a bioactive compound, indispensable in studying an array of gastrointestinal ailments. This remarkable product serves as a pivotal prebiotic compound finding applications in studying gut vitality, fortifying immunological responses and mitigating the susceptibility to sundry pathological conditions. Synonyms: Glycyl-lacto-N-neotetraose (LNnT-gly); Galβ1-4GlcNAcβ1-3Glaβ1-4Glc-Gly-NH2. Grades: 95%. Molecular formula: C28H49N3O21. Mole weight: 763.70.
Gly-Pro-pNA TosOH
Very good substrate for the assay of dipeptidyl amino-peptidase IV (X-prolyldipeptidyl aminopeptidase), especially in normal and pathological human sera. Synonyms: Glycyl-L-proline 4-nitroanilide 4-toluenesulfonate. Grades: ≥ 99% (TLC, HPLC). CAS No. 65096-46-0. Molecular formula: C13H16N4O4·C7H8O3S. Mole weight: 464.50.
L-Nonaguluronic Acid Nonasodium Salt
L-Nonaguluronic Acid Nonasodium Salt is a fundamental constituent in the pharmaceutical formulation playing a pivotal role in studying diverse pathological conditions particularly targeting inflammation control, cancer and bacterial infections. Synonyms: Nona-Guluronic Acid Sodium Salt. Grades: ≥93% by GPC. Molecular formula: C54H65O55Na9. Mole weight: 1800.96.
Lucidenic acid C
Lucidenic acid C, an organic compound derived from the fungus Ganoderma lucidum, exhibits multifaceted pharmacological actions such as antioxidant, anti-inflammatory, immunomodulatory, and anticancer properties. Novel studies have elucidated that this naturally occurring triterpene exhibits profound inhibition of malignancy development and metastasis in cancer cells. The promising therapeutic potential of lucidenic acid C extends beyond oncology, offering a plethora of therapeutic applications in diverse pathological conditions. Synonyms: Lucidenic acid C; (3beta,5alpha,7beta,12beta)-3,7,12-Trihydroxy-4,4,14-trimethyl-11,15-dioxo-chol-8-en-24-oic acid. Grades: >98%. CAS No. 95311-96-9. Molecular formula: C27H40O7. Mole weight: 476.6023.
Mant-cGMP
Mant-cGMP is a crucial tool extensively utilized in biomedical research. It serves as a fluorescent probe for studying guanine nucleotide exchange reactions and has a wide range of applications. Mant-cGMP enables the investigation of cyclic guanosine monophosphate (cGMP)-dependent physiological and pathological processes, including drug discovery and the treatment of cardiovascular diseases and pulmonary hypertension. Synonyms: 2'-O-(N-Methyl-anthraniloyl)-guanosine-3',5'-cyclic monophosphate, Sodium salt. Grades: ≥ 98 % by HPLC. CAS No. 83707-15-7. Molecular formula: C18H19N6O8P (free acid). Mole weight: 478.35 (free acid).
N1,N2-Dimethyl-2'-O-methylguanosine
N1,N2-Dimethyl-2'-O-methylguanosine, a pivotal component in biomedicine, elucidates its paramountcy in diverse pathological conditions, particularly within the domain of antiviral investigation. This compound manifests noteworthy antiviral efficacy against distinct viral variants, thereby captivating interest in medicinal exploration for mitigating viral afflictions. Grades: ≥95%. CAS No. 2305416-05-9. Molecular formula: C13H19N5O5. Mole weight: 325.32.
N4,N4,2'-O-Trimethylcytidine
N4,N4,2'-O-Trimethylcytidine is a remarkable and highly efficacious compound widely employed in the research of assorted pathological conditions including HIV, hepatitis C and influenza. Synonyms: Cytidine, N4,N4-dimethyl-2'-O-methyl-; N(4),N(4),O(2')-Trimethylcytidine; N,N,2'-O-Trimethylcytidine; 1-((2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-4-(dimethylamino)pyrimidin-2(1H)-one; N,N-Dimethyl-2'-O-methylcytidine. Grades: ≥95% by HPLC. CAS No. 34218-81-0. Molecular formula: C12H19N3O5. Mole weight: 285.30.
NAB 2
NAB 2 can protect against α-synuclein toxicity. It can reverse the α-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons and promote E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport. Synonyms: alphaSYN-IN-NAB2; alphaSYN IN NAB2; alphaSYNINNAB2; alphaSYN inhibitor NAB2; alphaSYN inhibitor-NAB2; NAB2; α-Synuclein inhibitor NAB2; αSyn-reversor-NAB2; Rsp5/Nedd4 actovator NAB2; NAB2; NAB 2; NAB-2; N-[(2-Chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide. Grades: ≥98% by HPLC. CAS No. 1504588-00-4. Molecular formula: C23H20ClN3O. Mole weight: 389.88.
N-Cyclopentyl-2'-C-methyl-adenosine
N-Cyclopentyl-2'-C-methyl-adenosine (CPMA) is a highly efficacious and specifically targeted agonist of adenosine A2A receptors, used for studying diverse pathological conditions including Parkinson's disease, cancer and inflammation. Synonyms: (2R,3R,4R,5R)-2-(6-(Cyclopentylamino)-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol; Adenosine, N-cyclopentyl-2'-C-methyl-; N-Cyclopentyl-2'-methyladenosine; 9-(2'-C-methyl-beta-D-ribofuranosyl)-6-(cyclopentylamino)purine; N6-Cyclopentyl-2'-C-methyl-adenosine. Grades: ≥97% by HPLC. CAS No. 205171-06-8. Molecular formula: C16H23N5O4. Mole weight: 349.38.
n-Dodecyl-β-D-Melibioside
n-Dodecyl-β-D-Melibioside is a compound utilized for studying a myriad of pathological conditions encompassing malignant neoplasms, inflammatory ailments and cerebral degenerative maladies. This biomedical substance possesses the capability to precisely interact with selective receptor entities or proteinaceous molecules. Synonyms: Lauryl Melibioside; Dodecyl 6-O-α-D-Galactopyranosyl-D-Glucopyranoside; β-DDMB. Grades: 98%. CAS No. 129932-38-3. Molecular formula: C24H46O11. Mole weight: 510.6.
N-Methyl-D-tryptophan
N-Methyl-D-tryptophan is a natural compound widely employed in pharmaceutical sector. Presently, this chemical constituent, predominantly present in diverse medicinal formulations exhibiting remarkable efficacy in studying numerous pathological conditions. Synonyms: n-methyl-d-tryptophan. Grades: >95% by HPLC. CAS No. 862504-05-0. Molecular formula: C12H14N2O2. Mole weight: 218.25.
OB-1
OB-1 is a stomatin-like protein-3 (STOML3) oligomerization inhibitor. It reverses pathological mechanical hypersensitivity in vivo, and reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo. Synonyms: Ethyl 5-(1-methyl-4-nitro-1H-imidazol-5-yloxy)-2-phenylbenzofuran-3-carboxylate. Grades: ≥98% by HPLC. CAS No. 300803-69-4. Molecular formula: C21H17N3O6. Mole weight: 407.38.
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