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| Product | Description | |
|---|---|---|
| 11alpha-Hydroxyprogesterone | 11alpha-Hydroxyprogesterone is the analogue of 11beta-Hydroxyprogesterone (HY-N2337), and can be used as an experimental control. 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase ; also activates human mineralocorticoid receptor in COS-7 cells with an ED 50 of 10 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 80-75-1. Pack Sizes: 25 mg; 50 mg. Product ID: HY-W011243. |  |
| 1,2,3,4-Tetra-O-pivaloyl-6-O-(tert-butyldiphenylsilyl)-b-D-glucopyranose | 1,2,3,4-Tetra-O-pivaloyl-6-O-(tert-butyldiphenylsilyl)-b-D-glucopyranose - a unique and multi-faceted chemical intermediate, proficiently applied in the synthesis of glycosidase inhibitors and other biologically active compounds. Endowed with an intricate molecular construction, this compound's multifarious properties are developed through a sequence of converging chemical pathways, intimately linked to an array of biological mechanisms. Venture into the intricate world of chemical synthesis with this remarkable intermediate, and unlock a world of possibilities in biomedicine. Molecular formula: C42H62O10Si. Mole weight: 755.04. |  |
| (2, 2-Difluorocyclopropyl) methylamine | (2, 2-Difluorocyclopropyl) methylamine is a difluorinated-derivative of Cyclopropylmethylamine (C988695) and is used as a reagent in the synthesis of pyrrolidine derivatives as alternative pathway modulators for the treatment of ophthalmic and other diseases. (2, 2-Difluorocyclopropyl) methylamine is also used as the starting material in the synthesis of dihydrodiazepines as protein kinases inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 847926-81-2. Pack Sizes: 100mg, 1g. Molecular Formula: C4H7F2N, Molecular Weight: 107.1. US Biological Life Sciences. |  Worldwide |
| 2-?[[2-? (Dimethylamino) ?ethyl]?thio]?-acetic Acid | 2-?[[2-? (Dimethylamino) ?ethyl]?thio]?-acetic Acid functions as a co-drugs, and also acts as a reagent for the preparation of hydroxamate-based histone deacetylase inhibitors for enhancing activity of antifungal agents which inhibit a step in the ergosterol synthesis pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 933682-63-4. Pack Sizes: 1g, 10g. Molecular Formula: C6H13NO2S, Molecular Weight: 163.24. US Biological Life Sciences. | Worldwide |
| 2,3,4-Tri-O-benzyl-D-glucopyranose | 2,3,4-Tri-O-benzyl-D-glucopyranose, a saccharide derivative, finds utility as an intermediate in the synthesis of bioactive small molecules with promising therapeutic applications, such as glycosidase inhibitors and neoglycoconjugates. Its involvement in these synthetic pathways showcases its potential in the development of novel therapeutic agents. CAS No. 47727-93-5. Molecular formula: C27H30O6. Mole weight: 450.52. | |
| 2,4-Dichloro-5-ethylpyrimidine | 2,4-Dichloro-5-ethylpyrimidine is a reactant used for the synthesis of pyrimidine derivatives as inhibitors of dipeptidyl peptidase IV, TBK1/IKKε kinases, and as an inhibitor of a hedgehog signaling pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 34171-40-9. Pack Sizes: 10mg, 25mg. Molecular Formula: C6H6Cl2N2, Molecular Weight: 177.03. US Biological Life Sciences. | Worldwide |
| 2,6-Difluorobenzoyl Chloride | 2,6-Difluorobenzoyl Chloride is used in the synthesis of a series of novel 2-aryl substituted 4H-3,1-benzoxazin-4-ones which are used as specific inhibitors of the Tissue Factor (TF)/Factor VIIa (FVIIa)-induced pathway of coagulation. Group: Biochemicals. Grades: Highly Purified. CAS No. 18063-02-0. Pack Sizes: 50g, 100g. Molecular Formula: C7H3ClF2O, Molecular Weight: 176.55. US Biological Life Sciences. | Worldwide |
| 2-?Chloro-?(N-?2,?6-?diethyl phenyl)?acetamide | 2-?Chloro-?(N-?2,?6-?diethyl phenyl)?acetamide is a reagent used in the synthesis of novel inhibitors of signal transducer and activator of the transcription (STAT3) signalling pathway which is used in the treatment of cancers. Group: Biochemicals. Grades: Highly Purified. CAS No. 6967-29-9. Pack Sizes: 250mg, 500mg. Molecular Formula: C12H16ClNO, Molecular Weight: 225.71. US Biological Life Sciences. | Worldwide |
| (2R)-2-Deoxy-2-fluoro-2-methyl-α-D-erythro-pentofuranose 3,5-Dibenzoate | (2R)-2-Deoxy-2-fluoro-2-methyl-α-D-erythro-pentofuranose 3,5-Dibenzoate has been employed in a study to investigate potent inhibitors against CD38 NADase, an enzyme involved with the metabolism of nicotinamide and calcium signalling pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 1639301-16-8. Pack Sizes: 10mg, 100mg. Molecular Formula: C20H19FO6, Molecular Weight: 374.36. US Biological Life Sciences. | Worldwide |
| (2R)-2-Deoxy-2-fluoro-2-methyl- β-D-erythro-pentofuranose 3,5-Dibenzoate | (2R)-2-Deoxy-2-fluoro-2-methyl- β-D-erythro-pentofuranose 3,5-Dibenzoate has been employed in a study to investigate potent inhibitors against CD38 NADase, an enzyme involved with the metabolism of nicotinamide and calcium signalling pathway. It also has utility in the stereoselective synthesis of β-D-2'-Deoxy-2'-α-fluoro-2'- β-C-methyl-3',5'-cyclic phosphate nucleotide, a prodrug for treating hepatitis C virus (HCV) infection. Group: Biochemicals. Grades: Highly Purified. CAS No. 1199809-22-7. Pack Sizes: 50mg, 100mg. Molecular Formula: C20H19FO6, Molecular Weight: 374.36. US Biological Life Sciences. | Worldwide |
| (2R)-2-Deoxy-2-fluoro-2-methyl- β-D-erythro-pentofuranosyl Chloride 3,5-Dibenzoate | (2R)-2-Deoxy-2-fluoro-2-methyl- β-D-erythro-pentofuranosyl Chloride 3,5-Dibenzoate is a related compound of (2R)-2-Deoxy-2-fluoro-2-methyl- β-D-erythro-pentofuranose 3,5-Dibenzoate (D235550) and (2R)-2-Deoxy-2-fluoro-2-methyl-α-D-erythro-pentofuranose 3,5-Dibenzoate (D235555). These compounds can be used to investigate potent inhibitors against CD38 NADase, an enzyme involved with the metabolism of nicotinamide and calcium signalling pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 1500076-79-8. Pack Sizes: 5mg, 50mg. Molecular Formula: C20H18ClFO5, Molecular Weight: 392.81. US Biological Life Sciences. | Worldwide |
| 3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one | 3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one functions as CD40-TRAF6 inhibitors. Inhibition of CD40 signalling pathway seems a better way to ameliorate inflammatory diseases, like the inflammation in models of peritonitis and sepsis. Group: Biochemicals. Grades: Highly Purified. CAS No. 433249-94-6. Pack Sizes: 100mg, 50mg. Molecular Formula: C17H17NO, Molecular Weight: 251.32. US Biological Life Sciences. | Worldwide |
| 3,4-Dimethoxycinnamic Acid | 3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway. Anti-apoptotic effects. Group: Inhibitors. Alternative Names: Methylferulic acid. CAS No. 2316-26-9. Molecular formula: C11H12O4. Mole weight: 208.21. Appearance: Solid. Purity: 0.98. IUPACName: (E)-3-(3,4-Dimethoxyphenyl)prop-2-enoic acid. Canonical SMILES: COC1=C(C=C(C=C1)C=CC(=O)O)OC. Density: 1.0627 g/cm³. Catalog: ACM2316269. |  |
| 3-Aminobenzoic acid | 3-Aminobenzoic acid (3-ABA) is an orally active anti-inflammatory agent targeting the tight junction (TJ) regulatory pathways in intestinal epithelial cells. 3-Aminobenzoic acid improves intestinal inflammation by enhancing intestinal barrier integrity and reducing epithelial permeability. It can be used in studies related to improving gut health. Additionally, 3-Aminobenzoic acid analogs can act as γ-aminobutyric acid transaminase ( GABA-AT ) inhibitors, exhibiting anticonvulsant effects [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: m-Aminobenzoic acid; 3ABA. CAS No. 99-05-8. Pack Sizes: 10 mM * 1 mL; 100 g. Product ID: HY-I0746. | |
| 3-Azabicyclo[3. 3. 0]octane Hydrochloride | 3-Azabicyclo[3. 3. 0]octane Hydrochloride is a reactant in the preparation of substituted pyrimidines derivatives as novel hedgehog signaling pathway inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 112626-50-3. Pack Sizes: 1g, 10g. Molecular Formula: C7H14ClN, Molecular Weight: 147.65. US Biological Life Sciences. | Worldwide |
| 3-?Benzylaniline | 3-?Benzylaniline is used to synthesize pyrrolidine carboxamides as inhibitors of Mycobacterial enoyl acyl carrier protein reductase. It is used to prepare nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 61424-26-8. Pack Sizes: 1g, 5g. Molecular Formula: C13H13N, Molecular Weight: 183.25. US Biological Life Sciences. | Worldwide |
| 3-Deoxysappanchalcone | 3-Deoxysappanchalcone is a naturally-occurring chalcone compound isolated from Caesalpinia sappan L. (Leguminosae), which possesses anti-allergic, antiviral, anti-inflammatory and antioxidant activities. 3-Deoxysappanchalcone exerts anti-inflammatory activity via induce heme oxygenase-1 (HO-1) expression by activating the AKT/mTOR pathway in murine macrophages. 3-Deoxysappanchalcone also exhibits anti-influenza virus activity (H3N2, IC50 = 1.06 μM). Group: Inhibitors. CAS No. 112408-67-0. Molecular formula: C16H14O4. Mole weight: 270.28. Appearance: Solid. Purity: 0.9926. Canonical SMILES: O=C (C1=CC=C (O)C=C1OC)/C=C/C2=CC=C (O)C=C2. [ (E)]. Catalog: ACM112408670. | |
| (3S,4R)-3-(Hydroxymethyl)-3,4-pyrrolidinediol | (3S,4R)-3-(Hydroxymethyl)-3,4-pyrrolidinediol is a salient intermediate integral to bioactive compound construction. In particular, the production of HIV protease inhibitors can leverage this compound, thereby forging a pathway toward effective HIV infection treatment. Synonyms: isoDAB; (3S,4R)-3-(hydroxymethyl)-3,4-Pyrrolidinediol. CAS No. 1241760-33-7. Molecular formula: C5H11NO3. Mole weight: 133.15. | |
| 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline | 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline (Compound 11 and 15) is a building block and synthetic intermediate, which can be used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone deacetylase (HDAC) inhibitors, and anticancer agents. 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline can also be used to synthesize EGFR inhibitors, including Erlotinib (HY-50896), with antiproliferative activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 183322-18-1. Pack Sizes: 50 mg; 100 mg; 500 mg. Product ID: HY-W007977. | |
| 4'-Hydroxywogonin | 4'-Hydroxywogonin (8-Methoxyapigenin), a flavonoid, could be isolated from a variety of plants including Scutellaria barbata and Verbena littoralis. 4'-Hydroxywogonin has anti-inflammatory activity via TAK1/IKK/NF-κB, MAPKs and PI3/AKT signaling pathways. 4'-Hydroxywogonin inhibits angiogenesis by disrupting PI3K/AKT signaling. 4'-Hydroxywogonin inhibits cell proliferation and induces apoptosis. Group: Inhibitors. CAS No. 57096-02-3. Molecular formula: C16H12O6. Mole weight: 300.3. Appearance: Yellow powder. Purity: 0.98. IUPACName: 5,7-dihydroxy-2-(4-hydroxyphenyl)-8-methoxychromen-4-one. Canonical SMILES: COC1=C (C=C (C2=C1OC (=CC2=O)C3=CC=C (C=C3)O)O)O. Catalog: ACM57096023. | |
| 5-Bromoindole | 5-Bromoindole is a chemical intermediate that can be used for the synthesis of GSK-3 inhibitors and anti-cancer agents [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 10075-50-0. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g; 25 g. Product ID: HY-30236. | |
| 5-Bromopentanoic acid | 5-Bromopentanoic acid can be used for the synthesis of inhibitors for aminoglycoside resistant bacteria [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2067-33-6. Pack Sizes: 1 mg. Product ID: HY-W016456. | |
| 5-Methoxyindole-3-acetonitrile-d2 | 5-Methoxyindole-3-acetonitrile-d2 is a labelled analogue of 5-Methoxyindole-3-acetonitrile (M262818), which is a versatile reactant used in the preparation of indole-N-acetic acid derivatives as aldose reductase inhibitors for diabetic complications treatment. It is also used in the synthesis of carboline analogs as potent MAPKAP-K2 inhibitors. 5-Methoxyindole-3-acetonitrile-d2 is also an intermediate in synthesizing Melatonin-d4 (M215002), a hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation / metastasis of breast cancer cells by inhibiting estrogen receptor action. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C11H8D2N2O. US Biological Life Sciences. | Worldwide |
| 6R-FR054 | 6R-FR054 is a 6R-isomer of FR054. FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect. FR054 induces in different breast cancer cells a dramatic decrease in cell proliferation and survival. In particular, in a model of Triple Negative Breast Cancer (TNBC) cells, MDA-MB-231, these effects are correlated to FR054-dependent reduction of both N- and O-glycosylation level that cause also a strong reduction of cancer cell adhesion and migration. Note: The correct structure for FR054 is CAS#35954-65-5 which is the 6S-isomer. Some vendors are selling wrong structure for FAR054 (the incorrect structure has CAS#10378-06-0, which is the 6R-isomer). Group: Inhibitors. Alternative Names: 6R-FR054; 6R-FR-054; 6R-FR 054. CAS No. 10378-06-0. Molecular formula: C14H19NO8. Mole weight: 329.31. Appearance: Semi-solid or waxy solid or viscous solid. Purity: >98%. IUPACName: 5H-Pyrano[3,2-d]oxazole-6,7-diol, 5-[(acetyloxy)methyl]-3a,6,7,7a-tetrahydro-2-methyl-, diacetate (ester), (3aR,5R,6R,7R,7aR)-. Canonical SMILES: CC1=N[C@@] ([C@@H] (OC (C)=O)[C@@H] (OC (C)=O)[C@@H] (COC (C)=O)O2) ([H])[C@@]2 ([H])O1. Catalog: ACM10378060. | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-Rho11 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-Rho11 is an indispensable fluorescent probe of significant value in biomedical research for the efficient imaging of cGMP signaling pathways. Its comprehensive functionality further extends to aiding in the effective visualization of cGMP activity across diverse cell types, including neurons and smooth muscle cells. Numerous studies have showcased the presence of cGMP signaling in blood pressure regulation, platelet aggregation, and smooth muscle relaxation, under the influence of nitric oxide. Moreover, cGMP levels can be efficiently monitored by this probe, in sync with the effects of phosphodiesterase inhibitors. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO Rho11, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C51H63N10O10P (free acid). Mole weight: 1006.44 (free acid). | |
| abieta-7,13-diene hydroxylase | A heme-thiolate protein (P-450). This enzyme catalyses a step in the pathway of abietic acid biosynthesis. The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine). The enzyme is localized in the microsomal fraction and requires both oxygen and NADPH. Inhibition by carbon monoxide and several substituted N-heterocyclic inhibitors suggests that the enzyme is a cytochrome P-450-dependent monooxygenase. Activity is induced by wounding of the plant tissue. Group: Enzymes. Synonyms: abietadiene hydroxylase (ambiguous). Enzyme Commission Number: EC 1.14.13.108. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0707; abieta-7,13-diene hydroxylase; EC 1.14.13.108; abietadiene hydroxylase (ambiguous). Cat No: EXWM-0707. |  |
| Adavivint | Adavivint, also known as SM04690 and LORECIVIVINT, is a small-molecule inhibitor of the Wnt pathway which is being investigated as a potential disease modifying agent for the treatment of osteoarthritis of the knee. Group: Inhibitors. Alternative Names: Adavivint; SM-04690; SM04690; SM 04690. CAS No. 1467093-03-3. Molecular formula: C29H24FN7O. Mole weight: 505.56. Appearance: Solid powder. Purity: >98%. IUPACName: N-(5-(3-(7-(3-Fluorophenyl)-3H-imidazo(4,5-C)pyridin-2-yl)-1H-indazol-5- yl)-pyridin-3-yl)-3-methylbutanamide. Canonical SMILES: CC (C)CC (=O)Nc1cncc (c1)c2ccc3[nH]nc (c4nc5c (cncc5[nH]4)c6cccc (F)c6)c3c2. Catalog: ACM1467093033. | |
| Adenylyl-3'-5'-cytidine | Adenylyl-3'-5'-cytidine is a highly effective and specialized adenylyl cyclase activator, holding applications in biomedical research for investigating the cyclic adenosine monophosphate (cAMP) signaling pathways. Uses: Enzyme inhibitors. Synonyms: Adenylyl-3'-5'-D-cytidine. Grades: 98%. CAS No. 2382-66-3. Molecular formula: C19H25N8O11P. Mole weight: 572.42. | |
| Aloxistatin (E-64d) | Aloxistatin (E-64d), is a selective cysteine protease inhibitor or calpain and autophagy inhibitor. E-64d prevents in vitro cerulein- induced trypsinogen activation. E-64d can enter the intact cell and inhibit calpain. E-64d has been shown safe for the treatment of Alzheimer's disease in human. E-64d is potentially useful in the treatment of developmental seizure-induced brain damage both by regulating abnormal zinc signal transduction and through the modulation of altered lipid metabolism via ApoE/clusterin pathway in hippocampus. Group: Inhibitors. Alternative Names: E-64d; E 64d; E64d; E64-d; E64-d; E64 d; ethyl ester Loxistatin; NSC 694281; NSC694281; NSC-694281; EST; EP-453; EP453; EP 453; Aloxistatin. CAS No. 88321-09-9. Molecular formula: C17H30N2O5. Mole weight: 342.44. Appearance: Solid powder. Purity: >98%. IUPACName: ethyl (2S,3S)-3-(((S)-1-(isopentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxylate. Canonical SMILES: CCOC ([C@@H]1[C@@H] (C (N[C@H] (C (NCCC (C)C)=O)CC (C)C)=O)O1)=O. Catalog: ACM88321099. | |
| AMXI-5001 | AMXI-5001 is a potent, orally active, and dual parp1/2 and microtubule polymerization inhibitor. MXI-5001 exhibits selective antitumor cytotoxicity across a wide variety of human cancer cells with much lower IC 50 s than existing clinical PARP1/2 inhibitors. AMXI-5001 induces complete regression of established tumors, including exceedingly large tumors [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2170491-77-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145734. | |
| Angelicin | Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, structurally related to psoralens, is reported to have anti-cancer, antiviral, anti-inflammatory activity.IC50 value: 49.56 μM (cellular cytotoxicity); 5.39 μg/ml (28.95 μM) (against MHV-68)Target:In vitro: In human SH-SY5Y neuroblastoma cells, angelicin increased cellular cytotoxicity in a dose- and time-dependent manner with IC50 of 49.56 μM at 48 h of incubation. Angelicin dose-dependently downregulated the expression of anti-apoptotic proteins including Bcl-2, Bcl-xL, and Mcl-1; Angelicin-induced apoptosis is mediated primarily through the intrinsic caspase-mediated pathway. Angelicin efficiently inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lytic replication of human gammaherpresviruses in both EBV- and KSHV-infected cells. Angelicin was potentially advantageous to prevent inflammatory diseases by inhibiting NF-κB and MAPK pathways.In vivo: Group: Inhibitors. CAS No. 523-50-2. Molecular formula: C11H6O3. Mole weight: 186.16. Appearance: Solid. Purity: 0.9986. Canonical SMILES: O=C1C=CC2=CC=C(OC=C3)C3=C2O1. Catalog: ACM523502. | |
| Arg-Gly-Asp-Ser | Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. It is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. It inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor. It promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro. It also blocks the attachment of certain pathogens to cells. Uses: Platelet aggregation inhibitors. Synonyms: Arg Gly Asp Ser; RGDS peptide; Fibronectin Inhibitor. Grades: >98%. CAS No. 91037-65-9. Molecular formula: C15H27N7O8. Mole weight: 433.42. | |
| Aristolactam I | Aristololactam I (AL-I), is the main metabolite of aristolochic acid I (AA-I), participates in the processes that lead to renal damage.Aristololactam I (AL-I) directly injures renal proximal tubule cells, the cytotoxic potency of AL-I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase-3-dependent pathway. Group: Inhibitors. Alternative Names: 8-Methoxy-6-aminophenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid 5,6-lactam. CAS No. 13395-02-3. Molecular formula: C17H11NO4. Mole weight: 293.27. Appearance: Powder. Purity: 0.98. IUPACName: 14-Methoxy-3, 5-dioxa-10-azapentacyclo[9.7.1.02, 6.08, 19.013, 18]nonadeca-1(18), 2(6), 7, 11(19), 12, 14, 16-heptaen-9-one. Canonical SMILES: COC1=CC=CC2=C3C4=C (C=C21)NC (=O)C4=CC5=C3OCO5. Density: 1.49 g/ml. Catalog: ACM13395023. | |
| Artemisinin | Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects. Group: Inhibitors. Alternative Names: Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10(3H)-one. CAS No. 63968-64-9. Molecular formula: C15H22O5. Mole weight: 282.33. Appearance: White powder. Purity: 0.98. IUPACName: (1R, 4S, 5R, 8S, 9R, 12S, 13R)-1, 5, 9-trimethyl-11, 14, 15, 16-tetraoxatetracyclo[10.3.1.04, 13.08, 13]hexadecan-10-one. Canonical SMILES: C[C@@H]1CC[C@H]2[C@H] (C (=O)O[C@H]3[C@@]24[C@H]1CC[C@] (O3) (OO4)C)C. Density: 1.098 g/ml. Catalog: ACM63968649. | |
| Asperosaponin Vi | Asperosaponin VI, A saponin component from Dipsacus asper, induces osteoblast differentiation through BMP-2/p38 and ERK1/2 pathway. Asperosaponin ? inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB. Group: Inhibitors. CAS No. 39524-08-8. Molecular formula: C47H76O18. Mole weight: 929.1. Appearance: White powder. Purity: 0.98. IUPACName: [(3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl] (6aS,9R)-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-10-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate. Canonical SMILES: CC1 (CCC2 (CCC3 (C (=CCC4C3 (CCC5C4 (CCC (C5 (C)CO)OC6C (C (C (CO6)O)O)O)C)C)C2C1)C)C (=O)OC7C (C (C (C (O7)COC8C (C (C (C (O8)CO)O)O)O)O)O)O)C. Catalog: ACM39524088. | |
| ASTX-029 | ASTX029 is a highly potent and selective dual-mechanism ERK inhibitor. ASTX029 inhibits both ERK catalytic activity and the phosphorylation of ERK itself by MEK, despite not directly inhibiting MEK activity. ASTX029 preferentially inhibited the proliferation of MAPK-activated cell lines, including those with BRAF or RAS mutations. ASTX029 also demonstrated activity in both in vitro and in vivo models of acquired resistance to MAPK pathway inhibitors. Group: Inhibitors. Alternative Names: ASTX-029; ASTX029; ASTX 029. CAS No. 2095719-92-7. Molecular formula: C29H31ClFN5O5. Mole weight: 584.05. Appearance: Solid powder. Purity: >98%. IUPACName: (R)-2-(6-(5-chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1-oxoisoindolin-2-yl)-N-((S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl)propanamide. Canonical SMILES: ClC (C (C1=CC=C2C (C (N ([C@H] (C) C (N[C@H] (CO) C3=CC (OC) =CC (F) =C3) =O) C2) =O) =C1) =N4) =CN=C4NC5CCOCC5. Catalog: ACM2095719927. | |
| Aurintricarboxylic Acid | Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively. Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase. Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis. Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway. Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC50 of 0.6 μM. Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC50 of 0.47 μM. Group: Inhibitors. Alternative Names: Ata. CAS No. 4431-00-9. Molecular formula: C22H14O9. Mole weight: 422.34. Appearance: Powder. Purity: 0.85. Canonical SMILES: C1=CC (=C (C=C1C (=C2C=CC (=O)C (=C2)C (=O)O)C3=CC (=C (C=C3)O)C (=O)O)C (=O)O)O. Catalog: ACM4431009. | |
| AZD5153 | AZD5153 (Compound 13) is a trivalent triazolpyrazine bromide domain (BRD), bromodomain and extraterminal (BET) inhibitor. AZD5153 has down-regulated c-Myc gene and tumor growth inhibition activity. AZD5153 can be used in the study of BET small molecule inhibitors [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1869912-39-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-100653. | |
| AZD8186 | AZD8186 is and inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity. Upon administration, PI3Kbeta inhibitor AZD8186 selectively inhibits the activity of PI3Kbeta in the PI3K/Akt/mTOR signaling pathway, which may result in a decrease of tumor cell proliferation. It also induces cell death in PI3K-expressing cancer cells. By specifically targeting class I PI3K beta, this agent may be more efficacious and less toxic than pan PI3K inhibitors. PI3K-mediated signaling is often dysregulated in cancer cells and contributes to increased tumor cell growth, survival, and tumor resistance to a variety of antineoplastic agents. AZD8186 is currently under Phase I clinical trials. Group: Inhibitors. Alternative Names: AZD8186; AZD 8186; AZD-8186. CAS No. 1627494-13-6. Molecular formula: C24H25F2N3O4. Mole weight: 457.4. Appearance: Solid powder. Purity: >98%. IUPACName: (R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide. Canonical SMILES: O=C (N (C)C)C1=CC ([C@@H] (C)NC2=CC (F)=CC (F)=C2)=C3C (C (C=C (O3)N4CCOCC4)=O)=C1. Catalog: ACM1627494136. | |
| BAI1 hydrochloride | BAI1 hydrochloride is a selective apoptosis factor BAX allosteric inhibitors. BAI1 hydrochloride binds BAX and allosterically inhibits its activation. BAI1 hydrochloride has the potential to be used in the study of BAX dependent cell death-mediated diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 329349-20-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-110031. | |
| Bakkenolide A | Bakkenolide A is a natural product extracted from Petasites tricholobus. Bakkenolide A inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related signaling pathways. Group: Inhibitors. CAS No. 19906-72-0. Molecular formula: C15H22O2. Mole weight: 234.33. Canonical SMILES: O=C ([C@@]12C[C@@]3 ([H])CCC[C@H] (C)[C@@]3 (C)C2)OCC1=C. Catalog: ACM19906720. | |
| Bardoxolone methyl | Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) is a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities, acting as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway. Group: Inhibitors. Alternative Names: Bardoxolone methyl;CDDO-Me;CDDO methyl ester;218600-53-4;RTA 402;NSC 713200;NSC713200;RTA-402;RTA402;UNII-CEG1Q6OGU1;CEG1Q6OGU1;NSC-713200;bardoxolone-methyl;(4aS, 6aR, 6bS, 8aR, 12aS, 14aR, 14bS)-methyl 11-cyano-2, 2, 6a, 6b, 9, 9, 12a-heptamethyl-10, 14-dioxo-1, 2, 3, 4, 4a, 5, 6, 6a, 6b, 7, 8, 8a, 9, 10, 12a, 14, 14a, 14b-octadecahydropicene-4a-carboxylate;CDDO-Methyl ester;methyl 2-cyano-3,12-. CAS No. 218600-53-4. Molecular formula: C32H43NO4. Mole weight: 505.7g/mol. Appearance: Solid. Purity: 0.9972. IUPACName: methyl (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylate. Canonical SMILES: CC1 (CCC2 (CCC3 (C (C2C1)C (=O)C=C4C3 (CCC5C4 (C=C (C (=O)C5 (C)C)C#N)C)C)C)C (=O)OC)C. ECNumber: 606-850-4. Catalog: ACM218600534. | |
| BI-882370 | BI-882370 is a highly potent, selective, orally active RAF inhibitor with IC50 of 0.4, 0.8 and 0.6 nM for BRAF V600E, BRAF WT and CRAF, respectively. BI-882370 is a potent and selective RAF inhibitor uniquely binding to the DFG-out conformation, whereas marketed BRAF inhibitors occupy the DFG-in conformation. BI-882370 inhibits proliferation of human BRAF-mutant melanoma cells with 100× higher potency (1-10 nmol/L) than vemurafenib. BI-882370 may provide an improved therapeutic window, enabling more pronounced and longer-lasting pathway suppression and thus resulting in improved efficacy. Synonyms: BI882370; BI 882370. Grades: ≥95%. CAS No. 1392429-79-6. Molecular formula: C28H33F2N7O2S. Mole weight: 569.7. | |
| Bilobalide | Bilobalide, a sesquiterpene trilactone constituent of Ginkgo biloba, inhibits the NMDA-induced efflux of choline with an IC50 value of 2.3 μM. Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells. Exerts protective and trophic effects on neurons. Group: Inhibitors. Alternative Names: (-)-Bilobalide. CAS No. 33570-04-6. Molecular formula: C15H18O8. Mole weight: 326.3. Purity: 0.98. Canonical SMILES: CC (C) (C)[C@@]1 (C[C@H]2[C@@]3 ([C@]14[C@H] (C (=O)O[C@H]4OC3=O)O)CC (=O)O2)O. Catalog: ACM33570046. | |
| Bimiralisib free base | Bimiralisib, also known as PQR309, is an orally bioavailable pan inhibitor of phosphoinositide-3-kinases (PI3K) and inhibitor of the mammalian target of rapamycin (mTOR), with potential antineoplastic activity. PI3K/mTOR kinase inhibitor PQR309 inhibits the PI3K kinase isoforms alpha, beta, gamma and delta and, to a lesser extent, mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to both chemotherapy and radiotherapy. Group: Inhibitors. Alternative Names: PQR309; PQR-309; PQR309; Bimiralisib free base. CAS No. 1225037-39-7. Molecular formula: C17H20F3N7O2. Mole weight: 411.39. Appearance: Solid powder. Purity: >98%. IUPACName: 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine. Canonical SMILES: NC1=NC=C (C2=NC (N3CCOCC3)=NC (N4CCOCC4)=N2)C (C (F) (F)F)=C1. Catalog: ACM1225037397. | |
| B-Raf inhibitor 1 dihydrochloride | B-Raf inhibitor 1 is an inhibitor of B-Raf kinase with IC50 values of 0.31μM and 0.72μM for cell proliferation, respectively in A375 and HCT116. B-Raf is important in signal transduction and some mutant B-Raf occurs in cancer cells. The most common mutation of these is V600E, which makes B-Raf kinase constitutively active. B-Raf inhibitor 1 belongs to the type IIA inhibitors and binds to the DFG-out ATP-binding site of B-Raf. The selectivity of B-Raf inhibitor 1 is less than of other type inhibitors. Besides mutant B-Raf, it can also inhibit wild type B-Raf and other tyrosine kinase. In cells with wild type B-Raf, B-Raf inhibitor 1 can activate the RAF-MEK-ERK signaling pathway via Raf dimerization. The preclinical toxicity test shows B-Raf inhibitor 1 can induce hyperplasia in a mouse model. Synonyms: 1,5-Isoquinolinediamine, N1-(4-chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, hydrochloride (1:2). Grades: >98%. CAS No. 1191385-19-9. Molecular formula: C26H21Cl3N8. Mole weight: 551.86. | |
| Broussonin E | Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis. Group: Inhibitors. CAS No. 90902-21-9. Molecular formula: C17H20O4. Mole weight: 288.3. Appearance: Powder. Purity: 0.98. IUPACName: 5-[3-(2-hydroxy-4-methoxyphenyl)propyl]-2-methoxyphenol. Canonical SMILES: COC1=CC (=C (C=C1)CCCC2=CC (=C (C=C2)OC)O)O. Catalog: ACM90902219. | |
| CC-115 | CC-115 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR), with potential antineoplastic activity. CC-115 binds to and inhibits the activity of DNA-PK and both raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2), which may lead to a reduction in cellular proliferation of cancer cells expressing DNA-PK and TOR. DNA-PK, a serine/threonine kinase and a member of the PI3K-related kinase subfamily of protein kinases, is activated upon DNA damage and plays a key role in repairing double-stranded DNA breaks via the DNA nonhomologous end joining (NHEJ) pathway. Group: Inhibitors. Alternative Names: CC115 ; CC-115; CC 115. CAS No. 1228013-15-7. Molecular formula: C16H16N8O. Mole weight: 336.14. Appearance: Red solid powder. Purity: >98%. IUPACName: 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one. Canonical SMILES: O=C1CNC2=NC=C (C3=CC=C (C4=NC=NN4)N=C3C)N=C2N1CC. Catalog: ACM1228013157. | |
| Chelidamic acid | Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with noble metal ions. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a K i of 33 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 138-60-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-W016349. | |
| Chidamide | Chidamide, also known as CS055 and HBI-8000, is an orally bioavailable benzamide type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10, with potential antineoplastic activity. Chidamide selectively binds to and inhibits HDAC leading to an increase of acetylation levels of histone protein H3. This agent also inhibits the expression of signaling kinases in the PI3K/Akt and MAPK/Ras signaling pathways and may result in cell cycle arrest and the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, a class of enzymes that deacetylate chromatin histone proteins, are upregulated in many tumor types and play key roles in gene expression. Compared to some other benzamide type HDAC inhibitors, chidamide is more stable, more resistant to degradation and has a longer half-life. Synonyms: CS055; CS-055; CS 055; HBI-8000; HBI 8000; HBI8000; N-(2-amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-benzamide. CAS No. 743420-02-2. Molecular formula: C22H19FN4O2. Mole weight: 390.418. | |
| Chloranthalactone B | Chloranthalactone B, a lindenane-type sesquiterpenoid, is a nature product that could be isolated from Chinese medicinal herb Sarcandra glabra. Chloranthalactone B inhibits the production of inflammatory mediators by inhibiting the AP-1 and p38 MAPK pathways. Group: Inhibitors. CAS No. 66395-03-7. Molecular formula: C15H16O3. Mole weight: 244.29. Appearance: Powder. Purity: 0.98. Canonical SMILES: CC1=C2CC3C (=C)C4CC4C3 (C5C2 (O5)OC1=O)C. Catalog: ACM66395037. | |
| Chrysomycin a | Chrysomycin A (Chr-A), an antibiotic, can be obtained from Streptomyces. Chrysomycin A exhibits antitumor and anti-tuberculous and MRSA activities. As for glioblastoma, Chrysomycin A inhibits the proliferation, migration, and invasion of cancer cells through the Akt/GSK-3β/β-catenin signaling pathway. Group: Inhibitors. Alternative Names: Albacarcin V, MLS002701849, NSC354844, 1,5-anhydro-6-deoxy-1-(8-ethenyl-1-hydroxy-10,12-dimethoxy-6-oxo-6h-dibenzo[c,h]chromen-4-yl)-3-c-methylhexitol, 82196-88-1, VIRENOMYCIN V, AC1Q6MMD, AC1L3VB3, KST-1B9536, AR-1B8017, NSC613946, NSC 354844, NSC-354844, NSC-613946, NCI60_003193, SMR001565441, 4-(6-Deoxy-3-C-methyl-.beta.-gulopyranosyl)-8-vinyl-1-hydroxy-10,12-dimethoxy-6H-benzo[d]naphtho[1,2-b]pyran-6-one (chrysomycin A), 6H-Benzo(d)naphtho(1,2-b)pyran-6-one, 4-(6-deoxy-3-C-methyl-beta-L-gulopyranosyl)-8-ethenyl-1-hydroxy-10,12-dimethoxy-, 6H-Benzo[d]naphtho[1, 4-(6-deoxy-3-C-methyl-.beta.-D-gulopyranosyl)-8-ethenyl-1-hydroxy-10,12-dimethoxy-, 6H-Benzo[d]naphtho[1,4-(6-deoxy-3-C-methyl-.beta.-D-gulopyranosyl-8-ethenyl-1-hydroxy-10,12-dimethoxy-. CAS No. 82196-88-1. Molecular formula: C28H28O9. Mole weight: 508.52. Purity: 0.96. IUPACName: 8-ethenyl-1-hydroxy-10,12-dimethoxy-4-(3,4,5-trihydroxy-4,6-dimethyloxan-2-yl)naphtho[1,2-c]isochromen-6-one. Canonical SMILES: CC1C (C (C (C (O1)C2=C3C (=C (C=C2)O)C (=CC4=C3OC (=O)C5=CC (=CC (=C54)OC)C=C)OC)O) (C)O)O. Density: 1.405g/cm³. C | |
| Cimiside E | Cimiside E (25-Anhydrocimigenol xyloside) is a triterpene xyloside, Cimiside E possesses apoptotic action on gastric cancer cells, with an IC50 value of 14.58 μM. Cimiside E induces cell cycle arrest at G2/M phase, and mediates apoptosis through the induction of the caspase cascade for both the extrinsic and intrinsic pathways. Group: Inhibitors. CAS No. 154822-57-8. Molecular formula: C35H54O8. Mole weight: 602.8. Appearance: Powder. Purity: 0.98. Canonical SMILES: CC1CC2C (OC3 (C1C4 (CCC56CC57CCC (C (C7CCC6C4 (C3O)C) (C)C)OC8C (C (C (CO8)O)O)O)C)O2)C (=C)C. Catalog: ACM154822578. | |
| Clarithromycin | Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM. Clarithromycin significantly inhibits the HERG potassium current.Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K. Group: Inhibitors. Alternative Names: Erythromycin, 6-O-methyl-. CAS No. 81103-11-9. Molecular formula: C38H69NO13. Mole weight: 747.95. Purity: 0.999. Catalog: ACM81103119-1. | |
| Coelonin | Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein. Group: Inhibitors. Alternative Names: 9,10-Dihydro-4-methoxy-2,7-phenanthrenediol. CAS No. 82344-82-9. Molecular formula: C15H14O3. Mole weight: 242.27. Appearance: Solid. Purity: 0.98. IUPACName: 4-methoxy-9,10-dihydrophenanthrene-2,7-diol. Canonical SMILES: COC1=CC(=CC2=C1C3=C(CC2)C=C(C=C3)O)O. Catalog: ACM82344829. | |
| CUDC-907 | CUDC-907 is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, CUDC-907 inhibits the activity of both PI3K class I isoforms and HDAC, thereby preventing the activation of the PI3K-AKT-mTOR signal transduction pathway that is often overactivated in many cancer cell types. This may prevent growth of PI3K and/or HDAC-expressing tumor cells. CUDC-907 shows an increased inhibition of tumor cell growth and induction of apoptosis when compared to inhibitors that target either PI3K or HDAC. Synonyms: CUDC907; CUDC 907; CUDC-907. CAS No. 1339928-25-4. Molecular formula: C23H24N8O4S. Mole weight: 508.557. | |
| Cudraflavone B | Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells. Group: Inhibitors. CAS No. 19275-49-1. Molecular formula: C25H24O6. Mole weight: 420.45. Appearance: Powder. Purity: 0.98. IUPACName: 8-(2,4-dihydroxyphenyl)-5-hydroxy-2,2-dimethyl-7-(3-methylbut-2-enyl)pyrano[3,2-g]chromen-6-one. Canonical SMILES: CC (=CCC1=C (OC2=CC3=C (C=CC (O3) (C)C)C (=C2C1=O)O)C4=C (C=C (C=C4)O)O)C. Catalog: ACM19275491. | |
| Danshensu | Danshensu, an active ingredient of Salvia miltiorrhiza, shows wide cardiovascular benefit by activating Nrf2 signaling pathway. Group: Inhibitors. Alternative Names: (R)-2-Hydroxy-3-(3,4-dihydroxyphenyl)propanoic acid. CAS No. 76822-21-4. Molecular formula: C9H10O5. Mole weight: 198.17. Appearance: Light beige solid. Purity: 0.98. IUPACName: (2R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid. Canonical SMILES: C1=CC(=C(C=C1C[C@H](C(=O)O)O)O)O. Density: 1.546 g/ml. Catalog: ACM76822214. | |
| Deoxynivalenol | Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Vomitoxin. CAS No. 51481-10-8. Pack Sizes: 1 mg. Product ID: HY-N6684. | |
| D-Saccharic acid 1,4-lactone hydrate | D-Saccharic acid 1,4-lactone hydrate is an orally active β-glucuronidase inhibitor ( IC 50 =48.4 μM). D-Saccharic acid 1,4-lactone hydrate can be used as a standard agent compared with novel β-glucuronidase inhibitors. D-Saccharic acid 1,4-lactone hydrate possesses anticarcinogenic, detoxifying, and antioxidant properties [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 61278-30-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134453A. | |
| DUN99845 | DUN99845 is a a lifespan-altering agent. DUN99845 was first reported in patent US 20090163545. DUN99845 was also reported as a STING inhbiitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING-mediated disease. Group: Inhibitors. Alternative Names: DUN99845; DUN-99845; DUN 99845. CAS No. 727699-84-5. Molecular formula: C26H21FN2O4S. Mole weight: 476.52. Appearance: Solid powder. Purity: >98%. IUPACName: N-[3-[[(4-Fluorophenyl)sulfonyl]amino]-4-methoxyphenyl][1,1'-biphenyl]-4-carboxamide. Canonical SMILES: O=C (C1=CC=C (C2=CC=CC=C2)C=C1)NC3=CC=C (OC)C (NS (=O) (C4=CC=C (F)C=C4)=O)=C3. Catalog: ACM727699845. | |
| EDA-GTP - ATTO-620 | EDA-GTP - ATTO-620 is a fluorescent dye used for labeling GTP. It is widely used in biomedical research to study GTPase activity and dynamics in various signaling pathways. Also used in drug discovery, particularly in screening for inhibitors targeting GTPases, which are implicated in many diseases such as cancer and neurodegenerative disorders. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Guanosine-5'-triphosphate, labeled with ATTO 620, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C13H22N7O15P3- ATTO 620 (free acid). Mole weight: 1102.27 (free acid). | |
| Elsulfavirine | Elsulfavirine is a reverse transcriptase inhibitors for HIV-1 infection and is a new anti-HIV agent [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R-1206. CAS No. 868046-19-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109056. | |
| Eriodictyol | Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol induces Nrf2 signaling pathway. Eriodictyol is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 18 nM. Group: Inhibitors. Alternative Names: (S)-3',4',5,7-Tetrahydroxyflavanone. CAS No. 552-58-9. Molecular formula: C12H21NO8S. Mole weight: 339.36. Appearance: White solid. Purity: 0.99. IUPACName: (2S)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one. Canonical SMILES: C1C (OC2=CC (=CC (=C2C1=O)O)O)C3=CC (=C (C=C3)O)O. Density: 1.336±0.06 g/cm³. Catalog: ACM552589. | |
| Fangchinoline | Fangchinoline is isolated fromStephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel HIV-1 inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing. Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK. Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer. Group: Inhibitors. Alternative Names: 12-O-Methylatherospermoline. CAS No. 436-77-1. Mole weight: 608.7. Purity: 98%+. Catalog: ACM436771. | |
| FaX-IN-1 | FaX-IN-1 (compound 11A) is an intermediate in the preparation of FaX inhibitors and was used to study the inhibitory activity against venous thrombosis in rats [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 503614-91-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-75680. | |
| Floxuridine | Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis. Floxuridine has antiviral effects against HSV and CMV. Group: Inhibitors. Alternative Names: 1-beta-d-2'-deoxyribofuranosyl-5-flurouracil;1beta-D-2-Deoxyribofuranosyl-5-fluorouracil;2'-deoxy-5-fluoro-uridin;5-fluor-1-(beta-2'-deoxyribofuranosyl)pyrimidin-2,4(1h,3h)-dion;5-Fluor-1-(beta-2-deoxyribofuranosyl)pyrimidin-2,4(1H,3H)-dion;5-Fluoro-2-deoxyiridine;5-Fluorouracil 2-deoxyriboside;5-Fluorouracil deoxyriboside. CAS No. 50-91-9. Molecular formula: C9H11FN2O5. Mole weight: 246.19. Purity: 0.9995. Catalog: ACM50919. | |
| Fluorofenidone | Fluorofenidone is a NADPH-oxidase inhibitor. Fluorofenidone Inhibits UUO/IRI-Induced Renal Fibrosis by Reducing Mitochondrial Damage. Fluorofenidone protects liver against inflammation and fibrosis by blocking the activation of NF-κB pathway. Fluorofenidone attenuates paraquat - induced pulmonary fibrosis by regulating the PI3K/Akt/mTOR signaling pathway and autophagy. Fluorofenidone inhibits apoptosis of renal tubular epithelial cells in rats with renal interstitial fibrosis. Group: Inhibitors. CAS No. 848353-85-5. Molecular formula: C12H10FNO. Mole weight: 203.22. Appearance: Solid powder. Purity: >98%. IUPACName: 1-(3-Fluorophenyl)-5-methylpyridin-2-one. Canonical SMILES: O=C1C=CC(C)=CN1C2=CC=CC(F)=C2. Catalog: ACM848353855. | |
| γ-Linolenic Acid methyl ester | γ-Linolenic Acid methyl ester (Methyl GLA) is an esterified version of γ-Linolenic Acid (GLA), which is an ω-6 fatty acid, serves as melanoma cell proliferation inhibitors. γ-Linolenic Acid methyl ester inhibits ADP-induced blood platelet aggregation and induces apoptosis [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Methyl GLA. CAS No. 16326-32-2. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-W009276. | |
| Ganoderol A | Ganoderol A is a terpenoid extracted from Ganoderma lucidum with antimicrobial activities. Ganoderol A inhibits cholesterol synthesis pathway and has significant anti-inflammatory activity and protection against ultraviolet A (UVA) damage. Group: Inhibitors. CAS No. 104700-97-2. Molecular formula: C30H46O2. Mole weight: 438.7. Appearance: Powder. Purity: 0.98. IUPACName: (10S,13R,14R,17S)-17-[(E,2R)-7-hydroxy-6-methylhept-5-en-2-yl]-4,4,10,13,14-pentamethyl-1,2,5,6,12,15,16,17-octahydrocyclopenta[a]phenanthren-3-one. Canonical SMILES: CC (CCC=C (C)CO)C1CCC2 (C1 (CC=C3C2=CCC4C3 (CCC (=O)C4 (C)C)C)C)C. Catalog: ACM104700972. | |
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