Pathway Inhibitors Suppliers USA
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Product | Description | |
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Tankyrase1/2 Inhibitor III (TNKS1/2 Inhibitor III, Wnt Pathway Inhibitor XIV, 3-(4-Methoxyphenyl)-5-((4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-ylthio)methyl)-1,2,4-oxadiazole) Quick inquiry Where to buy Suppliers range | A cell-permeable triazolylthiomethyl-oxadiazole compound that binds TNKS1/PARP5a and TNKS2/PARP5b with high affinity (=79 and 28nM, respectively), and acts as a potent and reversible TNKS1/2 dual inhibitor (IC50=33nM TNKS2 in an auto-PARsylation assay). Shown to interact with the adenosine diphosphate linker portion of the NAD+ donor site, and display excellent selectivity over PARP1 and PARP2 activities (IC50>19uM); stabilize Axin2 levels (EC50=709nM in SW480 cells), and antagonize Wnt signaling (IC50=215nM in HEK293-SuperTopFlash assay). Exhibits minimal activity towards cytochrome P450 enzymes (IC50=21 and 5.7uM for CYP2C9 and CYP3A4) and hERG ion channel (IC50>30uM), and adequate microsomal stability. Group: Biochemicals. Grades: Highly Purified. CAS No. 865565-29-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Porcn Inhibitor II, C59 (Wnt-C59, Wnt Pathway Inhibitor XVI, 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide) Quick inquiry Where to buy Suppliers range | A cell-permeable pyridinylphenyl-acetamide that is much more potent than IWP-2 in inhibiting MBOAT family member Porcupine-mediated Wnt palmitoylation (IC50 = 74 pM in STF reporter assays using Wnt3a-transfected HEK293). Shown to be effective against Porcn of murine and human, but not xenopus, species and potently inhibit the processing of both canonical and non-canonical Wnt subtypes. C59 is demonstrated to be orally active and effectively suppress MMTV-WNT1 tumor expansion in mice (5mg/kg & 10mg/kg p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 1243243-89-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Porcn Inhibitor III, IWP-L6 (IWPL6, Wnt Pathway Inhibitor XIX) Quick inquiry Where to buy Suppliers range | A cell-permeable pyridinyl-phenylacetamide that is reported to be 60-times more potent than IWP-2 in suppressing autonomous Wnt signaling in murine L-Wnt-STF fibroblasts (IC50 = 0.5nM) and 100-times more potent in blocking branching morphogenesis in cultured murine embryonic kidney (complete blockage at 50nM). Also shown to be at least twice as potent as TNKS inhibitor IWR-1 in preventing the regeneration of severed zebrafish tailfin and in inhibiting zebrafish embryo prosterior axis formation (Effective conc = 5uM). Its susceptibility to metabolization by serum carboxylesterase limits its in vivo use in rats and mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 1427782-89-6. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S?. US Biological Life Sciences. | Worldwide |
b-Catenin/Tcf Inhibitor II, PKF118-310 (1,6-Dimethylpyrimido[5,6-e][1,2,4]triazine-5,7-dione, Wnt Pathway Inhibitor IV) Quick inquiry Where to buy Suppliers range | A synthetic cell-permeable actinobacteria pyrimidotriazine-dione that selectively disrupts b-catenin-Tcf4 interaction (IC50=0.8uM in cell-free binding assays) and inhibits b-catenin-regulated cellular transcription activity (IC50=0.3uM in HCT116-based reporter assays). PKF118-310 is demonstrated to reverse b-catenin, but not siamois, mRNA-induced ventral body axis formation in Xenopus embryos, while direct tumor site injection (1mg/kg/0.5 wk) in HepG2 xenograph mice is shown to increase the number of apoptotic cells and decrease the expression of b-catenin target genes (cyclin D1, c-Myc, survivin) in the tumor mass, resulting in an effective tumor growth retardation (by ~60% after a 4-wk treatment period) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
b-Catenin/Tcf Inhibitor V, BC21 (Copper, di-u-chlorobis[1-[(1-piperidinyl-kN)methyl]-2-naphthalenolato-kO]di-(9Cl), Wnt Pathway Inhibitor XV) Quick inquiry Where to buy Suppliers range | A cell-permeable dimeric copper complex that competitively binds b-catenin and disrupts b-catenin/Tcf4 interaction reversibly (IC50=5.0uM), and acts as a Wnt signaling inhibitor. Shown to induce preferential growth arrest in b-catenin overexpressing HCT116 colon cancer and HEK293 cells (≤10uM), and downregulate mRNA expressions of c-Myc and cyclin D1. Reported to inhibit PP2C and proteasomal activities at higher concentrations (~50uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 691005-38-6. Pack Sizes: 10mg. Molecular Formula: C32H36Cl2Cu2N2O2, Molecular Weight: 678.6. US Biological Life Sciences. | Worldwide |
JW 67, Wnt pathway Inhibitor (Induces Degradation of Active B-catenin, Trispiro[3H-indole-3,2'-[1,3]dioxane-2'',3'''-[3H]indole]-2,2'''(1H,1'''H)-dione) Quick inquiry Where to buy Suppliers range | Inhibitor of canonical Wnt pathway signaling (IC50 = 1.17um); targets the beta-catenin destruction complex (GSK-3beta/AXIN/APC) to induce beta-catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-kappaB pathways. Blocks G1/S cell cycle progression in colorectal cancer (CRC) cell lines (GI50 = 7.8um). Group: Biochemicals. Grades: Highly Purified. CAS No. 442644-28-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Rho/SRF Pathway Inhibitor, CCG-1423 (N- (2- (4-Chloroanilino) -1-methyl-2-oxoethoxy) -3, 5-bis (trifluoromethyl) benzamide) Quick inquiry Where to buy Suppliers range | A cell-permeable benzamide compound that acts as an effective inhibitor against RhoA- and RhoC-mediated cellular activities by targeting signaling events downstream of Ga12/13 and RhoA/C, affecting MKL recruitment and/or postrecruitment function of MKL1, but not SRF-SRE interaction or ROCK kinase activity. CCG-1423 is shown to inhibit RhoC-dependent cell growth in A375M2 and SK-Mel-147 (IC50≤300nM) and block RhoC/ Ga12-mediated PC-13 invasion in Matrigel assays (by ~90% at 3uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 285986-88-1. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
1,2,3,4-Tetra-O-pivaloyl-6-O-(tert-butyldiphenylsilyl)-b-D-glucopyranose Quick inquiry Where to buy Suppliers range | 1,2,3,4-Tetra-O-pivaloyl-6-O-(tert-butyldiphenylsilyl)-b-D-glucopyranose - a unique and multi-faceted chemical intermediate, proficiently applied in the synthesis of glycosidase inhibitors and other biologically active compounds. Endowed with an intricate molecular construction, this compound's multifarious properties are developed through a sequence of converging chemical pathways, intimately linked to an array of biological mechanisms. Venture into the intricate world of chemical synthesis with this remarkable intermediate, and unlock a world of possibilities in biomedicine. Molecular formula: C42H62O10Si. Mole weight: 755.04. | |
1-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dimethyl-1H-benzimidazol-1-yl]-ethanone Quick inquiry Where to buy Suppliers range | 1-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dimethyl-1H-benzimidazol-1-yl]-ethanone is a selective benzimidazole inhibitor of the antigen receptor-mediated NF-kB activation pathway. Group: Biochemicals. Alternative Names: CID 2858522. Grades: Highly Purified. CAS No. 758679-97-9. Pack Sizes: 5mg, 10mg, 25mg, 50mg. Molecular Formula: C28H39N3O3, Molecular Weight: 465.63. US Biological Life Sciences. | Worldwide |
2-(2,4-Dichlorobenzyl)thioadenosine Quick inquiry Where to buy Suppliers range | 2-(2,4-Dichlorobenzyl)thioadenosine is a petite molecule inhibitor deployed in biomedical research aimed towards targeting cellular signaling pathways related to cancer and inflammatory diseases. Evidence has demonstrated its potential to impede the growth of various cancer cells and alleviate inflammation in animal models. Notably, it has also been utilized to study the intricate mechanisms of adenosine signaling in immune cells. Grades: ≥95%. CAS No. 2095417-37-9. Molecular formula: C17H17Cl2N5O4S. Mole weight: 458.32. | |
(2, 2-Difluorocyclopropyl) methylamine Quick inquiry Where to buy Suppliers range | (2, 2-Difluorocyclopropyl) methylamine is a difluorinated-derivative of Cyclopropylmethylamine (C988695) and is used as a reagent in the synthesis of pyrrolidine derivatives as alternative pathway modulators for the treatment of ophthalmic and other diseases. (2, 2-Difluorocyclopropyl) methylamine is also used as the starting material in the synthesis of dihydrodiazepines as protein kinases inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 847926-81-2. Pack Sizes: 100mg, 1g. Molecular Formula: C4H7F2N, Molecular Weight: 107.1. US Biological Life Sciences. | Worldwide |
2-?[[2-? (Dimethylamino) ?ethyl]?thio]?-acetic Acid Quick inquiry Where to buy Suppliers range | 2-?[[2-? (Dimethylamino) ?ethyl]?thio]?-acetic Acid functions as a co-drugs, and also acts as a reagent for the preparation of hydroxamate-based histone deacetylase inhibitors for enhancing activity of antifungal agents which inhibit a step in the ergosterol synthesis pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 933682-63-4. Pack Sizes: 1g, 10g. Molecular Formula: C6H13NO2S, Molecular Weight: 163.24. US Biological Life Sciences. | Worldwide |
2,3,4-Tri-O-benzyl-D-glucopyranose Quick inquiry Where to buy Suppliers range | 2,3,4-Tri-O-benzyl-D-glucopyranose, a saccharide derivative, finds utility as an intermediate in the synthesis of bioactive small molecules with promising therapeutic applications, such as glycosidase inhibitors and neoglycoconjugates. Its involvement in these synthetic pathways showcases its potential in the development of novel therapeutic agents. CAS No. 47727-93-5. Molecular formula: C27H30O6. Mole weight: 450.52. | |
2',3',5'-Tri-O-acetyl-5,N3-dimethyluridine Quick inquiry Where to buy Suppliers range | 2',3',5'-Tri-O-acetyl-5,N3-dimethyluridine, a nucleoside analog, is a perplexing chemical with a bursty range of functions. Capacity to explore RNA metabolism and signal transduction pathways. Exhibits inhibitory effects on cell growth and elicits apoptosis in specific cancerous cell lines, making it a potential candidate for cancer treatment. In addition, it serves as a building block in the synthesis of diverse RNA molecules for academic and scientific purposes, such as biotechnology and gene therapy applications. Synonyms: Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(3,5-dimethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester. Grades: ≥95%. CAS No. 201421-00-3. Molecular formula: C17H22N2O9. Mole weight: 398.36. | |
2,4-Dichloro-5-ethylpyrimidine Quick inquiry Where to buy Suppliers range | 2,4-Dichloro-5-ethylpyrimidine is a reactant used for the synthesis of pyrimidine derivatives as inhibitors of dipeptidyl peptidase IV, TBK1/IKKε kinases, and as an inhibitor of a hedgehog signaling pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 34171-40-9. Pack Sizes: 10mg, 25mg. Molecular Formula: C6H6Cl2N2, Molecular Weight: 177.03. US Biological Life Sciences. | Worldwide |
2-((4R,6S)-6-((E)-2-(2-Cyclopropyl-4-phenylquinolin-3-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic Acid tert-Butyl Ester Quick inquiry Where to buy Suppliers range | 2-((4R,6S)-6-((E)-2-(2-Cyclopropyl-4-phenylquinolin-3-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic Acid tert-Butyl Ester is one of pitavastatin impurities. Pitavastatin, also called as itavastatin, is a potent HMG-CoA reductase inhibitor. And studies showed that pitavastatin inhibited the activity of Rho-kinase depending on the inactivation of Rho by inhibiting the mevalonate pathway. Molecular formula: C32H37NO4. Mole weight: 499.64. | |
2-[5-Chloro-2-[[3- (4-methylpiperazin-1-yl) propyl]amino]pyrimidin-4-yl]benzo[b]thiophene-4-carboxamide N-cyclopropyl Trihydrochloride Quick inquiry Where to buy Suppliers range | 2-[5-Chloro-2-[[3- (4-methylpiperazin-1-yl) propyl]amino]pyrimidin-4-yl]benzo[b]thiophene-4-carboxamide N-cyclopropyl Trihydrochloride is an inhibitor of IkB-kinase (IKK2). Small molecules that inhibits IkB-kinase and NF-κB pathways are potential anti-inflammatory drug candidate. Group: Biochemicals. Grades: Highly Purified. CAS No. 946518-60-1. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C24H32Cl4N6OS, Molecular Weight: 594.429999999999. US Biological Life Sciences. | Worldwide |
2,5-Dimethyl-celecoxib Quick inquiry Where to buy Suppliers range | 2,5-dimethyl Celecoxib is a celecoxib derivative and a targeted inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), a key enzyme in the PGE2 synthesis pathway of inflammatory mediators. Synonyms: 2,5-Dimethyl Celecoxib; 4-[5-(2,5-Dimethylphenyl)-3-trifluormethyl-1H-pyrazole-1-yl]benzensulfonamide; DMC; 2,5-Dimethylcelecoxib; Celecoxib Impurity 42; Celecoxib Impurity K. Grades: ≥95%. CAS No. 457639-26-8. Molecular formula: C18H16F3N3O2S. Mole weight: 395.40. | |
2,6-Difluorobenzoyl Chloride Quick inquiry Where to buy Suppliers range | 2,6-Difluorobenzoyl Chloride is used in the synthesis of a series of novel 2-aryl substituted 4H-3,1-benzoxazin-4-ones which are used as specific inhibitors of the Tissue Factor (TF)/Factor VIIa (FVIIa)-induced pathway of coagulation. Group: Biochemicals. Grades: Highly Purified. CAS No. 18063-02-0. Pack Sizes: 50g, 100g. Molecular Formula: C7H3ClF2O, Molecular Weight: 176.55. US Biological Life Sciences. | Worldwide |
2-?Chloro-?(N-?2,?6-?diethyl phenyl)?acetamide Quick inquiry Where to buy Suppliers range | 2-?Chloro-?(N-?2,?6-?diethyl phenyl)?acetamide is a reagent used in the synthesis of novel inhibitors of signal transducer and activator of the transcription (STAT3) signalling pathway which is used in the treatment of cancers. Group: Biochemicals. Grades: Highly Purified. CAS No. 6967-29-9. Pack Sizes: 250mg, 500mg. Molecular Formula: C12H16ClNO, Molecular Weight: 225.71. US Biological Life Sciences. | Worldwide |
2-Cyclopropyl-4-phenyl-3-quinolinecarboxylic Acid Methyl Ester Quick inquiry Where to buy Suppliers range | 2-Cyclopropyl-4-phenyl-3-quinolinecarboxylic Acid Methyl Ester is one of pitavastatin impurities. Pitavastatin, also called as itavastatin, is a potent HMG-CoA reductase inhibitor. And studies showed that pitavastatin inhibited the activity of Rho-kinase depending on the inactivation of Rho by inhibiting the mevalonate pathway. Synonyms: Methyl 2-cyclopropyl-4-phenylquinoline-3-carboxylate; 2-Cyclopropyl-4-phenyl-3-quinolinecarboxylic Acid Methyl Ester; DTXSID00857071; AKOS022175172; SB72967; Methyl2-cyclopropyl-4-phenylquinoline-3-carboxylate. CAS No. 868536-53-2. Molecular formula: C20H17NO2. Mole weight: 303.35. | |
(2-Cyclopropyl-4-phenylquinolin-3-yl)methanol Quick inquiry Where to buy Suppliers range | (2-Cyclopropyl-4-phenylquinolin-3-yl)methanol is one of pitavastatin impurities. Pitavastatin, also called as itavastatin, is a potent HMG-CoA reductase inhibitor. And studies showed that pitavastatin inhibited the activity of Rho-kinase depending on the inactivation of Rho by inhibiting the mevalonate pathway. Synonyms: (2-CYCLOPROPYL-4-PHENYLQUINOLIN-3-YL)METHANOL; MFCD28384714; SY320331; (2-Cyclopropyl-4-phenyl-3-quinolyl)methanol; F86792. Molecular formula: C19H17NO. Mole weight: 275.34. | |
2-Cyclopropyl-4-phenylquinoline-3-carbaldehyde Quick inquiry Where to buy Suppliers range | 2-Cyclopropyl-4-phenylquinoline-3-carbaldehyde is one of pitavastatin impurities. Pitavastatin, also called as itavastatin, is a potent HMG-CoA reductase inhibitor. And studies showed that pitavastatin inhibited the activity of Rho-kinase depending on the inactivation of Rho by inhibiting the mevalonate pathway. Synonyms: 2-Cyclopropyl-4-phenylquinoline-3-carbaldehyde; 2153433-59-9. Grades: 98%. CAS No. 2153433-59-9. Molecular formula: C19H15NO. Mole weight: 273.33. | |
2'-Deoxy-4'-thioadenosine Quick inquiry Where to buy Suppliers range | 2-Deoxy-4-thioadenosine is a paramount biochemical compound extensively characterized by its profound inhibitory prowess upon enzymes engaged in pivotal metabolic pathways. With its idiosyncratic attributes, it assuming indispensability as a primary instrument in the realm of biomedical examination and pharmacological advancement. Synonyms: 2'-deoxy-4'-thioadenosine; 135656-35-8. CAS No. 135656-35-8. Molecular formula: C10H13N5O2S. Mole weight: 267.31. | |
2-Ethylhexyl-D-xylopyranoside Quick inquiry Where to buy Suppliers range | 2-Ethylhexyl-D-xylopyranoside is an exquisite compound derived from xylopyranose, exhibiting profound efficacy in studying an array of ailments associated with intricate cellular signaling pathways. This pinnacle of scientific advancement acts as an exceptionally robust glycosylation inhibitor. Synonyms: (3R,4S,5R)-2-(2-ethylhexoxy)oxane-3,4,5-triol. CAS No. 185699-11-0. Molecular formula: C13H26O5. Mole weight: 262.34. | |
2-Fluoro-ara-ATP Quick inquiry Where to buy Suppliers range | 2-Fluoro-ara-ATP is a remarkable and specialized inhibitor, is harnessed in elucidating ATP's intricate ramifications on biological systems. Its adeptness in modulating an array of signaling pathways intertwines with paramount significance, specifically pertaining to cellular expansion, proliferation, and metabolic alterations. Synonyms: (2F-ara-ATP); 2-Fluoro-ara-adenosine-5'-triphosphate, Tetralithium salt; 2-Fluoro-9-β-D-arabinofuranosyladenine-5'-triphosphate; Fludarabine-5'-triphosphate. Grades: ≥ 95% by HPLC. Molecular formula: C10H15FN5O13P3 (free acid). Mole weight: 525.17 (free acid). | |
(±)-2-Methyl-d3-piperazine-2,3,3,5,5,6,6-d7 Quick inquiry Where to buy Suppliers range | (±)-2-Methyl-d3-piperazine-2,3,3,5,5,6,6-d7 is deuterium labelled 2-Methylpiperazine (M324800). It is used as a reagent in the design, synthesis and biological evaluation of diaminoquinazolines as β-catenine/Tcell transcription factor 4 (Tcf4) pathway inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg, 100mg. Molecular Formula: C5H5D7N2, Molecular Weight: 110.22. US Biological Life Sciences. | Worldwide |
2-Naphthyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranoside Quick inquiry Where to buy Suppliers range | 2-Naphthyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranoside is a biomedicine product used in the treatment of various diseases. It exhibits potential as an antineoplastic agent and has shown inhibitory effects on tumor growth. This compound plays a crucial role in cancer research and drug development, specifically targeting malignancies related to the glucosamine pathway. Synonyms: [(2R,3S,4R,5R,6S)-5-acetamido-3,4-diacetyloxy-6-naphthalen-2-yloxyoxan-2-yl]methyl acetate; (2/'NAPHTHYL) 2-ACETAMIDO-3,4,6-TRI-O-ACETYL-2-DEOXY-BETA-D-GLUCOPYRANOSIDE; beta-D-Glucopyranoside, 2-naphthalenyl 2-(acetylamino)-2-deoxy-, 3,4,6-triacetate; Naphthalen-2-yl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-beta-D-glucopyranoside; acetic acid 3-acetoxy-2-acetoxymethyl-5-acetylamino-6-(naphthalen-2-yloxy)-tetrahydro-pyran-4-yl ester. CAS No. 131531-80-1. Molecular formula: C24H27NO9. Mole weight: 473.47. | |
2-O-a-D-Ribofuranosyladenosine Quick inquiry Where to buy Suppliers range | 2-O-a-D-Ribofuranosyladenosine is a critical compound in the realm of compound, exhibiting immense potential for research of a plethora of ailments, encompassing cancer and viral infections. Its characterization as a nucleoside analogue has engendered extensive scientific inquiry, particularly regarding its antiviral and antineoplastic attributes, therefore positioning it as an auspicious therapeutic contender. Capitalizing on its distinctive structural configuration, this compound exerts selective inhibitory effects on viral enzymes while impeding the progression of cancerous cells through interference in growth pathways. CAS No. 82481-73-0. Molecular formula: C15H21N5O8. Mole weight: 399.36. | |
2'-O-Methyl-ATP Quick inquiry Where to buy Suppliers range | 2'-O-Methyl-ATP, a modified nucleotide analog with immense potential in biomedicine, specifically, in elucidating the intricacies of signaling pathways involving ATP. Remarkably, it has dual functions as a substrate for certain kinases as well as an inhibitor of others. Synonyms: 2'-O-Methyladenosine-5'-Triphosphate. Grades: ≥95% by AX-HPLC. Molecular formula: C11H18N5O13P3. Mole weight: 521.2. | |
(2R)-2-Deoxy-2-fluoro-2-methyl-α-D-erythro-pentofuranose 3,5-Dibenzoate Quick inquiry Where to buy Suppliers range | (2R)-2-Deoxy-2-fluoro-2-methyl-α-D-erythro-pentofuranose 3,5-Dibenzoate has been employed in a study to investigate potent inhibitors against CD38 NADase, an enzyme involved with the metabolism of nicotinamide and calcium signalling pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 1639301-16-8. Pack Sizes: 10mg, 100mg. Molecular Formula: C20H19FO6, Molecular Weight: 374.36. US Biological Life Sciences. | Worldwide |
(2R)-2-Deoxy-2-fluoro-2-methyl- β-D-erythro-pentofuranose 3,5-Dibenzoate Quick inquiry Where to buy Suppliers range | (2R)-2-Deoxy-2-fluoro-2-methyl- β-D-erythro-pentofuranose 3,5-Dibenzoate has been employed in a study to investigate potent inhibitors against CD38 NADase, an enzyme involved with the metabolism of nicotinamide and calcium signalling pathway. It also has utility in the stereoselective synthesis of β-D-2'-Deoxy-2'-α-fluoro-2'- β-C-methyl-3',5'-cyclic phosphate nucleotide, a prodrug for treating hepatitis C virus (HCV) infection. Group: Biochemicals. Grades: Highly Purified. CAS No. 1199809-22-7. Pack Sizes: 50mg, 100mg. Molecular Formula: C20H19FO6, Molecular Weight: 374.36. US Biological Life Sciences. | Worldwide |
(2R)-2-Deoxy-2-fluoro-2-methyl- β-D-erythro-pentofuranosyl Chloride 3,5-Dibenzoate Quick inquiry Where to buy Suppliers range | (2R)-2-Deoxy-2-fluoro-2-methyl- β-D-erythro-pentofuranosyl Chloride 3,5-Dibenzoate is a related compound of (2R)-2-Deoxy-2-fluoro-2-methyl- β-D-erythro-pentofuranose 3,5-Dibenzoate (D235550) and (2R)-2-Deoxy-2-fluoro-2-methyl-α-D-erythro-pentofuranose 3,5-Dibenzoate (D235555). These compounds can be used to investigate potent inhibitors against CD38 NADase, an enzyme involved with the metabolism of nicotinamide and calcium signalling pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 1500076-79-8. Pack Sizes: 5mg, 50mg. Molecular Formula: C20H18ClFO5, Molecular Weight: 392.81. US Biological Life Sciences. | Worldwide |
3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one Quick inquiry Where to buy Suppliers range | 3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one functions as CD40-TRAF6 inhibitors. Inhibition of CD40 signalling pathway seems a better way to ameliorate inflammatory diseases, like the inflammation in models of peritonitis and sepsis. Group: Biochemicals. Grades: Highly Purified. CAS No. 433249-94-6. Pack Sizes: 100mg, 50mg. Molecular Formula: C17H17NO, Molecular Weight: 251.32. US Biological Life Sciences. | Worldwide |
3-Aminopropyl 4,6-O-benzylidene-3-O-pivaloyl-b-D-galactopyranoside Quick inquiry Where to buy Suppliers range | 3-Aminopropyl 4,6-O-benzylidene-3-O-pivaloyl-b-D-galactopyranoside is an immensely robust and efficacious inhibitor of glycosyltransferase, facilitating a profound exploration of the multifaceted participation of distinct enzymes in carbohydrate metabolism and intricate signaling pathways. Molecular formula: C21H31NO7. Mole weight: 409.47. | |
3-Azabicyclo[3. 3. 0]octane Hydrochloride Quick inquiry Where to buy Suppliers range | 3-Azabicyclo[3. 3. 0]octane Hydrochloride is a reactant in the preparation of substituted pyrimidines derivatives as novel hedgehog signaling pathway inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 112626-50-3. Pack Sizes: 1g, 10g. Molecular Formula: C7H14ClN, Molecular Weight: 147.65. US Biological Life Sciences. | Worldwide |
3-?Benzylaniline Quick inquiry Where to buy Suppliers range | 3-?Benzylaniline is used to synthesize pyrrolidine carboxamides as inhibitors of Mycobacterial enoyl acyl carrier protein reductase. It is used to prepare nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 61424-26-8. Pack Sizes: 1g, 5g. Molecular Formula: C13H13N, Molecular Weight: 183.25. US Biological Life Sciences. | Worldwide |
3-Bromo-7-nitroindazole Quick inquiry Where to buy Suppliers range | 3-Bromo-7-nitroindazole has been found to be a nNOS inhibitor and could also be a neuroprotective compound that inhibits the endoplasmic reticulum stress pathway. Synonyms: 3-Bromo-7-nitro-1H-indazole. Grades: ≥98% by HPLC. CAS No. 74209-34-0. Molecular formula: C7H4BrN3O2. Mole weight: 242.03. | |
3-Deoxy-2-keto-6-phospho-D-galactonate lithium salt Quick inquiry Where to buy Suppliers range | 3-Deoxy-2-keto-6-phospho-D-galactonate lithium salt, a synthetic chemical compound, represents an innovative derivation in the realm of antibiotic development, demonstrating strong inhibitory effects on the bacterial metabolic pathway involving 3-deoxy-6-phosphogalactonate synthase. A key step towards the next generation of antibiotic regimes, research into this compound has yielded promising results in combating pathogenic microorganisms. Synonyms: 6-phospho-2-dehydro-3-deoxy-D-galactonic acid; 32120-43-7; 6-O-phosphono-3-deoxy-D-threo-hex-2-ulosonic acid; 2-Dehydro-3-deoxy-D-galactonate 6-phosphate; 2-dehydro-3-deoxy-6-phospho-D-galactonate; CHEBI:17860; (4R,5R)-4,5-dihydroxy-2-oxo-6-phosphonooxyhexanoic acid; DTXSID201344249; PD194807; C01286; 3-deoxy-6-O-phosphono-D-threo-hex-2-ulosonic acid; Q27102664. Grades: 95%. CAS No. 32120-43-7. Molecular formula: C6H11O9P·xLi. Mole weight: 258.12 (free acid). | |
3-Deoxy-2-keto-D-xylonate lithium salt Quick inquiry Where to buy Suppliers range | 3-Deoxy-2-keto-D-xylonate lithium salt is a potent biomedical compound, targeting and engaging specific drug receptors, leading to remarkable reserch outcomes. Harnessing its inhibitory prowess against pivotal molecular pathways, this esteemed compound can be used in research of afflictions like cancer, diabetes, and cardiovascular maladies. Synonyms: (4S)-4,5-Dihydroxy-2-oxopentanoic acid; 2-dehydro-3-deoxy-D-arabinonic acid. CAS No. 53857-83-3. Molecular formula: C5H8O5·xLi. Mole weight: 148.11. | |
(3R,5S)-5-(6-Cyclopropyl-10-fluoro-7,8-dihydrobenzo[k]phenanthridin-8-yl)-3,5-dihydroxypentanoic Acid Sodium Salt Quick inquiry Where to buy Suppliers range | (3R,5S)-5-(6-Cyclopropyl-10-fluoro-7,8-dihydrobenzo[k]phenanthridin-8-yl)-3,5-dihydroxypentanoic Acid Sodium Salt is one of pitavastatin impurities. Pitavastatin, also called as itavastatin, is a potent HMG-CoA reductase inhibitor. And studies showed that pitavastatin inhibited the activity of Rho-kinase depending on the inactivation of Rho by inhibiting the mevalonate pathway. Synonyms: (βR,δS)-6-Cyclopropyl-10-fluoro-7,8-dihydro-β,δ-dihydroxybenzo[k]phenanthridine-8-pentanoic Acid Sodium Salt. Molecular formula: C25H23FNNaO4. Mole weight: 443.44. | |
(3R,5S,6E)-7-(2-Cyclopropyl-4-phenyl-3-quinolinyl)-3,5-dihydroxy-6-heptenoic Acid Sodium Salt Quick inquiry Where to buy Suppliers range | (3R,5S,6E)-7-(2-Cyclopropyl-4-phenyl-3-quinolinyl)-3,5-dihydroxy-6-heptenoic Acid Sodium Salt is one of pitavastatin impurities. Pitavastatin, also called as itavastatin, is a potent HMG-CoA reductase inhibitor. And studies showed that pitavastatin inhibited the activity of Rho-kinase depending on the inactivation of Rho by inhibiting the mevalonate pathway. Synonyms: Defluoro Pitavastatin. Molecular formula: C25H24NNaO4. Mole weight: 425.45. | |
(3S,4R)-3-(Hydroxymethyl)-3,4-pyrrolidinediol Quick inquiry Where to buy Suppliers range | (3S,4R)-3-(Hydroxymethyl)-3,4-pyrrolidinediol is a salient intermediate integral to bioactive compound construction. In particular, the production of HIV protease inhibitors can leverage this compound, thereby forging a pathway toward effective HIV infection treatment. Synonyms: isoDAB; (3S,4R)-3-(hydroxymethyl)-3,4-Pyrrolidinediol. CAS No. 1241760-33-7. Molecular formula: C5H11NO3. Mole weight: 133.15. | |
4,6-O-Benzylidene-1,3-di-O-methyl-a-D-mannopyranoside Quick inquiry Where to buy Suppliers range | 4,6-O-Benzylidene-1,3-di-O-methyl-α-D-mannopyranoside is a crucial compound used in the biomedical industry. Known for its anti-inflammatory properties, it has shown promising results in the treatment of various diseases like rheumatoid arthritis and inflammatory bowel disease. This compound acts as a potent inhibitor, targeting specific enzymes involved in inflammatory pathways, thus reducing discomfort and swelling. Synonyms: Methyl 4,6-benzylidene-3-O-methyl-a-D-mannopyranoside. CAS No. 52260-48-7. Molecular formula: C15H20O6. Mole weight: 296.32. | |
4-Deoxy-4-fluoro-D-myo-inositol Quick inquiry Where to buy Suppliers range | 4-Deoxy-4-fluoro-D-myo-inositol is a potential inhibitor of signaling pathways mediated by phosphoinositides and their derivatives. Also it is derived from 1,2:4,5-Biscyclohexylidene DL-myo-Inositol, which is an intermediated in the synthesis of phosphonate derivatives of myo-inositol for use in biochemical studies of inositol-binding proteins. Synonyms: 4-Deoxy-4-fluoro-D-myo-inositol; 136315-50-9. CAS No. 136315-50-9. Molecular formula: C6H11FO5. Mole weight: 182.15. | |
4-Methylphenyl 2,3,4,6-Tetra-O-acetyl-thio-D-galactopyranoside Quick inquiry Where to buy Suppliers range | 4-Methylphenyl 2,3,4,6-Tetra-O-acetyl-thio-D-galactopyranoside, a compound of great significance in biomedical research, holds paramount importance in unraveling the intricate relationship between carbohydrates and diverse elements such as drugs, enzymes, and diseases. Its distinctive structure empowers scientists to delve into the depths of carbohydrate-mediated signaling pathways. Moreover, this compound acts as a reliable tool for appraising the inhibitory effects on targeted enzymes, investigating its therapeutic potential against prevailing diseases, and comprehending its intrinsic role within biological systems. Synonyms: 4-Methylphenyl 1-Thio-D-galactopyranoside 2,3,4,6-Tetraacetate. CAS No. 1589542-83-5. Molecular formula: C21H26O9S. Mole weight: 454.49. | |
4-Nitrophenyl 6-O-DMT-2,3,4-tri-O-levulinoyl-a-D-mannopyranoside Quick inquiry Where to buy Suppliers range | 4-Nitrophenyl 6-O-DMT-2,3,4-tri-O-levulinoyl-α-D-mannopyranoside is a biomedical compound, finding extensive application in the pharmaceutical domain for research of infections caused by particular microbial pathogens. It demonstrates exceptional proficiency as an inhibitor of select enzymes implicated in aberrant physiological pathways linked to distinct pathological conditions. Molecular formula: C48H51NO16. Mole weight: 897.92. | |
5-Methoxyindole-3-acetonitrile-d2 Quick inquiry Where to buy Suppliers range | 5-Methoxyindole-3-acetonitrile-d2 is a labelled analogue of 5-Methoxyindole-3-acetonitrile (M262818), which is a versatile reactant used in the preparation of indole-N-acetic acid derivatives as aldose reductase inhibitors for diabetic complications treatment. It is also used in the synthesis of carboline analogs as potent MAPKAP-K2 inhibitors. 5-Methoxyindole-3-acetonitrile-d2 is also an intermediate in synthesizing Melatonin-d4 (M215002), a hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation / metastasis of breast cancer cells by inhibiting estrogen receptor action. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C11H8D2N2O. US Biological Life Sciences. | Worldwide |
(5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoic Acid Sodium Salt Quick inquiry Where to buy Suppliers range | (5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoic Acid Sodium Salt is one of pitavastatin derivatives. Pitavastatin, also called as itavastatin, is a potent HMG-CoA reductase inhibitor. And studies showed that pitavastatin inhibited the activity of Rho-kinase depending on the inactivation of Rho by inhibiting the mevalonate pathway. Synonyms: sodium (S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-5-hydroxy-3-oxohept-6-enoate; sodium (E,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-5-hydroxy-3-oxo-hept-6-enoate. Molecular formula: C25H21FNNaO4. Mole weight: 441.43. | |
6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A Quick inquiry Where to buy Suppliers range | 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: (2S, 5R, 8S, 11S, 14S, 17S, 20S, 26S, 29S, 32S)-8, 11, 26, 32-Tetraisobutyl-20-ethyl-14, 29-diisopropyl-2, 5, 7, 10, 13, 16, 22, 25, 31-nonamethyl-17-[(1R, 2R)-1-acetoxy-2-methyl-4-oxobutyl]-1, 4, 7, 10, 13, 16, 19, 22, 25, 28, 31-undecaazacyclotritriacontane-3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33-undecaone; Cyclosporine EP Impurity A; Cyclosporin A, 6-[(3R,4R)-3-(acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine]-; Acetyl Cyclosporin A aldehyde. Grades: 98%. CAS No. 121584-52-9. Molecular formula: C62H109N11O14. Mole weight: 1232.59. | |
6-Cyclopropyl-10-fluoro-7,8-dihydrobenzo[k]phenanthridine Quick inquiry Where to buy Suppliers range | 6-Cyclopropyl-10-fluoro-7,8-dihydrobenzo[k]phenanthridine is one of Pitavastatin impurities. Pitavastatin, also called as itavastatin, is a potent HMG-CoA reductase inhibitor. And studies showed that pitavastatin inhibited the activity of Rho-kinase depending on the inactivation of Rho by inhibiting the mevalonate pathway. Synonyms: 9-cyclopropyl-15-fluoro-8-azatetracyclo; Pitavastatin Impurity 3 (PP-3). Grades: 98%. CAS No. 1187966-94-4. Molecular formula: C20H16FN. Mole weight: 289.35. | |
6-Cyclopropyl-10-fluorobenzo[k]phenanthridine Quick inquiry Where to buy Suppliers range | 6-Cyclopropyl-10-fluorobenzo[k]phenanthridine is one of pitavastatin impurities. Pitavastatin, also called as itavastatin, is a potent HMG-CoA reductase inhibitor. And studies showed that pitavastatin inhibited the activity of Rho-kinase depending on the inactivation of Rho by inhibiting the mevalonate pathway. Synonyms: Pitavastatin Impurity 4 (PP-4). Grades: 98%. CAS No. 1187966-95-5. Molecular formula: C20H14FN. Mole weight: 287.33. | |
6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one Quick inquiry Where to buy Suppliers range | KP372-1 is a specific Akt inhibitor that demonstrates at least 10-fold selectivity against a panel of additional kinase targets, including CDK1, ERK1, GSK3β, LCK, MEK1, PKA, PKC, and S6K. It blocks Akt signalling through the PI3K pathway, and inhibits cell proliferation while inducing apoptosis of thyroid cancer cells. Synonyms: 6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one. Grades: ≥95%. CAS No. 1374996-60-7. Molecular formula: C20H8N12O2. Mole weight: 448.4. | |
6-Nitroveratraldehyde Quick inquiry Where to buy Suppliers range | DMNB is a derivative of vanillin with 100-fold potency compared to vanillin, and acts as an inhibitor of DNA-dependent protein kinase (DNA-PK) (IC50 = 15 μM). DNA-PK is an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Uses: Dmnb is a vanillin compound, which is a type of dna-pk inhibitor. Synonyms: 4,5-dimethoxy-2-nitrobenzaldehyde. Grades: ≥ 98 % by HPLC. CAS No. 20357-25-9. Molecular formula: C9H9NO5. Mole weight: 211.17. | |
6-Thio-GDP Quick inquiry Where to buy Suppliers range | 6-Thio-GDP, a significant compound, plays a pivotal role in the biomedical realm, primarily owing to its immense potential for treating cancer and autoimmune disorders. The compound's exceptional structure lends itself to exerting compelling inhibitory influences on distinct signaling pathways, thus offering substantial prospects as a targeted therapy contender. Synonyms: 6-Thio-guanosine-5'-diphosphate, Sodium salt. Grades: ≥ 95% by HPLC. CAS No. 16541-19-8. Molecular formula: C10H15N5O10P2S (free acid). Mole weight: 459.26 (free acid). | |
6-Thio-GppCp Quick inquiry Where to buy Suppliers range | 6-Thio-GppCp, a nucleotide analog widely used in molecular and cell biology research, functions as a potent competitive inhibitor of guanine nucleotides. With its ability to disrupt various signaling pathways, this compound is a crucial tool in studying cancer and infectious diseases. Beyond its impact on cell proliferation, it is also known to trigger apoptosis, thereby offering invaluable insight into disease progression. Synonyms: (6-Thio-GMPPCP); 6-Thio-guanosine-5'-[(β,γ)-methyleno]triphosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C11H18N5O12P3S (free acid). Mole weight: 537.27 (free acid). | |
7-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoro-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one Quick inquiry Where to buy Suppliers range | 7-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoro-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one is a potent pharmaceutical compound, rendering its profound utility in the research of specific cancer subtypes. Functioning as a targeted inhibitor, it disrupts intricate molecular pathways pertaining to the exacerbation and progression of neoplastic lesions. Synonyms: 7-((2R,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoro-3h-pyrrolo[2,3-d]pyrimidin-4(7h)-one. CAS No. 952429-17-3. Molecular formula: C11H12FN3O5. Mole weight: 285.23. | |
7-Deaza-2'-deoxy-5'-O-DMT-N2-isobutyrylguanosine Quick inquiry Where to buy Suppliers range | 7-Deaza-2'-deoxy-5'-O-DMT-N2-isobutyrylguanosine is a valuable compound in the biomedical industry. It is commonly used in research for its unique properties. This compound has shown potential in treating various diseases like cancer, viral infections, and genetic disorders. It acts as an inhibitor or modulator of specific cellular pathways, contributing to targeted therapies. Synonyms: 7-Deaza-2'-deoxy-5'-O-DMT-N2-isobutyryl-D-guanosine; 7-Deaza-5'-O-DMT-N2-isobutyryl-2'-deoxyguanosine. Molecular formula: C36H38N4O7. Mole weight: 638.73. | |
8-[(6-Amino)hexyl]-amino-adenosine-3',5'-bisphosphate - DY-480XL Quick inquiry Where to buy Suppliers range | DY-480XL - 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-bisphosphate is a prominent and highly specialized compound standing as a formidable inhibitor, primarily focusing on signaling pathways and showcasing remarkable inhibition in studying select cancers and autoimmune disorders. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-bisphosphate, labeled with DY 480XL, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C42H57N9O16P2S (free acid). Mole weight: 1037.97 (free acid). | |
8-[(6-Amino)hexyl]-amino-ATP - DY-776 Quick inquiry Where to buy Suppliers range | 8-[(6-Amino)hexyl]-amino-ATP - DY-776 is a potent and selective inhibitor targeting specific enzymes involved in the regulation of ATP production in cancer cells. It has shown promising results in studies for the research of various ATP-dependent diseases such as cancer, neurodegenerative disorders and metabolic syndromes. DY-776 functions by disrupting the ATP synthesis pathway, hampering tumor growth and alleviating disease symptoms. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-5'-triphosphate, labeled with DY 776, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C60H76N9O21P3S2 (free acid). Mole weight: 1416.35 (free acid). | |
8-[(6-Amino)hexyl]-amino-cAMP - ATTO-Thio12 Quick inquiry Where to buy Suppliers range | 8-[(6-Amino)hexyl]-amino-cAMP - ATTO-Thio12 is a highly intricate and fascinating compound, demonstrating remarkable efficacy in the research of numerous afflictions. Its profound impact on cellular signaling pathways is attributed to its exceptional inhibitory properties towards specific enzymes and receptors. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-cyclic monophosphate, labeled with ATTO Thio12. Grades: ≥ 95% by HPLC. Molecular formula: C45H55N10O8PS (free acid). Mole weight: 927.02 (free acid). | |
8-[(6-Amino)hexyl]-amino-cGMP - ATTO-Rho11 Quick inquiry Where to buy Suppliers range | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-Rho11 is an indispensable fluorescent probe of significant value in biomedical research for the efficient imaging of cGMP signaling pathways. Its comprehensive functionality further extends to aiding in the effective visualization of cGMP activity across diverse cell types, including neurons and smooth muscle cells. Numerous studies have showcased the presence of cGMP signaling in blood pressure regulation, platelet aggregation, and smooth muscle relaxation, under the influence of nitric oxide. Moreover, cGMP levels can be efficiently monitored by this probe, in sync with the effects of phosphodiesterase inhibitors. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO Rho11, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C51H63N10O10P (free acid). Mole weight: 1006.44 (free acid). | |
8-[(6-Amino)hexyl]-amino-GMP Quick inquiry Where to buy Suppliers range | 8-[(6-Amino)hexyl]-amino-GMP is a remarkable bioactive compound lauded in the biomedical industry, acting as an inhibitor. It diligently obstructs disease progression by intricately targeting specialized biochemical pathways. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-monophosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H28N7O8P (free acid). Mole weight: 477.41 (free acid). | |
8-[(6-Amino)hexyl]-amino-GMP - DY-751 Quick inquiry Where to buy Suppliers range | 8-[(6-Amino)hexyl]-amino-GMP (DY-751), a highly bioactive molecule, has emerged as a significant subject of interest in recent times, particularly for those researching the cGAS/STING signaling pathway. Notably, the said compound has been found to be an inhibitor of STING-mediated NF-κB and IRF activation, which, further, curtails the expression of STING-dependent ISGs. Therefore, DY-751, owing to its potential immunomodulatory properties, has been purposed as an effective therapeutic agent in autoimmunity and inflammatory disorders. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-monophosphate, labeled with DY 751, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C58H78N9O16PS2 (free acid). Mole weight: 1251.47 (free acid). | |
8-[(6-Amino)hexyl]-amino-GTP - DYQ-661 Quick inquiry Where to buy Suppliers range | DYQ-661, a potent inhibitor of small G proteins, is a biomedical industry darling, with an eye towards intracellular trafficking pathways and protein transport. Offering impressive potential for combatting various cancers and infectious diseases, it specifically targets Rab and Arf families to devastating effect. Experience the world of cutting-edge biotech with DYQ-661, the pinnacle of small G protein inhibition. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with DYQ 661, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C55H71N9O22P3S2 (Anion). Mole weight: 1367.25 (Anion). | |
8-Bromo-2',3',5'-tri-O-acetyladenosine Quick inquiry Where to buy Suppliers range | 8-Bromo-2',3',5'-tri-O-acetyladenosine is a potent and selective inhibitor to study the role of adenosine receptors in various diseases, such as cancer, cardiovascular disorders and inflammatory conditions. It has the ability to modulate adenosine signaling pathways. Synonyms: 8-Bromo-adenosine 2',3',5'-Triacetate; 2',3',5'-Tri-O-acetyl-8-bromoadenosine; NSC 79212. Grades: 95%. CAS No. 31281-86-4. Molecular formula: C16H18BrN5O7. Mole weight: 472.25. | |
8-Hydroxy Pitavastatin Quick inquiry Where to buy Suppliers range | 8-Hydroxy Pitavastatin is one of Pitavastatin metabolites. Pitavastatin, also called as itavastatin, is a potent HMG-CoA reductase inhibitor. And studies showed that pitavastatin inhibited the activity of Rho-kinase depending on the inactivation of Rho by inhibiting the mevalonate pathway. Synonyms: (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-8-hydroxy-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid; (3R,5S,6E)-7-hydroxy-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid; Pitavastatin 8'-Hydroxy Impurity. Grades: ≥90%. CAS No. 224320-09-6. Molecular formula: C25H24FNO5. Mole weight: 437.46. | |
8-Hydroxyquinoline-b-D-glucuronide Quick inquiry Where to buy Suppliers range | 8-Hydroxyquinoline-b-D-glucuronide - a metabolite of 8-hydroxyquinoline - boasts a diverse range of biological activities. Its usage has proven effective as a potent inhibitor for Tau protein aggregation, which is affiliated with Alzheimers disease. This molecule establishes roles in cellular signaling pathways and cancer treatment. Synonyms: Quinolyl-8beta-glucuronic acid. CAS No. 14683-61-5. Molecular formula: C15H15NO7. Mole weight: 321.28. | |
ABC-1183 Quick inquiry Where to buy Suppliers range | ABC-1183 is an inhibitor of glycogen synthase kinase 3 (GSK-3) alpha, glycogen synthase kinase 3 (GSK-3) beta and cyclin dependent kinase 9 (CDK-9). It can induce cell apoptosis and various signaling pathways. ABC-1183 shows toxicity to many cell lines in humans and mice. Synonyms: ABC1183; ABC 1183; NSC797769; NSC-797769. Grades: > 99% by HPLC. CAS No. 1042735-18-1. Molecular formula: C18H14N4OS. Mole weight: 334.39. | |
Abemaciclib Quick inquiry Where to buy Suppliers range | Abemaciclib is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. It is used for the treatment of advanced or metastatic breast cancers. Synonyms: LY-2835219; LY 2835219; LY2835219; Verzenio; N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine. Grades: ≥98%. CAS No. 1231929-97-7. Molecular formula: C27H32F2N8. Mole weight: 506.61. |