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| Product | Description | |
|---|---|---|
| 1,6-Dihydro-1-methyl-5-(2-propoxyphenyl)-3-propyl-7H-pyrazolo[4,3-d]pyrimidine-7-thione | 1,6-Dihydro-1-methyl-5-(2-propoxyphenyl)-3-propyl-7H-pyrazolo[4,3-d]pyrimidine-7-thione is an intermediate in the synthesis of analogues of Thiosildenafil (T371500). Propoxyphenyl-thiosildenafil has been used in the preparation of novel pyrazolopyrimidinethio nes as PDE5 inhibitors for treating erectile dysfunction. Group: Biochemicals. Grades: Highly Purified. CAS No. 479074-08-3. Pack Sizes: 25mg, 100mg. Molecular Formula: C18H22N4OS. US Biological Life Sciences. |  Worldwide |
| 1-Methyl-4-nitro-5-propyl-1H-pyrazole-3-carboxamide | Intermediate in the preparation of Iso Viagra and pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction. Group: Biochemicals. Grades: Highly Purified. CAS No. 247583-72-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 1-Methyl-4-nitro-5-propyl-1H-pyrazole-3-carboxylic Acid | Intermediate in the preparation of Iso Viagra and pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction. Group: Biochemicals. Grades: Highly Purified. CAS No. 247583-71-7. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 1-Methyl-5-propyl-1H-pyrazole-3-carboxylic Acid | Intermediate in the preparation of Iso Viagra, Sidenafil analogs and pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction. Group: Biochemicals. Grades: Highly Purified. CAS No. 247583-70-6. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| (1R)?-?1-?(2-?Pyridinyl)?ethanol | (1R)?-?1-?(2-?Pyridinyl)?ethanol is a building block used in the synthesis of highly potent and selective chiral inhibitors of PDE5. Group: Biochemicals. Grades: Highly Purified. CAS No. 27911-63-3. Pack Sizes: 100mg, 250mg. Molecular Formula: C7H9NO, Molecular Weight: 123.15. US Biological Life Sciences. | Worldwide |
| (1R, ?3R)?-1-?(1, ?3-?Benzodioxol-?5-?yl)?-?2, ?3, ?4, ?9-?tetrahydro-1H-?pyrido[3, ?4-?b]?indole-?3-?carboxamide | (1R, ?3R)?-1-?(1, ?3-?Benzodioxol-?5-?yl)?-?2, ?3, ?4, ?9-?tetrahydro-1H-?pyrido[3, ?4-?b]?indole-?3-?carboxamide is an analogue of Tadalafil (T004500), which is a human PDE5 inhibitor. (1R, ?3R)?-1-?(1, ?3-?Benzodioxol-?5-?yl)?-?2, ?3, ?4, ?9-?tetrahydro-1H-?pyrido[3, ?4-?b]?indole-?3-?carboxamide is a weak inhibitor of TbrPDEB1. Group: Biochemicals. Grades: Highly Purified. CAS No. 1370438-57-5. Pack Sizes: 5mg, 10mg. Molecular Formula: C19H17N3O3, Molecular Weight: 335.36. US Biological Life Sciences. | Worldwide |
| (1R,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester | Tadalafil derivative. Used in the preparation of pyrazinopyridoindole derivatives for their PDE5 inhibitory activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 171596-44-4. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| (1S,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester | Tadalafil derivative. Used in the preparation of pyrazinopyridoindole derivatives for their PDE5 inhibitory activity. Group: Biochemicals. Alternative Names: (1S-cis)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester. Grades: Highly Purified. CAS No. 171596-43-3. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 2,2,2-Trifluoroethyl Isocyanate | 2,2,2-Trifluoroethyl Isocyanate is an intermediate used to prepare PDE5 inhibitors for erectile dysfunction. It is also used to synthesize indazolyl glucocorticoid receptor partial agonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 371-92-6. Pack Sizes: 1g, 10g. Molecular Formula: C3H2F3NO. US Biological Life Sciences. | Worldwide |
| 2-Amino-4-methyl-1-propyl-1H-pyrrole-3-carbonitrile | 2-Amino-4-methyl-1-propyl-1H-pyrrole-3-carbonitrile is an impurity of Yonkenafil, a novel phosphodiesterase 5 (PDE5) inhibitor that has a potential therapeutic effect on Alzheimer's disease. Synonyms: 1H-Pyrrole-3-carbonitrile, 2-amino-4-methyl-1-propyl-. Grade: ≥95%. CAS No. 804519-27-5. Molecular formula: C9H13N3. Mole weight: 163.22. |  |
| 2-Ethoxybenzamidine Hydrochloride | An impurity of Vardenafil. Vardenafil is a PDE5 inhibitor used for the treatment of erectile dysfunction. Synonyms: 2-ethoxybenzenecarboximidamide; hydrochloride; 2-ethoxybenzenecarboximidamide; hydrochloride. CAS No. 18637-00-8. Molecular formula: C9H13ClN2O. Mole weight: 200.67. | |
| 2-Ethoxy Benzene carboximidic Acid Hydrazide Hydrochloride | 2-Ethoxy Benzene carboximidic Acid Hydrazide is an impurity of Vardenafil (V098001, 2HCl salt); a selective phosphodiesterase type 5 (PDE5) inhibitor and drug used to treat erectile dysfunction (ED). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C9H13N3O HCi. US Biological Life Sciences. | Worldwide |
| 2-Ethoxy-N'-hydroxy Benzene carboximidamide | 2-Ethoxy-N'-hydroxy Benzene carboximidamide is a reagent used in the synthesis of cyclic pyrimidinones as novel inhibitors for PDE5. Group: Biochemicals. Grades: Highly Purified. CAS No. 879-57-2. Pack Sizes: 100mg, 500mg. Molecular Formula: C9H12N2O2, Molecular Weight: 180.2. US Biological Life Sciences. | Worldwide |
| 2-Formylcyclopropane-1-carboxylic Acid Ethyl Ester | 2-Formylcyclopropane-1-carboxylic Acid Ethyl Ester acts as a reagent for the design, synthesis and biological evaluation of first-in-class dual acting histone deacetylase (HDACs) and phosphodiesterase 5 (PDE5) inhibitors for treatment of Alzheimers disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 20417-61-2. Pack Sizes: 250mg, 500mg. Molecular Formula: C7H10O3, Molecular Weight: 142.15. US Biological Life Sciences. | Worldwide |
| 3- (S) - hydroxypyrrolidinyl avanafil | 3- (S) - hydroxypyrrolidinyl avanafil is a metabolite of Avanafil (A794670), a phosphodiesterase (PDE5) inhibitor, used to treat erectile dysfunction. Group: Biochemicals. Grades: Highly Purified. CAS No. 330785-58-5. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C23H26ClN7O4, Molecular Weight: 499.95. US Biological Life Sciences. | Worldwide |
| 4-Amino-1-methyl-5-propyl-1H-pyrazole-3-carboxamide | Intermediate in the preparation of Iso Viagra and pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction. Group: Biochemicals. Grades: Highly Purified. CAS No. 247583-78-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 7-Despropyl 7-Methyl Vardenafil | An impurity of Vardenafil. Vardenafil is a PDE5 inhibitor used for the treatment of erectile dysfunction. Synonyms: Vardenafil Impurity 3; 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5,7-dimethylimidazo[5,1-f][1,2,4]triazin-4(3H)-one. Molecular formula: C21H28N6O4S. Mole weight: 460.56. | |
| A350619 Hydrochloride | A350619 Hydrochloride is an activator of guanylyl cyclase (sGC). It activates basal sGC and synergistically activates sGC in the presence of NO. Acting as an sGC stimulator, it may be more effective than PDE5 inhibitors in the treatment of ED. Group: Biochemicals. Grades: Highly Purified. CAS No. 1217201-17-6. Pack Sizes: 5mg, 10mg. Molecular Formula: C21H26Cl2N2OS, Molecular Weight: 425.41. US Biological Life Sciences. | Worldwide |
| Acetildenafil | Acetildenafil is a Sildenafil (HY-15025) analogue, a phosphodiesterase 5 (PDE5) inhibitor. Acetildenafil can be isolated from herbal products [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 831217-01-7. Pack Sizes: 1 mg. Product ID: HY-13927. |  |
| Acetyl Vardenafil | Acetyl Vardenafil is an analogue of Vardenafil. Vardenafil is a phosphodiesterase type 5 (PDE5) inhibitor used for the treatment of erectile dysfunction. Synonyms: 2-[2-Ethoxy-5-[2-(4-ethyl-1-piperazinyl)acetyl]phenyl]-5-methyl-7-propyl-imidazo[5,1-f][1,2,4]triazin-4(1H)-one. CAS No. 1261351-28-3. Molecular formula: C25H34N6O3. Mole weight: 466.59. | |
| AP5U | AP5U, a potent and selective inhibitor of phosphodiesterase-5 (PDE5), has emerged as a viable therapeutic intervention for erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). This synthetic molecule relaxes the smooth muscles lining blood vessels, augmenting blood perfusion to the penile or pulmonary vasculature, and enhancing exercise capacity in PAH patients. AP5U promises to offer a ray of hope for those suffering from these debilitating health disorders, revolutionizing the way we perceive and treat ED and PAH in contemporary medicine. Synonyms: P1-(5'-Adenosyl) P5-(5'-uridyl) pentaphosphate, Sodium salt. Grade: ≥ 95% by HPLC. CAS No. 56983-25-6. Molecular formula: C19H28N7O24P5 (free acid). Mole weight: 893.33 (free acid). | |
| Avanafil | A phosphodiesterase (PDE5) inhibitor, used to treat erectile dysfunction. Synonyms: TA-1790; TA 1790; TA1790; Avanafil; trade name: Stendra; Spedra. Grade: 99%. CAS No. 330784-47-9. Molecular formula: C23H26ClN7O3. Mole weight: 483.95064. | |
| Avanafil metabolite M4 | Avanafil metabolite M4 is a major active metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil. Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanafil metabolite M4 and avanafil metabolite M16, as well as minor metabolites. Avanafil metabolite M4 inhibits PDE5 with 18% of the potency of avanafil. Grade: ≥98%. Molecular formula: C23H26ClN7O4. Mole weight: 499.95. | |
| Bay 60-7550 | Bay 60-7550 is a potent PDE2 inhibitor. It is 50-fold more selective for PDE2 compared to PDE1 and greater than 100-fold selective compared to PDE5 PDE3B, PDE4B, PDE7B, PDE8A, PDE9A, PDE10A, and PDE11A. Synonyms: BAY60-7550; BAY 60-7550; BAY-60-7550; BAY-607550; BAY 607550; BAY607550. Grade: >98%. CAS No. 439083-90-6. Molecular formula: C27H32N4O4. Mole weight: 476.57. | |
| Cilomilast | Cilomilast (SB-207499) is a potent, selective and orally active inhibitor of Phosphodiesterase 4 (PDE4) , with IC 50 s of ~100 and 120 nM for LPDE4 and HPDE4, respectively. Cilomilast shows selectivity for PDE4 over PDE1, PDE2, PDE3 and PDE5 ( IC 50=74, 65, >100, and 83 μM, respectively). Cilomilast has anti-inflammatory and immunomodulatory effects and can be used for thr research of asthma and chronic obstructive pulmonary disease (COPD) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-207499. CAS No. 153259-65-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10790. | |
| Desmethyl Thiosildenafil | Sildenafil thiono analog, a novel pyrazolopyrimidinethio nes as PDE5 inhibitor. Group: Biochemicals. Alternative Names: 5-[2-Ethoxy-5- (1-piperazinylsulfonyl) phenyl]-1, 6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4, 3-d]pyrimidine-7-thione. Grades: Highly Purified. CAS No. 479073-86-4. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| Desmethyl Thiosildenafil-d8 | Labeled Sildenafil thiono analog, a novel pyrazolopyrimidinethio nes as PDE5 inhibitor. Group: Biochemicals. Alternative Names: 5-[2-Ethoxy-5-(1-piperazinyl-d8-sulfonyl)phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidine-7-thione. Grades: Highly Purified. CAS No. 1215321-44-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Despropoxy Ethoxy Udenafil | An impurity of Udenafil. Udenafil is a PDE5 inhibitor used for the treatment of erectile dysfunction. Synonyms: Udenafil Impurity 2; 3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxy-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]-benzenesulfonamide; 3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxy-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]-benzenesulfonamide. CAS No. 268204-07-5. Molecular formula: C24H34N6O4S. Mole weight: 502.64. | |
| Gisadenafil | Gisadenafi is a potent PDE5 inhibitor (IC50 = 1.23 nM). Uses: A potent pde5 inhibitor. Synonyms: UK-369003; UK-369,003; 1-{6-ethoxy-5-[3-ethyl-6,7-dihydro-2-(2-methoxyethyl)-7-oxo-2H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-pyridylsulfonyl}-4-ethylpiperazine. Grade: ≥98%. CAS No. 334826-98-1. Molecular formula: C23H33N7O5S. Mole weight: 519.62. | |
| Gisadenafil besylate | Gisadenafil besylate is a potent PDE5 inhibitor (IC50 = 1.23 nM) with >100-fold selectivity for PDE5 over PDE6. Gisadenafil besylate inhibits the breakdown of cyclic phosphodiester secondary messenger molecules. Synonyms: UK 369003; UK369003; UK-369003; 5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one benzenesulfonate. Grade: ≥99% by HPLC. CAS No. 334827-98-4. Molecular formula: C23H33N7O5S.C6H6O3S. Mole weight: 677.79. | |
| Gisadenafil besylate | Gisadenafil besylate (UK 369003-26) is a specific, orally active phosphodiesterase 5 (PDE5) inhibitor with an IC 50 of 3.6 nM and prevents degradation of cyclic guanosine monophosphate (cGMP) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UK 369003-26. CAS No. 334827-98-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-108619. | |
| Hydroxythio Vardenafil | An impurity of Vardenafil. Vardenafil is a phosphodiesterase type 5 (PDE5) inhibitor used for the treatment of erectile dysfunction. Synonyms: 2-[2-Ethoxy-5-[[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl]phenyl]-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazine-4(1H)-thione; 4-[[3-(1,4-Dihydro-5-methyl-7-propyl-4-thioxoimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-1-piperazineethanol. CAS No. 912576-30-8. Molecular formula: C23H32N6O4S2. Mole weight: 520.68. | |
| Hydroxy Vardenafil | Hydroxy Vardenafil is a derivative of Vardenafil as a PDE5 inhibitor. Synonyms: 2-[2-Ethoxy-5-[[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl]phenyl]-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one; 4-[[3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo [5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-1-piperazineethanol. CAS No. 224785-98-2. Molecular formula: C23H32N6O5S. Mole weight: 504.61. | |
| IBMX | IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 ?M for PDE3, PDE4 and PDE5, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 3-Isobutyl-1-methylxanthine; Isobutylmethylxanthine. CAS No. 28822-58-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-12318. | |
| Icariin | Icariin is a flavonol glycoside and a PDE5 inhibitor (IC50 = 5.9 μM) with 67-fold selectivity for PDE5 over PDE4. It exhibits antioxidant and anticancer activity. At a concentration of 1 x 107 mol/L, Icariin induces differentiation of cardiomyocytes and upregulates the expression of cardiac genes. At 20 μg/ml, Icariin increases the proliferation and differentiation of cultured human osteoblasts. Icariin affects the aging mechanism from different aspects, can delay the aging process and prevent the occurrence of senile diseases. Uses: Ingredient of health care products. Synonyms: 3-[(6-Deoxy-a-L-mannopyranosyl)oxy]-7-b-D-glucopyranosyloxy-5-hydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one. Grade: ≥ 98%. CAS No. 489-32-7. Molecular formula: C33H40O15. Mole weight: 676.66. | |
| Icariin | Icariin is a flavonol glycoside. Icariin inhibits PDE5 and PDE4 activities with IC50s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-O-methyl-8-γ,γ-dimethylallylkaempferol-3-rhamnoside-7-glucoside. Product Category: Inhibitors. Appearance: Light-yellow powder. CAS No. 489-32-7. Molecular formula: C33H40O15. Mole weight: 676.66. Purity: 0.98. IUPACName: 5-Hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one. Canonical SMILES: C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2=C(OC3=C(C2=O)C(=CC(=C3CC=C(C)C)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)C5=CC=C(C=C5)OC)O)O)O. Density: 1.55 g/ml. Product ID: ACM489327. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Lodenafil | Lodenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Hydroxyhomosildenafil. CAS No. 139755-85-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123210. | |
| Lodenafil carbonate | Lodenafil carbonate, a dimer that acts as a proagent delivering Lodenafil in vivo, is an orally active phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 398507-55-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-108045. | |
| Methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate | Methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate is an impurity of Tadalafil, which is a phosphodiesterase type 5 (PDE5) inhibitor, primarily used to treat erectile dysfunction (ED) and symptoms of benign prostatic hyperplasia (BPH). Synonyms: Tadalafil intermediate; 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-, methyl ester, hydrochloride (1:1), (1R,3R)-; 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-, methyl ester, monohydrochloride, (1R,3R)-; 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-, methyl ester, monohydrochloride, (1R-cis)-; Methyl (1R,3R)-1-(2H-1,3-benzodioxol-5-yl)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carboxylate hydrochloride; (1R,3R)-1,2,3,4-Tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-Pyrido[3,4-B]indole-3-carboxylic acid methyl ester HCl; (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride. Grade: 98%. CAS No. 171752-68-4. Molecular formula: C20H19ClN2O4. Mole weight: 386.83. | |
| Mirodenafil | Mirodenafil (SK3530) is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil is a glucocorticoid receptor (GR) modulator Mirodenafil activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil can be used for the research of erectile dysfunction (ED), Alzheimers disease (AD) and systemic sclerosis (SSc) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SK3530. CAS No. 862189-95-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14930. | |
| Mirodenafil-[d7] Dihydrochloride | Mirodenafil-[d7] Dihydrochloride is the labelled Mirodenafil. Mirodenafil is a newly developed pyrrolopyrimidinone compound, which is a potent, reversible, and selective oral PDE5 inhibitor. Synonyms: Mirodenafil-d7 Dihydrochloride; 5-Ethyl-3,5-dihydro-2-[5-[[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl]-2-(propoxy-d7)phenyl]-7-propyl-4H-pyrrolo[3,2-d]pyrimidin-4-one Hydrochloride; 4-[[3-(5-Ethyl-4,5-dihydro-4-oxo-7-propyl-1H-pyrrolo[3,2-d]pyrimidin-2-yl)-4-(propoxy-d7)phenyl]sulfonyl]-1-piperazineethanol Dihydrochloride. Grade: 95% by HPLC; 95% atom D. CAS No. 1329651-11-7. Molecular formula: C26H32D7Cl2N5O5S. Mole weight: 611.63. | |
| Mirodenafil dihydrochloride | Mirodenafil (SK3530) dihydrochloride is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil dihydrochloride is a glucocorticoid receptor (GR) modulator Mirodenafil dihydrochloride activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil dihydrochloride can be used for the research of erectile dysfunction (ED), Alzheimers disease (AD) and systemic sclerosis (SSc) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SK-3530 dihydrochloride. CAS No. 862189-96-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14930A. | |
| Moracin M | Moracin M is a phenolic component that can be isolated from Mori Cortex , is a potent phosphodiesterase-4 (PDE4) inhibitor with IC 50 values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 56317-21-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-122942. | |
| N-Desethyl Vardenafil-[d8] | N-Desethyl Vardenafil-[d8] is the labelled analogue of N-Desethyl Vardenafil, which is a metabolite of Vardenafil. Vardenafil is a phosphodiesterase type 5 (PDE5) inhibitor used for the treatment of erectile dysfunction. Synonyms: N-Desethyl Vardenafil D8; 1-[[3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-piperazine-d8. Grade: 97%; ≥98% atom D. CAS No. 1184985-26-9. Molecular formula: C21H20D8N6O4S. Mole weight: 468.60. | |
| N-Desmethyl Sildenafil | N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Desmethylsildenafil; UK-103,320. CAS No. 139755-82-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117605. | |
| Osoresnontrine | Osoresnontrine (BI-409306) is a potent and selective PDE9A inhibitor, with an IC 50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A ( IC 50 , 1.4 μM), PDE1C ( IC 50 , 1.0 μM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A ( IC 50 all > 10 μM); Osoresnontrine can be used in the research of memory enhancement in CNS disorders. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BI-409306. CAS No. 1189767-28-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-112831. | |
| PDE5A1 active from Mouse, Recombinant | Mouse PDE5A (GenBank Accession No. NM_153422) full length with N-terminal GST-tag, MW=124 kDa, expressed in a Baculovirus infected Sf9 cell expression system. Mouse pde5a (genbank accession no. nm_153422) full length with n-terminal gst-tag, mw=124 kda, expressed in a baculovirus infected sf9 cell expression system. Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Group: Enzymes. Synonyms: CN5N; phosphodiesterase 5A, cGMP-specific; PDE5A1; PDE5A. Purity: > 70% (SDS-PAGE). Phosphodiesterase. Mole weight: mol wt 124 kDa. Storage: -70°C. Form: aqueous solution. Source: Baculovirus infected Sf9 cells. Species: Mouse. CN5N; phosphodiesterase 5A, cGMP-specific; PDE5A1; PDE5A. Cat No: NATE-0528. |  |
| Phosphodiesterase 5A1 from Human, Recombinant | PDE5 regulates vascular smooth muscle contraction and is involved in NO-cGMP signaling in platelets to control aggregation. PDE5 may also be involved in the regulation of cGMP signaling in the brain and may modulate pressure-induced cardiac hypertrophy and fibrosis. N-terminal gst-tagged 126 kda full-length protein. Applications: Phosphodiesterase (pde) is an enzyme that is used to breaks phosphodiester bonds. pde5 is a molecular target for the treatment of erectile dysfunction and pulmonary hypertension. pde5 is used to find novel pde5 inhibitors. Group: Enzymes. Synonyms: CN5N; phosphodiesterase 5A, cGMP-specific; PDE5A1; PDE5A; 3',5'-cyclic-GMP phosphodiesterase, PDE 5A1. Phosphodiesterase. Mole weight: 126 kDa. Storage: -70°C. Form: Supplied as a solution in 20% glycerol containing 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% TWEEN 20 and 3 mM DTT. Source: Sf9 cells. Species: Human. CN5N; phosphodiesterase 5A, cGMP-specific; PDE5A1; PDE5A; 3',5'-cyclic-GMP phosphodiesterase, PDE 5A1. Cat No: NATE-0527. | |
| Roflumilast | Roflumilast (APTA-2217) is a selective PDE4 inhibitor with IC 50 s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1 , PDEA4 , PDEB1 , and PDEB2 , respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells. Uses: Scientific research. Group: Signaling pathways. Alternative Names: APTA-2217; BYK 20869; B9302-107. CAS No. 162401-32-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15455. | |
| Roflumilast-d3 | Roflumilast-d3 is deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-(Cyclopropylmethoxy-d3)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide; B 9302-107-d3; BY 217-d3; BYK 20869-d3. Product Category: Inhibitors. Appearance: Crystallin Solid. CAS No. 1189992-00-4. Molecular formula: C17H11D3Cl2F2N2O3. Mole weight: 406.23. Canonical SMILES: [2H]C1(CC1)C([2H])([2H])OC2=C(C=CC(C(NC3=C(Cl)C=NC=C3Cl)=O)=C2)OC(F)F. Product ID: ACM1189992004. Alfa Chemistry ISO 9001:2015 Certified. | |
| Sildenafil | Sildenafil (UK-92480) is a potent phosphodiesterase type 5 ( PDE5 ) inhibitor with an IC 50 of 5.22 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UK-92480. CAS No. 139755-83-2. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg. Product ID: HY-15025. | |
| Sildenafil chlorosulfonyl | Sildenafil chlorosulfonyl is a synthetic intermediate in the synthesis of the phosphodiesterase 5 (PDE5) inhibitor Sildenafil (HY-15025). Uses: Scientific research. Group: Signaling pathways. CAS No. 139756-22-2. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W099761. | |
| Sildenafil citrate | Sildenafil citrate is a potent phosphodiesterase type 5 ( PDE5 ) inhibitor with IC 50 of 5.22 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UK-92480 citrate. CAS No. 171599-83-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-15025A. | |
| Tadalafil | Tadalafil (IC-351) is a PDE5 inhibitor with an IC 50 value of 1.8 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IC-351. CAS No. 171596-29-5. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-90009A. | |
| Tadalafil-[d3] | Tadalafil-[d3] is the labelled analogue of Tadalafil, which is an inhibitor of phosphodiesterase 5 and can be used to treat erectile dysfunction. Tadalafil is also a phosphodiesterase 5 (PDE5) inhibitor. Synonyms: Tadalafil D3. Grade: 95% by HPLC; 95% atom D. CAS No. 960226-55-5. Molecular formula: C22H16D3N3O4. Mole weight: 392.42. | |
| Thiosildenafil | An analog of Sildenafil; a novel pyrazolopyrimidinethio nes as PDE5 inhibitor. Group: Biochemicals. Alternative Names: 5-[2-Ethoxy-5-[ (4-methyl-1-piperazinyl) sulfonyl]phenyl]-1, 6-dihydro-1-methyl-3-propyl-. Grades: Highly Purified. CAS No. 479073-79-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Udenafil | Udenafil (DA8159) is a potent, selective and orally active phosphodiesterase type 5 (PDE5) inhibitor. Udenafil also inhibits cGMP hydrolysis and can be used for erectile dysfunction research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DA8159. CAS No. 268203-93-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18253. | |
| Udenafil-[d7] | Udenafil-[d7] is the labelled analogue of Udenafil. Udenafil is a PDE5 inhibitor used for the treatment of erectile dysfunction. Synonyms: Udenafil D7; 3-(1-Methyl-7-oxo-3-propyl-4,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[2-(1-methylpyrrolidin-2-yl)ethyl]-4-[(2H7)propyloxy]benzene-1-sulfonamide. Grade: 95% by HPLC; 98% atom D. CAS No. 1175992-76-3. Molecular formula: C25H29D7N6O4S. Mole weight: 523.7. | |
| Vardenafil | Vardenafil is a selective and orally active inhibitor of phosphodiesterase-5 ( PDE5 ), with an IC 50 of 0.7 nM. Vardenafil shows inhibitory towards PDE1, PDE6 with IC 50 s of 180 nM, and 11 nM, while IC 50 s are >1000 nM for PDE3 and PDE4 [1]. Vardenafil competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels [2]. Vardenafil can be used for the research of erectile dysfunction, hepatitis, diabetes [1]-[6]. Uses: Scientific research. Group: Natural products. CAS No. 224785-90-4. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-B0442. | |
| Vardenafil-[d4] | An isotope labelled form of Vardenafil. Vardenafil is a PDE5 inhibitor used for treating erectile dysfunction. Synonyms: 2-(2-ethoxy-5-{[4-ethyl(2,2,3,3-D4)piperazin-1-yl]sulfonyl}phenyl)-5-methyl-7-propyl-1H,4H-imidazo[4,3-f][1,2,4]triazin-4-one. Grade: 95% by HPLC; 98% atom D. CAS No. 2012598-83-1. Molecular formula: C23H28D4N6O4S. Mole weight: 492.63. | |
| Vardenafil-[d5] | Vardenafil-[d5] is the labelled analogue of Vardenafil. Vardenafil is a phosphodiesterase type 5 (PDE5) inhibitor used for the treatment of erectile dysfunction. Synonyms: Vardenafil-d5; 1-[[3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-(ethyl-d5)-piperazine. Grade: 95% by HPLC; 98% atom D. CAS No. 1189685-70-8. Molecular formula: C23H27D5N6O4S. Mole weight: 493.63. | |
| Vardenafil hydrochloride | Vardenafil hydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 ( PDE5 ), with an IC 50 of 0.7 nM. Vardenafil hydrochloride shows inhibitory towards PDE1, PDE6 with IC 50 s of 180 nM, and 11 nM, while IC 50 s are >1000 nM for PDE3 and PDE4 [1]. Vardenafil hydrochloride competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels [2]. Vardenafil hydrochloride can be used for the research of erectile dysfunction, hepatitis, diabetes [1]-[6]. Uses: Scientific research. Group: Natural products. CAS No. 224785-91-5. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-B0442A. | |
| Vardenafil Hydrochloride | Selective phosphodiesterase Type 5 (PDE5) inhibitor. Group: Biochemicals. Alternative Names: 1-[[3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-piperazine; Levitra; Nuviva. Grades: Highly Purified. CAS No. 224785-91-5. Pack Sizes: 1g, 2g, 5g. Molecular Formula: C??H??Cl?N?O?S, Molecular Weight: 561.52. US Biological Life Sciences. | Worldwide |
| Vardenafil hydrochloride trihydrate | Vardenafil hydrochloride trihydrate is a selective and orally active inhibitor of phosphodiesterase-5 ( PDE5 ), with an IC 50 of 0.7 nM. Vardenafil hydrochloride trihydrate shows inhibitory towards PDE1, PDE6 with IC 50 s of 180 nM, and 11 nM, while IC 50 s are >1000 nM for PDE3 and PDE4 [1]. Vardenafil hydrochloride trihydrate competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels [2]. Vardenafil hydrochloride trihydrate can be used for the research of erectile dysfunction, hepatitis, diabetes [1]-[6]. Uses: Scientific research. Group: Natural products. CAS No. 330808-88-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0442B. | |
| Zaprinast | Zaprinast (M&B 22948) is a selective inhibitor of cGMP-selective Phosphodiesterase (PDE5). Zaprinast causes a significant increase in cGMP levels in myocytes. Zaprinast is a G protein-coupled receptor 35 (GPR35) agonist which activates rat GPR35 strongly and activates human GPR35 moderately. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: M&B 22948. CAS No. 37762-06-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1816. | |
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